case_images: PMC8144523_01
case_images: Occupation in the right inferior lobe of lung. (A) lung window, (B) mediastinal window.
case_images: fonc-11-639168-g001.jpg
case_images: PMC8144523_01_fonc-11-639168-g001.jpg
case_images: f1
case_images: A contrast-enhanced CT scan of the chest and abdomen showed a soft mass (42 x 38 mm) in the inferior lobe of the right lung without any lymph nodes or distant metastasis ( Figure 1 ).
case_images: Photomicrograph showing the cytomorphological finds (A) H&E x10; a H&E x100) and immunohistochemical staining of the malignancy, positive for Ki-67 (B) IHC x10; b IHC x100), EMA (C) IHC x10; c IHC x100), CK8/18 (D) IHC x10; d IHC x100), TTF-1 (E) IHC x10; e IHC x100), CD34 (F) IHC x10; f IHC x100), CD31 (G) IHC x10; g IHC x100), and SMA (H) IHC x10; h IHC x100).
case_images: fonc-11-639168-g002.jpg
case_images: PMC8144523_01_fonc-11-639168-g002.jpg
case_images: f2
case_images: NapsinA(-), CK5/6(-), P40(-), P63(-), S-100(-), ERG(-), and Desmin(-) ( Figure 2 ).
case_images: A reexamination CT scan one month after surgery showed new soft tissue nodules in the mediastinum.
case_images: fonc-11-639168-g003.jpg
case_images: PMC8144523_01_fonc-11-639168-g003.jpg
case_images: f3
case_images: Unfortunately, follow-up CT reexamination one month after surgery demonstrated disease recurrence in the mediastinum and right pleural effusion ( Figure 3 ).
case_images: Reexamination PET-CT scan showing CR after six cycles of second-line treatment.
case_images: fonc-11-639168-g005.jpg
case_images: PMC8144523_01_fonc-11-639168-g005.jpg
case_images: f5
case_images: PR ( Figure 4 -A3, B3, C3, D3). PET-CT was performed for therapeutic response assessment, and the results showed CR after the completion of six cycles of treatment ( Figure 5 ).