case_images: PMC10715754_01
case_images: T2-weighted MRI only shows pretreated metastasis lesion without any signs of leptomeningeal enhancement or enlargement of the ventricles. a 6 mm metastasis by the central part of lateral ventricle. b 5 mm nodule on the right basis pontis.
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case_images: F1
case_images: MRI only showed the two known metastases on the cerebellum and cerebrum without any signs of leptomeningeal enhancement or enlargement of the ventricles (Fig. 1).
case_images: a CSF cytology (Giemsa staining) showing atypical cells (x400). b CSF cytology (TTF-1 staining) showing TTF-1 positive (x400).
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case_images: F2
case_images: Although the initial CSF cytology only showed a few atypical cells, repeated testing eventually revealed positive with obvious signs of malignancy (Fig. 2a, b).
case_images: Treatment course and tumor markers.
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case_images: F3
case_images: Both lactate dehydrogenase (LDH) and sialyl SSEA-1 antigen (SLX), known as tumor markers because of the concordance with his disease burden, have decreased significantly since entrectinib was introduced (Fig. 3, 4).
case_images: A timeline summarizing the main events.
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case_images: F4
case_images: Both lactate dehydrogenase (LDH) and sialyl SSEA-1 antigen (SLX), known as tumor markers because of the concordance with his disease burden, have decreased significantly since entrectinib was introduced (Fig. 3, 4).
case_images: The FLAIR MRI shows the metastatic site on the right basis pontis has become smaller once entrectinib was initiated.
case_images: cro-2023-0016-0001-534549_F05.jpg
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case_images: F5
case_images: The head MRI showed the metastatic site on the right basis pontis had become smaller (Fig. 5).