EFFECT OF CAFFEINE ON SOME BEHAVIORAL INDICATORS OF ALCOHOLIZED MALE WHITE RATS WITH DIFFERENT LEVELS OF ANXIETY

Caffeine administered to alcoholized individuals enhances the ethanol-induced tendencies in some subgroups of rats: the anxiolytic in males with initially moderate and low levels of anxiety; the depression of exploratory behavior in animals with extreme levels of anxiety and motor in non-anxious individuals. In addition, caffeine mitigates the antidepressant effect of 14-day ethanol administration in rats with initially moderate and high levels of anxiety. When combined with ethanol, caffeine changes the direction of anxiety in high-anxiety males and has a multidirectional effect on emotional behavior.