case_images: PMC5574659_01
case_images: MRI of case one (a) before imatinib (axial section) (b) before imatinib (coronal section) (c) after 3 months imatinib (d) after 6 months imatinib.
case_images: can-11-760fig1.jpg
case_images: PMC5574659_01_can-11-760fig1.jpg
case_images: figure1
case_images: Clinical oncologists started Imatinib (Gleevec ) at 400 mg daily dose for three months with good radiological response, the lesion downsized to 1.5 cm in maximum diameter (Figure 1).
case_images: Case one (a) white thickened patch at the site of the tumour (b) Resection of the residual lesion.
case_images: can-11-760fig2.jpg
case_images: PMC5574659_01_can-11-760fig2.jpg
case_images: figure2
case_images: The patient was positioned in the right lateral decubitus and wide local excision using TEO platform was done, followed by primary suturing with V-Loc  suture (Covidien, MA, USA) (Figure 2).
case_images: PMC5574659_02
case_images: MRI of case two (a) axial section showing large tumour in the left anterolateral wall of the anal canal (b) Coronal section showing no extraluminal extension (c) T1-weighted and (d) T2-weighted sagittal views showing the tumour relation to the posterior vaginal wall.
case_images: can-11-760fig3.jpg
case_images: PMC5574659_02_can-11-760fig3.jpg
case_images: figure3
case_images: Pelvic MRI reported intraluminal mass in the rectum 4.5 cm, infiltrating the left lateral rectal wall (Figure 3).
case_images: Resection of case two (a) dissection of friable tumour (b) tumour dissected completely from the left side with intact musculosa (c) cutting the remaining attachment with Harmonic scalpel.
case_images: can-11-760fig4.jpg
case_images: PMC5574659_02_can-11-760fig4.jpg
case_images: figure4
case_images: After complete resection, further separate safety margins from the edges and depth of the cavity were sent for histopathological examination (Figure 4).
case_images: Pathology specimens of case two (a) shows interlacing bundles of spindle cells (H&E staining, 100x) (b) shows interlacing bundles of spindle cells (H&E staining, 400x) (c) shows positive membranous reaction (CD117 immunostaining, 400x) (d) shows positive membranous reaction (DOG-1 immunostaining, 400x).
case_images: can-11-760fig5.jpg
case_images: PMC5574659_02_can-11-760fig5.jpg
case_images: figure5
case_images: Pathology revealed a low-risk GIST with microscopic infiltration of left margin confirmed by immunostain (Figure 5).