L-Arginina: MedlinePlus suplementos

T ¿Qué es?
P La L-arginina es un bloque químico fundamental llamado "aminoácido". Se obtiene a partir de la dieta y es necesaria para el cuerpo para hacer las proteínas. La L-arginina se encuentra en la carne roja, en la carne de aves y los productos lácteos. También se puede hacer en el laboratorio y usar como medicamento.
P La L-arginina se utiliza para afecciones del corazón y vasos sanguíneos incluyendo la insuficiencia cardiaca congestiva (CHF), el dolor de pecho, la presión arterial alta y las enfermedades de las arterias coronarias. La L-arginina también se usa para el dolor recurrente en las piernas debido a arterias que están bloqueadas (claudicación intermitente), para el tratamiento de la disminución de la capacidad mental en los ancianos (demencia senil), para la disfunción eréctil (DE) y la infertilidad masculina.
P Algunas personas usan la L-arginina para la prevención del resfrío común, para mejorar el funcionamiento de los riñones después de un transplante de riñón, para la presión arterial alta durante el embarazo (preeclampsia), para mejorar el rendimiento atlético, para aumentar el sistema inmunológico y para prevenir la inflamación del tracto digestivo en los infantes prematuros.
P La L-arginina se utiliza en combinación con un gran número de medicamentos que se venden con o sin receta médica y que se utilizan para distintas afecciones. Por ejemplo, la L-arginina se usa junto con ibuprofeno para los dolores de cabeza de migraña; junto con los fármacos convencionales que se usan en los tratamientos de quimioterapia para el cáncer de mamas; junto con otros aminoácidos para el tratamiento de la pérdida de peso en los pacientes con SIDA; y junto con aceite de pescado y otros suplementos para disminuir las infecciones, mejorar la cicatrización de las heridas y acortar el tiempo necesario para la recuperación después de una cirugía.
P Algunas personas aplican la L-arginina a la piel para acelerar la cicatrización de las heridas y para aumentar el flujo de sangre a las manos y pies helados, especialmente en las personas con diabetes. También se usa como una crema para los problemas sexuales tanto en los hombres como en las mujeres.

T ¿Qué tan efectivo es?
P Natural Medicines Comprehensive Database (La Base Exhaustiva de Datos de Medicamentos Naturales) clasifica la eficacia, basada en evidencia científica, de acuerdo a la siguiente escala: Eficaz, Probablemente Eficaz, Posiblemente Eficaz, Posiblemente Ineficaz, Probablemente Ineficaz, Ineficaz, e Insuficiente Evidencia para Hacer una Determinación.
P La clasificación de la eficacia para este producto es la siguiente:
t Posiblemente eficaz para...
- Dolor de pecho (angina). La ingesta de L-arginine parece reducir los síntomas y mejorar la tolerancia al ejercicio físico y la calidad de vida en personas con angina de pecho. Sin embargo, la L-arginina no parece mejorar la enfermedad misma.
- Disfunción eréctil (DE). La ingesta diaria de 5 gramos de L-arginina parece mejorar la función sexual en hombres con DE. La ingesta de dosis bajas podrían no tener efecto. Sin embargo, existe cierta evidencia que muestra que agregar 40 mg de Pycnogenol tres veces por día podría mejorar la efectividad de la dosis baja de L-arginine para tratar la DE.
- Hipertensión arterial. Existe cierta evidencia que muestra que la ingesta de L-arginine puede reducir la hipertensión arterial en personas sanas, hipertensas y con presion arterial levemente alta con o sin diabetes.
- Inflamación de las vías digestivas en bebés prematuros. Agregar L-arginine a la leche maternizada parece prevenir la inflamación de las vías digestivas en bebés prematuros.
- Intolerancia al nitrato. La ingesta de 700 mg de L-arginine cuatro veces por día parece prevenir la intolerancia al nitrato en personas que toman nitroglicerina ara tratar la angina de pecho.
- Dolor en las piernas asociado con mala irrigación sanguínea (vasculopatía periférica). La investigación sugiere que la ingesta de L-arginine o por vía intravenosa (VI) durante un máximo de ocho semanas mejora la irrigación sanguínea en personas con vasculopatía periférica. Sin embargo, su uso prolongado (hasta un máximo de seis meses) no mejora los problemas ni la velocidad para caminar en personas con vasculopatía periférica.
- Mejorar la recuperación después de una cirugía. El tomar L-arginina con ácido ribonucleico (ARN) y ácido eicopentaénoico (EPA) antes o después de una cirugía parece ayudar a disminuir el tiempo de recuperación, disminuir el número de infecciones y mejorar la cicatrización de las heridas después de la cirugía.
- Hipertensión arterial durante el embarazo (preeclampsia). Aunque son contradictorios los resultados sobre los efectos de la L-arginine para tratar la preeclampsia, la mayoría de la investigación sugiere que puede disminuir la presión arterial en mujeres con esta condición.
t Posiblemente ineficaz para...
- Enfermedad renal. La mayoría de la investigación sugiere que la L-arginine, ya sea ingerida durante un máximo de seis meses o por via intravenosa (VI) durante un breve tiempo, no mejora la función renal en personas con insuficiencia renal o enfermedad renal. Sin embargo, la ingesta de 1,3 gramos de L-arginina parece mejorar la función renal y detener la anemia en personas ancianas con anemia asociada con enfermedad renal.
- Ataque al corazón. El tomar L-arginina no parece ayudar a prevenir un ataque al corazón. Además, no parece ser beneficioso para el tratamiento del ataque al corazón después que este ya ha ocurrido. De hecho, hay preocupación de que la L-arginina podría producir daño después de un reciente ataque al corazón. No tome L-arginina si ha tenido un ataque al corazón recientemente.
- Cicatrización de las heridas. La ingesta de L-arginina no parece mejorar la cicatrización de las heridas.
t Insuficiente evidencia para hacer una determinación para...
- Adelgazamiento relacionado con SIDA. La ingesta de L-arginina junto con hidroximetilbutirato (HMB) y glutamina durante ochos semanas parece aumentar el peso corporal y mejorar la función inmunitaria en personas con VIH/SIDA. Sin embargo, la ingesta diaria de 7,4 gramos de L-arginina junto con ácidos grasos omega 3 y un suplemento nutricional equilibrado durante seis meses no mejora el peso corporal o la masa grasa, el aporte energético y la función inmunitaria en personas con VIH positivo.
- Mal de las alturas. La investigación sugiere que la L-arginina no reduce el mal de las alturas.
- Fisuras anales. Es contradictoria la evidencia sobre la efectividad de la L-arginina para tratar las fisuras anales. La aplicación de L-arginina en la piel dos veces por día durante tres meses es menos efectiva que la cirugía por fisura anal. Sin embargo, la aplicación de un gel tópico que contiene L-arginina cinco veces por día al menos durante 12 semanas podría curar las fisuras anales en personas que no responden al tratamiento tradicional.
- Cáncer de mama. La investigación preliminar muestra que la ingesta de L-arginina antes de la quimioterapia no mejora la tasa de respuesta en personas con cáncer de mama.
- Efectos secundarios de la quimioterapia. La investigación preliminar muestra que la ingesta de L-arginina antes de comenzar la quimioterapia puede prevenir la disminución de la actividad del sistema inmunitario asociada con el tratamiento de quimioterapia en personas con cáncer de mama.
- Insuficiencia cardíaca congestiva. La ingesta de L-arginina junto con un tratamiento tradicional parce mejorar la función renal n personas con Insuficiencia cardíaca. No obstante podría mejorar la capacidad física, la calidad de vida y la circulación sanguínea. La L-arginina debería usarse con precaución en personas con cirrosis.
- Obstrucción arterial (arteriopatía coronaria). La investigación preliminar sugiere que la ingesta de L-arginina o por vía intravenosa (VI) antes de realizar actividad física mejora la función arterial en personas con coronaria. Sin embargo, no mejora la irrigación sanguínea al corazón.
- Enfermedad grave (traumatismo). La investigación muestra que la ingesta de L-arginina con glutamina, nucleótidos y ácidos grasos omega 3 reduce el tiempo de recuperación, la necesidad de ventilación y el riesgo de infecciones en personas con enfermedad grave; sin embargo, no reduce el riesgo de muerte.
- Pérdida de memoria (demencia). La investigación preliminar sugiere que la L-arginina podría mejorar la pérdida de la memoria relacionada con el envejecimiento.
- Cavidades bucales. La investigación preliminar sugiere que el uso de menta sin azúcar que contiene un complejo de arginina (CaviStat) durante un año reduce el número de cavidades en molares de niños en comparación con las mentas sin azúcar que no contiene arginina.
- Dientes sensibles. La investigación preliminar sugiere que el uso de una pasta dental que contiene arginina, calcio y flúor reduce la sensibilidad de los dientes cuando se lo usa dos veces al día.
- Diabetes. La ingesta de L-arginina durante un mes parece mejorar el control de los niveles de azúcar en la sangre en personas con diabetes. La L-arginina también parece mejorar la sensibilidad de la insulina y la presion sanguínea en personas con diabetes tipo 2.
- Úlceras del pie diabético. La investigación preliminar muestra que la aplicación diaria de L-arginina para tratar el pie puede mejorar la circulación en personas con diabetes, lo que podría ser beneficioso para prevenir las úlceras del pie diabético. Sin embargo si ya existe una úlcera en el pie, las inyecciones con L-arginina debajo de la piel cerca de la úlcera no parecen acortar el tiempo de cicatrización o disminuir la probabilidad de recurrir a una amputación en el futuro.
- Daño al sistema nervioso debido a la diabetes. La investigación preliminar sugiere que la ingesta diaria de L-arginina durante tres meses no mejora el daño al sistema nervioso relacionado con la diabetes.
