case_images: PMC11021691_01
case_images: (A-C) Fluid-attenuated inversion recovery (FLAIR) sequences in axial plane show progression of hyperintensities in basal ganglia [(A) 08/2020; (B) 10/2020; (C) 02/2021].
case_images: fneur-15-1365199-g0001.jpg
case_images: PMC11021691_01_fneur-15-1365199-g0001.jpg
case_images: F1
case_images: Four days later, non-contrast head MRI showed a slight bilateral striatum hyperintensity signal (HIS) on T1-weighted images, mixed bilateral striatum signal intensity on T2-weighted images with HIS on fluid-attenuated inversion recovery (FLAIR) images, without restriction of diffusion, suggesting petechial blood products corresponding to a T2* susceptibility artifact on SWI sequence (Figure 1A). Non-contrast head MRI showed mixed striatum signal intensity on T1-weighted images with hyperintensity in ventral putamen, hyperintensity on T2-weighted and FLAIR images, predominantly in bilateral putamen and caudate nuclei with a patchy restricted diffusion-weighted image signal suggesting necrosis (Figure 1B). At that time, head MRI scan (February 28, 2021) showed mixed striatum signal intensity and hyperintensity in the ventral putamen on T1-weighted, hyperintensity on T2-weighted and FLAIR MRI images, suggesting atrophy and gliosis of the striatum, without restriction of diffusion and without contrast enhancement on T1-weighted postcontrast images (Figure 1C).
case_images: Immunohistochemical staining of rat brain slices using human serum as source of the primary antibodies. Red arrows indicate positive staining reaction in different regions of the rat brain. P, patient; H, healthy control; NC, negative controle; Arc, arcuatus; CA1, cornu ammonis 1 region of hippocampus; Cbl, cerebellum; DG, dentate gyrus of hippocampus; Put, putamen; Ret, reticular formation of pons; SN, substantia nigra. Total magnification of individual image 200x, scale 200 micrometers.
case_images: fneur-15-1365199-g0002.jpg
case_images: PMC11021691_01_fneur-15-1365199-g0002.jpg
case_images: F2
case_images: As shown in Figure 2, rat brains reacted with the patient's serum in several regions (nucleus arcuatus, cornu ammonis 1 region of the hippocampus, cerebellum, dentate gyrus of the hippocampus, putamen, reticular formation of the pons and substantia nigra).