This poster presents work in the evaluation of children's anthropometric indicators in the context of the HYPIEND project. It is part of the project's effort to generate evidence on factors influencing child development and endocrine health.
", "publication_date": "2026-06-04", "publisher": "Zenodo", "resource_type": { "id": "poster", "title": { "de": "Poster", "en": "Poster" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "title": "M\u00e1s all\u00e1 de la pandemia: evaluaci\u00f3n antropom\u00e9trica infantil en el marco del proyecto HYPIEND" }, "parent": { "access": { "owned_by": { "user": "1119338" }, "settings": { "accept_conditions_text": null, "allow_guest_requests": false, "allow_user_requests": false, "secret_link_expiration": 0 } }, "communities": { "default": "8f3c0a03-2402-405f-8e43-65fc2fb60535", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_submission_policy": "open", "review_policy": "closed", "visibility": "public" }, "children": { "allow": false }, "created": "2024-06-03T15:35:44.780957+00:00", "custom_fields": { "subjects": [ { "id": "euroscivoc:39" }, { "id": "euroscivoc:117" }, { "id": "euroscivoc:179" }, { "id": "euroscivoc:195" }, { "id": "euroscivoc:695" } ] }, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "8f3c0a03-2402-405f-8e43-65fc2fb60535", "links": {}, "metadata": { "curation_policy": "", "description": "Understanding and preventing the impact of endocrine disruptors on the hypothalamus-pituitary axis in sensitive populations", "funding": [ { "award": { "id": "00k4n6c32::101137440" }, "funder": { "id": "00k4n6c32" } } ], "organizations": [ { "name": "Eurecat Technology Center" } ], "page": "Exposure to multiple endocrine disrupting chemicals (EDC) is an environmental insult that interferes with the development and function of the endocrine system, governed by the hypothalamus-pituitary (HP) axis. This interaction is specially concerning in developmental stages of life, such as the perinatal period and puberty. Despite the current body of knowledge on EDC actions on the endocrine system, a comprehensive, holistic understanding of the impact on the HP axis is still lacking.
\nHYPIEND aims to understand the effects of EDC co-exposure in the function and epigenetic programming of the HP axis to delineate interventional strategies for minimizing exposure and consequences on the neuroendocrine system during the perinatal and pre-pubertal stages. To do that, a computational toxicology methodological framework will be built leveraging public data and state of the art data analysis techniques to define EDC co-exposure patterns in target population. The resulting patterns will be evaluated in a sequential tiered approach consisting in cell-based screenings, Danio rerio models of HP axes, in vitro, in silico and in vivo models of placenta and blood brain barrier diffusion and new models of organoids-based organ-on-chip recapitulating the HP axis. EDC effects on epigenetic programming will be evaluated in preclinical models of perinatal and early childhood. Whole genome DNA methylation patterns in the different models will be explored as a source of non-invasive biomarkers of HP axis disruption by EDC.
\nThe knowledge generated in preclinical models will be applied in two multi-centre-controlled intervention studies intended to minimize exposure to EDC in children in the perinatal and pre-puberty stages. HYPIEND outcomes will be novel approach methodologies based in in vitro and in silico models, non-invasive biomarkers of HP disruption by EDC and new intervention strategies to minimize EDC exposure in sensitive population.
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