article_metadata: Hiroko Tsunemine Yuriko Zushi Miho Sasaki Yuko Nishikawa Akiyo Tamura Yumi Aoyama Taiichi Kodaka Tomoo Itoh Takayuki Takahashi
article_metadata: 10.3960/jslrt.19025
article_metadata: J Clin Exp Hematop
article_metadata: 2019;59(4):196-201.
article_metadata: epstein-barr virus gamma heavy chain disease iatrogenic immunodeficiency-associated lymphoproliferative disorder infliximab methotrexate
article_metadata: CC BY-NC-SA
article_metadata: https://pubmed.ncbi.nlm.nih.gov/31866621/
article_metadata: Arthritis, Rheumatoid / drug therapy Arthritis, Rheumatoid / metabolism Arthritis, Rheumatoid / pathology Hematologic Neoplasms / chemically induced Hematologic Neoplasms / metabolism Hematologic Neoplasms / pathology Immunoglobulin gamma-Chains / metabolism Immunologic Deficiency Syndromes / chemically induced Immunologic Deficiency Syndromes / metabolism Immunologic Deficiency Syndromes / pathology Lymphoma, B-Cell / chemically induced Lymphoma, B-Cell / metabolism Lymphoma, B-Cell / pathology Methotrexate / adverse effects Neoplasm Proteins / metabolism
article_metadata: Arthritis, Rheumatoid / drug therapy Arthritis, Rheumatoid / metabolism Arthritis, Rheumatoid / pathology Hematologic Neoplasms / chemically induced Hematologic Neoplasms / metabolism Hematologic Neoplasms / pathology Immunoglobulin gamma-Chains / metabolism Immunologic Deficiency Syndromes / chemically induced Immunologic Deficiency Syndromes / metabolism Immunologic Deficiency Syndromes / pathology Lymphoma, B-Cell / chemically induced Lymphoma, B-Cell / metabolism Lymphoma, B-Cell / pathology Methotrexate / adverse effects Neoplasm Proteins / metabolism Case Reports Adalimumab / administration & dosage Adalimumab / adverse effects Crohn Disease / drug therapy Crohn Disease / metabolism Crohn Disease / pathology Fatal Outcome Female Humans Infliximab / administration & dosage Infliximab / adverse effects Methotrexate / administration & dosage Middle Aged Immunoglobulin gamma-Chains Neoplasm Proteins Infliximab Adalimumab Methotrexate
article_metadata: PMC6954170
article_metadata: 31866621
article_metadata: Gamma heavy chain disease (γ-HCD) as iatrogenic immunodeficiency- associated lymphoproliferative disorder: Possible emergent subtype of rheumatoid arthritis-associated γ-HCD
article_metadata: 2019