padj Superpath_name Total_genes Matched_genes Matched_symbols Pathway_URL 2.18042E-10 Photodynamic Therapy-induced NF-kB Survival Signaling 48 10 "IL1A, CXCL2, ETS1, IL1B, CSF2, NFKB1, MMP9, TNF, VEGFA, PTGS2" http://pathcards.genecards.org/card/photodynamic_therapy-induced_nf-kb_survival_signaling 1.16872E-09 Folate Metabolism 120 13 "ALOX15B, LDLR, IL1B, MIR6886, NFKB1, TNF, TCN1, PLAT, SAA4, SELENOP, PTGS2, SERPINA3, SAA2" http://pathcards.genecards.org/card/folate_metabolism 5.79996E-09 TNF Signaling Pathway 112 12 "CXCL6, CXCL2, EDN1, IL1B, CSF2, NFKB1, MAP3K8, MMP9, TNF, TRAF3, PTGS2, SOCS3" http://pathcards.genecards.org/card/tnf_signaling_pathway 6.13182E-09 Cytokine Signaling in Immune System 760 29 "IL1A, IL32, ITGB3, IL36G, FOXO1, FGF1, CXCL2, IFNGR1, IL7R, DUSP10, BLNK, IL1B, FLNB, DUSP4, ANXA1, CSF2, CD86, NFKB1, MAP3K8, LTB, PDGFB, MMP9, TNFSF14, TNF, TRAF3, VEGFA, PTGS2, SOCS3, IL16" http://pathcards.genecards.org/card/cytokine_signaling_in_immune_system 7.49856E-09 ERK Signaling 1179 37 "BMP2, IL1A, CDC42EP2, ITGB3, COL8A1, FOXO1, FGF1, CXCL6, LAMB3, CXCL14, CXCL2, CXCL16, IL7R, ETS1, EPHA4, IL1B, FLNB, CSF2, CACNB4, NFKB1, MAP3K8, PDGFB, FOSL1, HDGF, TNFSF14, PPP1R15A, TNF, TCF4, SOX6, PRKACB, TNFRSF10A, TNC, VEGFA, TUBA4A, PTGS2, TUBB3, IL16" http://pathcards.genecards.org/card/erk_signaling 8.50744E-09 IL-17 Family Signaling Pathways 116 12 "CXCL6, CXCL2, IL1B, CSF2, NFKB1, FOSL1, MMP9, TNF, TRAF3, S100A7, S100A8, PTGS2" http://pathcards.genecards.org/card/il-17_family_signaling_pathways 3.34881E-08 Cytoskeleton Remodeling Neurofilaments 82 10 "KRT17, KRT4, DST, TUBA1A, TUBA1B, TUBA1C, TUBB, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/cytoskeleton_remodeling_neurofilaments 9.58162E-08 Developmental Biology 1078 33 "KRT24, ITGB3, IVL, KRT17, FOXO1, FGF1, KRT4, EPHA4, DUSP10, KRT15, DUSP4, KRT23, CSF2, CACNB4, NFKB1, PDGFB, MMP9, PBX1, MIR6510, TNF, SPRR2E, RND1, TCF4, PPARGC1A, PRKACB, SPRR2A, VAV3, SEMA7A, VEGFA, SPRR1A, KRT6B, SPRR2D, TGM1" http://pathcards.genecards.org/card/developmental_biology 2.45961E-07 Amoebiasis 102 10 "LAMB3, CXCL2, IL1B, CSF2, NFKB1, RAB7B, TNF, PRKACB, SERPINB13, SERPINB10" http://pathcards.genecards.org/card/amoebiasis 3.47263E-07 Innate Immune System 2124 49 "IL1A, IL32, ITGB3, IL36G, FOXO1, FGF1, ADAM8, CXCL2, IFNGR1, CTSH, IL7R, B4GALT1, DUSP10, BLNK, IL1B, FLNB, DUSP4, ANXA1, CSF2, METTL7A, CD86, NFKB1, MAP3K8, LTB, PDGFB, PGLYRP4, LRMP, MMP9, TNFSF14, TNF, TCN1, SERPINB1, TRAF3, S100A7, S100A8, PRKACB, SLPI, VAV3, S100P, TUBB, SERPINB10, VEGFA, S100A12, TUBB4B, VNN1, PTGS2, SERPINA3, SOCS3, IL16" http://pathcards.genecards.org/card/innate_immune_system 3.47981E-07 Regulation of CFTR