case_images: PMC3420746_01
case_images: CT chest showing mediastinal lymphadenopathy and bilateral axillary enlarge lymph nodes.
case_images: CRIM.HEMATOLOGY2011-385408.001.jpg
case_images: PMC3420746_01_CRIM.HEMATOLOGY2011-385408.001.jpg
case_images: fig1
case_images: CT scan of the thorax, abdomen, and pelvis revealed multiple symmetrically enlarged lymph nodes in the mediastinum and axilla (Figure 1) and splenomegaly.
case_images: (a) Showing lymph node with vague nodularity morphology as indicated by the arrows (magnification 40x). (b) shows multinucleated (classical) Reed-Stemberg cell. (40x magnification).
case_images: CRIM.HEMATOLOGY2011-385408.002.jpg
case_images: PMC3420746_01_CRIM.HEMATOLOGY2011-385408.002.jpg
case_images: fig2
case_images: Lymph node biopsy demonstrated a vague nodular pattern (Figure 2(a)) composed of numerous small cells and large atypical Reed-Sternberg cells (Figure 2(b)) within the nodules and outside of germinal centers; rare eosinophils and neutrophils were noted.
case_images: (a) Immunohistochemistry stain showing RS cells positive for CD30 (magnification 40x). (b) Immunohistochemistry stain showing RS cells positive for CD20 (magnifications 40x).
case_images: CRIM.HEMATOLOGY2011-385408.003.jpg
case_images: PMC3420746_01_CRIM.HEMATOLOGY2011-385408.003.jpg
case_images: fig3
case_images: Immunohistochemical stains indicated the RS cells being positive for CD30 (Figure 3(a)) and CD20 (Figure 3(b)) and negative for CD15 (Figure 4(a)) and lymphocyte common antigen (Figure 4(b)).
case_images: (a) shows large atypical lymphocyte identify by the arrow negative for CD15 (magnification 40x). (b) Immunohistochemistry showing RS cells negative for lymphocyte common antigen (LCA) (magnification 40x).
case_images: CRIM.HEMATOLOGY2011-385408.004.jpg
case_images: PMC3420746_01_CRIM.HEMATOLOGY2011-385408.004.jpg
case_images: fig4
case_images: Immunohistochemical stains indicated the RS cells being positive for CD30 (Figure 3(a)) and CD20 (Figure 3(b)) and negative for CD15 (Figure 4(a)) and lymphocyte common antigen (Figure 4(b)).