calc_elimination_rate {httkgui} | R Documentation |
This function calculates an elimination rate from the three compartment steady state model where elimination is entirely due to metablism by the liver and glomerular filtration in the kidneys.
calc_elimination_rate(chem.cas=NULL,chem.name=NULL,parameters=NULL,species="Human", suppress.messages=F,default.to.human=F)
chem.name |
Either the chemical name or the cas number must be specified. |
chem.cas |
Either the cas number or the chemical name must be specified. |
parameters |
Chemical parameters from parameterize_steadystate or 1compartment function, overrides chem.name and chem.cas. |
species |
Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human"). |
suppress.messages |
Whether or not the output message is suppressed. |
default.to.human |
Substitutes missing animal values with human values if true. |
When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.
Elimination rate |
Units of 1/h. |
John Wambaugh
calc_elimination_rate(chem.name="Bisphenol A") calc_elimination_rate(chem.name="Bisphenol A",species="Rat") calc_elimination_rate(chem.name="Bisphenol A",species="Rabbit") calc_elimination_rate(chem.cas="80-05-7")