case_images: PMC6362748_01
case_images: (a and b) Multiple erythematous papules over the face. (c) Multiple erythematous papules and edematous urticarial plaques over the back. (d) Purpuric lesion over the thenar aspect of right palm
case_images: IDOJ-10-61-g001.jpg
case_images: PMC6362748_01_IDOJ-10-61-g001.jpg
case_images: F1
case_images: On cutaneous examination, multiple erythematous papules, edematous urticarial plaques and purpuric lesions of varying sizes were present over the face, neck, trunk, upper, and lower extremities [Figure 1a-d].
case_images: (a) Moderately dense perivascular and interstitial infiltrate of lymphocytes, eosinophils, and neutrophils with spongiosis in the superficial and mid-dermis. (Hand E staining, x10). (b) Interstitial infiltrate of many mature eosinophils intermixed with neutrophilswith areas of leukocytoclasia without vasculitis (Hand E staining, x40)
case_images: IDOJ-10-61-g002.jpg
case_images: PMC6362748_01_IDOJ-10-61-g002.jpg
case_images: F2
case_images: Sweet's syndrome. Skin biopsy with hematoxylin and eosin stain found wedge-shaped moderately dense perivascular and interstitial infiltrate of many mature eosinophils intermixed with neutrophils in the superficial and mid-dermis with areas of leukocytoclasia without any evidence of vasculitis [Figure 2a and b].
case_images: (a and b) Resolution of facial lesions after treatment. (c) Significant decrease in the number and size of lesions after treatment. (d) Clearance of palmar lesion after treatment
case_images: IDOJ-10-61-g003.jpg
case_images: PMC6362748_01_IDOJ-10-61-g003.jpg
case_images: F3
case_images: Simultaneously, the intensity of pruritus decreased with significant reduction in the number and size of lesions during each eruption [Figure 3a-d].