case_images: PMC4591341_01
case_images: Portrait of the patient before, during and after treatment.. (A) The patient is shown as a healthy young adult. (B) Before treatment (month 0). (C) After treatment with fluconazole and terbinafine (month 18). (D) After 14 months without therapy (month 32).
case_images: pntd.0003984.g002.jpg
case_images: PMC4591341_01_pntd.0003984.g002.jpg
case_images: pntd.0003984.g002
case_images: He complained of grotesque facial deformity (Fig 2), dysarthria, hypersalivation, and incapacity to eat properly. The patient is free of relapse after 14 months without antifungal therapy (Fig 2D).
case_images: Histopathology.. Histopathological picture of hyphae of Entomophthorales after KOH-staining (A), after hematoxylin eosin stain (HE-stain) (B and C), and after Grocott-Gomori's methenamine silver stain (GMS-stain) (D). The pauci-septated, right-angled branching fungal hyphae have an irregular diameter of 5-12 mum with drumstick-like distended ends (A). The "Splendore-Hoeppli phenomenon" is characterized by a peri-hyphal amorphous eosinophilic material (B). Fungal hyphae are visible in transversal (C) or longitudinal cuts (D).
case_images: pntd.0003984.g003.jpg
case_images: PMC4591341_01_pntd.0003984.g003.jpg
case_images: pntd.0003984.g003
case_images: Histopathology revealed fungal hyphae suggestive for Conidiobolus sp. (Fig 3A, 3C and 3D) and the Splendore-Hoeppli phenomenon (Fig 3B).
case_images: Algorithm for the staging of rhinoentomophthoromycosis.. This algorithm is based on the clinical presentation of suspected/confirmed cases of rhinoentomophthoromycosis and the time since the onset of the first symptoms. The presence of a nodule at the nostril or invasion of facial tissue is the cornerstone to differentiate between early and intermediate disease.
case_images: pntd.0003984.g004.jpg
case_images: PMC4591341_01_pntd.0003984.g004.jpg
case_images: pntd.0003984.g004