case_images: PMC3568418_01
case_images: A, Photograph showing the clinical appearance of the lesion. B, Lesion afterincisional biopsy.
case_images: 1756-0500-6-30-1.jpg
case_images: PMC3568418_01_1756-0500-6-30-1.jpg
case_images: F1
case_images: Clinically, the lesions appeared as spots with imprecise borders, had a brown to dark brown color, and presented a tendency towards nodule formation (Figure 1).
case_images: Histopathological appearance of melanoacanthoma stained with hematoxylin-eosin at different magnifications (A: 100x; B: 200x; C: 400x) and stained with periodic acid Schiff at 200x magnification (D).
case_images: 1756-0500-6-30-2.jpg
case_images: PMC3568418_01_1756-0500-6-30-2.jpg
case_images: F2
case_images: In view of the histopathological findings, a diagnosis of MA was made (Figure 2).
case_images: Immunostainingfor melan-A at three different magnifications.
case_images: 1756-0500-6-30-3.jpg
case_images: PMC3568418_01_1756-0500-6-30-3.jpg
case_images: F3
case_images: Anti-Ki-67, anti-MCM-2 and anti-geminin antibodies only reacted with cells of the basal and suprabasal layers of the epithelium, whereas MCM-5 staining was negative (Figures 3 and 4).
case_images: Immunostaining for geminin (A), Ki-67 (B), MCM-2 (C), and MCM-5 (D).
case_images: 1756-0500-6-30-4.jpg
case_images: PMC3568418_01_1756-0500-6-30-4.jpg
case_images: F4
case_images: Anti-Ki-67, anti-MCM-2 and anti-geminin antibodies only reacted with cells of the basal and suprabasal layers of the epithelium, whereas MCM-5 staining was negative (Figures 3 and 4).