EVIDENCE: {'Observed_samples': {'Present_SOLO_SR': 18, 'Present_SOLO_R': 12, 'Present_SOLO_S': 6}, 'Additional grading criteria applied': 'Borderline', 'FINAL CONFIDENCE GRADING': '1) Assoc w R', 'INITIAL CONFIDENCE GRADING': '3) Uncertain significance', 'WHO HGVS': 'rpoB_p.His445Ser'}