case_images: PMC11239378_01
case_images: Liver CT scan: A single mass in the liver as observed by CT imaging (arrow). The Lesion exhibited slightly low-density on plain CT scan (A), Mild enhancement was observed in the arterial phase (B), Contrast washout observed in the portal phase (C) and delayed phase (D).
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case_images: The CT attenuation value of the mass ranged from 46-50 HU ( Figure 1A ). The CT attenuation value of the enhanced scan of the hepatic artery phase ranged from 75-86 HU ( Figure 1B ). In the hepatic portal vein phase scan, the CT attenuation value ranged from 72-81 HU ( Figure 1C ), whereas that of the delayed phase was approximately 66-78 HU ( Figure 1D ).
case_images: Morphologic and immunohistochemical features of RDD observed in the liver mass. Liver tissue (*) and diseased tissue (#) with high number of lymphocytes. (A) H&E staining image of large histiocytes distributed in the space between lymphoid follicles (x1 magnification), lymphocytes are observed in the cytoplasm of some large histiocytes (Emperipolesis) (indicated by the arrow). (B) H&E staining showing expression of CD68 (C) and S100 (x800 magnification), (D) Expression of CD68 (C) and S100 in the histiocytes as determined by IHC (x400 magnification).
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case_images: Figure 2A ). Furthermore, several large histiocytes with pale cytoplasm and oval nucleoli were observed in the interstitial zone of the follicles. Lymphocytes were observed in the cytoplasm of some large histiocytes, a phenomenon known as Emperipolesis ( Figure 2B ). Immunohistochemical analysis revealed positive expression of CD68, CD163, and S100, and negative expression of CD1a and OCT2 in the large histiocytes ( Figures 2C, D ).