case_images: PMC10601766_01
case_images: Genetic map centered on the AML patient. The AML patient's father's two sisters have WM and NK/T, respectively, and one brother has AITL. The patient herself, her son, her daughter, and her two cousins had STK11 p.F354L and/or THBD p.D486Y mutations. The female with purple circle is this AML patient. WM, Waldenstrom macroglobulinemia; NK/T, NK/T-cell lymphoma; AITL, angioimmunoblastic T-cell lymphoma.
case_images: cro-2023-0016-0001-532003_F01.jpg
case_images: PMC10601766_01_cro-2023-0016-0001-532003_F01.jpg
case_images: F1
case_images: The patient's father's two sisters have Waldenstrom macroglobulinemia and NK/T-cell lymphoma, respectively, and one brother has angioimmunoblastic T-cell lymphoma (Fig. 1). Considering the possible family aggregation history of hematological malignancies of this patient, we screened genetic susceptibility genes related to blood and immune system diseases in order to find suitable transplant donors, and found that the patient herself, her son, her daughter, and her two cousins all had STK11 p.F354L and/or THBD p.D486Y mutations (Fig. 1).