case_images: PMC10200991_01
case_images: Computed tomography. (A) Pelvic CT before the surgery showed a huge mass in the middle and lower abdomen accompanied by ascites. (B) Chest CT before the surgery showed bilateral pleural effusion and partial dilatation of the lower lobe of both lungs. (C, D) CT after the surgery showed that the huge masses in the pelvis and the bilateral pleural effusion had disappeared.
case_images: fonc-13-1091956-g001.jpg
case_images: PMC10200991_01_fonc-13-1091956-g001.jpg
case_images: f1
case_images: The chest CT showed moderate effusion in the bilateral pleural cavity and partial dilatation of the lower lobe of both lungs ( Figure 1 ).
case_images: (A) SPECT showed abnormal bone metabolism in the left 8th posterior costal vertebra, 4th and 5th lumbar vertebra, and 1st sacral vertebra. (B) Mammography showed a dense mass in the left breast. (C) CA15-3 and CA 125 level changes are shown.
case_images: fonc-13-1091956-g002.jpg
case_images: PMC10200991_01_fonc-13-1091956-g002.jpg
case_images: f2
case_images: SPECT showed abnormal bone metabolism in the left 8th posterior costal vertebra, the 4th and 5th lumbar vertebra, and the 1st sacral vertebra ( Figure 2A ). One week after the removal of the ovarian mass, the patient's pleural and abdominal effusion completely disappeared, the symptoms of abdominal distension and chest distress were relieved, and CA125 levels decreased from 1,831.8 U/ml back to the normal range ( Figure 2C ). Mammography suggested that there was a dense mass near the chest wall in the deep upper outer quadrant of the left breast with the surrounding structural disorder ( Figure 2B ).
case_images: Immunohistochemical examination of breast cancer (A-D). (A) ER (+). (B) PR (+). (C) HER2(+). (D) Ki-67(30%). Histopathological and immunohistochemical examination of the ovarian tumor (E-L). (E) ER (+). (F) PR (+). (G) HER2 (+). (H) Ki-67 (5%). (I) HE staining. (L) GATA-3(+). (K) GCDFP15(+). (L) Mammaglobin (+). Scale bars: 20 microm; magnification, x40.
case_images: fonc-13-1091956-g003.jpg
case_images: PMC10200991_01_fonc-13-1091956-g003.jpg
case_images: f3
case_images: Immunohistochemistry tests revealed Ki-67 30%, P53 (+), vim (-), CA125 (-), estrogen receptor (ER) (+), progesterone receptor (PR) (+), a-inhibin (-), Placental alkaline phosphatase (PLAP) (-), S-100 (-), mammaglobin (+), GATA-3(+), and gross cystic disease fluid protein 15 (GCDFP15) (+) ( Figures 3A-D ). Figures 3E-H ). FISH showed HER2 without amplification.