case_images: PMC8155605_01
case_images: Hematoxylin and Eosin staining of penile metastatic lesions showed poorly differentiated prostatic adenocarcinoma (A: case 1; B: case 2; C: case 3). Two micrographs illustrate (D) PSA+, (E) NKX3.1+ tumor cells of the penile metastatic lesion in case 3.
case_images: fonc-11-683343-g001.jpg
case_images: PMC8155605_03_fonc-11-683343-g001.jpg
case_images: f1
case_images: Ultrasound-guided core needle biopsy was performed, and the histopathology results showed poorly differentiated prostatic adenocarcinoma (Gleason score: 5 + 5 = 10) ( Figure 1C ). An immunostaining panel revealed that the tumor cells were positive for PSA ( Figure 1D ) and NKX3.1 ( Figure 1E ).
case_images: A timeline with relevant data of the 3 cases.
case_images: fonc-11-683343-g003.jpg
case_images: PMC8155605_03_fonc-11-683343-g003.jpg
case_images: f3
case_images: A timeline with relevant data of Case 3 was shown in  Figure 3 .
case_images: PMC8155605_02
case_images: Hematoxylin and Eosin staining of penile metastatic lesions showed poorly differentiated prostatic adenocarcinoma (A: case 1; B: case 2; C: case 3). Two micrographs illustrate (D) PSA+, (E) NKX3.1+ tumor cells of the penile metastatic lesion in case 3.
case_images: fonc-11-683343-g001.jpg
case_images: PMC8155605_03_fonc-11-683343-g001.jpg
case_images: f1
case_images: Ultrasound-guided core needle biopsy was performed, and the histopathology results showed poorly differentiated prostatic adenocarcinoma (Gleason score: 5 + 5 = 10) ( Figure 1C ). An immunostaining panel revealed that the tumor cells were positive for PSA ( Figure 1D ) and NKX3.1 ( Figure 1E ).
case_images: A timeline with relevant data of the 3 cases.
case_images: fonc-11-683343-g003.jpg
case_images: PMC8155605_03_fonc-11-683343-g003.jpg
case_images: f3
case_images: A timeline with relevant data of Case 3 was shown in  Figure 3 .
case_images: PMC8155605_03
case_images: Hematoxylin and Eosin staining of penile metastatic lesions showed poorly differentiated prostatic adenocarcinoma (A: case 1; B: case 2; C: case 3). Two micrographs illustrate (D) PSA+, (E) NKX3.1+ tumor cells of the penile metastatic lesion in case 3.
case_images: fonc-11-683343-g001.jpg
case_images: PMC8155605_03_fonc-11-683343-g001.jpg
case_images: f1
case_images: Ultrasound-guided core needle biopsy was performed, and the histopathology results showed poorly differentiated prostatic adenocarcinoma (Gleason score: 5 + 5 = 10) ( Figure 1C ). An immunostaining panel revealed that the tumor cells were positive for PSA ( Figure 1D ) and NKX3.1 ( Figure 1E ).
case_images: 18F prostate-specific membrane antigen PET/CT showed suspicious tracer uptake in the base of the penis and multiple bone metastases.
case_images: fonc-11-683343-g002.jpg
case_images: PMC8155605_03_fonc-11-683343-g002.jpg
case_images: f2
case_images: The patient remained asymptomatic until March 2020, and serum PSA was found to be 2.4 ng/ml. 18F-prostate specific membrane antigen (18F-PSMA) PET/CT was performed and revealed suspicious tracer uptake in the base of the penis as well as multiple bone metastases ( Figure 2 ).
case_images: A timeline with relevant data of the 3 cases.
case_images: fonc-11-683343-g003.jpg
case_images: PMC8155605_03_fonc-11-683343-g003.jpg
case_images: f3
case_images: A timeline with relevant data of Case 3 was shown in  Figure 3 .