Activity (norm and CF) 106 10 "ADRB2, FLNB, TUBA1A, TUBA1B, PRKACB, TUBA1C, TUBB, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/regulation_of_cftr_activity_(norm_and_cf) 5.01333E-07 Fluid Shear Stress and Atherosclerosis 139 11 "IL1A, ITGB3, EDN1, IL1B, NFKB1, PDGFB, MMP9, TNF, PLAT, THBD, VEGFA" http://pathcards.genecards.org/card/fluid_shear_stress_and_atherosclerosis 5.97686E-07 Lung Fibrosis 63 8 "FGF1, CXCL2, EDN1, IL1B, CSF2, PDGFB, MMP9, TNF" http://pathcards.genecards.org/card/lung_fibrosis 7.00382E-07 Gap Junction 88 9 "PDGFB, TUBA1A, TUBA1B, PRKACB, TUBA1C, TUBB, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/gap_junction 7.47456E-07 PEDF Induced Signaling 743 25 "BMP2, IL1A, IL32, IL36G, CXCL6, CXCL14, CXCL2, CXCL16, IFNGR1, IL7R, EPHA4, EDN1, IL1B, CSF2, CACNB4, NFKB1, LTB, TNFSF14, PPP1R15A, TNF, PPARGC1A, TNFRSF10A, PTGS2, SOCS3, IL16" http://pathcards.genecards.org/card/pedf_induced_signaling 8.8158E-07 Keratinization 214 13 "KRT24, IVL, KRT17, KRT4, KRT15, KRT23, MIR6510, SPRR2E, SPRR2A, SPRR1A, KRT6B, SPRR2D, TGM1" http://pathcards.genecards.org/card/keratinization 1.0545E-06 Spinal Cord Injury 120 10 "IL1A, CXCL2, EPHA4, IL1B, ANXA1, LTB, MMP9, TNF, PTPRZ1, PTGS2" http://pathcards.genecards.org/card/spinal_cord_injury 1.09903E-06 Rheumatoid Arthritis 93 9 "IL1A, CXCL6, CXCL2, IL1B, CSF2, CD86, LTB, TNF, VEGFA" http://pathcards.genecards.org/card/rheumatoid_arthritis 1.41804E-06 Interleukin-10 Signaling 49 7 "IL1A, CXCL2, IL1B, CSF2, CD86, TNF, PTGS2" http://pathcards.genecards.org/card/interleukin-10_signaling 1.97794E-06 AGE-RAGE Signaling Pathway in Diabetic Complications 100 9 "IL1A, FOXO1, F3, EDN1, IL1B, NFKB1, TNF, THBD, VEGFA" http://pathcards.genecards.org/card/age-rage_signaling_pathway_in_diabetic_complications 2.05127E-06 Akt Signaling 682 23 "BMP2, IL1A, ITGB3, FOXO1, FGF1, CXCL6, CXCL14, CXCL2, CXCL16, IL7R, EPHA4, IL1B, CSF2, NFKB1, MAP3K8, PDGFB, FOSL1, HDGF, TNFSF14, TNF, TNFRSF10A, VAV3, IL16" http://pathcards.genecards.org/card/akt_signaling 2.10145E-06 PAK Pathway 683 23 "BMP2, IL1A, FGF1, CXCL6, CXCL14, CXCL2, CXCL16, IL7R, IL1B, FLNB, CSF2, NFKB1, PDGFB, HDGF, TNFSF14, TNF, TCF4, PRKACB, TNFRSF10A, TUBA4A, PTPRZ1, TUBB3, IL16" http://pathcards.genecards.org/card/pak_pathway 2.32001E-06 NF-kappa B Signaling Pathway 102 9 "CXCL2, BLNK, IL1B, NFKB1, LTB, TNFSF14, TNF, TRAF3, PTGS2" http://pathcards.genecards.org/card/nf-kappa_b_signaling_pathway 2.50934E-06 IL-1 Family Signaling Pathways 103 9 "IL1A, IL36G, F3, EDN1, IL1B, NFKB1, FOSL1, TNF, PTGS2" http://pathcards.genecards.org/card/il-1_family_signaling_pathways 3.45082E-06 Salmonella Infection (KEGG) 80 8 "IL1A, CXCL2, IFNGR1, IL1B, FLNB, CSF2, NFKB1, RAB7B" http://pathcards.genecards.org/card/salmonella_infection_(kegg) 5.20942E-06 EphB-EphrinB Signaling 144 10 "ITGB3, EPHA4, TUBA1A, TUBA1B, TUBA1C, VAV3, TUBB, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/ephb-ephrinb_signaling 5.64288E-06 Interleukin-4 and 13 Signaling 114 9 "IL1A, FOXO1, IL1B, ANXA1, MMP9, TNF, VEGFA, PTGS2, SOCS3" http://pathcards.genecards.org/card/interleukin-4_and_13_signaling 6.18015E-06 Cooperation of Prefoldin and TriC/CCT in Actin and Tubulin Folding 40 6 "TUBA1A, TUBA1B, TUBA1C, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/cooperation_of_prefoldin_and_triccct__in_actin_and_tubulin_folding 6.22426E-06 Development Slit-Robo Signaling 147 10 "GJB2, EPHA4, TUBA1A, RND1, TUBA1B, TUBA1C, TUBB, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/development_slit-robo_signaling 1.40426E-05 Osteoclast Differentiation 128 9 "IL1A, ITGB3, IFNGR1, BLNK, IL1B, NFKB1, FOSL1, TNF, SOCS3" http://pathcards.genecards.org/card/osteoclast_differentiation 1.55412E-05 Microglia Activation During Neuroinflammation: Microglia Polarization 71 7 "ITGB3, IL1B, CSF2, CD86, MMP9, TNF, PTGS2" http://pathcards.genecards.org/card/microglia_activation_during_neuroinflammation_microglia_polarization 1.68788E-05 Pathogenic Escherichia Coli Infection 202 11 "IL1B, NFKB1, TNF, TUBA1A, TUBA1B, TUBA1C, TNFRSF10A, TUBB, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/pathogenic_escherichia_coli_infection 1.74994E-05 NF-KappaB Family Pathway 242 12 "BMP2, IL1A, FGF1, IL1B, NFKB1, LTB, PDGFB, HDGF, TNF, TRAF3, PRKACB, VAV3" http://pathcards.genecards.org/card/nf-kappab_family_pathway 1.85345E-05 Proteolysis Role of Parkin in The Ubiquitin-Proteasomal Pathway 73 7 "TUBA1A, TUBA1B, TUBA1C, TUBB, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/proteolysis_role_of_parkin_in_the_ubiquitin-proteasomal_pathway 1.93814E-05 Cytokines and Inflammatory Response 29 5 "IL1A, CXCL2, IL1B, CSF2, TNF" http://pathcards.genecards.org/card/cytokines_and_inflammatory_response 3.29727E-05 Apoptosis-related Network Due to Altered Notch3 in Ovarian Cancer 54 6 "IL7R, ETS1, NFKB1, TNF, VAV3, SOCS3" http://pathcards.genecards.org/card/apoptosis-related_network_due_to_altered_notch3_in_ovarian_cancer 3.79527E-05 TGF-Beta Pathway 653 20 "BMP2, IL1A, ITGB3, FGF1, IFNGR1, IL7R, EPHA4, DUSP10, IL1B, DUSP4, NFKB1, MAP3K8, PDGFB, HDGF, TNF, TCF4, TNFRSF10A, VEGFA, SOCS3, IL16" http://pathcards.genecards.org/card/tgf-beta_pathway 4.7073E-05 IL-10 Pathway 35 5 "IL1A, IL1B, NFKB1, TNF, SOCS3" http://pathcards.genecards.org/card/il-10_pathway 5.13871E-05 NOTCH1 Regulation of Human Endothelial Cell Calcification 18 4 "SOX6, PLAT, MIR6073, VEGFA" http://pathcards.genecards.org/card/notch1_regulation_of_human_endothelial_cell_calcification 5.27126E-05 Phagosome 152 9 "ITGB3, RAB7B, TUBA1A, TUBA1B, TUBA1C, TUBB, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/phagosome 6.10651E-05 Melatonin Metabolism and Effects 37 5 "FOXO1, EDN1, NFKB1, MIR146A, MIR3142HG" http://pathcards.genecards.org/card/melatonin_metabolism_and_effects 6.21099E-05 MAPK Signaling Pathway 321 13 "IL1A, FGF1, DUSP10, IL1B, FLNB, DUSP4, CACNB4, NFKB1, MAP3K8, PDGFB, TNF, PRKACB, VEGFA" http://pathcards.genecards.org/card/mapk_signaling_pathway 6.41034E-05 Angiogenesis (CST) 89 7 "ITGB3, FGF1, F3, ETS1, MMP9, TNC, PTGS2" http://pathcards.genecards.org/card/angiogenesis_(cst) 6.88819E-05 Interleukin-1 Processing 7 3 "IL1A, IL1B, NFKB1" http://pathcards.genecards.org/card/interleukin-1_processing 8.75459E-05 Response to Elevated Platelet Cytosolic Ca2+ 639 19 "ITGB3, F3, ENDOD1, CSF2, PCDH7, CD109, PDGFB, PLAT, PRKACB, THBD, TNFRSF10A, VAV3, SERPINA4, SELENOP, VEGFA, TUBA4A, SERPINA3, SERPINA5, SERPINB2" http://pathcards.genecards.org/card/response_to_elevated_platelet_cytosolic_ca2 8.97857E-05 Microglia Activation During Neuroinflammation: Overview 94 7 "IL1B, CSF2, MMP9, TNF, PLAT, TNC, PTPRZ1" http://pathcards.genecards.org/card/microglia_activation_during_neuroinflammation_overview 9.58101E-05 Cell Cycle_Spindle Assembly and Chromosome Separation 95 7 "TUBA1A, TUBA1B, TUBA1C, TUBB, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/cell_cycle_spindle_assembly_and_chromosome_separation 9.77429E-05 Colorectal Cancer Metastasis 165 9 "IFNGR1, NFKB1, MMP9, TNF, TCF4, PRKACB, VEGFA, PTGS2, WNT7A" http://pathcards.genecards.org/card/colorectal_cancer_metastasis 0.000108219 Apoptosis Modulation and Signaling 249 11 "CTSH, NFKB1, MAP3K8, TNFSF14, TNF, TUBA1A, TRAF3, TUBA1B, TUBA1C, TNFRSF10A, TUBA4A" http://pathcards.genecards.org/card/apoptosis_modulation_and_signaling 0.000147842 Toll Comparative Pathway 102 7 "IL1A, IFNGR1, IL1B, NFKB1, FOSL1, TNF, PTGS2" http://pathcards.genecards.org/card/toll_comparative_pathway 0.000151458 Transcription_Role of VDR in Regulation of Genes Involved in Osteoporosis 45 5 "IL1A, IL1B, FOSL1, TNF, PRKACB" http://pathcards.genecards.org/card/transcription_role_of_vdr_in_regulation_of_genes_involved_in_osteoporosis 0.000182768 Toxoplasmosis 141 8 "IL1A, LAMB3, LDLR, IFNGR1, IL1B, NFKB1, TNF, PTGS2" http://pathcards.genecards.org/card/toxoplasmosis 0.000190552 Human Cytomegalovirus Infection 360 13 "ITGB3, CXCL2, IFNGR1, IL1B, CSF2, CD86, NFKB1, PDGFB, TNF, TRAF3, PRKACB, VEGFA, PTGS2" http://pathcards.genecards.org/card/human_cytomegalovirus_infection 0.00019746 Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 