case_images: PMC6791282_01
case_images: (a) Morphological features (haematoxylin and eosin x100; insert x400) and (b) CD30 expression (x100) of the skin lesion; (c) intraoperatory picture of gingival neoformation and (d) its morphologic features (Giemsa stain, x200); immunohistochemical expression of (e) CD20 (x400) and (f) Ki67 (x400) in DLBCL.
case_images: CRIHEM2019-8959145.001.jpg
case_images: PMC6791282_01_CRIHEM2019-8959145.001.jpg
case_images: fig1
case_images: The histological examination of the removed lesion showed a proliferation of medium/large sized lymphoid cells infiltrating dermis and subcutaneous tissue, without epidermotropism or ulceration and absence of inflammatory background (Figure 1(a)). A strong and diffuse CD30 positivity was observed (Figure 1(b)), while B-cell markers were negative as well as EMA, Perforin, Alkc, HHV8, and CD56. Few months later, this lesion had reached 3 cm in diameter (Figure 1(c)) and an incisional surgical biopsy was performed (February 2014). The gingival tissue was diffusely infiltrated by large lymphoid cells with a prevalent immunoblastic morphology (Figure 1(d)), expressing CD20 (Figure 1(e)), BCL6, and IRF4 while CD10, CD3, and CD30 were negative. The proliferation index was high (90% Ki67+ cells) (Figure 1(f)).