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This dataset is derived from PubChem BioAssay AID 1347036, titled \"Progesterone receptor (PR) small molecule agonists, qHTS assay: Summary\".
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The original assay is part of the Tox21 program and measures activation of progesterone receptor (PR) signaling using a beta-lactamase reporter assay in HEK293 cells engineered with a PR-responsive reporter system.
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Original dataset statistics: - Tested compounds: 7,671 - Active (agonists): 117 - Inactive: 7,408
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Data preprocessing:
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- Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations.
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Final cleaned dataset:
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- Total compounds: 7,448 - Positive (agonists): 106 - Negative (inactive): 7,342
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