case_images: PMC5439066_01
case_images: Clinical (a) and dermoscopic (b, c) features of the skin alteration. Notable is an asymmetric, irregular brown macula on the plantar side of the right hallux, approximately 15 mm in diameter (a). In dermoscopy, border irregularity and parallel-ridge pattern showing light and dark brown pigmentation with intersecting connection lines being seen (b, c).
case_images: CRIDM2017-3509146.001.jpg
case_images: PMC5439066_01_CRIDM2017-3509146.001.jpg
case_images: fig1
case_images: A 67-year-old healthy female patient without personal or family history of skin cancer presented for skin cancer examination, which revealed an asymmetric, irregular brown macula on the plantar side of the right great toe, approximately 15 mm in diameter (Figure 1(a)). Dermoscopic examination revealed border irregularity and a parallel-ridge pattern showing light and dark brown pigmentation with intersecting connection lines and a partly veiled appearance (Figures 1(b) and 1(c)).
case_images: Histopathology (a) and immunohistochemistry (b) of the surgically removed skin alteration (original magnification x40). Hematoxylin and eosin stain shows thickened orthokeratosis typical for acral skin, sampled stratum corneum with parakeratosis, serosanguinous fluid, and degenerated erythrocytes (a). Immunohistochemical stain for Melan-A revealed regular distribution of basal melanocytes without evidence of malignancy (b).
case_images: CRIDM2017-3509146.002.jpg
case_images: PMC5439066_01_CRIDM2017-3509146.002.jpg
case_images: fig2
case_images: Histopathology revealed thickened orthokeratosis typical for acral skin, sampled stratum corneum with parakeratosis, serosanguinous fluid, and degenerated erythrocytes, consistent with an intracorneal hematoma (Figure 2(a)). Staining for Melan-A showed regular distribution of basal melanocytes without evidence of melanocytic neoplasia (Figure 2(b)).