case_images: PMC10822982_01
case_images: Patient's MRI imaging and comparison with a control subject: T1-weighted MRI image in the coronal (A, B) and in the sagittal (C, D) plane demonstrated the presence of the corpus callosum (A-C) in a control subject and the corpus callosum agenesis (B-D) in our patient, indicated with white arrow. In D an arrowhead indicates a hyperintense lesion on the left frontal lobe consistent with intracranial teratoma. CCA: corpus callosum agenesis. Of note, the control subject is a female patient that performed MRI as follow-up radiological evaluation in the context of a clinical history of non-functioning pituitary adenoma, which underwent successful transsphenoidal neurosurgery.
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case_images: Her medical history showed corpus callosum agenesis and frontal teratoma in neuroradiological follow-up ( Figure 1 ).
case_images: Furst formula. Adapted from Grant et al..
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case_images: PMC10822982_01_fendo-14-1309657-g002.jpg
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case_images: Afterwards, we used the Furst formula ( Figure 2 ), which estimates the electrolyte-free water clearance through the urine/plasma electrolyte ratio, obtaining a value > 1.0, which is indicative of reduced electrolyte-free water clearance.
case_images: Changes in patient serum sodium levels through the observation period, together with the varying daily dosages of tolvaptan: as tolvaptan dose increased, serum sodium levels increased, but it was only with twice-daily tolvaptan administration that serum sodium levels persisted in the normal range. Na: serum sodium.
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case_images: f3