case_images: PMC11835107_01
case_images: Preoperative electronic laryngoscopy. This image from an electronic laryngoscopy shows a smooth, well-defined nodular lesion on the right vocal cord, causing partial airway obstruction.
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case_images: PMC11835107_01_medi-104-e41574-g001.jpg
case_images: F1
case_images: Upon initial evaluation, an electronic laryngoscopy revealed a pale red, smooth neoplasm obstructing part of the vocal cords and obscuring the anterior commissure, affecting the mobility of the right vocal cord and impairing closure on both sides (Fig. 1).
case_images: Axial computed tomography (CT) scans of the larynx. This CT scan at the level of the vocal cords displays a well-defined mass in the right paraglottic space. The mass demonstrates homogeneous enhancement and is adjacent to but not invading the thyroid cartilage.
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case_images: F2
case_images: An enhanced neck computed tomography scan showed a mass involving the right vocal cord, anterior commissure, and adjacent paraglottic space, suggestive of a neoplastic lesion (Fig. 2).
case_images: PMC11835107_02
case_images: Postoperative pathological findings. This image shows a biopsy from the larynx stained with hematoxylin and eosin, displaying characteristic features of small cell neuroendocrine carcinoma. Notable is the densely packed small cells with high nuclear-to-cytoplasmic ratios and prominent mitotic figures, indicative of aggressive tumor behavior.
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case_images: PMC11835107_02_medi-104-e41574-g003.jpg
case_images: F3
case_images: Postoperative pathology confirmed the diagnosis of SCNEC of the larynx, supported by immunohistochemical findings: CD56(+), SYN(+), CgA(-), CK(focal+), CK5/6(-), CD45(-), Vimentin(-), p53(-), and Ki-67 proliferative index of 80% (Figs. 3 and 4).
case_images: Postoperative pathological findings. Immunohistochemistry staining for synaptophysin in the tumor tissue shows strong, diffuse cytoplasmic positivity, confirming the neuroendocrine origin of the carcinoma.
case_images: medi-104-e41574-g004.jpg
case_images: PMC11835107_02_medi-104-e41574-g004.jpg
case_images: F4
case_images: Postoperative pathology confirmed the diagnosis of SCNEC of the larynx, supported by immunohistochemical findings: CD56(+), SYN(+), CgA(-), CK(focal+), CK5/6(-), CD45(-), Vimentin(-), p53(-), and Ki-67 proliferative index of 80% (Figs. 3 and 4).