Glucose screening tests during pregnancy: MedlinePlus Medical Encyclopedia

P A glucose screening test is a routine test during pregnancy that checks a pregnant woman's blood glucose (sugar) level.
P Gestational diabetes is high blood sugar (diabetes) that starts or is found during pregnancy.

T How the Test is Performed
P TWO-STEP TESTING
P During the first step, you will have a glucose screening test:
- You DO NOT need to prepare or change your diet in any way.
- You will be asked to drink a liquid that contains glucose.
- Your blood will be drawn 1 hour after you drink the glucose solution to check your blood glucose level.
P If your blood glucose from the first step is too high, you will need to come back for a 3-hour glucose tolerance test. For this test:
- DO NOT eat or drink anything (other than sips of water) for 8 to 14 hours before your test. (You also cannot eat during the test.)
- You will be asked to drink a liquid that contains glucose, 100 grams (g) .
- You will have blood drawn before you drink the liquid, and again 3 more times every 60 minutes after you drink it. Each time, your blood glucose level will be checked.
- Allow at least 3 hours for this test.
P ONE-STEP TESTING
P You need to go to the lab one time for a 2-hour glucose tolerance test. For this test:
- DO NOT eat or drink anything (other than sips of water) for 8 to 14 hours before your test. (You also cannot eat during the test.)
- You will be asked to drink a liquid that contains glucose (75 g).
- You will have blood drawn before you drink the liquid, and again 2 more times every 60 minutes after you drink it. Each time, your blood glucose level will be checked.
- Allow at least 2 hours for this test.

T How to Prepare for the Test
P For either the two-step test or one-step test, eat your normal food in the days before your test. Ask your health care provider if any of the medicines you take can affect your test results.

T How the Test will Feel
P Most women DO NOT have side effects from the glucose tolerance test. Drinking the glucose solution is similar to drinking a very sweet soda. Some women may feel nauseated, sweaty, or lightheaded after they drink the glucose solution. Serious side effects from this test are very uncommon.

T Why the Test is Performed
P This test checks for gestational diabetes. Most pregnant women have a glucose screening test between 24 and 28 weeks of pregnancy. The test may be done earlier if you have a high glucose level in your urine during your routine prenatal visits, or if you have a high risk for diabetes.
P Women who have a low risk for diabetes may not have the screening test. To be low-risk, all of these statements must be true:
- You have never had a test that showed your blood glucose was higher than normal.
- Your ethnic group has a low risk for diabetes.
- You DO NOT have any first-degree relatives (parent, sibling, or child) with diabetes.
- You are younger than 25 years old and have a normal weight.
- You have not had any bad outcomes during an earlier pregnancy.

T Normal Results
P TWO-STEP TESTING
P Most of the time, a normal result for the glucose screening test is a blood sugar that is equal to or less than 140 mg/dL (7.8 mmol/L) 1 hour after drinking the glucose solution. A normal result means you DO NOT have gestational diabetes.
P Note: mg/dL means milligrams per deciliter and mmol/L means millimoles per liter. These are two ways to indicate how much glucose is in the blood.
P If your blood glucose is higher than 140 mg/dL (7.8 mmol/L), the next step is the oral glucose tolerance test. This test will show if you have gestational diabetes. Most women (about 2 out of 3) who take this test DO NOT have gestational diabetes.
P ONE-STEP TESTING
P If your glucose level is lower than the abnormal results described below, you do not have gestational diabetes.

T What Abnormal Results Mean
P TWO-STEP TESTING
P Abnormal blood values for a 3-hour 100-gram oral glucose tolerance test are:
- Fasting: greater than 95 mg/dL (5.3 mmol/L)
- 1 hour: greater than 180 mg/dL (10.0 mmol/L)
- 2 hour: greater than 155 mg/dL (8.6 mmol/L)
- 3 hour: greater than 140 mg/dL (7.8 mmol/L)
P ONE-STEP TESTING
P Abnormal blood values for a 2-hour 75-gram oral glucose tolerance test are:
- Fasting: greater than 92 mg/dL (5.1 mmol/L)
- 1 hour: greater than 180 mg/dL (10.0 mmol/L)
- 2 hour: greater than 153 mg/dL (8.5 mmol/L)
P If only one of your blood glucose results in the oral glucose tolerance test is higher than normal, your provider may simply suggest you change some of the foods you eat. Then, your provider may test you again after you have changed your diet.
P If more than one of your blood glucose results is higher than normal, you have gestational diabetes.

T Risks
P You may have some of the symptoms listed above under the heading titled "How the Test will Feel."
P Veins and arteries vary in size from one person to another, and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
P Other risks associated with having blood drawn are slight, but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)

T Alternative Names
P Oral glucose tolerance test - pregnancy; OGTT - pregnancy; Glucose challenge test - pregnancy; Gestational diabetes - glucose screening

T References
P American Diabetes Association. Standards of medical care in diabetes - 2016: 2. classification and diagnosis of diabetes. Diabetes Care. 2016:39;Suppl 1:S13-S22. PMID 26696680 www.ncbi.nlm.nih.gov/pubmed/26696680.
P Committee on Practice Bulletins--Obstetrics. Practice Bulletin No. 137: Gestational diabetes mellitus. Obstet Gynecol. 2013:122(2 Pt 1):406-416. PMID: 23969827 www.ncbi.nlm.nih.gov/pubmed/23969827.
P London MB, Catalano PM, Gabbe SG. Diabetes mellitus complicating pregnancy. In: Gabbe SG, Niebyl JR, Simpson JL, et al, eds. Obstetrics: Normal and Problem Pregnancies. 7th ed. Philadelphia, PA: Elsevier Saunders; 2017:chap 40.
P Metzger BE. Diabetes mellitus and pregnancy. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 45.

T Review Date 5/16/2016
P Updated by: Irina Burd, MD, PhD, Associate Professor of Gynecology and Obstetrics at Johns Hopkins University School of Medicine, Baltimore, MD. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team. Editorial update 9/30/2016.

