case_images: PMC7728125_01
case_images: Hematoxylin-Eosin (HE) staining (x100) shows the histological features of angiosarcoma, with normal tissue of the thyroid gland in the peripheral edge and areas with large epithelioid cells.
case_images: RJME-61-1-267-fig1.jpg
case_images: PMC7728125_01_RJME-61-1-267-fig1.jpg
case_images: F1
case_images: The histopathological (HP) assessment showed malignant proliferation characterized by epithelioid, large rounded cells with relatively high nuclear grade (Figure 1).
case_images: HE staining (x200) highlights tumor cells with eosinophilic cytoplasm and large, vesicular nuclei with prominent nucleoli. Numerous atypical mitoses are present
case_images: RJME-61-1-267-fig2.jpg
case_images: PMC7728125_01_RJME-61-1-267-fig2.jpg
case_images: F2
case_images: Atypical mitoses were present (Figure 2).
case_images: HE staining (x400) shows numerous vascular channels bordered by the epithelioid cells
case_images: RJME-61-1-267-fig3.jpg
case_images: PMC7728125_01_RJME-61-1-267-fig3.jpg
case_images: F3
case_images: Moreover, the cells grow in sheets and lined abnormal vascular spaces that contained erythrocytes (Figures 3 and 4).
case_images: Silver staining (x200) shows the vasoformation architecture
case_images: RJME-61-1-267-fig4.jpg
case_images: PMC7728125_01_RJME-61-1-267-fig4.jpg
case_images: F4
case_images: Moreover, the cells grow in sheets and lined abnormal vascular spaces that contained erythrocytes (Figures 3 and 4).
case_images: Immunohistochemical staining (x100) shows strong diffuse immunoreactivity for anti-CD31 antibody. CD31: Cluster of differentiation 31
case_images: RJME-61-1-267-fig5.jpg
case_images: PMC7728125_01_RJME-61-1-267-fig5.jpg
case_images: F5
case_images: Regarding the immunohistochemical profile, the neoplastic cells were strongly positive for CD31 (Figure 5), erythroblast transformation-specific related gene (ERG) (Figure 6) and CD34.
case_images: Immunohistochemical staining (x100) shows strong immunoreactivity for anti-ERG antibody. ERG: Erythroblast transformation-specific related gene
case_images: RJME-61-1-267-fig6.jpg
case_images: PMC7728125_01_RJME-61-1-267-fig6.jpg
case_images: F6
case_images: Regarding the immunohistochemical profile, the neoplastic cells were strongly positive for CD31 (Figure 5), erythroblast transformation-specific related gene (ERG) (Figure 6) and CD34.