case_images: PMC10751923_01
case_images: PMC10751923_02
case_images: Histopathological examination of the liver biopsy specimen. (A) Nodule formation with a thick fibrous septa was noted and considered representative of advanced cirrhosis (Masson's trichrome stain). (B) No interlobular bile duct was noted in the enlarged portal tract. Interface inflammation was also noted (hematoxylin and eosin stain). (C) Immunohistochemical staining for CK7 revealed a complete absence of bile ducts in the portal tracts. (D) The periportal hepatocytes showed marked ballooning changes with abundant copper deposition (arrows) (Rhodanine stain).
case_images: fped-11-1280409-g001.jpg
case_images: PMC10751923_02_fped-11-1280409-g001.jpg
case_images: F1
case_images: Pathological examination revealed advanced liver cirrhosis (Figure 1A) with a paucity of interlobular bile ducts; this finding was confirmed by the results of immunohistochemical (IHC) staining for CK7 (Figures 1B,C) and a marked increase in copper deposition in the periportal areas (Figure 1D).