case_images: PMC5640091_01
case_images: Brain MRI (sagittal plane) showing normal size of the pituitary.
case_images: esmoopen-2017-000217f01.jpg
case_images: PMC5640091_01_esmoopen-2017-000217f01.jpg
case_images: F1
case_images: Brain MRI was normal (see figure 1), excluding metastatic involvement of the pituitary gland but not hypophysitis, which has also been described in the absence of pituitary gland enlargement.
case_images: The patient's exfoliative dermatitis at baseline (left) and in March 2017 (right).
case_images: esmoopen-2017-000217f02.jpg
case_images: PMC5640091_01_esmoopen-2017-000217f02.jpg
case_images: F2
case_images: At physical examination in March 2017, the patient had a PS of 0, was alert, afebrile, with normal blood pressure, good appetite and disappearance of skin exfoliation (see figure 2).
case_images: Serum hormone levels over time.
case_images: esmoopen-2017-000217f03.jpg
case_images: PMC5640091_01_esmoopen-2017-000217f03.jpg
case_images: F3
case_images: ACTH within normal range (table 1, figure 3). A CT scan of the neck, chest and upper abdomen performed in April 2017 revealed stable disease in the neck, lung and mediastinum (Figure 4).
case_images: CT scan of the thorax performed in April 2017 after nivolumab therapyshowing prolonged stability of  malignancy
case_images: esmoopen-2017-000217f04.jpg
case_images: PMC5640091_01_esmoopen-2017-000217f04.jpg
case_images: F4
case_images: ACTH within normal range (table 1, figure 3). A CT scan of the neck, chest and upper abdomen performed in April 2017 revealed stable disease in the neck, lung and mediastinum (Figure 4).