Tabular data for the following experiments:
\nAnalysis of synaptic localization of pSYN, synaptic density, and association of synaptic pSYN to pSYN positive neurites_AS: Synaptic localization of pSYN, synaptic density, and puncta size changes (relative to Lewy neurites), as well as the association of synaptic pSYN with pSYN-positive neurites, were quantified.
\nSEQUIN for VGLUT1, VGLUT2 and VGAT positive synaspes_SS: Synaptic loci frequency distributions and synapse densities for VGLUT1- and VGLUT2-positive excitatory synaptic loci and VGAT-positive inhibitory synaptic loci were quantified.
\nVGLUT1 and VGLUT2 colocalization with endogenous α-synuclein_SS: Colocalization of VGLUT1 and VGLUT2 with endogenous α-synuclein was quantified in the cortex.
\nElectron Microscopy analysis of excitatory synapses_JR_DR: Ultrastructural measures were quantified, including synaptic vesicle area, intervesicular distance, and synaptic cleft distance.
\npSyn pathology negatively impacts excitatory transmission_JG: Electrophysiology data from cortical slices were analyzed to assess how pSyn pathology affects synaptic transmission.
\npSyn pathology progressively increases_SS: Lewy pathology progression at 1, 2, and 3 months post–striatal PFF injection was quantified.
\n", "funding": [ { "award": { "number": "020616", "title": { "en": "Understanding and Manipulating Cellular and Circuit-Level Vulnerability to Neurodegeneration in Parkinson\u2019s disease " } }, "funder": { "id": "03zj4c476", "name": "Aligning Science Across Parkinson's" } } ], "publication_date": "2026", "publisher": "Zenodo", "resource_type": { "id": "dataset", "title": { "de": "Datensatz", "en": "Dataset" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "title": "Progressive Vulnerability of Cortical Synapses in \u03b1-Synucleinopathy: Dataset" }, "parent": { "access": { "owned_by": { "user": "1187579" }, "settings": { "accept_conditions_text": null, "allow_guest_requests": false, "allow_user_requests": false, "secret_link_expiration": 0 } }, "communities": { "default": "8d70e99e-d005-4ad3-814b-6560de123def", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_submission_policy": "open", "review_policy": "members", "visibility": "public" }, "children": { "allow": false }, "created": "2021-03-22T18:04:38.253618+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "8d70e99e-d005-4ad3-814b-6560de123def", "links": {}, "metadata": { "curation_policy": "
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