case_images: PMC3109785_01
case_images: Periodic acid Schiff (PAS) stain, 400x magnification, shows an enlarged glomerulus with deposits which are PAS negative and occasional PAS positive hyaline caps. Tubules and interstitium are normal
case_images: IJN-21-52-g001.jpg
case_images: PMC3109785_01_IJN-21-52-g001.jpg
case_images: F0001
case_images: These deposits were negative for periodic acid Schiff (PAS) [Figure 1], silver methanamine [Figure 2], and Congo red stains [Figure 3]. There was associated PAS positive peripheral hyalinosis in some glomeruli [Figure 1].
case_images: Silver stain, 400x view shows deposits are silver negative
case_images: IJN-21-52-g002.jpg
case_images: PMC3109785_01_IJN-21-52-g002.jpg
case_images: F0002
case_images: These deposits were negative for periodic acid Schiff (PAS) [Figure 1], silver methanamine [Figure 2], and Congo red stains [Figure 3].
case_images: Deposits were not congophilic
case_images: IJN-21-52-g003.jpg
case_images: PMC3109785_01_IJN-21-52-g003.jpg
case_images: F0003
case_images: These deposits were negative for periodic acid Schiff (PAS) [Figure 1], silver methanamine [Figure 2], and Congo red stains [Figure 3].
case_images: Immuno-fluorescence stain: the deposits were negative for all IgG, IgM and complements
case_images: IJN-21-52-g004.jpg
case_images: PMC3109785_01_IJN-21-52-g004.jpg
case_images: F0004
case_images: Direct immunofluorescence study showed focal and segmental deposits of C3c corresponding to peripheral hyalinosis [Figure 4].
case_images: Electron microscopic study of renal biopsy specimen fixed using gluteraldehyde, viewed under 40,000x magnification revealed abundant subendothelial deposits of large fibers (97nm in width) with long spacing striations suggestive of collagen fibers; confirming the diagnosis of collagenous glomerulopathy
case_images: IJN-21-52-g005.jpg
case_images: PMC3109785_01_IJN-21-52-g005.jpg
case_images: F0005
case_images: The biopsy cores fixed with gluteraldehyde revealed abundant subendothelial deposits of large fibers (97 nm in width) with long spacing striations (25-30 nm), which were characteristic of collagen fibers [Figure 5].
case_images: PMC3109785_02
case_images: Kidney biopsy slide stained with hemotoxylin-eosin stain and periodic acid Schiff stain (PAS), viewed under 400x magnification shows an enlarged glomerulus with increased mesangial matrix and mesangial interposition with diffuse membrane thickening. Tubules and interstitium are normal
case_images: IJN-21-52-g006.jpg
case_images: PMC3109785_02_IJN-21-52-g006.jpg
case_images: F0006
case_images: Light microscopy and immunoflourescence revealed features suggestive of collagenofibrotic glomerulopathy [Figure 6], and was confirmed by electron microscopy [Figure 7].
case_images: Electron microscopic study of renal biopsy specimen fixed using gluteraldehyde, viewed under 40,000x magnification revealed abundant subendothelial deposits of large fibers (97nm in width) with long spacing striations suggestive of collagen fibers; confirming the diagnosis of collagenous glomerulopathy
case_images: IJN-21-52-g007.jpg
case_images: PMC3109785_02_IJN-21-52-g007.jpg
case_images: F0007
case_images: Light microscopy and immunoflourescence revealed features suggestive of collagenofibrotic glomerulopathy [Figure 6], and was confirmed by electron microscopy [Figure 7].