chain,site,reference,substitution,conservative,in_pdb,layer,date,location,gisaid_count,usv_count,ddG,single,multiple,associates,strains A,1909,E,G,False,True,SURFACE,2020-04-12,England,5,1,2.22135847,True,False,,hCoV-19/England/CAMB-8174E/2020 A,1910,Q,K,False,True,SURFACE,2020-05-14,Romania,1,1,1.370863372,True,False,,hCoV-19/Romania/284468/2020 A,1911,P,L,False,True,BOUNDARY,2020-03-27,Scotland,1,1,0.124442768,True,False,,hCoV-19/Scotland/CVR780/2020 A,1916,P,S,False,True,SURFACE,2020-04-11,USA,2,1,3.175504039,True,False,,hCoV-19/USA/CA-CZB-1456/2020 A,1917,N,H,False,True,BOUNDARY,2020-04-16,Wales,1,1,3.01239259,True,False,,hCoV-19/Wales/PHWC-3416A/2020 A,1917,N,K,False,True,BOUNDARY,2020-03-01,France,2,1,5.279701884,True,False,,hCoV-19/France/10069NM/2020 A,1921,P,L,False,True,SURFACE,2020-01-01,England,41,1,3.689775086,True,False,,hCoV-19/England/OXON-AE2B3/2020 A,1921,P,Q,False,True,SURFACE,2020-03-23,USA,3,1,2.600154598,True,False,,hCoV-19/USA/NM-UNM-00064/2020 A,1921,P,S,False,True,SURFACE,2020-01-01,England,65,2,2.383183728,True,True,A_S2024L,hCoV-19/England/OXON-AD779/2020;hCoV-19/New_Zealand/20VR0990/2020 A,1922,N,S,True,True,SURFACE,2020-03-02,England,2,1,1.900357852,True,False,,hCoV-19/England/20108003202/2020 A,1923,A,S,False,True,BOUNDARY,2020-04-28,England,1,1,2.718031367,True,False,,hCoV-19/England/PORT-2CF3F3/2020 A,1923,A,T,False,True,BOUNDARY,2020-03-25,USA,1,1,1.808887005,True,False,,hCoV-19/USA/CA-CZB030/2020 A,1923,A,V,True,True,BOUNDARY,2020-04-12,England,2,1,0.215526735,True,False,,hCoV-19/England/SHEF-C4E77/2020 A,1924,S,G,False,True,BOUNDARY,2020-03-05,USA,2,1,2.359688143,True,False,,hCoV-19/USA/MN_0100/2020 A,1924,S,I,False,True,BOUNDARY,2020-04-25,Netherlands,1,1,-2.92581926,True,False,,hCoV-19/Netherlands/ZuidHolland_184/2020 A,1924,S,N,True,True,BOUNDARY,2020-03-24,USA,1,1,2.268909661,True,False,,hCoV-19/USA/WA-S562/2020 A,1929,K,T,False,True,SURFACE,2020-03-14,USA,4,1,0.31251159300000003,True,False,,hCoV-19/USA/MN62-MDH62/2020 A,1931,V,I,True,True,SURFACE,2020-04-25,Brazil,1,1,-0.7369637720000001,True,False,,hCoV-19/Brazil/RJ-2733/2020 A,1935,I,T,False,True,SURFACE,2020-03-22,USA,3,1,1.1160268009999998,True,False,,hCoV-19/USA/MA-MGH-00570/2020 A,1935,I,V,True,True,SURFACE,2020-04-10,Wales,1,1,1.421034464,True,False,,hCoV-19/Wales/PHWC-30BF7/2020 A,1938,A,V,True,True,BOUNDARY,2020-03-09,Lebanon,1,1,6.621943976,True,False,,hCoV-19/Lebanon/S11_765/2020 A,1939,D,G,False,True,SURFACE,2020-03-23,France,10,2,0.019024856,True,True,A_T2016K,hCoV-19/France/HF3677/2020;hCoV-19/India/CCMB_J045/2020 