case_images: PMC10977438_01
case_images: Visual evoked potentials (VEPs) performed by checkerboard pattern reversal stimuli system with 30' (A) and 15' (B) checks in our patient. All VEPs were recorded after monocular stimulation using Ag/AgCl skin electrodes placed accordingly to the 10-20 international system in Oz (active electrode) and Cz (reference electrode). Two series of 100 artifact-free responses were averaged for each check and each eye. The peak latency of the major positive wave (P100) was measured to the nearest millisecond. With 30' checks the latency was 132 and 135 ms for right eye (RE) and left eye (LE) stimulation, respectively (upper normal limit: 118 ms), while the amplitude was 1.4muV and 0.8muV for right eye (RE) and left eye (LE) stimulation respectively (lower normal limit: 3muV). Cortical responses were non-recordable using the 15' checks. Full-field electroretinogram (ERG) was recorded using flash stimulation of the LE (C) and RE (D) in mesopic condition by a Ag/AgCl a skin electrode placed over the ipsilateral ear lobe and reference electrode placed over the skin of the lower eyelid of the stimulated eye. Flash-induced VEPs (lower traces) were recorded by occipital surface electrode positioned as above said. III and IV waves were recordable after stimulation of both eyes.
case_images: adr-8-adr230176-g001.jpg
case_images: PMC10977438_01_adr-8-adr230176-g001.jpg
case_images: adr-8-adr230176-g001
case_images: Flash electroretinogram showed normal external and intermediate retinal responses (Fig. 1).
case_images: Magnetic resonance imaging (MRI) and fluorodeoxyglucose (FDG)-positron emission tomography (PET) images of our patient. MRI-3T T1w axial slice shows the worsening of parieto-occipital atrophy (A in 2021, B in 2022). FDG-PET axial, coronal, and sagittal slices with correspondent computed tomography slices (C). Z-score maps calculated from FDG-PET imagines exhibited a significant bilateral precuneus, parietal superior and occipital lateral hypometabolism (D).
case_images: adr-8-adr230176-g002.jpg
case_images: PMC10977438_01_adr-8-adr230176-g002.jpg
case_images: adr-8-adr230176-g002
case_images: His brain magnetic resonance imaging (MRI) showed progressive moderate bilateral parieto-occipital atrophy (Fig. 2A, B), which corresponds to a fluorodeoxyglucose (FDG)-positron emission tomography (PET) hypometabolism pattern with a postero-anterior gradient, involving bilateral precuneus, superior parietal, and lateral occipital regions (Fig. 2C,