Hydroxyzine: MedlinePlus Drug Information

T Why is this medication prescribed?
P Hydroxyzine is used in adults and children to relieve itching caused by allergic skin reactions. It is also used alone or with other medications in adults and children to relieve anxiety and tension. Hydroxyzine is also used along with other medications in adults and children as a sedative before and after general anesthesia for surgery. Hydroxyzine is in a class of medications called antihistamines. It works by blocking the action of histamine a substance in the body that causes allergic symptoms. It also works by decreasing activity in the brain.

T How should this medicine be used?
P Hydroxyzine comes as capsules, tablets, a syrup, and suspension to take by mouth. It usually is taken three or four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take hydroxyzine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
P Shake the suspension well before each use to mix the medication evenly.

T Other uses for this medicine
P This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

T What special precautions should I follow?
t Before taking hydroxyzine,
- tell your doctor and pharmacist if you are allergic to hydroxyzine, cetirizine (Zyrtec), levocetirizine (Xyzal), any other medications, or any of the ingredients in hydroxyzine preparations. Ask your doctor or pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: antihistamines; azithromycin (Zithromax, ZMax), certain antidepressants such as citalopram (Celexa) and fluoxetine (Prozac, Sarafem, Selfemra); medications for anxiety; certain medications for arrhythmias such as amiodarone (Cordarone, Nexterone, Pacerone, ), procainamide, quinidine (in Nuedexta), and sotalol (Betapace, Sorine, Sotylize); barbiturates; clarithromycin (Biaxin, in Prevpac); droperidol (Inapsine); erythromycin (Eryc, Ery-Tab, PCE, others); gatifloxacin; certain medications for mental illness such as chlorpromazine, clozapine (Clozaril, Fazaclo ODT, Versacloz), iloperidone (Fanapt), quetiapine (Seroquel), and ziprasidone (Geodon); meperidine (Demerol); methadone (Dolophine, Methadose); moxifloxacin (Avelox); medications for pain; ondansetron (Zofran, Zuplenz); pentamidine (Nebupent, Pentam); and medications for seizures, sedatives, sleeping pills, and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death) or if you plan to be pregnant or are pregnant. Your doctor will probably tell you not to take hydroxyzine.
- tell your doctor if anyone in your family has or has ever had a prolonged QT interval or if you have or have ever had a slow or irregular heartbeat, low blood levels of potassium or magnesium, heart failure, a heart attack, or heart disease.
- tell your doctor if you are breastfeeding. Do not breastfeed while taking hydroxyzine.
- talk to your doctor about the risks and benefits of taking hydroxyzine if you are 65 years of age or older. Older adults should not usually take hydroxyzine because it is not as safe as other medications that can be used to treat the same condition.
- you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
- ask your doctor about the safe use of alcohol while you are taking this medication. Alcohol can make the side effects of hydroxyzine worse.

T What special dietary instructions should I follow?
P Unless your doctor tells you otherwise, continue your normal diet.

T What should I do if I forget a dose?
P If your doctor has told you to take hydroxyzine regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

T What side effects can this medication cause?
t Hydroxyzine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- dry mouth
- constipation (especially in older adults)
- confusion (especially in older adults)
- dizziness
- headache
t Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
- unintentional trembling or shaking movements
- seizures
t If you experience any of the following symptoms of a serious skin condition; stop taking hydroxyzine and call your doctor immediately:
- rash
- pus-filled, blister-like sores (lesions), areas of swelling and redness on the skin, and fever
P Hydroxyzine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
P If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

T What should I know about storage and disposal of this medication?
P Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).
P Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
P It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

T In case of emergency/overdose
P In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
t Symptoms of overdose may include the following:
- sedation
- dizziness
- seizures
- nausea
- vomiting

T What other information should I know?
P Keep all appointments with your doctor.
P Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
P It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
P 

T Brand names
- Atarax®¶
- Hypam®¶
- Orgatrax®¶
- Vistaril®

