article_metadata: Annette Arndt Christian Neumann Armin Riecke Arthur Bauer Matthias Müller Manuela Wölfle-Guter Michael Grunert Hauke Busch Axel Künstner Nikolas von Bubnoff Stephanie Fliedner Dina Greinert Jasmin Osius Kumar Nagarathinam Konrad Steinestel Sivahari Prasad Gorantla Niklas Gebauer Hanno M Witte
article_metadata: 10.1093/oncolo/oyae143
article_metadata: Oncologist
article_metadata: 2025 Jan 17;30(1):oyae143.
article_metadata: alk inhibitors alk translocations nsclc functional validation molecular profiling
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/38960389/
article_metadata: Adenocarcinoma of Lung / drug therapy Adenocarcinoma of Lung / genetics Adenocarcinoma of Lung / pathology Anaplastic Lymphoma Kinase / genetics Crizotinib / pharmacology Crizotinib / therapeutic use Drug Resistance, Neoplasm / genetics Lung Neoplasms / drug therapy Lung Neoplasms / genetics Lung Neoplasms / pathology Pyrazoles / pharmacology Pyrazoles / therapeutic use
article_metadata: Adenocarcinoma of Lung / drug therapy Adenocarcinoma of Lung / genetics Adenocarcinoma of Lung / pathology Anaplastic Lymphoma Kinase / genetics Crizotinib / pharmacology Crizotinib / therapeutic use Drug Resistance, Neoplasm / genetics Lung Neoplasms / drug therapy Lung Neoplasms / genetics Lung Neoplasms / pathology Pyrazoles / pharmacology Pyrazoles / therapeutic use Case Reports Adenocarcinoma / drug therapy Adenocarcinoma / genetics Adenocarcinoma / pathology Aminopyridines / pharmacology Aminopyridines / therapeutic use Female Humans Lactams / therapeutic use Lactams, Macrocyclic / pharmacology Lactams, Macrocyclic / therapeutic use Male Middle Aged Mutation Mutation, Missense Oncogene Proteins, Fusion / genetics Organophosphorus Compounds / pharmacology Organophosphorus Compounds / therapeutic use Protein Kinase Inhibitors / pharmacology Protein Kinase Inhibitors / therapeutic use Pyridines / pharmacology Pyridines / therapeutic use Pyrimidines Receptor Protein-Tyrosine Kinases / genetics Anaplastic Lymphoma Kinase Crizotinib ALK protein, human Pyrazoles Protein Kinase Inhibitors lorlatinib brigatinib Aminopyridines Organophosphorus Compounds Lactams Lactams, Macrocyclic Pyridines Receptor Protein-Tyrosine Kinases Oncogene Proteins, Fusion EML4-ALK fusion protein, human Pyrimidines
article_metadata: PMC11783293
article_metadata: 38960389
article_metadata: Molecular tumor board: molecularly adjusted therapy upon identification and functional validation of a novel ALK resistance mutation in a case of lung adenocarcinoma
article_metadata: 2025