case_images: PMC11150661_01
case_images: (A) CT chest with 1.4 cm right middle lobe spiculated nodule at time of initial diagnosis. (B) PET/CT demonstrating absence of increased FDG activity in the prostate gland at time of diagnosis. (C) Increased FDG activity in the prostate gland with maximum standardized uptake value (SUV) 8.4 concerning for prostatic metastasis. (D) Decreased FDG activity in prostate gland following SBRT with SUV max 3.6.
case_images: fonc-14-1394168-g002.jpg
case_images: PMC11150661_01_fonc-14-1394168-g002.jpg
case_images: f2
case_images: Imaging of the neck showed multiple slightly enlarged right cervical nodes and right axillary nodes, as well as a 1.4 cm right middle lobe (RML) spiculated nodule ( Figure 2A ). PET/CT demonstrated absence of increased signal activity in other organs, including the prostate gland (Figure 2B). PET/CT 1.5 years following initial diagnosis revealed interval enlargement of the RLL opacity consistent with post-radiation changes and a new hypermetabolic focus in the left prostate concerning for malignant process at both locations ( Figure 2C ). Prostate Specific He completed 16 months of BV with continuous complete metabolic response of his lymphoma on post-treatment PET/CT ( Figure 2D ).
case_images: (A) Prostate biopsy. Poorly differentiated pulmonary adenocarcinoma infiltrating between benign prostate glands. (B, C). Prostate biopsy immunohistochemistry stains. Positive for TTF1 [B], CK7, AE1/3 (not shown) and negative for NKX3.1[C] and Napsin-A (not shown). (D) Right middle lobe biopsy. Invasive pulmonary adenocarcinoma. Positive for TTF-1, Napsin-1, and negative for p40 (not shown).
case_images: fonc-14-1394168-g003.jpg
case_images: PMC11150661_01_fonc-14-1394168-g003.jpg
case_images: f3
case_images: Tumor cells were positive for TTF1, CK7, AE1/3 and negative for NKX3, suggestive of metastatic lung adenocarcinoma ( Figure 3 ).