case_images: PMC10656791_01
case_images: (A) and (B) Clinical photographs of the patient at presentation showing multiple confluent erythematous to violaceous and brown patches extending from his left frontal region to the left temple, down to the infraorbital area, and occupying the left cheek and zygomatic area. The lesion also extended down to the left submandibular and submental regions where nodules were present, the largest of which measured approximately 3 cm. These nodules were sensitive to light palpation (C) Haematoxylin and eosin histopathology at 20x magnification of the second skin biopsy shows an irregular infiltrative pattern of mildly atypical vascular structures present predominantly in the dermis with features highly suspicious of a well-differentiated angiosarcoma. (D) CD31 immunohistochemical stain at 4x magnification highlighting the large irregularly shaped vascular channels.
case_images: 10.1177_2050313X231212988-fig1.jpg
case_images: PMC10656791_01_10.1177_2050313X231212988-fig1.jpg
case_images: fig1-2050313X231212988
case_images: These nodules were sensitive to light palpation (Figure 1(A) and 1(B)). A second deeper biopsy was taken of the cheek, showing bland infiltrating vascular proliferation with atypical endothelial cells, consistent with a low-grade angiosarcoma (Figure 1(C) and 1(D)).