case_images: PMC10525323_01
case_images: Brain MRI. (A) Initial primary tumor. A heterogeneously enhancing tumor on the left frontal lobe (32 x 29 x 31 mm3) with an associated mass effect. (B) Metastasis. Three well-defined, heterogeneously enhanced tumors in the left upper frontal lobe with found (39 x31 x42 mm3, 34 x34 x 31 mm3, 13 x8 x 14 mm3) with associated mass effect, with surrounding edema.
case_images: fonc-13-1222961-g001.jpg
case_images: PMC10525323_01_fonc-13-1222961-g001.jpg
case_images: f1
case_images: The initial magnetic resonance imaging (MRI) of the brain revealed a heterogeneously enhanced tumor on the left frontal lobe with an associated mass effect, and the enhanced MRI scan showed a dural tail sign ( Figure 1 ). MRI revealed 3 well-defined, heterogeneously enhanced tumors in the left upper frontal lobe with associated mass effect, surrounding edema, thickened meningeal enhancement, and the dural tail sign ( Figure 1 ). MRS detected a significantly heightened Cho peak and a normal NAA peak.
case_images: Hematoxylin and eosin (H&E) staining and immunostaining of specimens from the resected mass. (A) H&E revealed medullary small cells with scant cytoplasm, hyperchromatic nuclei, and numerous mitoses. (B-E) Immunohistochemistry showed positivity for (B) CD56, (C) Syn, (D) CK, and (E) Ki-67.
case_images: fonc-13-1222961-g002.jpg
case_images: PMC10525323_01_fonc-13-1222961-g002.jpg
case_images: f2
case_images: Histopathological analysis of the excised tissue showed medullary small cells with scant cytoplasm, hyperchromatic nuclei, and numerous mitoses ( Figure 2 ).
case_images: H&E staining and immunostaining of specimens from the resected mass (metastasis). (A) H&E staining. (B-F) Immunohistochemistry showed positivity for (B) CD56, (C) Syn, (D) CK, (E) CgA, and (F) Ki-67.
case_images: fonc-13-1222961-g003.jpg
case_images: PMC10525323_01_fonc-13-1222961-g003.jpg
case_images: f3
case_images: TTF-1, NSE, Napsin A, and S-100 ( Figure 3 ). This indicated the recurrence of the intracranial SCC in the left frontal lobe.