case_images: PMC3484813_01
case_images: Neoplastic cells growing in poorly defined glandular structures were seen at the periphery of the biopsy (H&E).
case_images: can-6-275fig1.jpg
case_images: PMC3484813_01_can-6-275fig1.jpg
case_images: figure1
case_images: A tru-cut biopsy of the breast lump confirmed that it was an invasive carcinoma (Figure 1), the tissue was positive for hormonal estrogen and progesterone receptors (50%), HER-2 expression was complete and intense in 70% of neoplastic cells (3+), and Ki-67 expression was positive in 20% off cells (Figure 2). A bone scan indicated secondary bone lesions (sternum, left humeral head,
case_images: Neoplastic cells were positive for ER, PgR and HER2/neu and are characterized by a high proliferative fraction.
case_images: can-6-275fig2.jpg
case_images: PMC3484813_01_can-6-275fig2.jpg
case_images: figure2
case_images: A tru-cut biopsy of the breast lump confirmed that it was an invasive carcinoma (Figure 1), the tissue was positive for hormonal estrogen and progesterone receptors (50%), HER-2 expression was complete and intense in 70% of neoplastic cells (3+), and Ki-67 expression was positive in 20% off cells (Figure 2). A bone scan indicated secondary bone lesions (sternum, left humeral head,
case_images: Bone scan before oral Cyclophosphamide and Methotrexate chemotherapy.
case_images: can-6-275fig3.jpg
case_images: PMC3484813_01_can-6-275fig3.jpg
case_images: figure3
case_images: In May 2008, the breast site had progressed, and a new lesion was detected on the skull (Figure 3).
case_images: Bone scan after 42 months of oral Cyclophosphamide and Methotrexate chemotherapy.
case_images: can-6-275fig4.jpg
case_images: PMC3484813_01_can-6-275fig4.jpg
case_images: figure4
case_images: The last bone scan showed a pathologic capitation only on the skull and sternum (Figure 4).