case_images: PMC11817084_01
case_images: Initial presentation of Lateral thighs before calciphylaxis treatment.
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case_images: Two weeks later, she developed another ulcer, which was measured as 2 x 3 cm on her left thigh and was managed with the same treatment (Figure 1).
case_images: (a) Epidermal necrosis with dermal inflammatory infiltrate. (b) Inflammatory infiltrate in deep dermis and subcutis. Note: Microscopic examination of a tissue sample from a lesion shows full-thickness epidermal necrosis and ulceration with associated surface neutrophilic crust (a). The dermis contains a patchy mixed lymphohistiocytic inflammatory infiltrate with perivascular and periadnexal accentuation, with focal extension into the subcutis (b). No calcium deposition, fibrinoid necrosis of vessels, or well-defined granulomas are seen.
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case_images: The second biopsy revealed no evidence of calcium deposition or necrosis (Figure 2a,b).
case_images: Lateral thighs after six months of calciphylaxis treatment.
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case_images: To facilitate further ulcer healing, the total treatment duration with IV STS was continued for 6 months (Figure 3).