case_images: PMC4313754_01
case_images: Structurally dissimilar base chemical structures of clopidogrel and ticagrelor. Note the base chemical structure similarity of clopidogrel and ticlopidine, and to a lesser extent prasugrel.
case_images: apa-5-51-g001.jpg
case_images: PMC4313754_01_apa-5-51-g001.jpg
case_images: F1
case_images: Given his reaction to three antiplatelet agents, and after reviewing the molecular structure of all four drugs (Fig. 1), as well as available literature on clopidogrel sensitisation and its cross-reactivity towards ticlopidine and prasugrel, there was significant concern about the risk of similar but more severe and rapid onset hypersensitivity reaction.