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case_images: Allergy symptoms developed in 2021 by female researcher (F-Res) when weighing out HBTU and/or dissolving it under the fume hood. (A) The first brush with allergy-induced lip swelling less than an hour of exposure to HBTU. (B,C) Typical skin rushes appeared around her mouth and on her cheeks (B) and in the neck crease (C) starting from the second allergic event. (D-F) The progression of skin rushes 1 week after exposure.
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case_images: This irritation initially presented as reddened skin but quickly progressed to a rash with irritated, swollen skin, and itchy, painful lesions (Figure 2). After 6 months, she noticed a mild skin irritation around her mouth (Figure 2A,B) but did not associate it with the use of HBTU. Almost immediately, F-Res started to develop skin irritation, which became progressively more severe with each exposure (Figure 2).
case_images: Allergy symptoms developed in 2022 by female researcher (F-Res) when exposed to HBTU solution. (A-C) Lesions appeared on her neck crease less than 1 day after exposure (A,B) and after 10 days (C). (D-F) Allergically induced eye swelling after 12 h (D) and progressed over 3 days (E,F).
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case_images: After 8-10 h, her eyes were swollen, and she had lesions around her mouth and neck crease (Figure 3).
case_images: Allergy symptoms developed during the next 24 h after exposure in 2023 by female researcher (F-Res) only by entering in the laboratory where a coworker was using HBTU under the fume hood.
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