case_images: PMC10482420_01
case_images: Copies of number variation data derived from peripheral blood from the patients. The horizontal axis represents the position of the chromosome, and the vertical axis represents the log2 value of the copy number. Gray dots represent each sliding window interval (bin), while orange dots represent each segment.
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case_images: PMC10482420_01_fcimb-13-1227537-g001.jpg
case_images: f1
case_images: The CNV analysis through host sequence suggests high-risk liver problems (as shown in  Figure 1 ). Figures S1 ,  S2 . From the above results, we diagnosed the patient with M. kansasii endocarditis, decompensated liver cirrhosis (hepatitis B and alcohol-related), splenic infarction, peritonitis, and agranulocytosis.
case_images: Flow cytometry immunofluorescence analysis results. Y-axis: lateral scattering intensity linear (SS INT LIN); X-axis: the account of CD45 detected by optical filter centered near 500 nm. The dark green color represents granulocyte, the purple color represents monocytes, the red color represents weak expressing CD45 cells, and the light green represents CD45 negative cells.
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case_images: PMC10482420_01_fcimb-13-1227537-g002.jpg
case_images: f2
case_images: T cells accounted for 88.3% of lymphocytes, NK cells accounted for 2.4%, and B cells accounted for 2.7%. The CD4:CD8 ratio was 1.20, indicating no significant immune abnormalities ( Figure 2 ). Figures S1 ,  S2 . From the above results, we diagnosed the patient with M. kansasii endocarditis, decompensated liver cirrhosis (hepatitis B and alcohol-related), splenic infarction, peritonitis, and agranulocytosis.
case_images: Cardiac color Doppler ultrasound. There is a slightly echogenic mass measuring approximately 10 mm x 5mm on the aortic valve, with low mobility. (A) The long-axis view of the left ventricle next to the sternum shows an attached vegetation on the aortic valve without coronary valve involvement. (B) The short-axis view of the left ventricle next to the sternum shows the formation of a vegetation on the aortic valve without coronary valve involvement. A small amount of fluid-filled dark area is visible in the pericardial cavity, with an anterior-posterior diameter of 3 mm.
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case_images: PMC10482420_01_fcimb-13-1227537-g003.jpg
case_images: f3
case_images: Echocardiograms were performed on the second and eighth day after admission, revealing vegetation measuring 10x5 mm on the margin of the aortic valve, specifically the non-coronary valve ( Figure 3 ).
case_images: Abdominal contrast-enhanced computed tomography cross-section. The liver is fully voluminous and has a uniform density. The spleen is significantly enlarged and thickened, with the thickest part measuring approximately 82 mm. The edges are rounded, and the lower border of the spleen is below the lower border of the liver. There are multiple hypointense or non-enhancing wedge-shaped areas near the edge of the spleen, suggesting splenic infarction (arrows). A nodular accessory spleen is also observed along the inner edge of the spleen.
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case_images: PMC10482420_01_fcimb-13-1227537-g004.jpg
case_images: f4
case_images: Furthermore, multiple wedge-shaped areas near the edge of the spleen parenchyma, appearing as hypo-enhancing or non-enhancing regions, were indicative of splenic infarction ( Figure 4 ).