case_images: PMC5751031_01
case_images: Centrizonal parenchyma demonstrating severe cholestasis with formation of cholestatic rosettes, mild lymphocytic inflammation, reactive changes in hepatocytes, and an acidophil body (apoptotic hepatocyte). Hematoxylin and eosin stain, 400x overall magnification.
case_images: omx077f01.jpg
case_images: PMC5751031_01_omx077f01.jpg
case_images: omx077F1
case_images: A percutaneous liver biopsy was performed showing severe cholestasis with bile duct injury/inflammation and hepatocyte injury without steatosis (Fig. 1), consistent with DILI.