case_images: PMC5014552_01
case_images: A) Macroscopic tumour: an 8 cm tumour with a myometrial infiltration of more than 50%, reaching the uterine serosa B) H-E 20x: Solid tumoural nests are observed, consisting of small cells with limited cytoplasm.
case_images: can-10-668fig1.jpg
case_images: PMC5014552_01_can-10-668fig1.jpg
case_images: figure1
case_images: At macroscopy an 8 cm tumour, with a myometrial infiltration of more than 50%, reaching the uterine serosa was observed (Figure 1-A). At microscopy with haematoxilin and eosine, lymphovascular embolisation and parametrial stromal infiltration were observed (Figure 1-B).
case_images: A) Neoplastic nest, consisting of small cells with cytoplasmic positivity to chromogranin A. B) : Tumour cells with cytoplasmic positivity to synaptophysin.
case_images: can-10-668fig2.jpg
case_images: PMC5014552_01_can-10-668fig2.jpg
case_images: figure2
case_images: Immunohistochemistry analysis showed synaptophysin++; CD56 +; chromogranin A+ in isolated cells; Ki-67, 80% (Figure 2).
case_images: A) Peritoneal implants, consisting of small cells and IHQ pattern very similar to neuroendocrine primary tumour. B) Lymph nodes metastasis from serous carcinoma with synaptophysin (-) and chromogranin A (-).
case_images: can-10-668fig3.jpg
case_images: PMC5014552_01_can-10-668fig3.jpg
case_images: figure3
case_images: The pathological diagnosis of the peritoneal implants showed metastasis of neuroendocrine tumour, with similar features at immunohistochemical (IHQ) as previously described (Figure 3-A). However, high-grade serous carcinoma with synaptophisin (-) and chromogranin A (-) was diagnosed in 5 out of 13 pelvic lymph nodes and in 20 out of 25 para-aortic lymph nodes (Figure 3-B).