case_images: PMC7512088_01
case_images: Overview of clinical history and management.
case_images: CRIONM2020-5315178.001.jpg
case_images: PMC7512088_01_CRIONM2020-5315178.001.jpg
case_images: fig1
case_images: An overview of her clinical history and management is given in Figure 1.
case_images: Abdominal CT scan with right renal mass (white arrowheads) and liver metastases (white arrows). (a) Coronal section. (b) Transverse section.
case_images: CRIONM2020-5315178.002.jpg
case_images: PMC7512088_01_CRIONM2020-5315178.002.jpg
case_images: fig2
case_images: She recently presented with a right renal mass, incidentally identified during computerized tomography (CT) scan performed as part of her follow-up (Figure 2).
case_images: Metastatic infiltrating lobular breast carcinoma involving ccRCC. (a) At 40X, the encircled metastatic breast carcinoma focus is surrounded by ccRCC. (b) At 200X, intracytoplasmic mucin is apparent.
case_images: CRIONM2020-5315178.003.jpg
case_images: PMC7512088_01_CRIONM2020-5315178.003.jpg
case_images: fig3
case_images: Microscopic examination of the biopsy specimen revealed two distinct neoplasms (Figure 3).
case_images: A panel of immunohistochemical stains performed supports the morphologic impression of two distinct neoplasms:ccRCC and metastatic lobular breast carcinoma. The neoplastic cells of the ccRCC are negative for GATA3 and ER, but immunoreactive for ECAD and PAX-8. The neoplastic cells of the metastatic lobular breast carcinoma are immunoreactive for GATA3 and ER, but negative for ECAD and PAX-8. Immunostains for CK7, CD10, and RCC antigen are not shown.
case_images: CRIONM2020-5315178.004.jpg
case_images: PMC7512088_01_CRIONM2020-5315178.004.jpg
case_images: fig4
case_images: The stains performed included: cytokeratin 7 (CK7), GATA3, estrogen receptor (ER), e-cadherin (ECAD), PAX-8, CD10, and renal cell carcinoma antigen (RCC) (see Figure 4).