article_metadata: Naoya Kuwahara Taiichi Kodaka Yuriko Zushi Miho Sasaki Takae Goka Hayato Maruoka Yumi Aoyama Hiroko Tsunemine Taku Yamane Jun Kobayashi Toru Kawakami Fumihiro Ishida Tomoo Itoh Takayuki Takahashi
article_metadata: 10.3960/jslrt.19030
article_metadata: J Clin Exp Hematop
article_metadata: 2019;59(4):202-206.
article_metadata: cd4 cd8 t-cell large granular lymphocytic leukemia autoimmune neutropenia clonal b-lymphocytosis immune thrombocytopenia
article_metadata: CC BY-NC-SA
article_metadata: https://pubmed.ncbi.nlm.nih.gov/31866622/
article_metadata: B-Lymphocytes / metabolism B-Lymphocytes / pathology CD4-Positive T-Lymphocytes / metabolism CD4-Positive T-Lymphocytes / pathology CD8-Positive T-Lymphocytes / metabolism CD8-Positive T-Lymphocytes / pathology Leukemia, Large Granular Lymphocytic / genetics Leukemia, Large Granular Lymphocytic / metabolism Leukemia, Large Granular Lymphocytic / pathology Lymphocytosis / genetics Lymphocytosis / metabolism Lymphocytosis / pathology Mutation, Missense Neoplasm Proteins / genetics Neoplasm Proteins / metabolism Neutropenia / genetics Neutropenia / metabolism Neutropenia / pathology Purpura, Thrombocytopenic, Idiopathic / genetics Purpura, Thrombocytopenic, Idiopathic / metabolism Purpura, Thrombocytopenic, Idiopathic / pathology STAT3 Transcription Factor / genetics STAT3 Transcription Factor / metabolism
article_metadata: B-Lymphocytes / metabolism B-Lymphocytes / pathology CD4-Positive T-Lymphocytes / metabolism CD4-Positive T-Lymphocytes / pathology CD8-Positive T-Lymphocytes / metabolism CD8-Positive T-Lymphocytes / pathology Leukemia, Large Granular Lymphocytic / genetics Leukemia, Large Granular Lymphocytic / metabolism Leukemia, Large Granular Lymphocytic / pathology Lymphocytosis / genetics Lymphocytosis / metabolism Lymphocytosis / pathology Mutation, Missense Neoplasm Proteins / genetics Neoplasm Proteins / metabolism Neutropenia / genetics Neutropenia / metabolism Neutropenia / pathology Purpura, Thrombocytopenic, Idiopathic / genetics Purpura, Thrombocytopenic, Idiopathic / metabolism Purpura, Thrombocytopenic, Idiopathic / pathology STAT3 Transcription Factor / genetics STAT3 Transcription Factor / metabolism Case Reports Aged, 80 and over Amino Acid Substitution Female Humans Immunoglobulin lambda-Chains / genetics Immunoglobulin lambda-Chains / metabolism Immunoglobulin lambda-Chains Neoplasm Proteins STAT3 Transcription Factor STAT3 protein, human
article_metadata: PMC6954171
article_metadata: 31866622
article_metadata: T-cell large granular lymphocytic (LGL) leukemia consists of CD4+/CD8dim and CD4-/CD8+ LGL populations in association with immune thrombocytopenia, autoimmune neutropenia, and monoclonal B-cell lymphocytosis
article_metadata: 2019