case_images: PMC11022868_01
case_images: (A-C) Erythematous, infiltrating plaques on the patient's nose and upper jaw.
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case_images: Skin examination revealed diffuse erythematous papules, infiltrations, and hypertrophic plaques on the entire nose and upper jaw, with a smooth surface (Figure 1A-C).
case_images: (A) Dermoscopy shows bright red background with diffuse telangiectasia but no obvious keratinized hair follicle structure. (B) Biopsy from nose. The epidermis is normal and there are dense perivascular, hair follicles and sweat glands lymphocytic infiltrates. (C) Periadnexial mature lymphocytes was observed in the dermis, mostly of CD4+ T cells.
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case_images: Dermoscopy showed a bright red background with diffuse telangiectasia, but no obvious keratinized hair follicle structures (Figure 2A). T cells (Figure 2B and C). The immunohistochemical panel further revealed positive staining for CD3, CD4, CD8, CD20, CD43, CD68, CD1a, and Ki-67 (10%), while staining for CD123, CD56, GB, PAS, and acid-fast organisms was negative (Figure 3A-K). TCR gene rearrangement analysis did not show any clonal amplification peaks in the target fragment.
case_images: (A-K) CD3 (+), CD4 (+++), CD8 (+), CD20 (+), CD1a (+), CD43 (+), CD68 (+), Ki-67 10% (+), CD123 (-), acid-fast dyeing (-), PAS (-).
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case_images: T cells (Figure 2B and C). The immunohistochemical panel further revealed positive staining for CD3, CD4, CD8, CD20, CD43, CD68, CD1a, and Ki-67 (10%), while staining for CD123, CD56, GB, PAS, and acid-fast organisms was negative (Figure 3A-K). TCR gene rearrangement analysis did not show any clonal amplification peaks in the target fragment.
case_images: (A-C) Erythematous, infiltrating plaques changes had cleared completely.
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case_images: During the outpatient follow-up conducted 2 months later, complete clearance of the skin changes on the nose and upper jaw was observed, leading to the discontinuation of Minocycline treatment (Figure 4A-C).