article_metadata: Toshikage Nagao Tetsuya Kurosu Yoshihiro Umezawa Ayako Nogami Gaku Oshikawa Shuji Tohda Masahide Yamamoto Osamu Miura
article_metadata: 10.1371/journal.pone.0084746
article_metadata: PLoS One
article_metadata: 2014 Jan 3;9(1):e84746.
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/24404189/
article_metadata: Adaptor Proteins, Signal Transducing / metabolism Glycogen Synthase Kinase 3 / metabolism Janus Kinase 2 / metabolism Leukemia, Myeloid, Acute / metabolism Phosphoproteins / metabolism Polycythemia Vera / metabolism Ribosomal Protein S6 Kinases, 70-kDa / metabolism src-Family Kinases / metabolism
article_metadata: Adaptor Proteins, Signal Transducing / metabolism Glycogen Synthase Kinase 3 / metabolism Janus Kinase 2 / metabolism Leukemia, Myeloid, Acute / metabolism Phosphoproteins / metabolism Polycythemia Vera / metabolism Ribosomal Protein S6 Kinases, 70-kDa / metabolism src-Family Kinases / metabolism Case Reports Research Support, Non-U.S. Gov't Apoptosis / drug effects Bone Marrow / metabolism Bone Marrow / pathology Cell Cycle Proteins Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Cell Survival / genetics Cell Transformation, Neoplastic / genetics Cell Transformation, Neoplastic / metabolism DNA Mutational Analysis Dasatinib Female Humans Janus Kinase 2 / genetics Karyotype Leukemia, Myeloid, Acute / diagnosis Leukemia, Myeloid, Acute / genetics Middle Aged Mutation Phosphorylation / drug effects Polycythemia Vera / diagnosis Polycythemia Vera / genetics Protein Kinase Inhibitors / pharmacology Pyrimidines / pharmacology Signal Transduction / drug effects Thiazoles / pharmacology src-Family Kinases / genetics Adaptor Proteins, Signal Transducing Cell Cycle Proteins EIF4EBP1 protein, human Phosphoproteins Protein Kinase Inhibitors Pyrimidines Thiazoles Janus Kinase 2 lyn protein-tyrosine kinase src-Family Kinases Ribosomal Protein S6 Kinases, 70-kDa Glycogen Synthase Kinase 3 Dasatinib
article_metadata: PMC3880321
article_metadata: 24404189
article_metadata: Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera
article_metadata: 2014