case_images: PMC9937683_01
case_images: Hyperkeratotic desquamating plaques over the (A) left fifth metatarsal, (B) right great toe, and (C) right fourth metatarsophalangeal joint.
case_images: cureus-0015-00000033937-i01.jpg
case_images: PMC9937683_01_cureus-0015-00000033937-i01.jpg
case_images: FIG1
case_images: On clinical examination, the patient had hyperkeratotic tender plaques with overlying superficial desquamation over the plantar surfaces of the right great toe, left fifth metatarsal, and bilateral fourth metatarsophalangeal joints (Figure 1A-1C).
case_images: HFSR (A) before and (B) after treatment with topical keratolytics, topical steroids, and brief cessation of axitinib.. HFSR: hand-foot skin reaction
case_images: cureus-0015-00000033937-i02.jpg
case_images: PMC9937683_01_cureus-0015-00000033937-i02.jpg
case_images: FIG2
case_images: Given the prompt improvement in pain and lesion size within one week of cessation (Figure 2A-2B), the patient was successfully able to restart axitinib at a decreased dose of 3 mg twice daily instead of 5 mg twice daily.