case_images: PMC5253706_01
case_images: Mammogram performed with mediolateral oblique incidences of both breasts shows multiple oval well-defined masses located in the right breast (A) and a round lesion with fine spiculated borders located on the superior quadrant of the left breast (B) associated with smaller round lesions.
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case_images: F1
case_images: A mammogram was performed with only mediolateral oblique incidences because of breast discomfort (Figure 1).
case_images: Ultrasound of both breasts demonstrates one of the multiple masses located on the right breast (A) which is characterized by an oval shape, smooth borders and a hypoechoic appearance. The palpable mass located in the upper outer quadrant of the left breast (B) presents an irregular shape and borders with posterior shadowing suggestive of malignancy.
case_images: fsurg-03-00067-g002.jpg
case_images: PMC5253706_01_fsurg-03-00067-g002.jpg
case_images: F2
case_images: Multiple similar well-defined hypoechoic oval masses were observed scattered throughout the remainder of the breasts tissue (Figure 2).
case_images: On MRI, multiple round masses are localized in the outer upper quadrant of the right breast, which present a hyperintense signal on T2-weighted images and fat saturation (A) and a hypointense signal on T1-weighted images (B). These lesions present a faint contrast enhancement on gadolinium-enhanced T1-weighted images with fat saturation (C).
case_images: fsurg-03-00067-g003.jpg
case_images: PMC5253706_01_fsurg-03-00067-g003.jpg
case_images: F3
case_images: On MRI, all lesions (Figure 3) including the palpable one (Figure 4) were hypointense on T1-weighted images and hyperintense on T2-weighted images.
case_images: On MRI, the palpable mass located in the upper outer left quadrant demonstrates a hyperintense signal on T2-weighted images with fat saturation (A) and a hypointense signal on T1-weighted images (B). After gadolinium administration, the mass shows little enhancement and a small necrotic area with enhancing borders (C).
case_images: fsurg-03-00067-g004.jpg
case_images: PMC5253706_01_fsurg-03-00067-g004.jpg
case_images: F4
case_images: On MRI, all lesions (Figure 3) including the palpable one (Figure 4) were hypointense on T1-weighted images and hyperintense on T2-weighted images.
case_images: Dense myeloid precursor proliferation with breast tissue invasion. Immunostaining is positive for myeloperoxydase, CD68 and CD117, which are markers for myeloid cells.
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case_images: F5
case_images: Biopsies were positive for myeloperoxydase (MPO), CD68, and CD117, which are markers for myeloid tumors (Figure 5).
case_images: Follow-up with MRI shows significant decrease in tumor burden with no evidence of new lesions. A complete response was achieved in most lesions and observed by the absence of contrast enhancement especially in the big cluster of oval masses of the right breast (arrow). T2-weighted images with fat saturation (A); T1-weighted images (B); gadolinium-enhanced T1-weighted images with fat saturation (C).
case_images: fsurg-03-00067-g006.jpg
case_images: PMC5253706_01_fsurg-03-00067-g006.jpg
case_images: F6
case_images: Follow-up with breast MRI (Figures 6 and 7) showed partial response of the breast disease within 1 month with complete resolution of almost all known lesions and absence of new ones: only a small fraction of focal contrast enhancements measuring up to 1 cm were observed during follow-up (Figure 8).
case_images: Here, we observe a complete response of the known palpable lesion in the left breast with absence of contrast enhancement (arrow). T2-weighted images with fat saturation (A); T1-weighted images (B); gadolinium-enhanced T1-weighted images with fat saturation (C).
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case_images: PMC5253706_01_fsurg-03-00067-g007.jpg
case_images: F7
case_images: Follow-up with breast MRI (Figures 6 and 7) showed partial response of the breast disease within 1 month with complete resolution of almost all known lesions and absence of new ones: only a small fraction of focal contrast enhancements measuring up to 1 cm were observed during follow-up (Figure 8).
case_images: Gadolinium-enhanced T1-weighted images with fat saturation showing a remaining 1-cm focal enhancement 1 month after therapy (arrow).
case_images: fsurg-03-00067-g008.jpg
case_images: PMC5253706_01_fsurg-03-00067-g008.jpg
case_images: F8
case_images: Follow-up with breast MRI (Figures 6 and 7) showed partial response of the breast disease within 1 month with complete resolution of almost all known lesions and absence of new ones: only a small fraction of focal contrast enhancements measuring up to 1 cm were observed during follow-up (Figure 8).