case_images: PMC5457633_01
case_images: Microscopic appearance of a fine-needle aspiration biopsy and cytological examination of the thyroid. Follicular cells are arranged as sheets, compatible with the smear of a nodular goiter. (Papanicolaou, x40)
case_images: 12907_2017_48_Fig1_HTML.jpg
case_images: PMC5457633_01_12907_2017_48_Fig1_HTML.jpg
case_images: Fig1
case_images: A fine-needle aspiration biopsy and cytological examination of the mass revealed follicular cells arranged as sheets or follicles, and hemosiderin-laden macrophages, compatible with the smear of a nodular goiter (Fig. 1).
case_images: Macroscopic appearance of a nodule in thyroid tissue. The cut surface revealed a lobulated, infiltrating, and solid gray-whitish tumor, with a thick, focal capsule. Dots outline the poorly differentiated carcinoma component and the arrowheads indicate the nodular goiter
case_images: 12907_2017_48_Fig2_HTML.jpg
case_images: PMC5457633_01_12907_2017_48_Fig2_HTML.jpg
case_images: Fig2
case_images: When cut, the nodule's surface showed a lobulated, infiltrating, and solid gray-whitish tumor with a thick, focal capsule (Fig. 2).
case_images: Microscopic appearance of a nodule in thyroid tissue. A widely invasive, cellular tumor (asterisks), with a nodular goiter (arrowhead) within a nodule partially encapsulated by a thick fibrous capsule (cap) was noted. (hematoxylin and eosin, x1.25)
case_images: 12907_2017_48_Fig3_HTML.jpg
case_images: PMC5457633_01_12907_2017_48_Fig3_HTML.jpg
case_images: Fig3
case_images: Microscopically, a widely invasive, cellular tumor (Fig. 3) was observed, with tumor cells lacking the nuclear features of a papillary thyroid carcinoma and arranged in trabecular, solid, and microfollicular histological patterns (Fig. 4a).
case_images: The poorly differentiated thyroid carcinoma showed trabecular, solid and microfollicular histological patterns without the nuclear features of a papillary thyroid carcinoma a, as well as high mitotic activity b. (a-b: hematoxylin and eosin, a: x10, b: x20)
case_images: 12907_2017_48_Fig4_HTML.jpg
case_images: PMC5457633_01_12907_2017_48_Fig4_HTML.jpg
case_images: Fig4
case_images: A mitotic activity of four mitoses per 10 high-power fields was noted (Fig. 4b).
case_images: The nodular goiter was composed of small or dilated follicles, and lacked the nuclear features of a papillary thyroid carcinoma. (hematoxylin and eosin, x10)
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case_images: PMC5457633_01_12907_2017_48_Fig5_HTML.jpg
case_images: Fig5
case_images: The residual thyroid showed a nodule partially encapsulated by a thick fibrous capsule, and composed of small or dilated follicles but without papillary carcinoma-like nuclear characteristics (Fig. 5).
case_images: The Ki-67 labeling index of the nodular goiter was very low a; however, that of the PDTC was high b. (Ki-67 immunostain, a-b: x10)
case_images: 12907_2017_48_Fig6_HTML.jpg
case_images: PMC5457633_01_12907_2017_48_Fig6_HTML.jpg
case_images: Fig6
case_images: TTF-1 and PAX-8, and was sparsely scattered, with immunoreactive staining for thyroglobulin and p53 present. The Ki-67 labeling index of the nodular goiter was very low (1.4%; Fig. 6a); however, that of the PDTC was high (20.5%; Fig. 6b). The proportion of PDTC area within the nodular goiter was approximately 50%.