case_images: PMC8655874_01
case_images: Serum creatine (blue line) and diuresis (red line) before and after tocilizumab administration in the described patient. A: Serum creatinine and diuresis at time of 50% cyclosporine dose reduction. B: Serum creatinine and diuresis at time of withdrawn cyclosporine administration. C: Serum creatinine and diuresis after 24-48 h of tocilizumab administration.
case_images: fmed-08-732792-g0001.jpg
case_images: PMC8655874_01_fmed-08-732792-g0001.jpg
case_images: F1
case_images: C-reactive protein was consistently declined to 1.6 mg/l with improvement of graft function (Figure 1). After 4 days from tocilizumab administration, physical examination revealed an improvement of the respiratory clinic with a stable oxygen saturation on the ventilator around 99%, respiratory rate of 29 breaths/min, and serum creatinine returned to baseline level (1.02 mg/ml) (Figure 1); a second X-ray was performed showing a reduction of the pulmonary opacities (Figure 2A, X-ray at hospital admission; Figure 2B, X-ray after tocilizumab administration).
case_images: (A) X-ray at hospital admission describing parenchymal thickening and a bilateral widespread pulmonary interstitial involvement. (B) Tocilizumab administration led to bilateral improvement with a decrease in the density and in the extension of lung thicknesses (X-ray).
case_images: fmed-08-732792-g0002.jpg
case_images: PMC8655874_01_fmed-08-732792-g0002.jpg
case_images: F2
case_images: After 4 days from tocilizumab administration, physical examination revealed an improvement of the respiratory clinic with a stable oxygen saturation on the ventilator around 99%, respiratory rate of 29 breaths/min, and serum creatinine returned to baseline level (1.02 mg/ml) (Figure 1); a second X-ray was performed showing a reduction of the pulmonary opacities (Figure 2A, X-ray at hospital admission; Figure 2B, X-ray after tocilizumab administration).