case_images: PMC6005277_01
case_images: PMC6005277_02
case_images: Inflammation in and about the eye in a Doberman treated with G6PD inhibition for a cytologically verified soft tissue sarcoma in her right ischium. Inflammation such as this is a feature of the human autosomal recessive disease mevalonate kinase deficiency, caused by NALP3 inflammasome-mediated IL1beta secretion.
case_images: CRIVEM2017-4275305.001.jpg
case_images: PMC6005277_02_CRIVEM2017-4275305.001.jpg
case_images: fig1
case_images: DHEA and 0.1 mg/kg/day ubiquinone. During treatment, an acute inflammatory reaction involving the eyes was noted (Figure 1).
case_images: Interdigital inflammatory skin lesion closely resembling those observed in MKD patients. This patient had numerous such lesions on her extremities, trunk, and foot pads.
case_images: CRIVEM2017-4275305.002.jpg
case_images: PMC6005277_02_CRIVEM2017-4275305.002.jpg
case_images: fig2
case_images: This was followed by multiple inflammatory cutaneous lesions on the legs, foot pads, and trunk (Figure 2).
case_images: Radiographs of a dog with soft tissue sarcoma before and after treatment with high dose DHEA. Note the right ischial soft tissue sarcoma (a) which completely resolved as a result of treatment (b).
case_images: CRIVEM2017-4275305.003.jpg
case_images: PMC6005277_02_CRIVEM2017-4275305.003.jpg
case_images: fig3
case_images: Of note, posttreatment radiographs showed complete tumor regression (Figure 3).