case_images: PMC11150044_01
case_images: (a) Thyroid ultrasonography images depicting a solid, hypoechoic nodule with a well-defined border on the left lobe. (b) Fine-needle aspiration cytology findings revealing numerous spindle-shaped tall cells with a densely packed structure and an enlarged nucleus-to-cytoplasm ratio.
case_images: CRIE2024-6517236.001.jpg
case_images: PMC11150044_01_CRIE2024-6517236.001.jpg
case_images: fig1
case_images: T4, but the anti-thyroid-peroxidase antibody levels were higher than average (548 IU/mL, reference range: <34 IU/mL). Thyroid ultrasonography revealed a heterogeneous echo texture in the thyroid gland and a solid, hypoechoic, wider-than-tall nodule measuring 11.8 x 10.2 x 12.4 mm in size with a smooth margin and no calcification (Figure 1(a)). Fine-needle aspiration cytology revealed papillary growth of tall and spindle-shaped cells with elongated nuclei and an increased nucleus-to-cytoplasm ratio (Figure 1(b)).
case_images: (a) Microscopic view of the tumor, revealing numerous spindle-shaped cells with a morular arrangement. (b) Cribriform structure was prominent. (c) The tumor was positive for beta-catenin in the cytoplasm and nuclei and (d) negative for thyroglobulin. (e) The tumor stained negative for PAX8 but (f) positive for TTF-1 in areas other than morular areas. (g) Staining for BRAF VE1 was negative.
case_images: CRIE2024-6517236.002.jpg
case_images: PMC11150044_01_CRIE2024-6517236.002.jpg
case_images: fig2
case_images: TTF-1 was also positive, except in the morular regions (Figure 2).