case_images: PMC9893998_01
case_images: Endoscopic and histologic findings before (January 2011, first diagnosis) and after (September 2011, histologic complete remission [CR]) the first eradication treatment. a-c Before eradication. d-f After successful eradication. a, d Endoscopy. b, e Histology, x200. c, f Histology, x50.
case_images: crg-2022-0017-0001-528309_f1.jpg
case_images: PMC9893998_01_crg-2022-0017-0001-528309_f1.jpg
case_images: F1
case_images: GI endoscopy revealed reddish, uneven regions in the gastric body, suggestive of a superficial or gastritis-type gastric MALT lymphoma. Gastric pathology showed numerous invasions of small lymphocytes and the presence of lymphoepithelial lesions, and MALT lymphoma was confirmed by a pathologist (Fig. 1a-c). In September 2011, the endoscopic finding revealed a whitish, patchy, and scar-like gastric mucosa, which was suggestive of endoscopic remission; histologic diagnosis showed complete remission (CR) according to the Groupe d'Etude des Lymphomes de l'Adult (GELA) grading system (Fig. 1d-f).
case_images: Endoscopic and histologic findings before (February 2013, histologic responding residual disease [rRD]) and after (January 2016, histologic CR) the second eradication treatment of H. pylori reinfection. a, b Before eradication. c, d After successful eradication. a, c Endoscopy. b, d Histology, x100.
case_images: crg-2022-0017-0001-528309_f2.jpg
case_images: PMC9893998_01_crg-2022-0017-0001-528309_f2.jpg
case_images: F2
case_images: In February 2013, the endoscopic finding showed a reddish and uneven gastric mucosa, which was suggestive of the recurrence of MALT lymphoma; pathologic diagnosis revealed responding residual disease (rRD) according to the GELA system (Fig. 2a, b). In January 2016, an endoscopic examination demonstrated a whitish, patchy, flat, and scar-like gastric mucosa (endoscopic remission), and the histologic diagnosis showed CR according to the GELA system (Fig. 2c, d).
case_images: Endoscopic and histologic findings before (January 2017, histologic rRD) and after (April 2022, histologic CR) the third eradication treatment of H. pylori reinfection. a, b Before eradication. c, d After successful eradication. a, c Endoscopy. b, d Histology, x100. rRD, responding residual disease.
case_images: crg-2022-0017-0001-528309_f3.jpg
case_images: PMC9893998_01_crg-2022-0017-0001-528309_f3.jpg
case_images: F3
case_images: However, in January 2017, the endoscopic finding showed a reddish and uneven gastric mucosa, which was suggestive of the re-recurrence of gastric MALT lymphoma, and the histologic diagnosis showed responding residual disease according to the GELA system (Fig. 3a, b). In April 2022, the endoscopic finding revealed a whitish and scar-like gastric mucosa (endoscopic remission), and the histologic diagnosis showed CR according to the GELA system (Fig. 3c, d).