case_images: PMC11369897_01
case_images: The axial abdominal CT enhanced scan revealed an inhomogeneous low-density lesion located in the uncinate process of the pancreas (white arrow), exhibiting a distinct boundary, slight enhancement in the arterial phase (A), obvious enhancement in the venous phase (B) and iso- to hyper-density in the delayed phase (C). Axial abdominal MRI plain scan showed a cystic and solid mass (white arrow), low intensity in T1WI (D), iso- to high-intensity in T2WI and DWI (E, F), and patchy cystic area could be seen inside. Axial abdominal MR enhanced scan showed the lesion (white arrow) had obvious progressive enhancement (G-I).
case_images: fonc-14-1418244-g001.jpg
case_images: PMC11369897_01_fonc-14-1418244-g001.jpg
case_images: f1
case_images: Additionally, patchy areas of non-enhancement were observed within the lesion ( Figure 1 ).
case_images: Microscopic examination under low magnification (A) and high magnification (B) revealed a distinct boundary between the pancreatic hamartoma and the normal pancreas, with no true capsule. The lesion was composed of disorganized ductal cells and acinar cells embedded within a delicate fibrous stroma. Immunohistochemical staining showed CK7 (C), CK19 (D) and beta-catenin membrane (E) positive, respectively. (F) illustrated the low expression of ki67.
case_images: fonc-14-1418244-g002.jpg
case_images: PMC11369897_01_fonc-14-1418244-g002.jpg
case_images: f2
case_images: Microscopic examination showed the lesion to be composed of well-differentiated pancreatic acini and disorganized ducts, surrounded by a fibrotic stroma ( Figure 2 ).