case_images: PMC9974524_01
case_images: Chest x-ray of our patient demonstrating a left sided pleural effusion
case_images: cureus-0015-00000034354-i01.jpg
case_images: PMC9974524_01_cureus-0015-00000034354-i01.jpg
case_images: FIG1
case_images: Chest x-ray showed left mid to lower lung field opacification (Figure 1).
case_images: Chest CT of our patient demonstrating a left sided pleural effusion
case_images: cureus-0015-00000034354-i02.jpg
case_images: PMC9974524_01_cureus-0015-00000034354-i02.jpg
case_images: FIG2
case_images: A CT angiography of the chest showed a moderate to large left-sided pleural effusion with moderate left lower lung compressive atelectasis (Figure 2).
case_images: Circled area showing pleural effusion and arrowed area showing calcified endometrial tumor
case_images: cureus-0015-00000034354-i03.jpg
case_images: PMC9974524_01_cureus-0015-00000034354-i03.jpg
case_images: FIG3
case_images: There was no evidence of lung parenchymal involvement (Figure 3).
case_images: H&E stain of pleural fluid showing large nucleoli, mitotic figures and glands forming high grade adenocarcinoma
case_images: cureus-0015-00000034354-i04.jpg
case_images: PMC9974524_01_cureus-0015-00000034354-i04.jpg
case_images: FIG4
case_images: Final pleural fluid analysis showed tumor cells (Figure 4) positive for uterine serous primary carcinoma markers p53 (Figure 5), PAX8 (Figure 6), and P16 and negative for breast markers GATA3, GCDFP15, and mammaglobin, thereby favoring metastatic uterine papillary serous carcinoma.
case_images: P53 stain of sample showing many tumor clusters with large nuclei
case_images: cureus-0015-00000034354-i05.jpg
case_images: PMC9974524_01_cureus-0015-00000034354-i05.jpg
case_images: FIG5
case_images: Final pleural fluid analysis showed tumor cells (Figure 4) positive for uterine serous primary carcinoma markers p53 (Figure 5), PAX8 (Figure 6), and P16 and negative for breast markers GATA3, GCDFP15, and mammaglobin, thereby favoring metastatic uterine papillary serous carcinoma.
case_images: Immunohistochemistry staining of pleural fluid sample for PAX-8 shows positive staining for endometrial cancer, serous subtype
case_images: cureus-0015-00000034354-i06.jpg
case_images: PMC9974524_01_cureus-0015-00000034354-i06.jpg
case_images: FIG6
case_images: Final pleural fluid analysis showed tumor cells (Figure 4) positive for uterine serous primary carcinoma markers p53 (Figure 5), PAX8 (Figure 6), and P16 and negative for breast markers GATA3, GCDFP15, and mammaglobin, thereby favoring metastatic uterine papillary serous carcinoma.