case_images: PMC3656690_01
case_images: a Skin lesions in patient 1 which consisted of maculopapular rash with ulcerations and edema at lower leg and foot before treament. b After treatment with rituximab.
case_images: cde-0005-0115-g01.jpg
case_images: PMC3656690_01_cde-0005-0115-g01.jpg
case_images: F1
case_images: Lower extremities showed bilateral maculopapular rash with ulcerations and livida reticularis (fig. 1).
case_images: Photomicrograph of a section of skin in patient 1, showing dilated subepidermal small vessels with swollen endothelial cells. There is a perivascular infiltrate consisting mainly of lymphocytes, few plasma cells and extravasated erythrocytes of which some are fragmented. No vascular necrosis is seen (HE, x200).
case_images: cde-0005-0115-g02.jpg
case_images: PMC3656690_01_cde-0005-0115-g02.jpg
case_images: F2
case_images: Skin biopsy showed leukocytoclastic vasculitis with predominantly lymphocytic infiltrate in the subepidermal layer only with extravasated fragmented erythrocytes indicating vascular leaks (fig. 2).
case_images: PMC3656690_02