case_images: PMC3623783_01
case_images: Generalized exanthematous rash on the trunk and extremities of our patient.
case_images: 1752-1947-7-34-1.jpg
case_images: PMC3623783_01_1752-1947-7-34-1.jpg
case_images: F1
case_images: After two weeks of anti-tuberculosis medication, a generalized exanthematous rash appeared on his trunk and extremities (Figure 1).
case_images: Multiple, well-defined, non-blanchable, erythematous macules and papules in an annular arrangement.
case_images: 1752-1947-7-34-2.jpg
case_images: PMC3623783_01_1752-1947-7-34-2.jpg
case_images: F2
case_images: One day later, multiple well-defined, non-blanchable, erythematous-to-purplish macules and papules, some of which showed an annular arrangement, were noticed (Figure 2).
case_images: Histology of a purpuric annular lesion on our patient's leg.
case_images: 1752-1947-7-34-3.jpg
case_images: PMC3623783_01_1752-1947-7-34-3.jpg
case_images: F3
case_images: A skin biopsy from a purpuric annular lesion on his leg showed peri-vascular and interstitial infiltration of neutrophils with extravasation of erythrocytes and fibrin deposition (Figure 3), characteristic of LCV.
case_images: Direct immunofluorescence revealed positive IgA, IgM and C3 results along superficial dermal blood vessels.
case_images: 1752-1947-7-34-4.jpg
case_images: PMC3623783_01_1752-1947-7-34-4.jpg
case_images: F4
case_images: A direct immunofluorescence (DIF) study was positive for IgA, IgM and C3 along superficial dermal blood vessels, consistent with cutaneous small vessel vasculitis (Figure 4).