case_images: PMC10995286_01
case_images: Percentage of miRNA hits in the original differentially expressed miRNA list and MHIF-MSEA expanded list for breast cancer (A) and hepatocellular carcinoma (B).
case_images: fgene-15-1375148-g003.jpg
case_images: PMC10995286_01_fgene-15-1375148-g003.jpg
case_images: F3
case_images: After expansion by MHIF-MSEA, the expanded miRNA list overlapped with 238 miRNAs from the breast cancer miRNA set, achieving an increased hit rate of 68.78%, representing an improvement of 39.01%, as shown in Figure 3A. As shown in Figure 3B, the hepatocellular carcinoma disease miRNA set contained 338 miRNAs and only 86 miRNAs from the original differentially expressed miRNA list, with a hit rate of 25.44%.
case_images: The top 20 significantly enriched functional entries exported by MHIF-MSEA among hepatocellular carcinoma differentially expressed miRNAs.
case_images: fgene-15-1375148-g004.jpg
case_images: PMC10995286_01_fgene-15-1375148-g004.jpg
case_images: F4
case_images: The results of the significantly enriched pathways, both for the MHIF-MSEA expanded list and the original list, are depicted in Figure 4.
case_images: Significantly enriched functional entries only identified by MHIF-MSEA among hepatocellular carcinoma differentially expressed miRNAs.
case_images: fgene-15-1375148-g005.jpg
case_images: PMC10995286_01_fgene-15-1375148-g005.jpg
case_images: F5
case_images: This can be observed in Figure 5, which highlights the pathways uniquely identified by MHIF-MSEA.