case_images: PMC10613973_01
case_images: Diagnostic findings. (A, B) H&E section of the trephine biopsy at initial presentation (A) and an illustration of the hemophagocytosis present in this biopsy, indicated by the white arrow (B). (C) CT scan of the thorax performed at initial presentation, which revealed two nodular lesions in the right lung. One nodular lesion with a diameter of 9 mm is shown (white arrow; the other lesion was similar and is not shown). (D) Immunohistochemistry stain of megakaryocytes (CD61, indicated by the purple arrow) in the trephine biopsy collected at 10 days from initial presentation. The clusters with blue cells, indicated by the red arrows, indicate recovering erythropoiesis. (E) Timeline of the most relevant diagnostic findings.
case_images: fimmu-14-1280885-g001.jpg
case_images: PMC10613973_01_fimmu-14-1280885-g001.jpg
case_images: f1
case_images: Furthermore, a BM (trephine) biopsy indicated hemophagocytosis, in line with the activated monocytic population that was detected ( Figures 1A, B ). Subsequently, a high-resolution CT-scan of the thorax showed two small nodular lesions with ground-glass opacity in the lower right lung, but a bronchoalveolar lavage and other diagnostic tests did not reveal any infectious pathogens ( Figure 1C ). Figure 1D ). Furthermore, the monocytic population decreased in abundance, while the lymphoid infiltrate remained extensive. AML-2012 protocol, achieved complete remission, and was transplanted because of high-risk genetics one month ago. A timeline with the most relevant diagnostic findings is presented in  Figure 1E .