case_images: PMC8597364_01
case_images: Evolution of leukocytes, neutrophils and CD4 T-lymphocytes. CD4: Cluster of differentiation 4; HLH: Hemophagocytic lymphohistiocytosis
case_images: RJME-62-1-279-fig1.jpg
case_images: PMC8597364_01_RJME-62-1-279-fig1.jpg
case_images: F1
case_images: CD4 T-lymphocytes number and neutrophil count remained low (Figure 1), with G-CSF having a prompt but brief favorable response, continuous administration of at least two doses per week being necessary.
case_images: Bone marrow aspirate showing lymphophagocytosis. May-Grunwald-Giemsa (MGG) staining, x1000
case_images: RJME-62-1-279-fig2.jpg
case_images: PMC8597364_01_RJME-62-1-279-fig2.jpg
case_images: F2
case_images: A bone marrow aspirate revealed granulocytic hypoplasia, pleomorphic lymphoid population, reactive macrophages (irregular nuclear shape, increased in volume, intranuclear vacuoles, eosinophilic cytoplasm), which presented hemophagocytosis and lymphocytosis (Figures 2 and 3) and, in association with fever, bicytopenia (neutrophilia and moderate normochromic normocytic anemia), hypofibrinogenemia and hypertriglyceridemia allowed the diagnosis of HLH secondary to HIV infection.
case_images: Bone marrow aspirate showing hemophagocytosis. MGG staining, x1000
case_images: RJME-62-1-279-fig3.jpg
case_images: PMC8597364_01_RJME-62-1-279-fig3.jpg
case_images: F3
case_images: A bone marrow aspirate revealed granulocytic hypoplasia, pleomorphic lymphoid population, reactive macrophages (irregular nuclear shape, increased in volume, intranuclear vacuoles, eosinophilic cytoplasm), which presented hemophagocytosis and lymphocytosis (Figures 2 and 3) and, in association with fever, bicytopenia (neutrophilia and moderate normochromic normocytic anemia), hypofibrinogenemia and hypertriglyceridemia allowed the diagnosis of HLH secondary to HIV infection.