Published August 31, 2019 | Version v1
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FORMULATION AND EVALUATION OF BACLOFEN EXTENDED RELEASE TABLETS.

  • 1. Department of Pharmaceutics, Browns College of Pharmacy, Khammam, Telangana,India.

Description

The aim of the present study was to develop Extended release formulation of Baclofen to maintain constant therapeutic levels of the drug for over 12 hrs. Guar gum, sodium alginate and carbopol 940 were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e., 96.32% in 12 hours. It contains the sodium alginate as Extended release material. It followed Zero order release kinetics mechanism.

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