case_images: PMC10702496_01
case_images: Clinical and therapeutic course of the patient. ENKTL, extranodal NK/T-cell lymphoma, MP, methylprednisolone, CTX, cytoxan, IVIg, intravenous immunoglobulins, DXM, dexamethasone, MTX, methotrexate, VP16, vepeside, PET-CT, positron emission tomography/computed tomography.
case_images: fneur-14-1283874-g0001.jpg
case_images: PMC10702496_01_fneur-14-1283874-g0001.jpg
case_images: F1
case_images: The details of the subsequent clinical course are outlined in timeline form in Figure 1.
case_images: Positron emission tomography/computed tomography scans. A positron emission tomography/computed tomography scan shows multiple slightly fluorodeoxyglucose-avid subcutaneous fat tissue lesions scattered throughout the body (SUVmax of 1.6). (A) Thoracic wall (arrow); (B) abdominal wall (arrow); (C) pelvic wall (arrow).
case_images: fneur-14-1283874-g0002.jpg
case_images: PMC10702496_01_fneur-14-1283874-g0002.jpg
case_images: F2
case_images: PET-CT gave a very interesting finding of hypermetabolism in the subcutaneous fat tissue all over the body with a slightly elevated standard uptake value (SUV) maximum of 1.6 (Figure 2).
case_images: Immunohistochemical staining. (A) Histological findings of the subcutaneous fat tissue (hematoxylin-eosin: A, x 200), showing distended vessels filled with atypically large lymphoid cells, causing vessel occlusion (arrow). Infiltration of atypical lymphoid cells could also be observed in the subcutaneous fat tissue. (B-E) Immunohistochemical staining was positive for CD20 (B, x 100), CD34 (C, x 100), EBER (D, x 100), granzyme B (E, x 100). F: Ki-67 index 80% (F, x 100). Pathological figures are provided by the Pathology Department, Peking Union Medical College Hospital.
case_images: fneur-14-1283874-g0003.jpg
case_images: PMC10702496_01_fneur-14-1283874-g0003.jpg
case_images: F3
case_images: TIA-1(+), and EBER (+), which consisted of the diagnosis of ENKTL (Figure 3).