case_images: PMC10901572_01
case_images: (a) Left conjunctival chemosis. (b) Solid subconjunctival superior bulbar mass.
case_images: CRIOPM2024-2235819.001.jpg
case_images: PMC10901572_01_CRIOPM2024-2235819.001.jpg
case_images: fig1
case_images: With resolution of the chemosis, a solid subconjunctival mass was noted underlying the superior bulbar conjunctiva adherent to the globe (Figure 1).
case_images: Vertical OCT raster of the macula demonstrating retinal folds and dependent subretinal fluid from exudative retinal detachment.
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case_images: PMC10901572_01_CRIOPM2024-2235819.002.jpg
case_images: fig2
case_images: Vertical optical coherence tomography (OCT) raster of the macula demonstrated retinal folds and dependent subretinal fluid from exudative retinal detachment (Figure 2). 45-degree fluorescein angiography was performed and demonstrated diffuse pooling of due within the exudative retinal detachments.
case_images: Exudative retinal detachments and thickening of globe tissue seen on MRI orbits (T2 sequence).
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case_images: fig3
case_images: A FDG-PET scan showed moderate to intense metabolically active soft tissue thickening in the left globe, and an MRI of the brain showed exudative retinal detachments and thickening of the globe tissue (Figure 3).
case_images: Infiltrate of blast cells seen on cytospin from scleral biopsy. Photo taken on 40x high-power magnification.
case_images: CRIOPM2024-2235819.004.jpg
case_images: PMC10901572_01_CRIOPM2024-2235819.004.jpg
case_images: fig4
case_images: Cytospin from this subretinal fluid showed a significant blast cell infiltrate (Figure 4), and flow cytometry of the subconjunctival biopsy confirmed a prominent CD7+ and CD34+ monomorphic population which was the same myeloid population seen on her initial diagnosis (Figure 5), confirming the diagnosis of ocular relapsed AML.
case_images: Flow cytometry from subconjunctival biopsy, superior sclerotomy, left eye. The first 3 flow plots show the population of blast cells with CD34 (surface marker indicative of blast cells) with an aberrant CD7. This is the original population seen on the initial diagnosis of AML for the patient. The conjunctival biopsy demonstrated the same population with CD34- and CD7-positive blast cells.
case_images: CRIOPM2024-2235819.005.jpg
case_images: PMC10901572_01_CRIOPM2024-2235819.005.jpg
case_images: fig5
case_images: Cytospin from this subretinal fluid showed a significant blast cell infiltrate (Figure 4), and flow cytometry of the subconjunctival biopsy confirmed a prominent CD7+ and CD34+ monomorphic population which was the same myeloid population seen on her initial diagnosis (Figure 5), confirming the diagnosis of ocular relapsed AML.