article_metadata: J G Maring A B P van Kuilenburg J Haasjes H Piersma H J M Groen D R A Uges A H Van Gennip E G E De Vries
article_metadata: 10.1038/sj.bjc.6600208
article_metadata: Br J Cancer
article_metadata: 2002 Apr 8;86(7):1028-33.
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/11953843/
article_metadata: Antimetabolites, Antineoplastic / adverse effects Antimetabolites, Antineoplastic / pharmacokinetics DNA, Neoplasm / genetics Fluorouracil / adverse effects Fluorouracil / pharmacokinetics Oxidoreductases / pharmacology Point Mutation
article_metadata: Antimetabolites, Antineoplastic / adverse effects Antimetabolites, Antineoplastic / pharmacokinetics DNA, Neoplasm / genetics Fluorouracil / adverse effects Fluorouracil / pharmacokinetics Oxidoreductases / pharmacology Point Mutation Case Reports Aged Alleles Chromatography, High Pressure Liquid Colorectal Neoplasms / drug therapy Dihydrouracil Dehydrogenase (NADP) Female Humans Leucovorin / administration & dosage Male Middle Aged Oxidoreductases / genetics Polymerase Chain Reaction Sequence Analysis, DNA Antimetabolites, Antineoplastic DNA, Neoplasm Oxidoreductases Dihydrouracil Dehydrogenase (NADP) Leucovorin Fluorouracil
article_metadata: PMC2364178
article_metadata: 11953843
article_metadata: Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene
article_metadata: 2002