case_images: PMC5468577_01
case_images: Computed tomography (CT) scan of the abdomen and pelvis revealed diffuse thickening of the wall of the urinary bladder with intravesical catheter (red arrows) and brachytherapy radiation seeds in the prostate (yellow arrows).
case_images: CRIONM2017-1853985.001.jpg
case_images: PMC5468577_01_CRIONM2017-1853985.001.jpg
case_images: fig1
case_images: Computed tomography (CT) scan of abdomen and pelvis revealed no evidence of obstructive uropathy, diffuse thickening of the wall of the urinary bladder, and brachytherapy radiation seeds in the prostate (Figure 1).
case_images: Histopathology of the resected bladder lesion. (a) Low-power field H&E stain reveals invasive poorly differentiated carcinoma infiltrates lamina propria and muscularis propria. (b) High-power field H&E stain reveals large polygonal-shape cells with low nuclear to cytoplasmic ratio, coarse chromatin structure, multiple nucleoli, and high rate of mitosis. (c) Immunohistochemical stain positive for chromogranin and (d) negative for PSA.
case_images: CRIONM2017-1853985.002.jpg
case_images: PMC5468577_01_CRIONM2017-1853985.002.jpg
case_images: fig2
case_images: TTF-1 and negative for CK-7, CK-20, PSA, and PAP (Figure 2). This carcinoma was histologically distinct from the previous prostate adenocarcinoma and consistent with large cell neuroendocrine carcinoma (LCNEC).
case_images: Computed tomography (CT) scan of the chest revealed multiple bilateral pulmonary and pleural-based nodules (red circles) suggestive of metastasis.
case_images: CRIONM2017-1853985.003.jpg
case_images: PMC5468577_01_CRIONM2017-1853985.003.jpg
case_images: fig3
case_images: Computed tomography (CT) scan of the chest revealed multiple bilateral pulmonary and pleural-based nodules suggestive of metastasis (Figure 3).