case_images: PMC10622943_01
case_images: JCPyV-N: (A) Renal cortex with a minimal infiltrate, minimal interstitial fibrosis and tubular atrophy, and tubular epithelial cells with viral cytopathic effect (arrow) (H&E, 100X). (B) JCPyV cytopathic effect including glassy nuclear inclusions with chromatin margination (arrow) (H&E, 600X). (C) SV40 immunohistochemical stain of cytoplasmic inclusions (100X). (D) JCPyV ISH stain of cytoplasmic inclusions (100X).
case_images: fmed-10-1282827-g001.jpg
case_images: PMC10622943_01_fmed-10-1282827-g001.jpg
case_images: fig1
case_images: DNA PCR in blood was positive at 6,052 IU/mL. Due to positive SV40 staining in the setting of JCPyV viremia and the absence of BKPyV viremia, JCPyV DNA-specific ISH staining in paraffin-embedded kidney tissue was performed and showed positive staining in the nuclei of multiple tubular epithelial cells, supporting the diagnosis of JCPyV-N (Figure 1).
case_images: Timeline of clinical events, immunosuppression, JCPyV titer, and SCr trends.
case_images: fmed-10-1282827-g002.jpg
case_images: PMC10622943_01_fmed-10-1282827-g002.jpg
case_images: fig2
case_images: The timeline of events, immunosuppression, kidney function, and JCPyV titer trends are illustrated in Figure 2.