case_images: PMC10797129_01
case_images: Tumor location and preoperative examinations. (A) MRI reconstruction showing the size and location of the tumor. (B) Neck ultrasound showing abundant blood supply to the tumor. (C) The maximum intensity projection (MIP) images summarizing the pathological distribution of [18F]-FDG in the tumor. (D) PET/CT scan showing heterogeneously intense FDG uptake in tumor.
case_images: fonc-13-1310290-g001.jpg
case_images: PMC10797129_02_fonc-13-1310290-g001.jpg
case_images: f1
case_images: The Ki-67 staining exhibited a positive rate of 5%, while the p53 staining showed a positive rate of 10% ( Supplementary Figure 1 ).
case_images: CT and MRI examinations. (A) Enhanced CT scan of the neck in horizontal position. (B) Enhanced CT scan of the neck in coronary position. (C) Enhanced CT scan of the neck in sagittal position. (D) Enhanced MRI scan of the neck in horizontal position. (E) Enhanced MRI scan of the neck in coronary position. (F) Enhanced MRI scan of the neck in sagittal position.
case_images: fonc-13-1310290-g002.jpg
case_images: PMC10797129_01_fonc-13-1310290-g002.jpg
case_images: f2
case_images: The lower boundary of the tumor extended to the upper mediastinum, and compression caused displacement of the trachea towards the left, as depicted in  Figures 2A-C . Additionally, the T1 and T2 signals of the tumor appear heterogeneous, and there is a notable enhancement observed ( Figures 2D-F ).
case_images: PMC10797129_02
case_images: Tumor location and preoperative examinations. (A) MRI reconstruction showing the size and location of the tumor. (B) Neck ultrasound showing abundant blood supply to the tumor. (C) The maximum intensity projection (MIP) images summarizing the pathological distribution of [18F]-FDG in the tumor. (D) PET/CT scan showing heterogeneously intense FDG uptake in tumor.
case_images: fonc-13-1310290-g001.jpg
case_images: PMC10797129_02_fonc-13-1310290-g001.jpg
case_images: f1
case_images: The Ki-67 staining exhibited a positive rate of 5%, while the p53 staining showed a positive rate of 10% ( Supplementary Figure 1 ).
case_images: Surgery images and histopathological and immunohistochemical examinations. (A) Appearance of the tumor after resection. (B) Image of the surgical cavity after tumor resection. (C) Hematoxylin and eosin stainingx100. (D) PTHx100. (E) Ber-EP4x100. (F) Synx100.
case_images: fonc-13-1310290-g003.jpg
case_images: PMC10797129_02_fonc-13-1310290-g003.jpg
case_images: f3
case_images: Furthermore, it was found to be closely adherent to both the internal jugular vein and the common carotid artery ( Figures 3A, B ). The lesion was determined to be parathyroid carcinoma based on post-operative pathology analysis ( Figure 3C ). The immunohistochemical analysis revealed robust expression of parathyroid hormone (PTH) ( Figure 3D ), as well as notable positivity for Ber-ep4 and syn ( Figures 3E, F ).