case_images: PMC3629270_01
case_images: Photograph showing the ~6x5-cm superficial mass in the posterolateral aspect of the left proximal thigh.
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case_images: Physical examination revealed a ~6x5-cm superficial, firm, non-tender mass in the posterolateral aspect of the left proximal thigh (Fig. 1).
case_images: (A) Plain radiograph reveals a soft tissue mass with amorphous calcification and extensive foci of ossification. (B) Three-dimensional computed tomography image shows the presence of the lesion and the normal appearance of the proximal femur. (C) Technetium-99m hydroxymethylenediphosphonate bone scintigraphy reveals heterogenous uptake in the lateral soft tissue of the left proximal thigh.
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case_images: Plain radiographs showed a soft tissue mass with amorphous calcification and extensive foci of ossification (Fig. 2A). Computed tomography (CT) images demonstrated and confirmed an incompletely ossified shell in the lesion (Fig. 2B). Technetium-99m hydroxymethylenediphosphonate bone scintigraphy demonstrated heterogenous uptake in the lateral soft tissue of the left proximal thigh (Fig. 2C).
case_images: Axial magnetic resonance images of ossifying fibromyxoid tumor in the left proximal thigh. (A) The T1-weighted sequence shows that the mass has low to intermediate signal intensity. (B) The T2-weighted spectral presaturation with inversion recovery sequence shows that the mass has heterogeneous high signal intensity with foci of low signal intensity. (C) The contrast-enhanced T1-weighted sequence shows heterogenous enhancement throughout the mass.
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case_images: The mass exhibited low to intermediate signal intensity on T1-weighted sequences (Fig. 3A) and heterogeneous high signal intensity, with foci of low signal intensity, on T2-weighted spectral presaturation with inversion recovery sequences (Fig. 3B). Contrast-enhanced T1-weighted sequences demonstrated heterogenous enhancement throughout the mass (Fig. 3C).
case_images: Cut section of the ossifying fibromyxoid tumor displaying a well-circumscribed, gray-white, multinodular appearance.
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case_images: A cut section revealed that the tumor was gray-white, solid, multinodular and rubbery to firm in consistency (Fig. 4).
case_images: Histopathological and immunohistochemical findings of ossifying fibromyxoid tumor. (A) The tumor is composed of relatively uniform round to oval cells with eosinophilic cytoplasm. (B) A peripheral shell of mature lamellar bone is evident. The tumor cells are immunoreactive for (C) S-100 protein and (D) neuron-specific enolase.
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case_images: Histopathologically, the tumor was composed of uniform oval, polygonal or spindle-shaped cells, accompanied by an abundant fibromyxoid stroma (Fig. 5A). Ossification-forming bone shells were found in the periphery of the tumor (Fig. 5B). Immunohistochemically, the tumor cells were positive for vimentin, S-100 protein (Fig. 5C) and neuron-specific enolase (Fig. 5D), and focally for smooth muscle actin and CD56.