case_images: PMC10699157_01
case_images: Patient condition at the time of admission.
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case_images: PMC10699157_01_10.1177_2333794X231216556-fig1.jpg
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case_images: Patient condition at the time of admission was shown in Figure 1. Previously at our institution, the patient who had been treated for seizures had been seizure-free for nearly 3 years.
case_images: Biopsy of left thigh skin specimen, Immunofluorescence staining: IgA, IgM, IgG: Negative; C1q; C3c; Fibrinogen: Mildly positive.
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case_images: PMC10699157_01_10.1177_2333794X231216556-fig2.jpg
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case_images: A skin biopsy taken from a lesion on his skin showed epidermal detachment and inflammatory cell infiltration (Figure 2 & Figure 3).
case_images: Biopsy of the left thigh skin specimen revealed the lesion to be concentrated in the epidermis at the basal membrane. The specimen exhibited areas of burns containing fluid and inflammatory cells, necrotic lesions, and epidermal surface dissection. Histopathology showed necrotic epidermis, with spongiosis and necrotic keratinocytes. There were also lymphocyte infiltrates present in the dermis.
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case_images: PMC10699157_01_10.1177_2333794X231216556-fig3.jpg
case_images: fig3-2333794X231216556
case_images: A skin biopsy taken from a lesion on his skin showed epidermal detachment and inflammatory cell infiltration (Figure 2 & Figure 3).
case_images: Patient condition after 4 weeks of treatment.
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case_images: Cyclosporine was, therefore, added at a starting dose of 5 mg/kg/day in combination with a lower dose of corticosteroids for the next 4 weeks, resulting in significant clinical improvement in systemic redness (Figure 4).