case_images: PMC5470565_01
case_images: - Photomicrography of the biopsied specimen (mammary tissue). A - Well-differentiated carcinoma infiltrating the mammary parenchyma (HE, 100X). B - In detail: note the cellular pattern arrangement and the scarcity of mitotic figures (HE, 400X).
case_images: autopsy-04-01053-g01.jpg
case_images: PMC5470565_01_autopsy-04-01053-g01.jpg
case_images: g01
case_images: The histological examination revealed a well-differentiated carcinoma infiltrating the mammary parenchyma, with peripheral microcalcifications, but an absence of the in situ component (Figure 1).
case_images: - Photomicrography of the biopsied specimen (mammary tissue). Immunohistochemical preliminary workup. A - Negative for the nuclear estrogenic receptor (200X). B - Negative for the nuclear progesterone receptor (400X). C - Negative for cEBR (HER2) (400X). D - Proliferative index below 5% (Ki67) (400X).
case_images: autopsy-04-01053-g02.jpg
case_images: PMC5470565_01_autopsy-04-01053-g02.jpg
case_images: g02
case_images: - Photomicrography of the biopsied specimen (mammary tissue). Complementary immunohistochemical workup. A - Chromogranin positive. B - Calcitonin positive.
case_images: autopsy-04-01053-g03.jpg
case_images: PMC5470565_01_autopsy-04-01053-g03.jpg
case_images: g03
case_images: In the light of these histological findings and additional clinical information, a new immunohistochemical panel was tested, which showed positive for chromogranin and calcitonin (Figure 3).