case_images: PMC11007090_01
case_images: HE slides showing loose lamina propria strome within the ileocecal mucosa, evenly distributed powdery stained cells, and inflammatory eosinophil cell infiltration (Magnification x400). IHC staining showing positive expression to CD1a in atypical cells (Magnification x100).
case_images: pore-30-1611705-g001.jpg
case_images: PMC11007090_01_pore-30-1611705-g001.jpg
case_images: F1
case_images: However, the IHC results for the CD30, ALK, CD117, CKpan, and CD138 tumor markers were negative (Figure 1).
case_images: Fluorescence polymerase chain reaction amplification plot showing a BRAF gene mutation of the p.V600E type.The X-axis represents the cycle time (ct), and the Y-axis represents the fluorescence intensity.FAM and VIN are two fluorescent labels. A patient is deemed to have the BRAF p.V600E mutation if the amplification curve of the FAM signal is S-shaped and the mutation ct value is above 26.
case_images: pore-30-1611705-g002.jpg
case_images: PMC11007090_01_pore-30-1611705-g002.jpg
case_images: F2
case_images: The BRAF p.V600E gene mutation was detected by fluorescence Polymerase Chain Reaction (PCR) using the Amplification Refractory Mutation System (ARMS) method (Figure 2).