miRNA,logFC,DE_adj_P,Regulation,Top5_downregulated_flag,Individual_enrichment_BH_significant,n_functional_targets,n_aging_targets,Enrichment_ratio,Hypergeometric_P,BH_adjusted_P,Layer_C_decision,Audit_rationale
hsa-miR-203a,-4.66203,0.0011009,Down,Yes,No,0,0,NA,NA,NA,Excluded from Layer C; follow-up context candidate,"Strongest downregulated miRNA, but no Functional MTI-supported aging-related target overlap in the available files."
hsa-miR-20a-5p,-3.63329,0.00285579,Down,Yes,Yes,62,31,2.63265,2.5664e-08,4.87616e-07,Layer C primary candidate,Top-five downregulated miRNA and BH-significant individual validated-aging enrichment.
hsa-miR-4454,-3.61029,0.000476955,Down,Yes,No,4,2,2.63265,0.165418,0.273299,Layer C sensitivity contributor,Top-five downregulated miRNA with two aging-related targets; retained for audit and sensitivity analysis.
hsa-miR-126-3p,-3.49489,0.0185606,Down,Yes,No,44,14,1.67532,0.0284207,0.0568415,Layer C secondary context candidate,Top-five downregulated miRNA with nominal individual enrichment and VEGFA/vascular-context support.
hsa-miR-16-5p,-3.32647,0.00285579,Down,Yes,Yes,64,35,2.87946,1.23221e-10,4.68241e-09,Layer C primary candidate,Top-five downregulated miRNA and BH-significant individual validated-aging enrichment.
hsa-miR-200c-3p,-2.91783,0.00223929,Down,No,Yes,77,34,2.32494,2.6314e-07,3.33311e-06,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-181a-5p,1.72942,0.0430555,Up,No,Yes,72,32,2.34014,4.99402e-07,4.74432e-06,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-200b-3p,-2.82238,0.0308464,Down,No,Yes,59,27,2.40955,1.98685e-06,1.51001e-05,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-17-5p,-3.00675,0.00833014,Down,No,Yes,80,33,2.17194,2.60926e-06,1.65253e-05,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-106a-5p,-2.96917,0.0139314,Down,No,Yes,34,18,2.78752,8.47935e-06,4.60308e-05,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-10b-5p,-2.84179,0.031952,Down,No,Yes,26,14,2.83516,6.90551e-05,0.000328012,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-24-3p,-2.43222,0.00651143,Down,No,Yes,76,28,1.93985,0.000168727,0.000712404,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-146a-5p,-2.94908,0.022356,Down,No,Yes,62,24,2.03818,0.000205375,0.000780426,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-130b-3p,-2.1489,0.0251821,Down,No,Yes,30,14,2.45714,0.000488867,0.00168881,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-182-5p,-2.6859,0.0243658,Down,No,Yes,51,20,2.06483,0.000567695,0.0017977,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-29b-1-5p,1.03419,0.0383251,Up,No,Yes,8,6,3.94898,0.000905704,0.00264744,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-21-5p,-2.82934,0.00603465,Down,No,Yes,125,38,1.60065,0.00117028,0.00317647,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-708-5p,-3.30616,0.0126832,Down,No,Yes,20,10,2.63265,0.00166297,0.00421287,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-486-3p,1.47308,0.0253643,Up,No,Yes,10,6,3.15918,0.00479426,0.0113864,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-486-5p,2.55154,0.0243658,Up,No,Yes,25,10,2.10612,0.0118198,0.0264207,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."
hsa-miR-103a-3p,-1.70259,0.0305254,Down,No,Yes,26,10,2.02512,0.0160263,0.0338334,Audit-only enrichment hit outside Layer C,"BH-significant individual validated-aging enrichment, but excluded from the top-five-downregulated Layer C rule."