case_images: PMC10624942_01
case_images: Polypoid lesion noted in sigmoid colon of a 58-year-old Saudi man during screening colonoscopy. The polyp was removed by hot snare polypectomy with no immediate complications and subjected to laboratory analysis.
case_images: crg-2023-0017-0001-533550_F01.jpg
case_images: PMC10624942_01_crg-2023-0017-0001-533550_F01.jpg
case_images: F1
case_images: A small, 8-mm polypoid lesion was noted in sigmoid colon (Fig. 1).
case_images: a Tissue section showing unremarkable colonic mucosa with underlying well-circumscribed submucosal lesion. b The lesion comprised intersecting fascicles of monotonous spindle cells with eosinophilic cytoplasm and indistinct borders.
case_images: crg-2023-0017-0001-533550_F02.jpg
case_images: PMC10624942_01_crg-2023-0017-0001-533550_F02.jpg
case_images: F2
case_images: Pathology study showed an unremarkable colonic mucosa with underlying well-circumscribed submucosal lesion (Fig. 2a) formed by intersecting fascicles of monotonous spindle cells with eosinophilic cytoplasm and indistinct borders (Fig. 2b).
case_images: IHC analysis of the excised tumor. Lesional cells were strongly positive for the smooth muscle cell marker desmin (a) whereas they were negative for GIST markers CD117 (b), DOG1 (c), and CD34 (d).
case_images: crg-2023-0017-0001-533550_F03.jpg
case_images: PMC10624942_01_crg-2023-0017-0001-533550_F03.jpg
case_images: F3
case_images: Immunohistochemical analysis of the excised tumor revealed the lesional cells were strongly positive for desmin (Fig. 3a) and negative for CD117, DOG1, and CD34 (Fig. 3b-d).