case_images: PMC11744991_01
case_images: The coronal section through the thalamus demonstrates intact cranial bones, prominent and enlarged frontal lobes, and an indistinct corpus callosum. An anechoic area is observed at the midline of the brain as indicated by the arrow. (b)This image reveals abnormal widening of both orbits (OR: Orbit) with abnormal echogenicity between them as indicated by the arrow. (c) Three-dimensional surface imaging of the facial features confirms diprosopus, the fused orbits are indicated by the yellow arrow, and the fused auricles are indicated by the blue arrow (E: Eye; N: Nose; M: Mouth)
case_images: 12884_2025_7168_Fig1_HTML.jpg
case_images: PMC11744991_01_12884_2025_7168_Fig1_HTML.jpg
case_images: Fig1
case_images: An anechoic area was observed in the midline of the brain, measuring 13 mm x 9 mm (Fig. 1a), extending into the third ventricle, which appeared dilated by approximately 6 mm. Both eye sockets were significantly widened, with disorganized echoes between them (Fig. 1b). Three-dimensional surface imaging of the facial features revealed the presence of three eye sockets (the lateral eye sockets contained eyeballs, while the central region exhibited fusion without visible eyeballs), two noses, and two mouths (Fig. 1c).
case_images: The specimen post-abortion shows (a) no abnormalities in the trunk and limbs, and (b) diprosopus in the facial features
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case_images: PMC11744991_01_12884_2025_7168_Fig2_HTML.jpg
case_images: Fig2
case_images: The upper and lower eyelids were tightly closed, with a protrusion at the site of facial fusion, possibly indicative of defective development of the earlobe, the appearance of the body below the neck was normal (Fig. 2).
case_images: Postnatal MRI images of this case. (a) T1-weighted imaging reveals fusion of the bilateral maxillofacial bones as indicated by the arrow. (b) MRI T2-weighted imaging shows bilateral enlargement of the frontal lobes, widening of brain gyri, and an increased angle between the anterior edges of the lateral ventricles (F: Frontal Lobe). (c) T2-weighted imaging shows widening of the cranial bones in the frontal region, absence of eyeballs in the fused central eye region as indicated by the arrow, and two paranasal sinuses (E: Eye; PNS: Paranasal Sinuses). (d) T2-weighted imaging displays normal symmetric frontal and parietal lobes, brainstem, and fourth ventricle. (BS: Brain Stem; P: Parietal Lobe; 4 V: Fourth Ventricle)
case_images: 12884_2025_7168_Fig3_HTML.jpg
case_images: PMC11744991_01_12884_2025_7168_Fig3_HTML.jpg
case_images: Fig3
case_images: The MRI (Fig. 3) and CT (Fig. 4) scans performed on the day of induction show duplication and developmental abnormalities of the craniofacial structures in the frontal region.