- Problemas musculares en el esófago. La investigación preliminar sugiere que una infusión de L-arginina y la ingesta de L-arginina durante seis semanas reduce el número y la intensidad de los ataques de dolor en el pecho en personas con problemas musculares en el esófago y el dolor en el pecho no relacionado con el corazón.
- Rendimiento atlético. Es contradictoria la evidencia sobre la efectividad de la of L-arginina en el rendimiento del ejercicio físico. Cierta evidencia muestra que la ingesta de seis gramos de L-arginina en una bebida mejora el tiempo de ejercicio de ejercicio. Sin embargo, otra evidencia sugiere que la ingesta de L-arginina de manera aislada o junto con antioxidantes (Niteworks, Herbalife International, Inc) no mejora el rendimiento en hombres ciclistas.
- Cáncer de cabeza y cuello. El suministro de suplementos con L-arginina a través de una sonda nasogástrica no parece mejorar la función inmunitaria, reducir el tamaño del tumor o mejorar la cicatrización en personas con cáncer de cabeza y cuello.
- Cirugía de derivación aortocoronaria (CABG). Es contradictoria la evidencia sobre la efectividad de la of L-arginina para proteger al corazón durante una CABG. La investigación preliminar sugiere que la administración de L-arginina por vía intravenosa (VI) ayuda a mantener la presión arterial y la irrigación sanguínea en personas sometidas a una CABG. Sin embargo, no reduce las complicaciones después de la cirugía o el tiempo de permanencia en el hospital.
- Trasplante de corazón. Algunos estudios sugieren que la ingesta diaria de L-arginina durante 6 semanas mejora la distancia de recorrido y mejora la respiración en personas con transplante de corazón.
- Colesterol alto. La evidencia preliminar muestra que la ingesta diaria de L-arginina durante cuatro semanas no reduce los niveles de grasa en sangre en personas con niveles altos de colesterol.
- Infertilidad. Es contradictoria la evidencia sobre la efectividad de la of L-arginina en el rendimiento del ejercicio físico. Cierta evidencia muestra que la ingesta diaria de seis gramos de L-arginina aumenta el recuento de óvulos recogidos en una mujer sometida a fertilización in vitro (FIV). Sin embargo, no parece mejorar las tasas de embarazo. Otra investigación sugiere que la ingesta de L-arginina no mejora la calidad del semen en hombres con infertilidad inexplicada.
- Inflamación de la vejiga. La ingesta de L-arginina parece reducir el dolor y ciertos síntomas de inflamación de la vejiga, aunque las mejorías podrían observarse a los tres meses. Sin embargo, la L-arginina no parece reducir la necesidad de orinar durante la noche o mejorar la frecuencia de la micción.
- Alteraciones en el crecimiento fetal durante el embarazo. La investigación preliminar sugiere que la ingesta de L-arginina durante el embarazo puede aumentar el peso de los bebés con alteraciones en el crecimiento mientras están en el útero materno. Sin embargo, la L-arginina no parece mejorar el peso al nacer o reducir el riesgo de mortalidad si el bebé tiene un peso extremadamente bajo mientras está en el útero materno.
- Condición genética que afecta muchos sistemas del cuerpo humano (síndrome MELAS). Existe cierto interés en usar la L-arginina para mejorar los síntomas asociados con el síndrome MELAS. La investigación preliminar sugiere que la administración de L-arginina por vía intravenosa (VI) dentro de la hora posterior a la aparición de los síntomas parecidos a un accidente cerebrovascular mejora las cefaleas, náuseas, vómitos, ceguera y la aparición de destellos de luz.
- Cefalea por migraña. La ingesta de L-arginina junto con el analgésico ibuprofeno parece ser efectiva para el tratamiento de la cefalea por migraña. Esta combinación a veces comienza a hacer efecto a los 30 minutos. Sin embargo, es difícil saber la magnitud del alivio del dolor que otorga la L-arginina dado que el ibuprofeno puede aliviar por si solo el dolor por migraña.
- Enfermedad ovárica (síndrome ovárico poliquístico). La investigación preliminar sugiere que la ingesta diaria de N-acetil cisteína y L-arginina durante seis meses puede mejorar la función menstrual y reducir la resistencia a la insulina en personas con síndrome ovárico poliquístico.
- Úlceras por presión. La evidencia preliminar sugiere que la ingesta diaria de un suplemento que contiene proteínas, energía, arginina, vitamina C y cinc durante nueve semanas puede reducir el tamaño de las úlceras por presion y la supuración.
- Interrupción del flujo sanguíneo (reestenosis). Cierta evidencia sugiere que la administración de la L-arginina durante el implante de un stent seguido por la ingesta de suplementos de L-arginina durante dos semanas después del implante de stent no reduce el riesgo de sufrir de reestenosis. Sin embargo, otra evidencia sugiere que la administración de L-arginina en el área donde se implantó el stent podría reducir el engrosamiento de las paredes arteriales.
- Transplante de riñón. Es contradictoria la evidencia sobre la efectividad de la L-arginina en personas con trasplante de riñón. La investigación preliminar sugiere que la administración de L-arginina por vía intravenosa (VI) no mejora la función renal. Sin embargo, otra evidencia sugiere que la L-arginina no mejora la función renal. Estos resultados contradictorios podrían deberse a otros factores relacionados con el trasplante.
- Infecciones respiratorias. La investigación preliminar sugiere que la ingesta de L-arginina durante 60 días previene la recurrencia de las infecciones respiratorias en niños.
- Anemia drepanocítica. La investigación preliminar sugiere que la ingesta de L-arginine durante cinco días podría ser beneficiosa en personas con anemia drepanocítica e hipertensión arterial pulmonar.
- Estrés. Cierta investigación preliminar sugiere que la ingesta de una combinación de L-lisina y L-arginina durante un máximo de 10 días reduce el estrés y la ansiedad en personas sanas y en aquellas propensas a sufrir de estrés.
- Prevención del resfrío común.
- Problemas sexuales femeninos.
P Se necesita más evidencia para poder aprobar la L-arginina para estos usos.

T ¿Cómo funciona?
P La L-arginina es convertida en el cuerpo en una sustancia química llamada óxido nítrico. El óxido nítrico hace que los vasos sanguíneos se dilaten y así mejora el flujo sanguíneo. La L-arginina además estimula la liberación de la hormona del crecimiento, de la insulina y de otras sustancias en el cuerpo.

T ¿Hay preocupación por la seguridad de su uso?
P L-arginine is POSIBLEMENTE SEGURA en la mayoría de los pacientes cuando se la ingiere de manera apropiada, o se la administra como inyección o se la aplica en la piel por un corto tiempo. Puede producir algunos efectos secundarios tales como dolor abdominal, hinchazón, diarrea, gota, anormalidades de la sangre, alergias, inflamación de las vías respiratorias, empeoramiento del asma y baja presión arterial.
t Advertencias y precauciones especiales:
P Embarazo y lactancia: La L-arginina es POSIBLEMENTE SEGURA cuando se la ingiere de manera apropiada y por un corto plazo durante el embarazo. No se tiene suficiente información sobre el uso a largo plazo durante el embarazo y la lactancia. Sea precavida y evite su uso.
P Niños: La L-arginina es POSIBLEMENTE SEGURA cuando se usa por vía oral en infantes prematuros. Sin embargo, la L-arginina NO ES POSIBLEMENTE SEGURO cuando se lo usa en altas dosis. Las dosis muy altas pueden causar efectos secundarios graves incluidos muerte en niños.
P Alergia o asma: La L-arginina puede producir una respuesta alérgica o empeorar la hinchazón de las vías respiratorias. Si usted decide tomar L-arginina, úsela con cuidado.
P Cirrosis: La L-arginina debería usarse con precaución en personas con cirrosis.
P Carencia de carencia de guanidinoacetato metiltransferasa: Las personas con una condición hereditaria no pueden convertir la arginina y otros químicos Similares en creatinina. Para prevenir complicaciones asociados con esta condición, estas personas no deberían ingerir arginina.
P Herpes: Hay preocupación de que la L-arginina podría empeorar el herpes. Hay algunas pruebas que indican que la presencia de L-arginina es necesaria para que el virus del herpes se multiplique.
P Presión arterial alta: La L-arginina podría bajar la presión arterial. Esto podría ser un problema si usted ya tiene la presión baja.
P Reciente ataque al corazón: Hay preocupación que la L-arginina podría aumentar el riesgo de muerte después de un ataque al corazón, especialmente en las personas de edad avanzada. Si usted ha tenido un ataque al corazón recientemente, no tome L-arginina.
P Enfermedad renal: La arginina puede causar complicaciones fatales en personas con enfermedad renal.
P Cirugía: La L-arginina podría afectar la presión arterial. Hay preocupación de que podría interferir con el control de la presión arterial durante y después de una cirugía. Deje de tomar L-arginina por lo menos 2 semanas antes de someterse a una cirugía.

T ¿Existen interacciones con medicamentos?
P Serias
P No tome esta combinación
P Medicamentos para la presión arterial alta
P La L-arginina parece disminuir la presión arterial. El tomar L-arginina junto con medicamentos para la presión arterial alta podría hacer que su presión arterial baje demasiado.
P Algunos de los medicamentos para la presión arterial alta incluyen captoprila (Capoten), enalaprila (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipina (Norvasc), hidroclotiazida (HydroDiuril), furosemida (Lasix) y muchos otros.
P Moderadas
P Tenga cuidado con esta combinación
P Comprimidos para eliminar la retención de líquido (diuréticos ahorradores de potasio)
P La L-arginina también podría aumentar los niveles de potasio. Ciertos comprimidos para eliminar la retención de líquido podría aumentar los niveles de potasio en el cuerpo. En teoría, la ingesta de L-arginina junto con comprimidos para eliminar la retención de líquido podría causar un marcado aumento del nivel de potasio en el cuerpo. Ciertos comprimidos para eliminar la retención de líquido incluyen amilorida (Midamor), espironolactona (Aldactone) y triamterena (Dyrenium).
