case_images: PMC10903083_01
case_images: Skin changes and imaging in the patient with multicentric reticulohistiocytosis. (A) Skin lesions in the right inguinal region. (B) Mild swelling of the interphalangeal joints of both fingers of the patient, with no obvious deformation. (C) Mild bony changes at the edges of the interphalangeal joints indicated by the red arrow on the X-ray, and mild narrowing of the interphalangeal joint space. (D) MR scan of the sacroiliac joint, with the red arrow indicating lipid deposition in the hip joint. (E) MR scan of the sacroiliac joint, with the red arrow indicating lipid deposition in the hip joint. (F) Pelvic X-ray, with the red arrow indicating degenerative changes in the hip joint with decreased cystic density.
case_images: fimmu-15-1344313-g001.jpg
case_images: PMC10903083_01_fimmu-15-1344313-g001.jpg
case_images: f1
case_images: The texture was hard; it exhibited good mobility with no apparent adhesion with the underlying tissue, and there was no tenderness observed (Figure 1A). The distal interphalangeal joints of both hands were mildly swollen, with limited movement and tenderness (Figure 1B). Orthopantomographic radiography of both hands revealed mild bony changes at the edges of the interphalangeal joints and narrowing of the interphalangeal joint space (Figure 1C). MR scan of the sacroiliac joints revealed degenerative changes in the bilateral sacroiliac joints and localized lipid deposits in the sacrum and bilateral iliac joints (Figures 1D, E). Pelvic orthopantomography revealed degenerative changes in the hip joints (Figure 1F).
case_images: Histopathology and immunohistochemistry of the dermis of the patient with multicentric reticulohistiocytosis. (A) Mild atrophy of the epidermis, with a large number of histiocytes in the dermis, locally foamy (HE x 100). (B) Diffuse histiocyte infiltration in the dermis, accompanied by a large number of multinucleated giant cells in a "hairy glass"-like pattern, which is indicated with a red arrow (HE x 200). (C-J) Immunohistochemical staining for CD68 (diffuse +), vimentin (diffuse +), CD31 (diffuse +), and Vimentin (diffuse +). CD68 (diffuse +), vimentin (diffuse +), CD31 (diffuse +), LCA (CD45) (+), S-100 (-), CD1a (-), CD34 (-), and Ki-67 positivity of approximately 5%-10% (x 200).
case_images: fimmu-15-1344313-g002.jpg
case_images: PMC10903083_01_fimmu-15-1344313-g002.jpg
case_images: f2
case_images: By skin histopathology, diffuse histiocyte infiltration was seen in the dermis, with pink histiocytes, with a uniform morphology, and eosinophilic "hairy glass"-like multinucleated giant cells with clear borders (Figures 2A, B). Immunohistochemistry revealed CD68 (diffuse +), vimentin (diffuse +), CD31 (diffuse +), LCA (CD45) (+), S-100 (-), CD1a (-), CD34 (-), and Ki-67 positivity in approximately 5%-10% of the patients (Figures 2C-J).
case_images: Schematic diagram of the clinical course of the patient.
case_images: fimmu-15-1344313-g003.jpg
case_images: PMC10903083_01_fimmu-15-1344313-g003.jpg
case_images: f3
case_images: The clinical course of the patient is shown in Figure 3.