case_images: PMC3969642_01
case_images: (a) Hydrocele sac wall. (b) Hydrocele sac wall diffusely infiltrated by histiocytes having clear to multivacuolated cytoplasm (H and E, x100). (c) Large cells with moderate nuclear pleomorphism and clear/ vacuolated cytoplasm (H and E, x400)
case_images: JLP-6-43-g001.jpg
case_images: PMC3969642_01_JLP-6-43-g001.jpg
case_images: F1
case_images: Partially excised left hydrocele sac was received in multiple bits for histopathological examination [Figure 1a]. Histopathological examination showed fibrocollagenous wall of hydrocele sac that was diffusely infiltrated by large cells having clear to multivacuolated cytoplasm [Figure 1b]. Nuclei in few cells were pushed to the periphery with little distortion [Figure 1c].
case_images: (a) Mucicarmin-negative cytoplasm of the histiocytes (Mucicarmin, x400). (b-d) Negative epithelial membrane antigen, pan-Cytokeratin and calretinin (immunohostochemistry, x400)
case_images: JLP-6-43-g002.jpg
case_images: PMC3969642_01_JLP-6-43-g002.jpg
case_images: F2
case_images: Cytoplasm of the cells did not stain with Mucicarmin stain [Figure 2a]. In immunohistochemistry (IHC) staining, cells were negative with epithelial membrane antigen (EMA), pan-Cytokeratin and calretinin [Figure 2b-d].
case_images: Histiocytes show (a) strong diffuse cytoplasmic positivity with CD 68 (IHC, x100). (b) Nonspecific staining with carcinoembryonic antigen (IHC, x400). (c-e) Negative staining with cytokeratin 7, cytokeratin 20 and prostate-specific antigen (IHC, x400)
case_images: JLP-6-43-g003.jpg
case_images: PMC3969642_01_JLP-6-43-g003.jpg
case_images: F3
case_images: CD68 [Figure 3a]. Carcinoembryonic antigen (CEA) showed nonspecific staining [Figure 3b] and cytokeratin 7 (CK7), cytokeratin 20 (CK20) and prostate-specific antigen (PSA) were negative [Figure 3c-e].