case_images: PMC10183565_01
case_images: The lesion in the left lobe of liver was detected on CT.
case_images: fonc-13-1146933-g001.jpg
case_images: PMC10183565_01_fonc-13-1146933-g001.jpg
case_images: f1
case_images: Abdominal computed tomography (CT) showed the lesion in the left lobe of liver was detected, and no tumor was detected in any other organs (Figure 1).
case_images: Magnetic Resonance Imaging showed a 1.1x1.3 cm lesion in the left lobe of liver. (A) low signal intensity on T1-weighted images; (B) high signal intensity on T2-weighted images; (C) ring enhancing on DWI image; (D) ADC image of the lesion (ADC value: 800).
case_images: fonc-13-1146933-g002.jpg
case_images: PMC10183565_01_fonc-13-1146933-g002.jpg
case_images: f2
case_images: The MRI showed a 1.1x1.3 cm lesion in the left lobe of liver, appearing low signal intensity on T1-weighted images and high signal intensity on T2-weighted images (Figure 2).
case_images: Pathological examination and immunohistochemical staining. (A) Tumor was composed of undifferentiated epithelial cells with some atypical glands, and significant lymphocytic infiltration (HE stain, x20); (B, C) Lymphatic tissue positive for CD20 (B-cells, B, x20), CD3 (T-cells, C, x20); (D) tumor cells positive for CK7 (immunostaining, x20).
case_images: fonc-13-1146933-g003.jpg
case_images: PMC10183565_01_fonc-13-1146933-g003.jpg
case_images: f3
case_images: Microscopically, the lesion composed of undifferentiated epithelial cells with some atypical glands, and significant lymphocytic infiltration (Figure 3A). In addition, immunohistochemical analysis showed the lymphatic tissue positive for CD20 (B-cells, Figure 3B), CD3 (T-cells, Figure 3C), Ki-67 and negative for IgG4. Meanwhile, tumor cells positive for CK7 (Figure 3D), and negative for CK20, supporting the diagnosis of LEL-ICC.
case_images: CT showed the patient was free from tumor recurrence after a 28 months follow-up.
case_images: fonc-13-1146933-g004.jpg
case_images: PMC10183565_01_fonc-13-1146933-g004.jpg
case_images: f4
case_images: The patient was free from tumor recurrence after a 28 months follow-up (Figure 4).