case_images: PMC10838197_01
case_images: A large 19 mm nodule in the right upper lobe lung on noncontrast CT chest.
case_images: CRIPU2024-1315222.001.jpg
case_images: PMC10838197_01_CRIPU2024-1315222.001.jpg
case_images: fig1
case_images: The CT chest scan performed at that time showed no acute infiltrate or pulmonary embolism but revealed emphysema and a right upper lobe lung nodule (Figure 1).
case_images: PMC10838197_02
case_images: Eosinophils and epithelioid histiocyte-like cell infiltration mixed with fragments of blood clots (arrow-cleaved Langerhans cell nuclei).
case_images: CRIPU2024-1315222.002.jpg
case_images: PMC10838197_02_CRIPU2024-1315222.002.jpg
case_images: fig2
case_images: Pathology showed marked inflammatory infiltrate with abundant eosinophils and epithelioid histiocyte-like cells suggestive of Langerhans cell histiocytosis (Figure 2).
case_images: Diffuse immune reactivity against CD1a and Langerhans cells.
case_images: CRIPU2024-1315222.003.jpg
case_images: PMC10838197_02_CRIPU2024-1315222.003.jpg
case_images: fig3
case_images: In addition, antibodies against CD1a and Langerhans showed diffuse reactivity within histiocytic infiltrate, which confirmed the diagnosis of pulmonary LCH (Figure 3).
case_images: PMC10838197_03