case_images: PMC9092942_01
case_images: Changes of hemangioblastoma of the magnetic resonance imaging (MRI). (A) A space-occupying lesion at L1-L2 was detected (red arrow) in May 2016; (B) A recurrent site at S1 was observed (red arrow) after the first surgery in July 2019; (C) Two recurrent sites at L2 and S1-S2 were discovered (red arrow) after the second surgery in June 2020.
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case_images: f1
case_images: The magnetic resonance imaging (MRI) showed a space-occupying lesion at L1-L2 ( Figure 1A ). She underwent a MRI of the lumbar spine which showed a space-occupying lesion at S1 ( Figure 1B ), thus the tumor resection was performed again. In June 2020, MRI indicated tumor recurrence at L2 and S1-S2 ( Figure 1C ).
case_images: Anlotinib resulted in tumor regression of multiple recurrent lumbar and sacral cord hemangioblastoma. This is a sagittal magnetic resonance imaging (MRI) view of lumbar and sacral spine; (A) The two lesions at L2 and S1-S2 were observed to have increased in size (red arrow) in June 2021; (B) The MRI demonstrated tumor regression (red arrow) following one month of anlotinib in July 2021; (C) The MRI showed further regression in the enhancing tumor (red arrow) following three months of anlotinib in Sep 2021.
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case_images: f2
case_images: In June 2021, tumor progression was observed. the MRI showed that the diameter of two lesions at L2 and S1-S2 increased to 1.8cm and 2.3cm respectively ( Figure 2A ). T2 signal change around the enhancing component, as well as a decrease in the size on the MRI from 1.8cm to 1.0cm at L2 and from 2.3cm to 2.0cm at S1-S2 after use of one month ( Figure 2B ). To date of Sep 22, 2021, the MRI demonstrated further decrease in the dimensions of residual lesions ( Figure 2C ). The patient was in good condition, evaluated as having partial response in accordance with the RECIST 1.1 system.
case_images: The treatment timeline of the patient with multiple recurrent hemangioblastoma.
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case_images: PMC9092942_01_fonc-12-859157-g003.jpg
case_images: f3
case_images: The treatment timeline of the patient is depicted in  Figure 3 . The patient has given her consent for the case report to be published.