case_images: PMC3504292_01
case_images: Ulcerative plaque on the dorsal foot, the blue elliptical line indicates the site of the biopsy (a), multiple ulcerative nodules behind the lateral malleolus (b), microscopic view of septal and lobular panniculitis H&E stain x100 (c).
case_images: CRIM.DM2012-612434.001.jpg
case_images: PMC3504292_01_CRIM.DM2012-612434.001.jpg
case_images: fig1
case_images: Dermatological examination revealed a large ulcerative plaque on the dorsal aspect of the left foot surrounded by two satellite purple papules (Figure 1(a)). In addition to multiple grouped dusky erythematous nontender ulcerative nodules behind the lateral malleolus of the left leg (Figure 1(b)). These changes even involved the panniculus causing septal and lobular panniculitis (Figure 1(c)).
case_images: PMC3504292_02
case_images: Microscopic view of septal and lobular panniculitis H&E x400 (a), dermal foci of intra and extracellular LT bodies H&E x1000 (b), non-metachromatic LT bodies Gimesa stain x1000 (c).
case_images: CRIM.DM2012-612434.002.jpg
case_images: PMC3504292_02_CRIM.DM2012-612434.002.jpg
case_images: fig2
case_images: The fatty lobules and its septa were infiltrated by lymphocytes, histiocytes, and plasma cells causing both septal and lobular panniculitis (Figure 2(a)). Aggregations of high number of LT bodies were seen mainly inside of macrophages of the superficial dermis stained by H&E (Figure 2(b)). Gimesa stain confirmed the presence of the non-metachromatic nuclei of the LT bodies (Figure 2(c)).