case_images: PMC9874289_01
case_images: PMC9874289_02
case_images: Heat maps showing the volume of brain structures of the patient with juvenile Huntington's disease at 18 years (t1) and 21 years (t2). Brain structures were clustered in seven regions (summary, frontal lobe, temporal lobe, parietoccipital lobe, limbic and insular cortex, subcortical region, and the cerebellum). The blue-to-red scale indicates lower to higher intensity levels based on a Z-score of normalized volumes for each structure. Red/orange squares represent that the patient's structure volume is higher than its mean volume in controls, and yellow/blue squares represent that the patient's structure volume is lower than its mean volume in controls.
case_images: fneur-13-1089193-g0001.jpg
case_images: PMC9874289_02_fneur-13-1089193-g0001.jpg
case_images: F1
case_images: The cerebellum was spared from atrophy in both t1 and t2 (Figure 1).
case_images: Brain magnetic resonance imaging segmentation maps of the patient with juvenile Huntington's disease at 18 years and 21 years. (A, B) Whole brain images (in red) of the patient in axial, coronal, and sagittal planes show an atrophy of the striatum at 18 years (A), progressing to a more diffuse process of atrophy, including subcortical structures and neocortical areas like the frontal and parietal lobes at 21 years (B). White matter volume was relatively preserved as compared to gray matter. (C, D) Cerebellum images of the patient in axial, coronal, and sagittal planes show a normal cerebellar volume and a volumetric stability at 18 years (C) and 21 years (D). The Roman numerals of the cerebellar lobules were added. CI, Crus I; CII: Crus II.
case_images: fneur-13-1089193-g0002.jpg
case_images: PMC9874289_02_fneur-13-1089193-g0002.jpg
case_images: F2
case_images: There was no marked difference in the volume of distinct lobules of cerebellum in t1 and t2 (Figure 2).