case_images: PMC6754894_01
case_images: Invasive ductal carcinoma (H&E).
case_images: CRIONM2019-6460847.001.jpg
case_images: PMC6754894_01_CRIONM2019-6460847.001.jpg
case_images: fig1
case_images: The histopathology exam showed proliferation of epithelial cells of the mammary canals infiltrating to the space between the canals (Figure 1) and in addition to simultaneous ductal carcinoma in situ (Figure 2).
case_images: Magnified image showing ductal carcinoma in situ.
case_images: CRIONM2019-6460847.002.jpg
case_images: PMC6754894_01_CRIONM2019-6460847.002.jpg
case_images: fig2
case_images: The histopathology exam showed proliferation of epithelial cells of the mammary canals infiltrating to the space between the canals (Figure 1) and in addition to simultaneous ductal carcinoma in situ (Figure 2).
case_images: CK7 staining with positive results indicating carcinoma.
case_images: CRIONM2019-6460847.003.jpg
case_images: PMC6754894_01_CRIONM2019-6460847.003.jpg
case_images: fig3
case_images: CK7 staining proved carcinoma origin (Figure 3).
case_images: H&E microscopic image of the left mass showing spindle-shaped cells.
case_images: CRIONM2019-6460847.004.jpg
case_images: PMC6754894_01_CRIONM2019-6460847.004.jpg
case_images: fig4
case_images: Surprisingly, histopathology of excisional biopsy performed to the left breast mass showed high cellularity of spindle-shaped cells; the mass contained fatty tissue and showed an abundant mitotic activity (Figure 4).
case_images: Negative CK7 stain of the left mass.
case_images: CRIONM2019-6460847.005.jpg
case_images: PMC6754894_01_CRIONM2019-6460847.005.jpg
case_images: fig5
case_images: Immunohistochemistry (IHC) showed negative results for epithelial markers, such as cytokeratin 7 (CK7) (Figure 5) and epithelial membrane antigen (EMA), leukocyte common antigen (LCA), and desmin, which in turn excluded carcinoma origin, lymphoma/leukaemia, and muscular origin, respectively.
case_images: CD10-positive staining for the left mass suggesting stromal origin.
case_images: CRIONM2019-6460847.006.jpg
case_images: PMC6754894_01_CRIONM2019-6460847.006.jpg
case_images: fig6
case_images: Positive staining of CD10 (Figure 6) confirmed stromal origin confirming the diagnosis of high-grade stromal sarcoma of the breast.