case_images: PMC7573191_01
case_images: Chest radiography showed a cardiothoracic ratio of 66 % with cardiac enlargement and bilateral pleural effusions, which were greater on the right. Lung lesions were not clearly visible.
case_images: EXCLI-19-1161-g-001.jpg
case_images: PMC7573191_01_EXCLI-19-1161-g-001.jpg
case_images: F1
case_images: Chest radiography (Figure 1(Fig. 1)) showed a cardiothoracic ratio of 66 % with cardiac enlargement and bilateral pleural effusions.
case_images: Contrast-enhanced chest computed tomography scan confirmed the ultrasound findings and showed mass effect on the superior vena cava, which was significantly narrowed. The inside of the tumor could not be clearly visualized on contrast-enhanced imaging; neither fatty nor calcified components were observed.
case_images: EXCLI-19-1161-g-002.jpg
case_images: PMC7573191_01_EXCLI-19-1161-g-002.jpg
case_images: F2
case_images: Contrast-enhanced chest Computed tomography (CT) scan (Figure 2(Fig. 2)) confirmed the ultrasound findings and showed mass effect on the superior vena cava, which was significantly narrowed.
case_images: Microscopic examination of hematoxylin and eosin-stained slides of the tumor specimen showed no pattern or any specific tissue architecture at low magnification (A), indicating an undifferentiated malignant tumor. In addition, highly deformed nuclei were found on high magnification (B). Immunostaining was positive for vimentin (C).
case_images: EXCLI-19-1161-g-003.jpg
case_images: PMC7573191_01_EXCLI-19-1161-g-003.jpg
case_images: F3
case_images: Microscopic examination of hematoxylin and eosin-stained slides of the tumor specimen showed no pattern or any specific tissue architecture at low magnification (Figure 3A(Fig. 3)), indicating an undifferentiated malignant tumor. In addition, highly deformed nuclei were found on high magnification (Figure 3B(Fig. 3)). Immunostaining showed positive results for vimentin (Figure 3C(Fig. 3)) and negative results for CD5, CD31, CD34, CD45, CD68, CD138, CK-CAM5.2, CK-AE1/1, AE3, EMA, calretinin, desmin, alpha-SMA, MA-HHF, S100, D2-40, HMB45, EMA, and MelanA.