case_images: PMC8384145_01
case_images: Fundus examination is not clear, and small patches of yellow-white lesions could be seen. (A) OD; (B) OS. Fundus fluorescein angiography shows retinal venous engorgement with fluorescein leakage and high fluorescence of the optic disc. (C) OD; (D) OS.
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case_images: The fundus could not be viewed clearly, but small patches of yellow-white lesions could be faintly seen (Figure 1A and B). Fundus fluorescein angiography revealed retinal venous engorgement with fluorescein leakage and hyperfluorescence on the optic disc (Figure 1C and D).
case_images: Histological and immunohistochemical staining of the tumor cells. (A and B) Monomorphic medium-sized lymphoid cells with angiocentric pattern (hematoxylin and eosin stain; original magnification x100 [A] and x200 [B]); Immunostaining for CD3 (C), CD56 (D), granzyme B (E), and EBER by in situ hybridization (F) (original magnifications x100).
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case_images: Biopsies of the skin and subcutaneous nodules were also performed, and the histopathological findings and immunohistochemical staining were consistent with those of ENKTL (Figure 2).
case_images: Positron emission tomography/computed tomography shows significant 18F-FDG uptake in multiple sites of the body (A), including the nasopharynx (B), skin and subcutaneous tissue of the right chest (C), small intestine, and kidneys (D).
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case_images: Positron emission tomography-computed tomography showed significant 18F-fluorodeoxyglucose uptake in the skin, nasopharynx, small intestine, and kidneys (Figure 3).