case_images: PMC3678198_01
case_images: Multi-cavitary ciliary body melanoma in a 66-year-old Caucasian female. (a) Slit lamp photograph of the right eye showing temporal iris bulge suggestive of ciliary body mass. (b) Ultrasound biomicroscopy revealed a 4 mm thick ciliary body mass with solid tumor posteriorly as well as multiple acoustically empty cavities. (c) Gross pathology showed empty and sparse proteinaceous fluid-filled cavities following partial lamellar scleroiridocyclectomy. Scleral base is still attached. (d) Histopathology showed solid mass in the base and large cavities in the apex (H and E, x15). (e) Composed of low-grade amelanotic spindle-shaped melanoma cells (H and E, x20). (f) The tumor cells showed positive staining with melanoma marker microphthalmia transcription factor-2. Note that the empty cavities are lined by tumor cells and not epithelial cells (H and E, x20)
case_images: OJO-6-48-g001.jpg
case_images: PMC3678198_01_OJO-6-48-g001.jpg
case_images: F1
case_images: Slit lamp evaluation of the right eye revealed anterior bulging of the iris temporally at 9:00 [Figure 1a]. Large areas of acoustically empty cavities were present and lined tissue walls measured 100-500 mum [Figure 1b]. Grossly, the sectioned tumor showed an irregular pigmented mass with numerous irregular cystic cavities [Figure 1c]. Histopathology disclosed a ciliary body tumor composed of low-grade amelanotic spindle-shaped melanoma cells with round or oval nuclei and containing finely dispersed chromatin [Figure 1d and e]. Immunohistochemistry with melanoma markers indicated positivity with microphthalmia transcription factor-2, confirming the diagnosis of low-grade spindle melanoma of the ciliary body [Figure 1f].