case_images: PMC6370615_01
case_images: EEG demonstrations before quinidine therapy. (A) Interictal EEG before quinidine therapy showed a large number of 3-5 Hz slow waves with middle and high amplitude in the anterior region in background. (B) Multiple-spike-and-slow-waves of 0.5-1 Hz were observed during the sleep period. (C) Slow spike-and-slow-waves of 1.5-2.5 Hz were observed when the patient was awake. (D) Ictal EEG of the tonic seizure showed short-term fast rhythms burst of 16-20 Hz.
case_images: fneur-10-00064-g0001.jpg
case_images: PMC6370615_01_fneur-10-00064-g0001.jpg
case_images: F1
case_images: Slow spike-and-slow-waves of 1.5 to 2.5 Hz were observed during awake time (Figure 1).
case_images: The changes of the seizure frequency and epileptiform discharges along with the changes of quinidine dosages. (A) The patient was given quinidine at a starting dosage of 5 mg/kg/day. The dose slowly increased and maintained at 13.75 mg/kg/day. As the dosage of quinidine increased, the frequency of tonic seizures (the main type of seizures in the patient) gradually reduced from 16 times per month to 4 times per month. (B) The epileptiform discharge of EEG was 1,323 times per 24 h before taking the quinidine. The epileptiform discharge was 512 times per 24 h in the 3rd month, 652 times per 24 h in the 6th month, 598 times per 24 h in the 9th month. With the increase of dosages, the epileptiform discharge showed a significant reduction.
case_images: fneur-10-00064-g0002.jpg
case_images: PMC6370615_01_fneur-10-00064-g0002.jpg
case_images: F2
case_images: The frequency of tonic seizures subsided by 75% (Figure 2A), whereas the frequency of the other types of seizures was not reduced significantly. The epileptiform discharges decreased by 54.80% (Figure 2B).