case_images: PMC10010164_01
case_images: Postoperative pathology of gastric carcinoma in 2015.
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case_images: PMC10010164_01_fonc-13-1105080-g001.jpg
case_images: f1
case_images: The postoperative histopathology of the primary lesion was mixed invasive adenocarcinoma, of which signet-ring cell carcinoma accounted for 80%, and tubular adenocarcinoma accounted for 20% ( Figure 1 ).
case_images: Cutaneous metastatic carcinomas. (A) Beaded mass in left groin area and erythematous scleroderma of the left thigh; (B, C) Two fleshy masses on the scalp.
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case_images: PMC10010164_01_fonc-13-1105080-g002.jpg
case_images: f2
case_images: A physical examination revealed moderate pitting edema of the left lower extremity, redness and swelling of the thigh with scleroderma-like changes, bead-like nodules of about 5*20cm in the groin area ( Figure 2A ), and two fleshy masses of about 3*3cm in size on the scalp ( Figures 2B, C ).
case_images: Skin biopsy of the groin mass; the pathology showed metastatic poorly differentiated carcinoma, some of which were signet-ring cell carcinoma.
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case_images: PMC10010164_01_fonc-13-1105080-g003.jpg
case_images: f3
case_images: A skin biopsy was performed on the groin mass, and the pathology showed metastatic poorly differentiated carcinoma, some of which were signet-ring cell carcinoma; immunohistochemical staining showed: PCK(+), CK7(+), CK20(-), CDX2(+), SATB2(-), and HER2(0) ( Figure 3 ).
case_images: PET-CT examination. (A) Multiple humus-like hypodense nodules on the skin surface from the left groin to the thigh, secondary lymphedema, and slightly increased metabolic diffusion; (B) Localized thickening of the skin on the top of the left head and back of the neck and slightly increased metabolism.
case_images: fonc-13-1105080-g004.jpg
case_images: PMC10010164_01_fonc-13-1105080-g004.jpg
case_images: f4
case_images: A whole-body PET-CT examination showed multiple humus-like hypodense nodules on the skin surface from the left groin to the thigh, secondary lymphedema, and slightly increased metabolic diffusion ( Figure 4A ). The above suggested the possibility of malignant tumor metastatic lesions ( Figure 4B ).