case_images: PMC11239425_01
case_images: PMC11239425_02
case_images: PMC11239425_03
case_images: PMC11239425_04
case_images: Meal test curves of conjugated and unconjugated bile acids. gCA, glycocholic acid; CA, cholic acid; gDCA, glycodeoxycholic acid; DCA, glycodeoxycholic acid; gCDCA, glycochenodeoxycholic acid; CDCA, chenodeoxycholic acid.
case_images: fped-12-1418963-g001.jpg
case_images: PMC11239425_04_fped-12-1418963-g001.jpg
case_images: F1
case_images: To investigate bile acid (BA) flow, we analyzed postprandial plasma levels after standardized liquid mixed meals (Figures 1, 2). Figure 1 shows the postprandial curves of the plasma glycine-conjugated and unconjugated bile acids. Fasted and postprandial bile acid levels remained comparable during five years of gDCA 3/week treatment (Figures 1, 2).
case_images: Fasting and postprandial composition of plasma conjugated and unconjugated bile acid levels. Pie charts indicate bile acid pool composition in percentage whereas bar charts indicate absolute bile acid pool composition. BA, bile acid; CA, cholic acid (beige); DCA, deoxycholic acid (orange); UDCA, ursodeoxycholic acid (green); CDCA, chenodeoxycholic acid (red).
case_images: fped-12-1418963-g002.jpg
case_images: PMC11239425_04_fped-12-1418963-g002.jpg
case_images: F2
case_images: To investigate bile acid (BA) flow, we analyzed postprandial plasma levels after standardized liquid mixed meals (Figures 1, 2). Figure 2 shows fasted and postprandial plasma bile acid levels expressed as percentage of the pool and as absolute values. Increasing the dose further eventually led to a more or less evenly distributed bile acid composition (Figure 2, upper panel). Starting and increasing the gDCA dose further led to a relative well-distributed postprandial bile acid composition (Figure 2, lower panel). Fasted and postprandial bile acid levels remained comparable during five years of gDCA 3/week treatment (Figures 1, 2).