case_images: PMC11760995_01
case_images: Physical Exam and Dermatopathology Findings. (A-D) Cutaneous manifestations of dermatomyositis such a heliotrope and malar rash, shawl sign, angel's wing sign, and Gottron papules before anifrolumab therapy. (E-I) Significant improvement of cutaneous manifestations after eight weeks of anifrolumab therapy. (J, K) Skin biopsy H&E at (J) 2x and (K) 40x showing vacuolar interface dermatitis with increased mucin and dermal perivascular lymphoid inflammation. H&E, hematoxylin and eosin.
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case_images: PMC11760995_01_ACR2-7-e11792-g001.jpg
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case_images: The patient also had digital ulcerations, dilated nailfold capillaries, Gottron papules on his hands and knees, and proximal muscle weakness (Figure 1A-D). Dermatopathology showed vacuolar interface dermatitis with increased mucin and dermal perivascular lymphoid inflammation (Figure 1J and K). The patient was then treated with anifrolumab 300 mg IV every four weeks with significant improvement in cutaneous symptoms within eight weeks, including digital ulceration (Figure 1E-I).