case_images: PMC10653706_01
case_images: CT scan of the abdomen showing right hepatic mass involving the large portion of the gallbladder (white arrows) in our patient with large cell neuroendocrine carcinoma of the gallbladder. CT, computed tomography.
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case_images: F2
case_images: Computed tomography of the abdomen demonstrated an ill-defined 7.2 x 4.9 cm hypodense lesion in the GB fossa with extension into the hepatic parenchyma (Fig. 2).
case_images: Right lobe of liver/gallbladder mass core biopsy showing poorly differentiated carcinoma consistent with large cell neuroendocrine carcinoma. Foci of individual cell necrosis and mitosis present (H&E, x400. Inset x40).
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case_images: F3
case_images: Histopathology of the biopsy revealed a large cell NET (Fig. 3).
case_images: Immunoprofile positive for CD56, chromogranin, and synaptophysin. Ki-67 shows 70% nuclear staining. These findings are consistent with large cell neuroendocrine carcinoma. Positive CK 20 and CDX2 favor a gastrointestinal tract primary.
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case_images: F4
case_images: Immunohistochemical analysis showed tumor cells were positive for CD56, synaptophysin, chromogranin, CK 20, and Ki67 and negative for TTF1 and CK7 favoring the GI origin of NEC (Fig. 4).
case_images: PET scan images showing, FDG avid liver mass contiguous with gallbladder with extensive retroperitoneal, portacaval, and left supraclavicular lymphadenopathy in our patient with known diagnoses of the large cell neuroendocrine carcinoma of the gallbladder. FDG, fluorodeoxyglucose.
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case_images: PMC10653706_01_crg-2023-0017-0001-534520_F05.jpg
case_images: F5
case_images: PET scan showed extensive involvement in liver and peritoneum (Fig. 5).