case_images: PMC11767864_01
case_images: Representative micrographs of the tumor; tumor exhibits a combination of architectural patterns (A), notably glandular, tubular cordonal (B), and spindled/solid (C); certain glands and tubules contained eosinophilic colloid-like material (+); tumor cells are medium-to-large in size, possessing eosinophilic cytoplasm and vesicular, anisokaryotic nuclei, sometimes highly atypical with nuclear overlap, prominent nucleoli, and increased mitotic activity (D); (hematoxylin-eosin; A, C: x 100, B: x 200, D: x 400).
case_images: rjaf025f1.jpg
case_images: PMC11767864_01_rjaf025f1.jpg
case_images: f1
case_images: Contacted for a second reading, our pathological anatomy laboratory at the institute concluded on tumor proliferation with a mixture of architectural patterns, notably glandular, tubular cordonal, and spindled/solid (Fig. 1A-C). Certain glands and tubules contained eosinophilic colloid-like material (Fig. 1A). Tumor cells were medium-to-large in size, with eosinophilic cytoplasm and vesicular, anisokaryotic nuclei, sometimes highly atypical with nuclear overlap, prominent nucleoli, and increased mitotic activity (Fig. 1D).
case_images: Immunohistochemical profile of the tumor; tumor cells are positive for TTF1 (A) and negative for GATA3 (B); (A, B: x 200).
case_images: rjaf025f2.jpg
case_images: PMC11767864_01_rjaf025f2.jpg
case_images: f2
case_images: TTF1 and negative for GATA3 (Fig. 2A and B). Thus, the morphological appearance and immunohistochemical profile were compatible with an ovarian MLA.