case_images: PMC4333547_01
case_images: Hyperplastic epidermis and upper dermal well-circumscribed cystic lesion formed entirely of homogenous basophilic deposits (H and E, x100)
case_images: OJO-8-56-g001.jpg
case_images: PMC4333547_01_OJO-8-56-g001.jpg
case_images: F1
case_images: Histopathological examination of the nodule showed hyperplastic epidermis and upper dermal well-circumscribed focally cystic lesion [Figure 1].
case_images: (a) Variable shaped and sized large amorphous basophilic deposits (H and E, x200). (b) Closer view of calcification at dermis and epidermis (H and E, x400)
case_images: OJO-8-56-g002.jpg
case_images: PMC4333547_01_OJO-8-56-g002.jpg
case_images: F2
case_images: It is formed of homogenous basophilic deposits variable in shape and size ranging from large amorphous deposits, small spherules to minute fine granules [Figures 2-4] that consistent with subepidermal calcified nodule (SCN) as a variant calcinosis cutis.
case_images: (a) Large amorphous basophilic deposits, (b) Myriads of minute fine basophilic granules (H and E, x400)
case_images: OJO-8-56-g003.jpg
case_images: PMC4333547_01_OJO-8-56-g003.jpg
case_images: F3
case_images: It is formed of homogenous basophilic deposits variable in shape and size ranging from large amorphous deposits, small spherules to minute fine granules [Figures 2-4] that consistent with subepidermal calcified nodule (SCN) as a variant calcinosis cutis.
case_images: Calcifications ranged from large amorphous deposits (black arrows), well-formed small spherules (green circles) to small fine granules (brown arrows) (H and E, x400)
case_images: OJO-8-56-g004.jpg
case_images: PMC4333547_01_OJO-8-56-g004.jpg
case_images: F4
case_images: It is formed of homogenous basophilic deposits variable in shape and size ranging from large amorphous deposits, small spherules to minute fine granules [Figures 2-4] that consistent with subepidermal calcified nodule (SCN) as a variant calcinosis cutis.
case_images: (a) Black calcium deposits with three forms of calcification, (b) Predominance of large amorphous calcium, (c) and the predominance of minute fine granules (Von kossa stain, x400)
case_images: OJO-8-56-g005.jpg
case_images: PMC4333547_01_OJO-8-56-g005.jpg
case_images: F5
case_images: This diagnosis is confirmed by Von kossa stain that identifies the calcium in tissues as black deposits within pink background [Figure 5].