Berberina: MedlinePlus suplementos

T ¿Qué es?
P La berberina es una sustancia química que se encuentra en varias plantas incluyendo el bérbero Europeo, la vara de oro, el sello de oro, la uva de Oregon, el phellodendron y el árbol de cúrcuma.
P La gente toma berberina para la insuficiencia cardiaca.
P Algunas personas se aplican berberina directamente sobre la piel para tratar las quemaduras y a los ojos para tratar el tracoma, una infección bacteriana que frecuentemente causa ceguera.

T ¿Qué tan efectivo es?
P Natural Medicines Comprehensive Database (La Base Exhaustiva de Datos de Medicamentos Naturales) clasifica la eficacia, basada en evidencia científica, de acuerdo a la siguiente escala: Eficaz, Probablemente Eficaz, Posiblemente Eficaz, Posiblemente Ineficaz, Probablemente Ineficaz, Ineficaz, e Insuficiente Evidencia para Hacer una Determinación.
P La clasificación de la eficacia para este producto es la siguiente:
t Posiblemente eficaz para...
- Diabetes. La berberina parece reducir levemente los niveles de azúcar en la sangre en personas con diabetes. Además, cierta investigación preliminar sugiere que la ingesta de 500 mg de berberina 2 a 3 veces por día durante hasta 3 meses podría controlar los niveles de azúcar en la sangre como la metmorfina o la rosiglitazona.
- Colesterol alto. Existe cierta evidencia de que la berberina puede ayudar a disminuir los niveles de colesterol en personas con colesterol alto. La ingesta de 500 mg de berberina dos veces por día durante 3 meses parece reducir el colesterol de lipoproteína de baja densidad (LDL o malo) y los niveles de triglicéridos en personas con colesterol alto.
t Insuficiente evidencia para hacer una determinación para...
- Quemaduras. La investigación preliminar sugiere que la aplicación a las quemaduras de segundo grado de un ungüento que contiene berberina y beta-sitosterol parece funcionar tan bien como el tratamiento convencional con sulfadiazina de plata.
- Insuficiencia cardiaca congestiva (ICC). La investigación preliminar sugiere que la berberina puede reducir algunos de los síntomas y reducir la tasa de mortalidad en algunas personas con insuficiencia cardiaca congestiva.
- Diarrea. Cierta investigación sugiere que el sulfato de berberina puede disminuir la diarrea en personas con ciertas infecciones bacterianas. Además, el clorhidrato de berberina parece acelerar el tiempo de recuperación en personas con diarrea cuando se la agrega a ciertos tratamientos estándar. Sin embargo, la berberina no parece mejorar los efectos de la tetraciclina en el tratamiento de la diarrea relacionada con la infección de cólera.
- Glaucoma. Cierta investigación preliminar sugiere que el uso de gotas para los ojos que contienen berberina tetrahidrozolina durante 3 días no produce una reducción de la presión ocular mayor que las gotas que contienen solo tetrahidrozolina personas con glaucoma.
- Úlceras estomacales causada por la infección por Helicobacter pylori. La investigación sugiere que la ingesta de berberina 3 veces por día durante 6 semanas es más efectivo que el medicamento ranitidina para combatir la infección por Helicobacter pylori.
- Hepatitis. Cierta evidencia sugiere que la ingesta diaria de berberina durante 2 meses disminuye los niveles de azúcar en la sangre, los triglicéridos y los marcadores de daño hepático en personas con diabetes y hepatitis B y C.
- Enfermedad hepática. Cierta evidencia sugiere que la ingesta de berberina durante 12 meses disminuye los niveles de grasa en la sangre y los marcadores de daño hepático en personas con la enfermedad hepática y diabetes.
- Síntomas menopáusicos. La investigación preliminar sugiere que la ingesta de berberina y las isoflavonas de soja puede reducir los síntomas menopáusicos.
- Síndrome metabólico. La ingesta de un producto combinado (Armolipid Plus) que contiene berberina, policosanol y l arroz de levadura roja podría mejorar la presion arterial y el flujo sanguíneo en personas con síndrome metabólico.