P Ciertos comprimidos para eliminar la retención de líquido y aumentar el nivel de potasio incluyen espironolactona (Aldactone), triamterena (Dyrenium) y la amilorida (Midamor).
P Medicamentos para la diabetes (Antidepresivos)
P La L-arginina parece disminuir los niveles de azúcar en la sangre en personas con diabetes tipo 2. Los medicamentos para la diabetes también se usan para disminuir los niveles de azúcar en la sangre. La ingesta de L-arginina junto con medicamentos para la diabetes podría causar una marcada disminución de los niveles de azúcar en la sangre. Controle minuciosamente sus niveles de azúcar en sangre. Podría necesitar modificar la dosis de su medicamento para la diabetes.
P Algunos medicamentos usados para la diabetes incluyen glimepirida (Amaryl), gliburida (Diabeta, Glynase, PresTab, Micronase), insulina, pioglitazona (Actos), rosiglitazona (Avandia) clorpropamida (Diabinese), glipizida (Glucotrol), tolbutamida (Orinase) y otros.
P Medicamentos para la presión arterial alta (bloqueadores de los receptores de angiotensina (BRA))
P La L-arginina parece disminuir la presión arterial. La ingesta de L-arginina junto con medicamentos para la presión arterial alta podría causar una marcada disminución de la presión arterial.
P Algunos de los BRA incluyen losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), el candesartan (Atacand), telmisartan (Micardis) y eprosartan (Teveten).
P Medicamentos para la presión arterial alta (inhibidores de la ECA)
P La L-arginina parece disminuir la presión arterial. La ingesta de L-arginina junto con medicamentos para la presión arterial alta, llamados inhibidores de la ECA, podría causar una marcada disminución de la presión arterial. Además, los inhibidores de la ECA pueden aumentar los niveles de potasio. La L-arginina también podría aumentar los niveles de potasio. La ingesta de L-arginina con los inhibidores de la ECA podría causar un marcado aumento de los niveles de potasio.
P Ciertos inhibidores de la ECA incluyen benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace) y trandolapril (Mavik).
P Medicamentos para la presión arterial alta (Isoproterenol)
P La L-arginina parece disminuir la presión arterial. El isoproterenol es un medicamento usado para disminuir la presión arterial. La ingesta de L-arginina junto con isoproterenol podría causar una marcada disminución de la presión arterial.
P Medicamentos que aumentan el flujo de sangre al corazón (Nitratos)
P La L-arginina aumenta el flujo de sangre El tomar L-arginina junto con medicamentos que también aumentan el flujo de sangre al corazón podría aumentar las probabilidades de mareos.
P Algunos de los medicamentos que aumentan el flujo de sangre al corazón incluyen nitroglicerina (Nitro-Bid, Nitro-Dur, Nitrostat) e isosorbida (Imdur, Isordil, Sorbitrate).
P Medicamentos que disminuyen la coagulación de la sangre (Anticoagulantes / Antiplaquetarios)
P La L-arginina parece disminuir la coagulación sanguínea. La ingesta de L-arginina junto con medicamentos que también disminuyen la coagulación podría reducir la probabilidad de sufrir hematomas y hemorragia.
P Algunos medicamentos que disminuyen la coagulación de la sangre incluyen aspirina, clopidogrel (Plavix), dalteparina (Fragmin), enoxaparina (Lovenox), heparina, ticlopidina (Ticlid), warfarina (Coumadin) entre otros.
P Sildenafil (Viagra)
P El sildenafil (Viagra) puede bajar la presión arterial. La L-arginina también puede bajar la presión arterial. El tomar sildenafil (Viagra) y L-arginina junto podría hacer que su presión arterial baje demasiado. Si la presión arterial es muy baja puede producir mareos y otros efectos secundarios.

T ¿Existen interacciones con hierbas y suplementos?
P Hierbas y suplementos que podrían disminuir la coagulación de la sangre
P La ingesta de L-arginina junto con otras hierbas que pueden disminuir la coagulación de la sangre podría aumentar el riesgo de hemorragia en algunas personas. Estas hierbas incluyen angélica, clavo de olor, danshen, ajo, ginkgo (Ginkgo biloba), Panax ginseng, trébol rojo, cúrcuma entre otros.
P Hierbas y suplementos que podrían disminuir la presión arterial
P La L-arginina parece disminuir la presión arterial. Si se lo ingiere junto con otras hierbas y suplementos que tienen el mismo efecto podría causar una marcada disminución de la presión arterial en ciertas personas. Algunos de estos productos incluyen andrographis, péptidos de caseína, uña de gato, coenzima Q10, aceite de pescado, L-arginina, licio, ortiga brava, teanina y otros.
P Hierbas y suplementos que podrían disminuir los niveles de azúcar en sangre
P La L-arginina parece disminuir los niveles de azúcar en la sangre. Consumirla junto con otras hierbas y suplementos que tienen el mismo efecto podría causar una marcada disminución de los niveles de azúcar en la sangre en ciertas personas. Algunos de estos productos incluyen garra del diablo, alholva, goma guar, Panax ginseng, ginseng siberiano y entre otros.
P Xylitol
P La L-arginina puede hacer que un órgano en el cuerpo llamado páncreas libere una hormona llamada glucagón. El glucagón viene al rescate cuando los niveles de azúcar en la sangre son muy bajos. El glucagón hace que el hígado convierta el azúcar que está almacenada en azúcar lista para usar y la libera al torrente sanguíneo. El usar xylitol junto con L-arginina puede impedir que la L-arginina estimule al páncreas para liberar glucagón.

T ¿Existen interacciones con alimentos?
P No se conoce ninguna interacción con alimentos.

T ¿Qué dosis se utiliza?
P Las siguientes dosis han sido estudiadas en investigaciones científicas:
P POR VIA ORAL:
- Para la insuficiencia cardíaca congestiva: las dosis van desde 6 a 20 gramos al día, en tres dosis divididas.
- Para el dolor de pecho asociado con la enfermedad arterial coronaria (angina de pecho): se usan 3 a 6 gramos tres veces al día por un período de hasta un año.
- Para prevenir la pérdida del efecto de la nitroglicerina que se usa para aliviar el dolor en las personas con dolor de pecho debido a la enfermedad arterial coronaria (angina de pecho): se usan 700 mg cuatro veces al día.
- Para la disfunción eréctil orgánica (ED): se usan 5 gramos al día. El tomar dosis menores podría no ser efectivo.
- Para prevenir la inflamación del tracto digestivo en los infantes prematuros: se agregan 261 mg/kg diarios a la alimentación oral por los primeros 28 días de vida.

T Otros nombres
P 2-Amino-5-guanidinopentanoic Acid, (2S)-2-Amino-5-{[amino (imino) methyl]amino}pentanoic Acid, (S)-2-Amino-5- Guanidinopentanoic Acid, Acide 2-Amino-5-Guanidinopentanoïque, Arg, Arginine, Arginine Ethyl Ester, Arginine Ethyl Ester Dihydrochloride, Arginine Ethyl Ester HCl, Arginine HCl, Arginine Hydrochloride, Di-Arginine Malate, Di-Arginine Orotate, Di-L-Arginine-L-Malate, Dl-Arginine, L-Arginine Ethyl Ester Dichloride, L-Arginine HCl, L-Arginine Hexanoate, L-Arginine Hydrochloride, L-Arginine Ketoisocaproic Acid, L-Arginine L-Pyroglutamate, L-Arginine Pyroglutamate, L-Arginine Taurinate, Malate de Di-Arginine, Orotate de Di-Arginine, R-Gene 10.

T Metodología
P Para saber más sobre cómo este artículo fue escrito, refiérase a la metodología de la Base exhaustiva de datos de medicamentos naturales.

T Referencias
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- Hughes, N., Mason, S., Jeffery, P., Welton, H., Tobin, M., O'Shea, C., and Browne, M. A comparative clinical study investigating the efficacy of a test dentifrice containing 8% strontium acetate and 1040 ppm sodium fluoride versus a marketed control dentifrice containing 8% arginine, calcium carbonate, and 1450 ppm sodium monofluorophosphate in reducing dentinal hypersensitivity. J Clin.Dent. 2010;21:49-55. View abstract.
- Koga, Y., Povalko, N., Nishioka, J., Katayama, K., Kakimoto, N., and Matsuishi, T. MELAS and L-arginine therapy: pathophysiology of stroke-like episodes. Ann.N.Y.Acad.Sci. 2010;1201:104-110. View abstract.
- Battaglia, C., Mancini, F., Battaglia, B., Facchinetti, F., Artini, P. G., and Venturoli, S. L-arginine plus drospirenone-ethinyl estradiol in the treatment of patients with PCOS: a prospective, placebo controlled, randomised, pilot study. Gynecol.Endocrinol. 2010;26:861-868. View abstract.
- Marik, P. E. and Zaloga, G. P. Immunonutrition in high-risk surgical patients: a systematic review and analysis of the literature. JPEN J Parenter.Enteral Nutr 2010;34:378-386. View abstract.
- Tan, B., Yin, Y., Liu, Z., Tang, W., Xu, H., Kong, X., Li, X., Yao, K., Gu, W., Smith, S. B., and Wu, G. Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle. J Nutr.Biochem. 2011;22:441-445. View abstract.
- Scavella, A., Leiva, L., Monjure, H., Zea, A. H., and Gardner, R. V. Effect of L-arginine supplementation on immune responsiveness in patients with sickle cell disease. Pediatr Blood Cancer 2010;55:318-323. View abstract.
- Sunderland, K. L., Greer, F., and Morales, J. VO2max and ventilatory threshold of trained cyclists are not affected by 28-day L-arginine supplementation. J Strength.Cond.Res 2011;25:833-837. View abstract.
