case_images: PMC10481794_01
case_images: Axial (a) and coronal (b) sequences of computed tomography brain without contrast showing a heterogeneously dense mass within the corpus callosum, with surrounding vasogenic edema in the bilateral frontal lobes. R: Right. L: Left.
case_images: SNI-14-275-g001.jpg
case_images: PMC10481794_01_SNI-14-275-g001.jpg
case_images: F1
case_images: A computed tomography (CT) scan was obtained which demonstrated vasogenic edema the bilateral frontal lobes with involvement of the corpus callosum, and evidence of an ill-defined mass centered in the corpus callosum above the anterior horns of the lateral ventricles [Figure 1].
case_images: Axial (a) and coronal (b) sequences of magnetic resonance image brain with contrast demonstrating a heterogeneously enhancing lesion crossing the corpus callosum in the bilateral frontal lobes and cingulate gyrus. RPF: Right. LAH: Left.
case_images: SNI-14-275-g002.jpg
case_images: PMC10481794_01_SNI-14-275-g002.jpg
case_images: F2
case_images: (a) Microscopic examination reveals a hypercellular epithelioid neoplasm with abundant mitotic activity in a background of necrosis. Focal areas of tumor cells demonstrate clear cytoplasm with distinct cell borders, consistent with glycogenation (inset). (b) Immunohistochemical staining reveals the tumor cells are positive for p16 (upper left), p40 (upper right), and estrogen receptor (lower left). The tumor cells are negative for PAX8 and progesterone receptor. Histochemical staining with mucicarmine is negative for any intracellular mucin (lower right). The overall findings are consistent with metastatic HPV-dependent squamous cell carcinoma. (a) Hematoxylin and eosin, x4 (inset: x20). (b) Hematoxylin and eosin, x10.
case_images: SNI-14-275-g003.jpg
case_images: PMC10481794_01_SNI-14-275-g003.jpg
case_images: F3
case_images: The histopathology and immunohistochemistry were consistent with a metastatic lesion from the patient's known cervical adenosquamous carcinoma [Figure 3].
case_images: Axial (a) and coronal (b) sequences of computed tomography brain without contrast status post right frontal craniotomy demonstrating expected postoperative changes of open biopsy and partial resection of callosal mass. AHL: Anterior. RAH: Right. LPF: Left. PFR: Posterior. HLP: Superior. FRA: Inferior.
case_images: SNI-14-275-g004.jpg
case_images: PMC10481794_01_SNI-14-275-g004.jpg
case_images: F4
case_images: The patient recovered well from the surgery, a CT scan showed expected postoperative changes [Figure 4], and she was discharged in stable condition and was treated subsequently with external beam radiation to the whole brain.
case_images: Axial (a) and coronal (b) sequences of follow-up magnetic resonance image brain with contrast 3-month postoperatively demonstrating interval decreased size of enhancing mass centered within the corpus callosum body and thin marginal enhancement along the biopsy tract, favored to represent postsurgical change. RHA: Right. LFP: Left. AHL: Anterior. PFR: Posterior.
case_images: SNI-14-275-g005.jpg
case_images: PMC10481794_01_SNI-14-275-g005.jpg
case_images: F5
case_images: Due to persistent disease on follow-up MRI [Figure 5], she additionally received stereotactic radiation treatment, and at 3-month follow-up, she remains intact and continues to receive radiation treatment.