Scientific Review on PerioCream and NitrAdine: From Microbiota Modulation to Clinical Efficacy in Periodontal Therapy

This scientific review explores the microbiological, clinical, and therapeutic potential of PerioCream, a NitrAdine-based mucoadhesive periodontal paste. PerioCream is designed as an adjunct to Scaling and Root Planing (SRP) to enhance healing, reduce microbial recolonization, and improve patient-reported outcomes.

The study provides a comprehensive analysis of previous research, highlighting:
📌 The antimicrobial and bioadhesive properties of NitrAdine formulations.
📌 Comparative efficacy of PerioCream versus chlorhexidine (CHX), photodynamic therapy (aPDT), and probiotic-based adjuncts.
📌 Rationale for the 2025 clinical investigation, assessing real-world effectiveness using HRQL (Health-Related Quality of Life) and VAS (Visual Analogue Scale) assessments.

This review serves as a scientific foundation for the upcoming clinical study, contributing to the growing body of evidence on non-antibiotic periodontal therapies.

🔗 For more research and updates, visit the NitrAdine & PerioCream Research Hub.