case_images: PMC10839418_01
case_images: Dark red diffuse patch/plaque erythroderma sparing the skin folds..  There is increased superficial epidermal desquamation evident. Dark brown to black macules diffusely present across back within areas affected by patches.
case_images: cureus-0016-00000051707-i01.jpg
case_images: PMC10839418_01_cureus-0016-00000051707-i01.jpg
case_images: FIG1
case_images: The patient stated that immediately after taking the first dose of amoxicillin, she broke out a diffuse rash over her chest and proximal arms associated with itching and burning (Figure 1).
case_images: Superficial perivascular inflammatory infiltrate mainly composed of lymphocytes with eosinophils. Hematoxylin and eosin (H&E) 5x.
case_images: cureus-0016-00000051707-i02.jpg
case_images: PMC10839418_01_cureus-0016-00000051707-i02.jpg
case_images: FIG2
case_images: Skin punch biopsies of the upper extremities, right abdomen, and right thigh were done, and pathology report depicted predominantly lymphocytic dermal inflammatory infiltrates with scattered eosinophils consistent with a drug eruption (Figures 2, 3).
case_images: Epidermal dyskeratosis with diffuse vacuolar interface dermatitis in DRESS. Hematoxylin and eosin (H&E) 20x.
case_images: cureus-0016-00000051707-i03.jpg
case_images: PMC10839418_01_cureus-0016-00000051707-i03.jpg
case_images: FIG3
case_images: Skin punch biopsies of the upper extremities, right abdomen, and right thigh were done, and pathology report depicted predominantly lymphocytic dermal inflammatory infiltrates with scattered eosinophils consistent with a drug eruption (Figures 2, 3).