case_images: PMC3687165_01
case_images: Ulcerated lesion along the left lateral border of the tongue
case_images: JOMFP-17-113-g001.jpg
case_images: PMC3687165_01_JOMFP-17-113-g001.jpg
case_images: F1
case_images: Clinical examination showed an ulcerated lesion of 6 x 6 cm, present along the left lateral border of the tongue extending from the base to the tip [Figure 1].
case_images: Sheets and nests of tumor cells involving the dermoepidermal junction (H and E, x40)
case_images: JOMFP-17-113-g002.jpg
case_images: PMC3687165_01_JOMFP-17-113-g002.jpg
case_images: F2
case_images: On microscopy, tumor cells were seen involving the dermoepidermal junction and composed of sheets and nests of cells separated by scant fibrous stroma [Figure 2].
case_images: (a) Spindle shaped tumor cells (b) Epitheloid tumor cells with prominent nucleoli and tumor giant cells (H and E, x400)
case_images: JOMFP-17-113-g003.jpg
case_images: PMC3687165_01_JOMFP-17-113-g003.jpg
case_images: F3
case_images: In focal areas, the cells were spindle shaped and also epitheloid [Figure 3].
case_images: Immunostain for HMB-45 showing strong positivity (IHC, x100)
case_images: JOMFP-17-113-g004.jpg
case_images: PMC3687165_01_JOMFP-17-113-g004.jpg
case_images: F4
case_images: However, the tumor cells showed strong diffuse positivity for Human Melanoma Black 45 (HMB) [Figure 4] confirming the diagnosis of malignant (amelanotic) melanoma of the tongue with metastases to the left cervical lymph node.