case_images: PMC5336392_01
case_images: Bone marrow biopsy (H & E), 20% cellularity (magnification x 100).
case_images: can-11-720fig1.jpg
case_images: PMC5336392_01_can-11-720fig1.jpg
case_images: figure1
case_images: Staining for PNCA was less than 1% and there was no evidence of fibrosis or lymphoid follicular formation (Figure 1).
case_images: Low power biopsy ganglia (x 10).
case_images: can-11-720fig2.jpg
case_images: PMC5336392_01_can-11-720fig2.jpg
case_images: figure2
case_images: There was 70% of the lymph node parenchyma being replaced with an infiltration of morphologically mature plasma cells as well as loss of the normal architecture (Figure 2, 3).
case_images: Infiltration by plasma cells (x 400).
case_images: can-11-720fig3.jpg
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case_images: figure3
case_images: There was 70% of the lymph node parenchyma being replaced with an infiltration of morphologically mature plasma cells as well as loss of the normal architecture (Figure 2, 3).
case_images: Plasma cells CD38 (+) (x 10).
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case_images: figure4
case_images: Plasma cells CD19 (+) (x 10).
case_images: can-11-720fig5.jpg
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case_images: figure5
case_images: Kappa expression (x 400).
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case_images: figure6
case_images: Lambda expression (x 600).
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case_images: figure7
case_images: Bone marrow biopsy showing hypercellular features and infiltration by plasma cells (x 400).
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case_images: figure8
case_images: The bone marrow biopsy (Figure 8) showed a variable cellularity occupying between 10-90% of the intertrabecular spaces with over 70% being plasma cells, diffusely infiltrated between a few myeloid precursors.
case_images: Bone marrow biopsy stained for kappa (x 400).
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case_images: figure9
case_images: Immunocytochemistry showed a lambda:kappa ratio of 9:1 (Figure 9, 10), the plasma cells being negative for CD20 and positive for CD19, CD38, and CD138, and 20% of plasma cells being positive for Bcl-2.
case_images: Bone marrow stained for lambda (x 1000).
case_images: can-11-720fig10.jpg
case_images: PMC5336392_01_can-11-720fig10.jpg
case_images: figure10
case_images: Immunocytochemistry showed a lambda:kappa ratio of 9:1 (Figure 9, 10), the plasma cells being negative for CD20 and positive for CD19, CD38, and CD138, and 20% of plasma cells being positive for Bcl-2.
case_images: Flow cytometry of bone marrow showing CD56 (-) CD19 (+) phenotype.
case_images: can-11-720fig11.jpg
case_images: PMC5336392_01_can-11-720fig11.jpg
case_images: figure11
case_images: The cells were CD56, CD117, CD20, CD22, and HLA-DR negative (Figure 11).