case_images: PMC11020740_01
case_images: Clinical course of retinal venous occlusion.. Serial imaging of cases 1-4 documenting rapid resolution of edema, hemorrhage, and venous stasis. Cases 1 and 4: Serial fundus photographs show resolution of venous stasis and hemorrhage. OCT's document resolution of RNFL swelling. Cases 2 and 3: Fundus photographs show resolution of venous stasis and hemorrhage. OCT's documents rapid resolution of significant macular edema.. RNFL, retinal nerve fiber layer.
case_images: 10.1177_25158414241240687-fig1.jpg
case_images: PMC11020740_01_10.1177_25158414241240687-fig1.jpg
case_images: fig1-25158414241240687
case_images: Figure 1 shows a photomontage of fundus photography and OCT at the time of diagnosis juxtaposed with imaging at the time of clinical resolution in four of the five subjects (OCT was unavailable for the fifth case).
case_images: The orange curve in the figure represents the aggregate ARNFL as a percentage return to normative data* for all subjects over the course of treatment. The corresponding light orange line is the linear regression of this curve. The black curve in Figure 2 represents the reduction in the aggregate ARNFL for all subjects as a percentage thickness from the time of diagnosis over the course of treatment. The corresponding blue line is the linear regression of this curve.. Source: Normative data was taken from the Zeiss 510k summary.
  
  . ARNEL, average retinal nerve fiber layer.
case_images: 10.1177_25158414241240687-fig2.jpg
case_images: PMC11020740_01_10.1177_25158414241240687-fig2.jpg
case_images: fig2-25158414241240687
case_images: The retinal recovery index (RRI) was plotted as shown in Figures 2 and 3 by calculating the percent change toward normal values for average retinal nerve fiber layer (ARNFL) and central macular thickness (CMT) by 3-month intervals.
case_images: The orange curve in the figure represents the aggregate CMT as a percentage return to normative data* for all subjects over the course of treatment. The corresponding light orange line is the linear regression of this curve. The black curve in Figure 3 represents the reduction in the aggregate CMT for all subjects as a percentage thickness from the time of diagnosis over the course of treatment. The corresponding blue line is the linear regression of this curve.. Source: Normative data was taken from the Zeiss 510k summary.
  
  . CMT, central macular thickness.
case_images: 10.1177_25158414241240687-fig3.jpg
case_images: PMC11020740_01_10.1177_25158414241240687-fig3.jpg
case_images: fig3-25158414241240687
case_images: The retinal recovery index (RRI) was plotted as shown in Figures 2 and 3 by calculating the percent change toward normal values for average retinal nerve fiber layer (ARNFL) and central macular thickness (CMT) by 3-month intervals.
case_images: Figures (a) and (b) report the average ARNFL and CMT for the observed eyes as a percent of the normative levels. Values are reported in 4-month intervals, where, for 4, 8, and 12 months, any value recorded within the interval is included in the average value reported at the end of the interval. The values for 0 months are set as the average of the baseline ARNFL and CMT values, respectively, and the values for 16 months reflect observations post-16 months. If a given eye appeared more than once in a given interval, then the observed values of that eye were averaged within the interval in question. Thus, all eyes included in calculating the average for a given interval are weighted equally. If an eye did not have an observation within a given interval, then that eye was not included in calculating the average ARNFL value for that interval. Thus, each interval does not necessarily include the same eyes in calculating its average ARNFL. Two lines of best fit are included for the intervals from 0 to 8 and 8 to 16+ months. The lines are reported separately to demonstrate the steeper initial decline in the ARNFL value, followed by a more gradual decline, representing biphasic edema resolution. The slope of the first and second ARNFL lines reflect a 6.2 and 2.5 percentage points decline per month, respectively. The slope of the first and second CMT lines reflect a 2.165 and 0.988 percentage point decline per month, respectively. In each case, the figures reveal a steep initial decline in ARNFL and CMT, followed by a more gradual resolution of edema over time.
case_images: 10.1177_25158414241240687-fig4.jpg
case_images: PMC11020740_01_10.1177_25158414241240687-fig4.jpg
case_images: fig4-25158414241240687
case_images: Figure 4(a) and (b) were made to show the slope of recovery over the first 0-8 months of treatment and the subsequent 8-16 months of treatment, with the outcome variables of interest being ARNFL as a percent of normative ARNFL data and CMT as a percentage of normative CMT data, respectively.
case_images: PMC11020740_02