case_images: PMC11066155_01
case_images: Patient's chest CT, bronchoscopy, and gastroscopy examination. (A) The arrow indicates the narrowed left main bronchus. (B) The arrow indicates the narrowed esophagus. (C) Bronchoscopy shows narrowing of the left main bronchus with white necrotic material attached. (D) Gastroscopy shows circumferential narrowing of the esophagus with smooth mucosa.
case_images: fonc-14-1375035-g001.jpg
case_images: PMC11066155_01_fonc-14-1375035-g001.jpg
case_images: f1
case_images: B ). Bronchoscopic examination revealed a narrowing of the openings of the bilateral main bronchi and a narrowing of the lumen of the left main bronchus with easily bleeding mucosa ( Figure 1C ). During gastroscopy, circumferential stenosis was observed at 30 cm from the incisors, preventing the passage of the endoscope, with the esophageal mucosa appearing smooth ( Figure 1D ).
case_images: Patient's bronchial biopsy pathology. (A) Bronchial biopsy pathology (H&E staining, x100). (B) Strong positive expression of P16 (immunohistochemistry staining, x100).
case_images: fonc-14-1375035-g002.jpg
case_images: PMC11066155_01_fonc-14-1375035-g002.jpg
case_images: f2
case_images: Immunohistochemistry showed p16 (+), CK5/6 (+), p40 (partially +), and PD-L1-22C3 (tumor proportion score (TPS): -) ( Figure 2 ).
case_images: Comparison of barium swallow radiography before and after treatment. (A) Before treatment, localized narrowing of the esophageal lumen, involving an area of approximately 38 mm, with dilation above the narrowed segment. (B) After treatment, the local esophageal wall mucosa appears slightly irregular.
case_images: fonc-14-1375035-g003.jpg
case_images: PMC11066155_01_fonc-14-1375035-g003.jpg
case_images: f3
case_images: Barium meal examination showed localized esophageal luminal stenosis of approximately 38 mm, with dilation above the stenosis ( Figure 3A ). Barium meal examination showed localized esophageal wall mucosa appears slightly irregular ( Figure 3B ).
case_images: SCC antigen levels during treatment and observation (reference range 0-2.5 ng/mL). SCC, squamous cell carcinoma.
case_images: fonc-14-1375035-g004.jpg
case_images: PMC11066155_01_fonc-14-1375035-g004.jpg
case_images: f4
case_images: During chemotherapy, the patient's SCC antigen levels initially decreased and then fluctuated and increased ( Figure 4 ).
case_images: Treatment timeline for patient. DM, dermatomyositis; SD, stable disease; PR, partial response; SCC, squamous cell carcinoma antigen; PD, progressive disease.
case_images: fonc-14-1375035-g005.jpg
case_images: PMC11066155_01_fonc-14-1375035-g005.jpg
case_images: f5
case_images: Treatment timeline for patient was shown in ( Figure 5 ).