- Obesidad. La investigación preliminar sugiere que la ingesta de berberina durante 12 semanas puede reducir el peso en personas obesas hasta aproximadamente 5 libras.
- Osteoporosis. La investigación preliminar sugiere que la ingesta de berberina junto con vitamina D3, vitamina K y un químico encontrado en el lúpulo durante 14 semanas puede disminuir la pérdida ósea en mujeres menopáusicas con osteoporosis.
- Trastorno ovárico conocido como síndrome de ovario poliquístico (SOP). La investigación preliminar sugiere que la berberina puede reducir los niveles de azúcar en la sangre, colesterol, triglicéridos, testosterona y la proporción cintura-cadera en mujeres con SOP.
- Lesiones causadas por la radiación. Cierta evidencia sugiere que la ingesta de berberina durante la radioterapia puede reducir la aparición y gravedad de ciertas lesiones causadas por la radiación en pacientes tratados por cáncer.
- Bajo recuento de plaquetas (trombocitopenia). Bajo recuento de plaquetas (trombocitopenia). Cierta evidencia sugiere que la ingesta de berberina durante 15 días, ya sea sola o con prednisolona, puede aumentar el número de plaquetas n la sangre en personas con bajo recuento de plaquetas.
- Tracoma. Hay cierta evidencia que indica que un colirio que contiene berberina podría ser útil para el tratamiento del tracoma, una causa común de ceguera en los países en desarrollo.
- Otras afecciones.
P Se necesitan más pruebas para evaluar la eficacia de la berberina para estos usos.

T ¿Cómo funciona?
P La berberina podría producir latidos del corazón más fuertes. También podría ser capaz de matar las bacterias.

T ¿Hay preocupación por la seguridad de su uso?
P La berberina ES POSIBLEMENTE SEGURA en la mayoría de los adultos cuando se usa a corto plazo ya sea por vía oral o se aplica sobre la piel.
t Advertencias y precauciones especiales:
P Niños: NO ES SEGURO dar berberina a los recién nacidos. Puede causar kernicterus, un tipo raro de daño cerebral que puede ocurrir en los recién nacidos que tienen ictericia severa. La ictericia es la coloración amarillenta de la piel producida por un exceso de bilirrubina en la sangre. La bilirrubina es una sustancia química que se produce cuando los glóbulos rojos viejos se descomponen. Normalmente es eliminada por el hígado. La berberina puede impedir que el hígado elimine la bilirrubina lo suficientemente rápido.
P Embarazo y lactancia: Si está embarazada NO ES SEGURO tomar berberina por vía oral. Los investigadores creen que la berberina puede atravesar la placenta y puede causar daño al feto. Kernicterus, un tipo de daño cerebral, se ha desarrollado en los recién nacidos expuestos a la berberina.
P NO ES SEGURO tampoco tomar berberina si está amamantando. La berberina se puede transferir al lactante por la leche materna y podría causar daño.
P Diabetes: La berberina puede disminuir los niveles de azúcar en la sangre. En teoría, la berberina podría disminuir demasiado los niveles de azúcar en la sangre en los diabéticos que controlan sus niveles de azúcar en la sangre con insulina u otros medicamentos. Usar con precaución en personas con diabetes.
P Niveles altos de bilirrubina en sangre en ninos. La bilirrubina es un químico que se produce por la ruptura de los glóbulos rojos viejos, que normalmente es eliminada por el hígado. La berberina podría evitar que el hígado elimine la bilirrubina rápidamente. Esto podría causar problemas cerebrales especialmente en bebés con altos niveles de bilirrubina en sangre; por lo tanto evitar su uso.
P Presión arterial baja. La berberina podría disminuir la presión arterial, por lo tanto usar con precaución en personas con presión arterial baja.

T ¿Existen interacciones con medicamentos?
P Serias
P No tome esta combinación
P Ciclosporina (Neoral, Sandimmune)
P El cuerpo descompone la ciclosporina (Neoral, Sandimmune) para deshacerse de ella. La berberina podría disminuir la rapidez con que el cuerpo descompone la ciclosporina (Neoral, Sandimmune). La ciclosporina (Neoral, Sandimmune) podría acumularse en el cuerpo y podría causar posibles efectos secundarios.