- Guttman, H., Zimlichman, R., Boaz, M., Matas, Z., and Shargorodsky, M. Effect of Long-Term L-Arginine Supplementation on Arterial Compliance and Metabolic Parameters in Patients with Multiple Cardiovascular risk Factors: Randomized, Placebo-Controlled Study. J Cardiovasc.Pharmacol. 6-7-2010; View abstract.
- Ast, J., Jablecka, A., Bogdanski, P., Smolarek, I., Krauss, H., and Chmara, E. Evaluation of the antihypertensive effect of L-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring. Med.Sci.Monit. 2010;16:CR266-CR271. View abstract.
- Camic, C. L., Housh, T. J., Zuniga, J. M., Hendrix, R. C., Mielke, M., Johnson, G. O., and Schmidt, R. J. Effects of arginine-based supplements on the physical working capacity at the fatigue threshold. J Strength.Cond.Res 2010;24:1306-1312. View abstract.
- Srivastava, S. and Agarwal, A. Effect of anion channel blockers on L-arginine action in spermatozoa from asthenospermic men. Andrologia 2010;42:76-82. View abstract.
- Tripathi, P. and Misra, M. K. Therapeutic role of L-arginine on free radical scavenging system in ischemic heart diseases. Indian J Biochem.Biophys. 2009;46:498-502. View abstract.
- Carrier, M., Perrault, L. P., Fortier, A., Bouchard, D., and Pellerin, M. L-arginine supplemented nondiluted blood cardioplegia: a clinical trial. J Cardiovasc.Surg.(Torino) 2010;51:283-287. View abstract.
- Chen, S., Kim, W., Henning, S. M., Carpenter, C. L., and Li, Z. Arginine and antioxidant supplement on performance in elderly male cyclists: a randomized controlled trial. J Int.Soc Sports Nutr. 2010;7:13. View abstract.
- Olek, R. A., Ziemann, E., Grzywacz, T., Kujach, S., Luszczyk, M., Antosiewicz, J., and Laskowski, R. A single oral intake of arginine does not affect performance during repeated Wingate anaerobic test. J Sports Med.Phys.Fitness 2010;50:52-56. View abstract.
- Giuggioli, D., Colaci, M., Sebastiani, M., and Ferri, C. L-Arginine in pregnant scleroderma patients. Clin.Rheumatol. 2010;29:937-939. View abstract.
- Glueck, C. J., Munjal, J., Khan, A., Umar, M., and Wang, P. Endothelial nitric oxide synthase T-786C mutation, a reversible etiology of Prinzmetal's angina pectoris. Am J Cardiol 3-15-2010;105:792-796. View abstract.
- Doutreleau, S., Rouyer, O., Di, Marco P., Lonsdorfer, E., Richard, R., Piquard, F., and Geny, B. L-arginine supplementation improves exercise capacity after a heart transplant. Am J Clin.Nutr. 2010;91:1261-1267. View abstract.
- Ledda, A., Belcaro, G., Cesarone, M. R., Dugall, M., and Schonlau, F. Investigation of a complex plant extract for mild to moderate erectile dysfunction in a randomized, double-blind, placebo-controlled, parallel-arm study. BJU.Int. 2010;106:1030-1033. View abstract.
- Stechmiller, J. K. Understanding the role of nutrition and wound healing. Nutr.Clin.Pract. 2010;25:61-68. View abstract.
- Doley, J. Nutrition management of pressure ulcers. Nutr.Clin.Pract. 2010;25:50-60. View abstract.
- Jude, E. B., Dang, C., and Boulton, A. J. Effect of L-arginine on the microcirculation in the neuropathic diabetic foot in Type 2 diabetes mellitus: a double-blind, placebo-controlled study. Diabet.Med. 2010;27:113-116. View abstract.
- Huang, C. C., Lin, T. J., Lu, Y. F., Chen, C. C., Huang, C. Y., and Lin, W. T. Protective effects of L-arginine supplementation against exhaustive exercise-induced oxidative stress in young rat tissues. Chin J Physiol 10-31-2009;52:306-315. View abstract.
- Lagudis, S., Yamada, A. T., Vieira, M. L., Medeiros, C. C., Mansur, A. J., and Lage, S. G. The effect of dobutamine without and with L-arginine on arterial compliance in heart failure patients. Echocardiography. 2009;26:934-942. View abstract.
- Fontanive P, Saponati G, Iurato A, et al. Effects of L-arginine on the Minnesota Living with Heart Failure Questionnaire quality-of-life score in patients with chronic systolic heart failure. Med.Sci.Monit. 2009;15:CR606-11. View abstract.
- Sun, T., Zhou, W. B., Luo, X. P., Tang, Y. L., and Shi, H. M. Oral L-arginine supplementation in acute myocardial infarction therapy: a meta-analysis of randomized controlled trials. Clin.Cardiol 2009;32:649-652. View abstract.
- Ozbek, M., Erdogan, M., Karadeniz, M., Cetinkalp, S., Ozgen, A. G., Saygili, F., Yilmaz, C., and Tuzun, M. Evaluation of beta cell dysfunction by mixed meal tolerance test and oral L-arginine in patients with newly diagnosed type 2 diabetes mellitus. Exp.Clin.Endocrinol.Diabetes 2009;117:573-576. View abstract.
- Coeffier, M. and Dechelotte, P. Combined infusion of glutamine and arginine: does it make sense? Curr.Opin.Clin.Nutr.Metab Care 2010;13:70-74. View abstract.
- Cahill, N. E., Dhaliwal, R., Day, A. G., Jiang, X., and Heyland, D. K. Nutrition therapy in the critical care setting: what is "best achievable" practice? An international multicenter observational study. Crit Care Med. 2010;38:395-401. View abstract.
- Docimo, R., Montesani, L., Maturo, P., Costacurta, M., Bartolino, M., Zhang, Y. P., DeVizio, W., Delgado, E., Cummins, D., Dibart, S., and Mateo, L. R. Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark commercial desensitizing toothpaste containing 2% potassium ion: an eight-week clinical study in Rome, Italy. J Clin.Dent. 2009;20:137-143. View abstract.
- Nathoo, S., Delgado, E., Zhang, Y. P., DeVizio, W., Cummins, D., and Mateo, L. R. Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride relative to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride: a three-day clinical study in New Jersey, USA. J Clin.Dent. 2009;20:123-130. View abstract.
- Ayad, F., Ayad, N., Delgado, E., Zhang, Y. P., DeVizio, W., Cummins, D., and Mateo, L. R. Comparing the efficacy in providing instant relief of dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a benchmark desensitizing toothpaste containing 2% potassium ion and 1450 ppm fluoride, and to a control toothpaste with 1450 ppm fluoride: a three-day clinical study in Mississauga, Canada. J Clin.Dent. 2009;20:115-122. View abstract.
- Bescos, R., Gonzalez-Haro, C., Pujol, P., Drobnic, F., Alonso, E., Santolaria, M. L., Ruiz, O., Esteve, M., and Galilea, P. Effects of dietary L-arginine intake on cardiorespiratory and metabolic adaptation in athletes. Int.J Sport Nutr.Exerc.Metab 2009;19:355-365. View abstract.
- Ellinger, S. and Stehle, P. Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies. Curr.Opin.Clin.Nutr.Metab Care 2009;12:588-595. View abstract.
- Celik, J. B., Gezginc, K., Ozcelik, K., and Celik, C. The role of immunonutrition in gynecologic oncologic surgery. Eur.J Gynaecol.Oncol. 2009;30:418-421. View abstract.
- Hrncic, D., Rasic-Markovic, A., Krstic, D., Macut, D., Djuric, D., and Stanojlovic, O. The role of nitric oxide in homocysteine thiolactone-induced seizures in adult rats. Cell Mol.Neurobiol. 2010;30:219-231. View abstract.
- De Luis, D. A., Izaola, O., Cuellar, L., Terroba, M. C., Martin, T., and Aller, R. High dose of arginine enhanced enteral nutrition in postsurgical head and neck cancer patients. A randomized clinical trial. Eur.Rev.Med.Pharmacol Sci 2009;13:279-283. View abstract.
- Jahangir, E., Vita, J. A., Handy, D., Holbrook, M., Palmisano, J., Beal, R., Loscalzo, J., and Eberhardt, R. T. The effect of L-arginine and creatine on vascular function and homocysteine metabolism. Vasc.Med. 2009;14:239-248. View abstract.
- Okamoto, Y., Okano, K., Izuishi, K., Usuki, H., Wakabayashi, H., and Suzuki, Y. Attenuation of the systemic inflammatory response and infectious complications after gastrectomy with preoperative oral arginine and omega-3 fatty acids supplemented immunonutrition. World J Surg. 2009;33:1815-1821. View abstract.
- Gentile, V., Antonini, G., Antonella, Bertozzi M., Dinelli, N., Rizzo, C., Ashraf, Virmani M., and Koverech, A. Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes. Curr Med Res Opin. 2009;25:2223-2228. View abstract.
- Lucotti, P., Monti, L., Setola, E., La, Canna G., Castiglioni, A., Rossodivita, A., Pala, M. G., Formica, F., Paolini, G., Catapano, A. L., Bosi, E., Alfieri, O., and Piatti, P. Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass. Metabolism 2009;58:1270-1276. View abstract.
- Fan, X. Y., van den Berg, A., Snoek, M., van der Flier, L. G., Smids, B., Jansen, H. M., Liu, R. Y., and Lutter, R. Arginine deficiency augments inflammatory mediator production by airway epithelial cells in vitro. Respir.Res 2009;10:62. View abstract.
- Budoff, M. J., Ahmadi, N., Gul, K. M., Liu, S. T., Flores, F. R., Tiano, J., Takasu, J., Miller, E., and Tsimikas, S. Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial. Prev.Med. 2009;49(2-3):101-107. View abstract.
