case_images: PMC11758862_01
case_images: Multiple erythematous papules with central necrotic crusts on the trunk (A and B) and extremities (C).
case_images: CCID-18-177-g0001.jpg
case_images: PMC11758862_01_CCID-18-177-g0001.jpg
case_images: f0001
case_images: A 17-year-old female presented with generalized papulonecrotic eruptions on her trunk and extremities for 3 weeks (Figure 1A - C).
case_images: Dense superficial and deep perivascular cell infiltration with epidermal necrosis (H&E; original magnification x40) (A). Atypical small to medium sized lymphoid cells with mitotic activity admixed with some neutrophils and extravasated erythrocytes (H&E; original magnification x400) (B). Atypical cells infiltrated into vascular lumen (H&E; original magnification x400) (C). Angiodestruction of blood vessel (H&E, x400) (D).
case_images: CCID-18-177-g0002.jpg
case_images: PMC11758862_01_CCID-18-177-g0002.jpg
case_images: f0002
case_images: The infiltrating cells were composed mainly of atypical small-to-medium-sized lymphocytes with mitotic activity admixed with some neutrophils and extravasated erythrocytes (Figure 2A and B). The angioinvasion, with atypical cells infiltrated into the lumen of the vessels, and the angiodestruction, represented by fibrinoid necrosis, nuclear dusts, and intraluminal thrombi, were noted (Figure 2C and D).
case_images: The atypical small-to-medium lymphoid cells infiltrating the vessels are positive for CD3 (A), CD8 (B), CD30 (C), CD56 (D), TCR-gamma (E), and 80% positive for Ki-67 (F) (original magnification x400).
case_images: CCID-18-177-g0003.jpg
case_images: PMC11758862_01_CCID-18-177-g0003.jpg
case_images: f0003
case_images: The TCR-gamma was positive, while the beta-F1 (betaF1) was negative. The immunohistochemistry pictures are depicted in Figure 3A - F. The CD30 was positive at 40% of CD3-positive-cells showed in Figure 4A and B.
case_images: CD3-positive cells (A) compared to CD30-positive cells (40%) (B) (original magnification x40).
case_images: CCID-18-177-g0004.jpg
case_images: PMC11758862_01_CCID-18-177-g0004.jpg
case_images: f0004
case_images: The TCR-gamma was positive, while the beta-F1 (betaF1) was negative. The immunohistochemistry pictures are depicted in Figure 3A - F. The CD30 was positive at 40% of CD3-positive-cells showed in Figure 4A and B.