P Medicamentos para la diabetes (Antidepresivos)
P La berberina podría disminuir los niveles de azúcar en la sangre. Los medicamentos para la diabetes también se usan para disminuir los niveles de azúcar en la sangre. La ingesta de berberina junto con medicamentos para la diabetes podría causar una marcada disminución de los niveles de azúcar en la sangre. Controle minuciosamente sus niveles de azúcar en sangre. Podría necesitar modificar la dosis de su medicamento para la diabetes.
P Algunos medicamentos usados para la diabetes incluyen glimepirida (Amaryl), gliburida (Diabeta, Glynase, PresTab, Micronase), insulina, pioglitazona (Actos), rosiglitazona (Avandia) y otros.
P Moderadas
P Tenga cuidado con esta combinación
P Dextrometorfano (Robitussin DM y otros)
P El cuerpo descompone el dextrometorfano (Robitussin DM y otros) a fin de eliminarlo. La berberina podría disminuir la velocidad con la que hígado descompone el dextrometorfano (Robitussin DM y otros). La ingesta de berberina junto con dextrometorfano (Robitussin DM y otros) podría aumentar los efectos y los efectos secundarios del dextrometorfano (Robitussin DM y otros).
P Losartan (Cozaar)
P El hígado active el losartán (Cozaar) para hacerlo funcionar. La berberina podría disminuir la velocidad con la que hígado descompone el losartán (Cozaar). La ingesta de berberina junto con losartán (Cozaar) podría disminuir los efectos del losartán.
P Medicamentos modificados por el hígado (Citocromo P450 3A4 [CYP3A4] sustratos)
P Algunos medicamentos son modificados y descompuestos por el hígado. La berberina podría disminuir la rapidez con que el hígado descompone algunos medicamentos. El tomar berberina, junto con otros medicamentos que son metabolizados por el hígado puede aumentar los efectos y efectos secundarios de algunos medicamentos. Antes de tomar berberina, hable con su médico si está tomando medicamentos que son modificados por el hígado.
P Algunos medicamentos modificados por el hígado incluyen ciclosporina (Neoral, Sandimmune), lovastatina (Mevacor), claritromicina (Biaxin), indinavir (Crixivan), sildenafilo (Viagra), triazolam (Halcion) y muchos otros.
P Medicamentos modificados por el hígado (Sustratos del Citocromo P450 2C9 [CYP2C9])
P Algunos medicamentos son alterados y descompuestos por el hígado. La berberina podría disminuir la velocidad con la que hígado descompone ciertos medicamentos. La ingesta de berberina junto con algunos medicamentos que son modificados por el hígado podría aumentar los efectos y los efectos secundarios de algunos medicamentos. Antes de ingerir berberina, consulte con su proveedor de salud si toma medicamentos que son alterados por el hígado.
P Algunos medicamentos modificados por el hígado incluyen celecoxib (Celebrex), diclofenac (Voltaren), fluvastatina (Lescol), glipizida (Glucotrol), ibuprofeno (Advil, Motrin), irbesartano (Avapro), losartan (Cozaar), fenitoína (Dilantin), piroxicam (Feldene), tamoxifeno (Nolvadex), tolbutamida (Tolinase), torsemida (Demadex), y S-warfarina (Coumadin).
P Medicamentos modificados por el hígado (Sustratos del Citocromo P450 2D6 [CYP2D6])
P Algunos medicamentos son alterados y descompuestos por el hígado. La berberina podría disminuir la velocidad con la que hígado descompone ciertos medicamentos. La ingesta de berberina junto con algunos medicamentos que son modificados por el hígado podría aumentar los efectos y los efectos secundarios de algunos medicamentos. Antes de ingerir berberina, consulte con su proveedor de salud si toma medicamentos que son alterados por el hígado.
P Algunos medicamentos modificados por el hígado incluyen amitriptilina (Elavil), codeína, desipramina (Norpramin), flecainida (Tambocor), haloperidol (Haldol), imipramina (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetina (Paxil), risperidona (Risperdal), tramadol (Ultram), venlafaxina (Effexor), entre otros.
