DRUG_ID,DRUG_NAME,DRUG_MECHANISM,DRUG_TARGET,EVIDENCE_SCORE (Source: ChatGPT),TRIAL_LINK
1,Mescasermin (rhIGF-1),Replaces/boosts IGF-1 growth factor,"Growth factor deficiency, IGF1R",7,"NCT01777542 (Rett trial, negative), Phase 1 open-label (safety)"
2,Minocycline,"Anti-inflammatory, MMP-9 inhibition, microglial modulation","Neuroinflammation, microglial overactivity, Microglia, MMP-9",5,"NCT01546453 (Angelman, negative), FXS RCT (PMID: 22228579, positive)"
3,Baclofen (Arbaclofen),GABA_B receptor agonist (restores inhibitory tone),"GABAergic dysfunction, GABA_B receptor (GABBR1/2)",4,"NCT01282268 & NCT01325220 (Fragile X, negative), No Rett trials"
4,Memantine,NMDA receptor antagonist (reduces excitotoxicity),"Excess glutamatergic signaling, NMDA receptor (GRIN1/2B)",3,"Forest Labs ASD trials (2013, negative), Approved in AD, No Rett"