case_images: PMC11362090_01
case_images: Enhanced CT scan of the chest.
case_images: fphar-15-1453595-g001.jpg
case_images: PMC11362090_01_fphar-15-1453595-g001.jpg
case_images: F1
case_images: Contrast-enhanced chest computed tomography (CT) confirmed primary cancer in the upper lobe of the left lung, with a maximum length of 7.8 cm x 7.5 cm (Figure 1).
case_images: The kinetics of biochemical parameters reflecting liver function before and after withdrawal of ICIs and chemotherapy over the entire period are shown, with indicators for every approach.
case_images: fphar-15-1453595-g002.jpg
case_images: PMC11362090_01_fphar-15-1453595-g002.jpg
case_images: F2
case_images: Total and direct bilirubin levels were initially within the normal range at 12.7 and 3.9 mumol/L, respectively (Figure 2). On day 71, his liver function had almost fully recovered, evident through the nearly normalized levels of ALT, AST, ALP, and GGT by the time of discharge (Figure 2).
case_images: Liver biopsy revealed patchy focal necrosis (A), and infiltrating inflammatory cells, mainly lymphocytes in the portal area (B), and enrichment of CD4+
  (C) and CD8+
  (D) in the portal area.
case_images: fphar-15-1453595-g003.jpg
case_images: PMC11362090_01_fphar-15-1453595-g003.jpg
case_images: F3
case_images: On day 32, histopathological examination of the liver biopsy sample revealed the presence of focal necrosis, acidophilic bodies, mild steatosis and cholestasis (Figure 3). A lymphocytic infiltration was noted within the sinusoids and was found to be abundant within the portal area (Figures 3A,B).