case_images: PMC11424398_01
case_images: Electroencephalography of patient 1 showed generalized slowing and irregular epileptic discharges.
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case_images: PMC11424398_01_fped-12-1434209-g001.jpg
case_images: F1
case_images: Long-range EEG showed multifocal epileptiform discharges (Figure 1), with no abnormality in the auditory-evoked potential or visual-evoked examination, suggesting possible visual cortex lesions.
case_images: Axial and sagittal T2-weighted MRI of patient 1 showed diffuse high signal intensity within the white matter of the bilateral cerebral hemispheres.
case_images: fped-12-1434209-g002.jpg
case_images: PMC11424398_01_fped-12-1434209-g002.jpg
case_images: F2
case_images: Brain MRI showed that the white matter in the bilateral cerebral hemispheres was scattered in abnormal signal foci (Figure 2), these foci presented as hypointense on T1-weighted images and hyperintense on both T2-weighted and fluid-attenuated inversion recovery (FLAIR) sequences, diffusion tensor imaging (DTI) showed discontinuity of white matter fibers in the cingulate tract and corpus callosum bilaterally, and MRS showed the decreased ratio of choline to creatinine in the area of interest.
case_images: PMC11424398_02
case_images: Electroencephalography of patient 2 showed generalized slowing and multifocal epileptic discharges.
case_images: fped-12-1434209-g003.jpg
case_images: PMC11424398_02_fped-12-1434209-g003.jpg
case_images: F3
case_images: Her EEG showed abnormalities with a slow background, multifocal epileptiform discharges, and dozens of isolated or cluster seizures (Figure 3).
case_images: Axial and sagittal T2-weighted MRI of patient 2 showed diffuse high signal intensity within the bilateral white matter of the frontal, parietal, occipital lobes, and periventricular areas. MRI, magnetic resonance imaging.
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case_images: PMC11424398_02_fped-12-1434209-g004.jpg
case_images: F4
case_images: Craniocerebral MRI showed abnormal signal shadows in the frontal, parietal, occipital, and ventricular void areas bilaterally (Figure 4), these areas also appeared hypointense on T1-weighted images and hyperintense on both T2-weighted and FLAIR sequences.