Annotation
literal: Ontology designed for the definition of parameters for the purpose of simulation by Discrete Events

SubClassOf
data some values from: DataProperty
data some values from: DataOneOf
  literal: ANNUAL
  literal: LIFETIME
  literal: ONETIME

SubClassOf
data exact cardinality: DataProperty
data exact cardinality: DataOneOf
  literal: ACUTE
  literal: CHRONICAL

SubClassOf
data some values from: DataProperty
data some values from: DataOneOf
  literal: DISUTILITY
  literal: UTILITY

SubClassOf
data some values from: DataProperty
data some values from: DataOneOf
  literal: ANNUAL
  literal: LIFETIME
  literal: ONETIME

DataPropertyAssertion
literal: 1.0

DataPropertyAssertion
literal: 1.0

DataPropertyAssertion
literal: 1.0

DataPropertyAssertion
literal: 1

DataPropertyAssertion
literal: Quantitative enzymatic determination of biotinidase activity in serum and plasma,and analysis of mutations of the biotinidase gene.

DataPropertyAssertion
literal: 509.65#UNIFORM(409.65, 609.65)

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Cost of diagnosis for profound BD in Spain. Includes retest for screening, two diagnostic tests and two blood extraction.

DataPropertyAssertion
literal: ONETIME

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 616.75672

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Cost for annual ophthalmologic, auditory, and medical geneticist or metabolic specialist evaluations, and urinary organic acid and acylcarnitine analyses

DataPropertyAssertion
literal: ANNUAL

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 155.14

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Annual costs for hearing problems.

DataPropertyAssertion
literal: ANNUAL

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 31169.95

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Initial costs for hearing problems.

DataPropertyAssertion
literal: ONETIME

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 3665.56

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Annual costs for hypotonia.

DataPropertyAssertion
literal: ONETIME

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 217.74

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Annual costs for mental delay.

DataPropertyAssertion
literal: ANNUAL

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 1218.02

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Initial costs for mental delay.

DataPropertyAssertion
literal: ONETIME

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 3665.56

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Annual costs for seizures.

DataPropertyAssertion
literal: ONETIME

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 3665.56

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Annual costs for skin problems.

DataPropertyAssertion
literal: ONETIME

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 121.86

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Annual costs for vision loss.

DataPropertyAssertion
literal: ANNUAL

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 251.8

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Initial costs for vision loss.

DataPropertyAssertion
literal: ONETIME

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 0.89#UNIFORM(0.5, 2.5)

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Cost of screening test for profound biotinidase deficiency in Spain

DataPropertyAssertion
literal: ONETIME

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: 66.2475

DataPropertyAssertion
literal: SPAIN

DataPropertyAssertion
literal: Cost of annual use of biotin for profound biotinidase deficiency

DataPropertyAssertion
literal: ANNUAL

DataPropertyAssertion
literal: 2013

DataPropertyAssertion
literal: Ophthalmologic, auditory, and medical geneticist or metabolic specialist evaluations and urinary organic acid and acylcarnitine analyses.

DataPropertyAssertion
literal: NO_SCREENING

DataPropertyAssertion
literal: SCREENING

DataPropertyAssertion
literal: 1.0

DataPropertyAssertion
literal: 0.515#BETA(24,34)

DataPropertyAssertion
literal: 1.0

DataPropertyAssertion
literal: 0.0

DataPropertyAssertion
literal: 0.457#BETA(17,20)

DataPropertyAssertion
literal: -9.6#GAMMA(25,0.38)

DataPropertyAssertion
literal: 1.0

DataPropertyAssertion
literal: 0.557#BETA(14,6)

DataPropertyAssertion
literal: 1.0

DataPropertyAssertion
literal: 0.0

DataPropertyAssertion
literal: 0.564#BETA(65,50)

DataPropertyAssertion
literal: 1.0

DataPropertyAssertion
literal: 0.0

DataPropertyAssertion
literal: 0.41#BETA(24,34)

