case_images: PMC6196674_01
case_images: Family pedigree demonstrating affected individuals and consanguinity, favoring autosomal recessive inheritance
case_images: SJMMS-6-36-g001.jpg
case_images: PMC6196674_01_SJMMS-6-36-g001.jpg
case_images: F1
case_images: His parents are consanguineous with generations of consanguinity reported in their respective families [Figure 1].
case_images: Compact hyperkeratotic plaques and thick scales affecting the soles
case_images: SJMMS-6-36-g002.jpg
case_images: PMC6196674_01_SJMMS-6-36-g002.jpg
case_images: F2
case_images: Soles and palms showed hyperkeratotic plaques [Figure 2].
case_images: Scattered thick scales with ridging over the palms and flexor aspect of the upper limb
case_images: SJMMS-6-36-g003.jpg
case_images: PMC6196674_01_SJMMS-6-36-g003.jpg
case_images: F3
case_images: The upper and lower extremities had thick scales with ridging, especially over the flexors [Figures 3 and 4].
case_images: Scattered thick scales with ridging over the dorsal aspect of the feet and lower extremities
case_images: SJMMS-6-36-g004.jpg
case_images: PMC6196674_01_SJMMS-6-36-g004.jpg
case_images: F4
case_images: The upper and lower extremities had thick scales with ridging, especially over the flexors [Figures 3 and 4].
case_images: Erythematous patches and scattered scales over the trunk
case_images: SJMMS-6-36-g005.jpg
case_images: PMC6196674_01_SJMMS-6-36-g005.jpg
case_images: F5
case_images: The trunk was also affected with scattered thick scales [Figure 5].
case_images: Prominent hyperkeratosis with irregular acanthosis and vacuolar degeneration of the granular and spinous layers (a and b); occasional keratohyalin bodies with minimal blistering overlying chronic inflammatory infiltrate (c); hematoxylin and eosin stain, original magnification (a and b) x10: (c) x40
case_images: SJMMS-6-36-g006.jpg
case_images: PMC6196674_01_SJMMS-6-36-g006.jpg
case_images: F6
case_images: In addition, there were occasional keratohyalin bodies and minimal blistering with an overlying mild perivascular chronic inflammatory infiltrate [Figure 6].