case_images: PMC10824918_01
case_images: PMC10824918_02
case_images: PMC10824918_03
case_images: PMC10824918_04
case_images: PMC10824918_05
case_images: Shows the trends in serum Na+ (black line) and serum creatinine (Cr; blue line) as a function of days since the patient started adjuvant abemaciclib. After the onset of SIADH and hyponatremia, it was recommended to hold abemaciclib for 4 weeks, which resulted in a normalization of serum Na+ levels. The patient has since resumed and continues to take abemaciclib with a recommendation for fluid restriction.
case_images: fmed-10-1338566-g001.jpg
case_images: PMC10824918_05_fmed-10-1338566-g001.jpg
case_images: fig1
case_images: Management included a recommendation to hold abemaciclib for 4 weeks, which resulted in a near-resolution of hyponatremia (Figure 1) as well as fluid restriction.
case_images: PMC10824918_06