article_metadata: Jia Hu Baoshi Zhang Fangfang Yao Yan Fu Dianjun Chen Donghui Li Nan Du Analyn Lizaso Jinlei Song Lu Zhang Xiaosong Li
article_metadata: 10.1177/1753466620935770
article_metadata: Ther Adv Respir Dis
article_metadata: 2020 Jan-Dec;14:1753466620935770.
article_metadata: alk mutations lorlatinib resistance mechanism malignant pleural mesothelioma
article_metadata: CC BY-NC
article_metadata: https://pubmed.ncbi.nlm.nih.gov/32600123/
article_metadata: Anaplastic Lymphoma Kinase / genetics Antineoplastic Agents / therapeutic use Biomarkers, Tumor / genetics Drug Resistance, Neoplasm / genetics Gene Rearrangement Lactams, Macrocyclic / therapeutic use Mesothelioma, Malignant / drug therapy Mutation Oncogene Proteins, Fusion / genetics Pleural Neoplasms / drug therapy Protein Kinase Inhibitors / therapeutic use
article_metadata: Anaplastic Lymphoma Kinase / genetics Antineoplastic Agents / therapeutic use Biomarkers, Tumor / genetics Drug Resistance, Neoplasm / genetics Gene Rearrangement Lactams, Macrocyclic / therapeutic use Mesothelioma, Malignant / drug therapy Mutation Oncogene Proteins, Fusion / genetics Pleural Neoplasms / drug therapy Protein Kinase Inhibitors / therapeutic use Case Reports Adult Aminopyridines Anaplastic Lymphoma Kinase / antagonists & inhibitors Biomarkers, Tumor / antagonists & inhibitors Carbazoles / therapeutic use Humans Lactams Male Mesothelioma, Malignant / enzymology Mesothelioma, Malignant / genetics Mesothelioma, Malignant / pathology Piperidines / therapeutic use Pleural Neoplasms / enzymology Pleural Neoplasms / genetics Pleural Neoplasms / pathology Pyrazoles Treatment Outcome Aminopyridines Antineoplastic Agents Biomarkers, Tumor Carbazoles EML4-ALK fusion protein, human Lactams Lactams, Macrocyclic Oncogene Proteins, Fusion Piperidines Protein Kinase Inhibitors Pyrazoles ALK protein, human Anaplastic Lymphoma Kinase alectinib lorlatinib
article_metadata: PMC7328355
article_metadata: 32600123
article_metadata: Acquired multiple mutations ALK I1171N, L1196M and G1202R mediate lorlatinib resistance in EML4-ALK-rearranged malignant pleural mesothelioma: a case report
article_metadata: 2020