case_images: PMC8214888_01
case_images: Photomicrograph of the biopsy showed: A - biphasic tumor comprising of fibrous as well epithelial component (H&E,10X); B - epithelial component disposed mainly in a glandular pattern along with cords (H&E,20X); C - shows an area of fibrous component (H&E,20X); D - Higher magnification shows round to oval epithelial cells with bland nuclear features and mild to moderate cytoplasm, No pleomorphism (H&E,40X).
case_images: autopsy-11-e2021276-gf01.jpg
case_images: PMC8214888_01_autopsy-11-e2021276-gf01.jpg
case_images: gf01
case_images: The biopsy histomorphology showed a biphasic tumor comprising fibrous stroma with cords and glandular pattern of epithelial cells exhibiting a central discohesion (Figures 1A, 1B). Some areas show fibrous components (Figure 1C). The high-power examination showed round to oval epithelial cells with bland nuclear features and mild to moderate cytoplasm, and no pleomorphism (Figure 1D).
case_images: Photomicrographs of the IHC study on the biopsy specimen. A - CK positive; B - Mib proliferation index 20-30%; C - SMA - negative; D - S100 equivocal. (all pictures 40X).
case_images: autopsy-11-e2021276-gf02.jpg
case_images: PMC8214888_01_autopsy-11-e2021276-gf02.jpg
case_images: gf02
case_images: CK positivity, MIB proliferation index (KI 67) 20-30%, SMA-negative, S100-equivocal (Figures 2A, 2B, 2C, and 2D). CD34 was negative.
case_images: CT study of right leg: A - Sagittal sections reveal multiple patchy cortical erosions/irregularities in the right tibia centered in the diaphysis and contiguously involving the adjacent upper metaphysis. Note adjoining soft tissue thickenings. Streak artifacts are noted due to postoperative changes (Screws); B - MRI Sagittal section of right leg reveals cortical erosions/irregular outlines of the tibia with altered signals in the adjoining bone marrow and soft tissue. Susceptibility artifacts are noted due to postoperative metallic screws.
case_images: autopsy-11-e2021276-gf03.jpg
case_images: PMC8214888_01_autopsy-11-e2021276-gf03.jpg
case_images: gf03
case_images: Streak artifacts are noted due to postoperative changes (screws) (Figure 3A). Susceptibility artifacts are noted due to postoperative metallic screws (Figure 3B).