case_images: PMC10619726_01
case_images: PMC10619726_02
case_images: Radiographs of index case (Patient 1) demonstrating (1A) sclerotic ribs and vertebrae (aged 9 months), (1B) under-modelling of the femur with metaphyseal sclerosis and Erlenmeyer flask deformity (aged 13 months) (1C) Metaphyseal sclerosis of the left hand (aged 13 months).
case_images: fendo-14-1258340-g001.jpg
case_images: PMC10619726_02_fendo-14-1258340-g001.jpg
case_images: f1
case_images: Radiological evaluation revealed sclerotic ribs ( Figure 1A ), Erlenmeyer flask deformity of long bones with sclerotic metaphyses ( Figure 1B ) and dense sclerotic bands were seen in the metaphyses of tubular bones in the hand ( Figure 1C ).
case_images: Radiographs of index case (Patient 1) demonstrating (2A) diffuse sclerosis of the skull vault, base and the cervical spine (aged 10 months) (2B) Valgus deformity with Erlenmeyer flask deformity of the distal femur and proximal tibia bilaterally with metaphyseal sclerosis and evidence of multiple growth arrest lines (aged 5 years, 4 months).
case_images: fendo-14-1258340-g002.jpg
case_images: PMC10619726_02_fendo-14-1258340-g002.jpg
case_images: f2
case_images: Skull radiograph showed diffuse sclerosis ( Figure 2A ). He was able to stand at 2 years of age and was walking by 3 years but developed progressive skeletal dysplasia with significant valgus deformity ( Figure 2B ), flat feet and ankle inversion by three and a half years of age.
case_images: Facial computed tomography (CT) reconstruction images for Patient 2 demonstrating progression of osteonecrosis of the jaw from (3A) baseline at 7 years of age and (3B, 3C) most recent scan at 12 years of age.
case_images: fendo-14-1258340-g003.jpg
case_images: PMC10619726_02_fendo-14-1258340-g003.jpg
case_images: f3
case_images: The osteonecrosis has progressed steadily since his first presentation to gradually involve the entire mandible with some mild left mandibular expansion (Figure 3).