- Koppo, K., Taes, Y. E., Pottier, A., Boone, J., Bouckaert, J., and Derave, W. Dietary arginine supplementation speeds pulmonary VO2 kinetics during cycle exercise. Med.Sci.Sports Exerc. 2009;41:1626-1632. View abstract.
- Schulze, F., Glos, S., Petruschka, D., Altenburg, C., Maas, R., Benndorf, R., Schwedhelm, E., Beil, U., and Boger, R. H. L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides. Nutr.Res 2009;29:291-297. View abstract.
- Masha, A., Manieri, C., Dinatale, S., Bruno, G. A., Ghigo, E., and Martina, V. Prolonged treatment with N-acetylcysteine and L-arginine restores gonadal function in patients with polycystic ovary syndrome. J Endocrinol.Invest 2009;32:870-872. View abstract.
- Petrou, I., Heu, R., Stranick, M., Lavender, S., Zaidel, L., Cummins, D., Sullivan, R. J., Hsueh, C., and Gimzewski, J. K. A breakthrough therapy for dentin hypersensitivity: how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth. J Clin.Dent. 2009;20:23-31. View abstract.
- Mou, J., Fang, H., Jing, F., Wang, Q., Liu, Y., Zhu, H., Shang, L., Wang, X., and Xu, W. Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors. Bioorg.Med.Chem. 7-1-2009;17:4666-4673. View abstract.
- Malenfant, D., Catton, M., and Pope, J. E. The efficacy of complementary and alternative medicine in the treatment of Raynaud's phenomenon: a literature review and meta-analysis. Rheumatology.(Oxford) 2009;48:791-795. View abstract.
- Lee, J., Ryu, H., and Kowall, N. W. Motor neuronal protection by L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice. Biochem.Biophys.Res Commun. 7-10-2009;384:524-529. View abstract.
- Jovanovic, A., Gerrard, J., and Taylor, R. The second-meal phenomenon in type 2 diabetes. Diabetes Care 2009;32:1199-1201. View abstract.
- Winer, N., Branger, B., Azria, E., Tsatsaris, V., Philippe, H. J., Roze, J. C., Descamps, P., Boog, G., Cynober, L., and Darmaun, D. L-Arginine treatment for severe vascular fetal intrauterine growth restriction: a randomized double-bind controlled trial. Clin.Nutr. 2009;28:243-248. View abstract.
- Debats, I. B., Booi, D. I., Wehrens, K. M., Cleutjens, J., Deutz, N. E., van de Hogen, E., Bemelmans, M., and van der Hulst, R. R. Oral arginine supplementation and the effect on skin graft donor sites: a randomized clinical pilot study. J Burn Care Res 2009;30:417-426. View abstract.
- Kato, G. J., Wang, Z., Machado, R. F., Blackwelder, W. C., Taylor, J. G., and Hazen, S. L. Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death. Br J Haematol. 2009;145:506-513. View abstract.
- Amin, H. J., Soraisham, A. S., and Sauve, R. S. Neurodevelopmental outcomes of premature infants treated with l-arginine for prevention of necrotising enterocolitis. J Paediatr.Child Health 2009;45:219-223. View abstract.
- Weitzel, L. R., Mayles, W. J., Sandoval, P. A., and Wischmeyer, P. E. Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness. Curr.Opin.Anaesthesiol. 2009;22:177-183. View abstract.
- Boger, R. H., Sullivan, L. M., Schwedhelm, E., Wang, T. J., Maas, R., Benjamin, E. J., Schulze, F., Xanthakis, V., Benndorf, R. A., and Vasan, R. S. Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation 3-31-2009;119:1592-1600. View abstract.
- Little, J. A., Hauser, K. P., Martyr, S. E., Harris, A., Maric, I., Morris, C. R., Suh, J. H., Taylor, J., Castro, O., Machado, R., Kato, G., and Gladwin, M. T. Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy. Eur.J Haematol. 2009;82:315-321. View abstract.
- Takasaki, A., Tamura, H., Miwa, I., Taketani, T., Shimamura, K., and Sugino, N. Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertil.Steril. 2010;93:1851-1858. View abstract.
- Koga, Y. [L-arginine therapy on MELAS]. Rinsho Shinkeigaku 2008;48:1010-1012. View abstract.
- Baris, N., Erdogan, M., Sezer, E., Saygili, F., Mert, Ozgonul A., Turgan, N., and Ersoz, B. Alterations in L-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuria. Acta Diabetol. 2009;46:309-316. View abstract.
- Goligorsky, M. S. Endothelial nitric oxide synthase: from structure to function in one aspartic substitution. Kidney Int. 2009;75:255-257. View abstract.
- Stanislavov, R., Nikolova, V., and Rohdewald, P. Improvement of seminal parameters with Prelox: a randomized, double-blind, placebo-controlled, cross-over trial. Phytother.Res 2009;23:297-302. View abstract.
- Bracci, M., Tomasetti, M., Malavolta, M., Bonacucina, V., Mocchegiani, E., and Santarelli, L. L-arginine reduces mercury accumulation in thymus of mercury-exposed mice: role of nitric oxide synthase activity and metallothioneins. Ind.Health 2008;46:567-574. View abstract.
- Kato, G. J. and Gladwin, M. T. Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy. JAMA 12-10-2008;300:2638-2646. View abstract.
- Bai, Y., Sun, L., Yang, T., Sun, K., Chen, J., and Hui, R. Increase in fasting vascular endothelial function after short-term oral L-arginine is effective when baseline flow-mediated dilation is low: a meta-analysis of randomized controlled trials. Am J Clin.Nutr. 2009;89:77-84. View abstract.
- Gad, M. Z., El-Mesallamy, H. O., and Sanad, E. F. hsCRP, sICAM-1 and TAFI in hemodialysis patients: linking inflammation and hypofibrinolysis to cardiovascular events. Kidney Blood Press Res 2008;31:391-397. View abstract.
- Napoli, C., Farzati, B., Sica, V., Iannuzzi, E., Coppola, G., Silvestroni, A., Balestrieri, M. L., Florio, A., and Matarazzo, A. Beneficial effects of autologous bone marrow cell infusion and antioxidants/L-arginine in patients with chronic critical limb ischemia. Eur.J Cardiovasc.Prev.Rehabil. 2008;15:709-718. View abstract.
- Wu, G., Bazer, F. W., Davis, T. A., Kim, S. W., Li, P., Marc, Rhoads J., Carey, Satterfield M., Smith, S. B., Spencer, T. E., and Yin, Y. Arginine metabolism and nutrition in growth, health and disease. Amino.Acids 2009;37:153-168. View abstract.
- Heyman, H., Van De Looverbosch, D. E., Meijer, E. P., and Schols, J. M. Benefits of an oral nutritional supplement on pressure ulcer healing in long-term care residents. J Wound Care 2008;17:476-8, 480. View abstract.
- Fons, C., Sempere, A., Arias, A., Lopez-Sala, A., Poo, P., Pineda, M., Mas, A., Vilaseca, M. A., Salomons, G. S., Ribes, A., Artuch, R., and Campistol, J. Arginine supplementation in four patients with X-linked creatine transporter defect. J Inherit.Metab Dis 2008;31:724-728. View abstract.
- Moutaouakil, F., El, Otmani H., Fadel, H., Sefrioui, F., and Slassi, I. [l-arginine efficiency in MELAS syndrome. A case report]. Rev.Neurol.(Paris) 2009;165:482-485. View abstract.
- Settergren, M., Bohm, F., Malmstrom, R. E., Channon, K. M., and Pernow, J. L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease. Atherosclerosis 2009;204:73-78. View abstract.
- Childress, B., Stechmiller, J. K., and Schultz, G. S. Arginine metabolites in wound fluids from pressure ulcers: a pilot study. Biol.Res Nurs. 2008;10:87-92. View abstract.
- Binder, I., Rossbach, G., and van, Ophoven A. [The complexity of chronic pelvic pain exemplified by the condition currently called interstitial cystitis. Part 2: Treatment]. Aktuelle Urol. 2008;39:289-297. View abstract.
- Klek, S., Kulig, J., Sierzega, M., Szybinski, P., Szczepanek, K., Kubisz, A., Kowalczyk, T., Gach, T., Pach, R., and Szczepanik, A. M. The impact of immunostimulating nutrition on infectious complications after upper gastrointestinal surgery: a prospective, randomized, clinical trial. Ann.Surg. 2008;248:212-220. View abstract.
- Marik, P. E. and Zaloga, G. P. Immunonutrition in critically ill patients: a systematic review and analysis of the literature. Intensive Care Med. 2008;34:1980-1990. View abstract.
- Klek, S., Kulig, J., Sierzega, M., Szczepanek, K., Szybinski, P., Scislo, L., Walewska, E., Kubisz, A., and Szczepanik, A. M. Standard and immunomodulating enteral nutrition in patients after extended gastrointestinal surgery--a prospective, randomized, controlled clinical trial. Clin.Nutr 2008;27:504-512. View abstract.
- Chilosi, A., Leuzzi, V., Battini, R., Tosetti, M., Ferretti, G., Comparini, A., Casarano, M., Moretti, E., Alessandri, M. G., Bianchi, M. C., and Cioni, G. Treatment with L-arginine improves neuropsychological disorders in a child with creatine transporter defect. Neurocase. 2008;14:151-161. View abstract.
- Tuchman, M., Lee, B., Lichter-Konecki, U., Summar, M. L., Yudkoff, M., Cederbaum, S. D., Kerr, D. S., Diaz, G. A., Seashore, M. R., Lee, H. S., McCarter, R. J., Krischer, J. P., and Batshaw, M. L. Cross-sectional multicenter study of patients with urea cycle disorders in the United States. Mol.Genet.Metab 2008;94:397-402. View abstract.
