case_images: PMC11732205_01
case_images: Clinical images of nasal tip necrosis in patients 1 and 2. Patient 1 day 2 (A) and day 7 (B); Patient 2 day 10 (C) and day 14 (D).
case_images: gr1.jpg
case_images: PMC11732205_02_gr1.jpg
case_images: fig1
case_images: A 77-year-old woman presented to her outpatient dermatologist with a 2-week history of nontender acute onset progressive nasal tip necrosis (Fig 1, C). On examination, there was a pink plaque with hemorrhagic crust on the nasal tip with no other areas of involvement (Fig 1, D).
case_images: Histopathologic findings of the 2 reported cases. A, Punch biopsy of nose in patient 1 demonstrates ulceration with underlying sebaceous gland necrosis and brisk acute inflammation (20x, hematoxylin-eosin). B, VZV immunohistochemical staining was positive (20x). C, Demodex mite (40x, hematoxylin-eosin). D, Punch biopsy of nasal tip in patient 2 demonstrates necrosis of follicles and sebaceous glands (20x, hematoxylin-eosin). E, VZV immunostaining positive (20x).
case_images: gr2.jpg
case_images: PMC11732205_02_gr2.jpg
case_images: fig2
case_images: A biopsy performed from the nasal tip showed prominent folliculosebaceous gland necrosis with acute inflammation (Fig 2, D). periodic acid-Schiff, AFB, and herpes simplex virus 1/2 stains were negative. VZV PCR was not collected, but VZV immunohistochemical stain of the biopsy was positive (Fig 2, E).
case_images: PMC11732205_02
case_images: Clinical images of nasal tip necrosis in patients 1 and 2. Patient 1 day 2 (A) and day 7 (B); Patient 2 day 10 (C) and day 14 (D).
case_images: gr1.jpg
case_images: PMC11732205_02_gr1.jpg
case_images: fig1
case_images: A 77-year-old woman presented to her outpatient dermatologist with a 2-week history of nontender acute onset progressive nasal tip necrosis (Fig 1, C). On examination, there was a pink plaque with hemorrhagic crust on the nasal tip with no other areas of involvement (Fig 1, D).
case_images: Histopathologic findings of the 2 reported cases. A, Punch biopsy of nose in patient 1 demonstrates ulceration with underlying sebaceous gland necrosis and brisk acute inflammation (20x, hematoxylin-eosin). B, VZV immunohistochemical staining was positive (20x). C, Demodex mite (40x, hematoxylin-eosin). D, Punch biopsy of nasal tip in patient 2 demonstrates necrosis of follicles and sebaceous glands (20x, hematoxylin-eosin). E, VZV immunostaining positive (20x).
case_images: gr2.jpg
case_images: PMC11732205_02_gr2.jpg
case_images: fig2
case_images: A biopsy performed from the nasal tip showed prominent folliculosebaceous gland necrosis with acute inflammation (Fig 2, D). periodic acid-Schiff, AFB, and herpes simplex virus 1/2 stains were negative. VZV PCR was not collected, but VZV immunohistochemical stain of the biopsy was positive (Fig 2, E).