case_images: PMC11372402_01
case_images: T1-and T2-weighted transverse (a and c) and coronal (b and d) magnetic resonance imaging (MRI) images of the patient showing bilateral orbital infiltration.
case_images: BEJ-9-155-g001.jpg
case_images: PMC11372402_01_BEJ-9-155-g001.jpg
case_images: F1
case_images: Orbital MRI revealed soft tissue infiltrating the entire extraconal and conal distance, involving the episcleral area around the eyeball, and extending toward both palpebral areas and retrobulbar space in the right orbit (Fig. 1).
case_images: Tumor cells with irregular distribution among collagen bundles (hematoxylin eosin) (a). Immunohistochemical positive staining of E-cadherin (b), GATA-3 (c) and estrogen receptor (d) in tumor cells.
case_images: BEJ-9-155-g002.jpg
case_images: PMC11372402_01_BEJ-9-155-g002.jpg
case_images: F2
case_images: Immunohistochemical examination demonstrated estrogen receptor (ER)-positive breast cancer (Fig. 2).
case_images: PMC11372402_02
case_images: T1-(a) and T2-weighted (b) MR transverse sections of the patient showing hypertrophic left lateral rectus muscle.
case_images: BEJ-9-155-g003.jpg
case_images: PMC11372402_02_BEJ-9-155-g003.jpg
case_images: F3
case_images: Orbital MRI demonstrated a hypertrophic appearance in the left lateral rectus muscle (Fig. 3).
case_images: Necrotic tumor cell group consisting of undifferentiated cells with prominent nucleoli and epithelioid appearance (hematoxylin eosin) (a). Immunohistochemical focal and weak staining of GATA-3 (b), negative staining of estrogen receptor (c), and PR (d) in tumor cells
case_images: BEJ-9-155-g004.jpg
case_images: PMC11372402_02_BEJ-9-155-g004.jpg
case_images: F4
case_images: In immunohistochemical examination, ER, progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu) were found to be negative, similar to the primary tumor, whereas cytokeratin staining was found to be positive (Fig. 4).
case_images: PMC11372402_03
case_images: T1-and T2-weighted transverse (a and c) and coronal (b and d) magnetic resonance imaging images of the patient demonstrating infiltrative soft tissue in the right orbit.
case_images: BEJ-9-155-g005.jpg
case_images: PMC11372402_03_BEJ-9-155-g005.jpg
case_images: F5
case_images: Since the patient had a history of malignancy, an orbital MRI was performed which demonstrated an infiltrative soft-tissue mass diffusely surrounding half of the intra-orbital segment of the optic nerve in the right orbit (Fig. 5).
case_images: Discohesive tumor cells arranged in single files, cords, and single cells (hematoxylin eosin) (a). Immunohistochemical negative staining of E-cadherin (b), positive staining of GATA-3 (c) and estrogen receptor (d) in tumor cells
case_images: BEJ-9-155-g006.jpg
case_images: PMC11372402_03_BEJ-9-155-g006.jpg
case_images: F6
case_images: Immunohistochemical staining revealed ER positivity (Fig. 6).