case_images: PMC11333131_01
case_images: OCT of Ganglion layer.
case_images: CRIRH2024-2043012.001.jpg
case_images: PMC11333131_01_CRIRH2024-2043012.001.jpg
case_images: fig1
case_images: OCT (ocular coherence testing) was remarkable for reduced RNFL (retinal nerve fibre layer) as seen in Figure 1.
case_images: Microfocus of mononuclear cells in the adventitia around vasa vasorum, composed mainly of small-sized lymphocytes.
case_images: CRIRH2024-2043012.002.jpg
case_images: PMC11333131_01_CRIRH2024-2043012.002.jpg
case_images: fig2
case_images: Temporal artery biopsy performed on previous admission showed changes consistent with GCA including mural lymphohistiocytic inflammation, mostly adventitia based, with focal involvement of the outer muscle layer and its elastic lamina, while largely sparing the intima, media, and internal elastic lamina, but without giant cells (Figure 2).
case_images: Flow cytometry. Temporal artery (TA), hematoxylin and eosin (H & E), ocular coherence test (OCT), P1-lymphocytes, P2-monocytes, P3-granulocytes, P7-plasma cells.
case_images: CRIRH2024-2043012.003.jpg
case_images: PMC11333131_01_CRIRH2024-2043012.003.jpg
case_images: fig3
case_images: It confirmed the diagnosis of WM, with flow cytometry identifying 2% aberrant B cells with a phenotype suggestive of lymphoplasmacytic lymphoma (Figure 3).
case_images: Microfocus showing most lymphocytes are CD20-positive B cells, with rare CD3-positive T cells.
case_images: CRIRH2024-2043012.004.jpg
case_images: PMC11333131_01_CRIRH2024-2043012.004.jpg
case_images: fig4
case_images: These demonstrated a mononuclear cell infiltrate composed of small numbers of scattered small-sized lymphoid cells (positive for CD20 and kappa light chain, Figure 4) and rare histiocytes (positive for CD68, Figure 5) without forming a solid mass lesion.
case_images: Lymphocytes in this microfocus are negative for CD10 and CD68. There is small numbers of histiocytes (CD68+) in adventitia.
case_images: CRIRH2024-2043012.005.jpg
case_images: PMC11333131_01_CRIRH2024-2043012.005.jpg
case_images: fig5
case_images: These demonstrated a mononuclear cell infiltrate composed of small numbers of scattered small-sized lymphoid cells (positive for CD20 and kappa light chain, Figure 4) and rare histiocytes (positive for CD68, Figure 5) without forming a solid mass lesion.