CIN_PDO: modelling chromosomal instability (CIN) in patient-derived tumor organoid (PDO) data

The folder (CIN_PDO) contains the simulation program and scripts used for modelling chromosomal instability (CIN) observed in the patient-derived tumor organoid (PDO) data in paper:

Reconstructing single-cell karyotype alterations in colorectal cancer reveals punctuated and gradual diversification patterns. Yannik Bollen, Ellen Stelloo, Petra van Leenen, Myrna van den Bos, Bas Ponsioen, Bingxin Lu, et al. (2021), Nature Genetics, accepted.