case_images: PMC11249797_01
case_images: PET-FDG scan.
case_images: cro-2024-0017-0001-538384_F01.jpg
case_images: PMC11249797_01_cro-2024-0017-0001-538384_F01.jpg
case_images: F1
case_images: Positron emission tomography-18F-fluorodeoxyglucose (PET-FDG) revealed hypermetabolism at the level of rectal neoplasia, probable superior right lateral-tracheal and aortic/pre-vertebral adenopathy at D12 level, pulmonary, hepatic and node/implant metastases next to the right psoas muscle and bilateral subcutaneous lesions in the abdominopelvic wall (shown in Fig. 1).
case_images: ADC component: carcinoma forming glands, with complex architecture and fusion of glands, and scattered inflammatory cells. H&E, x10.
case_images: cro-2024-0017-0001-538384_F02.jpg
case_images: PMC11249797_01_cro-2024-0017-0001-538384_F02.jpg
case_images: F2
case_images: Rectal biopsy was performed again, confirming the diagnosis of MiNEN, consisting of components of moderately differentiated ADC and NEC (synaptophysin + and Ki-67~70%) (shown in Fig. 2, 3, respectively).
case_images: Neuroendocrine component: sheets and sometimes vaguely organoid structures of small neoplastic cells with hyperchromasia and apoptotic bodies. H&E, x10.
case_images: cro-2024-0017-0001-538384_F03.jpg
case_images: PMC11249797_01_cro-2024-0017-0001-538384_F03.jpg
case_images: F3
case_images: Rectal biopsy was performed again, confirming the diagnosis of MiNEN, consisting of components of moderately differentiated ADC and NEC (synaptophysin + and Ki-67~70%) (shown in Fig. 2, 3, respectively).
case_images: Cutaneous metastasis.
case_images: cro-2024-0017-0001-538384_F04.jpg
case_images: PMC11249797_01_cro-2024-0017-0001-538384_F04.jpg
case_images: F4
case_images: Bone pain worsened and disseminated cutaneous lesions appeared in the trunk, upper and lower limbs, some of them painful, as seen in Figure 4.