case_images: PMC10803416_01
case_images: Preoperative CT images and Three-Dimensional Reconstructed CT. (A) Tumor in S8: before contrast, arterial phase and portal venous phase; (B) Tumor in S5: before contrast, arterial phase and portal venous phase; (C) Arterial relationships with tumors on 3D Reconstructed Images; (D) The relationship between veins and tumors on 3D Reconstructed Images.
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case_images: PMC10803416_01_fonc-13-1309798-g001.jpg
case_images: f1
case_images: The image of tumor in S8 was shown in  Figure 1A . In the latter lesions, the enhancement in the arterial phase showed obvious uneven enhancement, and the enhancement in the venous phase and the delayed phase decreased, showing relatively low density ( Figure 1B ). Three-Dimensional Reconstructed CT of liver parenchyma, tumor, and vessels showed that there was no variation in hepatic artery, hepatic vein, and portal vein ( Figures 1C, D ).
case_images: The gross examination of the surgical specimen, as well as histopathological analysis and immunohistochemical examination, the tumor in S5 comprises two distinct components: large-cell neuroendocrine carcinoma and hepatocellular carcinoma. (A) The macroscopic specimen; (B) Hematoxylin-eosin staining; (C) for CD56 staining; (D) Heppar-1 staining; (E) Ki-67 staining.
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case_images: f2
case_images: To the naked eye, the tumor in S5 and S8 were solid and yellowish-white in color with some necrotic changes ( Figure 2A ). Immunohistochemistry shows CgA (-),CD56 (+diffuse), Ki-67 (+80%), Heppar-1 (+) ( Figures 2B-E ).
case_images: Immunohistochemical staining of TP53 gene in excised specimens. (A) TP53 gene staining in paracancer sample. (B-D) TP53 gene staining in tumor sample.
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case_images: We found that p53 gene was almost not expressed in paracancer sample, while it was expressed in tumor sample ( Figure 3 ).
case_images: Postoperative Follow-up of the Patient: (A) Whole-body PET-CT examination three months after surgery; (B) Tumor in S8, eight months after surgery: before contrast, arterial phase, and portal venous phase; (C) Tumor in S5, eight months after surgery: before contrast, arterial phase, and portal venous phase.
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case_images: f4
case_images: Three months after the patient's surgery, we performed a whole-body PET-CT examination on the patient ( Figure 4A ). To date, eight months post-surgery, the patient has not exhibited any significant signs of recurrence ( Figures 4B, C ).