case_images: PMC9039219_01
case_images: Clinical manifestation of pemphigoid nodularis in the studied patients:disseminated nodules, excoriations, hyperpigmentation, and hypopigmentation in (A) patient 1 (P1), (B) patient 2 (P2), (C) patient 3 (P3), and (D) patient 5 (P5).
case_images: fimmu-13-885023-g001.jpg
case_images: PMC9039219_05_fimmu-13-885023-g001.jpg
case_images: f1
case_images: During the last 3 years, the patient complained of persisting severe itching and presented exclusively disseminated nodules ( Figure 1D ).
case_images: PMC9039219_02
case_images: Clinical manifestation of pemphigoid nodularis in the studied patients:disseminated nodules, excoriations, hyperpigmentation, and hypopigmentation in (A) patient 1 (P1), (B) patient 2 (P2), (C) patient 3 (P3), and (D) patient 5 (P5).
case_images: fimmu-13-885023-g001.jpg
case_images: PMC9039219_05_fimmu-13-885023-g001.jpg
case_images: f1
case_images: During the last 3 years, the patient complained of persisting severe itching and presented exclusively disseminated nodules ( Figure 1D ).
case_images: PMC9039219_03
case_images: Clinical manifestation of pemphigoid nodularis in the studied patients:disseminated nodules, excoriations, hyperpigmentation, and hypopigmentation in (A) patient 1 (P1), (B) patient 2 (P2), (C) patient 3 (P3), and (D) patient 5 (P5).
case_images: fimmu-13-885023-g001.jpg
case_images: PMC9039219_05_fimmu-13-885023-g001.jpg
case_images: f1
case_images: During the last 3 years, the patient complained of persisting severe itching and presented exclusively disseminated nodules ( Figure 1D ).
case_images: PMC9039219_04
case_images: Clinical and immunological features of patient 4 (P4): (A) gingivitis, (B) scarring conjunctivitis of the left eye, and (C) disseminated nodules located on the trunk. FOAM-LSCM of patient's oral mucosa: (D) linear IgG deposits (green color) localized below laminin-332 (red color) and (E) above collagen type IV (red color) at the BMZ.
case_images: fimmu-13-885023-g002.jpg
case_images: PMC9039219_04_fimmu-13-885023-g002.jpg
case_images: f2
case_images: A 67-year-old woman with type 2 diabetes, hypertension, asthma, and obesity was referred to our outpatient clinic 7 years ago with a 2-year history of extensive oral erosions on gingiva, palates, and buccal mucosa and single erosions on the trunk ( Figures 2A-C ). Overlay antigen mapping using laser scanning confocal microscopy disclosed IgG deposits below laminin 332 and above collagen type IV, typically for mucous membrane pemphigoid (MMP) ( Figures 2D, E ).
case_images: PMC9039219_05
case_images: Clinical manifestation of pemphigoid nodularis in the studied patients:disseminated nodules, excoriations, hyperpigmentation, and hypopigmentation in (A) patient 1 (P1), (B) patient 2 (P2), (C) patient 3 (P3), and (D) patient 5 (P5).
case_images: fimmu-13-885023-g001.jpg
case_images: PMC9039219_05_fimmu-13-885023-g001.jpg
case_images: f1
case_images: During the last 3 years, the patient complained of persisting severe itching and presented exclusively disseminated nodules ( Figure 1D ).