case_images: PMC10914379_01
case_images: a Pathological tibial fracture due to a permeative lytic lesion coupled with cortical disruption. b Displaced left humeral fracture.
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case_images: F1
case_images: Imaging showed a permeative lytic lesion in the left tibia coupled with cortical disruption (Fig. 1a). It also showed a displaced left humeral fracture (Fig. 1b) along with multiple lytic lesions and compression fractures in the spine.
case_images: a Bone marrow infiltration by neoplastic plasma cells. Hematoxylin and eosin staining. Objective x60. b Plasma cells expressing bright cytoplasmic CD138 expression. c Lambda light chain restriction. Objective x40.
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case_images: F2
case_images: Bone marrow examination showed 40% neoplastic plasma cells in the bone marrow (Fig. 2a), positive for CD138 (Fig. 2b), CD 45/38/81/56, with lambda light chain restriction (Fig. 2c) and negative for CD 20/19/79b/PAX-5.
case_images: Time course of anti-myeloma therapies. Ld, lenalidomide/dexamethasone; ZOL; zoledronic acid; DVd, daratumumab/bortezomib/dexamethasone; PCd, pomalidomide/cyclophosphamide/dexamethasone.
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case_images: PMC10914379_01_cro-2024-0017-0001-536675_F03.jpg
case_images: F3
case_images: Her previous therapy is shown in Figure 3.
case_images: a Atypical plasmacytoid cells, involving soft tissue. Hematoxylin and eosin staining. Objective x60. b Plasma cells expressing bright cytoplasmic CD138 expression. Objective x60. c Plasmacytoma cell showing lambda light chain restriction. Objective x40.
case_images: cro-2024-0017-0001-536675_F04.jpg
case_images: PMC10914379_01_cro-2024-0017-0001-536675_F04.jpg
case_images: F4
case_images: Microscopic examination showed atypical plasmacytoid cells, involving soft tissue (Fig. 4a). CD138 (Fig. 4b), CD 45/38/81/56, and FLC lambda restriction (Fig. 4c). Cells were negative for CD 20/19/79 and EBV.