case_images: PMC10961011_01
case_images: Regression of piebaldism-related depigmented body patches during the growth period of the patient. (A) At 3 months old, the patient presented with a distinct triangularly shaped depigmentation pattern of forehead and white forelock (WF) of hair (left), large depigmented patches in the abdomen with some patches and macules with normal pigmentation (middle), and a large depigmented patch on the right lower limb with some normal pigmented macules and patches (right). (B) At 8 months of age, the WF manifestation remained unchanged, indicating pigmentation absence (left); the abdominal skin features also remained unchanged, indicative of pigmentation absence (middle); however, the lower limbs started to show signs of pigmentation with the development of new hyperpigmented macules (black arrows, right). (C) At the age of 7 years, the skin of the WF showed signs of pigmentation (especially at the periphery of the lesion) but the hair remained white in color; furthermore, additional cafe-au-lait macules appeared as hyperpigmented patches (left), the abdominal skin area showed massive pigmentation in the depigmented patch (middle), and pigmentation on both lower limbs was noticeable (right).
case_images: CCID-17-713-g0001.jpg
case_images: PMC10961011_02_CCID-17-713-g0001.jpg
case_images: f0001
case_images: The patient was examined again at the age of 8 months, showing the same clinical presentation as before but with new pigmented macules appearing in the lower limbs (Figure 1B), and later on at the age of 7 years, showing newly extensive pigmentation of the upper and lower limbs, and abdomen skin, as well as in the periphery of the WF (Figure 1C). In addition, the patient developed multiple CALMs in the upper eyelids of the right eye and right upper arm (Figure 1C).
case_images: PMC10961011_02
case_images: Regression of piebaldism-related depigmented body patches during the growth period of the patient. (A) At 3 months old, the patient presented with a distinct triangularly shaped depigmentation pattern of forehead and white forelock (WF) of hair (left), large depigmented patches in the abdomen with some patches and macules with normal pigmentation (middle), and a large depigmented patch on the right lower limb with some normal pigmented macules and patches (right). (B) At 8 months of age, the WF manifestation remained unchanged, indicating pigmentation absence (left); the abdominal skin features also remained unchanged, indicative of pigmentation absence (middle); however, the lower limbs started to show signs of pigmentation with the development of new hyperpigmented macules (black arrows, right). (C) At the age of 7 years, the skin of the WF showed signs of pigmentation (especially at the periphery of the lesion) but the hair remained white in color; furthermore, additional cafe-au-lait macules appeared as hyperpigmented patches (left), the abdominal skin area showed massive pigmentation in the depigmented patch (middle), and pigmentation on both lower limbs was noticeable (right).
case_images: CCID-17-713-g0001.jpg
case_images: PMC10961011_02_CCID-17-713-g0001.jpg
case_images: f0001
case_images: The patient was examined again at the age of 8 months, showing the same clinical presentation as before but with new pigmented macules appearing in the lower limbs (Figure 1B), and later on at the age of 7 years, showing newly extensive pigmentation of the upper and lower limbs, and abdomen skin, as well as in the periphery of the WF (Figure 1C). In addition, the patient developed multiple CALMs in the upper eyelids of the right eye and right upper arm (Figure 1C).
case_images: PMC10961011_03