Supplementary Material: Nucleotide sequences of North Atlantic right whale DRB-like alleles (Accession Numbers: KF137593- KF137605). Alleles are aligned to the cow DRB3, cow DRB2, Human DRB1, Human DQB2, beluga DRB and beluga DQB alleles. The positions of the three primer sets used in this study are also indicated.

                 10        20        30        40        50        60        70             
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Cow-BoLA-DRB3         GATCCAACCACATTTCCTGGAGTATTATAAGGGCGAGTGTCATTTCTTCAACGGGACCGAGCGGGTGCGG 
Cow-BoLA-DQB1         ------------------.T.CC.G.T....T..CT....T.C...AC.........G............ 
Human-HLA-DRB1*1338   --------...G....T.......C.C..C.TCT.................T.....G............ 
Human-HLA-DQB1*03     --------AGG.....G..T.CC.G.T.....C.AT...CT.C...AC.........G.....C.....T 
Beluga-Dele-DRB*0102  --------------------------------------------------------------------.. 
Beluga-Dele-DQB*0202  ------------------------------------------------------C..G............ 
Eugl-DRB1*01          --------------------------------------------------------------------.. 
Eugl-DRB1*02          --------------------------------------------------------------------.. 
Eugl-DRB1*03          --------------------------------------------------------------------.. 
Eugl-DRB1*04          --------------------------------------------------------------------.. 
Eugl-DRB1*05          --------------------------------------------------------------------.. 
Eugl-DRB1*06          --------------------------------------------------------------------.. 
Eugl-DRB2*01          --------------------------------------------------------------------.. 
Eugl-DRB2*02          --------------------------------------------------------------------.. 
Eugl-DRB2*03          --------------------------------------------------------------------.. 
Eugl-DRB2*04          --------------------------------------------------------------------.. 
Eugl-DRB2*05          ------------------------------------------------------C..G............ 
Eugl-DRB*01           -------------------C.AC.G.T..............G.....CT..T.T...A...A.....G.. 
Eugl-DRB*02           -------------------C.AC.G.T..............G.....CT..T.T...A...A.....G.. 
Eugl-DRB*03           -------------------C.AC.G.T..............G.....CT..T.T...A...A.....G.. 
Eugl-DRB*04           -------------------C.AC.G.T..............G.....CT..T.T...A...A.....G.. 
DRB-5B/DRB-3B         CCC.AC.G...G....T..--------------------------------------------------- 
DRB-5C/DRB-3C         -----------------------------------------------....T.....G..........-- 
DQB2/DQB1             ---------------------------------.AT...CT.C...AC......---------------- 

                               80        90       100       110       120       130       140        
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Cow-BoLA-DRB3         TTCCTGGACAGACACTTCTATAATGGAGAAGAGTTCGTGC--GCTTCGACAGCGACTGGGGCGAGTTCCG 
Cow-BoLA-DQB1         .A.G..AC....T..A....C..CCAG..G....A.....--.G............GT........A... 
Human-HLA-DRB1*1338   ............T..........CCA...G....A.....--..............GT...G....A... 
Human-HLA-DQB1*03     .ATG..AC....T..A.......CC....G....A..CA.--..............GT..AG.T..A... 
Beluga-Dele-DRB*0102  C..G..AC.......A.......C..G..G..A...A...--...A..........GT........G... 
Beluga-Dele-DQB*0202  C..G..AC....T..A.......CC.G..G....A.....--..............GT........A... 
Eugl-DRB1*01          C.AG...T.......A.......CC.G..G....A.....--..............GT........A... 
Eugl-DRB1*02          .A.G..AG.......A.......CCAG..G......C...--.T............GT........A... 
Eugl-DRB1*03          .A.G..AC.......A.......CC.G..G......C...--.T............GT............ 
Eugl-DRB1*04          .A.G..AC.......A.......CC.G..G....A.....--..............GT............ 
Eugl-DRB1*05          .A.G..AC.......A.......CC.G..G....A.....--..............GT........A... 
Eugl-DRB1*06          C.AG...T.......A.......CC.G..G.......C..--..............GT............ 
Eugl-DRB2*01          C.AG..AC.......A.......CC.G..G...C......--..............GT........A... 
Eugl-DRB2*02          C.AG..AC.......A.......CC.G..G...C......--..............GT........A... 
Eugl-DRB2*03          GCAG..AC.......A.......CC.G..G...C......--..............GT........A... 
Eugl-DRB2*04          GCAG..AG....T..A.......CC.G..G....A..C..--..............GT........A... 
Eugl-DRB2*05          C.AG..AG...CT..A.......CC.G..G....A..C..--..............GT........A... 
Eugl-DRB*01           C.AG...T.......A.......CC.G..G....A..C..GC..............GT........A... 
Eugl-DRB*02           C.AG...T.......A.......CC.G..G....A..C..GC..............GT...T....A... 
Eugl-DRB*03           C.AG...T.......G.......CC.G..G....A..C..GC..............GT........A... 
Eugl-DRB*04           C.AG...T.......A.......CC.G..G....A..C..AC..............GT........A... 
DRB-5B/DRB-3B         ---------------------------------------------------------------------- 
DRB-5C/DRB-3C         ---------------------------------------------------------------------- 
DQB2/DQB1             ---------------------------------------------------------------------- 

