case_images: PMC10725639_01
case_images: Clinical presentation of cytophagic histiocytic panniculitis lesions. (A) Symmetric edematous erythematous plaque on cheeks; (B and C) Subcutaneous nodules and edema on abdomen and legs.
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case_images: Disseminated irregular painful nodules measuring 1 to 2cm were mainly found on the trunk and extremities (Figure 1).
case_images: Hematoxylin-Eosin (HE) and immunohistochemical staining of skin biopsy. (A) HE staining showed histiocytophagy ("beanbag-like" cells, red arrow), degeneration of adipocytes within the fat lobules, infiltration with small mature lymphocytes and histiocytes. (B) Increased expression of CD3, CD8, GranzymeA and TIA-1, negative expression of CD4, CD56, Ki67 and Perforin in immunohistochemical staining. The scale bar is 200 mum for the 20X images.
case_images: CCID-16-3541-g0002.jpg
case_images: PMC10725639_01_CCID-16-3541-g0002.jpg
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case_images: Immunohistochemistry showed CD3(+), CD8(+), GranzymeA(+), TIA-1(+), Ki67(<5%+), CD4(-), Perforin(-), EBER(-), CD56(-), and negative TCR gene rearrangement (Figure 2A and B). 