case_images: PMC11320414_01
case_images: Timeline of immunized myocarditis and immunized pneumonia treated with corticosteroid interventions.
case_images: fonc-14-1391698-g001.jpg
case_images: PMC11320414_01_fonc-14-1391698-g001.jpg
case_images: f1
case_images: Concurrently, he was administered zoledronic acid (q.4w. 4 mg) treatment (schedule as in  Figure 1 ).
case_images: ECG of the patient at the onset of chest tightness. Heart rate was 71 beats/min. PR 192ms, QRS 147ms, OT 439ms, QTc 477ms. electrical axis: -63 . The diagnosis: sinus rhythm, severe left deviation of the electrical axis, complete right bundle branch block, left anterior branch block, and ST-T changes.
case_images: fonc-14-1391698-g002.jpg
case_images: PMC11320414_01_fonc-14-1391698-g002.jpg
case_images: f2
case_images: The electrocardiogram showed sinus rhythm, severe left deviation of the heart's electrical axis, complete right bundle-branch block, left anterior branch block, and ST-T changes ( Figure 2 ).
case_images: The changes of various blood indexes over time during continuous irAEs in patients. (A) Changes in blood markers of myocardial injury. (B) Changes in markers of liver function injury impairment. (C) Changes in cytokine levels. Ultra-TNI, Ultrasensitive Troponin I; MYO, Myoglobin; CK-MB, Creatine Kinase Isoenzyme; AST, Aspartate Aminotransferase; ALT, Alanine aminotransferase; LDH, Lactate dehydrogenase; CK, Creatine kinase; IL-2, Interleukin 2; IL-4, Interleukin 4; IL-6, Interleukin 6; IL-10, Interleukin 10; TNF-alpha, Tumor Necrosis Factor; INF-gamma, Gamma-interferon.
case_images: fonc-14-1391698-g004.jpg
case_images: PMC11320414_01_fonc-14-1391698-g004.jpg
case_images: f4
case_images: A CT scan revealed that the inflammation in both lungs had partially resolved after four days ( Figures 3D1-D2 ) and nearly completely by the 17th day ( Figures 3F1-F2  and  Figure 4 ).