case_images: PMC11783276_01
case_images: Schematic diagram showing treatment record of the patient.
case_images: oyae166_fig1.jpg
case_images: PMC11783276_01_oyae166_fig1.jpg
case_images: F1
case_images: The final diagnosis was stage IV squamous cell lung carcinoma (Figure 1).
case_images: Next-generation sequencing findings for the tumor tissue sample. Diagrams showed the DNA seq around the breaking point of TFG-MET rearrangement.
case_images: oyae166_fig2.jpg
case_images: PMC11783276_01_oyae166_fig2.jpg
case_images: F2
case_images: The TFG-MET rearrangement had breakpoints in TFG exon 6 and MET exon 15, retaining the complete regulatory dimerization domain of TFG and the intact kinase domain of MET, which could produce mature TFG-MET fusion transcripts (Figure 2). To determine the expression status of c-MET protein, we performed IHC and found positive c-MET expression (Figure 2).
case_images: CT scans illustrating the changes in primary focal of left lung and metastatic lymph nodes over time. (A) Primary lesion at the left lung. (B) Right supraclavicular lymph node: 20220518:3.2 x 2.7 cm, 20220727:2.5 x 2.1cm, 20230404:2.3 x 1.9 cm.
case_images: oyae166_fig3.jpg
case_images: PMC11783276_01_oyae166_fig3.jpg
case_images: F3