article_metadata: Sara Cherradi Salomé Roux Marie Dupuy Séverine Tabone-Eglinger Edouard Tuaillon Marianne Ziol Eric Assenat Hong Tuan Duong
article_metadata: 10.1038/s41598-024-84304-4
article_metadata: Sci Rep
article_metadata: 2025 Jan 7;15(1):1179.
article_metadata: hepatocellular carcinoma patient-centric spheroid model prediction of clinical outcomes targeted therapy tyrosine kinase inhibitors
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/39774014/
article_metadata: Carcinoma, Hepatocellular / drug therapy Carcinoma, Hepatocellular / pathology Liver Neoplasms / drug therapy Liver Neoplasms / pathology Protein Kinase Inhibitors / pharmacology Protein Kinase Inhibitors / therapeutic use Tumor Microenvironment / drug effects
article_metadata: Carcinoma, Hepatocellular / drug therapy Carcinoma, Hepatocellular / pathology Liver Neoplasms / drug therapy Liver Neoplasms / pathology Protein Kinase Inhibitors / pharmacology Protein Kinase Inhibitors / therapeutic use Tumor Microenvironment / drug effects Anilides / pharmacology Anilides / therapeutic use Antineoplastic Agents / pharmacology Antineoplastic Agents / therapeutic use Cell Line, Tumor Coculture Techniques Female Hep G2 Cells Humans Male Models, Biological Phenotype Phenylurea Compounds / pharmacology Phenylurea Compounds / therapeutic use Pyridines / pharmacology Pyridines / therapeutic use Quinolines / pharmacology Quinolines / therapeutic use Sorafenib / pharmacology Sorafenib / therapeutic use Spheroids, Cellular / drug effects Spheroids, Cellular / pathology Protein Kinase Inhibitors Sorafenib Antineoplastic Agents Phenylurea Compounds Pyridines Quinolines cabozantinib lenvatinib Anilides
article_metadata: PMC11706984
article_metadata: 39774014
article_metadata: Modelling hepatocellular carcinoma microenvironment phenotype to evaluate drug efficacy
article_metadata: 2025