case_images: PMC8060769_01
case_images: Spleen. Fine-needle aspiration cytology. Large lymphoid cells exhibit
  pleomorphism and occasionally contain erythrocytes in their cytoplasm.
  Wright-Giemsa staining
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case_images: On fine-needle aspiration of the spleen and liver, a large population of pleomorphic lymphocytes of intermediate size (10-15 mum diameter) was found (Figure 1).
case_images: Spleen. Neoplastic lymphoid cells infiltrate red pulp. Haematoxylin and eosin
  staining
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case_images: In the spleen, extensive necrosis and haemorrhage with infiltration of neoplastic lymphoid cells were observed (Figure 2).
case_images: Liver. Hepatic cords are infiltrated by neoplastic lymphoid cells, and
  hepatocytes exhibited degeneration and necrosis. Haematoxylin and eosin
  staining
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case_images: The neoplastic lymphoid cells diffusely infiltrated the hepatic sinusoids and hepatic cords in the liver (Figure 3).
case_images: A neoplastic lymphoid cell in a hepatocyte containing an erythrocyte.
  Transmission electron microscopy. Scale bar = 10 microm
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case_images: Ultra-structurally, the neoplastic cells were often located in the cytoplasm of degenerated hepatocytes and they often contained one or more erythrocytes (Figure 4).
case_images: Liver. Neoplastic lymphoid cells in the cell membrane and cytoplasm are
  positive for CD3. Inset: a neoplastic lymphoid cell inside a hepatocyte is
  also positive
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case_images: Immunohistochemically, the membrane of neoplastic cells was strongly positive for CD3 (Figure 5).
case_images: Liver. Neoplastic lymphoid cells in the cytoplasm are positive for granzyme
  B
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case_images: Granular positivity for granzyme B and T-cell intracellular antigen 1 (TIA-1/GMP-17) were observed in the cytoplasm of neoplastic lymphoid cells (Figures 6 and 7).
case_images: Liver. Neoplastic lymphoid cells in the cytoplasm are positive for
  TIA-1/GMP-17
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case_images: Granular positivity for granzyme B and T-cell intracellular antigen 1 (TIA-1/GMP-17) were observed in the cytoplasm of neoplastic lymphoid cells (Figures 6 and 7).