case_images: PMC7294959_01
case_images: Atypical lymphocytes in peripheral blood showing classical "flower cell" morphology. Leishman stain, magnification x 1000.
case_images: 1678-9849-rsbmt-53-e20200060-gf1.jpg
case_images: PMC7294959_01_1678-9849-rsbmt-53-e20200060-gf1.jpg
case_images: f1
case_images: Laboratory data revealed leukocytosis (142.3 x 109/L - 78% lymphocytes, some with "flower cell" morphology [Figure 1]), hypercalcemia, elevated serum lactate dehydrogenase, and acute renal dysfunction without anemia or thrombocytopenia.
case_images: Blood lymphocyte immunophenotyping by flow cytometry. Lymphocytes (marked by red color in dot-plots) were CD3+ (A), CD5+ (B), and CD25+ (C). D: CD3+ T-lymphocytes with CD4+/CD8- phenotype (marked by pink color in dot-plots) in 97.3% of cells analyzed.
case_images: 1678-9849-rsbmt-53-e20200060-gf2.jpg
case_images: PMC7294959_01_1678-9849-rsbmt-53-e20200060-gf2.jpg
case_images: f2
case_images: Blood and CSF lymphocyte immunophenotyping by flow cytometry revealed positivity for CD3, CD4, CD5, CD25, and CD38 markers, and negativity for CD8 (Figure 2).