case_images: PMC4283451_01
case_images: Pedigree of the family (IV-7: proband-with arrow, IV-1, 2, 3: ex siblings with the same phenotype, IV-4, 5: miscarriage, and IV-6: healthy sibling with cleft palate).
case_images: CRID2014-605892.001.jpg
case_images: PMC4283451_01_CRID2014-605892.001.jpg
case_images: fig1
case_images: She was the seventh child of healthy parents who were first cousins (Figure 1).
case_images: Frontal view of the proband. Note the broad nasal bridge, root, and tip, protruding ears, and bifid frenula.
case_images: CRID2014-605892.002.jpg
case_images: PMC4283451_01_CRID2014-605892.002.jpg
case_images: fig2
case_images: She had a broad nasal bridge, root, and tip, protruding ears, and bifid frenula (Figure 2).
case_images: Lateral view of the patient. Note the retrognathic mandible.
case_images: CRID2014-605892.003.jpg
case_images: PMC4283451_01_CRID2014-605892.003.jpg
case_images: fig3
case_images: Class III malocclusion (Figure 3). Cutaneous lesions below her lower lip were suggestive of self-injurious behaviour.
case_images: Hands of the patient. Note the surgery scars.
case_images: CRID2014-605892.004.jpg
case_images: PMC4283451_01_CRID2014-605892.004.jpg
case_images: fig4
case_images: She had broad hands, with syndactyly and polydactyly of both hands, and bilateral bifid thumbs (Figure 4).
case_images: Feet of the patient. Note bilateral talipes equinovarus.
case_images: CRID2014-605892.005.jpg
case_images: PMC4283451_01_CRID2014-605892.005.jpg
case_images: fig5
case_images: She had bilateral talipes equinovarus (Figure 5).
case_images: Tongue of the patient. Note the surgery scars secondary to tumor-like lesions.
case_images: CRID2014-605892.006.jpg
case_images: PMC4283451_01_CRID2014-605892.006.jpg
case_images: fig6
case_images: Intraoral examination revealed cleft palate and a pseudo-cleft lip, sublingual hamartoma, and lobulated tongue that had been operated on bilaterally because of tumor-like lesions (Figure 6).
case_images: Panoramic radiograph of the patient.
case_images: CRID2014-605892.007.jpg
case_images: PMC4283451_01_CRID2014-605892.007.jpg
case_images: fig7
case_images: Her panoramic radiograph revealed oligodontia with congenitally absent upper permanent second premolars, the lower permanent central incisors, the left lateral incisor, and the right second premolar (Figure 7).