Serum Magnesıum and Intra-Erythrocyte Magnesıum Levels in Patıents with Acute Myocardıal Infarctus

Introduction: In this study, we intended to commentate on whether serum-Magnesium (S-Mg') and intra-erythrocytic-Magnesium (Ie-Mg'*) levels are a risk factor for acute myocardial infarction in patients diagnosed with acute myocardial infarction (AMI).

Materials and Methods: The study included 57 (44 Male, 13 Female) patients with acute myocardial infarction and 35 control cases (23 Male, 12 Female) who did not have any coronary artery disease and did not use any medication affecting Magnesium (Mg) levels. Blood samples were taken from the patients included in the study and the individuals in the control group to measure S-Mg and Ie-Mg levels. In addition, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and total cholesterol (Total-C) levels of both the patient and control groups were measured. The patient and control groups were compared in terms of serum and intra-erythrocytic Mg levels. Besides, it was also examined whether there was a statistical correlation between the S-Mg' and Ie-Mg” levels of the patient and control groups and age, gender, and smoking.

Findings: While S-Mg* levels were found to be significantly lower in the patient group with acute myocardial infarction, no significant difference was found between the patient and control groups in terms of Ie-Mg levels. This shows us that Mg decreases in the extracellular space in the acute phase of infarction and may be a risk factor for coronary artery disease. Additionally, we did not find any relationship between age and smoking and S-Mg' and Ie-Mg” levels in the patient group.

As a result, we can propound that serum magnesium level is low in patients with AMI. Therefore, we think that using Mg* therapy after infarction may benefit these patients due to the cardioprotective properties of Mg. Within the difficulties of measuring  intra- erythrocytic-Magnesium levels and because of the cost-effectivity, also there is no statistical difference between patient and control groups, it would be enough measuring of serum Mg levels to evaluate this subject.