DataPropertyAssertion
literal: 1.0

DataPropertyAssertion
literal: 0.175#BETA(19,91)

DataPropertyAssertion
literal: *0.0

DataPropertyAssertion
literal: NATURAL

DataPropertyAssertion
literal: 82.272854#GAMMA(25, 3.29)

DataPropertyAssertion
literal: 0

DataPropertyAssertion
literal: 1.47884E-05#BETA(8, 540955)

DataPropertyAssertion
literal: The Genetic and Rare Diseases Information Center (GARD) is a program which includes an online database of disease-specific information. The Orphanet Rare Diseases Ontology (ORDO), which is anontology that captures relationships among diseases, genes and other features The Online Mendelian Inheritance in Man (OMIM), which is an online catalog on phenotypes and genotypes, and the relationships between them.

DataPropertyAssertion
literal: 1

DataPropertyAssertion
literal: Measurement of biotinidase activity in blood-saturated filter paper samples on enzymatic assay or semiquantitative fluorometric determination. After a positive, the analysis is repeated twice.

DataPropertyAssertion
literal: Measurement of biotinidase activity in blood-saturated filter paper samples on enzymatic assay or semiquantitative fluorometric determination

DataPropertyAssertion
literal: BioActivity

DataPropertyAssertion
literal: 1.0

DataPropertyAssertion
literal: 0.999935#BETA(540904,35)

DataPropertyAssertion
literal: 1.7

DataPropertyAssertion
literal: Lifetime treatment with biotin

DataPropertyAssertion
literal: UTILITY

DataPropertyAssertion
literal: 0.8761#BETA(5.6,0.79)

DataPropertyAssertion
literal: UTILITY

DataPropertyAssertion
literal: 0.8861#BETA(5.2,0.67)

DataPropertyAssertion
literal: UTILITY

DataPropertyAssertion
literal: 0.8161#BETA(1.71,0.39)

DataPropertyAssertion
literal: EQ-5D??

DataPropertyAssertion
literal: UTILITY

DataPropertyAssertion
literal: Carroll et al

DataPropertyAssertion
literal: 0.8461#BETA(1.65, 0.30)

DataPropertyAssertion
literal: UTILITY

DataPropertyAssertion
literal: 0.8861#BETA(5.2,0.67)

DataPropertyAssertion
literal: UTILITY

DataPropertyAssertion
literal: 0.8861#BETA(5.2,0.67)

DataPropertyRange
data one of:
  literal: MODIFIED
  literal: NATURAL

DataPropertyRange
data one of:
  literal: NO_SCREENING
  literal: SCREENING

DataPropertyRange
data one of:
  literal: ACUTE
  literal: CHRONICAL

DataPropertyRange
data one of:
  literal: DISUTILITY
  literal: UTILITY

DataPropertyRange
data one of:
  literal: ANNUAL
  literal: LIFETIME
  literal: ONETIME

AnnotationAssertion
IRI: #Cost
literal: Costs are always assumed to be annual.

AnnotationAssertion
IRI: #Disease
literal: Common definition for common diseases.

AnnotationAssertion
IRI: #Disease
literal: Disease

AnnotationAssertion
IRI: #References
literal: This entity has relationships with other repositories

AnnotationAssertion
IRI: #hasAgeOfFirstPresentation
literal: Age of First Presentation

AnnotationAssertion
IRI: #hasCountry
literal: Country in which the cost data is collected

AnnotationAssertion
IRI: #hasDescription
literal: Description of the cost

AnnotationAssertion
IRI: #hasDose
literal: Dosage of the indicated drug

AnnotationAssertion
IRI: #hasFrequency
literal: Indicates the time cycle of how often the treatment, the follow-up test or their respective strategies have to be applied. In the case of a manifestation of the disease, it will indicate how many times a year the symptom manifests itself. By default = 1, for the Manifestations.