A,1939,D,N,False,True,SURFACE,2020-03-20,Wales,3,1,-1.5566212659999998,True,False,,hCoV-19/Wales/PHWC-24BE7/2020 A,1939,D,Y,False,True,SURFACE,2020-03-21,England,1,1,-3.911240394,True,False,,hCoV-19/England/SHEF-C07F8/2020 A,1943,Q,K,False,True,SURFACE,2020-04-22,Scotland,1,1,-0.8728169179999999,True,False,,hCoV-19/Scotland/CVR2921/2020 A,1943,Q,R,False,True,SURFACE,2020-03-28,Scotland,1,1,-2.114325586,True,False,,hCoV-19/Scotland/CVR883/2020 A,1944,L,S,False,True,BOUNDARY,2020-03-28,Denmark,1,1,6.024065596,True,False,,hCoV-19/Denmark/ALAB-SSI-650/2020 A,1945,T,I,False,True,BOUNDARY,2020-03-19,Spain,1,1,-2.3972586380000003,True,False,,hCoV-19/Spain/COV001459/2020 A,1945,T,N,True,True,BOUNDARY,2020-04-28,England,1,1,-1.963685016,True,False,,hCoV-19/England/NORW-E8E40/2020 A,1946,G,S,False,True,SURFACE,2020-03-12,England,3,1,-1.128857298,True,False,,hCoV-19/England/CAMB-84C00/2020 A,1950,P,H,False,True,SURFACE,2020-03-24,England,1,1,4.450072083999999,True,False,,hCoV-19/England/SHEF-C4C13/2020 A,1950,P,L,False,True,SURFACE,2020-04-15,Northern_Ireland,1,1,3.156037978,True,False,,hCoV-19/Northern_Ireland/NIRE-FAC7E/2020 A,1950,P,S,False,True,SURFACE,2020-05-14,England,1,1,2.774184982,True,False,,hCoV-19/England/CAMB-1B286E/2020 A,1952,S,L,False,True,SURFACE,2020-03-17,Netherlands,5,1,-1.976580951,True,False,,hCoV-19/Netherlands/ZuidHolland_37/2020 A,1953,R,K,True,True,SURFACE,2020-03-26,England,14,1,-0.53476704,True,False,,hCoV-19/England/LIVE-9B34D/2020 A,1955,L,F,True,True,SURFACE,2020-03-16,USA,1,1,1.794034683,True,False,,hCoV-19/USA/NY-WCMP12F03P/2020 A,1955,L,I,True,True,SURFACE,2020-04-07,Switzerland,1,1,3.763470114,True,False,,hCoV-19/Switzerland/110508/2020 A,1958,T,A,False,True,BOUNDARY,2020-04-12,USA,1,1,3.673781866,True,False,,hCoV-19/USA/UT-01841/2020 A,1962,D,E,True,True,SURFACE,2020-04-28,Netherlands,2,1,4.768542647,True,False,,hCoV-19/Netherlands/ZuidHolland_152/2020 A,1962,D,Y,False,True,SURFACE,2020-03-22,England,1,1,3.486346976,True,False,,hCoV-19/England/CAMB-7324E/2020 A,1966,D,E,True,True,BOUNDARY,2020-03-11,Netherlands,2,1,3.923790957,True,False,,hCoV-19/Netherlands/NoordBrabant_60/2020 A,1968,V,L,True,True,BOUNDARY,2020-03-17,SouthAfrica,1,1,3.259057194,True,False,,hCoV-19/SouthAfrica/Tygerberg_01/2020 A,1970,I,V,True,True,BOUNDARY,2020-04-05,England,1,1,1.789869656,True,False,,hCoV-19/England/CAMB-7D5B4/2020 A,1973,K,R,True,True,SURFACE,2020-04-26,India,1,1,-1.310770135,True,False,,hCoV-19/India/GBRC23/2020 A,1976,T,I,False,True,SURFACE,2020-02-07,Beijing,1,1,2.136849221,True,False,,hCoV-19/Beijing/BJ709/2020 A,1977,P,L,False,True,SURFACE,2020-03-18,France,3,1,7.740941292,True,False,,hCoV-19/France/B5325/2020 