Published January 28, 2025 | Version v1
Dataset Open

Ultra-high resolution multimodal MRI densely labelled holistic structural brain atlas

Authors/Creators

  • 1. ROR icon Laboratoire Bordelais de Recherche en Informatique
  • 2. ROR icon Universitat de València
  • 3. EPHE
  • 4. ROR icon Université de Bordeaux
  • 5. ROR icon Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana

Description

We introduce a novel structural holistic Atlas (holiAtlas) of the human brain anatomy based on multimodal and high-resolution MRI that covers several anatomical 
levels from the organ to the substructure level, using a new densely labelled protocol generated from the fusion of multiple local protocols at different scales. This atlas was constructed by averaging images and segmentations of 75 healthy subjects from the Human Connectome Project database. Specifically, MR images of T1, T2 and WMn 
(White Matter nulled) contrasts at 0.125 mm3 resolution were selected for this project.
The images of these 75 subjects were nonlinearly registered and averaged using symmetric group-wise normalisation to construct the atlas. At the finest level, the 
proposed atlas has 350 different labels derived from 7 distinct delineation protocols.These labels were grouped at multiple scales, offering a coherent and consistent holistic representation of the brain across different levels of detail. This multiscale and multimodal atlas can be used to develop new ultra-high-resolution segmentation 
methods, potentially improving the early detection of neurological disorders. We make it publicly available to the scientific communit

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Additional details

Related works

Is source of
Journal article: arXiv:2501.16879 (arXiv)

Funding

Ministerio de Ciencia, Innovación y Universidades
AEI/10.13039/50110001103
Agence Nationale de la Recherche
ANR-18-CE45-0013
Agence Nationale de la Recherche
ANR-23-CE45-0020-01
Agence Nationale de la Recherche
ANR-20-CHIA-0027-01
Agence Nationale de la Recherche
ANR-23-IAHU-0001