case_images: PMC3902072_01
case_images: PMC3902072_02
case_images: Skin lesion on the right leg of patient.
case_images: 40064_2013_785_Fig1_HTML.jpg
case_images: PMC3902072_02_40064_2013_785_Fig1_HTML.jpg
case_images: Fig1
case_images: Physical examination showed two large infiltrated and ulcerated skin lesions on her right leg (Figure 1).
case_images: MR imaging showing a proliferative lesion on right fronto-rolandic region.
case_images: 40064_2013_785_Fig2_HTML.jpg
case_images: PMC3902072_02_40064_2013_785_Fig2_HTML.jpg
case_images: Fig2
case_images: Brain MRI, including DWI, confirmed the presence of a proliferative lesion with a slight hemorrhagic component and leptomeningeal contrast enhancement (Figure 2).
case_images: T cell clonality testing by PCR analysis of TCR Gamma gene rearrangements. TCR clonality profiles were obtained by extracted DNA from the diagnostic tissue for MF (A) and from cells (B) derived from CSF. The arrows indicate the TCRG monoclonal rearrangement.
case_images: 40064_2013_785_Fig3_HTML.jpg
case_images: PMC3902072_02_40064_2013_785_Fig3_HTML.jpg
case_images: Fig3
case_images: A molecular TCR test was also performed on the cerebrospinal fluid (CSF) using different primer such described in previous studies (Van Dongen et al), and confirmed the of expression of clone T g/ of the same size of the ones observed in the skin biopsy (Figure 3).