case_images: PMC10102472_01
case_images: Contrast-enhanced abdominal CT (A-C) scan showed volumetric disproportion of lobar and segmental of the slightly enlarged liver with massive abdominal-pelvic fluid accumulation. Full-body PET-CT scan (D-F) showed no significant hypermetabolism but a slightly low signal from the subcapsular area in the right hepatic lobe with ascites and splenomegaly. Red arrows point to the subcapsular area in the right hepatic lobe with ascites.
case_images: fonc-13-1145540-g001.jpg
case_images: PMC10102472_01_fonc-13-1145540-g001.jpg
case_images: f1
case_images: Figure 1 ). Further full-body PET-CT images correspond to contrast-enhanced abdominal CT and disclosed no significant hypermetabolism (shown in  Figure 1 ).
case_images: Cells from ascites were centrifuged and then stained. (A, B) Heterogeneous lymphoid-like cells were distributed in a scattered pattern, hematoxylin-eosin staining in A, papanicolaou staining in B, magnification x100. (C-E) Ascites cells were positive for CD20, CD79alpha, LCA, magnification x100. (F) FISH analysis revealed that 20%-30% of the ascites cells exhibited c-MYC amplification, magnification x100.
case_images: fonc-13-1145540-g002.jpg
case_images: PMC10102472_01_fonc-13-1145540-g002.jpg
case_images: f2
case_images: Histology suggested that the ascites puncture cytology contained aggressive of large-sized B lymphocytes positive for CD20, CD79alpha, LCA, c-MYC (shown in  Figure 2 ), and other biomarkers, such as PAX5(+), CD3(+), CD19(+), CD34(-), HHV8(-), Ki-67(+, 60%), BCL-6(+), MUM1(-), sox11(-), EMA(-), and MPO(+) consistent with the result of the immunohistochemical staining of bone marrow biopsy, which presented CD20(+), CD79alpha(+), CD3(+), BCL-6(-), MPO(+) (shown in  Figure 3 ), CD10(-), Ki-67(+, 1%<), and MUM(-).