case_images: PMC4281442_01
case_images: Contrast enhanced axial T2 weighted image showing enlarged right lacrimal gland (blue arrow) with soft tissue compromise suggestive of chronic inflammation.
case_images: CRIHEM2014-713048.001.jpg
case_images: PMC4281442_01_CRIHEM2014-713048.001.jpg
case_images: fig1
case_images: An orbital MRI was ordered to study the ophthalmological symptoms (Figure 1), which showed changes suggestive of a chronic, granulomatous inflammation in the right lacrimal gland.
case_images: Orbit (a) histological appearance with diffuse lymphoid infiltrate H&E stain 10x and (b) immunohistochemistry study showing uniform B-cell population CD20, 40x.
case_images: CRIHEM2014-713048.002.jpg
case_images: PMC4281442_01_CRIHEM2014-713048.002.jpg
case_images: fig2
case_images: Histopathological studies (Figures 2 and 3) revealed a predominantly B, lymphoid, and small-cell infiltrate. A renal biopsy showed segmental necrotizing glomerulonephritis (Figure 2) with 60% and 21% cellular and fibrous extracapillary proliferation, respectively, compatible with type 3 extracapillary proliferative glomerulonephritis (type 3, pauci-immune).
case_images: Glomerulus with extracapillary proliferation. Left side with PAS stain, 20x, and to the right with methenamine-silver stain, 20x.
case_images: CRIHEM2014-713048.003.jpg
case_images: PMC4281442_01_CRIHEM2014-713048.003.jpg
case_images: fig3
case_images: Histopathological studies (Figures 2 and 3) revealed a predominantly B, lymphoid, and small-cell infiltrate.