SPINA Carb
Authors/Creators
- 1. Catholic Hospitals Bochum
-
2.
Ruhr University Bochum
-
3.
Klinik Blankenstein
Contributors
Project member (2):
- 1. Lee Kong Chian School of Medicine, Nanyang Technological University Singapore
- 2. King's College London
Description
Structure parameter inference approach for endocrine feedback control
SPINA is software for determining constant structure parameters of endocrine feedback control systems from hormone levels obtained in vivo.
The first version of this cybernetic approach (SPINA Thyr, provided elsewhere) allows for evaluating the functional status of the thyroid gland, i.e. thyroid's secretory capacity (GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD). The software additionally provides means to calculate Jostel's TSH index (JTI) and the thyrotroph thyroid hormone sensitivity index (TTSI), two parameters for the assessment of the anterior pituitary function and the location of the set point of thyroid homeostasis.
A second version (SPINA Carb, this repository) has been developed for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells (SPINA-GBeta), an estimate for the insulin receptor gain (SPINA-GR) and a static disposition index as a measure for the loop gain of the feedback loop (SPINA-DI).
Both implementations of SPINA have been validated in clinical studies based on large cohorts.
Files
SPINA_Carb_V5_1_1_Handbook_and_Reference.pdf
Files
(25.6 MB)
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Additional details
Related works
- Is part of
- Software: http://spina.sf.net (URL)
- Is supplement to
- Journal article: 10.1038/s41598-022-22531-3 (DOI)
- Journal article: 10.1111/1753-0407.13525 (DOI)
Funding
- Deutsche Forschungsgemeinschaft
- GRK 1041
- Ruhr University Bochum
- Open Access Publication Funds
Dates
- Available
-
2025-07-13
- Updated
-
2025-07-13
Software
- Repository URL
- https://svn.code.sf.net/p/spina/code/
- Programming language
- Pascal
- Development Status
- Active
References
- Dietrich JW, Dasgupta R, Anoop S, Jebasingh F, Kurian ME, Inbakumari M, Boehm BO, Thomas N. SPINA Carb: a simple mathematical model supporting fast in-vivo estimation of insulin sensitivity and beta cell function. Sci Rep. 2022 Oct 21;12(1):17659. doi: 10.1038/s41598-022-22531-3. PMID: 36271244; PMCID: PMC9587026.
- Dietrich JW, Abood A, Dasgupta R, Anoop S, Jebasingh FK, Spurgeon R, Thomas N, Boehm BO. A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis. J Diabetes. 2024 Sep;16(9):e13525. doi: 10.1111/1753-0407.13525. Epub 2024 Jan 2. PMID: 38169110; PMCID: PMC11418405.