case_images: PMC7874168_01
case_images: Family pedigree.
case_images: fneur-11-591395-g0001.jpg
case_images: PMC7874168_01_fneur-11-591395-g0001.jpg
case_images: F1
case_images: Moreover, proband's only 8-year-old male child is affected by a classical FMF phenotype with recurrent serositis and self-limiting fever attacks (Figure 1).
case_images: Brain and spinal cord MRI. Brain MRI images (Fluid Attenutated Inversion Recovery coronal and axial projections, Double Inversion Recovery sagittal projection) showing typical MS lesions involving bi-hemispheric white matter (A). Cervical MRI image (Short Time Inversion Inversion Recovery and T1-gd+ sagittal projection) at diagnosis (B) showing a C2-C3 level lesion with gd-enhancement (arrow), resolution after steroid treatment (C) and stability at 4-month follow-up after two cycles of Rituximab (D).
case_images: fneur-11-591395-g0002.jpg
case_images: PMC7874168_01_fneur-11-591395-g0002.jpg
case_images: F2
case_images: He performed a brain and spinal cord MRI, which showed multiple supra- and infratentorial lesions (Figure 2A) and a gadolinium-enhancing lesion in the cervical spinal cord at right lateral C2-C3 level responsible for symptoms (Figure 2B). One month-follow up MRI was stable in terms of lesion burden, and the cervical lesion no longer showed gd-enhancement (Figure 2C). No additional lesions were detected at last brain and cervical spinal cord MRI performed in 6/2020 (Figure 2D).