case_images: PMC10867103_01
case_images: Timeline of patient symptoms, interventions, and BMI. Wk, week.
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case_images: PMC10867103_01_fonc-14-1189287-g001.jpg
case_images: f1
case_images: She then transitioned to AI therapy with anastrozole in July 2020 when she was felt to be in menopause with multiple ultrasensitive estradiol levels<15 pg/mL ( Figure 1 ). Figure 1 ). Finally, she began using a CGM (Dexcom G6) to help lower daylong glucose and guide selection of lower glycemic index (GI) foods with less impact on postprandial glucose. She found that the same quantity of the same batch of cooked sweet potato would produce a less pronounced increase in blood glucose if she engaged in 20-30 minutes of moderate aerobic exercise (i.e., brisk walking or trampoline) before or after her meal or if she ate a portion of lean protein before consuming the sweet potato ( Supplementary Figure 1 ). Her Achilles tenosynovitis fully resolved and the nodule was no longer palpable, concordant with a substantial increase in her exercise patterns (daily step counts and calories burned in her Peloton workouts,  Figure 1 ).
case_images: Summary characteristics of the patient's dietitian-guided diet pattern with recommended macronutrient breakdown and examples of typical meals consumed by the patient.
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case_images: f2
case_images: Supplementary Figure 2 ). She reported enrolling in a dietitian-supervised program most closely approximating a Mediterranean plant-forward diet with high intake of olive oil, fruits and vegetables, and less than 20% fish, poultry, or meat alternatives rather than red and/or processed meats and stated that she achieved her macronutrient goals (20% protein, 45% carbohydrates, 35% fat) over 90% of the time ( Figure 2 ). HgbA1C improved from 6.3 to 5.8% between December 2021 and August 2022. Her hepatic steatosis fully resolved by January 2023 ( Supplementary Figure 2 ).
case_images: Integrated Nested Laplacian Approximation (INLA) model of (A) mean glucose values, (B) within-day variance in blood glucose values (), and (C) fraction of CGM readings within target glucose range. Shaded area represents 95% confidence interval. Dotted line represents overall mean for the dataset.
case_images: fonc-14-1189287-g003.jpg
case_images: PMC10867103_01_fonc-14-1189287-g003.jpg
case_images: f3
case_images: CGM data reveal trends toward reduced glucose variability and increased time in the target range (70-140 mg/dL) ( Figure 3 ). Consistent with these changes, her