case_images: PMC8551914_01
case_images: EEG showing bilateral frontoparietal polyspikes and spike-and-wave discharges, predominantly on the right hemisphere.
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case_images: PMC8551914_01_fimmu-12-708625-g001.jpg
case_images: f1
case_images: Brain MRI showed very few non-specific white matter lesions and electroencephalography (EEG) showed bilateral frontoparietal polyspikes and spike-and-wave discharges, predominantly on the right hemisphere ( Figure 1 ).
case_images: Brain MRI Flair sequences showing new confluent subcortical white matter lesions compatible with inflammation (red arrows) (A, B).
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case_images: PMC8551914_01_fimmu-12-708625-g002.jpg
case_images: f2
case_images: However, brain MRI showed new subcortical white matter lesions especially in the left parietal lobe ( Figure 2 ), which considering the clinical scenario and the age of the patient were highly suggestive of AE, fulfilling the criteria for probable seronegative AE.
case_images: Clinical course timeline during the first 15 months of follow-up, with three clinical relapses and subsequent improvement after immunotherapy administration. IVIG, intravenous immunoglobulins; mRS, modified Rankin score; RTX, rituximab.
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case_images: PMC8551914_01_fimmu-12-708625-g003.jpg
case_images: f3
case_images: AE, with an excellent clinical response ( Figure 3 ). After 24 months of follow-up, she had a good recovery reaching an mRS of 3, being able to have a partially autonomous life, attend school and maintain social relationships, despite cognitive disturbances being slightly worse than before the disease.