Published September 18, 2019 | Version 1.0.1
Dataset Open

PsPM-DoxMem2: Pupil, SCR, ECG, EMG and respiration measurement in a classical pavlovian discriminant delay fear conditioning task, reminder under doxycycline/placebo, retention and re-learning

  • 1. University of Zurich, Zurich, Switzerland
  • 2. Psychiatrische Universitätsklinik Zürich, Zurich, Switzerland

Description

This dataset includes eyetracker, skin conductance response (SCR), electrocardiogram (ECG), respiration and electromyogram (EMG, only relevant for retention phase) measurements. Also included are CS and US information, keypress responses and keypress response times for 79 healthy participants (40 males and 39 females aged 24.8+/-4.9 years). Participants underwent a classical (Pavlovian) discriminant delay fear conditioning task with 1 CS- and 2 CS+ (50% reinforcement), were reminded of one CS+ one week later under either doxycycline or placebo, and were tested in a retention/extinction and re-learning task another week later. CS were isoluminant coloured triangles. US consisted of 0.5 s square electric pulses with 0.2 ms duration and 500 Hz frequency. SOA between the CS onset and US was 3.5 s. CS and US co-terminated. Before the fear conditioning task, participants completed several questionnaires. During the retention/extinction phase, an auditory startle probe (ST) and no US was delivered 3.5 s after CS onset via headphones (102 dB, 40 ms duration with 2 ms on- and offset ramp). In an immediately following re-learning phase, the ST was omitted and the CS reinforced with the same schedule as during acquisition. The ITI was randomly determined on each trial to be 7, 9, or 11 s.

 

Notes

See readme for further details. This work was supported by Hartmann Muller Foundation, by the Foundation for Research in Science and the Humanities at the University of Zurich (STWF 18-004), and by the University of Zurich's Clinical Research Priority Program for the CRPP "Synapse & Trauma". The Wellcome Centre for Human Neuroimaging is supported by core funding from the Wellcome Trust [091593/Z/10/Z].

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Additional details

Funding

Core support for the Wellcome Trust Centre for Neuroimaging 091593
Wellcome Trust