case_images: PMC5066990_01
case_images: PMC5066990_02
case_images: PMC5066990_03
case_images: Computed tomography scan of case 3.. Note: An irregular mass with a clear border, uneven density, and heterogeneous enhancement is visible.
case_images: ott-9-6171Fig1.jpg
case_images: PMC5066990_03_ott-9-6171Fig1.jpg
case_images: f1-ott-9-6171
case_images: Radiological investigations revealed a mediastinal mass measuring 8 cm in its largest dimension (Figure 1).
case_images: Pathological results from an atypical thymic carcinoid.. Notes: A section of the mass from case 3 was observed under a light microscope (Olympus BX51; Olympus Corporation, Tokyo, Japan) after hematoxylin-eosin staining. Original magnification x100.
case_images: ott-9-6171Fig2.jpg
case_images: PMC5066990_03_ott-9-6171Fig2.jpg
case_images: f2-ott-9-6171
case_images: Hematoxylin-eosin staining demonstrated that the tumor cells were arranged in a nested, trabecular, or pseudorosette pattern, with mild atypia and homogeneous staining in nuclei and chromatin in all three cases (Figure 2).
case_images: Immunohistochemistry results from an atypical thymic carcinoid.. Notes: Immunohistochemistry analysis of a tumor sample from case 3 demonstrating positive detection of CD56, CAM5.2, CgA, CK, and Syn (A-E, respectively). The staining index for Ki-67 (F) was between 5% and 20%. Magnification x100.
case_images: ott-9-6171Fig3.jpg
case_images: PMC5066990_03_ott-9-6171Fig3.jpg
case_images: f3-ott-9-6171
case_images: Immunohistochemistry of tumor samples of the three cases demonstrated positivity for CD56, CAM5.2, CgA, CK, and Syn (Figure 3A-E), and staining indices for Ki-67 of between 5% and 20% (Figure 3F).