calc_hepatic_clearance {httkgui}R Documentation

Calculate the hepatic clearance.

Description

This function calculates the hepatic clearance for a well-stirred model or other type if specified.

Usage

calc_hepatic_clearance(chem.name=NULL,chem.cas=NULL,parameters=NULL,species='Human',
                       hepatic.model='well-stirred',suppress.messages=F)

Arguments

chem.name

Either the chemical name, CAS number, or the parameters must be specified.

chem.cas

Either the chemical name, CAS number, or the parameters must be specified.

species

Species desired (either "Rat", "Rabbit", "Dog", "Mouse", or default "Human").

parameters

Chemical parameters from parameterize_steadystate function, overrides chem.name and chem.cas.

hepatic.model

Model used in calculating hepatic clearance, unscaled, parallel tube, dispersion, or default well-stirred.

suppress.messages

Whether or not to suppress the output message.

Details

When species is specified as rabbit, dog, or mouse, the function uses the appropriate physiological data(volumes and flows) but substitues human fraction unbound, partition coefficients, and intrinsic hepatic clearance.

Value

Hepatic Clearance

Units of L/h/kg BW.

Author(s)

John Wambaugh

Examples

calc_hepatic_clearance(chem.name="Ibuprofen")


[Package httkgui version 1.0 Index]