Published April 1, 2019
| Version v1
Dataset
Open
Molecular Forecaster Inc (MFI): USP5 Zf-UBD
Creators
- 1. University of Toronto; Structural Genomics Consortium
Description
Self-docking of ligands in USP5 zinc finger ubiquitin binding domain (Zf-UBD) co-crystal structures using the Forecaster FITTED docking platform is assessed and the ranking success of FITTED rigid protein docking vs. MATCHUP flexible protein docking on a library of experimentally tested compounds is investigated.
Notes
Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.
Files
1_MFI USP5.pdf
Files
(5.0 MB)
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