case_images: PMC6183698_01
case_images: Plain lateral radiographs and MRI demonstrated a fresh vertebral fracture at L3 and T12.. Abbreviations: L, lumbar; T, thoracic.
case_images: cia-13-1929Fig1.jpg
case_images: PMC6183698_01_cia-13-1929Fig1.jpg
case_images: f1-cia-13-1929
case_images: Plain lateral radiographs of the spine and MRI demonstrated a fresh vertebral fracture at L3 and T12 (Figure 1).
case_images: Serum calcium and intact PTH levels.. Notes: After the serum calcium was normalized, it did not change significantly over the three courses of denosumab. PTH continued to be elevated 2 weeks following denosumab administration. Subsequently, PTH was normalized owing to calcium supplementation.. Abbreviations: M, month; Ca, calcium; PTH, parathyroid hormone.
case_images: cia-13-1929Fig2.jpg
case_images: PMC6183698_01_cia-13-1929Fig2.jpg
case_images: f2-cia-13-1929
case_images: D supplementation (Figure 2). During denosumab treatment, there was an immediate reduction in bone turnover markers (Figure 3) and a successful increase in the BMD (DXA: spine BMD, from 0.594 to 0.893 mg/cm2; femoral neck BMD, from 0.445 to 0.456 mg/cm2).
case_images: Bone turnover markers (TRACP-5b, total-P1NP) and eGFR levels.. Notes: TRACP-5b and total-P1NP levels decreased immediately following the first course of denosumab treatment. Renal function diminished mildly over the entire course of treatment.. Abbreviations: M, month; TRACP-5b, tartrate-resistant acid phosphatase type 5; total-P1NP, total N-terminal propeptide of type 1 procollagen; eGFR, estimated glomerular filtration rate.
case_images: cia-13-1929Fig3.jpg
case_images: PMC6183698_01_cia-13-1929Fig3.jpg
case_images: f3-cia-13-1929
case_images: D supplementation (Figure 2). During denosumab treatment, there was an immediate reduction in bone turnover markers (Figure 3) and a successful increase in the BMD (DXA: spine BMD, from 0.594 to 0.893 mg/cm2; femoral neck BMD, from 0.445 to 0.456 mg/cm2). There was a mild deterioration in renal function during the course of his treatment (Figure 3). 1,25(OH)2D was suppressed, while 25(OH)D increased in summer and autumn and decreased in winter (Figure 4).
case_images: 1,25(OH)2D and 25(OH)D levels.. Notes: 1,25(OH)2D was suppressed following eldecalcitol supplementation. 25(OH)D level is higher in summer and autumn and lower in winter.. Abbreviations: M, month; 1,25(OH)2D, 1,25-dihydroxyvitamin D; 25(OH)D, 25-hydroxyvitamin.
case_images: cia-13-1929Fig4.jpg
case_images: PMC6183698_01_cia-13-1929Fig4.jpg
case_images: f4-cia-13-1929
case_images: There was a mild deterioration in renal function during the course of his treatment (Figure 3). 1,25(OH)2D was suppressed, while 25(OH)D increased in summer and autumn and decreased in winter (Figure 4).