- Chung, H. T., Choi, B. M., Kwon, Y. G., and Kim, Y. M. Interactive relations between nitric oxide (NO) and carbon monoxide (CO): heme oxygenase-1/CO pathway is a key modulator in NO-mediated antiapoptosis and anti-inflammation. Methods Enzymol. 2008;441:329-338. View abstract.
- Yeo, T. W., Lampah, D. A., Gitawati, R., Tjitra, E., Kenangalem, E., Granger, D. L., Weinberg, J. B., Lopansri, B. K., Price, R. N., Celermajer, D. S., Duffull, S. B., and Anstey, N. M. Safety profile of L-arginine infusion in moderately severe falciparum malaria. PLoS.One. 2008;3:e2347. View abstract.
- Fricke, O., Baecker, N., Heer, M., Tutlewski, B., and Schoenau, E. The effect of L-arginine administration on muscle force and power in postmenopausal women. Clin.Physiol Funct.Imaging 2008;28:307-311. View abstract.
- Acevedo, A. M., Montero, M., Rojas-Sanchez, F., Machado, C., Rivera, L. E., Wolff, M., and Kleinberg, I. Clinical evaluation of the ability of CaviStat in a mint confection to inhibit the development of dental caries in children. J Clin.Dent. 2008;19:1-8. View abstract.
- Binder, I. and van, Ophoven A. [The complexity of chronic pelvic pain exemplified by the condition currently called interstitial cystitis. Part 1: Background and basic principles]. Aktuelle Urol. 2008;39:205-214. View abstract.
- Casas-Rodera, P., Gomez-Candela, C., Benitez, S., Mateo, R., Armero, M., Castillo, R., and Culebras, J. M. Immunoenhanced enteral nutrition formulas in head and neck cancer surgery: a prospective, randomized clinical trial. Nutr.Hosp. 2008;23:105-110. View abstract.
- Huang, C. C., Tsai, S. C., and Lin, W. T. Potential ergogenic effects of L-arginine against oxidative and inflammatory stress induced by acute exercise in aging rats. Exp.Gerontol. 2008;43:571-577. View abstract.
- Mhanni, A. A., Chan, A., Collison, M., Seifert, B., Lehotay, D. C., Sokoro, A., Huynh, H. Q., and Greenberg, C. R. Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH) presenting with acute fulminant hepatic failure. J Pediatr Gastroenterol.Nutr. 2008;46:312-315. View abstract.
- Ruel, M., Beanlands, R. S., Lortie, M., Chan, V., Camack, N., deKemp, R. A., Suuronen, E. J., Rubens, F. D., DaSilva, J. N., Sellke, F. W., Stewart, D. J., and Mesana, T. G. Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse coronary artery disease: the Endothelial Modulation in Angiogenic Therapy randomized controlled trial. J Thorac.Cardiovasc.Surg. 2008;135:762-70, 770. View abstract.
- Hackett, A., Gillard, J., and Wilcken, B. n of 1 trial for an ornithine transcarbamylase deficiency carrier. Mol.Genet.Metab 2008;94:157-161. View abstract.
- Lauer, T., Kleinbongard, P., Rath, J., Schulz, R., Kelm, M., and Rassaf, T. L-arginine preferentially dilates stenotic segments of coronary arteries thereby increasing coronary flow. J Intern.Med. 2008;264:237-244. View abstract.
- Shao, A. and Hathcock, J. N. Risk assessment for the amino acids taurine, L-glutamine and L-arginine. Regul.Toxicol.Pharmacol 2008;50:376-399. View abstract.
- Berk, L., James, J., Schwartz, A., Hug, E., Mahadevan, A., Samuels, M., and Kachnic, L. A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122). Support.Care Cancer 2008;16:1179-1188. View abstract.
- Martina, V., Masha, A., Gigliardi, V. R., Brocato, L., Manzato, E., Berchio, A., Massarenti, P., Settanni, F., Della, Casa L., Bergamini, S., and Iannone, A. Long-term N-acetylcysteine and L-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes. Diabetes Care 2008;31:940-944. View abstract.
- Tarumoto, T., Imagawa, S., Kobayashi, M., Hirayama, A., Ozawa, K., and Nagasawa, T. L-arginine administration reverses anemia associated with renal disease. Int.J Hematol. 2007;86:126-129. View abstract.
- Sakurai, Y., Masui, T., Yoshida, I., Tonomura, S., Shoji, M., Nakamura, Y., Isogaki, J., Uyama, I., Komori, Y., and Ochiai, M. Randomized clinical trial of the effects of perioperative use of immune-enhancing enteral formula on metabolic and immunological status in patients undergoing esophagectomy. World J Surg. 2007;31:2150-2157. View abstract.
- Giger, U., Buchler, M., Farhadi, J., Berger, D., Husler, J., Schneider, H., Krahenbuhl, S., and Krahenbuhl, L. Preoperative immunonutrition suppresses perioperative inflammatory response in patients with major abdominal surgery-a randomized controlled pilot study. Ann.Surg.Oncol. 2007;14:2798-2806. View abstract.
- Wilson, A. M., Harada, R., Nair, N., Balasubramanian, N., and Cooke, J. P. L-arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation 7-10-2007;116:188-195. View abstract.
- Siasos, G., Tousoulis, D., Vlachopoulos, C., Antoniades, C., Stefanadi, E., Ioakeimidis, N., Andreou, I., Zisimos, K., Papavassiliou, A. G., and Stefanadis, C. Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals. Int.J Cardiol 6-6-2008;126:394-399. View abstract.
- Zhou, M. and Martindale, R. G. Arginine in the critical care setting. J Nutr. 2007;137(6 Suppl 2):1687S-1692S. View abstract.
- Smriga, M., Ando, T., Akutsu, M., Furukawa, Y., Miwa, K., and Morinaga, Y. Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans. Biomed.Res 2007;28:85-90. View abstract.
- Matsumoto, K., Mizuno, M., Mizuno, T., Dilling-Hansen, B., Lahoz, A., Bertelsen, V., Munster, H., Jordening, H., Hamada, K., and Doi, T. Branched-chain amino acids and arginine supplementation attenuates skeletal muscle proteolysis induced by moderate exercise in young individuals. Int.J Sports Med. 2007;28:531-538. View abstract.
- Tepaske, R., te, Velthuis H., Oudemans-van Straaten, H. M., Bossuyt, P. M., Schultz, M. J., Eijsman, L., and Vroom, M. Glycine does not add to the beneficial effects of perioperative oral immune-enhancing nutrition supplements in high-risk cardiac surgery patients. JPEN J Parenter.Enteral Nutr 2007;31:173-180. View abstract.
- Helminen, H., Raitanen, M., and Kellosalo, J. Immunonutrition in elective gastrointestinal surgery patients. Scand.J Surg. 2007;96:46-50. View abstract.
- Facchinetti, F., Saade, G. R., Neri, I., Pizzi, C., Longo, M., and Volpe, A. L-arginine supplementation in patients with gestational hypertension: a pilot study. Hypertens.Pregnancy. 2007;26:121-130. View abstract.
- Zheng, Y., Li, F., Qi, B., Luo, B., Sun, H., Liu, S., and Wu, X. Application of perioperative immunonutrition for gastrointestinal surgery: a meta-analysis of randomized controlled trials. Asia Pac.J Clin.Nutr. 2007;16 Suppl 1:253-257. View abstract.
- Finco, C., Magnanini, P., Sarzo, G., Vecchiato, M., Luongo, B., Savastano, S., Bortoliero, M., Barison, P., and Merigliano, S. Prospective randomized study on perioperative enteral immunonutrition in laparoscopic colorectal surgery. Surg.Endosc. 2007;21:1175-1179. View abstract.
- McConell, G. K. Effects of L-arginine supplementation on exercise metabolism. Curr.Opin.Clin.Nutr.Metab Care 2007;10:46-51. View abstract.
- Yan, H., Peng, X., Huang, Y., Zhao, M., Li, F., and Wang, P. Effects of early enteral arginine supplementation on resuscitation of severe burn patients. Burns 2007;33:179-184. View abstract.
- Savoye, G., Jemaa, Y., Mosni, G., Savoye-Collet, C., Morcamp, P., Dechelotte, P., Bouin, M., Denis, P., and Ducrotte, P. Effects of intragastric L-arginine administration on proximal stomach tone under basal conditions and after an intragastric diet. Dig.Dis Sci. 2006;51:2147-2153. View abstract.
- De Luis, D. A., Izaola, O., Cuellar, L., Terroba, M. C., Martin, T., and Aller, R. Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients. Eur.J Clin.Nutr 2007;61:200-204. View abstract.
- Rytlewski, K., Olszanecki, R., Lauterbach, R., Grzyb, A., and Basta, A. Effects of oral L-arginine on the foetal condition and neonatal outcome in preeclampsia: a preliminary report. Basic Clin.Pharmacol.Toxicol. 2006;99:146-152. View abstract.
- Wachtler, P., Axel, Hilger R., Konig, W., Bauer, K. H., Kemen, M., and Koller, M. Influence of a pre-operative enteral supplement on functional activities of peripheral leukocytes from patients with major surgery. Clin.Nutr 1995;14:275-282. View abstract.
- Xu, J., Zhong, Y., Jing, D., and Wu, Z. Preoperative enteral immunonutrition improves postoperative outcome in patients with gastrointestinal cancer. World J Surg. 2006;30:1284-1289. View abstract.
- Marin, V. B., Rodriguez-Osiac, L., Schlessinger, L., Villegas, J., Lopez, M., and Castillo-Duran, C. Controlled study of enteral arginine supplementation in burned children: impact on immunologic and metabolic status. Nutrition 2006;22(7-8):705-712. View abstract.
