parameterize_1comp {httkgui}R Documentation

Parameterize_1comp

Description

This function initializes the parameters needed in the function solve_1comp.

Usage

 parameterize_1comp(chem.cas=NULL,chem.name=NULL,species="Human",
                    default.to.human=F)

Arguments

chem.name

Either the chemical name or the CAS number must be specified.

chem.cas

Either the chemical name or the CAS number must be specified.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

default.to.human

Substitutes missing rat values with human values if true.

Details

When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.

Value

Vdist

Volume of distribution, units of L/kg BW.

Fgutabs

Fraction of the oral dose absorbed, i.e. the fraction of the dose that enters the gutlumen.

kelim

Elimination rate, units of 1/h.

hematocrit

Percent volume of red blood cells in the blood.

kgutabs

Rate chemical is absorbed, 1/h.

million.cells.per.gliver

Millions cells per gram of liver tissue.

MW

Molecular Weight, g/mol.

Rblood2plasma

The ratio of the concentration of the chemical in the blood to the concentration in the plasma.

Author(s)

John Wambaugh

Examples

 parameters <- parameterize_1comp(chem.name='Bisphenol-A',species='Rat')
 parameters <- parameterize_1comp(chem.cas='80-05-7')
 

[Package httkgui version 1.0 Index]