article_metadata: Yanjie Xu Qin Li Jiemin Zhao Xuefeng Ni Ping Li Wenwei Hu
article_metadata: 10.3389/fimmu.2022.1064488
article_metadata: Front Immunol
article_metadata: 2022 Nov 28;13:1064488.
article_metadata: lynch syndrome msh2 pd-1 inhibitors colorectal cancer germline mutation
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/36518767/
article_metadata: Adenocarcinoma / drug therapy Adenocarcinoma / genetics Colonic Neoplasms / drug therapy Colonic Neoplasms / genetics Colorectal Neoplasms, Hereditary Nonpolyposis / drug therapy Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
article_metadata: Adenocarcinoma / drug therapy Adenocarcinoma / genetics Colonic Neoplasms / drug therapy Colonic Neoplasms / genetics Colorectal Neoplasms, Hereditary Nonpolyposis / drug therapy Colorectal Neoplasms, Hereditary Nonpolyposis / genetics Case Reports Research Support, Non-U.S. Gov't Adult Germ Cells Germ-Line Mutation Humans Liver / pathology Male MutS Homolog 2 Protein / genetics Mutation MutS Homolog 2 Protein pembrolizumab MSH2 protein, human
article_metadata: PMC9742472
article_metadata: 36518767
article_metadata: Case report: Complete response to pembrolizumab in a liver metastatic colon adenocarcinoma patient with a novel likely pathogenic germline MSH2 mutation
article_metadata: 2022