case_images: PMC11764380_01
case_images: Lipoatrophy in the right upper arm after 11 weeks of weekly injections with the non-pegylated LAGH fusion protein formulation. The patient, a 5.5-year-old girl diagnosed with idiopathic short stature and growth retardation, developed lipoatrophy at the injection site due to repeated injections in the same localized area. The right upper arm mid-circumference measured 14 cm, compared to 16 cm in the left upper arm.
case_images: children-12-00058-g001.jpg
case_images: PMC11764380_01_children-12-00058-g001.jpg
case_images: children-12-00058-f001
case_images: After 11 weeks of treatment, the patient developed lipoatrophy at the injection site, with the mid-circumference of the right upper arm measuring 14 cm compared to 16 cm on the left (Figure 1).
case_images: Progression of lipoatrophy in the left upper arm after an additional 8 weeks of using the non-pegylated LAGH fusion protein formulation during follow-up. Despite instructions to switch to daily hGH injections, the parents continued administering the non-pegylated LAGH fusion protein formulation in the left upper arm, resulting in further lipoatrophy. At the 8-week follow-up, the left upper arm mid-circumference had decreased to 14 cm, while the right upper arm showed slight recovery, with a mid-circumference of 14.5 cm.
case_images: children-12-00058-g002.jpg
case_images: PMC11764380_01_children-12-00058-g002.jpg
case_images: children-12-00058-f002
case_images: At the follow-up assessment at age 5.7 years, lipoatrophy recurred, with the mid-circumference of the left upper arm decreasing to 14 cm, while the right upper arm showed partial recovery, increasing to 14.5 cm (Figure 2).