case_images: PMC11003585_01
case_images: Bone marrow biopsy showing changes in myelofibrosis (40 x magnification).
case_images: IJN-34-064-g001.jpg
case_images: PMC11003585_01_IJN-34-064-g001.jpg
case_images: F1
case_images: He had a history of hypertension for 20 years and biopsy-proven myelofibrosis [Figure 1] for 10 years with JAK2 mutation positivity, for which he was on hydroxyurea and aspirin.
case_images: A glomerulus showing proliferative changes with partial cellular crescent under light microscopy (hematoxylin and eosin stain, x40).
case_images: IJN-34-064-g002.jpg
case_images: PMC11003585_01_IJN-34-064-g002.jpg
case_images: F2
case_images: Kidney biopsy which showed 3/10 glomeruli globally sclerosed, with a partial cellular crescent [Figure 2] in one glomerulus and rest of the glomeruli showing mild mesangial proliferation with normal glomerular basement membrane and normal capillary lumens without any fibrin thrombi, mild mixed infiltration in the interstitium, and mild interstitial edema and occasional foci of tubular atrophy with no interstitial fibrosis and normal blood vessels.
case_images: Electron microscopy showing focal effacement of foot process and few mesangial and subendothelial deposits (magnification: 2000x).
case_images: IJN-34-064-g003.jpg
case_images: PMC11003585_01_IJN-34-064-g003.jpg
case_images: F3
case_images: There was focal deposition of mesangial and subendothelial electron-dense deposits [Figure 3] and few foci of tubuloreticular lesions in endothelial cells without any subendothelial electrolucent fluffy deposit and normal capillary lumen [Figure 4].
case_images: Electron microscopy showing tubuloreticular inclusions in endothelial cells (magnification: 5300x).
case_images: IJN-34-064-g004.jpg
case_images: PMC11003585_01_IJN-34-064-g004.jpg
case_images: F4
case_images: There was focal deposition of mesangial and subendothelial electron-dense deposits [Figure 3] and few foci of tubuloreticular lesions in endothelial cells without any subendothelial electrolucent fluffy deposit and normal capillary lumen [Figure 4].