case_images: PMC11829283_01
case_images: Hematoxylin eosin stain. (a) The ovarian cyst wall was covered with small round cells (x10). (b) The tumor cells were arranged in solid and sheet-like patterns (x200). (c) Displayed mild atypical features (x400). (d) Mesentery lesions showed atypical tumor cells (x40). (e) and intravascular tumor embolus (x100).
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case_images: PMC11829283_01_10.1177_2050313X251321044-fig1.jpg
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case_images: Microscopically, the cystic walls of the bilateral ovaries were partially covered by small blue round cells exhibiting mild dysplasia, and the boundary with the surrounding stroma was unclear (Figure 1(a)). The thickness of tumor cell proliferation varied, with the thickest areas tending to form nodules (Figure 1(b)). The tumor's stroma had rare mitotic figures but was abundant in thin-walled spiral blood vessels (Figure 1(c)). Tumor cells in the mesenteric lesions were histomorphologically identical to those of the ovarian cyst wall (Figure 1(d)), which contained a definite intravascular tumor thrombus (Figure 1(e)).
case_images: Immunohistochemistry stain. Tumor cells of ovarian staining positive for (a) CD10 (x10). (b) positive for ER (x20). (c) Tumor cells staining positive for CD10 in mesenteric lesions (x40). (d) The expression of F-8 was positive in mesenteric vessels and tumor emboli (x100).
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case_images: On immunohistochemistry, the tumor cells were diffusely positive for CD10 (Figure 2(a)), estrogen receptors (ER) (Figure 2(b)), progesterone receptors (PR), and vimentin, but negative for pan-cytokeratin (Pan-CK), smooth muscle antibody (SMA), desmin, CD34, S-100, inhibin-alpha, epithelial membrane antigen (EMA), CD99, LCA, calretinin, cyclin D1, and BCOR. F-8 (Figure 2(d)). Fluorescent in situ hybridization (FISH) analysis revealed the presence of JAZF1 (7p15) disruption (Figure 3).
case_images: Fluorescence in situ hybridization. The presence of disrupted JAZF1 (7p15) genes.
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case_images: F-8 (Figure 2(d)). Fluorescent in situ hybridization (FISH) analysis revealed the presence of JAZF1 (7p15) disruption (Figure 3).