case_images: PMC11221979_01
case_images: Positron emission tomography/computed tomography with fluorodeoxyglucose avidity in right posterior mandible. A right mandibular exophytic mass measuring 5.0 x 4.0 cm is identified.
case_images: CRIONM2024-2418888.001.jpg
case_images: PMC11221979_01_CRIONM2024-2418888.001.jpg
case_images: fig1
case_images: Positron emission tomography/computed tomography imaging revealed an exophytic mass, measuring 5.0 x 4.0 cm (Figure 1).
case_images: Intraoperative clinical photographs. (a) Surgical defect following composite segmental mandibulectomy with condylar disarticulation via lip split. (b) Surgical defect with mandibular reconstruction plate with alloplastic condylar prosthesis in place. (c) Anterolateral thigh flap in place for soft tissue reconstruction. Photograph of gross specimen (arrow, mandibular condyle).
case_images: CRIONM2024-2418888.002.jpg
case_images: PMC11221979_01_CRIONM2024-2418888.002.jpg
case_images: fig2
case_images: The specimen contained soft tissue and skeletal muscle adherent to the mandible, and the mucosal surface was markedly distorted by multiple soft to firm, tan, exophytic nodules, the largest of which measured 3.5 x 3.1 x 2.5 cm (Figure 2). Tumor and nontumor (benign parotid tissue) DNA samples were collected from the specimen (Figure 2).
case_images: High-power view of hematoxylin and eosin-stained section of the telangiectatic osteosarcoma. The black arrows show osteoid formation. The white arrow shows a blood-filled cyst, typical of this lesion. The tumor stroma is dominated by highly pleomorphic osteoid-producing malignant mesenchymal cells (green arrows).
case_images: CRIONM2024-2418888.003.jpg
case_images: PMC11221979_01_CRIONM2024-2418888.003.jpg
case_images: fig3
case_images: Hematoxylin and eosin-stained sections of the tumor revealed pleomorphic epithelioid cells in a matrix containing osteoid, numerous blood-filled spaces lined by pleomorphic epithelioid cells, with occasional giant cell formation and abnormal mitoses (Figure 3).
case_images: A diagram of the patient's family tree showing an increased cancer incidence descended from the patient's paternal grandmother. Women are depicted with black circles and men with white squares.
case_images: CRIONM2024-2418888.004.jpg
case_images: PMC11221979_01_CRIONM2024-2418888.004.jpg
case_images: fig4
case_images: Additionally, the patient's 40-year-old son had melanoma (Figure 4).