case_images: PMC6136481_01
case_images: A midline lesion involving the dorsal surface of the patient's tongue.
case_images: CRID2018-4162436.001.jpg
case_images: PMC6136481_01_CRID2018-4162436.001.jpg
case_images: fig1
case_images: On examination, a 1.5 cm diameter exophytic midline tongue lesion (Figure 1) was noted.
case_images: Lingual leiomyomatous hamartoma as seen on magnetic resonance imaging.
case_images: CRID2018-4162436.002.jpg
case_images: PMC6136481_01_CRID2018-4162436.002.jpg
case_images: fig2
case_images: A magnetic resonance image (MRI) of his tongue was obtained (Figure 2).
case_images: (a) Section of the hamartoma showing fascicles of smooth muscles, fat, and salivary glands, with normal covering epithelium (haematoxylin and eosin, original magnification x10). (b) Section of the hamartoma showing blood vessels, fascicles of smooth muscles, fat, and salivary glands (haematoxylin and eosin, original magnification x200). (c) High-power section of the hamartoma showing fascicles of smooth muscles and fat. (haematoxylin and eosin, original magnification x400).
case_images: CRID2018-4162436.003.jpg
case_images: PMC6136481_01_CRID2018-4162436.003.jpg
case_images: fig3
case_images: In this specimen, microscopy revealed circumscribed nodules covered by stratified squamous epithelium, and interlacing cords of eosinophilic spindle-shaped cells consistent with the smooth muscle within the lamina propria (Figures 3(a)-3(c)).
case_images: Immunohistochemical findings of a section of the hamartoma showing fascicles of smooth muscles with smooth-muscle actin immunoreactivity (original magnification x100).
case_images: CRID2018-4162436.004.jpg
case_images: PMC6136481_01_CRID2018-4162436.004.jpg
case_images: fig4
case_images: Immunostaining for alpha-smooth-muscle actin demonstrated large concentrations of smooth-muscle bundles; however, S-100 was found only in peripheral nerve bundles intermingled with smooth-muscle fibers (Figures 4 and 5).
case_images: Immunohistochemical findings of a section of the hamartoma showing low S100 immunoreactivity (original magnification x100).
case_images: CRID2018-4162436.005.jpg
case_images: PMC6136481_01_CRID2018-4162436.005.jpg
case_images: fig5
case_images: Immunostaining for alpha-smooth-muscle actin demonstrated large concentrations of smooth-muscle bundles; however, S-100 was found only in peripheral nerve bundles intermingled with smooth-muscle fibers (Figures 4 and 5).