P Medicamentos para la presión arterial alta (medicamentos antihipertensivos)
P La berberina podría disminuir la presión arterial en ciertas personas. La ingesta de berberina junto con medicamentos para la diabetes podría causar una marcada disminución de los niveles de azúcar en la sangre. Sin embargo, no es claro si esto representa un problema grave. No ingerir demasiado berberina si toma medicamentos para la presión arterial alta.
P Algunos medicamentos para la presión arterial incluyen captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipina (Norvasc), hidroclorotiazida (HydroDIURIL), furosemida (Lasix) entre otros.
P Medicamentos que disminuyen la coagulación de la sangre (Anticoagulantes / Antiplaquetarios)
P La berberina podría disminuir la coagulación de la sangre. La ingesta de berberina junto con otros medicamentos que también disminuyen la coagulación podría reducir la probabilidad de sufrir hematomas y hemorragia.
P Algunos medicamentos que disminuyen la coagulación de la sangre incluyen aspirina, cilostazol (Pletal), clopidogrel (Plavix), dalteparina (Fragmin), enoxaparina (Lovenox), heparina, ticlopidina (Ticlid), entre otros.
P Medicamentos sedantes (depresores del SNC)
P La berberina podría causar adormecimiento y somnolencia. Los medicamentos que causan adormecimiento se denominan sedantes. La ingesta de berberina junto con sedantes podría causar demasiado adormecimiento.
P Algunos sedantes incluidas las benzodiacepinas, pentobarbital (Nembutal), fenobarbital (Luminal), secobarbital (Seconal), tiopental (Pentotal), fentanil (Duragesic, Sublimaze), morfina,propofol (Diprivan) y otros.
P Midazolam (Versed)
P El cuerpo descompone el midazolam (Versed) a fin de eliminarlo. La berberina puede disminuir la velocidad con la que hígado descompone el midazolam (Versed). La ingesta de berberina junto con midazolam (Versed) podría aumentar los efectos y los efectos secundarios del midazolam (Versed).

T ¿Existen interacciones con hierbas y suplementos?
P Hierbas y suplementos con propiedades sedantes
P La berberina puede causar adormecimiento y somnolencia. Si se lo ingiere junto con otras hierbas y suplementos que tienen el mismo efecto podría causar demasiado sueño. Algunas de estas hierbas y suplementos incluyen cálamo, amapola de California, hierba gatera, lúpulo, guamá, kava, L-triptofano, melatonina, salvia, SAMe, hierba de San Juan, sassafras, escutelaria, entre otros.
P Hierbas y suplementos que podrían disminuir la coagulación de la sangre
P La berberina podría disminuir la coagulación de la sangre. La ingesta de berberina junto con otras hierbas que podrían disminuir la coagulación podría aumentar la probabilidad de hematomas y hemorragia. Estas hierbas incluyen angélica, clavo de olor, danshen, ajo, jengibre, ginkgo (Ginkgo biloba), Panax ginseng, entre otros.
P Hierbas y suplementos que podrían disminuir la presión arterial
P La berberina podría disminuir la presión arterial. Si se lo ingiere junto con otras hierbas y suplementos que tienen el mismo efecto podría causar una marcada disminución de la presión arterial en ciertas personas. Algunos de estos productos incluyen andrographis, péptidos de caseína, uña de gato, coenzima Q10, aceite de pescado, L-arginina, licio, ortiga brava, teanina y otros.
P Hierbas y suplementos que podrían disminuir los niveles de azúcar en sangre
P La berberina podría disminuir los niveles de azúcar en la sangre. Si se lo ingiere junto con otras hierbas y suplementos que tienen el mismo efecto podría causar una marcada disminución de los niveles de azúcar en la sangre en ciertas personas. Algunos de estos productos incluyen ácido alfa lipoico, melón amargo, cromo, garra del diablo, alholva, ajo, goma guar, castaño de Indias, Panax ginseng, psilio, ginseng siberiano y entre otros.

T ¿Existen interacciones con alimentos?
P No se conoce ninguna interacción con alimentos.

T ¿Qué dosis se utiliza?
