calc_mc_oral_equiv {httkgui} | R Documentation |
This functions converts a chemical plasma concetration to an oral equivalent dose using a concentration obtained from calc_mc_css.
calc_mc_oral_equiv(conc,chem.name=NULL,chem.cas=NULL,which.quantile=0.95, species="Human",input.units='uM',output.units='mg', suppress.messages=F,return.samples=F,...)
conc |
Bioactive in vitro concentration in units of uM. |
chem.name |
Either the chemical name or the CAS number must be specified. |
chem.cas |
Either the CAS number or the chemical name must be specified. |
suppress.messages |
Suppress text messages. |
input.units |
Units of given concentration, default of uM but can also be mg/L. |
output.units |
Units of dose, default of 'mg' for mg/kg BW/ day or 'mol' for mol/ kg BW/ day. |
which.quantile |
Which quantile from Monte Carlo simulation is requested. Can be a vector. |
species |
Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human"). |
return.samples |
Whether or not to return the vector containing the samples from the simulation instead of the selected quantile. |
... |
Additional parameters passed to calc_mc_css. |
When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.
Equivalent dose in specified units, default of mg/kg BW/day.
John Wambaugh
calc_mc_oral_equiv(0.1,chem.cas="34256-82-1") calc_mc_oral_equiv(0.1,chem.cas="34256-82-1",which.quantile=c(0.05,0.5,0.95))