case_images: PMC2823760_01
case_images: PMC2823760_02
case_images: PMC2823760_03
case_images: PMC2823760_04
case_images: Case 4. The lesions are large and pedunculated protruding 2 cm and 6 cm, respectively, from the nipple-areolar complexes.
case_images: 1752-1947-4-22-1.jpg
case_images: PMC2823760_04_1752-1947-4-22-1.jpg
case_images: F1
case_images: The lesions were large and pedunculated, and extended outward 2 cm and 6 cm respectively from the areolar region (Figure 1).
case_images: PMC2823760_05
case_images: PMC2823760_06
case_images: Case 6. The lesions deforming both nipples and areolar regions.
case_images: 1752-1947-4-22-2.jpg
case_images: PMC2823760_06_1752-1947-4-22-2.jpg
case_images: F2
case_images: The lesions were painful and extended outward at least 7 cm to 8 cm from the nipple and areola, thus deforming both nipples (Figure 2).
case_images: PMC2823760_07
case_images: PMC2823760_08
case_images: PMC2823760_09
case_images: Case 9. The extensive congenital plexiform neurofibroma involved the outer quadrants of her right breast and extends to the nipple-areolar complex and to the homolateral axillary region and arm.
case_images: 1752-1947-4-22-3.jpg
case_images: PMC2823760_09_1752-1947-4-22-3.jpg
case_images: F3
case_images: An inspection of her skin revealed extensive congenital plexiform neurofibroma in the outer quadrants of her right breast that extended to the nipple-areolar complex and to the homolateral axillary region and arm (Figure 3).
case_images: Case 4. The neurofibroma is composed of widely spaced cells with elongated nuclei and scant cytoplasm and embedded in mucopolysaccaride-rich, variably collagenous matrix (hematoxylin and eosin staining, original magnification (A) x125, and (B) x250).
case_images: 1752-1947-4-22-4.jpg
case_images: PMC2823760_09_1752-1947-4-22-4.jpg
case_images: F4
case_images: In particular, the 4th and 6th patients had neurofibromas that were composed of widely spaced cells devoid with elongated nuclei and scant cytoplasm and embedded in matrices that were rich in mucopolysaccharide and variably collagenous (Figures 4a and 4b).
case_images: Case 9. The cell formations resemble Wagner-Meissner corpuscles. These are spherical and aggregated (haematoxylin and eosin staining; original magnification x640).
case_images: 1752-1947-4-22-5.jpg
case_images: PMC2823760_09_1752-1947-4-22-5.jpg
case_images: F5
case_images: Tactile differentiation was apparent, and the pseudomeissnerian corpuscles were found to be spherical and aggregated (Figure 5).