P La dosis apropiada de berberina depende de muchos factores tales como la edad de la persona, el estado de salud y varias otras condiciones. En este momento no hay suficiente información científica para determinar un rango de dosis apropiado para el uso de la berberina Tenga en cuenta que los productos naturales no son siempre necesariamente seguros y las dosis pueden ser importantes. Asegúrese de seguir las instrucciones en las etiquetas de los productos y consulte con su farmacéutico, doctor u otro proveedor de salud médica antes de usarlos.

T Otros nombres
P Alcaloïde de Berbérine, Berbérine, Berberine Alkaloid, Berberine Complex, Berberine Sulfate, Sulfate de Berbérine.

T Metodología
P Para saber más sobre cómo este artículo fue escrito, refiérase a la metodología de la Base exhaustiva de datos de medicamentos naturales.

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- Salt, I. P. and Palmer, T. M. Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert.Opin.Investig.Drugs 2012;21:1155-1167. View abstract.
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- Zhang, J., Zhou, F., Lu, M., Ji, W., Niu, F., Zha, W., Wu, X., Hao, H., and Wang, G. Pharmacokinetics-pharmacology disconnection of herbal medicines and its potential solutions with cellular pharmacokinetic-pharmacodynamic strategy. Curr Drug Metab 6-1-2012;13:558-576. View abstract.
- Carlomagno, G., Pirozzi, C., Mercurio, V., Ruvolo, A., and Fazio, S. Effects of a nutraceutical combination on left ventricular remodeling and vasoreactivity in subjects with the metabolic syndrome. Nutr Metab Cardiovasc.Dis 2012;22:e13-e14. View abstract.
- Vy Thi, Le T., Han, S., Chae, J., and Park, H. J. G-quadruplex binding ligands: from naturally occurring to rationally designed molecules. Curr Pharm Des 2012;18:1948-1972. View abstract.
- Cianci, A., Cicero, A. F., Colacurci, N., Matarazzo, M. G., and De, Leo, V. Activity of isoflavones and berberine on vasomotor symptoms and lipid profile in menopausal women. Gynecol.Endocrinol. 2012;28:699-702. View abstract.
- Xie, X., Meng, X., Zhou, X., Shu, X., and Kong, H. [Research on therapeutic effect and hemorrheology change of berberine in new diagnosed patients with type 2 diabetes combining nonalcoholic fatty liver disease]. Zhongguo Zhong Yao Za Zhi 2011;36:3032-3035. View abstract.
- Meng, S., Wang, L. S., Huang, Z. Q., Zhou, Q., Sun, Y. G., Cao, J. T., Li, Y. G., and Wang, C. Q. Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention. Clin Exp.Pharmacol Physiol 2012;39:406-411. View abstract.
- Kim, H. S., Kim, M. J., Kim, E. J., Yang, Y., Lee, M. S., and Lim, J. S. Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. Biochem.Pharmacol 2-1-2012;83:385-394. View abstract.
- Marazzi, G., Cacciotti, L., Pelliccia, F., Iaia, L., Volterrani, M., Caminiti, G., Sposato, B., Massaro, R., Grieco, F., and Rosano, G. Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients. Adv.Ther 2011;28:1105-1113. View abstract.
- Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol. 2012;166:99-105. View abstract.
- Wang, Q., Zhang, M., Liang, B., Shirwany, N., Zhu, Y., and Zou, M. H. Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. PLoS.One. 2011;6:e25436. View abstract.
- Tan, W., Li, Y., Chen, M., and Wang, Y. Berberine hydrochloride: anticancer activity and nanoparticulate delivery system. Int J Nanomedicine. 2011;6:1773-1777. View abstract.
- Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68:213-217. View abstract.
- Wang, T., Wang, N., Song, H., Xi, X., Wang, J., Hao, A., and Li, T. Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine. Eur J Pharm Sci 9-18-2011;44(1-2):127-135. View abstract.
- Lamb, J. J., Holick, M. F., Lerman, R. H., Konda, V. R., Minich, D. M., Desai, A., Chen, T. C., Austin, M., Kornberg, J., Chang, J. L., Hsi, A., Bland, J. S., and Tripp, M. L. Nutritional supplementation of hop rho iso-alpha acids, berberine, vitamin D, and vitamin K produces a favorable bone biomarker profile supporting healthy bone metabolism in postmenopausal women with metabolic syndrome. Nutr Res 2011;31:347-355. View abstract.
