case_images: PMC8275115_01
case_images: MRI of postoperative right renal percutaneous nephrostomy. (A) The axial T2-weighted MR images showing right renal atrophy, empyema in the right upper ureter with increased thickness and signal intensity in the perinephric fat and Gerota's fascia; there is a water balloon of nephrostomy tube (red head of arrow). (B and C) MRI showed no abnormal diffusion restriction in the right kidney.
case_images: OTT-14-4119-g0001.jpg
case_images: PMC8275115_01_OTT-14-4119-g0001.jpg
case_images: f0001
case_images: Gerota's fascia (Figure 1). Then, the patient underwent laparoendoscopic nephrectomy and partial ureterectomy for pyonephrotic nonfunctioning kidneys. Grossly, the tumor appeared as exophytic, cauliflower-shaped like mass in the right renal pelvis (3.5x2.5x2.0 cm3) (red arrow); and there was another tumor with invasive growth at the ureteropelvic junction (black arrow) (Figure 2).
case_images: Grossly, the tumor appeared as exophytic, cauliflower-shaped like mass in the right renal pelvis (3.5x2.5x2.0 cm3) (red arrow); at the ureteropelvic junction, there was another tumor with invasive growth that caused an obstruction of ureter (black arrow).
case_images: OTT-14-4119-g0002.jpg
case_images: PMC8275115_01_OTT-14-4119-g0002.jpg
case_images: f0002
case_images: Gerota's fascia (Figure 1). Then, the patient underwent laparoendoscopic nephrectomy and partial ureterectomy for pyonephrotic nonfunctioning kidneys. Grossly, the tumor appeared as exophytic, cauliflower-shaped like mass in the right renal pelvis (3.5x2.5x2.0 cm3) (red arrow); and there was another tumor with invasive growth at the ureteropelvic junction (black arrow) (Figure 2).
case_images: Pathological features of the carcinoma of upper ureter: (A) H&E showing urothelial squamous metaplasia; (B) positive immunostaining in tumor cells with CK5/6; (C) intense positive immunostaining for CK-HMW (+) in tumor cells; (D) positive immunostaining in tumor cells with CK8/18 (+++); (E) positive immunostaining in tumor cells with CK7 (+); (F) positive immunostaining in tumor cells with Vim (focal +); (G) tumor cell proliferation rate as determined by Ki-67 immunostaining showed 60% of positive cells.
case_images: OTT-14-4119-g0003.jpg
case_images: PMC8275115_01_OTT-14-4119-g0003.jpg
case_images: f0003
case_images: Postoperative pathology showed high-grade urothelial carcinoma of the upper ureter with immunohistochemistry (IHC): CK-HMW (+), CK5/6 (+++), Vimentin (focal +), CK8/18 (+++), CK7 (++), Ki-67 (60%+) (Figure 3); the immunohistochemistry results of pelvic neoplasms: CK5/6 (focal +), CK-HMW (focal +), CK8/18 (focal +), CK7 (focal +), Vimentin (+++), Ki-67 (85%+), SMA (-), CD10 (-) (Figure 4).
case_images: Pathological features of the carcinoma of pelvic neoplasms: (A) H&E showing abundant fibroblastic epithelioid cells densely arranged in cords, nests, or sheets within a collagenous extracellular matrix; (B) positive immunostaining in tumor cells with CK5/6 (focal +); (C) positive immunostaining for CK-HMW (focal +) in tumor cells; (D) positive immunostaining for CK7 (focal +) in tumor cells; (E) positive immunostaining in tumor cells with CK8/18 (focal +); (F) intense positive immunostaining in tumor cells with Vim (+++); (G) tumor cell proliferation rate as determined by Ki-67 immunostaining showed 85% of positive cells; (H) negative immunostaining in tumor cells with CD 10; (I) negative immunostaining for SMA in tumor cells.
case_images: OTT-14-4119-g0004.jpg
case_images: PMC8275115_01_OTT-14-4119-g0004.jpg
case_images: f0004
case_images: Postoperative pathology showed high-grade urothelial carcinoma of the upper ureter with immunohistochemistry (IHC): CK-HMW (+), CK5/6 (+++), Vimentin (focal +), CK8/18 (+++), CK7 (++), Ki-67 (60%+) (Figure 3); the immunohistochemistry results of pelvic neoplasms: CK5/6 (focal +), CK-HMW (focal +), CK8/18 (focal +), CK7 (focal +), Vimentin (+++), Ki-67 (85%+), SMA (-), CD10 (-) (Figure 4).