case_images: PMC8597390_01
case_images: Images obtained from the right superficial lobe parotidectomy: (A) Upper lateral vision of the patient in the surgery room; the parotid tumor has been marked, as well as the incision zone; (B) Surgical zone exposing the different branches of the facial nerve; the superficial lobe of the parotid, including the tumor, was hold with Allis forceps; (C) Surgical resection piece including superficial lobe of the parotid and the tumor; (D) Final result after closing the surgical zone by planes
case_images: RJME-62-1-309-fig1.jpg
case_images: PMC8597390_01_RJME-62-1-309-fig1.jpg
case_images: F1
case_images: According to the findings, the patient was introduced in our Hospital Tumor Committee for head and neck cancers, where we decided to underwent a right superficial lobe parotidectomy (Figure 1).
case_images: (A and B) The tumor showed a lobulated pattern with fibrous septa. It was composed by structures, sometimes papillary, with tubules and microcysts, with eosinophilic discharge. There were not many atypical cells. (C-F) Using immunohistochemistry techniques, it can be observed that the sample was positive for mammaglobin (x10) (C) and S100 (x40) (D). There were many nuclei positive for estrogen receptors (x40) (E). Furthermore, pan-NTRK (x40) (F) was positive with immunohistochemistry. HE staining: (A) x10; (B) x40. HE: Hematoxylin-Eosin; NTRK: Neurotrophic tyrosine receptor kinase
case_images: RJME-62-1-309-fig2.jpg
case_images: PMC8597390_01_RJME-62-1-309-fig2.jpg
case_images: F2
case_images: Fluorescence in situ hybridization (FISH) study indicated a pathogenic translocation between exon 4 of ETV6 and exon 14 of NTRK3, which had been described in MASC (Figure 2).