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Published February 6, 2020 | Version v1
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Extensive Literature Search Protocol - 2019 QPS update

  • 1. European Food Safety Authority
  • 2. Aristotle University of Thessaloniki, Greece
  • 3. Spanish National Research Council (Agencia Estatal Consejo Superior de Investigaciones Científicas, CSIC), Spain
  • 4. Universidad de León, Spain
  • 5. Teagasc, Ireland
  • 6. Institute of Agriculture and Food Research and Technology (IRTA), Spain
  • 7. French Agency for Food, Environmental and Occupational Health & Safety (Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail, ANSES)
  • 8. Department for Environment, Food and Rural Affairs (Defra) − Animal and Plant Health Agency (APHA), the United Kingdom
  • 9. Alma Mater Studiorum – University of Bologna (Alma Mater Studiorum – Università di Bologna, UNIBO), Italy
  • 10. University of Veterinary Medicine Vienna (Veterinärmedizinische Universität Wien), Austria
  • 11. National Food Agency, Sweden
  • 12. Technical University of Denmark, National Food Institute, Denmark
  • 13. Faculdade de Farmacia da Universidade do Porto (FFUP), Portugal
  • 14. Veterinary Public Health Institute of Piedmont, Liguria and Aosta Valley (Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta, IZSPLVA), Italy
  • 15. Agricultural University of Athens
  • 16. Italian National Institute of Health (Istituto Superiore di Sanita, ISS), Italy
  • 17. Università Cattolica del Sacro Cuore, Italy
  • 18. Universidad Politecnica de Cartagena, Spain
  • 19. Spanish National Research Council (Agencia Estatal Consejo Superior de Investigaciones Científicas, CSIC)
  • 20. Universidad de Oviedo, Spain
  • 21. Swedish University of Agricultural Sciences
  • 22. Wageningen University, the Netherlands
  • 23. Insttitute for Agricultural and Fisheries Research, Ministry of the Flemish Community, Belgium


Protocol for Extensive literature search (ELS), relevance screening and article evaluation for the maintenance and update of list of QPS-recommended biological agents intetionally added to food an feed

An ELS of studies related to safety concerns for humans, animals, plants and/or the environment of
microorganisms recommended for the Qualified Presumption of Safety (QPS) 2019 list will be performed.
The process will be performed according to the following main steps:
 ELS for potentially relevant citations;
 Relevance screening to select the citations identified by the literature search, based on titles and
abstract and then full text;
 Evaluation of articles according to pre-specified categories of possible safety concerns;
 Discussion between experts to come to collective expert evaluation of the outcome, reflected in the
QPS Opinion and Panel Statements.
Considering the purpose of the QPS approach, a broad search will be performed.
The review questions will be broken down into key elements using the PECO conceptual model:
 Population of interest (P)
 Exposure of interest (E)
 Comparator (C)
 Outcomes of interest (O).




Appendix B_ELS protocol_2019 QPS update.pdf

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Is supplemented by
Journal article: 10.2903/j.efsa.2020.5965 (DOI)
Journal article: 10.2903/j.efsa.2020.5966 (DOI)