case_images: PMC11243764_01
case_images: DBS-induced mood shift. Activation of contact 1 on the left side elicited immediate euphoric behavior, including pacing, squatting, and grabbing the examiner. Returning to baseline settings resolved the symptoms.. DBS: Deep brain stimulation.
case_images: .jpg
case_images: PMC11243764_01_.jpg
case_images: V1
case_images: Imaging showed that both DBS leads were well placed in the dorsolateral STN (Figure 1A). The MNI 2009b nonlinear asymmetric atlas was nonlinearly registered to overlay bilateral segmentations of the STN and respective subregions (motor, associative, and limbic) from the DISTAL atlas (Figure 1B). The VTA models indicated that compared to baseline, stimulation that induced elevated mood spread further into the left ventromedial STN (Figure 1C). This spread of stimulation resulted in higher VTA overlap with the motor, associative, and limbic subregions of the left STN. However, the levels of VTA overlap in the left STN were similar to those of the right STN, which minimally impacted mood (Figure 1D).