case_images: PMC11247704_01
case_images: Changes in the patient's lactate levels, MAP, and CAI. CAI, catecholamine index; MAP, mean arterial pressure. After the administration of methylene blue, there was an immediate increase in the patient's blood pressure, and her catecholamine index also showed a decreasing trend. In addition, the patient's lactate levels, which were initially unmeasurable, became measurable and demonstrated a decreasing trend over time.
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case_images: In addition, her lactate levels became measurable and began to decrease over time (Figure 1).
case_images: Changes in the metformin concentrations of blood and CHDF waste liquid. CHDF, continuous hemodiafiltration. The temporal changes in the metformin concentrations of blood and the waste dialysate fluid are presented. The blood concentration consistently showed a decreasing trend, and there was no significant difference between the metformin concentrations of blood and waste dialysate fluid, suggesting efficient removal of the drug through dialysis. On the contrary, the blood concentration of metformin had significantly decreased by the time methylene blue was administered.
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case_images: These measurements showed that her blood concentration of metformin immediately on arrival was 130 mcg/mL, and the approximate half-life of the drug was 5-9 h (Figure 2).