case_images: PMC5660822_01
case_images: MRI of the brain displaying left frontoparietal dominant extracranial soft tissue lesion.
case_images: CRIT2017-6401086.001.jpg
case_images: PMC5660822_01_CRIT2017-6401086.001.jpg
case_images: fig1
case_images: Further imaging of the mass was ordered with an MRI of the brain which showed focal cranial bone marrow infiltration and a left frontoparietal 6 x 2 x 9 cm dominant extracranial soft tissue lesion (Figure 1) with thickened enhanced dura below this site.
case_images: Biopsy of this lesion confirmed an EBV positive B-cell lymphoma. (a) Histology showed large atypical lymphocytes; hematoxylin and eosin (H&E) (x40 magnification). (b) Immunostaining revealed that these lymphocytes were CD20 positive. (c) In situ hybridization with EBV-encoded small RNA (EBER) was additionally positive (x40 magnification).
case_images: CRIT2017-6401086.002.jpg
case_images: PMC5660822_01_CRIT2017-6401086.002.jpg
case_images: fig2
case_images: A core biopsy of the mass revealed large atypical lymphocytes (Figure 2(a)) that stained positive for the B-cell marker CD20 (Figure 2(b)), with a high Ki-67 proliferative index and positive EBER staining (detecting for in situ EBV replication) (Figure 2(c)).