article_metadata: Yanghui Ye Song Zheng
article_metadata: 10.3389/fimmu.2021.785400
article_metadata: Front Immunol
article_metadata: 2021 Nov 22;12:785400.
article_metadata: smad4 tsc2 chemotherapy immunotherapy next generation sequencing (ngs) pancreatic cancer
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/34880877/
article_metadata: Antibodies, Monoclonal, Humanized / therapeutic use Antineoplastic Combined Chemotherapy Protocols / pharmacology Carcinoma, Pancreatic Ductal / drug therapy Oxonic Acid / therapeutic use Pancreatic Neoplasms / drug therapy Tegafur / therapeutic use
article_metadata: Antibodies, Monoclonal, Humanized / therapeutic use Antineoplastic Combined Chemotherapy Protocols / pharmacology Carcinoma, Pancreatic Ductal / drug therapy Oxonic Acid / therapeutic use Pancreatic Neoplasms / drug therapy Tegafur / therapeutic use Case Reports Research Support, Non-U.S. Gov't Antibodies, Monoclonal, Humanized / pharmacology Antineoplastic Combined Chemotherapy Protocols / therapeutic use Carcinoma, Pancreatic Ductal / diagnosis Carcinoma, Pancreatic Ductal / genetics Carcinoma, Pancreatic Ductal / immunology DNA Mutational Analysis Drug Combinations Drug Resistance, Neoplasm Fluorouracil / pharmacology Fluorouracil / therapeutic use High-Throughput Nucleotide Sequencing Humans Irinotecan / pharmacology Irinotecan / therapeutic use Leucovorin / pharmacology Leucovorin / therapeutic use Male Middle Aged Mutation Neoplasm Staging Oxaliplatin / pharmacology Oxaliplatin / therapeutic use Oxonic Acid / pharmacology Pancreatic Neoplasms / diagnosis Pancreatic Neoplasms / genetics Pancreatic Neoplasms / immunology Prognosis Programmed Cell Death 1 Receptor / antagonists & inhibitors Response Evaluation Criteria in Solid Tumors Smad4 Protein / genetics Tegafur / pharmacology Tuberous Sclerosis Complex 2 Protein / genetics Antibodies, Monoclonal, Humanized Drug Combinations PDCD1 protein, human Programmed Cell Death 1 Receptor SMAD4 protein, human Smad4 Protein TSC2 protein, human Tuberous Sclerosis Complex 2 Protein folfirinox Oxaliplatin S 1 (combination) Tegafur Oxonic Acid Irinotecan sintilimab Leucovorin Fluorouracil
article_metadata: PMC8645965
article_metadata: 34880877
article_metadata: Successful Immunotherapy for Pancreatic Cancer in a Patient With TSC2 and SMAD4 Mutations: A Case Report
article_metadata: 2021