case_images: PMC4863413_01
case_images: 12-month-old boy presented to our outpatient department with a history of global developmental delay and infantile spasms since age of 6 months diagnosed as a case of pachygyria. (a and b) T2-weighted axial images show hyperintensities in periventricular (single arrow) and bilateral frontoparietal region with frontal predominant cortical thickening (double arrow) with paucity of sulci favoring cortical dysplasia with pachygyria.
case_images: JCIS-6-15-g002.jpg
case_images: PMC4863413_01_JCIS-6-15-g002.jpg
case_images: F1
case_images: MRI of brain showed frontal predominant pachygyria, periventricular, and bilateral frontoparietal symmetric hyperintensities along with "tigroid-like stripes" or "reverse tigroid pattern" (T2-weighted sagittal image showing radial stripes) [Figures 1, 2, 3a and b] and "leopard-like appearance" - scattered dots in form of hyperintensities on a normal background white matter [Figure 3c and d].
case_images: 12-month-old boy presented to our outpatient department with a history of global developmental delay and infantile spasms since age of 6 months diagnosed as a case of pachygyria. (a and b) T2-weighted axial images show "tigroid-like stripes"(single arrow) along with frontal predominant cortical thickening (double arrow) and (c) fluid-attenuated inversion recovery image shows hyperintensities in bilateral subcortical white matter (thin triple arrow) suggesting myelination abnormality.
case_images: JCIS-6-15-g003.jpg
case_images: PMC4863413_01_JCIS-6-15-g003.jpg
case_images: F2
case_images: MRI of brain showed frontal predominant pachygyria, periventricular, and bilateral frontoparietal symmetric hyperintensities along with "tigroid-like stripes" or "reverse tigroid pattern" (T2-weighted sagittal image showing radial stripes) [Figures 1, 2, 3a and b] and "leopard-like appearance" - scattered dots in form of hyperintensities on a normal background white matter [Figure 3c and d]. Fluid-attenuated inversion recovery image [Figure 2c] showed hyperintensities in bilateral subcortical white matter suggesting myelination abnormality and ruling out the enlargement of perivascular space as a cause of this appearance.
case_images: 12-month-old boy presented to our outpatient department with a history of global developmental delay and infantile spasms since age of 6 months diagnosed as a case of pachygyria. T2-weighted sagittal images (a and b) show radial stripes (single arrow); (c and d): show scattered dots in form of hyperintensities on a normal background white matter (double arrow) - "leopard-like appearance" along with a normal appearing cerebellum
case_images: JCIS-6-15-g004.jpg
case_images: PMC4863413_01_JCIS-6-15-g004.jpg
case_images: F3
case_images: MRI of brain showed frontal predominant pachygyria, periventricular, and bilateral frontoparietal symmetric hyperintensities along with "tigroid-like stripes" or "reverse tigroid pattern" (T2-weighted sagittal image showing radial stripes) [Figures 1, 2, 3a and b] and "leopard-like appearance" - scattered dots in form of hyperintensities on a normal background white matter [Figure 3c and d].
case_images: 12-month-old boy presented to our outpatient department with a history of global developmental delay and infantile spasms since age of 6 months diagnosed as a case of pachygyria. Awake electroencephalogram of the child shows background high amplitude polymorphic delta wave activity with multifocal spikes.
case_images: JCIS-6-15-g005.jpg
case_images: PMC4863413_01_JCIS-6-15-g005.jpg
case_images: F4
case_images: Awake electroencephalogram showed background activity of high amplitude polymorphic delta wave with multifocal spikes [Figure 4].