Published October 3, 2025 | Version v5
Preprint Open

Golden rules for building sustainable bioinformatics capacity using Nextflow and nf-core with a focus on early-mid career researchers: The Kids Research Institute Australia, case report.

Authors/Creators

  • 1. Wal-Yan Respiratory Research Centre, The Kids Research Institute Australia, 6009, Perth, Western Australia, Australia.
  • 2. Department of Respiratory and Sleep Medicine, Perth Children's Hospital, 6009, Perth, Western Australia, Australia.
  • 3. Seqera, Carrer de Maria Aguilo, 28, Barcelona, 08005, Spain.
  • 4. DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research; SAMRC Centre for Tuberculosis Research; Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, 7505, Cape Town, Western Cape, South Africa.

Description

The increasing adoption of high-throughput "omics" technologies has heightened the demand for standardized, scalable, and reproducible bioinformatics workflows. Nextflow and nf-core provide a robust framework for researchers, particularly early- and mid-career researchers (EMCRs), to navigate complex data analysis. At The Kids Research Institute Australia, we implemented a structured approach to bioinformatics capacity building using these tools. This perspective presents nine practical “golden” rules that facilitated the successful adoption of Nextflow and nf-core, addressing implementation, knowledge gaps, resource allocation, and community support. Our experience serves as a guide for institutions

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Additional details

Related works

Is published in
Publication: 10.3389/fbinf.2025.1610015 (DOI)

Dates

Submitted
2025-04-11

References