AnnotationAssertion
IRI: #hasHoursInterval
literal: Interval in which the indicated dose of drug should be given.

AnnotationAssertion
IRI: #hasIdentifier
literal: Stores the identifier of an instance. The objective of this field is to facilitate the identification and relationship between instances with a view to software programming.

AnnotationAssertion
IRI: #hasKindIntervention
literal: Kind

AnnotationAssertion
IRI: #hasKindManifestation
literal: Acute or Chronical

AnnotationAssertion
IRI: #hasLifeExpectancy
literal: Life Expectancy

AnnotationAssertion
IRI: #hasMortalityFactor
literal: By default = 1

AnnotationAssertion
IRI: #hasPrevalenceAtBirth
literal: The prevalence of a disease is the total number of individuals presenting an attribute or disease at a time or during a period divided by the population at that point in time or in the middle of the period. Quantifies the proportion of people in a population who have a disease (or any other event) at a given time and provides an estimate of the proportion of subjects in that population who have the disease at that time.

AnnotationAssertion
IRI: #hasProbability
literal: Probability

AnnotationAssertion
IRI: #hasRange
literal: Age range in which the drug will be delivered.

AnnotationAssertion
IRI: #hasSensitivity
literal: The Sensitivity in epidemiology is the Probability of correctly classifying a sick individual, that is, the Probability that a positive result will be obtained in a diagnostic test for a sick subject. The Sensitivity is, therefore, the ability of the complementary test to detect the disease. Sensitivity is the percentage of true positives or the Probability that the test is positive if the disease is present; False negatives are sick subjects diagnosed as healthy.

AnnotationAssertion
IRI: #hasSpecificity
literal: Start Age

AnnotationAssertion
IRI: #hasSpecificity
literal: The Specificity of a test is the Probability that a healthy subject will have a negative test result. Specificity is the percentage of true negatives or the Probability that the test will be negative if the disease is not present. False positives are healthy subjects diagnosed as sick.

AnnotationAssertion
IRI: #hasStage
literal: Stage of the development of the disease

AnnotationAssertion
IRI: #hasTemporalBehavior
literal: ONETIME: the cost/utility applies only once at the time of the event. LIFETIME: the cost/utility the cost represents the total applied to the patient's life. ANNUAL: the cost/utility indicates that the indicated value affects annually throughout the patient's life.

AnnotationAssertion
IRI: #hasTemporaryThreshold
literal: Time limit in which the sample must be made. For example on the third day of birth. This value must be expressed in number of days.

AnnotationAssertion
IRI: #hasYear
literal: Year in which the cost data is collected

AnnotationAssertion
literal: hasDiseaseClinicalDiagnosisStrategy Domain Disease

AnnotationAssertion
literal: true

AnnotationAssertion
literal: hasDevelopment Domain DevelopmentModification

AnnotationAssertion
literal: true

AnnotationAssertion
literal: hasReferences Domain Disease

AnnotationAssertion
literal: true

AnnotationAssertion
literal: hasInterventions Domain Disease

AnnotationAssertion
literal: true

AnnotationAssertion
literal: DevelopmentModification DisjointWith Disease

AnnotationAssertion
literal: true

AnnotationAssertion
literal: hasReferences Domain Disease

AnnotationAssertion
literal: true

AnnotationAssertion
literal: DevelopmentModification DisjointWith Disease

AnnotationAssertion
literal: true

AnnotationAssertion
literal: hasDiseaseClinicalDiagnosisStrategy Domain Disease

AnnotationAssertion
literal: true

AnnotationAssertion
literal: hasDevelopment Domain DevelopmentModification

AnnotationAssertion
literal: true

AnnotationAssertion
literal: PBD_ProfoundBiotinidaseDeficiency Type Disease

AnnotationAssertion
literal: true

AnnotationAssertion
literal: hasInterventions Domain Disease

AnnotationAssertion
literal: true