A,1978,S,F,False,True,SURFACE,2020-03-26,USA,6,1,5.112350118,True,False,,hCoV-19/USA/NY-NYUMC793/2020 A,1978,S,P,False,True,SURFACE,2020-04-10,India,1,1,,False,True,A_T2016K,hCoV-19/India/CCMB_K128/2020 A,1978,S,Y,False,True,SURFACE,2020-03-13,Lebanon,1,1,0.301205072,True,False,,hCoV-19/Lebanon/S8_767/2020 A,1979,F,L,True,True,BOUNDARY,2020-03-25,Turkey,1,1,2.426941878,True,False,,hCoV-19/Turkey/HSGM-439/2020 A,1982,G,R,False,True,CORE,2020-04-07,USA,1,1,31.01579327,True,False,,hCoV-19/USA/CT-CDC-6001/2020 A,1983,A,V,True,True,BOUNDARY,2020-04-19,England,1,1,3.186079815,True,False,,hCoV-19/England/CAMB-1AAE0D/2020 A,1988,K,R,True,True,BOUNDARY,2020-02-01,Germany,6,1,2.1214056130000003,True,False,,hCoV-19/Germany/FFM4/2020 A,1991,V,F,True,True,BOUNDARY,2020-03-18,Taiwan,1,1,-1.683040562,True,False,,hCoV-19/Taiwan/TSGH-12/2020 A,1991,V,I,True,True,BOUNDARY,2020-04-18,England,1,1,5.039603854,True,False,,hCoV-19/England/LIVE-9A29C/2020 A,1995,N,D,False,True,SURFACE,2020-04-06,Russia,1,1,0.337893961,True,False,,hCoV-19/Russia/StPetersburg-RII4678S/2020 A,1995,N,H,False,True,SURFACE,2020-03-09,Spain,7,1,3.636848655,True,False,,hCoV-19/Spain/Madrid_H12_1502/2020 A,1996,N,S,True,True,SURFACE,2020-04-15,New_Zealand,1,1,3.076360947,True,False,,hCoV-19/New_Zealand/20VR2495/2020 A,1997,A,S,False,True,SURFACE,2020-05-11,USA,1,1,1.0093730159999998,True,False,,hCoV-19/USA/CA-CZB-1546/2020 A,1997,A,V,True,True,SURFACE,2020-01-01,Netherlands,32,1,-1.731429542,True,False,,hCoV-19/Netherlands/NoordBrabant_65/2020 A,1998,T,I,False,True,BOUNDARY,2020-03-20,USA,3,1,-5.037088081,True,False,,hCoV-19/USA/CA-CZB-1230/2020 A,2000,K,R,True,True,SURFACE,2020-04-15,Scotland,1,1,0.772879451,True,False,,hCoV-19/Scotland/CVR2515/2020 A,2001,A,T,False,True,SURFACE,2020-02-03,Shangrao,2,1,0.895407218,True,False,,hCoV-19/Shangrao/JX1177/2020 A,2001,A,V,True,True,SURFACE,2020-01-01,Netherlands,5,1,-0.060875419000000014,True,False,,hCoV-19/Netherlands/NoordBrabant_156/2020 A,2002,T,M,False,True,CORE,2020-03-30,England,5,2,-0.098954083,True,True,A_S2015R;A_T2016K,hCoV-19/England/CAMB-71DF4/2020;hCoV-19/India/ILSCV14374/2020 A,2003,Y,C,False,True,SURFACE,2020-03-30,USA,1,1,4.218760017,True,False,,hCoV-19/USA/NY-NYUMC499/2020 A,2003,Y,F,True,True,SURFACE,2020-04-11,Spain,1,1,-1.12201654,True,False,,hCoV-19/Spain/Donostia-San_Sebastian2117/2020 A,2004,K,R,True,True,SURFACE,2020-03-10,Vietnam,1,1,0.305891238,True,False,,hCoV-19/Vietnam/VNHN_0418/2020 A,2007,T,I,False,True,SURFACE,2020-03-14,USA,16,1,-2.1144661680000003,True,False,,hCoV-19/USA/WA-UW148/2020 