calc_rblood2plasma {httkgui} | R Documentation |
This function calculates the constant ratio of the blood concentration to the plasma concentration. It uses the hematocrit and the red blood cell (RBC) parition coefficient as predicted by the Schmitt (2008) method.
calc_rblood2plasma(chem.cas=NULL, chem.name=NULL, default.to.human=F, species="Human")
chem.name |
Either the chemical name or the CAS number must be specified. |
chem.cas |
Either the CAS number or the chemical name must be specified. |
default.to.human |
Substitutes missing animal values with human values if true. |
species |
Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human"). |
When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.
John Wambaugh
Schmitt W. "General approach for the calculation of tissue to plasma partition coefficients." Toxicology In Vitro, 22, 457-467 (2008).
calc_rblood2plasma(chem.name="Bisphenol A") calc_rblood2plasma(chem.name="Bisphenol A",species="Rat")