case_images: PMC3010644_01
case_images: Horizontal (a) and axial (b) enhanced computed tomography (CT) showed an inhomogeneously enhancing mass that filled the left nasal cavity. A low-density lesion with metal-dense spots in the left maxillary sinus, indicating mycetoma, was also observed. Bone window images ((c), (d)) also showed a new bone formation in the tumor. Black arrows indicate a new bone formation.
case_images: IJOL2010-154948.001.jpg
case_images: PMC3010644_01_IJOL2010-154948.001.jpg
case_images: fig1
case_images: The tumor grew expansively and showed marked osteogenesis (Figure 1).
case_images: Horizontal (a) and axial (b) magnetic resonance imaging (MRI) showed a nasal tumor in the left nasal cavity with a hypointense signal on T1-weighted images, and a moderately hyperintense signals on T2-weighted images. This signal was different from that of the left maxillary sinus lesions.
case_images: IJOL2010-154948.002.jpg
case_images: PMC3010644_01_IJOL2010-154948.002.jpg
case_images: fig2
case_images: T1-weighted images, and a moderately hyperintense signals on T2-weighted images (Figure 2). The signal of the nasal tumor was distinctly different from that of the left maxillary sinus lesions.
case_images: Macroscopic (a) and microscopic (x100 magnification) (b) features of the excised tumor. The spindle cells are arranged in a patternless fashion, and new bone formation consisting of randomly organized trabeculae lined by osteoblasts was observed in the tumor. black arrows and *asterisk: bone tissue.
case_images: IJOL2010-154948.003.jpg
case_images: PMC3010644_01_IJOL2010-154948.003.jpg
case_images: fig3
case_images: The tumor was thus successfully removed in one piece with the surgical margin free of disease (Figure 3(a)).  Histopathologically, a patternless proliferation of spindle cells and new bone formation consisting of randomly organized trabeculae lined by osteoblasts were observed in the tumor (Figure 3(b)).
case_images: Immunohistochemistry for bone morphogenic protein (BMP; x100 magnification). (a) BMP-2, (b) BMP-4, and (c) BMP-7. The tumor cells stained positive for BMP-4 and negative for BMP-2 and BMP-7. *asterisk: bone tissue.
case_images: IJOL2010-154948.004.jpg
case_images: PMC3010644_01_IJOL2010-154948.004.jpg
case_images: fig4
case_images: IgG (Vector Laboratories, Burlingame, CA). After rinsing, sections were incubated with ABC reagent (Vector Laboratories) and developed in 0.05% 3,3'-diaminobenzidine-0.01% H2O2 substrate medium in 0.1 M phosphate buffer. Interestingly, the tumor cells stained positive for BMP-4 and negative for BMP-2 and BMP-7 (Figure 4).
case_images: Western blot analysis for BMP. The tumor tissue expressed BMP-4 but not BMP-2 and -7.
case_images: IJOL2010-154948.005.jpg
case_images: PMC3010644_01_IJOL2010-154948.005.jpg
case_images: fig5
case_images: The result showed the expression of BMP-4, but not BMP-2 and -7, in the similar manner to the result of immunohistochemistry (Figure 5). 