Estradiol Topical: MedlinePlus Drug Information

T IMPORTANT WARNING:
P Estradiol increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus [womb]). The longer you use estradiol, the greater the risk that you will develop endometrial cancer. If you have not had a hysterectomy (surgery to remove the uterus), you should be given another medication called a progestin to take with topical estradiol. This may decrease your risk of developing endometrial cancer but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using topical estradiol, tell your doctor if you have or have ever had cancer and if you have abnormal or unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with topical estradiol. Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment.
P In a large study, women who took estrogens (a group of medications that includes estradiol) by mouth with progestins had a higher risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand). Women who use topical estradiol alone or with progestins may also have a higher risk of developing these conditions. Tell your doctor if you smoke or use tobacco, if you have had a heart attack or a stroke in the past year and if you or anyone in your family has or has ever had blood clots or breast cancer. Also tell your doctor if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breast used to find breast cancer).
P The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are using topical estradiol: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision;double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; breast lumps or other breast changes; discharge from nipples; difficulty thinking clearly, remembering, or learning new things; or pain, tenderness, or redness in one leg.
P You can take steps to decrease the risk that you will develop a serious health problem while you are using topical estradiol. Do not use topical estradiol alone or with a progestin to prevent heart disease, heart attacks, or strokes. Use the lowest dose of topical estradiol that controls your symptoms and only use topical estradiol as long as needed. Talk to your doctor every 3-6 months to decide if you should use a lower dose of topical estradiol or should stop using the medication.
P You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history.
P Tell your doctor if you are having surgery or will be on bedrest. Your doctor may tell you to stop using topical estradiol 4-6 weeks before the surgery or bedrest to decrease the risk that you will develop blood clots.
P Talk to your doctor regularly about the risks and benefits of using topical estradiol.

T Why is this medication prescribed?
P Estradiol topical gel and emulsion (lotion type mixture) are used to treat and prevent hot flushes (hot flashes; sudden strong feelings of heat and sweating) in women who are experiencing menopause (change of life; the end of monthly menstrual periods). Estradiol topical gel is also used to treat vaginal dryness, itching, and burning in women who are experiencing menopause. However, women whose only bothersome symptoms are vaginal burning, itching, and dryness may benefit more from a medication that is applied topically to the vagina. Estradiol is in a class of medications called estrogen hormones. It works by replacing estrogen that is normally produced by the body.

T How should this medicine be used?
P Topical estradiol comes as a gel, a spray, and an emulsion to apply to the skin. It is usually applied once a day. Estradiol emulsion should be applied in the morning. Estradiol gel may be applied at any time of day, but should be applied at around the same time of day every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use topical estradiol exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
P If you are using estradiol gel, you should apply it in a thin layer to one arm, from the wrist to the shoulder. If you are using estradiol emulsion, you should apply it to both thighs and calves (lower legs). Do not apply estradiol gel or emulsion to your breasts. Be sure that the skin where you will apply topical estradiol is clean and completely dry, and is not red, irritated, or broken.
P If you take a bath or a shower or use a sauna, apply topical estradiol after you have finished bathing, showering or using the sauna and have dried your skin completely. If you plan to swim, allow as much time as possible between applying estradiol gel and swimming. Do not apply sunscreen shortly before, at the same time, or soon after you apply topical estradiol.
P Estradiol gel may catch fire. When you apply estradiol gel, do not smoke or go near a fire or open flame until the gel dries.
P Be careful not to get estradiol gel in your eyes. If you do get estradiol gel in your eyes, wash them with plenty of warm water right away. Call a doctor if your eyes become irritated.
P You should apply estradiol gel yourself. Do not let anyone else rub the gel onto your skin.
t To use estradiol gel, follow these steps:
- Before you use your first dose of estradiol gel, remove the large cover of the pump and fully press down the pump twice. Wash the gel that comes out down the sink or dispose of it safely so that it is out of the reach of children and pets. This primes the pump so that it will dispense the same amount of medication each time it is pressed. Do not repeat this step after the first time you use the pump.
- Hold the pump with one hand and cup your other hand below the nozzle of the pump. Press the pump firmly and fully to dispense one dose of gel onto your palm.
- Use your hand to spread the gel as thinly as possible over your entire arm. Try to cover the inside and outside of your arm from your wrist to your shoulder with the gel.
- Do not rub or massage the gel into your skin. Wait 5 minutes to allow the skin to dry before covering your arm with clothing.
- Cover the pump with the small and large protective caps.
- Wash your hands with soap and water.
t To use estradiol emulsion, follow these steps:
- Get two pouches of estradiol emulsion and sit in a comfortable position.
- Open one pouch of estradiol emulsion by cutting or tearing across the notches near the top of the pouch.
- Place the pouch flat on top of your left thigh with the open end facing your knee.
- Hold the closed end of the pouch with one hand and use the forefinger of your other hand to push all of the emulsion in the pouch onto your thigh.
- Use one or both hands to rub the emulsion into your entire thigh and calf for 3 minutes until completely absorbed.
- Rub any emulsion that is left on your hands onto your buttocks.
- Repeat steps 1-6 using a fresh pouch of estradiol emulsion and your right thigh so that you apply the contents of the second pouch to your right thigh and calf.
- Wait until the skin where you applied estradiol emulsion is completely dry and cover it with clothing.
- Wash your hands with soap and water.
P Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

