case_images: PMC11176473_01
case_images: PMC11176473_02
case_images: Flexible nasopharyngoscopy examination of nasopharynx. (A, B) In case 1, a prominent mass is observed on the nasopharynx (Yellow headarrow). The mass extends into posterior nasal cavity. The right nasal cavity shows postoperative adhesions (Black headarrow). (C, D) After 2.5 years of post-treatment follow-up, no tumor recurrence is observed in the nasopharyngeal region. (E, F) In Case 2, a mass is identified in the nasopharynx, characterized by an irregular surface (Yellow headarrow). (G, H) following an 8-month post-treatment surveillance, there is no evidence of tumor recurrence in the nasopharyngeal area.
case_images: fonc-14-1384913-g001.jpg
case_images: PMC11176473_02_fonc-14-1384913-g001.jpg
case_images: f1
case_images: It extends into the right posterior nasal cavity, and the orifices of the pharyngeal recess and pharyngeal orifice of the Eustachian tube cannot be visualized ( Figures 1A, B ). A 2.5-year follow-up post-treatment showed no evidence of tumor recurrence in the nasopharynx ( Figures 1C, D ). However, adhesive changes were noted in the right nasal cavity caused by radiation therapy ( Figure 1D , Black arrowhead). Additionally, the left pharyngeal recess shows signs of narrowing ( Figures 1E, F ). During the 8-year follow-up post-treatment, no recurrence of the nasopharyngeal tumor was observed ( Figures 1G, H ).
case_images: Magnetic Resonance Imaging (MRI) of the nasopharynx. (A, B) A polgs of Case 1 on MRI. A mass measuring approximately 38 * 32 mm was observed on the right side of the nasopharynx (Red dash line). Enhanced scanning reveals significant and uneven enhancement. (C, D) At 2.5 years post-treatment reveals the absence of any abnormal signal changes in the nasopharynx (Red arrow show). (E, F) An irregular mass measuring approximately 24 x 20 x 19 mm on the right side of the nasopharynx (Red dash line). Enhanced scan indicating significant and uneven enhancement of the nasopharyngeal mass. (G, H) Follow-up at 8 months post-treatment showing no abnormal signal changes in the nasopharynx (Red arrow show).
case_images: fonc-14-1384913-g002.jpg
case_images: PMC11176473_02_fonc-14-1384913-g002.jpg
case_images: f2
case_images: Enhanced scanning demonstrates significant enhancement with relatively clear boundaries ( Figures 2A, B ). A 2.5-year follow-up post-treatment revealed no abnormal signal changes in the nasopharynx ( Figures 2C, D ). Enhanced scanning reveals uneven enhancement in the affected lymph nodes ( Figures 2E, F ). At an 8-month follow-up post-treatment, no abnormal signal changes were observed in the nasopharynx ( Figures 2G, H ).
case_images: Histopathological features of nasopharyngeal hyalinizing clear cell carcinoma. (A) HE staining shows the tumor grows in a nest pattern and cord pattern. (B) Tumor cells characterized by rich cytoplasm, presenting as either transparent or lightly eosinophilic, and featuring round cell nuclei. (C-G) Immunohistochemical analysis demonstrates positive staining for PCK, CK5/6, P40, P63, and CK7 in the tumor. (H) Ki67 immunostaining reveals a low proliferation index of 5% in the tumor, indicating a relatively low rate of cell proliferation. (I, J) PAS staining highlights abundant glycogen within tumor cells. (K, L) Fluorescence in situ hybridization (FISH) shows spit signals, indicating EWSR1 rearrangement (Yellow arrowhead).
case_images: fonc-14-1384913-g003.jpg
case_images: PMC11176473_02_fonc-14-1384913-g003.jpg
case_images: f3
case_images: Hematoxylin and Eosin (HE) staining reveals an epithelial-like tumor with transparent and acidophilic cytoplasm ( Figures 3A, B ). The immunohistochemical profile of the tumor revealed positive staining for PCK, CK5/6, P40, P63, CK7 ( Figures 3C-H ), while being negative for CK20, S100, SMA, SOX10, PAX8, CAIX and CD10 (Data not shown). Figures 3I, J ). FISH analysis confirmed EWSR1 gene rearrangement ( Figures 3K, L ).
case_images: Schematic of literature review. HCCC, hyalinizing clear cell carcinoma.
case_images: fonc-14-1384913-g004.jpg
case_images: PMC11176473_02_fonc-14-1384913-g004.jpg
case_images: f4
case_images: A comprehensive review of 44 cases of Primary Nasopharyngeal Hyalinizing Clear Cell Carcinoma (HCCC) is presented ( Figure 4 ).