case_images: PMC9149489_01
case_images: Motor nerve conduction studies (Median nerve/APB) from a normal subject (a) and a patient with IgM paraproteinaemic polyneuropathy and anti-MAG antibodies (b). Abnormalities demonstrated in B are reduced motor amplitude; severe prolongation of the distal motor latency (from wrist stimulation to the muscle); and mild slowing of the motor conduction velocity (wrist to elbow), indicating predominantly distal slowing, characteristic of the disorder.
case_images: crn-0014-0213-g01.jpg
case_images: PMC9149489_01_crn-0014-0213-g01.jpg
case_images: F1
case_images: These findings were diagnostic of WM (lymphoplasmacytic lymphoma) with suspected related sensorimotor neuropathy (shown in Fig. 1).
case_images: Axial MRI scans demonstrating lesions suggestive of malignant tumour with surrounding vasogenic oedema (T2 weighted images - Cases 1 and 2; gadolinium-enhanced T1-weighted image - Case 3).
case_images: crn-0014-0213-g02.jpg
case_images: PMC9149489_03_crn-0014-0213-g02.jpg
case_images: F2
case_images: MRI demonstrated an enhancing lesion in the right frontal lobe, suggestive of a malignant neoplasm (shown in Fig. 2).
case_images: Biopsies from all 3 patients showed features of Glioblastoma, IDH-wildtype (WHO grade IV) with pleomorphic astrocytic cells, mitotic activity, microvascular proliferation (Case 1) and necrosis (Cases 2 and 3). In each case, the cell proliferation index assessed by ki67 immunohistochemistry was high. IDH1 was assessed as nonmutated by lack of staining for the common IDH-1 (R132H) mutation specific antibody.
case_images: crn-0014-0213-g03.jpg
case_images: PMC9149489_03_crn-0014-0213-g03.jpg
case_images: F3
case_images: The patient underwent a craniotomy for partial debulking, with histological analysis confirming glioblastoma IDH-wildtype (WHO grade IV) with GFAP immunoreactivity, lack of staining for IDH1 (R132H), retained ATRX and a high Ki67 proliferation index (shown in Fig. 3).
case_images: PMC9149489_02
case_images: Axial MRI scans demonstrating lesions suggestive of malignant tumour with surrounding vasogenic oedema (T2 weighted images - Cases 1 and 2; gadolinium-enhanced T1-weighted image - Case 3).
case_images: crn-0014-0213-g02.jpg
case_images: PMC9149489_03_crn-0014-0213-g02.jpg
case_images: F2
case_images: MRI demonstrated an enhancing lesion in the right frontal lobe, suggestive of a malignant neoplasm (shown in Fig. 2).
case_images: Biopsies from all 3 patients showed features of Glioblastoma, IDH-wildtype (WHO grade IV) with pleomorphic astrocytic cells, mitotic activity, microvascular proliferation (Case 1) and necrosis (Cases 2 and 3). In each case, the cell proliferation index assessed by ki67 immunohistochemistry was high. IDH1 was assessed as nonmutated by lack of staining for the common IDH-1 (R132H) mutation specific antibody.
case_images: crn-0014-0213-g03.jpg
case_images: PMC9149489_03_crn-0014-0213-g03.jpg
case_images: F3
case_images: The patient underwent a craniotomy for partial debulking, with histological analysis confirming glioblastoma IDH-wildtype (WHO grade IV) with GFAP immunoreactivity, lack of staining for IDH1 (R132H), retained ATRX and a high Ki67 proliferation index (shown in Fig. 3).
case_images: PMC9149489_03
case_images: Axial MRI scans demonstrating lesions suggestive of malignant tumour with surrounding vasogenic oedema (T2 weighted images - Cases 1 and 2; gadolinium-enhanced T1-weighted image - Case 3).
case_images: crn-0014-0213-g02.jpg
case_images: PMC9149489_03_crn-0014-0213-g02.jpg
case_images: F2
case_images: MRI demonstrated an enhancing lesion in the right frontal lobe, suggestive of a malignant neoplasm (shown in Fig. 2).
case_images: Biopsies from all 3 patients showed features of Glioblastoma, IDH-wildtype (WHO grade IV) with pleomorphic astrocytic cells, mitotic activity, microvascular proliferation (Case 1) and necrosis (Cases 2 and 3). In each case, the cell proliferation index assessed by ki67 immunohistochemistry was high. IDH1 was assessed as nonmutated by lack of staining for the common IDH-1 (R132H) mutation specific antibody.
case_images: crn-0014-0213-g03.jpg
case_images: PMC9149489_03_crn-0014-0213-g03.jpg
case_images: F3
case_images: The patient underwent a craniotomy for partial debulking, with histological analysis confirming glioblastoma IDH-wildtype (WHO grade IV) with GFAP immunoreactivity, lack of staining for IDH1 (R132H), retained ATRX and a high Ki67 proliferation index (shown in Fig. 3).