article_metadata: Frank Hoentjen Stephen B Hanauer Nanne K de Boer David T Rubin
article_metadata: 10.1007/s10620-011-1999-x
article_metadata: Dig Dis Sci
article_metadata: 2012 Jan;57(1):250-3.
article_metadata: CC BY-NC
article_metadata: https://pubmed.ncbi.nlm.nih.gov/22147254/
article_metadata: Allopurinol / therapeutic use Colitis, Ulcerative / drug therapy Colitis, Ulcerative / metabolism Guanine Nucleotides / metabolism Mercaptopurine / analogs & derivatives Mercaptopurine / therapeutic use Thionucleotides / metabolism
article_metadata: Allopurinol / therapeutic use Colitis, Ulcerative / drug therapy Colitis, Ulcerative / metabolism Guanine Nucleotides / metabolism Mercaptopurine / analogs & derivatives Mercaptopurine / therapeutic use Thionucleotides / metabolism Case Reports Antimetabolites / therapeutic use Colitis, Ulcerative / genetics Dose-Response Relationship, Drug Drug Therapy, Combination Humans Liver / enzymology Male Mercaptopurine / metabolism Methyltransferases / metabolism Steroids / therapeutic use Treatment Outcome Young Adult Antimetabolites Guanine Nucleotides Steroids Thionucleotides 6-thioguanylic acid Allopurinol 6-methylthiopurine Mercaptopurine Methyltransferases thiopurine methyltransferase
article_metadata: PMC3253335
article_metadata: 22147254
article_metadata: Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction
article_metadata: 2012