case_images: PMC6190876_01
case_images: Study design.
case_images: fneur-09-00816-g0001.jpg
case_images: PMC6190876_01_fneur-09-00816-g0001.jpg
case_images: F1
case_images: The investigator sets the cathode facing the ischemic injury (C3 or C4 according to the 10-20 system) and the anode facing the contralateral supra-orbital area (Figure 1).
case_images: tDCS device and tDCS electrode positioning. In case of left MCA stroke, in order to hyperpolarize the ischemic penumbra, the cathode (in blue) faces the ischemic injury (C3, 10-20 system) and the anode (in red) faces the contralateral supra-orbitary area.
case_images: fneur-09-00816-g0002.jpg
case_images: PMC6190876_01_fneur-09-00816-g0002.jpg
case_images: F2
case_images: The device delivers 1.5 mA (with 30 s for ramping up and ramping down) of cathodal direct current through the two sponge coated electrodes (electrodes size: 5 x 7 cm2; Figure 2).
case_images: Timelines of active tDCS (left) and sham tDCS (right), and treatment protocol.
case_images: fneur-09-00816-g0003.jpg
case_images: PMC6190876_01_fneur-09-00816-g0003.jpg
case_images: F3
case_images: In the sham condition, the device delivers 98 s of current including 30 s for ramping at the beginning and end of each session, in order to keep the blinding procedure (Figure 3).
case_images: Timeline of procedures. IA, intra-arterial; IV, intravenous.
case_images: fneur-09-00816-g0004.jpg
case_images: PMC6190876_01_fneur-09-00816-g0004.jpg
case_images: F4
case_images: The experimenter notes every significant event: time of stroke onset, time of hospital arrival, time of first MRI, time of IV thrombolysis, and/or endovascular recanalization, time of each tDCS session (Figure 4).