case_images: PMC4624891_01
case_images: CT scans of the chest and abdomen show large bilateral pleural effusions (a) and severe ascites (b). There is a 4.2 cm mass in the head of the pancreas (c).
case_images: CRIONM2015-789616.001.jpg
case_images: PMC4624891_01_CRIONM2015-789616.001.jpg
case_images: fig1
case_images: CT of the chest revealed bilateral pleural effusions, severe ascites, and an enlarged head of the pancreas (Figure 1).
case_images: Cytologic evaluation of the pleural fluid shows large atypical lymphoid cells (arrows) ((a) H&E, x100) expressing HHV8, CD30, and CD138 ((b), (c), and (d), resp.). The atypical cells show high proliferation index highlighted by Ki-67 immunostain (e) and positive staining for Epstein-Barr Virus (EBV) by in situ hybridization (f).
case_images: CRIONM2015-789616.002.jpg
case_images: PMC4624891_01_CRIONM2015-789616.002.jpg
case_images: fig2
case_images: Further cytologic evaluation of the pleural and ascitic fluid revealed scattered large atypical lymphoid cells expressing HHV-8, CD30, CD79A, MUM-1, CD56, and CD138 (Figure 2).
case_images: The cut surface of liver shows a well-demarcated perivascular infiltration marked by reddish-brown tumorous tissue (arrows) (a). The head of the pancreas shows a reddish-brown infiltrating lesion (arrows) (d). Representative microscopic sections show spindle cells proliferation involving hepatic lobules ((b) H&E, x20) and pancreatic acini ((e) H&E, x10) with positive staining for HHV-8 antibody consistent with Kaposi's sarcoma ((c), (f)).
case_images: CRIONM2015-789616.003.jpg
case_images: PMC4624891_01_CRIONM2015-789616.003.jpg
case_images: fig3
case_images: The liver showed a well-demarcated perivascular infiltration marked by reddish-brown tumorous tissue (Figure 3). The head of the pancreas showed a 4 x 5 cm reddish-brown infiltrating lesion (Figure 3). CD34 and HHV-8 immunostains provided a positive result confirming the diagnosis (Figure 3).
case_images: Kaposi's sarcoma with well-circumscribed areas of raised hemorrhagic mucosa in large intestine ((a), (b)) and stomach ((c), (d)).
case_images: CRIONM2015-789616.004.jpg
case_images: PMC4624891_01_CRIONM2015-789616.004.jpg
case_images: fig4
case_images: The small and large intestine, along with stomach, showed widely separated, well-circumscribed, and circumferential areas of raised hemorrhagic mucosa (Figure 4).