case_images: PMC10601614_01
case_images: a BMI trajectory of the girl. b Height-for-age trajectory of the girl. BMI, body mass index; LEPR, leptin receptor deficiency; MC4R, melanocortin-4 receptor; y, years; cm, centimetres; BMI SDS, body mass index standard deviation score; Leptin SDS, leptin standard deviation score. a Corrected for Tanner stage, sex, and BMI, according to Blum et al..
case_images: ofa-2023-0016-0005-531529_F01.jpg
case_images: PMC10601614_01_ofa-2023-0016-0005-531529_F01.jpg
case_images: F1
case_images: Hospital, her BMI SD score (SDS) decreased from +7.88 SD to +5.98 SD (-24.1% in BMI SDS, -8.52 kg/m2 in BMI, shown in Fig. 1) due to ongoing supportive treatment and a better understanding of her hyperphagic behaviour. Health-related quality of life was assessed at the end of this period at age 3 years, using the Pediatric Quality of Life Inventory (PedsQL, parents proxy-report version), which showed a low total score of 58.3 percentiles due to low scores on physical, emotional, and educational functioning. During this period, her BMI fluctuated without understanding the underlying cause (shown in Fig. 1). After 24 months of treatment, her BMI SDS decreased to +3.05 SD (obesity grade 1, -18.0% in BMI SDS, -1.46 kg/m2 in BMI, shown in Fig. 1).