case_images: PMC5138457_01
case_images: The polypoid lesion was identified as a whitish elevation covered with smooth surface. The polyp was successfully removed with endoscopic resection.
case_images: CRIPA2016-8646927.001.jpg
case_images: PMC5138457_01_CRIPA2016-8646927.001.jpg
case_images: fig1
case_images: The polyp was successfully removed with endoscopic resection (Figure 1).
case_images: Irregularly branched neoplastic glands covered with the nonneoplastic foveolar epithelium (H&E x40).
case_images: CRIPA2016-8646927.002.jpg
case_images: PMC5138457_01_CRIPA2016-8646927.002.jpg
case_images: fig2
case_images: Microscopically, the polyp was composed of irregularly branched neoplastic glands covered with the nonneoplastic foveolar epithelium (Figure 2).
case_images: Continuity between the neoplastic glands and the fundic glands, indicating that the tumor arouse from the fundic gland (H&E x100).
case_images: CRIPA2016-8646927.003.jpg
case_images: PMC5138457_01_CRIPA2016-8646927.003.jpg
case_images: fig3
case_images: Continuity between the neoplastic glands and the fundic glands was clearly identified, indicating that the tumor arose from the fundic glands (Figure 3).
case_images: Occasional neoplastic cells showing oxyntic cytoplasm (H&E x200).
case_images: CRIPA2016-8646927.004.jpg
case_images: PMC5138457_01_CRIPA2016-8646927.004.jpg
case_images: fig4
case_images: The tumor cells exhibited mildly enlarged atypical nuclei with occasional cells showing oxyntic cytoplasm (Figure 4).
case_images: Submucosal invasion with complete disruption of the muscularis mucosae (a) (desmin immunostain x40) and mild lymphocytic and fibroblastic stromal reaction (b) (H&E x200).
case_images: CRIPA2016-8646927.005.jpg
case_images: PMC5138457_01_CRIPA2016-8646927.005.jpg
case_images: fig5
case_images: The tumor invaded the submucosa with complete disruption of the muscularis mucosae and demonstrated mild lymphocytic and fibroblastic stromal reaction (Figures 5(a) and 5(b)).
case_images: The neoplastic glands are diffusely reactive for MUC6 (a) (MUC6 immunostain x200) and pepsinogen-I (b) (pepsinogen-I immunostain x200).
case_images: CRIPA2016-8646927.006.jpg
case_images: PMC5138457_01_CRIPA2016-8646927.006.jpg
case_images: fig6
case_images: Immunohistochemistry demonstrated that the neoplastic glands were strongly and diffusely reactive for MUC6 and pepsinogen-I (Figures 6(a) and 6(b)) and nonreactive for MUC2 and MUC5AC, confirming a gastric immunophenotype.