case_images: PMC5394820_01
case_images: Computed tomography showing a primary tumor at the right side of the base of tongue measuring 3 cm x 2 cm x 1 cm
case_images: JPGM-63-50-g001.jpg
case_images: PMC5394820_01_JPGM-63-50-g001.jpg
case_images: F1
case_images: CT scan showed a growth on the right side of the base of tongue measuring 3 cm x 2 cm x 1 cm [Figure 1].
case_images: (a) Photomicrograph showing monomorphic tumor cells arranged in small clusters, nests, and sheets suggestive of neuroendocrine differentiation (H and E, x100), (b) tumor cells are seen invading the fibroconnective stroma (H and E, x200), (c) individual tumors cells are round with scant eosinophilic cytoplasm and round to oval hyperchromatic nucleus (H and E, x400), (d) photomicrograph showing tumor necrosis and crush artifact commonly seen in small cell neuroendocrine carcinoma (H and E, x200)
case_images: JPGM-63-50-g002.jpg
case_images: PMC5394820_01_JPGM-63-50-g002.jpg
case_images: F2
case_images: Abnormal mitotic figures (7-8/10 high power fields), necrosis, and crush artifact were also seen [Figure 2a-d].
case_images: Immunohistochemistry: Tumor cells demonstrating positivity for neuron-specific enolase (a), synaptophysin (b), chromogranin (c), and cytokeratin 7 (d) (immunostain x 200)
case_images: JPGM-63-50-g003.jpg
case_images: PMC5394820_01_JPGM-63-50-g003.jpg
case_images: F3
case_images: On immunohistochemistry, the tumor cells showed positivity for neuron-specific enolase, synaptophysin, chromogranin, pan-cytokeratin (CK), and CK7 [Figure 3a-d].