case_images: PMC5066988_01
case_images: CT images of the trachea and thyroid.. Notes: (A) A plain CT scan of the trachea shows tracheal compression and displacement. (B) The tumor did not invade the glottis. (C) A plain thyroid CT scan reveals multiple bilateral thyroid nodules. (D) An enhanced thyroid CT scan displays thyroid nodules that are enhanced slightly.. Abbreviations: CT, computed tomography; HU, Hounsfield units.
case_images: ott-9-6291Fig1.jpg
case_images: PMC5066988_01_ott-9-6291Fig1.jpg
case_images: f1-ott-9-6291
case_images: The subglottic tracheal wall was thickened (Figure 1A). The tumor did not invade the glottis (Figure 1B). The most prominent nodule was round and hypodense, and it was located in the right thyroid lobe (Figure 1C). The nodule measured 84 Hounsfield units (HU), unenhanced, and 95 HU with slight enhancement on a contrast-enhanced scan (Figure 1D).
case_images: Immunohistochemical staining findings.. Notes: (A) Frozen section analysis shows tumor cells in an irregular funicular distribution with invasive growth (100x). (B) The tumor infiltrates surrounding thyroid follicles in a cribriform and tubular distribution, and it is filled with slightly basophilic mucoid material consisting of a double-layer structure (hematoxylin and eosin staining, 100x). (C) Positive CK7 staining in glandular epithelial cells (100x). (D) Positive CD117 staining in glandular epithelial cells (100x). (E) Positive p40 staining in basal cells (100x). (F) Positive p63 staining in basal cells (100x).
case_images: ott-9-6291Fig2.jpg
case_images: PMC5066988_01_ott-9-6291Fig2.jpg
case_images: f2-ott-9-6291
case_images: Bilateral thyroid masses were resected, and frozen pathology was obtained, showing that both the masses were poorly differentiated carcinomas (Figure 2A). The cribriform structure was composed of differentially sized scattered or integrated smooth cellular islands, with a central, round space filled with slightly basophilic mucoid material (Figure 2B). Postoperative immunohistochemistry showed that the ductal epithelial cells were positive for pan-cytokeratin (CK), CK7 (Figure 2C), and CD117 (Figure 2D). The myoepithelial cells were positive for vimentin, S-100, P40 (Figure 2E), and P63 (Figure 2F).