case_images: PMC11833818_01
case_images: Histologic and ultrastructural findings of chronic thrombotic microangiopathy are observed in renal biopsy . Images from the kidney biopsy demonstrating features of chronic microangiopathy. (a) Light micrograph demonstrating a glomerulus with mild ischemic capillary wall corrugation and segmental capillary wall double contours (arrow) (periodic acid Schiff stain, original magnification 400x). (b) Light micrograph of a glomerulus with segmental capillary wall double contour formation (arrow) (Jones silver stain, original magnification 400x). (c and d) Electron micrographs of glomerular capillaries with widened subendothelial spaces with cellular interposition and deposition of neo-membrane under endothelial cells.
case_images: 10.1177_2050313X251322621-fig1.jpg
case_images: PMC11833818_01_10.1177_2050313X251322621-fig1.jpg
case_images: fig1-2050313X251322621
case_images: The renal biopsy provided significant evidence supporting a diagnosis of TMA (Figure 1).
case_images: Serum creatinine trends before and after dasatinib therapy. This figure shows the progression of serum creatinine levels (mg/dL) in a patient undergoing dasatinib therapy for chronic myeloid leukemia. Key clinical interventions, including renal biopsy (April 2021), dasatinib discontinuation (May 2023), and re-initiation (November 2023), are marked with dashed vertical lines. The transient improvement in renal function following drug cessation highlights its impact on kidney injury. Data points represent measurements taken at specific time intervals.
case_images: 10.1177_2050313X251322621-fig2.jpg
case_images: PMC11833818_01_10.1177_2050313X251322621-fig2.jpg
case_images: fig2-2050313X251322621
case_images: In the months post-discontinuation, her creatinine levels showed a slight improvement from 3.76 to 3.3 mg/dL (Figure 2), suggesting some reversibility in her renal function.