case_images: PMC11827718_01
case_images: Extensively drug-resistant (XDR) E. coli against Ceftazidime/Avibactam/Aztreonam combination regimen in HFS-E. coli. Total bacterial population counts in CFU/mL over time. Data points for XDR E. coli (red) represent the geometric mean +- SD of biological duplicates. Antibiotic infusions were dosed every 8 h (shown in black at the top of the graph). The lower limit of detection (LOD) for quantifying the bacteria was 10 CFU/mL and shown as black dashed line.
case_images: TID-27-e14396-g002.jpg
case_images: PMC11827718_01_TID-27-e14396-g002.jpg
case_images: tid14396-fig-0001
case_images: ATM 120 mug/L. A T 1/2 of 2.48 h was simulated in the HFS-E. coli (Table S2 and Figure S1). Antibiotic powders were dissolved in solvents recommended by the manufacturers (CAZ; Sigma, AVI; MCE, and ATM; TOKU-E).