T Other uses for this medicine
P This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

T What special precautions should I follow?
t Before using topical estradiol,
- tell your doctor and pharmacist if you are allergic to estradiol gel or emulsion, any other estrogen products, any other medications, or any of the ingredients in estradiol gel or emulsion. Ask your pharmacist for a list of the ingredients in estradiol gel or emulsion or if you are not sure if a medication you are allergic to contains estrogen.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements, you are taking or plan to take. Be sure to mention any of the following: antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral); carbamazepine (Carbatrol, Epitol, Tegretol); clarithromycin (Biaxin); erythromycin (E.E.S, Erythrocin); lovastatin (Altocor, Mevacor); medications for thyroid disease; phenobarbital; rifampin (Rifadin, Rimactane, in Rifamate); and ritonavir (Norvir, in Kaletra), Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had asthma; seizures; migraine headaches; endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body); uterine fibroids (growths in the uterus that are not cancer); yellowing of the skin or eyes, especially during pregnancy or while you were using an estrogen product; very high or very low levels of calcium in your blood; porphyria (condition in which abnormal substances build up in the blood and cause problems with the skin or nervous system) or gallbladder, thyroid, liver, pancreas, or kidney disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using topical estradiol, call your doctor.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Remember to allow some time between applying topical estradiol and applying sunscreen. Estradiol gel may make your skin sensitive to sunlight.
- you should know that topical estradiol may harm other people who touch the medication that is on your skin or in the container. It is most harmful to men and children. Do not let anyone else touch the skin where you applied topical estradiol for one hour after you apply the medication. If someone does touch topical estradiol, that person should wash his or her skin with soap and water as soon as possible.

T What special dietary instructions should I follow?
P Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.

T What should I do if I forget a dose?
P If you forget to apply a dose of estradiol gel but remember more than 12 hours before you are scheduled to apply your next dose, apply the missed dose right away. If you remember less than 12 hours before you are scheduled to apply your next dose, skip the missed dose and continue your regular dosing schedule the next day. Do not apply extra gel to make up for a missed dose.
P If you forget to apply estradiol emulsion in the morning, apply it as soon as you remember. Do not apply extra emulsion to make up for a missed dose and do not apply estradiol emulsion more than once each day.

T What side effects can this medication cause?
t Topical estradiol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache
- breast pain or tenderness
- nausea
- diarrhea
- constipation
- gas
- heartburn
- weight gain or loss
- mood changes
- depression
- nervousness
- sleepiness
- difficulty falling asleep or staying asleep
- changes in sexual desire
- back pain
- runny nose
- cough
- flu-like symptoms
- hair loss
- unwanted hair growth
- darkening of the skin on the face
- difficulty wearing contact lenses
- irritation or redness of the skin where you applied topical estradiol
- swelling, redness, burning, irritation, or itching of the vagina
- vaginal discharge
t Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
- bulging eyes
- yellowing of the skin or eyes
- itching
- loss of appetite
- fever
- joint pain
- stomach tenderness, pain, or swelling
- movements that are difficult to control
- hives
- rash or blisters on the skin
- swelling, of the eyes, face, lips, tongue, throat, hands, feet, ankles, or lower legs
- hoarseness
- wheezing
- difficulty breathing or swallowing
P Topical estradiol may increase your risk of developing cancer of the ovaries and gallbladder disease that may need to be treated with surgery. Talk to your doctor about the risks of using this medication.
P Topical estradiol may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
P If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

T What should I know about storage and disposal of this medication?
P Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not freeze topical estradiol. Keep estradiol gel away from open flame. Dispose of your estradiol gel pump after you have used 64 doses even if it is not completely empty.
P Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
P It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

T In case of emergency/overdose
P In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
t Symptoms of overdose may include:
- nausea
- vomiting
- vaginal bleeding

T What other information should I know?
P Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to topical estradiol.
P Before having any laboratory test, tell your doctor and the laboratory personnel that you are using topical estradiol.
P Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.
P It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

T Brand names
- Divigel®
- Elestrin®
- Estrasorb®
- EstroGel®
- Evamist®

T Other names
- Estrogen Replacement Therapy
- ERT

