{ "identifier": { "identifier": "https://doi.org/10.3389/fnins.2020.00198", "identifierSource": "DOI" }, "title": "Expression-based polygenic score from the amygdala 5HTT gene network", "creators": [ { "fullName":"Patricia Pelufo Silveira", "roles": [ { "value": "Principal Investigator" } ] } ], "description": "This pipeline intends to facilitate the calculation of biologically informed polygenic scores from collected genomic data. This template can be adapted to create other expression-based polygenic risk scores. Data is 1) step by step description and 2) a list of genes that compose the gene network", "version": "1.0", "licenses": [ { "name": "CC BY-NC-SA 4.0" } ], "keywords": [ { "value": "Expression based Polygenic Risk Score" }, { "value": "Amygdala" }, { "value": "Serotonin Transporter 5HTT" }, { "value": "co-expression" }, { "value": "early-life" }, { "value": "PRS" } ], "distributions": [ { "formats": [ "CSV" ], "size": 1.06, "unit": { "value": "MB" }, "access": { "landingPage": "Not defined yet", "authorizations": [ { "value": "public" } ] } } ], "types": [ { "information": { "value": "Genetics" } } ], "isAbout": [ { "identifier": { "identifier": "9606", "identifierSource":"https://www.ncbi.nlm.nih.gov/taxonomy/9606" }, "name":"Homo sapiens" } ], "primaryPublications": [ { "identifier": { "identifier": "https://doi.org/10.3389/fnins.2020.00198" }, "title": "Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes.", "authors": [ { "fullName": "R.M.S. de Lima" }, { "fullName": "B. Barth" }, { "fullName": "D. M. Arcego" }, { "fullName": "E. J. de Mendonça Filho" }, { "fullName": "A. Clappison" }, { "fullName": "S. Patel" }, { "fullName": "Z. Wang" }, { "fullName": "I. Pokhvisneva" }, { "fullName": "R. B. Sassi" }, { "fullName": "G. B. C. Hall" }, { "fullName": "M. S. Kobor" }, { "fullName": "K. J. O'Donnell" }, { "fullName": "A. P. S. d. V. Bittencourt" }, { "fullName": "M. J. Meaney" }, { "fullName": "C. Dalmaz" }, { "fullName": "P. P. Silveira" } ] } ], "acknowledges": [ { "name": "Grants", "funders": [ { "name": "National Research Council of Brazil (CNPq)" }, { "name": "Coordination of Improvement of Higher Level Personnel (CAPES)" }, { "name": "The JPB Foundation through a grant to The JPB Research Network on Toxic Stress: A Project of the Center on the Developing Child at Harvard University" } ] } ], "extraProperties": [ { "category": "files", "values": [ { "value": 2 } ] }, { "category": "subjects", "values": [ { "value": 0 } ] }, { "category": "CONP_status", "values": [ { "value": "Canadian" } ] }, { "category": "origin_institution", "values": [ { "value": "McGill University" } ] }, { "category": "origin_city", "values": [ { "value": "Montreal" } ] }, { "category": "origin_province", "values": [ { "value": "Quebec" } ] }, { "category": "origin_country", "values": [ { "value": "Canada" } ] }, { "category": "contact", "values": [ { "value": "patricia.silveira@mcgill.ca" } ] } ] }