case_images: PMC3518093_01
case_images: Bone metastasis in the sternoclavicular joint invading adjacent soft tissues.
case_images: CRIM.ONCMED2012-509845.001.jpg
case_images: PMC3518093_01_CRIM.ONCMED2012-509845.001.jpg
case_images: fig1
case_images: The thoracoabdominal CT scan revealed an osteolytic sternoclavicular joint mass (Figure 1) and 3 liver metastases.
case_images: Partial response after radiotherapy and 10 months of imatinib with partial reossification in the sternoclavicular joint and decreasing of the soft tissue extension.
case_images: CRIM.ONCMED2012-509845.002.jpg
case_images: PMC3518093_01_CRIM.ONCMED2012-509845.002.jpg
case_images: fig2
case_images: Control contrast-enhanced CT scans showed a partial response in bone lesion (Figure 2) as well as in liver metastases.
case_images: Bone scintigraphy image showing increasing intensity of tracer uptake localized in the sternoclavicular joint.
case_images: CRIM.ONCMED2012-509845.003.jpg
case_images: PMC3518093_01_CRIM.ONCMED2012-509845.003.jpg
case_images: fig3
case_images: Bone scintigraphy showed an increasing intensity of tracer uptake localized in the sternoclavicular joint (Figure 3).
case_images: Bone marrow biopsy: Spindle cells with high cellularity. Some of the tumor cells show mild pleomorphism. Numerous mitotic figures are present ( ) (hematoxylin and eosin: x400).
case_images: CRIM.ONCMED2012-509845.004.jpg
case_images: PMC3518093_01_CRIM.ONCMED2012-509845.004.jpg
case_images: fig4
case_images: The histological features and staining pattern of the tumor cells were consistent with a GIST metastasis (Figures 4 and 5).
case_images: Positive immunostaining with c-Kit (CD117). Note diffuse membranous pattern (HE x400).
case_images: CRIM.ONCMED2012-509845.005.jpg
case_images: PMC3518093_01_CRIM.ONCMED2012-509845.005.jpg
case_images: fig5
case_images: Immunohistochemical staining demonstrated the tumor cells to be positive for c-kit (CD117) (Figure 5) protein and CD34 protein. The histological features and staining pattern of the tumor cells were consistent with a GIST metastasis (Figures 4 and 5).