case_images: PMC6249337_01
case_images: Pedigree of the family. The arrow indicates the proband. Circles indicate females, squares indicate males. The diagonal line indicates a deceased family member. Black squares/circles indicate a carrier of the FHM3 (c.4495T>C) mutation with hemiplegic migraine. White squares/circles indicate subjects that are neither patients nor mutation carriers.
case_images: fneur-09-00976-g0001.jpg
case_images: PMC6249337_03_fneur-09-00976-g0001.jpg
case_images: F1
case_images: The proband's nephew (Figure 1, III-1), a 25-year-old fitness coach, had first headache attacks with visual symptoms (scotomata) and lateralized motor weakness at the age of 13.
case_images: MRA and MRI images of the female patient show no meaningful abnormalities.
case_images: fneur-09-00976-g0002.jpg
case_images: PMC6249337_03_fneur-09-00976-g0002.jpg
case_images: F2
case_images: After admission, her neurological examinations were unremarkable and brain magnetic resonance imaging (MRI) and Magnetic Resonance Angiography (MRA) showed no meaningful abnormalities (Figure 2).
case_images: The next-generation sequencing results of exon 26 of the gene SCN1A in members of this family. (A) Proband with the T   C mutation, (B) the proband's unaffected son without the T   C mutation, (C) the proband's brother with the T   C mutation, (D) the proband's unaffected granddaughter without the T   C mutation.
case_images: fneur-09-00976-g0003.jpg
case_images: PMC6249337_03_fneur-09-00976-g0003.jpg
case_images: F3
case_images: We only found a gene mutation in SCN1A, but this mutation was detected in all affected subjects in this family (Figure 3).
case_images: PMC6249337_02
case_images: Pedigree of the family. The arrow indicates the proband. Circles indicate females, squares indicate males. The diagonal line indicates a deceased family member. Black squares/circles indicate a carrier of the FHM3 (c.4495T>C) mutation with hemiplegic migraine. White squares/circles indicate subjects that are neither patients nor mutation carriers.
case_images: fneur-09-00976-g0001.jpg
case_images: PMC6249337_03_fneur-09-00976-g0001.jpg
case_images: F1
case_images: The proband's nephew (Figure 1, III-1), a 25-year-old fitness coach, had first headache attacks with visual symptoms (scotomata) and lateralized motor weakness at the age of 13.
case_images: PMC6249337_03
case_images: Pedigree of the family. The arrow indicates the proband. Circles indicate females, squares indicate males. The diagonal line indicates a deceased family member. Black squares/circles indicate a carrier of the FHM3 (c.4495T>C) mutation with hemiplegic migraine. White squares/circles indicate subjects that are neither patients nor mutation carriers.
case_images: fneur-09-00976-g0001.jpg
case_images: PMC6249337_03_fneur-09-00976-g0001.jpg
case_images: F1
case_images: The proband's nephew (Figure 1, III-1), a 25-year-old fitness coach, had first headache attacks with visual symptoms (scotomata) and lateralized motor weakness at the age of 13.
case_images: MRA and MRI images of the female patient show no meaningful abnormalities.
case_images: fneur-09-00976-g0002.jpg
case_images: PMC6249337_03_fneur-09-00976-g0002.jpg
case_images: F2
case_images: After admission, her neurological examinations were unremarkable and brain magnetic resonance imaging (MRI) and Magnetic Resonance Angiography (MRA) showed no meaningful abnormalities (Figure 2).
case_images: The next-generation sequencing results of exon 26 of the gene SCN1A in members of this family. (A) Proband with the T   C mutation, (B) the proband's unaffected son without the T   C mutation, (C) the proband's brother with the T   C mutation, (D) the proband's unaffected granddaughter without the T   C mutation.
case_images: fneur-09-00976-g0003.jpg
case_images: PMC6249337_03_fneur-09-00976-g0003.jpg
case_images: F3
case_images: We only found a gene mutation in SCN1A, but this mutation was detected in all affected subjects in this family (Figure 3).