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case_images: (A-C) The patient developed multiple purpuras on his extremities. (D) CT revealed intestinal edema and ascites. (E) The purpura improved immediately after glucocorticoid treatment.
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case_images: However, he developed multiple purpuras on his extremities and joint swelling on his fingers ( Figures 1A-C ). CT revealed intestinal edema and ascites ( Figure 1D ). After the treatment initiation, the symptoms immediately resolved and creatinine levels improved ( Figures 1E ,  2 ).
case_images: Clinical course of the patient and transition of creatinine levels after four cycles of carboplatin + nab-paclitaxel + pembrolizumab treatment, and diagnosed with irAE IgA vasculitis. Abbreviations: Cre, creatinine; CBDCA, carboplatin; nab-PTX, nab-paclitaxel; Pembro, pembrolizumab; AMPC/CVA, amoxicillin-clavulanate; ABPC/SBT, ampicillin-sulbactam; CTRX, ceftriaxone; mPSL, methylprednisolone; PSL, prednisolone.
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case_images: Laboratory analysis showed elevated white blood cells (11300/microL), CRP (17.66 mg/dL), blood urea nitrogen (30.3 mg/dL), and creatinine (3.35 mg/dL) levels as well as proteinuria and hematuria ( Figure 2 ). After the treatment initiation, the symptoms immediately resolved and creatinine levels improved ( Figures 1E ,  2 ).
case_images: Skin biopsy findings on the lower leg. (A, B) Hematoxylin and eosin staining showed neutrophil-dominated inflammatory cell infiltration from the small vessel walls into the surrounding tissues (scale bar [A] = 400 microm, [B] = 90 microm). (C) Immunofluorescence staining revealed granular IgA deposition in the vessel walls (x200). (D) Immunofluorescence staining revealed granular C3 deposition in the vessel walls (x200).
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case_images: A skin biopsy specimen exhibited neutrophil-dominated inflammatory cell infiltration from the small vessel walls into the surrounding tissues, suggestive of leukocytoclastic vasculitis ( Figures 3A, B ). Immunofluorescence staining showed granular IgA and C3 deposition in the vessel walls ( Figures 3C, D ).