Published November 4, 2015 | Version v1
Journal article Open

Evaluation of antidiabetic activity of Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) leaf and bark in alloxan induced diabetic rats

  • 1. Centre for Entrepreneurship Development and Vocational Studies, Federal Polytechnic Ado Ekiti, Ekiti State, Nigeria
  • 2. Department of Biological Sciences, Federal University Dutsin-Ma, Katsina State, Nigeria
  • 3. Department of Zoology, University of Ibadan, Ibadan, Nigeria

Description

The study aimed to evaluate the antidiabetic effect of Irvingia gabonensis leaf and bark extracts on alloxan induced diabetic rats. Forty-four healthy rats were used in the experiment; they were grouped into eight groups. Alloxan was injected intraperitoneally and increase in the blood sugar level was confirmed after three days with glucometer (AccuCheck). The aqueous and ethanolic extracts of both leaf and bark at 150 and 250 mg/kg were orally administered daily for 16 days. Blood sugar level and body weight of each group were monitored and haematological parameters determined at the end of the experiment. Diabetic groups to which aqueous leaf extract at doses of 150 mg/l and 250 mg/l were administered showed significant decrease in blood sugar level from 463.50±29.32 and 381.33±39.77 to 103.50±4.50 and 97.00±2.00 respectively, compared to the positive group treated with glibenclamide, 468.67±30.82 to 86.67±2.73 (P<0.05). The body weight showed significant increased after the 8th day in group treated with aqueous leaf extract at dose of 150 mg/l and 250mg/l (191.25±16.84 to 207.7±37.90 and 147.35±0.85 to 150.60±1.20) when compared to the positive control group (164.07±5.76 to 171.57±4.81) at P<0.05. Aqueous extracts of leaf and bark of Irvingia gabonensis had more anti-diabetic activity than the ethanolic extracts. They also improved the haematological indices of the treated animals.

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