case_images: PMC10520397_01
case_images: PMC10520397_02
case_images: Genogram, pathology, and electropherogram of the examined patient. (A) The genogram showing an isolated PJS patient. Roman numerals indicate generations and Arabic numerals reveal individuals. Squares = males, circles = females. The affected individuals are denoted by solid symbols and unaffected individuals are represented by open symbols. The index patient is indicated by an arrow. (B) View of tissue sections stained with hematoxylin-eosin of gastrointestinal polyp specimens, confirming hamartomatous polyps. (C) Sanger sequencing revealing a heterozygous substitution new mutation, in 5 exon structure of STK11 gene
case_images: GHFBB-16-341-g002.jpg
case_images: PMC10520397_02_GHFBB-16-341-g002.jpg
case_images: F2
case_images: Also, the 5-year-old son of this patient also based on evidence and clinical symptoms, such as the presence of pigment in both palms as well as in the sole of the right foot, is going through the early stages of this syndrome (Figure 2A). The cut tissue samples were sent to the pathology department by the surgeon and the samples were stained with hematoxylin-eosin, and finally confirmed by three expert pathologists (Figure 2B).