case_images: PMC6203236_01
case_images: Computed tomography image of the patient's neck demonstrates a homogeneous increase in the size of the left submandibular gland (arrow). No lymphadenopathy was present.
case_images: gr1.jpg
case_images: PMC6203236_01_gr1.jpg
case_images: fig0005
case_images: Computed tomography imaging of the mass revealed left submandibular gland enlargement and no cervical lymphadenopathy (Fig. 1).
case_images: Permanent histopathology specimen of submandibular gland lesion (A) shows large regular islands of carcinoid tumor cells in a so-called organoid pattern on the right, with residual submandibular acini and ducts on the left (Hematoxylin & eosin staining; original magnification x100). (B) On higher (x400) magnification, features characteristic of neuroendocrine tumor cells are apparent with hematoxylin & eosin staining showing cells with a characteristic coarsely granular "salt-and-pepper" chromatin. (C) Positive chromogranin immunostaining is consistent with neuroendocrine tumor cells.
case_images: gr2.jpg
case_images: PMC6203236_01_gr2.jpg
case_images: fig0010
case_images: Immunohistochemistry was again positive for chromogranin and synaptophysin, consistent with the previous FNA and was (Fig. 2).