article_metadata: Lujing Shao Tong Li Xinyan Jia Xinyu Zhang Qi Li Chunyan Dong
article_metadata: 10.1002/iub.70002
article_metadata: IUBMB Life
article_metadata: 2025 Feb;77(2):e70002.
article_metadata: egfr mutation nsclc osimertinib pemetrexed primary drug resistance
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/39907312/
article_metadata: Acrylamides / pharmacology Acrylamides / therapeutic use Aniline Compounds / pharmacology Aniline Compounds / therapeutic use Carcinoma, Non-Small-Cell Lung / drug therapy Carcinoma, Non-Small-Cell Lung / genetics Carcinoma, Non-Small-Cell Lung / pathology Drug Resistance, Neoplasm / genetics ErbB Receptors / antagonists & inhibitors ErbB Receptors / genetics Lung Neoplasms / drug therapy Lung Neoplasms / genetics Lung Neoplasms / pathology Mutation
article_metadata: Acrylamides / pharmacology Acrylamides / therapeutic use Aniline Compounds / pharmacology Aniline Compounds / therapeutic use Carcinoma, Non-Small-Cell Lung / drug therapy Carcinoma, Non-Small-Cell Lung / genetics Carcinoma, Non-Small-Cell Lung / pathology Drug Resistance, Neoplasm / genetics ErbB Receptors / antagonists & inhibitors ErbB Receptors / genetics Lung Neoplasms / drug therapy Lung Neoplasms / genetics Lung Neoplasms / pathology Mutation Case Reports Antineoplastic Agents / pharmacology Antineoplastic Agents / therapeutic use Female Humans Indoles Male Middle Aged Protein Kinase Inhibitors / pharmacology Protein Kinase Inhibitors / therapeutic use Pyrimidines Receptor, trkA / antagonists & inhibitors Receptor, trkA / genetics Receptor, trkA / metabolism Acrylamides osimertinib Aniline Compounds ErbB Receptors EGFR protein, human Protein Kinase Inhibitors Antineoplastic Agents Receptor, trkA Indoles Pyrimidines
article_metadata: PMC11796316
article_metadata: 39907312
article_metadata: Possible new mechanisms of primary drug resistance in NSCLC with EGFR mutation treated with Osimertinib
article_metadata: 2025