A,2010,I,M,True,True,BOUNDARY,2020-04-06,Wales,4,1,-6.517249632,True,False,,hCoV-19/Wales/PHWC-2ED41/2020 A,2010,I,T,False,True,BOUNDARY,2020-01-01,England,2,1,2.71541843,True,False,,hCoV-19/England/OXON-AEC1F/2020 A,2014,W,R,False,True,BOUNDARY,2020-04-04,England,1,1,7.714291927,True,False,,hCoV-19/England/LOND-D3C20/2020 A,2015,S,G,False,True,SURFACE,2020-01-13,Shenzhen,11,1,2.170386596,True,False,,hCoV-19/Shenzhen/SZTH-001/2020 A,2015,S,K,False,True,SURFACE,2020-03-31,Singapore,2,1,,False,True,A_T2016K,hCoV-19/Singapore/40/2020 A,2015,S,R,False,True,SURFACE,2020-01-01,Singapore,200,4,-0.10666802,True,True,A_T2002M;A_T2016K;A_Q2034R,hCoV-19/England/BRIS-12317C/2020;hCoV-19/Singapore/361/2020;hCoV-19/Singapore/308/2020;hCoV-19/India/ILSCV14374/2020 A,2016,T,A,False,True,SURFACE,2020-04-12,England,2,1,-1.011249424,True,False,,hCoV-19/England/SHEF-CC088/2020 A,2016,T,I,False,True,SURFACE,2020-03-24,Belgium,6,1,-0.7435461729999999,True,False,,hCoV-19/Belgium/UGent-19/2020 A,2016,T,K,False,True,SURFACE,2020-01-01,Singapore,452,7,-2.293820622,True,True,A_D1939G;A_S1978P;A_T2002M;A_S2015K;A_S2015R;A_Q2034R,hCoV-19/USA/GA_2147/2020;hCoV-19/Singapore/361/2020;hCoV-19/Singapore/40/2020;hCoV-19/India/CCMB_J045/2020;hCoV-19/India/CCMB_K128/2020;hCoV-19/Singapore/308/2020;hCoV-19/India/ILSCV14374/2020 A,2016,T,R,False,True,SURFACE,2020-03-09,Greece,2,1,0.05740954700000001,True,False,,hCoV-19/Greece/133/2020 A,2018,P,L,False,True,SURFACE,2020-02-13,Sichuan,2,1,1.736375156,True,False,,hCoV-19/Sichuan/SC-PHCC2-042/2020 A,2018,P,Q,False,True,SURFACE,2020-04-19,Netherlands,1,1,4.534243695,True,False,,hCoV-19/Netherlands/Limburg_26/2020 A,2018,P,S,False,True,SURFACE,2020-03-05,USA,5,1,3.290658504,True,False,,hCoV-19/USA/WA-S114/2020 A,2018,P,T,False,True,SURFACE,2020-03-11,Chile,1,1,3.25564972,True,False,,hCoV-19/Chile/Santiago_18/2020 A,2019,V,F,True,True,SURFACE,2020-04-02,Spain,2,1,-3.571329006,True,False,,hCoV-19/Spain/COV003693/2020 A,2020,E,G,False,True,SURFACE,2020-03-16,USA,2,1,1.107591686,True,False,,hCoV-19/USA/NY-PV08412/2020 A,2021,T,I,False,True,SURFACE,2020-02-21,Korea,1,1,1.070903657,True,False,,hCoV-19/Korea/KCDC2048/2020 A,2022,S,L,False,False,,2020-03-22,England,2,1,,True,False,,hCoV-19/England/CAMB-72625/2020 A,2022,S,P,False,False,,2020-03-12,USA,3,1,,True,False,,hCoV-19/USA/NY-PV09423/2020 A,2024,S,L,False,False,,2020-03-17,New_Zealand,14,2,,True,True,A_P1921S,hCoV-19/Latvia/09/2020;hCoV-19/New_Zealand/20VR0990/2020 A,2026,D,G,False,False,,2020-05-13,Sweden,1,1,,True,False,,hCoV-19/Sweden/20-51391/2020 A,2026,D,N,False,False,,2020-03-25,USA,2,1,,True,False,,hCoV-19/USA/WI-UW-213/2020 