case_images: PMC10730097_01
case_images: PMC10730097_02
case_images: Extensive cystic changes can be seen in tumor cell nests. Stained with hematoxylin and eosin.
case_images: cro-2023-0016-0001-533708_F01.jpg
case_images: PMC10730097_02_cro-2023-0016-0001-533708_F01.jpg
case_images: F1
case_images: An ipsilateral upper node dissection was performed and 1 out of 19 lymph nodes showed poorly differentiated non-keratinizing-cystic SCC (Fig. 1) metastasis without extracapsular extension (T0pN1M0), which may indicate tonsillar cancer, but histologic findings of tonsils biopsies were negative.
case_images: PMC10730097_03
case_images: a Lymph node metastasis of squamous cell carcinoma. Tumor cells show mainly basaloid morphology. Tumor cell nests show extensive central necrosis. Stained with hematoxylin and eosin. b Diffuse intensive p16 expression suggests HPV association. Immunohistochemistry for p16.
case_images: cro-2023-0016-0001-533708_F02.jpg
case_images: PMC10730097_03_cro-2023-0016-0001-533708_F02.jpg
case_images: F2
case_images: Fifty-two cervical lymph nodes were dissected and the histopathological examination revealed poorly differentiated SCC metastasis in five nodes (three on the right side and two on the left side) (Fig. 2a). Tumor cells were p16 positive and the presence of HPV16 was confirmed from tumor DNA (Fig. 2b).
case_images: PMC10730097_04