- Xia, X., Yan, J., Shen, Y., Tang, K., Yin, J., Zhang, Y., Yang, D., Liang, H., Ye, J., and Weng, J. Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis. PLoS.One. 2011;6:e16556. View abstract.
- Guan, S., Wang, B., Li, W., Guan, J., and Fang, X. Effects of berberine on expression of LOX-1 and SR-BI in human macrophage-derived foam cells induced by ox-LDL. Am J Chin Med 2010;38:1161-1169. View abstract.
- Zhao, L., Li, W., Han, F., Hou, L., Baillargeon, J. P., Kuang, H., Wang, Y., and Wu, X. Berberine reduces insulin resistance induced by dexamethasone in theca cells in vitro. Fertil.Steril. 2011;95:461-463. View abstract.
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- Hu, Y., Kutscher, E., and Davies, G. E. Berberine inhibits SREBP-1-related clozapine and risperidone induced adipogenesis in 3T3-L1 cells. Phytother.Res 2010;24:1831-1838. View abstract.
- Wang, Y., Campbell, T., Perry, B., Beaurepaire, C., and Qin, L. Hypoglycemic and insulin-sensitizing effects of berberine in high-fat diet- and streptozotocin-induced diabetic rats. Metabolism 2011;60:298-305. View abstract.
- Gu, Y., Zhang, Y., Shi, X., Li, X., Hong, J., Chen, J., Gu, W., Lu, X., Xu, G., and Ning, G. Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics. Talanta 5-15-2010;81:766-772. View abstract.
- Liu, L., Yu, Y. L., Yang, J. S., Li, Y., Liu, Y. W., Liang, Y., Liu, X. D., Xie, L., and Wang, G. J. Berberine suppresses intestinal disaccharidases with beneficial metabolic effects in diabetic states, evidences from in vivo and in vitro study. Naunyn Schmiedebergs Arch Pharmacol 2010;381:371-381. View abstract.
- Liu, L. Z., Cheung, S. C., Lan, L. L., Ho, S. K., Xu, H. X., Chan, J. C., and Tong, P. C. Berberine modulates insulin signaling transduction in insulin-resistant cells. Mol.Cell Endocrinol. 4-12-2010;317(1-2):148-153. View abstract.
- Holick, M. F., Lamb, J. J., Lerman, R. H., Konda, V. R., Darland, G., Minich, D. M., Desai, A., Chen, T. C., Austin, M., Kornberg, J., Chang, J. L., Hsi, A., Bland, J. S., and Tripp, M. L. Hop rho iso-alpha acids, berberine, vitamin D3 and vitamin K1 favorably impact biomarkers of bone turnover in postmenopausal women in a 14-week trial. J Bone Miner.Metab 2010;28:342-350. View abstract.
- Hwang, J. T., Kwon, D. Y., and Yoon, S. H. AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols. N.Biotechnol. 10-1-2009;26(1-2):17-22. View abstract.
- Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Metabolism 2010;59:285-292. View abstract.
- Wang, Y., Jia, X., Ghanam, K., Beaurepaire, C., Zidichouski, J., and Miller, L. Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters. Atherosclerosis 2010;209:111-117. View abstract.
- Li, G. H., Wang, D. L., Hu, Y. D., Pu, P., Li, D. Z., Wang, W. D., Zhu, B., Hao, P., Wang, J., Xu, X. Q., Wan, J. Q., Zhou, Y. B., and Chen, Z. T. Berberine inhibits acute radiation intestinal syndrome in human with abdomen radiotherapy. Med Oncol. 2010;27:919-925. View abstract.
- Affuso, F., Ruvolo, A., Micillo, F., Sacca, L., and Fazio, S. Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutr Metab Cardiovasc.Dis 2010;20:656-661. View abstract.
- Wang, C., Li, J., Lv, X., Zhang, M., Song, Y., Chen, L., and Liu, Y. Ameliorative effect of berberine on endothelial dysfunction in diabetic rats induced by high-fat diet and streptozotocin. Eur J Pharmacol 10-12-2009;620(1-3):131-137. View abstract.