A,2027,V,A,True,False,,2020-03-20,USA,1,1,,True,False,,hCoV-19/USA/WA-UW-1718/2020 A,2028,L,P,False,False,,2020-02-01,Yingtan,1,1,,True,False,,hCoV-19/Yingtan/JX2480/2020 A,2029,K,E,False,False,,2020-05-09,India,1,1,,True,False,,hCoV-19/India/GBRC94/2020 A,2029,K,N,False,False,,2020-03-26,Switzerland,9,1,,True,False,,hCoV-19/Switzerland/100821/2020 A,2030,S,L,False,False,,2020-01-01,England,17,1,,True,False,,hCoV-19/England/CAMB-83D77/2020 A,2030,S,P,False,False,,2020-03-11,Netherlands,3,1,,True,False,,hCoV-19/Netherlands/NoordBrabant_111/2020 A,2031,E,A,False,False,,2020-03-28,Scotland,1,1,,True,False,,hCoV-19/Scotland/CVR898/2020 A,2032,D,G,False,False,,2020-03-14,Northern_Ireland,1,1,,True,False,,hCoV-19/Northern_Ireland/NIRE-1021DD/2020 A,2032,D,N,False,False,,2020-04-10,Spain,13,1,,True,False,,hCoV-19/Spain/Donostia-San_Sebastian2077/2020 A,2033,A,T,False,False,,2020-03-15,USA,6,1,,True,False,,hCoV-19/USA/TX-HMH010/2020 A,2033,A,V,True,False,,2020-01-29,Shanghai,21,1,,True,False,,hCoV-19/Shanghai/SH0041/2020 A,2034,Q,L,False,False,,2020-04-02,England,3,1,,True,False,,hCoV-19/England/CAMB-73D4D/2020 A,2034,Q,R,False,False,,2020-03-26,Denmark,4,2,,True,True,A_S2015R;A_T2016K,hCoV-19/Denmark/ALAB-SSI523/2020;hCoV-19/Singapore/308/2020 A,2035,G,R,False,False,,2020-04-13,England,7,1,,True,False,,hCoV-19/England/CAMB-826F5/2020 A,2036,M,I,True,False,,2020-04-03,England,2,1,,True,False,,hCoV-19/England/CAMB-791F0/2020 A,2036,M,V,True,False,,2020-03-26,Scotland,8,1,,True,False,,hCoV-19/Scotland/GCVR-17124F/2020 A,2037,D,E,True,False,,2020-03-19,USA,1,1,,True,False,,hCoV-19/USA/CT-Yale-014/2020 A,2037,D,G,False,False,,2020-04-11,USA,1,1,,True,False,,hCoV-19/USA/CA-CZB-1353/2020 A,2039,L,F,True,False,,2020-04-05,Wales,15,1,,True,False,,hCoV-19/Wales/PHWC-2A49B/2020 A,2040,A,V,True,False,,2020-03-25,Chile,4,1,,True,False,,hCoV-19/Chile/Temuco_7/2020 A,2042,E,A,False,False,,2020-05-16,India,1,1,,True,False,,hCoV-19/India/ILSCV21602/2020 A,2043,D,N,False,False,,2020-01-01,England,1,1,,True,False,,hCoV-19/England/BIRM-5F61F/2020 A,2044,L,V,True,False,,2020-04-03,USA,3,1,,True,False,,hCoV-19/USA/NM-UNM-00140/2020 A,2045,K,Q,False,False,,2020-03-14,USA,3,1,,True,False,,hCoV-19/USA/CA-SR0117/2020 A,2046,P,A,False,False,,2020-04-16,Denmark,1,1,,True,False,,hCoV-19/Denmark/ALAB-HH-240/2020 A,2046,P,L,False,False,,2020-03-09,Sweden,23,1,,True,False,,hCoV-19/Sweden/20-08108/2020 A,2046,P,S,False,False,,2020-03-01,Estonia,6,1,,True,False,,hCoV-19/Estonia/ChVir4266/2020 A,2047,V,F,True,False,,2020-03-20,Morocco,8,1,,True,False,,hCoV-19/Morocco/6894/2020 