case_images: PMC6537058_01
case_images: Patient developed non-pruritic painful rash on both arms after 13 months of
  combination vemurafenib and cobimetinib. Skin punch biopsies with
  haematoxylin and eosin stain at (a) 20x magnification and (b) 100x
  magnification: granulomatous dermatitis with multiple non-caseating
  granulomas in superficial and deep dermis.
case_images: 10.1177_2050313X19847358-fig1.jpg
case_images: PMC6537058_01_10.1177_2050313X19847358-fig1.jpg
case_images: fig1-2050313X19847358
case_images: Skin biopsy showed a vemurafenib-induced granulomatous dermatitis with multiple non-caseating granulomas in the superficial and deep dermis (Figure 1(a) and (b)).
case_images: (a) At 26 months of combination vemurafenib and cobimetinib, the patient
  developed non-pruritic and non-painful lesions on his legs. Skin punch
  biopsies with haematoxylin and eosin stain at (b) 20x magnification and (c)
  100x magnification: neutrophilic lobular panniculitis with vasculitis known
  as erythema induratum.
case_images: 10.1177_2050313X19847358-fig2.jpg
case_images: PMC6537058_01_10.1177_2050313X19847358-fig2.jpg
case_images: fig2-2050313X19847358
case_images: He subsequently developed four large non-painful, non-pruritic, purple-coloured lesions on his legs (Figure 2(a)) in May 2016. Biopsies of these lesions revealed neutrophilic lobular panniculitis with vasculitis, known as erythema induratum (Figure 2(b) and (c)).