case_images: PMC10203611_01
case_images: (A, B) Preoperative positive and lateral x-rays of the knee joint. (C, D) Preoperative CT plain scan of the right knee joint. (E) Anteroposition radiographs of the right hip. (F) X-ray of the chest. (G, H) Postoperative right knee joint anteroposterior and lateral x-ray showed good alignment of the broken end and internal fixation in place.
case_images: fendo-14-1164386-g001.jpg
case_images: PMC10203611_03_fendo-14-1164386-g001.jpg
case_images: f1
case_images: After the restoration of the lateral tibia plateau, the allograft bone was filled, and the internal fixation was performed with anatomic bone plates ( Figures 1G, H ).
case_images: PMC10203611_02
case_images: (A, B) Preoperative positive and lateral x-rays of the knee joint. (C, D) Preoperative CT plain scan of the right knee joint. (E) Anteroposition radiographs of the right hip. (F) X-ray of the chest. (G, H) Postoperative right knee joint anteroposterior and lateral x-ray showed good alignment of the broken end and internal fixation in place.
case_images: fendo-14-1164386-g001.jpg
case_images: PMC10203611_03_fendo-14-1164386-g001.jpg
case_images: f1
case_images: After the restoration of the lateral tibia plateau, the allograft bone was filled, and the internal fixation was performed with anatomic bone plates ( Figures 1G, H ).
case_images: PMC10203611_03
case_images: (A, B) Preoperative positive and lateral x-rays of the knee joint. (C, D) Preoperative CT plain scan of the right knee joint. (E) Anteroposition radiographs of the right hip. (F) X-ray of the chest. (G, H) Postoperative right knee joint anteroposterior and lateral x-ray showed good alignment of the broken end and internal fixation in place.
case_images: fendo-14-1164386-g001.jpg
case_images: PMC10203611_03_fendo-14-1164386-g001.jpg
case_images: f1
case_images: After the restoration of the lateral tibia plateau, the allograft bone was filled, and the internal fixation was performed with anatomic bone plates ( Figures 1G, H ).
case_images: (A) Volcanic map of differential genes between patients and normal people. (B, C) Upregulated genes and downregulated genes were analyzed by GO enrichment between patients and normal controls. (D) The KEGG pathway between patients and normal controls. (E) T1 = patient, control = normal control, quantitative analysis of transcripts, (F) Protein-protein interaction network.
case_images: fendo-14-1164386-g002.jpg
case_images: PMC10203611_03_fendo-14-1164386-g002.jpg
case_images: f2
case_images: The results of whole blood transcriptome sequencing showed that there were 513 DEGs between the OI patient and the normal control ( Figure 2A ). In addition, the GO enrichment results of 30 downregulated genes showed that natural killer cell-mediated immunity was mainly enriched in BP, MHC protein complexes in CC, and antigen-binding in MF ( Figures 2B, C ). In this study, the results of KEGG signaling pathways were mainly enriched in ECM-receptor interaction ( Figure 2D ). However, the expression of COL1A1 in the normal control was upregulated, with fourfold expression (p-value 0.26 > 0.05) ( Figure 2E ). Cytoscape software (v 3.9.1) for visualization. Cytohub plug-in was used to analyze the ECM-receptor interaction-related genes, including ITGA2B, LAMC1, LAMB2, COL6A2, ITGB3, THBS1, ITGB5, GP9, and ITGA1 ( Figure 2F ).