case_images: PMC3227273_01
case_images: Radiographs of the patient's right femur: (a) preoperative, an expanding lytic lesion (10 cm in max. diameter) located in the right proximal femur with extension into the proximal shaft, (b) two months after limb salvage surgery followed by endoprosthetic replacement.
case_images: CRIM2011-980257.001.jpg
case_images: PMC3227273_01_CRIM2011-980257.001.jpg
case_images: fig1
case_images: X-rays and MRI presented an expanding 10 cm lytic lesion with an inhomogeneous contrast medium enhancement occupying the right proximal femur and extended into the proximal shaft (Figure 1). The patient underwent limb salvage surgery followed by endoprosthetic replacement (Figure 1).
case_images: The explant shows a proximal femur measured 25 cm in length, a tumor of 10 cm in max. dimension and predominantly grey-white appearance occupies the medullary cavity.
case_images: CRIM2011-980257.002.jpg
case_images: PMC3227273_01_CRIM2011-980257.002.jpg
case_images: fig2
case_images: The explant consisted of a 25 cm long proximal femur (Figure 2) with a 10 cm tumor in largest diameter that mainly occupied the medullary cavity. The tumor showed a grey-white cutting surface (Figure 2). 
case_images: Histologic workup of the tumor tissue: (a) HE, (b) HE, (c) SMA, (d) Desmin.
case_images: CRIM2011-980257.003.jpg
case_images: PMC3227273_01_CRIM2011-980257.003.jpg
case_images: fig3
case_images: The tumor cells were spindle shaped, elongated, blunt ended, hyperchromatic, focally pleomorphic, and surrounded by a prominent eosinophilic cytoplasm (Figure 3). Immunohistochemistry using antibodies directed against Cytokeratin and S-100 were negative (Figure 3).