case_images: PMC9489403_01
case_images: Details of her family cancer history and the results of available family segregation testing for the 3p21.1 deletion.
case_images: CRIG2022-5503505.001.jpg
case_images: PMC9489403_01_CRIG2022-5503505.001.jpg
case_images: fig1
case_images: A 66-year-old female (proband II-5, Figure 1) presented with a personal history of left choroidal melanoma, cutaneous BCC, and multiple recurrent meningioma in the context of a family history of various cancer types (Figure 1). Her heterozygous sister (Figure 1; II-6) died of hepatoid carcinoma of the pancreas at 59 years; the hepatoid carcinoma had loss of nuclear staining for BAP1 on IHC.
case_images: (a) An array profile of the deletion and (b) the breakpoints of the deletion and involved OMIM morbid genes.
case_images: CRIG2022-5503505.002.jpg
case_images: PMC9489403_01_CRIG2022-5503505.002.jpg
case_images: fig2
case_images: Her heterozygous sister (Figure 1; II-6) died of hepatoid carcinoma of the pancreas at 59 years; the hepatoid carcinoma had loss of nuclear staining for BAP1 on IHC.