case_images: PMC8313374_01
case_images: (A) Chest CT detected a 13x4 mm nodule in the right upper lung; (B) abdominal MRI revealed a perirenal tumor, 18x28 mm in size, close to the hilum of the left kidney.
case_images: OTT-14-4255-g0001.jpg
case_images: PMC8313374_01_OTT-14-4255-g0001.jpg
case_images: f0001
case_images: A 43-year-old man presented to the department of thoracic surgery with a 13x4 mm nodule in the right upper lung detected by computed tomography (CT) during examination (Figure 1A). Furthermore, a perirenal mass, 18x28 mm in size, close to the hilum of the left kidney was found through abdominal magnetic resonance imaging (MRI) (Figure 1B). Figure 1A and B). Furthermore, immunohistochemical stains showed that this lesion was C-MET (+) and ROS1 (+) (Supplementary Figure 1C and D). Considering the patient's physical condition, he went home for two months after the first operation and was then admitted to our hospital for retroperitoneal neoplasm.
case_images: Positron emission tomography (PET)-CT whole body imaging. (A) A 15x10 mm shadow with ground glass density in the upper right lung was detected; (B) a neoplastic lesion with hypermetabolism close to the left renal hilum was shown.
case_images: OTT-14-4255-g0002.jpg
case_images: PMC8313374_01_OTT-14-4255-g0002.jpg
case_images: f0002
case_images: Positron emission tomography-computed tomography (PET-CT) showed lesions in both the lung and the renal hilum (Figure 2A and B), which suggested neoplastic lesions. Histologically, the tumor was composed of cells with eosinophilic cytoplasm with moderate epithelioid appearance (Supplementary Figure 2A-D).
case_images: Immunohistochemistry of the perirenal mass showed positive for Melan-A, cluster differentiation (CD)56, and TFE3, while negative for HMB45, Syn, S-100 and SOX10. Ki67 was present in approximately 1% of tumor cells.
case_images: OTT-14-4255-g0003.jpg
case_images: PMC8313374_01_OTT-14-4255-g0003.jpg
case_images: f0003
case_images: In addition, Ki67 was present in approximately 1% of tumor cells (Figure 3).