- Lobo, D. N., Williams, R. N., Welch, N. T., Aloysius, M. M., Nunes, Q. M., Padmanabhan, J., Crowe, J. R., Iftikhar, S. Y., Parsons, S. L., Neal, K. R., Allison, S. P., and Rowlands, B. J. Early postoperative jejunostomy feeding with an immune modulating diet in patients undergoing resectional surgery for upper gastrointestinal cancer: a prospective, randomized, controlled, double-blind study. Clin.Nutr 2006;25:716-726. View abstract.
- Lucotti, P., Setola, E., Monti, L. D., Galluccio, E., Costa, S., Sandoli, E. P., Fermo, I., Rabaiotti, G., Gatti, R., and Piatti, P. Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. Am J Physiol Endocrinol.Metab 2006;291:E906-E912. View abstract.
- Koga, Y., Akita, Y., Junko, N., Yatsuga, S., Povalko, N., Fukiyama, R., Ishii, M., and Matsuishi, T. Endothelial dysfunction in MELAS improved by l-arginine supplementation. Neurology 6-13-2006;66:1766-1769. View abstract.
- Schlaich, M. P., Oehmer, S., Schneider, M. P., Delles, C., Schmidt, B. M., and Schmieder, R. E. Effects of nitric oxide synthase inhibition and L-arginine on renal haemodynamics in young patients at high cardiovascular risk. Atherosclerosis 2007;192:155-160. View abstract.
- Neri, I., Jasonni, V. M., Gori, G. F., Blasi, I., and Facchinetti, F. Effect of L-arginine on blood pressure in pregnancy-induced hypertension: a randomized placebo-controlled trial. J Matern.Fetal Neonatal Med. 2006;19:277-281. View abstract.
- Hladunewich, M. A., Derby, G. C., Lafayette, R. A., Blouch, K. L., Druzin, M. L., and Myers, B. D. Effect of L-arginine therapy on the glomerular injury of preeclampsia: a randomized controlled trial. Obstet.Gynecol. 2006;107:886-895. View abstract.
- Colagrande, L., Formica, F., Porta, F., Martino, A., Sangalli, F., Avalli, L., and Paolini, G. Reduced cytokines release and myocardial damage in coronary artery bypass patients due to L-arginine cardioplegia supplementation. Ann.Thorac.Surg. 2006;81:1256-1261. View abstract.
- Oka, R. K., Szuba, A., Giacomini, J. C., and Cooke, J. P. A pilot study of L-arginine supplementation on functional capacity in peripheral arterial disease. Vasc.Med. 2005;10:265-274. View abstract.
- Mansoor, J. K., Morrissey, B. M., Walby, W. F., Yoneda, K. Y., Juarez, M., Kajekar, R., Severinghaus, J. W., Eldridge, M. W., and Schelegle, E. S. L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4,342 m. High Alt.Med.Biol. 2005;6:289-300. View abstract.
- Colagrande, L., Formica, F., Porta, F., Brustia, M., Avalli, L., Sangalli, F., Muratore, M., and Paolini, G. L-arginine effects on myocardial stress in cardiac surgery: preliminary results. Ital Heart J 2005;6:904-910. View abstract.
- Desneves, K. J., Todorovic, B. E., Cassar, A., and Crowe, T. C. Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial. Clin.Nutr. 2005;24:979-987. View abstract.
- Yin, W. H., Chen, J. W., Tsai, C., Chiang, M. C., Young, M. S., and Lin, S. J. L-arginine improves endothelial function and reduces LDL oxidation in patients with stable coronary artery disease. Clin.Nutr. 2005;24:988-997. View abstract.
- Parnell, M. M., Holst, D. P., and Kaye, D. M. Augmentation of endothelial function following exercise training is associated with increased L-arginine transport in human heart failure. Clin.Sci.(Lond) 2005;109:523-530. View abstract.
- Jezova, D., Makatsori, A., Smriga, M., Morinaga, Y., and Duncko, R. Subchronic treatment with amino acid mixture of L-lysine and L-arginine modifies neuroendocrine activation during psychosocial stress in subjects with high trait anxiety. Nutr.Neurosci. 2005;8:155-160. View abstract.
- Garhofer, G., Resch, H., Lung, S., Weigert, G., and Schmetterer, L. Intravenous administration of L-arginine increases retinal and choroidal blood flow. Am J Ophthalmol. 2005;140:69-76. View abstract.
- Stechmiller, J. K., Langkamp-Henken, B., Childress, B., Herrlinger-Garcia, K. A., Hudgens, J., Tian, L., Percival, S. S., and Steele, R. Arginine supplementation does not enhance serum nitric oxide levels in elderly nursing home residents with pressure ulcers. Biol.Res Nurs. 2005;6:289-299. View abstract.
- Gosselink, M. P., Darby, M., Zimmerman, D. D., Gruss, H. J., and Schouten, W. R. Treatment of chronic anal fissure by application of L-arginine gel: a phase II study in 15 patients. Dis Colon Rectum 2005;48:832-837. View abstract.
- Baecker, N., Boese, A., Schoenau, E., Gerzer, R., and Heer, M. L-arginine, the natural precursor of NO, is not effective for preventing bone loss in postmenopausal women. J Bone Miner.Res 2005;20:471-479. View abstract.
- Koga, Y., Akita, Y., Nishioka, J., Yatsuga, S., Povalko, N., Tanabe, Y., Fujimoto, S., and Matsuishi, T. L-arginine improves the symptoms of strokelike episodes in MELAS. Neurology 2-22-2005;64:710-712. View abstract.
- Farreras, N., Artigas, V., Cardona, D., Rius, X., Trias, M., and Gonzalez, J. A. Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer. Clin.Nutr 2005;24:55-65. View abstract.
- West, S. G., Likos-Krick, A., Brown, P., and Mariotti, F. Oral L-arginine improves hemodynamic responses to stress and reduces plasma homocysteine in hypercholesterolemic men. J Nutr. 2005;135:212-217. View abstract.
- Tsuei, B. J., Bernard, A. C., Barksdale, A. R., Rockich, A. K., Meier, C. F., and Kearney, P. A. Supplemental enteral arginine is metabolized to ornithine in injured patients. J Surg.Res 2005;123:17-24. View abstract.
- Grasemann, H., Grasemann, C., Kurtz, F., Tietze-Schillings, G., Vester, U., and Ratjen, F. Oral L-arginine supplementation in cystic fibrosis patients: a placebo-controlled study. Eur.Respir.J 2005;25:62-68. View abstract.
- Rytlewski, K., Olszanecki, R., Korbut, R., and Zdebski, Z. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur.J Clin.Invest 2005;35:32-37. View abstract.
- Xiao, X. M. and Li, L. P. L-Arginine treatment for asymmetric fetal growth restriction. Int.J Gynaecol.Obstet. 2005;88:15-18. View abstract.
- Kernohan, A. F., McIntyre, M., Hughes, D. M., Tam, S. W., Worcel, M., and Reid, J. L. An oral yohimbine/L-arginine combination (NMI 861) for the treatment of male erectile dysfunction: a pharmacokinetic, pharmacodynamic and interaction study with intravenous nitroglycerine in healthy male subjects. Br J Clin.Pharmacol. 2005;59:85-93. View abstract.
- Neri, I., Blasi, I., and Facchinetti, F. Effects of acute L-arginine infusion on non-stress test in hypertensive pregnant women. J Matern.Fetal Neonatal Med. 2004;16:23-26. View abstract.
- Schlaich, M. P., Ahlers, B. A., Parnell, M. M., and Kaye, D. M. beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine. J Hypertens. 2004;22:1917-1925. View abstract.
- Kiziltepe, U., Tunctan, B., Eyileten, Z. B., Sirlak, M., Arikbuku, M., Tasoz, R., Uysalel, A., and Ozyurda, U. Efficiency of L-arginine enriched cardioplegia and non-cardioplegic reperfusion in ischemic hearts. Int.J Cardiol 2004;97:93-100. View abstract.
- Sieroszewski, P., Suzin, J., and Karowicz-Bilinska, A. Ultrasound evaluation of intrauterine growth restriction therapy by a nitric oxide donor (L-arginine). J Matern.Fetal Neonatal Med. 2004;15:363-366. View abstract.
- Jiang, X. H., Li, N., Zhu, W. M., Wu, G. H., Quan, Z. W., and Li, J. S. Effects of postoperative immune-enhancing enteral nutrition on the immune system, inflammatory responses, and clinical outcome. Chin Med.J (Engl.) 2004;117:835-839. View abstract.
- De Luis, D. A., Izaola, O., Cuellar, L., Terroba, M. C., and Aller, R. Randomized clinical trial with an enteral arginine-enhanced formula in early postsurgical head and neck cancer patients. Eur.J Clin.Nutr 2004;58:1505-1508. View abstract.
- George, J., Shmuel, S. B., Roth, A., Herz, I., Izraelov, S., Deutsch, V., Keren, G., and Miller, H. L-arginine attenuates lymphocyte activation and anti-oxidized LDL antibody levels in patients undergoing angioplasty. Atherosclerosis 2004;174:323-327. View abstract.
- Dudek, D., Legutko, J., Heba, G., Bartus, S., Partyka, L., Huk, I., Dembinska-Kiec, A., Kaluza, G. L., and Dubiel, J. S. L-arginine supplementation does not inhibit neointimal formation after coronary stenting in human beings: an intravascular ultrasound study. Am Heart J 2004;147:E12. View abstract.
- Palloshi, A., Fragasso, G., Piatti, P., Monti, L. D., Setola, E., Valsecchi, G., Galluccio, E., Chierchia, S. L., and Margonato, A. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries. Am J Cardiol 4-1-2004;93:933-935. View abstract.
- Bode-Boger, S. M., Muke, J., Surdacki, A., Brabant, G., Boger, R. H., and Frolich, J. C. Oral L-arginine improves endothelial function in healthy individuals older than 70 years. Vasc.Med. 2003;8:77-81. View abstract.
