case_images: PMC3303532_01
case_images: Clinical photograph showing swelling on the palate
case_images: JOMFP-16-97-g002.jpg
case_images: PMC3303532_01_JOMFP-16-97-g002.jpg
case_images: F1
case_images: Intraoral examination exhibited a firm, exophytic, oval mass with an intact overlying mucosa in the region of the right hard palate measuring 3 x 4.5 cm in size [Figure 1].
case_images: Computed tomography scan of patient
case_images: JOMFP-16-97-g003.jpg
case_images: PMC3303532_01_JOMFP-16-97-g003.jpg
case_images: F2
case_images: CT scan revealed a mass on the right side of the hard palate, with no involvement of the maxillary sinus [Figure 2].
case_images: Photograph of gross excisional tissue
case_images: JOMFP-16-97-g004.jpg
case_images: PMC3303532_01_JOMFP-16-97-g004.jpg
case_images: F3
case_images: An excisional biopsy [Figure 3] was performed under local anesthesia. and a bony crater-like defect was seen on the palatal bone after soft tissue removal.
case_images: (a) The overlying epithelium is seen separated from follicles. The histological picture in this view gives the impression of reactive follicular hyperplasia of the lymphoid tissue (H and E, stain; original magnification, x2.5). (b) High-power view of the follicular pattern gives the impression of a reactive lesion (H and E, stain; original magnification, x10)
case_images: JOMFP-16-97-g005.jpg
case_images: PMC3303532_01_JOMFP-16-97-g005.jpg
case_images: F4
case_images: Histopathological examination of sections of the resected specimen revealed an intact stratified squamous epithelium with underlying vaguely follicular and diffuse proliferation of lymphoid cells [Figure 4a and b].
case_images: Magnified view showing central larger cells with mitotic figures, convoluted nuclei, and inconspicuous nucleoli. Peripherally, small round lymphocytes are seen (H and E, stain; original magnification, x20)
case_images: JOMFP-16-97-g006.jpg
case_images: PMC3303532_01_JOMFP-16-97-g006.jpg
case_images: F5
case_images: The central large cells had abundant pinkish cytoplasm and convoluted nuclei with inconspicuous nucleoli [Figure 5].
case_images: The large lymphoid cells show positive immunoreactivity for CD20, whereas the peripheral small lymphocytes are negative. Inset shows control stain (original magnification, x10)
case_images: JOMFP-16-97-g007.jpg
case_images: PMC3303532_01_JOMFP-16-97-g007.jpg
case_images: F6
case_images: The large lymphoid cells showed immunoreactivity for CD20 and the rim of small lymphocytes were positive for CD5 [Figure 6].
case_images: The peripheral small lymphocytes show positive immunoreactivity for CD5, whereas the central large cells are negative. Inset shows control stain (original magnification, x10)
case_images: JOMFP-16-97-g008.jpg
case_images: PMC3303532_01_JOMFP-16-97-g008.jpg
case_images: F7
case_images: The large lymphoid cells were negative for CD5, Bcl-2, and CD10 [Figures 7-9].
case_images: The peripheral small lymphocytes show positive immunoreactivity for Bcl2, whereas the central large cells are negative. Inset shows control stain (original magnification, x10)
case_images: JOMFP-16-97-g009.jpg
case_images: PMC3303532_01_JOMFP-16-97-g009.jpg
case_images: F8
case_images: The large lymphoid cells were negative for CD5, Bcl-2, and CD10 [Figures 7-9].
case_images: Negative immunoreactivity for CD10 (original magnification, x10)
case_images: JOMFP-16-97-g010.jpg
case_images: PMC3303532_01_JOMFP-16-97-g010.jpg
case_images: F9
case_images: The large lymphoid cells were negative for CD5, Bcl-2, and CD10 [Figures 7-9].
case_images: Immunohistochemistry profile showing very low Ki67 proliferative index (original magnification, x20)
case_images: JOMFP-16-97-g011.jpg
case_images: PMC3303532_01_JOMFP-16-97-g011.jpg
case_images: F10
case_images: The Ki67 proliferative index was 1% [Figure 10].