case_images: PMC11342308_01
case_images: The lymph nodes exhibited infiltration and destruction by highly atypical neoplastic cells, arranged in solid, large-nested, small-nested, and single-cell patterns, accompanied by evident fibrous reaction and focal necrosis (A, B). Tumor cells featured large nuclei of varying sizes, prominent nucleoli, and abundant eosinophilic cytoplasm (C). Note that the cellular atypia observed within the focal region is of a relatively mild nature (D).
case_images: 10.1177_2632010X241276943-fig1.jpg
case_images: PMC11342308_01_10.1177_2632010X241276943-fig1.jpg
case_images: fig1-2632010X241276943
case_images: Note that the cellular atypia observed within the focal region is of a relatively mild nature (Figure 1).
case_images: Immunohistochemical staining of inguinal lymph node metastatic carcinoma for GATA3 (A), CK7 (B), CK5/6 (C), and Ki-67 (D).
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case_images: PMC11342308_01_10.1177_2632010X241276943-fig2.jpg
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case_images: Based on histomorphology and immunohistochemical expression, lymph node metastasis was supported, and suspected from bladder urothelial carcinoma (Figure 2).
case_images: A nodular mass was identified, characterized by significant urothelial nest hyperplasia (A, B). The epithelial nests were small, closely packed, and exhibited mild cell atypia, with rare mitotic count. The stroma contained increased fibrous tissue and vascular proliferation, with no evidence of muscularis propria infiltration (C, D).
case_images: 10.1177_2632010X241276943-fig3.jpg
case_images: PMC11342308_01_10.1177_2632010X241276943-fig3.jpg
case_images: fig3-2632010X241276943
case_images: The stroma contained increased fibrous tissue, with no evidence of muscularis propria infiltration (Figure 3).
case_images: Immunohistochemical staining of bladder tumor for GATA3 (A), CK7 (B), CK5/6 (C), and Ki-67 (D).
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case_images: PMC11342308_01_10.1177_2632010X241276943-fig4.jpg
case_images: fig4-2632010X241276943
case_images: Immunohistochemical staining results indicated positive expression for Ki67 (10%), P53 (90%, strongly), GATA3, CK7, and CK5/6, while CK20, CD56, Syn, and CgA were negative (Figure 4).