case_images: PMC11816982_01
case_images: Onset manifestations of generalized pustular psoriasis. Few erythematous patches surmounted by pustules on the trunk and lower limbs (A). Severe and diffuse sub-erythrodermic state with residual pustules and desquamation after 2 weeks from onset with coexist (B-D)
case_images: 13052_2024_1835_Fig1_HTML.jpg
case_images: PMC11816982_01_13052_2024_1835_Fig1_HTML.jpg
case_images: Fig1
case_images: A 7-years-old girl, with history of plaque-psoriasis since the age of 6 months and no comorbidities, presented to our attention for the sudden appearance of erythematous patches surmounted by pustules on her trunk and lower limbs, following repeated episodes of purulent tonsillitis (Fig. 1A). Cyclosporine was started at a dosage of 3.5 mg/kg/day (body weight: 30 kg), with no clinical benefit and progression to a severe sub-erythrodermic state after 2 weeks (GPPASI 25, GPPGA 4) (Fig. 1B-D).
case_images: Complete resolution of skin manifestations. Clinical (GPPASI 0, GPPGA 0, NRS pruritus 0, cDLQI 0) and symptomatological remission at week-8 of treatment with ixekizumab
case_images: 13052_2024_1835_Fig2_HTML.jpg
case_images: PMC11816982_01_13052_2024_1835_Fig2_HTML.jpg
case_images: Fig2
case_images: At week-8 the patient achieved complete remission of skin manifestations (GPPASI 0, GPPGA 0, NRS pruritus 0, cDLQI 0) and normalization of blood count (Fig. 2).