article_metadata: Shuier Zheng Fenglin Wang Jin Huang Yan Zhou Quanjun Yang Guowei Qian Chenliang Zhou Daliu Min Lele Song Zan Shen
article_metadata: 10.3389/fendo.2021.625226
article_metadata: Front Endocrinol (Lausanne)
article_metadata: 2021 Jun 18;12:625226.
article_metadata: chemotherapy immunotherapy osteosarcoma sequencing tumor mutational burden whole-exome sequencing
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/34220700/
article_metadata: Antibodies, Monoclonal, Humanized / therapeutic use Bone Neoplasms / drug therapy Mutation Osteosarcoma / drug therapy Ribs / pathology
article_metadata: Antibodies, Monoclonal, Humanized / therapeutic use Bone Neoplasms / drug therapy Mutation Osteosarcoma / drug therapy Ribs / pathology Case Reports Research Support, Non-U.S. Gov't Adult Antineoplastic Combined Chemotherapy Protocols / therapeutic use Bone Neoplasms / genetics Bone Neoplasms / pathology DNA Copy Number Variations Exome Sequencing Female Humans Osteosarcoma / genetics Osteosarcoma / pathology Remission Induction Treatment Outcome Antibodies, Monoclonal, Humanized pembrolizumab
article_metadata: PMC8249865
article_metadata: 34220700
article_metadata: Case Report: Sequential Chemotherapy and Immunotherapy Produce Sustained Response in Osteosarcoma With High Tumor Mutational Burden
article_metadata: 2021