case_images: PMC11705498_01
case_images: A 0.7 x 0.5 cm2 purplish-red domed nodule located below the left mandibular angle.
case_images: CNR2-8-e70113-g001.jpg
case_images: PMC11705498_01_CNR2-8-e70113-g001.jpg
case_images: cnr270113-fig-0001
case_images: Upon examination, the patient had a 0.7 x 0.5 cm2, nontender, firm, purplish-red domed nodule below the left mandibular angle (Figure 1).
case_images: Histopathology demonstrates uniform, small, round cells with centrally located nuclei set within a slightly eosinophilic cytoplasm. Small vessels surrounded by glomus cells, with prominent vascular component, no nuclear atypia or atypical mitotic figure was observed (hematoxylin and eosin) (A; 10x; B; 40x).
case_images: CNR2-8-e70113-g003.jpg
case_images: PMC11705498_01_CNR2-8-e70113-g003.jpg
case_images: cnr270113-fig-0002
case_images: The stromal component exhibited mucoid and hyaline degeneration (Figure 2A,B).
case_images: Immunohistochemical staining indicated that the tumor cells were positive for vimentin (A; 20x), SMA (B; 20x), Syn (C; 20x), actin (D; 20x), desmin (E; 20x), CD34 (F; 20x), and negative for CgA (G; 20x). The Ki-67 (H; 20x) proliferative index is 1% in the glomus tumor.
case_images: CNR2-8-e70113-g002.jpg
case_images: PMC11705498_01_CNR2-8-e70113-g002.jpg
case_images: cnr270113-fig-0003
case_images: IHC staining further confirmed tumor's smooth muscle and mesenchymal origins, with positive for vimentin (Figure 3A), smooth muscle antibody (SMA, Figure 3B), synapsin (Syn, Figure 3C), actin (Figure 3D), desmin (Figure 3E), CD34 (vascular, Figure 3F), while negative for and chromogranin A (CgA, Figure 3G). The Ki-67 mitotic index labeled 1% of the tumor cells (Figure 3H).