case_images: PMC11285637_01
case_images: Neuropsychological profile at initial presentation and follow-up. (A) shows the neuropsychological profile at the initial presentation, and (B) at the follow-up. A slight improvement in figure construction and the Boston naming test at follow-up can be seen. The red solid line indicates the twofold standard deviation, while the dashed red line means the single standard deviation.
case_images: frdem-02-1227823-g0001.jpg
case_images: PMC11285637_01_frdem-02-1227823-g0001.jpg
case_images: F1
case_images: A detailed neuropsychological examination revealed impaired cognitive flexibility, impaired figural memory, verbal memory impairment in encoding, delayed recall of complex verbal content, and consolidation of verbal non-associated information (Figure 1A). In this 2022 examination (Figure 1B), we noted a worse mental performance in cognitive fluency, switching ability, and immediate memory span compared to the 2020 examination.
case_images: Imaging. (A-D) 18F-FDG-PET. Brain hemisphere surface projections of 18F-FDG- uptake in right lateral (A), left lateral (B), right medial (C), and left medial (B) views show reduced tracer uptake in the temporal cortex, the posterior cingulate, precuneus, and slightly reduced uptake in the visual cortex (white arrows). (E)
  123I-FP-CIT-SPECT in axial view showing abundant tracer uptake in the right putamen and lower uptake in the left putamen (white arrows). 123I-FP-CIT-SPECT, Single photon emission computed tomography with [(123)I]; N-omega-fluoropropyl-2betacarbomethoxy-3beta-{4-iodophenyl}nortropane; 18F-FDG-PET, 18F fluorodesoxyglucose positron emission tomography.
case_images: frdem-02-1227823-g0002.jpg
case_images: PMC11285637_01_frdem-02-1227823-g0002.jpg
case_images: F2
case_images: In the differential diagnostic imaging performed at 2 years, an 18F-FDG-PET showed reduced tracer uptake in the temporal cortex, posterior cingulate, and precuneus, consistent with AD pathology (Figures 2A-D). A 123I-FP-CIT-SPECT showed abundant tracer uptake in the right putamen and lower uptake in the left putamen (Figure 2E).