case_images: PMC5240303_01
case_images: a- b patient 1. c-d patient 2. a and c H&E 20x. Tubulointerstitial inflammation with eosinophils and acute tubular epithelial cell injury. b and c DIF 20x. IgG reactive interstitial plasma cells with tubulointerstitial inflammation
case_images: 40425_2016_205_Fig1_HTML.jpg
case_images: PMC5240303_01_40425_2016_205_Fig1_HTML.jpg
case_images: Fig1
case_images: Renal biopsy (Fig. 1) demonstrated diffuse active tubulointerstitial nephritis with severe acute tubular cell injury. Immunofluorescence revealed no glomerular, tubular or vascular wall immune staining (Fig. 1).
case_images: Immunohistochemistry of renal biopsies from patients 2 (top panel: a) and 1 (bottom panel: b) reveals an inflammatory infiltrate composed of CD4 and CD8 T-cells and macrophages.
case_images: 40425_2016_205_Fig2_HTML.jpg
case_images: PMC5240303_01_40425_2016_205_Fig2_HTML.jpg
case_images: Fig2
case_images: Immunohistochemistry revealed an inflammatory infiltrate composed of CD4 and CD8 T-cells and macrophages (Fig. 2).    In May 2015, the patient presented with a new subcutaneous nodule on the anterior left leg (Fig. 2), which was confirmed as metastatic melanoma. Immunohistochemistry revealed an inflammatory infiltrate composed of CD4 and CD8 T-cells and macrophages (Fig. 2).