case_images: PMC8096593_01
case_images: Colonoscopy showing submucosal nodularity.
case_images: CRIGM2021-8884820.001.jpg
case_images: PMC8096593_01_CRIGM2021-8884820.001.jpg
case_images: fig1
case_images: This revealed a normal mucosa but diffuse submucosal nodularity through the large intestine (Figure 1).
case_images: Hematoxylin and eosin stain showing lymphoid aggregate with normal colon mucosa.
case_images: CRIGM2021-8884820.002.jpg
case_images: PMC8096593_01_CRIGM2021-8884820.002.jpg
case_images: fig2
case_images: Biopsies were taken from multiple sites, and histopathology of the biopsied revealed multiple aggregates for small mature lymphocytes in the submucosa (Figure 2).
case_images: Lymphoid aggregate positive for PAX5 stain.
case_images: CRIGM2021-8884820.003.jpg
case_images: PMC8096593_01_CRIGM2021-8884820.003.jpg
case_images: fig3
case_images: Immunohistochemical stains revealed neoplastic lymphocytes positive for PAX5 (Figure 3), BCL-2, dim BCL-6, CD5, partial CD20, and CD23 and negative for CD3, cyclin D1 (Figure 4), and CD10.
case_images: Lymphoid aggregate negative for cyclin D1.
case_images: CRIGM2021-8884820.004.jpg
case_images: PMC8096593_01_CRIGM2021-8884820.004.jpg
case_images: fig4
case_images: Immunohistochemical stains revealed neoplastic lymphocytes positive for PAX5 (Figure 3), BCL-2, dim BCL-6, CD5, partial CD20, and CD23 and negative for CD3, cyclin D1 (Figure 4), and CD10.