case_images: PMC6473054_01
case_images: Brain and spine MRI findings. The initial axial fluid-attenuated inversion recovery (A), axial T1-weighted gadolinium-enhanced (B), and axial diffusion weighted imaging (C) brain MRI showed bilateral irregular hyperintense lesions around the ventricles with enhancement on the right temporal lobe. (D) Sagittal T2-weighted cervical spine MRI showed hyperintensity longitudinally extending from the cervical to the thoracic cord. (F-H) Six months later, the follow-up axial T2-weighted brain MRI (F) and diffusion weighed imaging (H) showed a mass lesion in the right temporal lobe with homogenous enhancement on T1-weighted gadolinium-enhanced series (G); Sagittal T2-weighted cervical spine MRI showed regredient lesions in the cervical cord (E). (I,J) After the chemotherapy, the right temporal lesion on T1-weighted gadolinium-enhanced series (I) was significantly regredient and necrotic; No abnormal signal was displayed on diffusion weighted imaging (J). R indicates right and L indicates left.
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case_images: PMC6473054_01_fonc-09-00266-g0001.jpg
case_images: F1
case_images: Brain MRI revealed multifocal periventricular lesions with gadolinium enhancement in the left medial temporal lobe (Figures 1A-C). Spine MRI revealed longitudinally extensive abnormal signal extending from the cervical to the thoracic cord (Figure 1D). However, the 6-month follow-up brain MRI revealed an unexpected enhancing temporal mass with extensive perifocal edema (Figures 1F-H). Repeat spine MRI revealed decreasing lesions without contrast enhancement (Figure 1E). Repeat brain MRI showed necrosis of the original mass lesion, no new lesions were observed (Figures 1I,J).
case_images: Brain biopsy findings. Hematoxylin and eosin staining revealed diffusely distributed atypical lymphoid cells (A). Immunohistochemistry study revealed strong positive staining of the lymphoma cells for CD20 B cell marker (B), and the Ki-67 index was 70% (C). Magnification, x400 for all.
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case_images: F2
case_images: Histopathological findings of the specimen demonstrated DLBCL (Figure 2).
case_images: Whole-body PET/CT findings. PET/CT imagings showed abnormal hypermetabolic lesions in the left testicle (A) and in multiple abdominal and retroperitoneal lymph nodes (B).
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case_images: PMC6473054_01_fonc-09-00266-g0003.jpg
case_images: F3
case_images: Abnormal hypermetabolism was found in the left testicle and in multiple abdominal and retroperitoneal lymph nodes (Figure 3).