case_images: PMC10666783_01
case_images: Endoscopic and ultrasonographic features of gastroblastoma. (A) A protuberant submucosal mass was detected on the greater curvature of gastric body with ulceration in the center of the mucosal surface. (B) A low hypoechoic nodule located in the muscle layer of the gastric wall with clear boundary and regular shape (arrow). (C) The tumor protruded into the gastric cavity with uneven internal echo (arrow). (D) Color Doppler flow imaging showed strip blood flow signals. Black arrow indicates the tumor (arrow).
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case_images: PMC10666783_01_fonc-13-1198762-g001.jpg
case_images: f1
case_images: An endoscopic examination was performed, and a protuberant submucosal mass measuring 3.3 cm x 3.2 cm was detected on the greater curvature of the gastric body with ulceration in the center of the mucosal surface ( Figure 1A ). A low hypoechoic nodule (2.7 cm x 2.1 cm) was detected in the muscle layer of the gastric wall, with a clear boundary and regular shape ( Figure 1B ). The tumor protruded into the gastric cavity with uneven internal echo ( Figure 1C ). Color Doppler flow imaging (CDFI) showed several strip blood flow signals that could be seen around the nodule ( Figure 1D ).
case_images: CT imaging features of gastroblastoma. (A) CT scan showed a nodule with homogeneous density and well-circumscribed on the lesser curvature of stomach (arrow). (B) Obvious and heterogeneous enhancement in arterial phase (arrow). (C) Further enhancement in venous phase (arrow). (D) Enhancement density of the lesion decreased in delayed phase (arrow).
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case_images: PMC10666783_01_fonc-13-1198762-g002.jpg
case_images: f2
case_images: An abdominal enhanced computed tomography (CT) scan showed a 2.2 cm x 2.5 cm nodule with homogeneous density and well-circumscribed on the greater curvature of the stomach, which showed obvious and heterogeneous enhancement in the arterial phase, with further enhancement in the venous phase and decreased density in the delayed phase ( Figure 2 ).
case_images: Histopathological findings of gastroblastoma. (A) Tumor located in the submucosa and muscularis propria with well-demarcated boundary. (B) Epithelial cells are arranged in nests, and the stroma is rich in thin-walled blood vessels. (C) Transition of epithelial cells and spindle cells. (D) Epithelial cells were strongly and diffusely positive for CAM5.2. (E) Part of epithelial cells were strongly positive for CD10. (F) Both epithelial cells and spindle cells were strongly nuclear and cytoplasmic positive for Gli1.
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case_images: PMC10666783_01_fonc-13-1198762-g003.jpg
case_images: f3
case_images: Histologically, the tumor is located in the submucosa and muscularis propria with a well-demarcated boundary ( Figure 3A ). The tumor was rich in cavernous hemangioma-like vascular structures ( Figure 3B ). The spindle cell component was less and with a fascicular growth pattern with pale eosinophilic cytoplasm ( Figure 3C ). The epithelial cells also strongly expressed CD56 and CAM5.2 ( Figure 3D ) and showed weak staining for CK and focal staining for CD10 ( Figure 3E ), whereas the spindle cell component lacked expression of CD56 and CAM5.2. Both the epithelial component and spindle cell component were nuclear and cytoplasmic positive for Gli1 ( Figure 3F ).