- Al-masri, I. M., Mohammad, M. K., and Tahaa, M. O. Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine. J Enzyme Inhib.Med Chem 2009;24:1061-1066. View abstract.
- Wang, J. M., Yang, Z., Xu, M. G., Chen, L., Wang, Y., Su, C., and Tao, J. Berberine-induced decline in circulating CD31+/. Eur J Pharmacol 7-1-2009;614(1-3):77-83. View abstract.
- Jeong, H. W., Hsu, K. C., Lee, J. W., Ham, M., Huh, J. Y., Shin, H. J., Kim, W. S., and Kim, J. B. Berberine suppresses proinflammatory responses through AMPK activation in macrophages. Am J Physiol Endocrinol.Metab 2009;296:E955-E964. View abstract.
- Kim, W. S., Lee, Y. S., Cha, S. H., Jeong, H. W., Choe, S. S., Lee, M. R., Oh, G. T., Park, H. S., Lee, K. U., Lane, M. D., and Kim, J. B. Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity. Am J Physiol Endocrinol.Metab 2009;296:E812-E819. View abstract.
- Kong, W. J., Zhang, H., Song, D. Q., Xue, R., Zhao, W., Wei, J., Wang, Y. M., Shan, N., Zhou, Z. X., Yang, P., You, X. F., Li, Z. R., Si, S. Y., Zhao, L. X., Pan, H. N., and Jiang, J. D. Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression. Metabolism 2009;58:109-119. View abstract.
- Jung, H. A., Yoon, N. Y., Bae, H. J., Min, B. S., and Choi, J. S. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res 2008;31:1405-1412. View abstract.
- Lu, S. S., Yu, Y. L., Zhu, H. J., Liu, X. D., Liu, L., Liu, Y. W., Wang, P., Xie, L., and Wang, G. J. Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats. J Endocrinol. 2009;200:159-165. View abstract.
- Liu, Y., Yu, H., Zhang, C., Cheng, Y., Hu, L., Meng, X., and Zhao, Y. Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung cancer. Eur J Cancer 2008;44:2425-2432. View abstract.
- Liu, W. H., Hei, Z. Q., Nie, H., Tang, F. T., Huang, H. Q., Li, X. J., Deng, Y. H., Chen, S. R., Guo, F. F., Huang, W. G., Chen, F. Y., and Liu, P. Q. Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase. Chin Med J (Engl.) 4-20-2008;121:706-712. View abstract.
- Kong, W. J., Wei, J., Zuo, Z. Y., Wang, Y. M., Song, D. Q., You, X. F., Zhao, L. X., Pan, H. N., and Jiang, J. D. Combination of simvastatin with berberine improves the lipid-lowering efficacy. Metabolism 2008;57:1029-1037. View abstract.
- Yang, Z., Shao, Y. C., Li, S. J., Qi, J. L., Zhang, M. J., Hao, W., and Jin, G. Z. Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: a pilot study. Acta Pharmacol Sin. 2008;29:781-788. View abstract.
- Zhou, J. Y., Zhou, S. W., Zhang, K. B., Tang, J. L., Guang, L. X., Ying, Y., Xu, Y., Zhang, L., and Li, D. D. Chronic effects of berberine on blood, liver glucolipid metabolism and liver PPARs expression in diabetic hyperlipidemic rats. Biol Pharm Bull. 2008;31:1169-1176. View abstract.
- Liu, W., Liu, P., Tao, S., Deng, Y., Li, X., Lan, T., Zhang, X., Guo, F., Huang, W., Chen, F., Huang, H., and Zhou, S. F. Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose. Arch Biochem.Biophys. 7-15-2008;475:128-134. View abstract.
- Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57:712-717. View abstract.
- Kalman, D. S., Feldman, S., Feldman, R., Schwartz, H. I., Krieger, D. R., and Garrison, R. Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J 2008;7:11. View abstract.
- Zhang, Y., Li, X., Zou, D., Liu, W., Yang, J., Zhu, N., Huo, L., Wang, M., Hong, J., Wu, P., Ren, G., and Ning, G. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol.Metab 2008;93:2559-2565. View abstract.
