article_metadata: Qun Zhang Jing Hu Yaping Zhang Li Li Ting Wang Xiaoping Qian
article_metadata: 10.3389/fimmu.2022.953421
article_metadata: Front Immunol
article_metadata: 2022 Aug 5;13:953421.
article_metadata: anti-pd1 therapy colorectal cancer lynch syndrome microsatellite instability-high resistance
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/35990637/
article_metadata: Colorectal Neoplasms, Hereditary Nonpolyposis / drug therapy Colorectal Neoplasms, Hereditary Nonpolyposis / genetics Microsatellite Instability
article_metadata: Colorectal Neoplasms, Hereditary Nonpolyposis / drug therapy Colorectal Neoplasms, Hereditary Nonpolyposis / genetics Microsatellite Instability Case Reports Research Support, Non-U.S. Gov't Germ-Line Mutation Humans Immunotherapy MutS Homolog 2 Protein / genetics MSH2 protein, human MutS Homolog 2 Protein
article_metadata: PMC9389357
article_metadata: 35990637
article_metadata: Case report: A colorectal cancer patient with microsatellite instability-high and MSH2 germline mutation failed to respond to anti-PD-1 immunotherapy
article_metadata: 2022