                              150       160       170       180       190       200       210      
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|....|
Cow-BoLA-DRB3         GGCGGTGACCGAGCTGGGGCGGCCGGCCGCCGAGCACTGGAACAGCCAGAAGGACTTCCTGGAGCAGAAG 
Cow-BoLA-DQB1         ..........CC.............C..........................................C. 
Human-HLA-DRB1*1338   .........G..............TAG.......T....................A.......AG.CG.. 
Human-HLA-DQB1*03     .........GCC........CC..T.A.......T...................AG........AG..CC 
Beluga-Dele-DRB*0102  ..................C....G.A........TC..T..........................G..GA 
Beluga-Dele-DQB*0202  ..................C....G.A........T....................A.........G..CA 
Eugl-DRB1*01          ..................C.......A....A..T....................CA...........GA 
Eugl-DRB1*02          ..................C.......A....A..T....................A........G..G.A 
Eugl-DRB1*03          ..................C......T.....A..T....................A............GA 
Eugl-DRB1*04          ..................C......T.....A..T....................A............GA 
Eugl-DRB1*05          ..................C.......A.......T....................A.........G...A 
Eugl-DRB1*06          ..................C......T.....A..T....................A.........G...A 
Eugl-DRB2*01          ........G.........C.......A.......T....................A............CA 
Eugl-DRB2*02          ........G.........C.......A.......T....................A............CA 
Eugl-DRB2*03          ........G.........C.......A.......T....................A............CA 
Eugl-DRB2*04          ........G.........C...............T....................A.........G.G.A 
Eugl-DRB2*05          ........G.........C...............T....................A.........G.G.A 
Eugl-DRB*01           ..................C......AT....A.......................CA...........GA 
Eugl-DRB*02           ..................C......AT....A.......................CA...........GA 
Eugl-DRB*03           ..................C......AT....A.......................CA...........GA 
Eugl-DRB*04           ..................C......AT....A.......................CA...........GA 
DRB-5B/DRB-3B         ---------------------------------------------------------------------- 
DRB-5C/DRB-3C         ---------------------------------------------------------------------- 
DQB2/DQB1             ---------------------------------------------------------------------- 

                              220       230       240       250       260       270           
                      ....|....|....|....|....|....|....|....|....|....|....|....|....|...
Cow-BoLA-DRB3         CGGGCCGAGGTGGACAGGGTGTGCAGACACAACTACGGGGGTGTGGAGAGTTTCACTGTGCAGCGGCG 
Cow-BoLA-DQB1         .................C..................CAACTG.A.CTC.TCACA-------------- 
Human-HLA-DRB1*1338   .......C........CCTAC...................T..GT.....C.....G........... 
Human-HLA-DQB1*03     .....G...T......C...................CA.TTG.A.CTCC.CACG..CT.......... 
Beluga-Dele-DRB*0102  ................C.......................T..G.....------------------- 
Beluga-Dele-DQB*0202  .........C......C.-------------------------------------------------- 
Eugl-DRB1*01          .........C......C.......................T....----------------------- 
Eugl-DRB1*02          ......TC........C.TAC...................T..GT----------------------- 
Eugl-DRB1*03          ........AC......C.......................T....----------------------- 
Eugl-DRB1*04          ........AC......C.......................T....----------------------- 
Eugl-DRB1*05          .......T........C.......................T..GT----------------------- 
Eugl-DRB1*06          .........C......C.......................T....----------------------- 
Eugl-DRB2*01          .........C......C...................A...T..AT----------------------- 
Eugl-DRB2*02          .........C......C...................A...T..A.----------------------- 
Eugl-DRB2*03          .........C......C...................A...T..A.----------------------- 
Eugl-DRB2*04          .......C........C...................A...T..AT----------------------- 
Eugl-DRB2*05          .......C........C.-------------------------------------------------- 
Eugl-DRB*01           .......C........C.......................T........------------------- 
Eugl-DRB*02           .......C........C.......................T........------------------- 
Eugl-DRB*03           .......C........C.......................T........                    
Eugl-DRB*04           .......C........C.......................T........------------------- 
DRB-5B/DRB-3B         -------------------------------------------------................... 
DRB-5C/DRB-3C         ---------------------------------------------...........A.A.A...---- 
DQB2/DQB1             ------------------..................CA.-----------------------------