case_images: PMC11763788_01
case_images: Ultrasound of spiradenoma. (A) Sagittal view of the tumor. Dotted line represented tumor diameter 2.37 x 0.94 cm. (B) Coronal view of the tumor. Dotted line represented tumor diameter 1.67 cm. (C) Doppler flow study of the tumor.
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case_images: Ultrasound demonstrated a hypoechoic, heterogeneous lesion with well-defined borders, measuring 2.37 x 0.94 x 1.67 cm, without evidence of hypervascularity (Figure 1).
case_images: Gross appearance of the specimen.
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case_images: The tumor was excised intact with a 1 cm safe margin (Figure 2).
case_images: Histopathology of spiradenoma. (A) Pathology shows a well-demarcated encapsulated neoplasm with a multinodular pattern in the dermis and subcutis (H&E stain, 12.5x). Scale bar = 1600 mum. (B) The neoplasm comprises outer peripheral dark small basaloid cells and inner luminal light cells arranged in a trabecular pattern (H&E stain, 200x). (C) Cohesive fashion (H&E stain, 200x) with focal ductal differentiation (arrow). (D) Interconnected strands (H&E stain, 200x) and intercellular mucinous substance (asterisk). Scale bar in (B,C) = 100 mum.
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case_images: It comprised outer basaloid cells displaying a basal cell or myoepithelial phenotype and inner luminal cells arranged in solid, trabecular, and tubular patterns, with areas of focal chondromyxoid stroma (Figure 3).
case_images: Immunohistochemical staining reveals that the inner luminal cells are positive for CK7 (A), while the outer basaloid cells show positivity for p63 (B). Focal positivity is observed for CD56 and CD117 ((C) and (D), respectively). PAX8 staining is negative (E). The Ki67 proliferation index is approximately 10-20% (F). Scale bar = 100 mum.
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case_images: The Ki67 proliferation index ranged from approximately 10% to 20% (Figure 4).