- Xu, M. G., Wang, J. M., Chen, L., Wang, Y., Yang, Z., and Tao, J. Berberine-induced mobilization of circulating endothelial progenitor cells improves human small artery elasticity. J Hum.Hypertens 2008;22:389-393. View abstract.
- Yin, J., Gao, Z., Liu, D., Liu, Z., and Ye, J. Berberine improves glucose metabolism through induction of glycolysis. Am J Physiol Endocrinol.Metab 2008;294:E148-E156. View abstract.
- Cheng, Z., Pang, T., Gu, M., Gao, A. H., Xie, C. M., Li, J. Y., Nan, F. J., and Li, J. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim.Biophys.Acta 2006;1760:1682-1689. View abstract.
- Zuo, F., Nakamura, N., Akao, T., and Hattori, M. Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry. Drug Metab Dispos. 2006;34:2064-2072. View abstract.
- Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Ye, J. M., Lee, C. H., Oh, W. K., Kim, C. T., Hohnen-Behrens, C., Gosby, A., Kraegen, E. W., James, D. E., and Kim, J. B. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006;55:2256-2264. View abstract.
- Xin, H. W., Wu, X. C., Li, Q., Yu, A. R., Zhong, M. Y., and Liu, Y. Y. The effects of berberine on the pharmacokinetics of cyclosporin A in healthy volunteers. Methods Find.Exp.Clin Pharmacol 2006;28:25-29. View abstract.
- Mantena, S. K., Sharma, S. D., and Katiyar, S. K. Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol Cancer Ther 2006;5:296-308. View abstract.
- Lin, C. C., Kao, S. T., Chen, G. W., Ho, H. C., and Chung, J. G. Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer Res 2006;26(1A):227-242. View abstract.
- Lin, J. P., Yang, J. S., Lee, J. H., Hsieh, W. T., and Chung, J. G. Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line. World J Gastroenterol. 1-7-2006;12:21-28. View abstract.
- Kim, H. R., Min, H. Y., Jeong, Y. H., Lee, S. K., Lee, N. S., and Seo, E. K. Cytotoxic constituents from the whole plant of Corydalis pallida. Arch Pharm Res 2005;28:1224-1227. View abstract.
- Lin, C. C., Kao, S. T., Chen, G. W., and Chung, J. G. Berberine decreased N-acetylation of 2-aminofluorene through inhibition of N-acetyltransferase gene expression in human leukemia HL-60 cells. Anticancer Res 2005;25(6B):4149-4155. View abstract.
- Inoue, K., Kulsum, U., Chowdhury, S. A., Fujisawa, S., Ishihara, M., Yokoe, I., and Sakagami, H. Tumor-specific cytotoxicity and apoptosis-inducing activity of berberines. Anticancer Res 2005;25(6B):4053-4059. View abstract.
- Abidi, P., Zhou, Y., Jiang, J. D., and Liu, J. Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine. Arterioscler.Thromb.Vasc.Biol 2005;25:2170-2176. View abstract.
- Lee, S., Lim, H. J., Park, H. Y., Lee, K. S., Park, J. H., and Jang, Y. Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model. Atherosclerosis 2006;186:29-37. View abstract.
- Doggrell, S. A. Berberine--a novel approach to cholesterol lowering. Expert.Opin.Investig.Drugs 2005;14:683-685. View abstract.
- Kuo, C. L., Chi, C. W., and Liu, T. Y. Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. In Vivo 2005;19:247-252. View abstract.
- Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., Wang, S., Wu, J., Wang, Y., Li, Z., Liu, J., and Jiang, J. D. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med 2004;10:1344-1351. View abstract.
- Yount, G., Qian, Y., Moore, D., Basila, D., West, J., Aldape, K., Arvold, N., Shalev, N., and Haas-Kogan, D. Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitro. J Exp Ther Oncol. 2004;4:137-143. View abstract.
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- Sriwilaijareon, N., Petmitr, S., Mutirangura, A., Ponglikitmongkol, M., and Wilairat, P. Stage specificity of Plasmodium falciparum telomerase and its inhibition by berberine. Parasitol.Int 2002;51:99-103. View abstract.
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