case_images: PMC7128049_01
case_images: Stains of primary urethral tumor seen at 200x magnification. (a) Urethral squamous cell carcinoma hematoxylin and eosin stain. (b) Urethral squamous cell carcinoma with negative uroplakin stain. (c) Urethral squamous cell carcinoma with positive CK5/6 stain. (d) Urethral squamous cell carcinoma with positive p16 stain.
case_images: CRIONM2020-6349456.001.jpg
case_images: PMC7128049_01_CRIONM2020-6349456.001.jpg
case_images: fig1
case_images: A cystoscopy noted a 7 mm ventral urethral lesion. A partial urethrectomy showed a squamous cell carcinoma of the penile urethra which was uroplakin-negative, CK5/6-positive, and p16-positive with carcinoma in situ in other areas (Figure 1).
case_images: Magnetic resonance imaging of the brain showing progression of leptomeningeal disease. (a) Hyperintensity can be seen in L parasagittal sinus in this T2 Flair at time of diagnosis of LMD. (b) Increased hyperintensity in the same region in this T2 Flair taken 4 months after diagnosis of LMD.
case_images: CRIONM2020-6349456.002.jpg
case_images: PMC7128049_01_CRIONM2020-6349456.002.jpg
case_images: fig2
case_images: L superior parietal lobule" (Figure 2). Leptomeningeal disease was suspected, and MRIs of spine and lumbar puncture were pursued. While he demonstrated an initial clinical response, repeat MRI brain obtained 4 months after diagnosis showed progression of leptomeningeal disease (Figure 2).