case_images: PMC10026180_01
case_images: Multiple well demarcated, punched-out, ulcers with erythematous indurated borders, with fibrin on their base and an overlying hemorrhagic crust, on the lower leg of a 13.5-year-old boy with a combined immunodeficiency syndrome, consistent with varicella-zoster virus infection overlying chronic ulcerative granulomas.
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case_images: PMC10026180_01_fped-11-1103726-g001.jpg
case_images: F1
case_images: PMC10026180_02
case_images: Hemorrhagic vesicle with a necrotic center on the arm of an 11-year-old girl with CVID, consistent with varicella-zoster virus infection. CVID, common variable immunodeficiency.
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case_images: PMC10026180_02_fped-11-1103726-g002.jpg
case_images: F2
case_images: At age 11, she presented with hemorrhagic vesicles on her trunk and extremities, with a necrotic center (Figure 2).
case_images: PMC10026180_03
case_images: Erythematous plaques with diffuse yellow thick scale and hemorrhagic crusts on the feed (A) and hand (B) of a 3-year-old boy with MALT1 deficiency, consistent with Norwegian scabies.
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case_images: F3
case_images: Rash recurred and progressed to thick hyperkeratotic plaques on the extremities, palms, and soles (Figure 3A,B).
case_images: PMC10026180_04
case_images: An erythematous plaque with a central erosion, circinate-elevated border, overlying pustules, and purulent discharge on the tip of the nose of a 10.5-year-old girl with AT. Small satellite papules were also present on the nostrils, consistent with a fungal infection. AT, ataxia telangiectasia.
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case_images: F4
case_images: The nose bridge and nostrils had small erythematous erosions (Figure 4).
case_images: PMC10026180_05
case_images: Widespread ulceration on the buttocks and scrotum with a central black eschar in their center and yellow-green exudate in a 5-month-old girl with DOCK8 deficiency, consistent with Candida and Pseudomonas infection.
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case_images: PMC10026180_05_fped-11-1103726-g005.jpg
case_images: F5
case_images: Ulcers on the thigh had black eschars in their center, and on the buttocks, the ulcers had green exudate (Figure 5).
case_images: PMC10026180_06
case_images: Diffuse widespread pink-gray verrucous exophytic papules and plaques on the perianal and perigenital regions of a 14-year-old boy with X-linked SCID, consistent with condyloma acuminata. SCID, severe combined immunodeficiency.
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case_images: PMC10026180_06_fped-11-1103726-g006.jpg
case_images: F6
case_images: First, they appeared on only one finger but then spread to the other fingers and the perianal area, genitals, and face (Figure 6).
case_images: PMC10026180_07
case_images: Diffuse pink-gray verrucose papules on the perianal area of a 1.5-year-old boy with CARD11 deficiency, consistent with condyloma acuminata. CARD11, caspase activation and recruitment domain family member 11.
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case_images: PMC10026180_07_fped-11-1103726-g007.jpg
case_images: F7
case_images: At 1 year and 9 months of age, the patient had verrucose exophytic papules and plaques on the perianal area, with gradual growth and outward expansion to the surrounding skin (Figure 7).
case_images: PMC10026180_08
case_images: (A) Erythematous papulonodular eruption on the buttocks, lower back, and hip with scale and hemorrhagic crusts in a 10-month-old boy with X-linked CGD, consistent with molluscum contagiosum. (B) Post-treatment with IV cidofovir and a resolution of the lesions with the remaining postinflammatory changes and mild scarring. CGD, chronic granulomatous disease.
case_images: fped-11-1103726-g008.jpg
case_images: PMC10026180_08_fped-11-1103726-g008.jpg
case_images: F8
case_images: At 10 months of age, the patient presented with erythematous papules and nodules on the buttocks, which spread to the inguinal areas and his back (Figure 8A).