case_images: PMC11757135_01
case_images: Lymph node biopsy pathology. (A) HE (low-power lens), (B) HE (high-power lens). Lymph node staining revealed features consistent with histiocytic necrotizing lymphadenitis. There was hyperplasia of the paracortical region, with prominent karyorrhexis in necrotic areas. Peripheral cells were larger, with pale-staining nuclei, and some cells displayed crescent-shaped nuclei (yellow arrows) and nuclear division (green arrows).
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case_images: f1
case_images: Lymph node biopsy demonstrated hyperplasia of the paracortical area, predominantly of cytotoxic T cells, with numerous irregular and crescent-shaped histiocytes and proliferating plasmacytoid dendritic cells, along with extensive nuclear debris and areas of patchy necrosis, which are hallmark features of KFD ( Figure 1 ).
case_images: Immunohistochemical findings of cervical lymph nodes. (A) CD3+ staining demonstrates abundant T cells in the lymph node paracortex; (B) CD8+ staining highlights the predominance of cytotoxic T cells; (C) CD68+ staining reveals an abundance of histiocytes; and (D) CD123+ staining indicates the presence of plasmacytoid dendritic cells.
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case_images: f2
case_images: Additionally, Ki-67 positivity (~70%) and CD68 positivity were observed, while molecular pathology demonstrated EBER-ISH negativity ( Figure 2 ).
case_images: Daily maximum temperature variations during hospitalization.
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case_images: PMC11757135_01_fimmu-15-1519988-g003.jpg
case_images: f3
case_images: The patient's general condition improved after steroid therapy, and his fever resolved on the second day of treatment ( Figure 3 ).