case_images: PMC11798477_01
case_images: Treatment timeline with days from diagnosis.. Abbreviations: PR: partial response; SD: stable disease; POD: progression of disease. Terms designated according to the RECIST criteria. Abbreviations: CT: computed tomography; C/A/P: chest, abdomen, pelvis; MRI: magnetic resonance imaging; XRT: radiation therapy.
case_images: oncotarget-16-28682-g001.jpg
case_images: PMC11798477_01_oncotarget-16-28682-g001.jpg
case_images: F1
case_images: A 42-year-old man who had never smoked presented with cough and wheezing (Figure 1, day 0 on the treatment timeline).
case_images: Radiographic response imaging to pralsetinib plus lorlatinib.. (A) Computed tomography (CT) during lorlatinib treatment revealing right cervical lymph node. (B) CT showing decrease in lymph node size with necrosis after addition of pralsetinib. (C) Chest CT during lorlatinib treatment showing right-sided pleural effusion. (D) Chest CT showing decrease in effusion after pralsetinib treatment. Images A and C were taken on day 1135 post-diagnosis. Images B and D were taken on day 1268.
case_images: oncotarget-16-28682-g002.jpg
case_images: PMC11798477_01_oncotarget-16-28682-g002.jpg
case_images: F2
case_images: The patient had no severe adverse events, and a radiographic response was achieved on CT imaging one month later (Figure 2), with significant decrease in the right cervical lymph node, stable supraclavicular nodes, stable CNS and osseous metastases, and decrease in pulmonary disease and pleural effusion.