calc_total_clearance {httkgui}R Documentation

Calculate the total clearance.

Description

This function calculates the total clearance rate for a one compartment model where clearance is entirely due to metablism by the liver and glomerular filtration in the kidneys, identical to clearance of three compartment steady state model.

Usage

calc_total_clearance(chem.cas=NULL,chem.name=NULL,parameters=NULL,species="Human",
                     suppress.messages=F,default.to.human=F)

Arguments

chem.name

Either the chemical name, CAS number, or the parameters must be specified.

chem.cas

Either the chemical name, CAS number, or the parameters must be specified.

parameters

Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

suppress.messages

Whether or not the output message is suppressed.

default.to.human

Substitutes missing animal values with human values if true.

Details

When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.

Value

Total Clearance

Units of L/h/kg BW.

Author(s)

John Wambaugh

Examples

calc_total_clearance(chem.name="Ibuprofen")


[Package httkgui version 1.0 Index]