case_images: PMC10380939_01
case_images: T2 fluid-attenuated inversion recovery (FLAIR) of brain magnetic resonance imaging (MRI). [A-H patient 1, I-P patient 2]. T2 FLAIR brain MRI of patient 1 at initial presentation demonstrated hyperintensities involving the brainstem, left frontal, parietal, and temporal cortex (A, B). T2 FLAIR brain MRI after admission to our hospital and suffering from status epilepticus demonstrated hyperintensities involving the left frontal cortex and bilateral temporo-parietal cortex (C, D). Repeat T2 FLAIR brain MRI three weeks after immunotherapy initiation showed improvement in the bilateral temporo-parietal cortex (E, F). There were no obvious lesions on images seven months after the initial treatment (G, H). Axial T2 FLAIR brain MRI of patient 2 at initial presentation demonstrated hyperintensities involving the left temporal, parietal, and occipital cortex (I, J). T2 FLAIR brain MRI ten days after immunotherapy initiation was normal (K, L). T2 FLAIR brain MRI after disease relapse demonstrated multiple hyperintensities, in keeping with acute disseminated encephalomyelitis involving the bilateral thalamus, basal ganglia, and right centrum semiovale (M, N). At re-assessment four months after second discharge, the patient was clinically asymptomatic with improving FLAIR lesions on repeat T2 FLAIR brain MRI (O, P).
case_images: fimmu-14-1203615-g001.jpg
case_images: PMC10380939_02_fimmu-14-1203615-g001.jpg
case_images: f1
case_images: Brain MRI showed FLAIR hyperintensity in the left temporal, parietal, and occipital cortex and there was no contrast enhancement, see  Figures 1I, J . Repeated brain MRI showed no obvious lesions, see  Figures 1K, L . Brain MRI showed multiple FLAIR hyperintensity, in keeping with acute disseminated encephalomyelitis involving the bilateral thalamus, basal ganglia, and right centrum semiovale, see  Figures 1M, N . At re-assessment four months after discharge, she was clinically asymptomatic with improving FLAIR lesions on repeat brain MRI, see  Figures 1O, P .
case_images: PMC10380939_02
case_images: T2 fluid-attenuated inversion recovery (FLAIR) of brain magnetic resonance imaging (MRI). [A-H patient 1, I-P patient 2]. T2 FLAIR brain MRI of patient 1 at initial presentation demonstrated hyperintensities involving the brainstem, left frontal, parietal, and temporal cortex (A, B). T2 FLAIR brain MRI after admission to our hospital and suffering from status epilepticus demonstrated hyperintensities involving the left frontal cortex and bilateral temporo-parietal cortex (C, D). Repeat T2 FLAIR brain MRI three weeks after immunotherapy initiation showed improvement in the bilateral temporo-parietal cortex (E, F). There were no obvious lesions on images seven months after the initial treatment (G, H). Axial T2 FLAIR brain MRI of patient 2 at initial presentation demonstrated hyperintensities involving the left temporal, parietal, and occipital cortex (I, J). T2 FLAIR brain MRI ten days after immunotherapy initiation was normal (K, L). T2 FLAIR brain MRI after disease relapse demonstrated multiple hyperintensities, in keeping with acute disseminated encephalomyelitis involving the bilateral thalamus, basal ganglia, and right centrum semiovale (M, N). At re-assessment four months after second discharge, the patient was clinically asymptomatic with improving FLAIR lesions on repeat T2 FLAIR brain MRI (O, P).
case_images: fimmu-14-1203615-g001.jpg
case_images: PMC10380939_02_fimmu-14-1203615-g001.jpg
case_images: f1
case_images: Brain MRI showed FLAIR hyperintensity in the left temporal, parietal, and occipital cortex and there was no contrast enhancement, see  Figures 1I, J . Repeated brain MRI showed no obvious lesions, see  Figures 1K, L . Brain MRI showed multiple FLAIR hyperintensity, in keeping with acute disseminated encephalomyelitis involving the bilateral thalamus, basal ganglia, and right centrum semiovale, see  Figures 1M, N . At re-assessment four months after discharge, she was clinically asymptomatic with improving FLAIR lesions on repeat brain MRI, see  Figures 1O, P .