case_images: PMC8597387_01
case_images: Endoscopic appearance of the colonic lesion: sessile polyp with central depression
case_images: RJME-62-1-313-fig1.jpg
case_images: PMC8597387_01_RJME-62-1-313-fig1.jpg
case_images: F1
case_images: The other was a sessile, non-ulcerated polyp, centrally depressed, with a smooth surface, measuring 20 mm, located at 50 cm from the anal verge (Figure 1).
case_images: Low-grade dysplasia tubular adenoma of the colon with oxyntic GH: (A) Low power image - the arrow points to a focus of GH; (B) Medium power image showing dysplastic tubules and oxyntic cells. HE staining: (A and B) x200. GH: Gastric heterotopia; HE: Hematoxylin-Eosin
case_images: RJME-62-1-313-fig2.jpg
case_images: PMC8597387_01_RJME-62-1-313-fig2.jpg
case_images: F2
case_images: Histological examination of this polyp identified a tubular adenoma with focal low-grade dysplasia and ectopic gastric oxyntic epithelium (Figure 2A). This epithelium showed all the elements present in normal orthotopic oxyntic mucosa sharply delimited from the surrounded tubules of the adenoma (Figure 2B).
case_images: Oxyntic GH: (A) Parietal and chief cells are present between the tubules of the adenoma; (B) Oxyntic cells show positive cytoplasmic reactivity for MUC6. HE staining: (A) x400. Anti-MUC6 antibody immunomarking: (B) x400. GH: Gastric heterotopia; HE: Hematoxylin-Eosin; MUC6: Mucin 6
case_images: RJME-62-1-313-fig3.jpg
case_images: PMC8597387_01_RJME-62-1-313-fig3.jpg
case_images: F3
case_images: Both types of cells showed small, eccentric, round, uniform nuclei (Figure 3A). The MUC6 immunoexpression was cytoplasmic (Figure 3B).