case_images: PMC11239438_01
case_images: Patient glucose levels, age 70-78. Graph of patient glucose (mg/dl-milligrams per deciliter).
case_images: fpsyt-15-1326702-g001.jpg
case_images: PMC11239438_01_fpsyt-15-1326702-g001.jpg
case_images: f1
case_images: By 2013, EJ was hyperglycemic; his glucose levels were frequently over the normal range of 100-125 mg/dL (,  Figure 1 ), and fluctuated at the 125-230 range with a median score of 142 mg/dL (ages 70-78).
case_images: Patient HbA1c score and patient status history.
case_images: fpsyt-15-1326702-g002.jpg
case_images: PMC11239438_01_fpsyt-15-1326702-g002.jpg
case_images: f2
case_images: Subsequent HbA1c scores revealed his pre-diabetic status ( Figure 2 , patient medical records) 4  ,  5 . As  Figure 2  shows, EJ persisted for two years and 5 months in expressing to neurologist (#1) his "decreased memory" (5/31/18), "concerns and changes with [his] memory" (1/29/19), "memory decline" which his wife also linked to his reduced focus and attentional abilities (4/30/19), and finally "possible dementia" (10/12/20) before his formal MCI diagnosis.
case_images: Temporal lobe ventricles change in grey matter volume between baseline and treatment month 9 (cross-sectional view). Left image: Treatment baseline (6/21/21). Right image: After 9 months of treatment (3/11/22).
case_images: fpsyt-15-1326702-g003.jpg
case_images: PMC11239438_01_fpsyt-15-1326702-g003.jpg
case_images: f3
case_images: The new treating neurologist (#2) diagnosed EJ with IR/T2DM due to his HbA1c test (5.9, Borderline High, 7/22/21), 5  long-standing hyperglycemia (glucose levels, 145 mg/dL (7/22/21), Baseline MCI Screen ( Figure 3A , 6/15/21, Below Normal, Section 4.1.10) and Baseline MRI (6/21/21, 1 single small stroke [lacunar infarct]). EJ's MRI (6/21/21) also showed abnormal grey matter volume [GMV] loss at the tips of the temporal lobes ( Figure 3A , Sec. 4.1.10.).