case_images: PMC9037232_01
case_images: Clinical course according to CT scans. (A) Baseline CT scan at diagnosis in October 2019. (B) PR on icotinib in June 2020. (C) Disease progression in October 2020. (D) PR to osimertinib in January 2021. (E) Abdomen and pelvis CT in June 2021 showed that oedema had caused wall thickening of the colon. (F) SD on aumolertinib in November 2021.
case_images: fphar-13-854277-g001.jpg
case_images: PMC9037232_01_fphar-13-854277-g001.jpg
case_images: F1
case_images: Chest CT showed a lesion in the upper lobe of the right lung with enlarged lymph nodes and pleural effusion (Figure 1A). After 8 months of drug therapy, a routine CT follow-up showed that lesion shrinkage was a partial response (PR) to treatment (Figure 1B). CT re-examination showed an enlarged mass (Figure 1C). She achieved PR 3 months after treatment with osimertinib (Figure 1D). CT revealed oedema caused wall thickening of the colon (Figure 1E). Colonoscopy showed diffuse oedema, erythema and bleeding ulcers from the ileocecal area to the sigmoid colon (Figures 2A,B). CT re-evaluation showed stable disease (SD) in November 2021 (Figure 1F).
case_images: Colonoscopy shows oedema, erythema and bleeding ulcers from the ileocecal area to the sigmoid colon. Formation of the pseudomembrane and necrosis were not found. (A) ileocecal area. (B) transverse colon. (C) Pathological examination of the transverse colon. Mucosal ulcers are formed, and lamina propria inflammatory cells are infiltrated. Dilation of small blood vessels and vascular stasis were observed. The lamina propria also showed ischaemic change. (haematoxylin and eosin stain, x100).
case_images: fphar-13-854277-g002.jpg
case_images: PMC9037232_01_fphar-13-854277-g002.jpg
case_images: F2
case_images: CT revealed oedema caused wall thickening of the colon (Figure 1E). Colonoscopy showed diffuse oedema, erythema and bleeding ulcers from the ileocecal area to the sigmoid colon (Figures 2A,B). Ischaemic change was also seen in the lamina propria (Figure 2C).