A,2048,S,F,False,False,,2020-03-23,England,1,1,,True,False,,hCoV-19/England/OXON-AF294/2020 A,2048,S,P,False,False,,2020-03-24,USA,2,1,,True,False,,hCoV-19/USA/MI-MDHHS-SC20375/2020 A,2049,E,K,False,False,,2020-03-24,Australia,1,1,,True,False,,hCoV-19/Australia/VIC562/2020 A,2052,V,L,True,False,,2020-03-20,England,2,1,,True,False,,hCoV-19/England/20129167204/2020 A,2052,V,M,True,False,,2020-03-23,England,11,1,,True,False,,hCoV-19/England/CAMB-72BAE/2020 A,2053,E,D,True,False,,2020-03-14,USA,1,1,,True,False,,hCoV-19/USA/WA-UW277/2020 A,2053,E,G,False,False,,2020-04-07,Northern_Ireland,1,1,,True,False,,hCoV-19/Northern_Ireland/NIRE-FB8B5/2020 A,2053,E,K,False,False,,2020-03-29,England,2,1,,True,False,,hCoV-19/England/NORT-2892CB/2020 A,2054,N,D,False,False,,2020-05-17,England,1,1,,True,False,,hCoV-19/England/BRIS-12BA00/2020 A,2055,P,S,False,False,,2020-03-01,Netherlands,4,1,,True,False,,hCoV-19/Netherlands/Utrecht_1363564/2020 A,2056,T,A,False,False,,2020-03-30,England,5,1,,True,False,,hCoV-19/England/CAMB-76481/2020 A,2058,Q,H,False,False,,2020-04-02,England,1,1,,True,False,,hCoV-19/England/CAMB-79B3E/2020 A,2059,K,N,False,False,,2020-03-26,USA,2,1,,True,False,,hCoV-19/USA/PA-MGSC49-05/2020 A,2059,K,R,True,False,,2020-04-03,Scotland,1,1,,True,False,,hCoV-19/Scotland/CVR1519/2020 A,2060,D,G,False,False,,2020-03-16,Switzerland,1,1,,True,False,,hCoV-19/Switzerland/100133/2020 A,2060,D,N,False,False,,2020-03-18,USA,5,1,,True,False,,hCoV-19/USA/NY-NYUMC89/2020 A,2060,D,Y,False,False,,2020-04-27,Portugal,1,1,,True,False,,hCoV-19/Portugal/PT0562/2020 A,2061,V,F,True,False,,2020-04-07,England,4,1,,True,False,,hCoV-19/England/BRIS-1236B9/2020 A,2061,V,I,True,False,,2020-01-01,Germany,15,1,,True,False,,hCoV-19/Germany/BavPat6-ChVir1247/2020 A,2062,L,F,True,False,,2020-02-28,Spain,13,1,,True,False,,hCoV-19/Spain/Andalucia201257/2020 A,2063,E,D,True,False,,2020-04-01,USA,1,1,,True,False,,hCoV-19/USA/WI-UW-96/2020 A,2065,N,S,True,False,,2020-03-28,England,3,1,,True,False,,hCoV-19/England/CAMB-722D6/2020 A,2066,V,L,True,False,,2020-04-13,Scotland,5,1,,True,False,,hCoV-19/Scotland/EDB3520/2020 A,2067,K,R,True,False,,2020-03-31,USA,1,1,,True,False,,hCoV-19/USA/CA-CZB-1683/2020 A,2070,E,G,False,False,,2020-03-10,England,2,1,,True,False,,hCoV-19/England/20112112106/2020 A,2071,V,F,True,False,,2020-04-12,England,4,1,,True,False,,hCoV-19/England/CAMB-7B4F5/2020 A,2072,V,I,True,False,,2020-04-23,Northern_Ireland,1,1,,True,False,,hCoV-19/Northern_Ireland/NIRE-FF81B/2020 A,2074,D,G,False,False,,2020-05-04,England,1,1,,True,False,,hCoV-19/England/CAMB-1AEC2D/2020