case_images: PMC8079212_01
case_images: Plain film reveals osteolytic metastases in the left humerus.
case_images: CRIPE2021-8826688.001.jpg
case_images: PMC8079212_01_CRIPE2021-8826688.001.jpg
case_images: fig1
case_images: A 12-year-old girl (no puberty) presented with localized pain of the left shoulder evolving for 9 months, and plain radiography done in the emergency showed osteolytic lesions without rupture of the cortex of the upper end of the left humerus (Figure 1) confirmed on computerized tomography (CT) scan.
case_images: Contrast-enhanced CT shows a heterogeneous density abdomino-pelvic tumor.
case_images: CRIPE2021-8826688.002.jpg
case_images: PMC8079212_01_CRIPE2021-8826688.002.jpg
case_images: fig2
case_images: Abdominal CT scan revealed a 10-cm diameter abdomino-pelvic mass of heterogeneous density without calcification (Figure 2), whose origin is difficult to assess.
case_images: Cytology of pediatric ovarian lymphoma: diffuse large B-cell lymphoma (40x).
case_images: CRIPE2021-8826688.003.jpg
case_images: PMC8079212_01_CRIPE2021-8826688.003.jpg
case_images: fig3
case_images: Immunohistochemistry indicated that the cells were positive for CD20 and CD45 and Ki67 (about 80%) but negative for CD3, BCL2, and BCL6 (Figures 3 and 4).
case_images: CD45 staining of the tumor cells (40x).
case_images: CRIPE2021-8826688.004.jpg
case_images: PMC8079212_01_CRIPE2021-8826688.004.jpg
case_images: fig4
case_images: Immunohistochemistry indicated that the cells were positive for CD20 and CD45 and Ki67 (about 80%) but negative for CD3, BCL2, and BCL6 (Figures 3 and 4).
case_images: Skeletal scintigraphy showing multiple bone metastases.
case_images: CRIPE2021-8826688.005.jpg
case_images: PMC8079212_01_CRIPE2021-8826688.005.jpg
case_images: fig5
case_images: The diagnosis made was a diffuse large B-cell lymphoma (DLBCL) of the left ovary with bone metastasis confirmed by bone scintigraphy which revealed multiple lesions with intensive radioactive accumulation in the left humerus, point of the left scapula, upper third of the left femur, the skull, and the second dorsal vertebra (Figure 5).