article_metadata: Ragna S Boerma Kees P Braun Marcel P H van den Broek Frederique M C van Berkestijn Marielle E Swinkels Eveline O Hagebeuk Dick Lindhout Marjan van Kempen Maartje Boon Joost Nicolai Carolien G de Kovel Eva H Brilstra Bobby P C Koeleman
article_metadata: 10.1007/s13311-015-0372-8
article_metadata: Neurotherapeutics
article_metadata: 2016 Jan;13(1):192-7.
article_metadata: scn8a epileptic encephalopathy phenytoin sodium channel blockers
article_metadata: CC BY
article_metadata: https://pubmed.ncbi.nlm.nih.gov/26252990/
article_metadata: Anticonvulsants / therapeutic use Epilepsy / genetics NAV1.6 Voltage-Gated Sodium Channel / genetics Phenytoin / therapeutic use
article_metadata: Anticonvulsants / therapeutic use Epilepsy / genetics NAV1.6 Voltage-Gated Sodium Channel / genetics Phenytoin / therapeutic use Case Reports Research Support, Non-U.S. Gov't Child Child, Preschool Epilepsy / drug therapy Female Humans Male Mutation, Missense / genetics NAV1.6 Voltage-Gated Sodium Channel / drug effects Treatment Outcome Anticonvulsants NAV1.6 Voltage-Gated Sodium Channel SCN8A protein, human Phenytoin
article_metadata: PMC4720675
article_metadata: 26252990
article_metadata: Remarkable Phenytoin Sensitivity in 4 Children with SCN8A-related Epilepsy: A Molecular Neuropharmacological Approach
article_metadata: 2016