case_images: PMC5828308_01
case_images: PMC5828308_02
case_images: (a) Thyroiditis: hyperthyroid phase followed by hypothyroid phase in a patient treated with pembrolizumab. (b) Hyperthyroidism generally occurred within 3-6 weeks of initiation of pembrolizumab therapy (time = 0). Hypothyroid phase was evident by week 9 of pembrolizumab therapy and was characterised by markedly elevated TSH levels.
case_images: JSC2018-9602540.003.jpg
case_images: PMC5828308_02_JSC2018-9602540.003.jpg
case_images: fig3
case_images: Thyroiditis was characterised by a brief asymptomatic hyperthyroid phase followed by a symptomatic hypothyroid phase (Figure 3(a)) requiring thyroxine replacement. In most cases, the hypothyroid phase was evident by week 9 of pembrolizumab therapy and was characterised by markedly elevated TSH levels (Figure 3(b)).
case_images: PMC5828308_03