case_images: PMC6109551_01
case_images: CT scan showing (a) 15 cm splenomegaly after CLL diagnosis in 2006. (b) CT scan in 2013 showing increased massive splenomegaly (28 cm) with splenic infarct and hepatomegaly, after PMF diagnosis. (c) Bone marrow biopsy showing hypercellular bone marrow with fibrosis, consistent with the diagnosis of myelofibrosis.
case_images: CRIHEM2018-7426739.001.jpg
case_images: PMC6109551_01_CRIHEM2018-7426739.001.jpg
case_images: fig1
case_images: Bone marrow biopsy revealed a hypercellular bone marrow with increased reticulin stain and fibrosis (Figure 1). Imaging studies showed massive splenomegaly (Figure 1, about 28 cm on CT scan).
case_images: Karyotype showing trisomy 9, t (1; 6).
case_images: CRIHEM2018-7426739.002.jpg
case_images: PMC6109551_01_CRIHEM2018-7426739.002.jpg
case_images: fig2
case_images: A karyotype from the bone marrow showed chromosomal abnormalities of trisomy 9 (+9) and t (1; 6) (Figure 2).