case_images: PMC10833225_01
case_images: US, CT, and MRI images of SCCT. (A) (US) Eggshell-shaped calcification on the surface of the nodule; internal echoes are unavailable; (B) (US) Ring-shaped calcifications within the nodule; (C) (US) Punctate calcification within the nodule; (D) (US) Hypoechoic nodule with unclear borders, breaking through the thyroid peritoneum and invading the surrounding tissue; (E) (CT) Uneven moderate enhancement of the nodules, the esophagus and trachea were compressed and displaced, and the boundary was unclear; (F) (CT) The mass compresses and infiltrates the trachea and surrounding soft tissues; (G) (CT) Partial necrosis of the mass in the left lobe of the thyroid infiltrating adjacent skin and trachea; (H) (MRI) Uneven enhancement of the left lobe of the thyroid, with unclear boundaries with the esophagus, trachea, and left common carotid artery.
case_images: fendo-14-1273472-g001.jpg
case_images: PMC10833225_01_fendo-14-1273472-g001.jpg
case_images: f1
case_images: Most approach or break through the thyroid envelope ( Figure 1D ). Regarding calcification, some patients had a few trace calcifications, eggshell-like calcifications, or discontinuous circular calcifications within the mass ( Figures 1A-C ). It can also evaluate the adjacent larynx and trachea to identify migration, luminal narrowing, and invasion ( Figures 1E-H ).
case_images: Pathological images of SCCT. (A) At low magnification, the cancerous tissues are in the form of striated, nested, and sheet-like structures, closely arranged, with deeply stained nuclei and numerous nuclear schizophrenic images, x100; (B) at high magnification, the formation of keratinized beads, highly stained nuclei, eosinophilic nucleoli and abundant eosinophilic cytoplasm can be seen, x400; (C) perineural invasion; (D) lymphovascular invasion; (E) CK19 (+); (F) Ki-67 proliferation index of about 30%; (G) TTF1 (+); (H) P63 (+); (I) CK5/6 (+); (J) TG (+); (K) PAX8 is moderately positive; (L) p40 (+).
case_images: fendo-14-1273472-g002.jpg
case_images: PMC10833225_01_fendo-14-1273472-g002.jpg
case_images: f2
case_images: Microscopically, the tumor cells were arranged in a nested pattern, and the typical morphological changes of squamous carcinomas, such as intercellular bridges, keratinized beads, and single-cell keratinization, could be seen ( Figures 2A, B ). Peripheral nerves and lymphatic vessel infiltration are sometimes seen ( Figures 2C, D ).