case_images: PMC10778201_01
case_images: Patient (A) ulcerative lesions with massive purulent discharges in perianal area before abrocitinib treatment (Aa); extensive infiltration of lymphocytes and neutrophils and necrotising vasculitis (Ab, x100); significant improvement of skin lesions 1 week after abrocitinib and cyclosporine A treatment (Ac) and 4 weeks after starting abrocitinib treatment (Ad). Patient (B) multiple ulcers and tan necrosis near both ankle joints (Ba, b); cellulose like degeneration of capillary wall, and vascular thrombosis and inflammation (Bc, x100); markedly improvement of skin lesions 1 week (Bd, e) and 6 weeks (Bf, g) after abrocitinib treatment. Patient (C) nodules and abscesses of the axillary (Ca, b); hyperplasia of the hair follicle infundibulum epithelium and infiltration of lymphocyte (Cc, x40); improvement of skin lesions 2 weeks after abrocitinib and doxycycline treatment (Cd, e) and 6 weeks after starting abrocitinib treatment (Cf, g).
case_images: CCID-17-35-g0001.jpg
case_images: PMC10778201_03_CCID-17-35-g0001.jpg
case_images: f0001
case_images: Patient C, a 17-year-old male, was referred with 3-year history of recurrent abscesses with pain in both armpits (Figure 1Ca and Cb). Histopathological examination found hyperplasia of the hair follicle infundibulum epithelium, perifollicular infiltration of lymphocytes in the dermis (Figure 1Cc). The pain and the size of abscesses decreased significantly after two weeks (Figure 1Cd and Ce). Six weeks after starting abrocitinib treatment, the lesions continued to improve, with nearly complete clearance (Figure 1Cf and Cg).
case_images: PMC10778201_02
case_images: Patient (A) ulcerative lesions with massive purulent discharges in perianal area before abrocitinib treatment (Aa); extensive infiltration of lymphocytes and neutrophils and necrotising vasculitis (Ab, x100); significant improvement of skin lesions 1 week after abrocitinib and cyclosporine A treatment (Ac) and 4 weeks after starting abrocitinib treatment (Ad). Patient (B) multiple ulcers and tan necrosis near both ankle joints (Ba, b); cellulose like degeneration of capillary wall, and vascular thrombosis and inflammation (Bc, x100); markedly improvement of skin lesions 1 week (Bd, e) and 6 weeks (Bf, g) after abrocitinib treatment. Patient (C) nodules and abscesses of the axillary (Ca, b); hyperplasia of the hair follicle infundibulum epithelium and infiltration of lymphocyte (Cc, x40); improvement of skin lesions 2 weeks after abrocitinib and doxycycline treatment (Cd, e) and 6 weeks after starting abrocitinib treatment (Cf, g).
case_images: CCID-17-35-g0001.jpg
case_images: PMC10778201_03_CCID-17-35-g0001.jpg
case_images: f0001
case_images: Patient C, a 17-year-old male, was referred with 3-year history of recurrent abscesses with pain in both armpits (Figure 1Ca and Cb). Histopathological examination found hyperplasia of the hair follicle infundibulum epithelium, perifollicular infiltration of lymphocytes in the dermis (Figure 1Cc). The pain and the size of abscesses decreased significantly after two weeks (Figure 1Cd and Ce). Six weeks after starting abrocitinib treatment, the lesions continued to improve, with nearly complete clearance (Figure 1Cf and Cg).
case_images: PMC10778201_03
case_images: Patient (A) ulcerative lesions with massive purulent discharges in perianal area before abrocitinib treatment (Aa); extensive infiltration of lymphocytes and neutrophils and necrotising vasculitis (Ab, x100); significant improvement of skin lesions 1 week after abrocitinib and cyclosporine A treatment (Ac) and 4 weeks after starting abrocitinib treatment (Ad). Patient (B) multiple ulcers and tan necrosis near both ankle joints (Ba, b); cellulose like degeneration of capillary wall, and vascular thrombosis and inflammation (Bc, x100); markedly improvement of skin lesions 1 week (Bd, e) and 6 weeks (Bf, g) after abrocitinib treatment. Patient (C) nodules and abscesses of the axillary (Ca, b); hyperplasia of the hair follicle infundibulum epithelium and infiltration of lymphocyte (Cc, x40); improvement of skin lesions 2 weeks after abrocitinib and doxycycline treatment (Cd, e) and 6 weeks after starting abrocitinib treatment (Cf, g).
case_images: CCID-17-35-g0001.jpg
case_images: PMC10778201_03_CCID-17-35-g0001.jpg
case_images: f0001
case_images: Patient C, a 17-year-old male, was referred with 3-year history of recurrent abscesses with pain in both armpits (Figure 1Ca and Cb). Histopathological examination found hyperplasia of the hair follicle infundibulum epithelium, perifollicular infiltration of lymphocytes in the dermis (Figure 1Cc). The pain and the size of abscesses decreased significantly after two weeks (Figure 1Cd and Ce). Six weeks after starting abrocitinib treatment, the lesions continued to improve, with nearly complete clearance (Figure 1Cf and Cg).