case_images: PMC11282564_01
case_images: (a) Hand eczema before treatment. (b) After 3-day treatment of topical ozone therapy. (c) After 9-day treatment of topical ozone therapy.
case_images: 10.1177_2050313X241260471-fig1.jpg
case_images: PMC11282564_01_10.1177_2050313X241260471-fig1.jpg
case_images: fig1-2050313X241260471
case_images: The present case reports a 46-year-old man who was referred to our department because of a year-long history of pruritic rash, symmetrical erythema, scale, fissure, and pustules on the hands and wrists (Figure 1(a)). Histology indicated (Figure 1(a)) excessive keratinization with incomplete keratinization, pustules in the stratum corneum, local sponge edema in the epidermal and infiltration by lymphocytes, dermal papillary edema, and lymphocytes and eosinophils infiltration in the upper dermis (Figure 2). After the 3-day treatment, the lesion was markedly improved (Figure 1(b)), with most of the pustules subsiding and the scale decreased. Nine days later, the erosion surface and fissure healed, pustules disappeared, and swelling of the hands and wrists was greatly decreased (Figure 1(c)).
case_images: A biopsy of the right hand showed the presence of local sponge edema in the epidermal and infiltrated lymphocytes, lymphocytes, and eosinophils infiltrated in the upper dermis.
case_images: 10.1177_2050313X241260471-fig2.jpg
case_images: PMC11282564_01_10.1177_2050313X241260471-fig2.jpg
case_images: fig2-2050313X241260471
case_images: Histology indicated (Figure 1(a)) excessive keratinization with incomplete keratinization, pustules in the stratum corneum, local sponge edema in the epidermal and infiltration by lymphocytes, dermal papillary edema, and lymphocytes and eosinophils infiltration in the upper dermis (Figure 2).