case_images: PMC11791248_01
case_images: Post-contrast abdominal CT scan showing a well-defined hypodense lesion measuring 20 x 21 mm in the pancreatic body. The lesion is clearly delineated from the surrounding pancreatic parenchyma.
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case_images: Abdominal CT scan revealed a well-defined polycystic tumor measuring approximately 2 cm in the pancreatic body (Fig. 1).
case_images: Pancreatic MRI. (a) Axial T1-weighted image (fat-suppressed, non-enhanced) showing a hypointense mass in the pancreatic body. (b) Axial T2-weighted image (fat-suppressed) depicting the lesion as heterogeneously hyperintense.
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case_images: Importantly, the mass exhibited no communication with the main pancreatic duct (Fig. 2).
case_images: Histologic analysis of the pancreatic mass. (a) Macroscopic appearance of the tumor, showing a well-circumscribed, encapsulated lesion. (b) Histologic section (Hematoxylin and Eosin [H&E] stain) displaying spindle-shaped cells arranged in a palisading pattern without atypia. Abnormal cells are marked with arrows. Original magnification x100. (c) Immunohistochemistry analysis of the tumor, demonstrating strong and diffuse S-100 protein expression in the spindle cells (brown staining). Original magnification x4. Special staining highlights the cellular architecture and confirms the schwannoma diagnosis. Abnormal findings are indicated with arrows.
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case_images: Immunohistochemistry analysis displayed highly positive protein S-100 expression in the spindle cells, with negative results for CD34, CD117, KIT, DOG1, and smooth muscle actin (SMA) (Fig. 3), confirming the diagnosis of a pancreatic schwannoma.