STUDY TO DETERMINE THE INCIDENCE OF EARLY DETECTION OF DISSEMINATED INTRAVASCULAR COAGULATION IN NEONATES WITH SEPSIS

Background: Sepsis is an uncontrolled progressive Infectious process, suspected or proven, which by the production of pro and anti-inflammatory cytokines can lead to systemic inflammatory response syndrome (SIRS). The aim of this study was to identify frequency of early symptomatic DIC in neonates presenting with sepsis resulting in major neonatal morbidity and mortality.

Study Design: It was a cross-sectional study.

Place and Duration of Study: This study was conducted at the Pediatric department of Mayo Hospital, Lahore for the duration of six months, from January 2020 to July 2020.

Materials and Methods: A total of 200 patients were included in this study. Venous sample 3cc was collected to get CBC, CRP, blood culture and sensitivity, PT, APTT, FDP’s, CXR, urine R/E and culture and sensitivity, LP when required. All the data was analyzed using SPSS version 20. Data was stratified for gestational age, gender and duration of symptoms to control the effect modifiers. Post-stratification chi-square test was applied. P-value ≤ 0.05 was considered as significant.

Results: The mean gestational age of the patients was 38.76 ± 1.19 weeks. The mean duration of symptoms was found as 13.25 ± 3.29 days. There were 111 (55.5%) males and 89 (45.5%) females in our study.  DIC was found in 85 patients (42.5%) while not found in 115 patients (57.5%). DIC was also stratified according to gestational age, gender and duration of symptoms and was found significant for gestational age and duration of symptoms.

Conclusion: A high percentage of DIC (42.5%) was found in patients presenting with neonatal sepsis.

Key Words: DIC, Sepsis; Neonates; NICU.