case_images: PMC11650303_01
case_images: A and B, Clinical pictures on the face and hands. C, A skin biopsy was taken in a spindle shape from the black-marked area on the dorsum of the right hand. D, Hematoxylin and eosin (H & E) stain, x200. E, CD3 stain, x200. F, CD8 stain, x200.
case_images: gr1.jpg
case_images: PMC11650303_01_gr1.jpg
case_images: fig1
case_images: A and B). A skin biopsy from the red-purple plaque on the dorsum of the right hand (Fig 1, C) indicated superficial perivascular dermatitis with hyperkeratosis and parakeratosis, lacking nuclear atypia of infiltrating lymphocytes (Fig 1, D). Immunohistochemically, a majority of immune cells tested positive for CD3, predominantly comprising CD8+ lymphocytes (Fig 1, E and F).
case_images: A, Clinical picture of erythematous eruption on his back. B, High power view on the back. A skin biopsy was performed in a spindle shape from the black-marked area on the back. C, H & E stain, x100. D, H & E stain, x200. E, CD3 stain, x200. F, CCR4 stain, x200. G, CT image. Arrows indicate enlarged axillary lymph nodes. CT, Computerized tomography.
case_images: gr2.jpg
case_images: PMC11650303_01_gr2.jpg
case_images: fig2
case_images: A). A skin biopsy from the back disclosed infiltration of atypical lymphocytes in the subcutaneous tissue (Fig 2, B-D). Immunohistochemically, a majority of the cells tested positive for CD3, and most CD3+cells were found to be CCR4 positive (Fig 2, E and F). Six months from the initial examination, abnormal lymphocytes emerged in the peripheral blood, coinciding with the CT image revealing the presence of enlarged axillary lymph nodes (Fig 2, G).