article_metadata: Jun Li Bing Wei Junnan Feng Xinxin Wu Yuxi Chang Yi Wang Xiuli Yang Haiyan Zhang Sile Han Cuiyun Zhang Jiawen Zheng Harry J M Groen Anke van den Berg Jie Ma Hongle Li Yongjun Guo
article_metadata: 10.3389/fendo.2022.1006480
article_metadata: Front Endocrinol (Lausanne)
article_metadata: 2022 Dec 13;13:1006480.
article_metadata: myc amplification tp53 and rb1 loss lung adenocarcinoma osimertinib small cell lung cancer transformation
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/36583000/
article_metadata: Adenocarcinoma of Lung / genetics Lung Neoplasms / drug therapy Lung Neoplasms / genetics Lung Neoplasms / pathology Small Cell Lung Carcinoma / genetics
article_metadata: Adenocarcinoma of Lung / genetics Lung Neoplasms / drug therapy Lung Neoplasms / genetics Lung Neoplasms / pathology Small Cell Lung Carcinoma / genetics Case Reports Research Support, Non-U.S. Gov't ErbB Receptors / genetics Female Humans In Situ Hybridization, Fluorescence Phosphatidylinositol 3-Kinases / genetics Retinoblastoma Binding Proteins / genetics Retrospective Studies Tumor Suppressor Protein p53 / genetics Ubiquitin-Protein Ligases / genetics Tumor Suppressor Protein p53 Phosphatidylinositol 3-Kinases ErbB Receptors TP53 protein, human RB1 protein, human Ubiquitin-Protein Ligases Retinoblastoma Binding Proteins
article_metadata: PMC9792468
article_metadata: 36583000
article_metadata: Case report: TP53 and RB1 loss may facilitate the transformation from lung adenocarcinoma to small cell lung cancer by expressing neuroendocrine markers
article_metadata: 2022