case_images: PMC4334432_01
case_images: Giant black-brown pigmented nevus, one covering nearly the entire right thoracodorsal region and the other on the left thigh. Note also satellite nevi on the trunk and extremities.
case_images: CRIM2015-545603.001.jpg
case_images: PMC4334432_01_CRIM2015-545603.001.jpg
case_images: fig1
case_images: Physical examination revealed many brownish-black nevi on the trunk, including a giant one covering nearly the entire right thoracodorsal region (32 cm x 20 cm) and another on the left thigh (25 x 18 cm) (Figure 1).
case_images: Cerebral magnetic resonance imaging revealing a large expansive lesion in the left frontal region. The lesion is heterogeneous on T1 with iso- and hyperintense areas, hypointense on FLAIR, and heterogeneous and markedly hypointense on T2.
case_images: CRIM2015-545603.002.jpg
case_images: PMC4334432_01_CRIM2015-545603.002.jpg
case_images: fig2
case_images: This lesion was heterogeneous on T1 with iso- and hyperintense areas, hypointense on FLAIR, and heterogeneous and markedly hypointense on T2 (Figure 2).
case_images: Marked cellular pleomorphism and numerous mitotic figures. Immunohistochemical examination showed S100(+), HMB45(+), MelanA(+), and MiTF(+).
case_images: CRIM2015-545603.003.jpg
case_images: PMC4334432_01_CRIM2015-545603.003.jpg
case_images: fig3
case_images: Postsurgically pathological diagnosis showed brain involvement of neoplastic cells with characteristics of melanoma (Figure 3).
case_images: Reflecting widespread leptomeningeal infiltration, contrast capture was documented in the subarachnoid space from the level of C2-C3.
case_images: CRIM2015-545603.004.jpg
case_images: PMC4334432_01_CRIM2015-545603.004.jpg
case_images: fig4