107 7 "CXCL6, CXCL14, CXCL2, CXCL16, TNFSF14, TNF, TNFRSF10A" http://pathcards.genecards.org/card/chemokine_superfamily_pathway_humanmouse_ligand-receptor_interactions 0.000236323 Transcriptional Misregulation in Cancer 186 9 "FOXO1, MAF, CSF2, CD86, NFKB1, NFKBIZ, MMP9, PBX1, PLAT" http://pathcards.genecards.org/card/transcriptional_misregulation_in_cancer 0.000245479 Formation of Fibrin Clot (Clotting Cascade) 50 5 "F3, PLAT, THBD, SERPINA5, SERPINB2" http://pathcards.genecards.org/card/formation_of_fibrin_clot_(clotting_cascade) 0.000255411 TRAF Pathway 188 9 "IL1A, IL1B, NFKB1, LTB, TNFSF14, TNF, TRAF3, PRKACB, TNFRSF10A" http://pathcards.genecards.org/card/traf_pathway 0.000258852 "NAD Metabolism, Sirtuins and Aging" 11 3 "FOXO1, NFKB1, NAMPT" http://pathcards.genecards.org/card/nad_metabolism_sirtuins_and_aging 0.000274644 Pathways in Cancer 531 16 "BMP2, FOXO1, FGF1, LAMB3, IFNGR1, IL7R, ETS1, EDN1, NFKB1, PDGFB, MMP9, TRAF3, PRKACB, VEGFA, PTGS2, WNT7A" http://pathcards.genecards.org/card/pathways_in_cancer 0.000321285 Focal Adhesion 283 11 "ITGB3, LAMB3, ETS1, FLNB, MIR4260, PDGFB, TNC, VAV3, SELENOP, VEGFA, PTGS2" http://pathcards.genecards.org/card/focal_adhesion 0.000378385 Calcineurin-regulated NFAT-dependent Transcription in Lymphocytes 55 5 "MAF, CSF2, FOSL1, TNF, PTGS2" http://pathcards.genecards.org/card/calcineurin-regulated_nfat-dependent_transcription_in_lymphocytes 0.000457363 Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 162 8 "IL1A, IL1B, NFKB1, PBX1, TNF, PPARGC1A, PRKACB, VEGFA" http://pathcards.genecards.org/card/sudden_infant_death_syndrome_(sids)_susceptibility_pathways 0.000457363 Th17 Cell Differentiation 162 8 "IL1A, IFNGR1, MAF, IL1B, CD86, NFKB1, TNF, SOCS3" http://pathcards.genecards.org/card/th17_cell_differentiation 0.000479132 Degradation of The Extracellular Matrix 297 11 "BMP2, ITGB3, COL8A1, LAMB3, ADAM8, MIR4260, DST, PDGFB, NID1, MMP9, TNC" http://pathcards.genecards.org/card/degradation_of_the_extracellular_matrix 0.000515367 G-Beta Gamma Signaling 349 12 "BMP2, GJB2, IVL, CACNB4, NFKB1, MMP9, PRKACB, VEGFA, TUBA4A, PTGS2, WNT7A, TUBB3" http://pathcards.genecards.org/card/g-beta_gamma_signaling 0.00052007 Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Mediated LDL Receptor Degradation 3 2 "LDLR, MIR6886" http://pathcards.genecards.org/card/proprotein_convertase_subtilisinkexin_type_9_(pcsk9)_mediated_ldl_receptor_degradation 0.000571101 Osteopontin-mediated Events 34 4 "ITGB3, NFKB1, MMP9, VAV3" http://pathcards.genecards.org/card/osteopontin-mediated_events 0.000571101 Validated Transcriptional Targets of AP1 Family Members Fra1 and Fra2 34 4 "IVL, FOSL1, MMP9, THBD" http://pathcards.genecards.org/card/validated_transcriptional_targets_of_ap1_family_members_fra1_and_fra2 0.00057511 Relaxin Signaling Pathway 256 10 "KRT24, KRT17, EDN1, KRT15, KRT23, NFKB1, MMP9, PRKACB, VEGFA, SOCS3" http://pathcards.genecards.org/card/relaxin_signaling_pathway 0.000644698 Cytoskeletal Signaling 308 11 "KRT17, FEZ1, KRT4, FLNB, MTSS1, TUBA1A, TUBA1B, VAV3, TUBB, TUBB3, KRT6B" http://pathcards.genecards.org/card/cytoskeletal_signaling 0.000699172 4-1BB Pathway 173 8 "IL1A, IFNGR1, IL1B, NFKB1, MAP3K8, PDGFB, TNF, TRAF3" http://pathcards.genecards.org/card/4-1bb_pathway 0.000799228 Endochondral Ossification 65 5 "MMP9, SOX6, PLAT, MIR6073, VEGFA" http://pathcards.genecards.org/card/endochondral_ossification 0.000836001 Hematopoietic Cell Lineage 99 6 "IL1A, ITGB3, IL7R, IL1B, CSF2, TNF" http://pathcards.genecards.org/card/hematopoietic_cell_lineage 0.000925895 G-protein Signaling Ras Family GTPases in Kinase Cascades (scheme) 101 6 "LDLR, MIR6886, NFKB1, FOSL1, VEGFA, SOCS3" http://pathcards.genecards.org/card/g-protein_signaling_ras_family_gtpases_in_kinase_cascades_(scheme) 0.000999862 T Cell Receptor Signaling Pathway 183 8 "IL1A, IFNGR1, IL1B, CSF2, NFKB1, MAP3K8, TNF, VAV3" http://pathcards.genecards.org/card/t_cell_receptor_signaling_pathway 0.001041282 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 142 7 "FOXO1, IL7R, NFKB1, FOSL1, TNF, NAMPT, SOCS3" http://pathcards.genecards.org/card/common_cytokine_receptor_gamma-chain_family_signaling_pathways 0.001042204 NF-kappaB Signaling 327 11 "BLNK, IL1B, NFKB1, NFKBIZ, PBX1, TNF, PRDM1, TRAF3, VTCN1, PTGS2, SOCS3" http://pathcards.genecards.org/card/nf-kappab_signaling 0.001067752 IL-2 Pathway 328 11 "IL1A, FOXO1, IFNGR1, BLNK, IL1B, NFKB1, MAP3K8, TNF, PRKACB, VAV3, SOCS3" http://pathcards.genecards.org/card/il-2_pathway 0.001127857 Chaperonin-mediated Protein Folding 105 6 "TUBA1A, TUBA1B, TUBA1C, TUBA4A, TUBB4B, TUBB3" http://pathcards.genecards.org/card/chaperonin-mediated_protein_folding 0.00118325 Senescence and Autophagy in Cancer 106 6 "BMP2, IL1A, CXCL14, IL1B, PLAT, SERPINB2" http://pathcards.genecards.org/card/senescence_and_autophagy_in_cancer 0.00125125 SREBF and MiR33 in Cholesterol and Lipid Homeostasis 19 3 "LDLR, MIR6886, PPARGC1A" http://pathcards.genecards.org/card/srebf_and_mir33_in_cholesterol_and_lipid_homeostasis 0.00125125 Immune Response_Oncostatin M Signaling Via JAK-Stat in Human Cells 19 3 "VEGFA, SERPINA3, SOCS3" http://pathcards.genecards.org/card/immune_response_oncostatin_m_signaling_via_jak-stat_in_human_cells 0.001354081 "Vemurafenib Pathway, Pharmacodynamics" 43 4 "FGF1, ETS1, PDGFB, VEGFA" http://pathcards.genecards.org/card/vemurafenib_pathway_pharmacodynamics