case_images: PMC10601801_01
case_images: a, b Acrocyanosis of the patient's distal lower extremities, which began shortly after initiating neoadjuvant FLOT chemotherapy for her gastric adenocarcinoma. Complete clinical resolution was observed shortly after surgical resection of the gastric tumor.
case_images: cro-2023-0016-0001-534278_F01.jpg
case_images: PMC10601801_01_cro-2023-0016-0001-534278_F01.jpg
case_images: F1
case_images: However, during the following week, she developed symptomatic acrocyanosis in her feet (Fig. 1).
case_images: Overall trend of Hb and hemolytic markers across various treatments modalities. a Hb (g/L). b Haptoglobin (g/L). c Total bilirubin (micromol/L). d Lactate dehydrogenase (U/L). The dotted black line depicts the time of gastric resection, which occurred on May 30, 2022.
case_images: cro-2023-0016-0001-534278_F02.jpg
case_images: PMC10601801_01_cro-2023-0016-0001-534278_F02.jpg
case_images: F2
case_images: Hb showed notable improvement, trending upward from 70 to 120 g/L by July 28, 2022 (shown in Fig. 2). Her hemolytic markers showed normalization post-operatively, with a total bilirubin of 9 micromol/L, direct bilirubin of 3 micromol/L, and LDH of 360 U/L.
case_images: Timeline of disease diagnosis and management.
case_images: cro-2023-0016-0001-534278_F03.jpg
case_images: PMC10601801_01_cro-2023-0016-0001-534278_F03.jpg
case_images: F3
case_images: She now remains on surveillance for her gastric cancer, with no clinical or radiographic signs of recurrence (Fig. 3).