case_images: PMC10939184_01
case_images: A - Gross view of the cut surface of the yellow to orange ovary with areas of hemorrhage; B - Frozen section: showing the sheets of tumor cells having round to oval monomorphic nuclei and abundant eosinophilic to vacuolated cytoplasm (H&E, 40x); C - Paraffin section: showing sheets and clusters of tumor cells with scant intervening stroma (H&E, 10x); D - Paraffin section: Cells are polyhedral having central nuclei, prominent nucleoli and abundant eosinophilic to clear multivacuolated cytoplasm (H&E, 40x).
case_images: autopsy-14-e2024478-g01.jpg
case_images: PMC10939184_01_autopsy-14-e2024478-g01.jpg
case_images: gf01
case_images: The frozen section of the oophorectomy showed a benign sex cord-stromal tumor (Figures 1B and 1C). Notably, there were no indications of nuclear atypia or mitotic activity, suggesting a relatively benign nature of the tumor (Figure 1D). 
case_images: Photomicrographs of the tumor. A, B, and C - Immunohistochemistry diffuse nuclear and cytoplasmic staining for calretinin, Diffuse granular cytoplasmic staining for Inhibin, focal Granular cytoplasmic staining for Melan A (40X). D - Immunohistochemistry is negative for Cytokeratin (40x).
case_images: autopsy-14-e2024478-g02.jpg
case_images: PMC10939184_01_autopsy-14-e2024478-g02.jpg
case_images: gf02
case_images: Immunohistochemistry was performed, and the results showed immunoreactivity for inhibin, calretinin, and Melan-A. (Figure 2A, 2B, 2C) Additionally, there was patchy immunoreactivity for vimentin. Notably, there was no reactivity observed for Pan CK (pan-cytokeratin) (Figure 2D) and PAX8, which collectively supported the diagnosis of an ovarian steroid cell tumor classified as "Not Otherwise Specified" (NOS). 