case_images: PMC11372405_01
case_images: (a) Biomicroscopic photograph of the nasally located squamous cell carcinoma in situ in case. (b) Histopathological examination revealed an acanthotic epidermis with enlarged atypical keratinocytes and mitotic figures that reach full-thickness atypia namely squamous cell carcinoma in situ. (c) Anterior segment of the eye at the last visit.
case_images: BEJ-9-161-g001.jpg
case_images: PMC11372405_02_BEJ-9-161-g001.jpg
case_images: F1
case_images: Follow-up visits were uneventful, and no recurrence was detected in a follow-up of 4 years (Fig. 1c) in Case 1 and for 5 years in Case 2.
case_images: PMC11372405_02
case_images: (a) Biomicroscopic photograph of the nasally located squamous cell carcinoma in situ in case. (b) Histopathological examination revealed an acanthotic epidermis with enlarged atypical keratinocytes and mitotic figures that reach full-thickness atypia namely squamous cell carcinoma in situ. (c) Anterior segment of the eye at the last visit.
case_images: BEJ-9-161-g001.jpg
case_images: PMC11372405_02_BEJ-9-161-g001.jpg
case_images: F1
case_images: Follow-up visits were uneventful, and no recurrence was detected in a follow-up of 4 years (Fig. 1c) in Case 1 and for 5 years in Case 2.
case_images: Nasally located whitish lesion in Case 2.
case_images: BEJ-9-161-g002.jpg
case_images: PMC11372405_02_BEJ-9-161-g002.jpg
case_images: F2
case_images: Slit lamp examination of the left eye revealed a whitish, and vascularized conjunctival lesion extending to the cornea (Fig. 2).
case_images: PMC11372405_03
case_images: (a) Nasally located limbal mass extending to the cornea. (b) Anterior segment optic coherence tomography of the lesion demonstrating hyperreflective epithelial lesion on the cornea and on the conjunctiva. (c) Early postoperative photograph of the eye.
case_images: BEJ-9-161-g003.jpg
case_images: PMC11372405_03_BEJ-9-161-g003.jpg
case_images: F3
case_images: On slit lamp examination a mass on the nasal perilimbal region extending through almost the whole cornea was detected (Fig. 3a). On anterior segment optic coherence tomography evaluation of the lesion epithelial thickening on both the conjunctival and corneal parts which were suggestive of OSSN was detected (Fig. 3b). Total excision of the lesion, corneal epitheliectomy with alcohol, cryotherapy to the conjunctival borders, and adjunctive ocular surface reconstruction with amniotic membrane under local anesthesia were performed (Fig. 3c).
case_images: (a, b) Histopathologic examination revealed maturation and misalignment of keratinocytes with moderate atypia in the squamous epithelium. (c) Focal proliferative activity increases in keratinocytes (Ki-67). (d) p53 positivity is evident.
case_images: BEJ-9-161-g004.jpg
case_images: PMC11372405_03_BEJ-9-161-g004.jpg
case_images: F4
case_images: Histopathologic examination revealed maturation and misalignment of keratinocytes with moderate atypia in the squamous epithelium (Figs. 4a and b). Fig. 4Ki-67) and p53 positivity (Fig. 4d). Findings were compatible with squamous intraepithelial neoplasia II-III.