case_images: PMC4361913_01
case_images: Time course of the plasma concentration during gefitinib (250 mg/day) administration in the present case. The gefitinib concentration increased to 626.6 and 670.0 ng/ml (before and 12 h after dosing, respectively) on day 16. On day 46, the concentration was 538.4 ng/ml at the trough level and 609.2 ng/ml 12 h after the administration of gefitinib. The plasma concentration of gefitinib had reached the steady state by day 16 at the latest.
case_images: cro-0008-0078-g01.jpg
case_images: PMC4361913_01_cro-0008-0078-g01.jpg
case_images: F1
case_images: Thus, we concluded that the plasma concentration of gefitinib had reached the steady state by day 16 at the latest (fig. 1).