article_metadata: Thomas Parigger Stephan Drothler Christian Scherhäufl Franz Josef Gassner Maria Schubert Markus Steiner Jan Philip Höpner Alexandra Hödlmoser Lena Schultheis Aryunni Abu Bakar Daniel Neureiter Lisa Pleyer Alexander Egle Richard Greil Roland Geisberger Nadja Zaborsky
article_metadata: 10.1159/000537791
article_metadata: Acta Haematol
article_metadata: 2024;147(5):604-611.
article_metadata: chronic lymphocytic leukemia ibrutinib mutational analysis resistance mechanism transcriptome (rna-seq) mtor
article_metadata: CC BY-NC
article_metadata: https://pubmed.ncbi.nlm.nih.gov/38402867/
article_metadata: Adenine / analogs & derivatives Agammaglobulinaemia Tyrosine Kinase / antagonists & inhibitors Agammaglobulinaemia Tyrosine Kinase / genetics Agammaglobulinaemia Tyrosine Kinase / metabolism Drug Resistance, Neoplasm Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy Leukemia, Lymphocytic, Chronic, B-Cell / genetics Leukemia, Lymphocytic, Chronic, B-Cell / metabolism Piperidines / therapeutic use Protein Kinase Inhibitors / pharmacology Protein Kinase Inhibitors / therapeutic use Signal Transduction / drug effects TOR Serine-Threonine Kinases / antagonists & inhibitors TOR Serine-Threonine Kinases / metabolism
article_metadata: Adenine / analogs & derivatives Agammaglobulinaemia Tyrosine Kinase / antagonists & inhibitors Agammaglobulinaemia Tyrosine Kinase / genetics Agammaglobulinaemia Tyrosine Kinase / metabolism Drug Resistance, Neoplasm Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy Leukemia, Lymphocytic, Chronic, B-Cell / genetics Leukemia, Lymphocytic, Chronic, B-Cell / metabolism Piperidines / therapeutic use Protein Kinase Inhibitors / pharmacology Protein Kinase Inhibitors / therapeutic use Signal Transduction / drug effects TOR Serine-Threonine Kinases / antagonists & inhibitors TOR Serine-Threonine Kinases / metabolism Case Reports Review Humans Male Pyrazoles / pharmacology Pyrazoles / therapeutic use Pyrimidines / therapeutic use Agammaglobulinaemia Tyrosine Kinase ibrutinib TOR Serine-Threonine Kinases Adenine Piperidines BTK protein, human MTOR protein, human Protein Kinase Inhibitors Pyrimidines Pyrazoles
article_metadata: PMC11441378
article_metadata: 38402867
article_metadata: Oncogenic MTOR Signaling Axis Compensates BTK Inhibition in a Chronic Lymphocytic Leukemia Patient with Richter Transformation: A Case Report and Review of the Literature
article_metadata: 2024