case_images: PMC11291377_01
case_images: Fundus fluorescein angiography (FFA) displayed multifocal hyperfluorescent lesions at the level of retinal pigment epithelium pooled into the sub-neurosensory retinal space (arrows).
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case_images: F1
case_images: The FFA images demonstrated multiple focal areas of pinpoint hyperfluorescence, along with pooling indicative of neurosensory detachment (NSD) and disc leakage in both eyes (Figure 1).
case_images: Patient's first visit. (A,B): SS-OCT showed the neurosensory retinal detachment (NSD) in the right eye (asterisk), choroid folds and thickened choroid in both eyes. The subfoveal choroid thickness (SFCT) were 800 mum in the right eye and 836 mum in the left eye. (C,D): Ultrasound B scan showed thickening of choroid and clear eyeballs. (E-H): Both eyes showed signs of iris synechiae and anterior uveitis with fibrin formation. (I,J): Patient's fundus image was basically normal.
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case_images: F2
case_images: The SS-OCT images of the patient revealed NSD in the right eye (Figure 2A), as well as choroidal folds and thickened choroid in both eyes (Figures 2A, B). Ultrasound B-scan imaging revealed a clear vitreous body but demonstrated choroidal thickening in both eyes (Figures 2C, D). Ophthalmic anterior segment imaging displayed signs of iris synechiae and anterior uveitis, along with fibrin formation (Figures 2E-H). However, the patient's fundus imaging appeared basically normal (Figures 2I, J).
case_images: Patient's condition after discontinuing donafenib 1 week. (A-D): The pupil and iris had synechiae in both eyes, and the anterior uveitis of left eye. (E,F): Patient's fundus image showed choroidal depigmentation, sun-set fundus.
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case_images: F3
case_images: Examination revealed synechiae involving the pupil and iris in both eyes, and anterior uveitis was observed in the left eye (Figures 3A-D). His fundus image showed choroidal depigmentation as sun-set fundus (Figures 3E, F).
case_images: Patient's condition after discontinuing donafenib and receiving oral glucocorticoid and neocyspin for 3 months. (A-D): The obvious red-light reflex suggested that the fundus of the patient had a sunset-glow change, and the lens surface of the left eye had anterior synechiae. (E,F): A pale nerve surrounded by red-orange choroidal depigmentation was referred to as a "sunset-glow" fundus. (G,H): SS-OCT showed retina flatted. The choroid was thinned out and the choroidoscleral border was visible. The subfoveal choroid thickness (SFCT) was 261 mum in the right eye and 263 mum in the left eye.
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case_images: F4
case_images: Ophthalmic anterior segment imaging showed the obvious red-light reflex, suggesting fundus of the patient had a sunset-glow change, and the lens' surface of the left eye had anterior synechiae (Figures 4A-D). The fundus imaging depicted a pale optic nerve surrounded by red-orange choroidal depigmentation, characteristic of a "sunset-glow" fundus appearance (Figures 4E, F). He responded well to the oral corticosteroid therapy, as evidenced by the resolution of exudative detachment and diminishing fluid observed in the SS-OCT (Figures 4G, H).