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case_images: The images of CT scan of the patient. The patient received ten cycles of maintenance therapy with durvalumab between July 2021 and April 2022. (A) CT scan of the patient on March 10, 2021 showed massive shadow in the middle and lower lobes of the right lung near the hilar area (B) CT scan of the patient on September 25, 2021 showed significant reduction in primary tumor size (C) CT scan of the patient on February 28, 2022 showed reduction in primary tumor size (D) CT scan of the patient on August 17, 2022 showed no definite tumor recurrence or metastasis (E) CT scan of the patient on February 21, 2023 showed no definite tumor recurrence or metastasis. (F) CT scan of the patient on August 15, 2023 showed no definite tumor recurrence or metastasis.
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case_images: After the computed tomography (CT) scan of the chest (Figure 1A), lesions biopsy by electronic bronchoscopy (Figure 2A) and positron emission tomography (PET)/CT scan (Figure 2B), he was diagnosed with limited-stage SCLC. Fortunately, according to the CT scan (Figure 1D), there was no progression of cancer after the end of immune maintenance treatment. There is no recurrence or metastasis of the primary tumor after the administration of chemotherapy plus immunotherapy during regular follow-up (Figure 1E and F), though this patient had been diagnosed with SCLC for more than two years.
case_images: (A) Lesions biopsy by electronic bronchoscopy (B) The image of positron emission tomography (PET)/CT scan showed abnormal soft tissue density in the middle and lower lobes of the right lung near the hilar region with adjacent bronchial stenosis and occlusion, and abnormal concentration of radioactivity distribution in the corresponding area, SUVmax 6.8.
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case_images: After the computed tomography (CT) scan of the chest (Figure 1A), lesions biopsy by electronic bronchoscopy (Figure 2A) and positron emission tomography (PET)/CT scan (Figure 2B), he was diagnosed with limited-stage SCLC.
case_images: Widespread areas of skin sclerosis of the patient. (A) Chest and Abdomen (B) Back (C) Chest, Abdomen and Upper Limbs (D) Neck.
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case_images: However, the patient gradually felt slight swelling and tightness of the skin on his trunk and limbs accompanied by skin itching after ten cycles of durvalumab maintenance therapy (Figure 3).
case_images: Hematoxylin-eosin (HE) staining of the pathology slide showing the dermis is generally normal, with coarse reddish staining of the deep dermal collagen proliferation, upward displacement of the small sweat glands and visible extrusion, and infiltration of lymphocytes, histiocytes, and a small number of plasma cells seen around the blood vessels and subcutaneous lobules (A) HE, 40X; (B) HE, 100X.
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case_images: After skin biopsy of the lesion on the right abdomen, histopathologic examination was reported as systemic sclerosis (Figure 4).