case_images: PMC8565708_01
case_images: A, B. Morphology analysis of the BM cells reveals a population of 27% medium sized blast cells that present irregular nuclear outlines, fine chromatin and reduced agranular basophilic cytoplasm.
case_images: acc-07-04-57-g001.jpg
case_images: PMC8565708_01_acc-07-04-57-g001.jpg
case_images: acc-07-04-57-g001
case_images: U/L; reference range 120 - 246 U/L), a marker of tumor cell lysis. Under these circumstances, BM aspiration was performed and morphology analysis identified 27% medium sized blast cells with irregular nuclear outline, lax chromatin and reduced basophilic cytoplasm (Figures 1A and 1B).
case_images: Flow cytometry was performed on the BM cells. The blastic plasmacytoid dendritic cell population is highlighted in orange. The blasts were intermediate positive for CD45 (a); partially positive for CD117 and CD7 (b, c); positive for CD4, CD36, CD56, CD123, HLA-DR and NG2 (d, e, f, g, h, i) and negative for CD94 (f), CD34 (j), cyCD3 and cyCD79a (k) and cyMPO (l).
case_images: acc-07-04-57-g002.jpg
case_images: PMC8565708_01_acc-07-04-57-g002.jpg
case_images: acc-07-04-57-g002
case_images: The precursor cell marker CD34 was absent and lineage markers cyMPO, cyCD79a, cyCD3 and CD94 were also negative (Figure 2).