case_images: PMC10859146_01
case_images: MRI of the brain in coronal and sagittal views (Panels A and B, respectively), with red arrows indicating the lesion at the right anterior temporal pole. MRI: magnetic resonance imaging
case_images: cureus-0016-00000052173-i01.jpg
case_images: PMC10859146_01_cureus-0016-00000052173-i01.jpg
case_images: FIG1
case_images: One month after the initial diagnosis, the patient presented to the emergency department with neurological symptoms, and magnetic resonance imaging (MRI) of the brain showed a spherical lesion near the gray-white matter differentiation of the right anterior temporal pole (Figure 1).
case_images: Low and medium power views show sheets of atypical, pleomorphic neoplastic cells in a background of mixed inflammatory cells (Panels A and B, 4x and 10x, respectively). High-power views showing the typical Reed-Sternberg cells (Panels C and D, 20x and 40x, respectively)
case_images: cureus-0016-00000052173-i02.jpg
case_images: PMC10859146_01_cureus-0016-00000052173-i02.jpg
case_images: FIG2
case_images: There are numerous large and atypical mononuclear cells similar to those seen in nodal, so-called syncytial Hodgkin cells (Figure 2).
case_images: CD15 immunostaining is diffusely positive in neoplastic Reed-Sternberg cells (Figure A, 20x). CD30 is weak or partial due to anti-CD30 treatment (Panel B. 20x). CD79a and PAX5 are diffusely positive in neoplastic cells (Panels C and D, 20x).. CD: cluster of differentiation, PAX5: paired box 5, B-cell lineage specific activator protein
case_images: cureus-0016-00000052173-i03.jpg
case_images: PMC10859146_01_cureus-0016-00000052173-i03.jpg
case_images: FIG3
case_images: The classic large Reed-Sternberg cells are positive for CD15, CD30 (partial and weak), CD79a, and PAX5 (Figure 3).