parameterize_1comp {httkgui} | R Documentation |
This function initializes the parameters needed in the function solve_1comp.
parameterize_1comp(chem.cas=NULL,chem.name=NULL,species="Human", default.to.human=F)
chem.name |
Either the chemical name or the CAS number must be specified. |
chem.cas |
Either the chemical name or the CAS number must be specified. |
species |
Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human"). |
default.to.human |
Substitutes missing rat values with human values if true. |
When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.
Vdist |
Volume of distribution, units of L/kg BW. |
Fgutabs |
Fraction of the oral dose absorbed, i.e. the fraction of the dose that enters the gutlumen. |
kelim |
Elimination rate, units of 1/h. |
hematocrit |
Percent volume of red blood cells in the blood. |
kgutabs |
Rate chemical is absorbed, 1/h. |
million.cells.per.gliver |
Millions cells per gram of liver tissue. |
MW |
Molecular Weight, g/mol. |
Rblood2plasma |
The ratio of the concentration of the chemical in the blood to the concentration in the plasma. |
John Wambaugh
parameters <- parameterize_1comp(chem.name='Bisphenol-A',species='Rat') parameters <- parameterize_1comp(chem.cas='80-05-7')