case_images: PMC3809367_01
case_images: Typical features of EDS-VIII in our patient. (a) Leg ulcer within a brownish atrophic pretibial plaque. (b) Brownish atrophic plaque on the opposite leg. (c) Visible venous pattern on the trunk. (d) Atrophic scar on the right thigh. (e) Apical root resorption and gingival recession.
case_images: CRIM.DM2013-469505.001.jpg
case_images: PMC3809367_01_CRIM.DM2013-469505.001.jpg
case_images: fig1
case_images: He had a 6 by 9 cm ulcer on the anterior aspect of the left leg (Figure 1(a)) and bilateral brownish atrophic plaques on the pretibial areas mimicking necrobiosis lipoidica (Figure 1(b)). His skin was thin with visible venous pattern on the trunk (Figure 1(c)). Four atrophic scars were noted on his right knee and both thighs (Figure 1(d)). He had periodontitis with apical root resorption and gingival recession (Figure 1(e)). 
case_images: Transmission electron microscopy analysis on skin biopsy. (a) Irregular interfibrillar spaces (7750x). (b) Collagen cauliflowers (16700x).
case_images: CRIM.DM2013-469505.002.jpg
case_images: PMC3809367_01_CRIM.DM2013-469505.002.jpg
case_images: fig2
case_images: Transmission electron microscopy analysis on skin biopsy revealed irregular interfibrillar spaces (Figure 2(a)), collagen fibers with variable diameter, and collagen cauliflowers (Figure 2(b)).