case_images: PMC8566709_01
case_images: Clinical picture of the patient. Elevated, keloid-like, fine nodules coalescing into diffuse sclerodermoid plaques in a background of erythema were found on the right upper arm, chest wall, and abdomen.
case_images: fonc-11-747123-g001.jpg
case_images: PMC8566709_01_fonc-11-747123-g001.jpg
case_images: f1
case_images: On examination, the chest wall and abdomen were diffusely indurated with erythematous nodules coalescing into diffuse sclerodermoid plaques in a background of erythema, and the right upper arm was also involved (Figure 1).
case_images: Skin histopathology of the patient. (A, B) Biopsy specimen of the chest showed single files or small clusters of monomorphous atypical cells with a cytoplasm rich in vacuoles seen in the dermis [(A) hematoxylin and eosin, x50; (B) hematoxylin and eosin, x100]. (C, D) Immumohistochemical staining showed the tumor cells were CK7+ (C) and ER+ (D) (x200).
case_images: fonc-11-747123-g002.jpg
case_images: PMC8566709_01_fonc-11-747123-g002.jpg
case_images: f2
case_images: A biopsy of chest lesion showed a proliferation of monomorphous atypical tumor cells with a cytoplasm rich in vacuoles, presenting a single-file pattern or in small clusters (Figures 2A, B). Immunohistochemical staining revealed atypical cells were positive for cytokeratin 7 and estrogen receptor, but cytokeratin 20, progesterone receptor, and GCDFP-15 were negative (Figures 2C, D).