- Park, K. G., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O., and Garlick, P. J. Stimulation of human breast cancers by dietary L-arginine. Clin.Sci.(Lond) 1992;82:413-417. View abstract.
- Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724. View abstract.
- Jiang, Z. M., Gu, Z. Y., Chen, F. L., Wang, X. R., Li, Z. J., Xu, Y., and Li, R. [The role of immune enhanced enteral nutrition on plasma amino acid, gut permeability and clinical outcome (a randomized, double blind, controlled, multi-center clinical trail with 120 cases)]. Zhongguo Yi.Xue.Ke.Xue.Yuan Xue.Bao. 2001;23:515-518. View abstract.
- Houwing, R. H., Rozendaal, M., Wouters-Wesseling, W., Beulens, J. W., Buskens, E., and Haalboom, J. R. A randomised, double-blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip-fracture patients. Clin.Nutr. 2003;22:401-405. View abstract.
- McGovern, M. M., Wasserstein, M. P., Aron, A., and Perrine, S. P. Biochemical effect of intravenous arginine butyrate in X-linked adrenoleukodystrophy. J Pediatr 2003;142:709-713. View abstract.
- Dallinger, S., Sieder, A., Strametz, J., Bayerle-Eder, M., Wolzt, M., and Schmetterer, L. Vasodilator effects of L-arginine are stereospecific and augmented by insulin in humans. Am J Physiol Endocrinol.Metab 2003;284:E1106-E1111. View abstract.
- Abdelhamed, A. I., Reis, S. E., Sane, D. C., Brosnihan, K. B., Preli, R. B., and Herrington, D. M. No effect of an L-arginine-enriched medical food (HeartBars) on endothelial function and platelet aggregation in subjects with hypercholesterolemia. Am Heart J 2003;145:E15. View abstract.
- Sydow, K., Schwedhelm, E., Arakawa, N., Bode-Boger, S. M., Tsikas, D., Hornig, B., Frolich, J. C., and Boger, R. H. ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins. Cardiovasc.Res 2003;57:244-252. View abstract.
- Miller, H. I., Dascalu, A., Rassin, T. A., Wollman, Y., Chernichowsky, T., and Iaina, A. Effects of an acute dose of L-arginine during coronary angiography in patients with chronic renal failure: a randomized, parallel, double-blind clinical trial. Am J Nephrol. 2003;23:91-95. View abstract.
- Braga, M., Gianotti, L., Vignali, A., and Carlo, V. D. Preoperative oral arginine and n-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer. Surgery 2002;132:805-814. View abstract.
- Carey, P. E., Halliday, J., Snaar, J. E., Morris, P. G., and Taylor, R. Direct assessment of muscle glycogen storage after mixed meals in normal and type 2 diabetic subjects. Am J Physiol Endocrinol.Metab 2003;284:E688-E694. View abstract.
- De Luis, D. A., Aller, R., Izaola, O., Cuellar, L., and Terroba, M. C. Postsurgery enteral nutrition in head and neck cancer patients. Eur.J Clin.Nutr 2002;56:1126-1129. View abstract.
- Lekakis, J. P., Papathanassiou, S., Papaioannou, T. G., Papamichael, C. M., Zakopoulos, N., Kotsis, V., Dagre, A. G., Stamatelopoulos, K., Protogerou, A., and Stamatelopoulos, S. F. Oral L-arginine improves endothelial dysfunction in patients with essential hypertension. Int.J Cardiol 2002;86(2-3):317-323. View abstract.
- Song, J. X., Qing, S. H., Huang, X. C., and Qi, D. L. Effect of parenteral nutrition with L-arginine supplementation on postoperative immune function in patients with colorectal cancer. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2002;22:545-547. View abstract.
- Bennett-Richards, K. J., Kattenhorn, M., Donald, A. E., Oakley, G. R., Varghese, Z., Bruckdorfer, K. R., Deanfield, J. E., and Rees, L. Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure. Kidney Int. 2002;62:1372-1378. View abstract.
- Schaefer, A., Piquard, F., Geny, B., Doutreleau, S., Lampert, E., Mettauer, B., and Lonsdorfer, J. L-arginine reduces exercise-induced increase in plasma lactate and ammonia. Int.J Sports Med. 2002;23:403-407. View abstract.
- Cassone, Faldetta M., Laurenti, O., Desideri, G., Bravi, M. C., De, Luca O., Marinucci, M. C., De, Mattia G., and Ferri, C. L-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in Type II diabetic patients. Diabetologia 2002;45:1120-1127. View abstract.
- van den Meiracker, A. H., van der Linde, N. A., Broere, A., Derkx, F. H., and Boomsma, F. Effects of L-arginine and L-NAME on the renal function in hypertensive and normotensive subjects. Nephron 2002;91:444-451. View abstract.
- Cen, Y., Luo, X. S., and Liu, X. X. [Effect of L-arginine supplementation on partial-thickness burned patients]. Zhongguo Xiu.Fu Chong.Jian.Wai Ke.Za Zhi. 1999;13:227-231. View abstract.
- Gianotti, L., Braga, M., Nespoli, L., Radaelli, G., Beneduce, A., and Di, Carlo, V. A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology 2002;122:1763-1770. View abstract.
- Kimber, J., Watson, L., and Mathias, C. J. Cardiovascular and neurohormonal responses to i. v. l-arginine in two groups with primary autonomic failure. J Neurol. 2001;248:1036-1041. View abstract.
- Schramm, L., La, M., Heidbreder, E., Hecker, M., Beckman, J. S., Lopau, K., Zimmermann, J., Rendl, J., Reiners, C., Winderl, S., Wanner, C., and Schmidt, H. H. L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation. Kidney Int. 2002;61:1423-1432. View abstract.
- Carrier, M., Pellerin, M., Perrault, L. P., Bouchard, D., Page, P., Searle, N., and Lavoie, J. Cardioplegic arrest with L-arginine improves myocardial protection: results of a prospective randomized clinical trial. Ann.Thorac.Surg. 2002;73:837-841. View abstract.
- Kawano, H., Motoyama, T., Hirai, N., Kugiyama, K., Yasue, H., and Ogawa, H. Endothelial dysfunction in hypercholesterolemia is improved by L-arginine administration: possible role of oxidative stress. Atherosclerosis 2002;161:375-380. View abstract.
- Suzuki, T., Hayase, M., Hibi, K., Hosokawa, H., Yokoya, K., Fitzgerald, P. J., Yock, P. G., Cooke, J. P., Suzuki, T., and Yeung, A. C. Effect of local delivery of L-arginine on in-stent restenosis in humans. Am J Cardiol 2-15-2002;89:363-367. View abstract.
- Braga, M., Gianotti, L., Nespoli, L., Radaelli, G., and Di, Carlo, V. Nutritional approach in malnourished surgical patients: a prospective randomized study. Arch.Surg. 2002;137:174-180. View abstract.
- Bello, E., Caramelo, C., Martell, N., Alcazar, J. M., Gonzalez, J., Lopez, M. D., Ruilope, L. M., Gonzalez, F. R., Rovira, A. M., Gazapo, R., Soldevilla, M. J., and Casado, S. Impairment of renal vasodilation with l-arginine is related to more severe disease in untreated hypertensive patients. Hypertension 2001;38:907-912. View abstract.
- Mantovani, F., Patelli, E., Colombo, F., Pozzoni, F., Confalonieri, S., and Pisani, E. [Erectile dysfunction after non-nerve sparing radical pelvic surgery. Therapeutical experience with sildenafil and L-arginine evaluated by Buckling test]. Minerva Med. 2001;92:285-287. View abstract.
- Zhang, X. Z., Ardissino, G., Ghio, L., Tirelli, A. S., Dacco, V., Colombo, D., Pace, E., Testa, S., and Claris-Appiani, A. L-arginine supplementation in young renal allograft recipients with chronic transplant dysfunction. Clin.Nephrol. 2001;55:453-459. View abstract.
- Piatti, P. M., Monti, L. D., Valsecchi, G., Magni, F., Setola, E., Marchesi, F., Galli-Kienle, M., Pozza, G., and Alberti, K. G. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care 2001;24:875-880. View abstract.
- Angdin, M., Settergren, G., Liska, J., and Astudillo, R. No effect of L-arginine supplementation on pulmonary endothelial dysfunction after cardiopulmonary bypass. Acta Anaesthesiol.Scand. 2001;45:441-448. View abstract.
- Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir.Crit Care Med. 2001;163:887-891. View abstract.
- van Bokhorst-De Van Der Schueren, MA, Quak, J. J., von Blomberg-van der Flier BM, Kuik, D. J., Langendoen, S. I., Snow, G. B., Green, C. J., and van Leeuwen, P. A. Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am.J Clin.Nutr 2001;73:323-332. View abstract.
- Morris, C. R., Kuypers, F. A., Larkin, S., Sweeters, N., Simon, J., Vichinsky, E. P., and Styles, L. A. Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease. Br J Haematol. 2000;111:498-500. View abstract.
- Riso, S., Aluffi, P., Brugnani, M., Farinetti, F., Pia, F., and D'Andrea, F. Postoperative enteral immunonutrition in head and neck cancer patients. Clin.Nutr 2000;19:407-412. View abstract.
- Bednarz, B., Wolk, R., Chamiec, T., Herbaczynska-Cedro, K., Winek, D., and Ceremuzynski, L. Effects of oral L-arginine supplementation on exercise-induced QT dispersion and exercise tolerance in stable angina pectoris. Int.J Cardiol 9-15-2000;75(2-3):205-210. View abstract.
- Gianotti, L., Braga, M., Gentilini, O., Balzano, G., Zerbi, A., and Di, Carlo, V. Artificial nutrition after pancreaticoduodenectomy. Pancreas 2000;21:344-351. View abstract.
- Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72:24-27. View abstract.
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