case_images: PMC11758865_01
case_images: Kidney HE, PAS, PASM and Masson staining. A HE Dyeing 100X; B PAS Dyeing 400X; C PASM Dyeing 400X; D Masson Dyeing 400X. The glomerular mesangial area has a powdery homogeneous deposition of unstructured material, which widens part of the glomerular mesangial area (A). The glomerular capsule wall and tubular basement membrane were not thickened (B). The segmental mesangial area of the glomerulus was widened, and the glomerular basement membrane showed segmental lash-like changes (C). No significant deposits of eosinophilic proteinaceous material were observed in the subepithelial, subendothelial, or mesangial areas of the glomeruli (D).
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case_images: PMC11758865_01_IMCRJ-18-139-g0001.jpg
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case_images: Renal pathology report (Guangzhou KingMed Center for Clinical Laboratory KB2006889): Congo red positive and oxidized Congo red positive, consistent with amyloidosis nephropathy, AL type (Figure 1); immunohistochemical examination of kidney tissue showed Lambda positive and Kappa negative (Figure 2).
case_images: The results of renal immunofluorescence and electron microscopy. (A) kappa (-), (B) lambda (+), (C) ALB (-); (D) mesangial area in diameter, (E)basement membrane and (F) arterioles. The lower row shows a large amount of fibroid material deposition in the renal tissue by ultramicroscopic electron microscopy, about 8-12 nm. Note: The upper row is the immunofluorescence staining method.
case_images: IMCRJ-18-139-g0002.jpg
case_images: PMC11758865_01_IMCRJ-18-139-g0002.jpg
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case_images: Renal pathology report (Guangzhou KingMed Center for Clinical Laboratory KB2006889): Congo red positive and oxidized Congo red positive, consistent with amyloidosis nephropathy, AL type (Figure 1); immunohistochemical examination of kidney tissue showed Lambda positive and Kappa negative (Figure 2).
case_images: Thyroid pathology H&E, Congo red staining and immunohistochemistry. (A and B) is immunohistochemistry, AA (-); (C and D) is HE staining, (C) 400X, (D) 200X; (E and F) is special staining, (E) is Congo red + polarized light, and (F)is Congo red. The thyroid interstitium shows pale red staining with unstructured material deposition and a large number of lymphocyte infiltration (A and B). Congo red staining shows amyloid as brick red (C) under a light microscope and apple-green birefringence (D) under a polarized light microscope. Immunohistochemistry reveals AA- (E and F).
case_images: IMCRJ-18-139-g0003.jpg
case_images: PMC11758865_01_IMCRJ-18-139-g0003.jpg
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case_images: Type AL (Figure 3) demonstrates that hypothyroidism is also caused by amyloidosis.