case_images: PMC11785514_01
case_images: Frontal scout view showing the right cervical nodal conglomerate with an SUVmax of 12.7 on the left and complete resolution after therapy on the right . SUV: standardized uptake value
case_images: cureus-0017-00000076733-i01.jpg
case_images: PMC11785514_01_cureus-0017-00000076733-i01.jpg
case_images: FIG1
case_images: Three months later, he unfortunately developed fluorodeoxyglucose (FGD) avid, right-cervical lymphadenopathy with a standardized uptake value (SUV)max of 12.7 (Figure 1 and Figure 2). The end-of-treatment PET/CT demonstrated a complete absence of both the right cervical conglomerate and the mass in the right lower extremity following the completion of treatment (Figure 1).
case_images: Axial views showing the cervical conglomerate on the left and complete resolution after therapy on the right
case_images: cureus-0017-00000076733-i02.jpg
case_images: PMC11785514_01_cureus-0017-00000076733-i02.jpg
case_images: FIG2
case_images: Three months later, he unfortunately developed fluorodeoxyglucose (FGD) avid, right-cervical lymphadenopathy with a standardized uptake value (SUV)max of 12.7 (Figure 1 and Figure 2).
case_images: Morphologic and immunophenotypic features of plasmablastic lymphoma. (A) H&E of plasmablastic lymphoma (x200). (B) CD138 immunostain staining abundantly positive (x200). (C) Kappa in situ hybridization study demonstrating kappa restriction consistent with a monoclonal plasma cell population (x200). (D) EBV in situ hybridization study demonstrating EBV positivity (x200). H&E: hematoxylin and eosin; EBV: Epstein-Barr virus
case_images: cureus-0017-00000076733-i03.jpg
case_images: PMC11785514_01_cureus-0017-00000076733-i03.jpg
case_images: FIG3
case_images: The hematoxylin and eosin (H&E) section of the needle core biopsy showed complete effacement of the lymphoid architecture, replaced by sheets of lymphoma cells (Figure 3A). The lymphoma cells were positive for CD138 (Figure 3B), MUM1, and C-MYC and negative for CD20, CD30, CD79a, PAX5, ALK-1, and HHV-8. In situ hybridization studies showed monoclonal kappa expression and positivity for EBV (Figure 3C, 3D).