case_images: PMC6105593_01
case_images: a Pedigree and b audiometric configurations of the proband (P). Closed symbols indicate affected individuals. The high frequency hearing thresholds of this patient progressed over the follow-up period and eventually showed flat-type moderate hearing loss
case_images: 41439_2018_23_Fig1_HTML.jpg
case_images: PMC6105593_01_41439_2018_23_Fig1_HTML.jpg
case_images: Fig1
case_images: His maternal grandmother, mother, maternal uncle, and sister also have late-onset hearing loss (after acquisition of language) (Fig. 1a). The hearing loss was progressive, and an audiogram at age 43 showed hearing loss at all frequencies with a flat pattern (Fig. 1b).
case_images: Results of the proband's a electrocardiogram and b echocardiograph. The electrocardiogram revealed a minor abnormality in the Q wave at V1 and V2, while the echocardiography revealed mild mitral valve regurgitation from the left ventricle to the left atrium
case_images: 41439_2018_23_Fig2_HTML.jpg
case_images: PMC6105593_01_41439_2018_23_Fig2_HTML.jpg
case_images: Fig2
case_images: His electrocardiogram revealed an abnormal Q wave at V1 and V2 (Fig. 2a); however, the cardiologist evaluated it to be within the normal range. Echocardiography revealed mild mitral valve regurgitation from the left ventricle to the left atrium (Fig. 2b), but this was judged not to affect cardiac function.