case_images: PMC11211873_01
case_images: Abdominal computed tomography. Before (a)-(c) and after (d)-(f) chemotherapy axial; yellow arrow, upper left mass.
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case_images: PMC11211873_01_j_biol-2022-0898-fig001.jpg
case_images: j_biol-2022-0898_fig_001
case_images: At admission, computed tomography scans of the chest and whole abdomen were performed, revealing increased T4 and T11 bone density, a compression fracture, splenomegaly, a mid-abdominal mass, and peripheral lymphadenomegaly (Figure 1a-c). The size of the enlarged abdominal cavity mass did not decrease significantly (Figure 1d-f).
case_images: Abdominal cavity mass biopsy: (a) Hematoxylin & eosin staining x1,000, (b) CD138-positive cells x1,000, (c) CD38-positive cells x1,000, (d) CD20-positive cells x1,000, (e) Kappa-positive cells x1,000, (f) Lambda-positive cells x1,000, (g) HHV-8-negative cells x1,000, (h) IgG 4-scattered positive cells (0-5 cells/HPF) x1,000, and (i) CD56-negative cells, x1,000.
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case_images: j_biol-2022-0898_fig_002
case_images: Immunohistological analysis revealed the following findings: plasma cells with CD38, CD138, CD19, Kappa and Lambda positivity, HHV8-negative, CD56-negative, IgG4-scattered positive (approximately 0-5 pcs/HPF), B lymphocytes with CD19 and CD20 positivity, T lymphocytes with CD3 and CD5 positivity, Cyclin D1-negative, and Ki-67 (+5-10%) (Figure 2).
case_images: Changes in indices pre- and post-chemotherapy. HGB, hemoglobin; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; Fbg, fibrinogen; IL-6, interleukin-6; RBC, red blood cell; TCP, thalidomide, cyclophosphamide, prednisolone.
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case_images: PMC11211873_01_j_biol-2022-0898-fig003.jpg
case_images: j_biol-2022-0898_fig_003
case_images: No reduction in C-reactive protein (CRP), ESR, fibrinogen (Fbg), and interleukin (IL)-6 levels were observed (Figure 3).