case_images: PMC7728121_01
case_images: PMC7728121_02
case_images: Human thymus with normal histological structure; next to an artery (a), there is a formation (arrow) with typical appearance of a lamellar (Pacinian) corpuscle (insertion) with the inner core (short arrow), outer core (*) and the external fibrous capsule (open arrow). Hematoxylin-Eosin staining, x25 (inset, x100)
case_images: RJME-61-1-273-fig1.jpg
case_images: PMC7728121_02_RJME-61-1-273-fig1.jpg
case_images: F1
case_images: In the specimen with normal histomorphological structure of a female newborn thymus, a formation of oval shape, with the longest diameter up to 0.5 mm and concentric lamellar composition, was noticed in the interstitium in close relation to blood vessels and identified as a Pacinian lamellar corpuscle (Figure 1).
case_images: Lamellar (Pacinian) corpuscle in the human thymus. The inner and the outer core are S100-positive, the inner core (ic) shows CD56 positivity with synaptophysin-positive centrally-positioned oval-shaped nerve fiber (n.f.), between the inner and the outer core there is a CD34-positive capillary loop. Immunoperoxidase technique, 3,3'-Diaminobenzidine, x400. CD: Cluster of differentiation
case_images: RJME-61-1-273-fig2.jpg
case_images: PMC7728121_02_RJME-61-1-273-fig2.jpg
case_images: F2
case_images: Using immunohistochemical (IHC) methods, we clearly described the main components (Figure 2): (i) synaptophysin-positive nerve fiber was present in the center of the inner core; (ii) neural cell adhesion molecule (CD56)-positive Schwann-like cells attached directly to the nerve fiber, and forming the central portion of the inner core; (iii) multilayered S100 antigen-positive Schwann cells forming the inner core; (iv) CD34-positive endothelial cells of blood capillaries present at the outer surface of the inner core and among connective tissue cells of the outer core.
case_images: PMC7728121_03