case_images: PMC6719276_01
case_images: Canine-photographs of progressive plaques over the right (a) and left (b) corneas.
case_images: CRIVEM2019-8516981.001.jpg
case_images: PMC6719276_01_CRIVEM2019-8516981.001.jpg
case_images: fig1
case_images: The right cornea was completely covered (Figure 1(a)) while only 1/3 of the left cornea was effaced (Figure 1(b)).
case_images: (a) Anterior cornea of the right eye (100X, H&E stain): surface epithelium is markedly hyperplastic with expansion of underlying stroma by small caliber vessels and multifocal pyogranulomatous nodules surrounded by infiltrates of lymphocytes and plasma cells. (b) Anterior cornea of the right eye (200X, H&E stain): higher magnification of previously described lesion highlighting pyogranulomatous inflammation.
case_images: CRIVEM2019-8516981.002.jpg
case_images: PMC6719276_01_CRIVEM2019-8516981.002.jpg
case_images: fig2
case_images: Histopathologic evaluation of both eyes revealed markedly expanded corneas due to pronounced hyperplasia of the surface epithelium, along with neovascularization, fibrosis of the stroma, and a marked infiltrate of numerous distinct pyogranulomas surrounded by a diffuse infiltrate of lymphocytes and plasma cells (Figure 2(a)). The pyogranulomas were characterized by a peripheral zone of epithelioid macrophages, fewer lymphocytes and plasma cells, and a central zone of polymorphonuclear cells (Figure 2(b)).