case_images: PMC10348747_01
case_images: beta-globin gene sequencing showing the point mutation at c.202G>A before HSCT (A) and a normal sequence after HSCT (B). The arrow shows the position of the mutation.
case_images: fimmu-14-1188058-g001.jpg
case_images: PMC10348747_01_fimmu-14-1188058-g001.jpg
case_images: f1
case_images: DNA sequencing of the globin genes were subsequently performed and identified a heterozygous mutation in Hbbeta codon 67, variant c.202G>A Val-Met ( Figure 1A , GenBank accession No. DNA sequencing of globin chains. Deferasirox was administered at 4 years of age because of iron overload, with a serum ferritin level >2000 ng/mL ( Supplementary Figure 1 ). Furthermore, the former mutation of Hbbeta was not detected using DNA resequencing ( Figure 1B , GenBank accession No.
case_images: Overview of the haplo-HSCT protocol.
case_images: fimmu-14-1188058-g002.jpg
case_images: PMC10348747_01_fimmu-14-1188058-g002.jpg
case_images: f2
case_images: As the patient did not have matched siblings or unrelated donors, he underwent haplo-HSCT with a myeloablative conditioning regimen ( Figure 2 ).