case_images: PMC10462392_01
case_images: Histopathological and gross cardiac findings associated with acute parvoviral myocarditis and post-myocarditis DCM phenotype. (A) Puppy A9. Intranuclear viral inclusion bodies (black arrowheads) are located in cardiomyocytes. The adjacent interstitium is expanded by low numbers of fibroblasts, lymphocytes, and plasma cells. Hematoxylin and eosin stain. 400x magnification. (B) Puppy, A8, heart. The left ventricle is pale (denoted by white arrows). Pallor extends over the region of the interventricular septum to the right ventricle.
case_images: fvets-10-1229756-g0002.jpg
case_images: PMC10462392_01_fvets-10-1229756-g0002.jpg
case_images: F2
case_images: Histopathology showed infection of cardiomyocytes with viral inclusion bodies with low numbers of lymphocytes and plasma cells signifying infection of cardiomyocytes with parvovirus and the inflammatory response to viral infection (Figure 2).
case_images: Transthoracic echocardiogram and electrocardiogram findings for puppy A4. Right parasternal short axis view at the level of the left ventricular papillary muscles (A) at 11 weeks old with a hyperechoic region in the posterior papillary muscle (white arrow) and on the endocardial surface of the interventricular septum (white arrow head). (B) Repeat of puppy A4 echocardiogram at 1.5 years of age. The hyperechoic regions (white arrow and white arrow head) have resolved. (C) Normal electrocardiography results for puppy A4 at 11 weeks. Puppies A1-3 and puppies 5-7 all had normal electrocardiograms consistent with the tracing presented for puppy A4.
case_images: fvets-10-1229756-g0003.jpg
case_images: PMC10462392_01_fvets-10-1229756-g0003.jpg
case_images: F3
case_images: In this case report, puppy A4 and puppy A6 both had hyperechoic areas of the left ventricle that may have indicated ischemia on their initial echocardiograms at 11 weeks (Figure 3). The seven puppies evaluated in this study did not demonstrate any of the ECG abnormalities described above (Figure 3).