case_images: PMC6489645_01
case_images: Immunohistochemistry of the patient's bone marrow: mature, and small lymphocytic (hematoxylin-eosin staining, H&E). CD20, CD23, SIg, Bcl-2, and PAX-5 were positive; CD5, LEF-1, Bcl-6, CD10, SOX-11, and CyclinD1 were negative, Ki-67 staining revealed a proliferative index of 10% (Scan 10x40).
case_images: OTT-12-2937-g0001.jpg
case_images: PMC6489645_01_OTT-12-2937-g0001.jpg
case_images: F0001
case_images: B virus-deoxyribonucleic acid (HBV-DNA) and EBV were negative. Bone marrow pathology indicated that CD20, PAX-5, CD23, SIg, and Bcl-2 were positive; SOX-11, CD3, CD5, MPO, CD34, CD10, Bcl-6, MUM-1, LEF-1 or CyclinD1 were negative, and Ki-67 staining revealed a proliferative index of 10% (Figure 1).
case_images: HBV-DNA and EBV-DNA were detected by the patient. In October 2016, HBV-DNA of the patient was raised to 2.656x10^5 copy/mL, so far, EBV-DNA was still negative.. Abbreviations: CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; MCL, mantle cell lymphoma; HBV-DNA, hepatitis B virus-deoxyribonucleic acid; EBV-DNA, Epstein-Barr virus-deoxyribonucleic acid.
case_images: OTT-12-2937-g0002.jpg
case_images: PMC6489645_01_OTT-12-2937-g0002.jpg
case_images: F0002
case_images: After that his superficial lymphadenopathy disappeared, but was found with HBsAg (+), HBsAb (-), HBeAg (-), HBeAb (+) and HBcAb (+), and HBV-DNA rose to 2.656x10^5 copy/mL, and EBV was still negative (Figure 2).
case_images: Immunohistochemistry of the patient's intestinal biopsy (The arrow point to intestinal tumor tissue): CD5, CyclinD1, CD20, and SOX-11 were positive; CD10, CD23, and Bcl-6 were negative, Ki-67 staining revealed a proliferative index of 45% (Scan 10x40).
case_images: OTT-12-2937-g0003.jpg
case_images: PMC6489645_01_OTT-12-2937-g0003.jpg
case_images: F0003
case_images: IHC of intestinal biopsy showed positive CD5, CyclinD1, CD20, SOX-11, and CD21, and negative cytokeratin (CK), LEF-1, CD23, Bcl-6, MUM1, CD10, and CD3, Ki-67 staining revealed a proliferative index of 45% (Figure 3), t(11;14) of intestinal biopsy was detected by fluorescence in situ hybridization.