case_images: PMC10949540_01
case_images: Numerous skin nodules discrete at the back.
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case_images: Numerous painless skin nodules were noticed on the back by herself for several weeks (Figure 1).
case_images: Photofundus of the right and left eye.
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case_images: There were scatter dot/blot hemorrhages with no exudation, vitritis, vasculitis, or retinitis (Figure 2).
case_images: Optical coherence tomography (OCT). (a) Initial presentation of OCT demonstrated cystoid macular edema of the right eye. (b) Initial presentation of OCT demonstrated cystoid macular edema of the left eye. (c) After treatment, OCT demonstrated resolution of cystoid macular edema of the right eye. (d) After treatment, OCT demonstrated resolution of cystoid macular edema of the left eye.
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case_images: Interestingly, marked CME with prominence in the inner retinal layers was found in both eyes with a central foveal thickness of 295, 297 microm on optical coherence tomography (OCT) (Carl Zeiss Meditec, INC, Dublin, CA, USA) (Figure 3(a) and (b)). Disc hyperemia and CME were reduced (Figure 3(c) and (d)).
case_images: Histopathological findings. (a) Prominent histiocytic infiltration with emperipolesis (arrow). (b) Positive staining for CD68 histiocytic infiltrate showed emperipolesis (arrow). (c) Positive staining for S100 histiocytic infiltration showed emperipolesis (arrow). (d) Negative staining for CD1a.
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case_images: The pathological result showed abnormal granulomatous infiltration and emperipolesis (Figure 4(a)). The immunohistochemical study demonstrated the presence of CD68 positive, S100 positive, and CD1a negative (Figure 4(b)-(d)), which was consistent with the diagnosis of RDD.