case_images: PMC10711583_01
case_images: Colored fundus photographs of both eyes in Case 1. Wide-angle color fundus photographs show scalloped edges of the remaining posterior retina; foveal and peripapillary region appeared to be protected bilaterally. The patient has large, geographic, peripheral paving-stone - like areas of atrophy of the RPE and choriocapillaris, which gradually coalesce to form a characteristic scalloped border at the junction of normal and abnormal RPE.
case_images: BEJ-8-301-g001.jpg
case_images: PMC10711583_01_BEJ-8-301-g001.jpg
case_images: F1
case_images: In addition, the foveal region appeared to be protected bilaterally (Fig. 1).
case_images: (a) Fundus autofluorescence of both eyes in Case 1. Fundus autofluorescences show decreased autofluorescence correlated with chorioretinal atrophy areas and foveal region appeared to be protected bilaterally. (b) Fluorescein angiographies of both eyes in Case 1. Fluorescein angiographies show no leakage in macular area on the late phase of fluorescein angiography. Large choroidal vessels can be seen easily in areas of atrophy of the RPE and choriocapillaris.
case_images: BEJ-8-301-g002.jpg
case_images: PMC10711583_01_BEJ-8-301-g002.jpg
case_images: F2
case_images: Fundus autofluorescence demonstrated hypo-autofluorescence areas of chorioretinal atrophy (Fig. 2a). There was no leakage in macular area on the late phase of fluorescein angiography (FA) (Fig. 2b).
case_images: Baseline OCT images of both eyes in Case 1. OCTs demonstrate a thickening of the central fovea with intraretinal cystic spaces and flat subfoveal fluid bilaterally. Retinal outer segment cannot be seen in temporal to fovea in both eyes. The retinal outer segment is appeared to be protected in between optic disc and fovea in the left eye, but it cannot be seen nasal to fovea in the right eye.
case_images: BEJ-8-301-g003.jpg
case_images: PMC10711583_01_BEJ-8-301-g003.jpg
case_images: F3
case_images: In addition, the retinal outer segment could not be detected except the foveal region in both eyes (Fig. 3).
case_images: OCT images of both eyes after 2 months of lasting CAI therapy in Case 1. Bilaterally subretinal fluid seems to be decreased in OCT, but intraretinal cystic spaces change minimally.
case_images: BEJ-8-301-g004.jpg
case_images: PMC10711583_01_BEJ-8-301-g004.jpg
case_images: F4
case_images: After 2 months, subretinal fluid seems to be decreased bilaterally in OCT; however, there were no changes in BCVA (Fig. 4).
case_images: Colored fundus photographs of both eyes in Case 2. Colored fundus photographs show scalloped edges of the remaining posterior retina; foveal region appeared to be protected bilaterally. Clinically fundus examination of scalloped edges revealed multiple bone spicules in the retinal periphery with marked retinal and choroidal atrophy. Retinal and choroidal atrophies are severe when compared with Case 1.
case_images: BEJ-8-301-g005.jpg
case_images: PMC10711583_01_BEJ-8-301-g005.jpg
case_images: F5
case_images: The foveal region appeared to be protected bilaterally (Fig. 5).
case_images: Fluorescein angiographies of both eyes in Case 2. There is no leakage in the fovea on the late phase of fluorescein angiographies.
case_images: BEJ-8-301-g006.jpg
case_images: PMC10711583_01_BEJ-8-301-g006.jpg
case_images: F6
case_images: There was no leakage in the fovea on the late phase of FA (Fig. 6).
case_images: OCT images of both eyes in Case 2. OCT demonstrates a thickening of the central fovea with intraretinal cystic spaces in the right eye and lamellar macular hole in the left eye. Retinal outer segment cannot be detected except foveal region in both eyes.
case_images: BEJ-8-301-g007.jpg
case_images: PMC10711583_01_BEJ-8-301-g007.jpg
case_images: F7
case_images: In addition, the retinal outer segment could not be detected except for the foveal region in both eyes (Fig. 7).