case_images: PMC11745275_01
case_images: Normochromic papule, with a smooth and regular surface, fibroelastic consistency, located on the anterolateral surface of the right leg.
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case_images: fig0005
case_images: On examination, he had a normochromic nodule on the anterolateral surface of the right leg, which was painful on deep palpation (Fig. 1).
case_images: Light Microscopy (A) Rectified epidermis. Dermis with proliferation of spindle-shaped and stellate cells embedded in a myxoid matrix, forming well-circumscribed lobes, separated by fibrous septa (Hematoxylin & eosin, x40). (B) Proliferation of spindle-shaped and stellate cells, forming well-circumscribed nodules, separated by fibrous septa (Hematoxylin & eosin, x100).
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case_images: PMC11745275_01_gr2.jpg
case_images: fig0010
case_images: On microscopy, the epidermis appeared rectified (Fig. 2).
case_images: Light Microscopy (A) Cellular atypia or mitoses are not observed (Hematoxylin & eosin, x100). (B) Detail of stellate and spindle-shaped cells without atypia (Hematoxylin & eosin, x400).
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case_images: PMC11745275_01_gr3.jpg
case_images: fig0015
case_images: In the dermis, there was a multilobular proliferation of spindle-shaped or stellate cells, with vesicular nuclei and surrounded by abundant mucin (Fig. 3).
case_images: Immunohistochemistry (A) anti-S100 protein antibody positive in the neoplastic cells and in the adjacent nerve, in the left low corner (x100). (B and C) vimentin antibody showing positivity in the neoplastic cells (x100). (D) Ki67 antibody indicating a low cell proliferation index (x100).
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case_images: PMC11745275_01_gr4.jpg
case_images: fig0020
case_images: Immunohistochemistry was performed with S100 protein (polyclonal; Fig. 4A), which was positive, as well as vimentin (Fig. 4B and 4 C). Ki67 immunostaining indicated a low cell proliferation index (Fig. 4D).