case_images: PMC5070041_01
case_images: Large mass in the right lobe of the thyroid displacing the trachea medially, common carotid artery posteriorly, and sternocleidomastoid muscle laterally
case_images: CJ-13-23-g001.jpg
case_images: PMC5070041_01_CJ-13-23-g001.jpg
case_images: F1
case_images: The lesion had heterogeneous contrast enhancement with lobulated contour, and internal macrocalcifications with necrotic areas were obvious [Figure 1].
case_images: Hypercellular smear with prominent single cells, insular pattern, and transgressing vessels (Diff-Quik, x40)
case_images: CJ-13-23-g002.jpg
case_images: PMC5070041_01_CJ-13-23-g002.jpg
case_images: F2
case_images: The FNA was hypercellular not only as single cells but also insular and trabecular arrangements were noticed [Figures 2 and 3].
case_images: Cells have delicate eosinophilic cytoplasm (Pap, x400)
case_images: CJ-13-23-g003.jpg
case_images: PMC5070041_01_CJ-13-23-g003.jpg
case_images: F3
case_images: The FNA was hypercellular not only as single cells but also insular and trabecular arrangements were noticed [Figures 2 and 3].
case_images: Cells have a high nuclear/cytoplasmic ratio, nuclei are round, slightly hyperchromatic and relatively uniform with macronucleoli (Pap, x400)
case_images: CJ-13-23-g004.jpg
case_images: PMC5070041_01_CJ-13-23-g004.jpg
case_images: F4
case_images: Nuclei were round, slightly hyperchromatic, and macronucleoli were prominent [Figure 4].
case_images: Cell block (H and E, x40)
case_images: CJ-13-23-g005.jpg
case_images: PMC5070041_01_CJ-13-23-g005.jpg
case_images: F5
case_images: Immunohistochemical analyses were performed on the cell-block [Figure 5].
case_images: Diffuse nuclear TTF-1 positivity (x40)
case_images: CJ-13-23-g006.jpg
case_images: PMC5070041_01_CJ-13-23-g006.jpg
case_images: F6
case_images: PAX-8 revealed diffuse nuclear positivity, whereas p53 was positive in 9.2% of cell nuclei [Figures 6 and 7]. Pan-CK showed extensive and thyroglobulin (TG) weak focal cytoplasmic staining.
case_images: Nuclear p53 positivity (x40)
case_images: CJ-13-23-g007.jpg
case_images: PMC5070041_01_CJ-13-23-g007.jpg
case_images: F7
case_images: PAX-8 revealed diffuse nuclear positivity, whereas p53 was positive in 9.2% of cell nuclei [Figures 6 and 7]. Pan-CK showed extensive and thyroglobulin (TG) weak focal cytoplasmic staining.