case_images: PMC10666957_01
case_images: Bone marrow cytomorphology of a genetic APL variant with t(11;17)(q23;q21). Visible are promyelocytes with relatively round nuclei and absence of Auer rods.
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case_images: F1
case_images: In contrast to the previous examination, cytomorphology now showed predominantly promyelocytes with relatively round nuclei and absence of Auer rods (shown in Fig. 1).
case_images: Representative karyogram of a genetic APL variant with a t(11;17)(q23;q21).
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case_images: PMC10666957_01_cro-2023-0016-0001-534862_F02.jpg
case_images: F2
case_images: Fig. 2). FISH analysis confirmed the gene fusion of ZBTB16 and RARa in our patient (shown in Fig. 3).
case_images: Metaphase and interphase fluorescence in-situ-hybridization (FISH) using the ZBTB16-RARA Dual Fusion/Translocation FISH Probe (CytoTest, Rockville, USA). Three metaphases were investigated. Left (metaphase): DAPI-stain (blue), the probe on 11q23 (red), the probe on 17q21 (green). Middle (metaphase): inverted DAPI-stain with the normal chromosomes 11 and 17 (blue arrows) and the aberrant derivative chromosomes caused by the t(11;17) (blue arrows). Right (interphase): fusion of ZBTB16 and RARa (yellow). FISH result according to the ISCN2020 nomenclature: ish t(11;17)(q23;q21) (ZBTB16+,RARA+;RARA+,ZBTB16+) nuc ish ZBTB16,RARA)x3)(ZTBT16 con RARAx2).
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case_images: PMC10666957_01_cro-2023-0016-0001-534862_F03.jpg
case_images: F3
case_images: Fig. 2). FISH analysis confirmed the gene fusion of ZBTB16 and RARa in our patient (shown in Fig. 3).