case_images: PMC11269156_01
case_images: Pathology and immunohistochemistry of a left inguinal lymph node biopsy (A) HE 40x:the tumors appear to be arranged in sheets or nests; (B) HE 400x:The cytoplasm of tumor cells is sparse, the cell boundary is unclear. The round or oval nuclei and nuclear hyperchromatism and fission can be seen. immunohistochemical staining: (C) Vimentin: Diffuse cytoplasmic positive of tumor cells (HE 400x.); (D) INI-1: Nucleus positive (HE 400x.); (E) Ki67: It shows high proliferation of the tumor (400x.). HE, Hematoxylin-eosin stain.
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case_images: f1
case_images: Thyroid transcription factor 1(TTF-1) (-), Cluster of Differentiation 99(CD99) (-), Friend leukemia integration 1(Fli-1) (-), Cluster of Differentiation 30(CD30) (-), Integrase interactor 1(INI-1) (+), and Ki67 antigen (Ki67) (90%+) ( Figure 1 ). The Epstein-Barr virus-encoded small RNA (EBER) in-situ hybridization result was negative. NGS of RNAseq fusion genes, including BCOR and CIC fusion gene, were negative ( Figure 1 ).
case_images: 2020-7-10 CT scan: the metastatic tumor in the right lower lobe of the lung and the long diameter was 0.69 cm [red arrow, (A)]. Mediastinal lymph nodes were not significantly enlarged (B). Left acetabular metastases [red arrow, (C)]. Abdominal and abdominal lymph nodes were not significantly enlarged (D) No enlarged lymph nodes were found in the right hilum and the retroperitoneal area. The left pelvic lymph nodes were found and the short diameter was 4.05cm [red arrow, (E)].
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case_images: f2
case_images: As of April 2023, the patient had a progression-free survival time of 26 months based on the last examination ( Figures 2 - 11 ).
case_images: 2020-9-16 CT scan: The original metastatic tumor in the right lower lobe of the lung disappeared (A); no enlarged lymph nodes were found in the right hilum (B). Left acetabular metastases [red arrow, (C)]. The short diameter of retroperitoneal lymph nodes was 0.91 cm which was a non-confirmed metastases [red arrow, (D)], and the short diameter of left pelvic lymph nodes was 2.98 cm [red arrow, (E)]. The efficacy was SD. SD, stable disease.
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case_images: f3
case_images: As of April 2023, the patient had a progression-free survival time of 26 months based on the last examination ( Figures 2 - 11 ).
case_images: 2020-11-3 CT scan: The original right lower lobe of the lung metastatic tumor disappeared (A); short diameter of new right hilar lymph node was 0.83 cm [red arrow, (B)]; Left acetabular metastases (red arrow, (C)). The short diameter of retroperitoneal lymph nodes was 1.01 cm which was bigger than before [red arrow, (D)], and the short diameter of left pelvic lymph nodes was 2.76 cm [red arrow, (E)]. The efficacy was PD. PD, progressive disease.
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case_images: f4
case_images: As of April 2023, the patient had a progression-free survival time of 26 months based on the last examination ( Figures 2 - 11 ).
case_images: 2020-12-22 CT scan: The right lower lobe of the lung metastatic tumor reappeared [red arrow, (A)] and the long diameter was 0.91 cm short diameter of right hilar lymph node was 1.66 cm [red arrow, (B)]; Left acetabular metastases [red arrow, (C)]. the short diameter of retroperitoneal lymph nodes was 1.66 cm, and the short diameter of left pelvic lymph nodes was 3.45 cm [red arrow, (D, E)]. The efficacy was PD. PD, progressive disease.
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case_images: f5
case_images: As of April 2023, the patient had a progression-free survival time of 26 months based on the last examination ( Figures 2 - 11 ).
case_images: 2021-2-3 CT scan: The right lower lung metastatic tumor was 1.28 cm [red arrow, (A)]; short diameter of right hilar lymph node 2.15 cm [red arrow, (B)]. Left acetabular metastases [red arrow, (C)]. The number of retroperitoneal lymph nodes increased and the short diameter was 1.61 cm [red arrow, (D)], and the left pelvic lymph nodes were 4.02 cm [red arrow, (E)]. The efficacy was PD. PD, progressive disease.
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case_images: PMC11269156_01_fonc-14-1416241-g006.jpg
case_images: f6
case_images: As of April 2023, the patient had a progression-free survival time of 26 months based on the last examination ( Figures 2 - 11 ).
case_images: 2021-3-9 CT scan: The number of lung metastases increased, and the length of the metastatic tumor in the right lower lobe of lung was 1.62 cm [red arrow, (A)], which was enlarged; short diameter of right hilar lymph node was 2.10 cm [red arrow, (B)]; Left acetabular metastases (C). the short diameter of retroperitoneal lymph nodes was 2.00 cm, and the short diameter of left pelvic lymph nodes was 4.14 cm [red arrow, (D, E)]. The efficacy was unconfirmed progressive disease (iUPD) according irRECIST. irRECIST, immune-related response evaluation criteria in solid tumors.
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case_images: As of April 2023, the patient had a progression-free survival time of 26 months based on the last examination ( Figures 2 - 11 ).
case_images: 2021-8-24: Length of metastatic tumor in lower right lung 1.59 cm [red arrow, (A)]; short diameter of right hilar lymph node 1.53 cm [red arrow, (B)]; the short diameter of retroperitoneal lymph nodes was 1.61 cm, and the short diameter of left pelvic lymph nodes was 3.11 cm [red arrow, (C, D)]. The acetabulum was not scanned. The efficacy was SD. SD, stable disease.
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case_images: f8
case_images: As of April 2023, the patient had a progression-free survival time of 26 months based on the last examination ( Figures 2 - 11 ).
case_images: 2021-12-15: Length of metastatic tumor in lower lobe of lung was 1.13 cm [red arrow, (A)]; short diameter of right hilar lymph node 1.26 cm [red arrow, (B)]; the short diameter of retroperitoneal lymph nodes was 1.56 cm [red arrow, (C)], and the pelvic cavity was not scanned. The efficacy was PR. PR, partial response.
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case_images: f9
case_images: As of April 2023, the patient had a progression-free survival time of 26 months based on the last examination ( Figures 2 - 11 ).
case_images: 2023-4-13: The original right lower lobe of lung metastatic tumor disappeared (A); The original right hilar enlargement lymph node disappeared (B); Left acetabular metastases [red arrow, (C)]. The short diameter of retroperitoneal lymph nodes was 0.89cm [red arrow, (D)], and the short diameter of left pelvic lymph nodes was 2.13cm [red arrow, (E)].The efficacy was PR. PR, Partial response; SD, Stable disease; PD, Progressive disease; irRECIST, immune-related response evaluation criteria in solid tumors.
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case_images: f10
case_images: As of April 2023, the patient had a progression-free survival time of 26 months based on the last examination ( Figures 2 - 11 ).
case_images: A timeline with relevant data from the episode of care.
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case_images: f11
case_images: As of April 2023, the patient had a progression-free survival time of 26 months based on the last examination ( Figures 2 - 11 ).