case_images: PMC10859473_01
case_images: Clinicopathological features of the two patients. In patient 1, the splenectomy specimen revealed significant splenic enlargement, as demonstrated in images (A, B). Bone marrow histology of patient 2, stained with HE (C), x200; (D), x400), exhibited infiltration of lymphoma cells. These cells appeared as small to intermediately sized lymphoid cells within the medullary sinus, displaying slight irregularities, loose chromatin, and inconspicuous nucleoli. Immunostaining indicated that these cells were positive for CD3 (E), x400) and negative for CD5 (F), x200). A PET-CT scan performed on patient 1 before (G), 2/1/2021) and after (H), 1/26/2022) allo-HSCT demonstrated complete remission. Post allo-HSCT, patient 2 showed no abnormalities on PET-CT scans conducted on 5/13/2021 (I) and 1/26/2022 (J).
case_images: fonc-14-1345464-g001.jpg
case_images: PMC10859473_02_fonc-14-1345464-g001.jpg
case_images: f1
case_images: T cell receptor (TCR) rearrangement results showed TCRGA+, TCRGB+, and TCRD+. The diagnosis of HSTCL was conclusively confirmed through a bone marrow biopsy ( Figures 1C-F ). The PET-CT scan was excluded because of its excessive cost. The diagnosis of HSTCL was considered based on these data. The PET-CT scan ( Figure 1I ) showed no abnormal glucose uptake by the spleen. Repeat PET-CT ( Figure 1J ) scans were negative.
case_images: Clinical course of patients 1 (A) and 2 (B).
case_images: fonc-14-1345464-g002.jpg
case_images: PMC10859473_02_fonc-14-1345464-g002.jpg
case_images: f2
case_images: The patient remains disease-free at day 902 after transplant ( Figure 2B ).
case_images: PMC10859473_02
case_images: Clinicopathological features of the two patients. In patient 1, the splenectomy specimen revealed significant splenic enlargement, as demonstrated in images (A, B). Bone marrow histology of patient 2, stained with HE (C), x200; (D), x400), exhibited infiltration of lymphoma cells. These cells appeared as small to intermediately sized lymphoid cells within the medullary sinus, displaying slight irregularities, loose chromatin, and inconspicuous nucleoli. Immunostaining indicated that these cells were positive for CD3 (E), x400) and negative for CD5 (F), x200). A PET-CT scan performed on patient 1 before (G), 2/1/2021) and after (H), 1/26/2022) allo-HSCT demonstrated complete remission. Post allo-HSCT, patient 2 showed no abnormalities on PET-CT scans conducted on 5/13/2021 (I) and 1/26/2022 (J).
case_images: fonc-14-1345464-g001.jpg
case_images: PMC10859473_02_fonc-14-1345464-g001.jpg
case_images: f1
case_images: T cell receptor (TCR) rearrangement results showed TCRGA+, TCRGB+, and TCRD+. The diagnosis of HSTCL was conclusively confirmed through a bone marrow biopsy ( Figures 1C-F ). The PET-CT scan was excluded because of its excessive cost. The diagnosis of HSTCL was considered based on these data. The PET-CT scan ( Figure 1I ) showed no abnormal glucose uptake by the spleen. Repeat PET-CT ( Figure 1J ) scans were negative.
case_images: Clinical course of patients 1 (A) and 2 (B).
case_images: fonc-14-1345464-g002.jpg
case_images: PMC10859473_02_fonc-14-1345464-g002.jpg
case_images: f2
case_images: The patient remains disease-free at day 902 after transplant ( Figure 2B ).
case_images: Using data from published cases, a Kaplan-Meier survival analysis was conducted to assess the impact of various risk factors. The findings revealed that Patients under 45 years of age (A, D), transplant status of CR (B, E) and relapse after transplantation (C, F) exhibited a improved OS and PFS.
case_images: fonc-14-1345464-g003.jpg
case_images: PMC10859473_02_fonc-14-1345464-g003.jpg
case_images: f3
case_images: PFS nodes with post-transplant progression-free survival time, but only 25 patients reported explicit PFS durations. Prognosis may be affected by factors such as age ( Figures 3A, D ), the state of remission before a transplant ( Figures 3B, E ) and relapse after transplantation ( Figures 3C, F ) when considering the operating system.