case_images: PMC11794952_01
case_images: Right axilla demonstrating tender erythematous nodules after 4 months of treatment with nirogacestat at initial evaluation.
case_images: gr1.jpg
case_images: PMC11794952_01_gr1.jpg
case_images: fig1
case_images: On physical examination there were scattered firm tender nodules of the groin and axilla (Fig 1) consistent with Hurley stage 1 HS.
case_images: Right axilla demonstrating postinflammatory hyperpigmentation, nodules, scarring, and draining sinus tract after 10 months of treatment with nirogacestat.
case_images: gr2.jpg
case_images: PMC11794952_01_gr2.jpg
case_images: fig2
case_images: Over a 10-month period of treatment with nirogacestat, the patient's HS continued to progress to Hurley stage 3, demonstrating well-formed sinus tracts, scarring, and draining nodules affecting the axilla (Fig 2) and groin.