case_images: PMC10893954_01
case_images: PMC10893954_02
case_images: PMC10893954_03
case_images: PMC10893954_04
case_images: PMC10893954_05
case_images: Development of the Bell score of the five patients after administration of amifampridine
case_images: cureus-0016-00000052935-i01.jpg
case_images: PMC10893954_05_cureus-0016-00000052935-i01.jpg
case_images: FIG1
case_images: Within one day, the patient experienced a reduction in fatigue symptoms and muscular complaints (Bell score 50) (Figure 1). In summary, the Bell score increased significantly in all five patients (Figure 1).
case_images: Development of the cumulative sleep time of the five patients after administration of amifampridine
case_images: cureus-0016-00000052935-i02.jpg
case_images: PMC10893954_05_cureus-0016-00000052935-i02.jpg
case_images: FIG2
case_images: The sleep time was reduced to 8 to 10 hours per 24 hours (Figure 2).
case_images: Results of the discontinuation trial for the Bell score
case_images: cureus-0016-00000052935-i03.jpg
case_images: PMC10893954_05_cureus-0016-00000052935-i03.jpg
case_images: FIG3
case_images: In patient 2, there was a strong reduction in the Bell score from 90 to 60 (day 4) to 20 (day 6) after discontinuation (placebo) from day 4 (Figure 3). In patient 3, the discontinuation (placebo) led to a reduction in the Bell score to 50-60 from day 1 (Figure 3).
case_images: Results of the discontinuation trial for the sleep time
case_images: cureus-0016-00000052935-i04.jpg
case_images: PMC10893954_05_cureus-0016-00000052935-i04.jpg
case_images: FIG4
case_images: The sleep time increased from 7.5 to 10.0 to 11.0 hours (Figure 4). After termination of the discontinuation (verum) from day 4, the Bell score normalized to 80 and the sleep time decreased again to 8.0 hours (day 5) (Figure 4).