case_images: PMC11788402_01
case_images: Comparison of hair before and after treatment. (A-C) Before treatment, the patient's hair was thinning. (D-F) 6 months after treatment, a notable improvement in the patient's hair condition was observed.
case_images: fgene-15-1491870-g001.jpg
case_images: PMC11788402_01_fgene-15-1491870-g001.jpg
case_images: F1
case_images: Dermatologic examination showed thinning and fine hair that were easily pulled out, no loss of eyebrows and eyelashes, no abnormalities in toenails and fingernails (Figures 1A-C). The patient's liver and renal function have been monitored by regular follow-ups and the treatment has continued to the present day. The patient has returned to essentially the same level of hair as before the COVID-19 infection after 6 months (Figures 1D-F).
case_images: Sanger sequencing results of the CDSN gene in the patient and his relatives. The mutation c.701C > A is indicated by an arrow. (A) patient has heterozygous mutation in CDSN gene c.701C > A (p.Ser234*). (B) His father's CDSN gene is wild-type. (C-D) H is mother and maternal grandfather carried the same heterozygous mutation in CDSN gene c.701C > A (p.Ser234*).
case_images: fgene-15-1491870-g002.jpg
case_images: PMC11788402_01_fgene-15-1491870-g002.jpg
case_images: F2
case_images: To further confirm this mutation, Sanger sequencing was carried out, and the results showed that the patient, his mother, and maternal grandfather carry the same heterozygous mutation in the CDSN gene, whereas his father and maternal grandmother have the wild-type CDSN gene (Figure 2).