case_images: PMC9035918_01
case_images: Abdominal CT shows a tumor measuring approximately 7 cm in diameter in the left abdomen (a, arrowheads) with nearby swollen mesenteric lymph nodes and lymph node enlargement around the abdominal aorta (b, arrowheads). Chest CT shows a round tumor measuring approximately 1 cm in diameter in contact with the subclavian artery in the apical lobe of the right lung (c, arrowhead) and mediastinal lymph node enlargement in contact with the superior vena cava (d, arrowhead).
case_images: crg-0016-0195-g01.jpg
case_images: PMC9035918_01_crg-0016-0195-g01.jpg
case_images: F1
case_images: However, abdominal CT revealed a tumor approximately 7 cm in diameter in the left abdomen (Fig. 1a) with nearby swollen mesenteric lymph nodes and lymph node enlargement around the abdominal aorta (Fig. 1b). Chest CT revealed a round tumor approximately 1 cm in diameter in contact with the subclavian artery in the apical lobe of the right lung (Fig. 1c) and mediastinal lymph node enlargement in contact with the superior vena cava (Fig. 1d).
case_images: Enteroscopy shows a whole circumferential ulcer is seen in the jejunum approximately 20 cm from the ligament of Treitz. a Anal side of the ulcer. b A whole circumferential dirty ulcer. PET shows accumulations in the small-intestinal tumor (c), nearby mesenteric lymph nodes (d), lymph nodes around the abdominal aorta (d), lung tumor (e, arrowhead), and mediastinal lymph node in the apical lobe of the right lung (e, arrow). PET, positron emission tomography.
case_images: crg-0016-0195-g02.jpg
case_images: PMC9035918_01_crg-0016-0195-g02.jpg
case_images: F2
case_images: Enteroscopy using double-balloon endoscopy revealed a whole circumferential ulcer in the jejunum approximately 20 cm from the ligament of Treitz (Fig. 2a, b). Positron emission tomography revealed positive findings in the small-intestinal tumor (Fig. 2c), nearby mesenteric lymph nodes (Fig. 2d), lymph nodes around the abdominal aorta (Fig. 2d), lung tumor, and mediastinal lymph node in the apical lobe of the right lung (Fig. 2e).
case_images: Pathological examination. Hematoxylin and eosin staining reveals the tumor is a poorly differentiated adenocarcinoma (a). Immunohistochemical staining for TTF1 (b) and CK7 (c) is positive. Immunohistochemical staining for CK20 (d), CDX2 (e), and PAX8 (f) is negative. Original magnification, x400.
case_images: crg-0016-0195-g03.jpg
case_images: PMC9035918_01_crg-0016-0195-g03.jpg
case_images: F3
case_images: Analysis of a biopsy specimen obtained from the ulcer revealed a poorly differentiated carcinoma (Fig. 3a) consistent with a lung origin. Immunohistochemical staining of the specimen showed that it was positive for thyroid transcription factor 1 (TTF1) (Fig. 3b) and cytokeratin 7 (CK7) (Fig. 3c) and negative for cytokeratin 20 (CK20) (Fig. 3d), GATA-binding protein 3 (GATA3), caudal-type homeobox protein 2 (CDX2) (Fig. 3e), and paired box 8 (PAX8) (Fig. 3f).