case_images: PMC11091706_01
case_images: Chest CT imaging on admission showed multiple nodules and masses with calcification and cysts in both lungs (A). A CT scan of the chest 10 years earlier (B) already showed the presence of calcified nodules, which were smaller than on the present CT images.
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case_images: Some nodules were calcified, some cavitated and accompanied by cystic changes around them (Fig. 1A). Comparative analysis of previous CT images revealed a notable escalation in the number and size of nodules over the last decade (Fig. 1A and B).
case_images: 18F-FDG PET/CT showed varying degrees of FDG uptake in non-calcified areas of several nodes.
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case_images: Given the suspicion of malignancy, 18F-FDG PET/CT was conducted, revealing markedly heightened 18F-FDG uptake in the largest nodule in the left upper lung lobe (maximum standard uptake value, 5.7) (Fig. 2).
case_images: Transthoracic ultrasonography revealed a lesion in contact with the pleura of the left lung (white arrows).
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case_images: Chest ultrasonography revealed a mass in the left lung, located in the left anterior thoracic region and in contact with the pleura, measuring 5.2 x 4.0 cm. (Fig. 3).
case_images: Histopathological findings of pulmonary nodules collected by US-guided biopsy are shown. Hematoxylin-eosin staining (A) shows abundant amorphous eosinophilic material with focal calcification displacing the lung parenchyma. Congo red staining (B) shows that these amorphous eosinophils are pink or red, suggesting amyloidosis.
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case_images: Histopathologic analysis of the biopsy specimen revealed nodular amyloid deposits in the alveolar space with no evidence of malignant cells or microorganisms. (Fig. 4).