case_images: PMC5909947_01
case_images: Multiple liver nodules, with hypoechoic rim (halo sign).
case_images: JMedLife-11-057-g001.jpg
case_images: PMC5909947_01_JMedLife-11-057-g001.jpg
case_images: F1
case_images: The abdominal ultrasound we performed confirmed these findings (Figures 1, 2). 
case_images: Hypervascular liver metastases.
case_images: JMedLife-11-057-g002.jpg
case_images: PMC5909947_01_JMedLife-11-057-g002.jpg
case_images: F2
case_images: The abdominal ultrasound we performed confirmed these findings (Figures 1, 2). 
case_images: Hematoxylin and eosin staining. Atypical small cell proliferation.
case_images: JMedLife-11-057-g003.jpg
case_images: PMC5909947_01_JMedLife-11-057-g003.jpg
case_images: F3
case_images: The histopathological examination described atypical small and monomorphic cell proliferation, with round nuclei, without obvious nucleolus, with eosinophilic cytoplasm; compact cellular placement, frequently around neoformed capillaries resulting in microacinar structures (Figures 3, 4). 
case_images: Monomorphic cells, with round nuclei and eosinophilic cytoplasm.
case_images: JMedLife-11-057-g004.jpg
case_images: PMC5909947_01_JMedLife-11-057-g004.jpg
case_images: F4
case_images: The histopathological examination described atypical small and monomorphic cell proliferation, with round nuclei, without obvious nucleolus, with eosinophilic cytoplasm; compact cellular placement, frequently around neoformed capillaries resulting in microacinar structures (Figures 3, 4). 
case_images: IHC positive for chromogranin A
case_images: JMedLife-11-057-g005.jpg
case_images: PMC5909947_01_JMedLife-11-057-g005.jpg
case_images: F5
case_images:  Immunohistochemistry (IHC) was positive for CgA, strongly positive for synaptophysin, negative for CDX2 and TTF1, positive for AE1-AE3, with a Ki-67 proliferation marker of 10-15% in the hotspot areas (Figures 5, 6, 7, 8).
case_images: IHC positive for synaptophysin
case_images: JMedLife-11-057-g006.jpg
case_images: PMC5909947_01_JMedLife-11-057-g006.jpg
case_images: F6
case_images:  Immunohistochemistry (IHC) was positive for CgA, strongly positive for synaptophysin, negative for CDX2 and TTF1, positive for AE1-AE3, with a Ki-67 proliferation marker of 10-15% in the hotspot areas (Figures 5, 6, 7, 8).
case_images: IHC positive for synaptophysin - detail
case_images: JMedLife-11-057-g007.jpg
case_images: PMC5909947_01_JMedLife-11-057-g007.jpg
case_images: F7
case_images:  Immunohistochemistry (IHC) was positive for CgA, strongly positive for synaptophysin, negative for CDX2 and TTF1, positive for AE1-AE3, with a Ki-67 proliferation marker of 10-15% in the hotspot areas (Figures 5, 6, 7, 8).
case_images: IHC for Ki67+ (10-15%)
case_images: JMedLife-11-057-g008.jpg
case_images: PMC5909947_01_JMedLife-11-057-g008.jpg
case_images: F8
case_images:  Immunohistochemistry (IHC) was positive for CgA, strongly positive for synaptophysin, negative for CDX2 and TTF1, positive for AE1-AE3, with a Ki-67 proliferation marker of 10-15% in the hotspot areas (Figures 5, 6, 7, 8).