case_images: PMC4453162_01
case_images: Magnetic resonance imaging of lower extremities demonstrating a left tibial intramedullary lesion with focal extraosseous extension
case_images: CJ-12-11-g001.jpg
case_images: PMC4453162_01_CJ-12-11-g001.jpg
case_images: F1
case_images: Magnetic resonance imaging of the lower extremities revealed a distal left tibial lesion measuring 11.0 cm x 2.1 cm with focal extraosseous extension [Figure 1].
case_images: Fine-needle aspiration, left leg, Diff-Quik (x200), showing a cellular yield of cohesive, three-dimensional tumor clusters with cellular overlapping and architectural disorder
case_images: CJ-12-11-g002.jpg
case_images: PMC4453162_01_CJ-12-11-g002.jpg
case_images: F2
case_images: The cytologic smears showed a moderately cellular yield, with the tumor arranged mostly in three-dimensional cohesive clusters with cellular overlapping and architectural disorder [Figure 2].
case_images: Fine-needle aspiration, left leg, Diff-Quik (x400), columnar tumor cells arranged in glandular configuration with elongated nuclei, mild to moderate nuclear pleomorphism, and finely dispersed chromatin
case_images: CJ-12-11-g003.jpg
case_images: PMC4453162_01_CJ-12-11-g003.jpg
case_images: F3
case_images: The cells contained elongated nuclei showing mild to moderate nuclear pleomorphism with finely dispersed chromatin and occasional prominent nucleoli [Figure 3].
case_images: (a) Fine-needle aspiration, left leg, cell block preparation with cribriform tumor glands (H and E, x400). (b) Estrogen receptor (x400). (c) Thyroid transcription factor-1 (x400). (d) Paired box gene 8 (x400). (e) Mammaglobin (x400)
case_images: CJ-12-11-g004.jpg
case_images: PMC4453162_01_CJ-12-11-g004.jpg
case_images: F4
case_images: The cell block preparation revealed tumor glands arranged in frequent cribriform structures lined by crowded columnar cells [Figure 4].
case_images: Hysterectomy specimen showing cribriform tumor glands of endometrioid adenocarcinoma infiltrating the myometrium. H and E (x200)
case_images: CJ-12-11-g005.jpg
case_images: PMC4453162_01_CJ-12-11-g005.jpg
case_images: F5
case_images: Microscopic examination confirmed the diagnosis of FIGO grade 2 endometrioid adenocarcinoma, characterized by myoinvasive neoplastic cribriform glands similar to that seen in the patient's bone FNA [Figure 5].