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case_images: Ultrasound and PET-CT imaging revealed anatomical localization and metabolic activity. (A, E) Gynecologic ultrasound reveals an irregularly shaped, Multinodular cervical mass lesion measuring approximately 7.9 cmx6.8 cmx5.7 cm with partially indistinct boundaries, suggestive of confluence of multiple nodules. (B-D, F-H) PET-CT imaging demonstrates cervical soft tissue mass with necrosis, involvement of the uterine corpus and vagina, indistinct boundaries with bladder and rectum, and increased metabolic activity (SUVmax 16.8) in the Case of G-EAC.
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case_images: The lesion demonstrated an irregular, lobulated shape with indistinct boundaries in certain areas, suggesting the presence of multiple nodules merging together ( Figures 1A, E ). PET-CT revealed a soft tissue density mass with necrosis in the uterine cervix invading the uterine body upward and invading the vagina downward, with indistinct demarcation between the bladder and rectum at some level and increased metabolism and a SUVmax of 16.8; also revealed were multiple enlarged lymph nodes in the retroperitoneal inferior vena cava parietal and bilateral iliac vessel travel areas; cervical cancer with metastasis to the above lymph nodes and invasion of the uterine body, vagina, adjacent bladder, and rectum was apparent ( Figures 1B-D, F-H ).
case_images: Histopathological findings in the patient of G-EAC. (A) H&E staining demonstrates the histological features of G-EAC (400X). The tumor cells exhibit irregular glandular structures, invasive growth pattern, and cytoplasmic features characterized by transparency and a foamy appearance. The nuclei display irregular distribution along the basal portion of the glands. (B-D) IHC staining of the primary tumor cells showed that Ki-67, MUC6 and PAX8 were positive expression (400X). (E) P53 mutations were observed in the case.
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case_images: The cytoplasm exhibited distinctive features, characterized by a transparent and foamy appearance ( Figure 2A ). The results showed that Ki-67, MUC6, and PAX8 were positive, while p53 was evaluated as a "wild type" in the case ( Figures 2B-E ).
case_images: Follow-up pelvic MRI and tumor marker results in the patient with G-EAC. (A-C) The patient exhibited a substantial reduction in lesion size on MRI following radiotherapy and chemotherapy. The maximum cross-sectional dimension was measured to be approximately 1.3 cmx2.0 cm. (E-G) Regular pelvic MRI follow-up examinations revealed no signs of tumor recurrence in the postoperative period for this patient. (D) Prominent reduction in CA125 levels observed in the patient's blood after commencement of chemotherapy, demonstrating sustained lower levels throughout subsequent follow-up period. (H) CA19-9 and CEA levels fluctuated within the normal range, accompanied by a remarkable decrease in CA19-9 subsequent to radiotherapy and chemotherapy.
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case_images: The maximum cross-sectional dimension was measured to be approximately 1.3 cm x 2.0 cm ( Figures 3A-C ). Regular pelvic MRI follow-up examinations revealed no signs of tumor recurrence in the postoperative period for this patient ( Figures 3E-G ). Figure 3D ). Furthermore, carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) levels exhibited fluctuations within the normal range, accompanied by a noteworthy decrease in CA19-9 subsequent to the administration of radiotherapy and chemotherapy ( Figure 3H ).