case_images: PMC10954778_01
case_images: Cranial MRI showed bilateral hippocampal atrophy with medial temporal lobe atrophy (MTA) of grade 2 (A, white arrow), and multiple ischemic white matter lesions with Fazekas scale of grade 1 (B, white arrow).
case_images: fnins-18-1343279-g001.jpg
case_images: PMC10954778_01_fnins-18-1343279-g001.jpg
case_images: fig1
case_images: 18F-FDG-PET/CT showed decreased glucose metabolism and brain atrophy in the bilateral parietal, temporal, and frontal lobes (A-D). 11C-PiB-PET/CT showed diffuse deposition of Abeta in the bilateral frontal, parietal, temporal, and occipital lobes, especially in posterior cingulate gyrus and precuneus (E-H).
case_images: fnins-18-1343279-g002.jpg
case_images: PMC10954778_01_fnins-18-1343279-g002.jpg
case_images: fig2
case_images: Whole exome sequencing revealed a C-to-T missense mutation of nucleotide 3,755 (c.3755C > T) in exon 25 of the ACE gene, resulting in the change of amino acid 1,252 from alanine to valine (p. Ala1252Val) (red arrow).
case_images: fnins-18-1343279-g003.jpg
case_images: PMC10954778_01_fnins-18-1343279-g003.jpg
case_images: fig3
case_images: ACE gene on chromosome 17q23, resulting in the change of amino acid 1,252 from alanine to valine (p. Ala1252Val) (rs762056936) (Figure 3).