case_images: PMC11111966_01
case_images: The timeline of case 1 (A) and case 2 (B) with scrub typhus-associated HLH. Major events during the course of the patient's illness are described in the line by a different color. Black means deterioration of the disease, red signifies ineffective drug treatment, underlining denotes the turning point, and green represents recovery.
case_images: fpubh-12-1321123-g001.jpg
case_images: PMC11111966_02_fpubh-12-1321123-g001.jpg
case_images: fig1
case_images: The timeline of case 2 is shown in Figure 1B.
case_images: Clinical laboratory examination values during both patients' hospitalization. C-reactive protein (CRP, green line) and body temperature (black line) were quickly decreased, as well as the serum ferritin line was excluded in this figure. the blood platelet (PLT, red line) was increased obviously own to the treatment of doxycycline.
case_images: fpubh-12-1321123-g002.jpg
case_images: PMC11111966_02_fpubh-12-1321123-g002.jpg
case_images: fig2
case_images: The laboratory findings of PLT, CRP, and body temperature during her hospitalization are shown in Figure 2B. September 2023). Subsequently, following a 10-day treatment period, the patient's body temperature and platelet count gradually normalized by 15 September 2023 (Figure 2B).
case_images: Confirmation of Ot in the plasma sample from both patients (A,C representing case 1 and B,D representing case 2) by mNGS. A,B show the reads mapped to Ot derived from mNGS data. C,D show the distribution of pathogenic microorganism reads in the absence of human, others, and unclassified reads. A total of 318 and 11,387 reads mapped to Ot in the reference database which contains about 8,000 pathogen genomes.
case_images: fpubh-12-1321123-g003.jpg
case_images: PMC11111966_02_fpubh-12-1321123-g003.jpg
case_images: fig3
case_images: After 24 h, on 5 September 2023, the analysis revealed a total of 11,387 sequences of Ot, with a genome coverage and relative abundance of 25.12 and 99.12%, respectively (Figures 3B,D).
case_images: PMC11111966_02
case_images: The timeline of case 1 (A) and case 2 (B) with scrub typhus-associated HLH. Major events during the course of the patient's illness are described in the line by a different color. Black means deterioration of the disease, red signifies ineffective drug treatment, underlining denotes the turning point, and green represents recovery.
case_images: fpubh-12-1321123-g001.jpg
case_images: PMC11111966_02_fpubh-12-1321123-g001.jpg
case_images: fig1
case_images: The timeline of case 2 is shown in Figure 1B.
case_images: Clinical laboratory examination values during both patients' hospitalization. C-reactive protein (CRP, green line) and body temperature (black line) were quickly decreased, as well as the serum ferritin line was excluded in this figure. the blood platelet (PLT, red line) was increased obviously own to the treatment of doxycycline.
case_images: fpubh-12-1321123-g002.jpg
case_images: PMC11111966_02_fpubh-12-1321123-g002.jpg
case_images: fig2
case_images: The laboratory findings of PLT, CRP, and body temperature during her hospitalization are shown in Figure 2B. September 2023). Subsequently, following a 10-day treatment period, the patient's body temperature and platelet count gradually normalized by 15 September 2023 (Figure 2B).
case_images: Confirmation of Ot in the plasma sample from both patients (A,C representing case 1 and B,D representing case 2) by mNGS. A,B show the reads mapped to Ot derived from mNGS data. C,D show the distribution of pathogenic microorganism reads in the absence of human, others, and unclassified reads. A total of 318 and 11,387 reads mapped to Ot in the reference database which contains about 8,000 pathogen genomes.
case_images: fpubh-12-1321123-g003.jpg
case_images: PMC11111966_02_fpubh-12-1321123-g003.jpg
case_images: fig3
case_images: After 24 h, on 5 September 2023, the analysis revealed a total of 11,387 sequences of Ot, with a genome coverage and relative abundance of 25.12 and 99.12%, respectively (Figures 3B,D).