case_images: PMC6090953_01
case_images: Case report timeline
case_images: 12907_2018_73_Fig1_HTML.jpg
case_images: PMC6090953_01_12907_2018_73_Fig1_HTML.jpg
case_images: Fig1
case_images: An 80-year-old Arabian female presented to our hospital with a 2-month history of swelling over the right eyebrow, pain, proptosis of the right eye and diplopia (Fig. 1).
case_images: Histological aspect of the lesion in biopsy: a The tumour is composed of interlacing bundles of spindle cells (H&E x 100). b The neoplastic cells show anisokaryosis and hyperchromatic nuclei (H&E x 400)
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case_images: PMC6090953_01_12907_2018_73_Fig2_HTML.jpg
case_images: Fig2
case_images: On microscopic examination, the tumour was composed of interlacing bundles of spindle cells with anisokaryosis and hyperchromatic nuclei (Fig. 2).
case_images: Gross features of the exenterated orbital contents: Cut surface shows ill-defined, whitish and firm tumour. It is attached to the sclera without infiltration into eyeball. It infiltrates the upper eyelid. The tumour is extending to the surgical margins
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case_images: PMC6090953_01_12907_2018_73_Fig3_HTML.jpg
case_images: Fig3
case_images: It infiltrated the upper eyelid (Fig. 3).
case_images: Histological aspect of the tumour after orbital exenteration: a Neoplastic spindle cells are arranged in disorganized fascicules (H&E x 100). b The tumour is attached to the sclera without infiltration (H&E x 40). c Infiltration into adipose tissue and striated muscle is observed (H&E x 40). d High-power view shows the obvious cytologic atypia and several mitoses of the neoplastic cells (H&E x 400)
case_images: 12907_2018_73_Fig4_HTML.jpg
case_images: PMC6090953_01_12907_2018_73_Fig4_HTML.jpg
case_images: Fig4
case_images: Adipose tissue and striated muscle infiltration was observed (Fig. 4).
case_images: Immunohistochemical profile of the tumour after orbital exenteration: The tumor cells express pancytokeratin AE1/AE3 a, EMA b, SMA (c) and express focally S100 protein (d)
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case_images: PMC6090953_01_12907_2018_73_Fig5_HTML.jpg
case_images: Fig5
case_images: It revealed diffuse positive staining for pancytokeratin AE1/AE3, EMA and SMA and focal positivity for S100 protein (Fig. 5).
case_images: Immunohistochemical profile of the tumour after orbital exenteration: The tumor cells are negative for desmin (a) (infiltrated skeletal muscle fibers are staining with desmin) and CD34 (b) (vessel endothelial cells are staining with CD34)
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case_images: PMC6090953_01_12907_2018_73_Fig6_HTML.jpg
case_images: Fig6
case_images: The lesion was immunonegative for desmin and CD34 (Fig. 6).