case_images: PMC5312195_01
case_images: A. Patient's face (front view), showing lentigines,
  hypertelorism, and tongue protrusion. B. Patient's face
  (profile view), showing lentigines, hypertelorism, and tongue
  protrusion
case_images: abd-92-01-0127-gf01.jpg
case_images: PMC5312195_01_abd-92-01-0127-gf01.jpg
case_images: f1
case_images: A 12-year-old dark-skinned male patient was admitted at the dermatology service with the following characteristics: hypertelorism, macroglossia, lentigines, hypospadias, cryptorchidism, subaortic stenosis, growth retardation, and about 50% of his hearing compromised (Figure 1).
case_images: Intraoral photograph showing severe anterior open bite due to
  macroglossia
case_images: abd-92-01-0127-gf02.jpg
case_images: PMC5312195_01_abd-92-01-0127-gf02.jpg
case_images: f2
case_images: The patient had a severe anterior open bite (no contact of the upper and lower front teeth) due to macroglossia (Figure 2).