case_images: PMC5694584_01
case_images: H+E stain showing the tumor cells replacing the squamous mucosa (left side, 10x). Discohesive malignant tumor cells growing in sheets (H&E, right, 20x).
case_images: CRIPA2017-9052637.001.jpg
case_images: PMC5694584_01_CRIPA2017-9052637.001.jpg
case_images: fig1
case_images: Histology showed discohesive, small to medium sized cells, arranged primarily in solid nests, with focal necrosis (Figure 1).
case_images: Pagetoid involvement of the squamous mucosa by the neoplastic cells (H&E, 20x).
case_images: CRIPA2017-9052637.002.jpg
case_images: PMC5694584_01_CRIPA2017-9052637.002.jpg
case_images: fig2
case_images: There was focal pagetoid involvement of the overlying squamous mucosa (Figure 2).
case_images: The malignant cells are positive for Melan-A and CD56 with a negative cytokeratin AE1/AE3.
case_images: CRIPA2017-9052637.003.jpg
case_images: PMC5694584_01_CRIPA2017-9052637.003.jpg
case_images: fig3
case_images: Then, stains for malignant melanoma were performed and demonstrated that the neoplastic cells were focally positive for S-100 protein while other MM markers including Melan-A and SOX10 were diffusely positive (Figure 3).
case_images: PET scan demonstrating a hypermetabolic mass in the distal esophagus. Also, a hypermetabolic liver lesion and an enlarged gastroesophageal lymph node are seen. This PET scan incidentally revealed bilateral hypermetabolic thyroid lesions.
case_images: CRIPA2017-9052637.004.jpg
case_images: PMC5694584_01_CRIPA2017-9052637.004.jpg
case_images: fig4
case_images: It also revealed a 2 cm hypermetabolic liver lesion and hypermetabolic gastroesophageal lymph node (Figure 4).