case_images: PMC10915776_01
case_images: Timeline displaying the evolution of this case: in the white boxes, the date has been reported; in the blue boxes is a list of the important events that have been performed; in the green boxes, we have displayed the therapies; and in the black boxes, the evaluation was conducted, MRI, magnetic resonance imaging; Methyl-PD, methylprednisolone; MMSE, Mini-mental stare examination.
case_images: fneur-15-1340284-g001.jpg
case_images: PMC10915776_01_fneur-15-1340284-g001.jpg
case_images: fig1
case_images: Electroencephalogram, Immunofluorescence, and MRI results. (A) Electroencephalogram revealed a fundamental rhythm with a small amount of low-amplitude alpha (7-14 Hz) and theta activity (4-7 Hz). (B) Immunofluorescence of Serum anti-IgLON5 antibody (1:1,000). (C) Immunofluorescence of CSF anti-IgLON5 antibody (1:100). (D-F) Brain MRI-DWI showed symmetrical high signal intensity in the both sides of the centrum semiovale (arrowhead). (D) 2023.03.27; (E) 2023.04.03; (F) 2023.05.16. MRI, magnetic resonance imaging; DWI, diffusion-weighted; CSF, cerebrospinal fluid.
case_images: fneur-15-1340284-g002.jpg
case_images: PMC10915776_01_fneur-15-1340284-g002.jpg
case_images: fig2
case_images: Cerebral diffusion-weighted magnetic resonance imaging (MRI-DWI) revealed hyperintensities in both sides of the centrum semiovale (Figures 2D-F). Electroencephalogram revealed a fundamental beta rhythm with a small amount of low-amplitude alpha (7-14 Hz) and theta activity (4-7 Hz; Figure 2A). Figures 2B,C), while other autoantibodies (Ri, Yo, Hu, malforming-A1, malforming-A2, N-methyl-D-aspartate receptor, alpha-amino-3:hydroxy-5-methyl-4-isoxazole propionic acid receptor, contactin-associated protein receptor 2, leucine rich glioma-inactivated protein 1, gamma-amino butyric acid type B receptor, dipeptidyl-peptidase-like protein 6, glyoxylate reductase 1, metabotropic glutamate receptor 5) was negative. For economic reasons, our patient refused the genetic test, a very helpful evaluation for anti-IgLON5 disease.