case_images: PMC3934780_01
case_images: a Facial skin xerosis. b Large rhomboidal scales covering most of the body. c Dry skin with rhomboidal scales on the lower extremities. d Plantar hyperkeratosis.
case_images: cde-0006-0010-g01.jpg
case_images: PMC3934780_01_cde-0006-0010-g01.jpg
case_images: F1
case_images: On physical examination, she had generalized xerosis with large rhomboidal scales covering most of her body and scalp, painful stomatitis and palmar and plantar hyperkeratosis (fig. 1a-d).
case_images: a Hyperorthokeratosis, absence of granular layer and reduced rete-papilla pattern (HE, x40). b Osseous HP.
case_images: cde-0006-0010-g02.jpg
case_images: PMC3934780_01_cde-0006-0010-g02.jpg
case_images: F2
case_images: A skin biopsy was performed, which confirmed the clinical diagnosis of AI by revealing hyperorthokeratosis and an absence of granular layers (fig. 2a). The CT scan revealed a multilobular tumor mass in the minor pelvis, infiltrating the sacrum and perirectal space and spreading to the lower lumbar muscles (HP recurrence) (fig. 2b).