case_images: PMC10902430_01
case_images: Timeline of the patient's cancer treatment.
case_images: fonc-14-1332478-g001.jpg
case_images: PMC10902430_01_fonc-14-1332478-g001.jpg
case_images: f1
case_images: Figure 1 . Five days after his third infusion of EV, he presented to the emergency department with generalized weakness, diarrhea (up to 10 episodes per day), shortness of breath on exertion and at rest, fatigue, lethargy, and decreased food intake.
case_images: Timelines of insulin requirement, blood sugar level and CRRT (continuous renal replacement therapy).
case_images: fonc-14-1332478-g002.jpg
case_images: PMC10902430_01_fonc-14-1332478-g002.jpg
case_images: f2
case_images: He required a maximum rate of insulin drip 90 units/hour continuously for a total of 9 days until his glucose level reached <150 mg/dL and was then transitioned to regular insulin ( Figure 2 ). His glucose level was significantly improved after CRRT was initiated and it was continued for a total of 15 days ( Figure 2 ).
case_images: Histopathologic findings on skin biopsy.
case_images: fonc-14-1332478-g003.jpg
case_images: PMC10902430_01_fonc-14-1332478-g003.jpg
case_images: f3
case_images: A punch biopsy was obtained and pathology demonstrated a superficial dermatitis with increased apoptotic bodies and dyskeratotic cells, which could be compatible with a direct cytotoxic drug effect versus a non-specific drug reaction ( Figure 3 ).