case_images: PMC11380871_01
case_images: PMC11380871_02
case_images: Laboratory results of the patient at diagnosis. (A) Morphologic evaluation of bone marrow (Wright-Giemsa stain, x1000). (B) Flow cytometry results of bone marrow. (C) FISH results of PML-RARalpha in bone marrow. (D) Karyotype analysis results of bone marrow.
case_images: OTT-17-733-g0001.jpg
case_images: PMC11380871_02_OTT-17-733-g0001.jpg
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case_images: BM aspirates revealed a high percentage of abnormal promyelocytes, accounting for approximately 97% of the total nucleated cells [Figure 1A]. Flow cytometry showed the blasts (CD34+-CD11+HLA-DR-) co-expressed myeloid (myeloperoxidase, CD117, CD13, CD33, and CD64) and T-lineage (cytoplasmic CD3, and CD2) markers, suggestive of mixed-phenotype acute leukemia (MPAL), T/myeloid [Figure 1B]. Cytogenetic analysis showed an abnormal karyotype of 46,XX, t(15,17)(q24;q21) [Figure 1C and D].