case_images: PMC9715734_01
case_images: Ulcerated and bleeding colonic mucosa with petechial hemorrhages.
case_images: fped-10-1044007-g001.jpg
case_images: PMC9715734_01_fped-10-1044007-g001.jpg
case_images: F1
case_images: Fragile colonic mucosa with petechial hemorrhages.
case_images: fped-10-1044007-g002.jpg
case_images: PMC9715734_01_fped-10-1044007-g002.jpg
case_images: F2
case_images: Bleeding colonic mucosa.
case_images: fped-10-1044007-g003.jpg
case_images: PMC9715734_01_fped-10-1044007-g003.jpg
case_images: F3
case_images: Histological examination of colonic biopsies: active colitis, with mucosal microerosions.. (asterisks), a moderate inflammatory infiltrate in the lamina propria, including lymphocytes, plasmacells, and neutrophils (arrows), and an associated multifocal cryptitis, defined by the presence of intraepithelial neutrophils in colonic crypts (arrowheads in the box).
case_images: fped-10-1044007-g004.jpg
case_images: PMC9715734_01_fped-10-1044007-g004.jpg
case_images: F4
case_images: Panniculitis of the lower limbs.
case_images: fped-10-1044007-g005.jpg
case_images: PMC9715734_01_fped-10-1044007-g005.jpg
case_images: F5
case_images: On physical examination baby girl presented ulcerative and necrotic lesions associated with painful edema of the limbs (Figures 5-8).
case_images: Panniculitis of the upper limbs.
case_images: fped-10-1044007-g006.jpg
case_images: PMC9715734_01_fped-10-1044007-g006.jpg
case_images: F6
case_images: On physical examination baby girl presented ulcerative and necrotic lesions associated with painful edema of the limbs (Figures 5-8).
case_images: Ulcerative lesion of the hand.
case_images: fped-10-1044007-g007.jpg
case_images: PMC9715734_01_fped-10-1044007-g007.jpg
case_images: F7
case_images: On physical examination baby girl presented ulcerative and necrotic lesions associated with painful edema of the limbs (Figures 5-8).
case_images: Necrotic lesion of the foot.
case_images: fped-10-1044007-g008.jpg
case_images: PMC9715734_01_fped-10-1044007-g008.jpg
case_images: F8
case_images: On physical examination baby girl presented ulcerative and necrotic lesions associated with painful edema of the limbs (Figures 5-8).
case_images: PMC9715734_02
case_images: Family tree.
case_images: fped-10-1044007-g009.jpg
case_images: PMC9715734_02_fped-10-1044007-g009.jpg
case_images: F9
case_images: TNFAIP3. The other family members in the paternal line presented potential clinical conditions of HA20 but could not be screened for mutations (Figure 9).