case_images: PMC10682171_01
case_images: Sleep onset during screening and Open-Label Extension (OLE). The sleep onset time was significantly improved during the OLE phase as compared to the screening phase (p < 0.0001).
case_images: fnins-17-1287514-g001.jpg
case_images: PMC10682171_01_fnins-17-1287514-g001.jpg
case_images: F1
case_images: DLMO was assessed and determined to be delayed at 23:14, which is significantly later than that of population controls (Supplementary Figure 1). The participant's average sleep onset was 01:27 during screening and 00:42 during the OLE phase, which was a significant improvement (p < 0.0001), as seen in Figure 1.
case_images: Sleep diary data during screening and Open-Label Extension (OLE). Sleep timing (sleep onset, duration, and wake time) was measured by an electronic daily sleep diary over the entire study, screening (green) and OLE (yellow).
case_images: fnins-17-1287514-g002.jpg
case_images: PMC10682171_01_fnins-17-1287514-g002.jpg
case_images: F2
case_images: The participant's sleep diary data during screening and OLE are shown in Figure 2.