case_images: PMC11324270_01
case_images: Computed tomography (CT) images. a The red arrow indicated a ground-glass opacity (GGO) lesion in the left upper lobe. b The yellow arrow indicated a solid nodule with irregular high-density shadows in the dorsal segment of the right lower lobe. c Both lungs showed improved lung markings and increased pulmonary clarity.
case_images: cro-2024-0017-0001-540355_F01.jpg
case_images: PMC11324270_01_cro-2024-0017-0001-540355_F01.jpg
case_images: F1
case_images: High-resolution computed tomography (HRCT) revealed a ground-glass opacity lesion (tumor A) in the left upper lobe (LUL, 34 x 24 mm) and a solid nodule (tumor B) with irregular high-density shadows in the dorsal segment of the right lower lobe (RLL, 19 x 13 mm) (Fig. 1). HRCT scans revealed improved lung markings and increased pulmonary clarity (Fig. 1).
case_images: a The mass in the left upper lobe showed acinar and papillary subtype (H&E, x200). b The mass in the right lower lobe showed acinar and lepidic subtype (H&E, x200).
case_images: cro-2024-0017-0001-540355_F02.jpg
case_images: PMC11324270_01_cro-2024-0017-0001-540355_F02.jpg
case_images: F2
case_images: Histopathology exhibited that tumor A was acinar and papillary subtype, whereas tumor B was acinar and lepidic subtype (Fig. 2).
case_images: Molecular pathological examination in multiple pulmonary nodules by ARMS-PCR. MET Ex14 skipping (a) and PIK3CA (p.E545K) mutation (b) testing in the left upper lobe; KRAS exon2 (p.G12S/D) mutation testing in the right lower lobe (c).
case_images: cro-2024-0017-0001-540355_F03.jpg
case_images: PMC11324270_01_cro-2024-0017-0001-540355_F03.jpg
case_images: F3
case_images: The tumor A harbored the double mutation of MET ex14 skipping and PIK3CA (p.E545K), while the tumor B contained the mutation of the KRAS exon 2 (p.G12S/D) (Fig. 3).