case_images: PMC11390195_01
case_images: Lymphoproliferative disorders in patient 1. (a) Pathology of the mass shows medium-to-large lymphoid cells with pale cytoplasm and polymorphic nuclei (H&E stain x200). (b) Immunohistochemical staining shows that the lymphoid cells are positive for CD20. (c) Lymphoid cells are positive for EBV-encoded small RNA in in situ hybridization. H&E: hematoxylin and eosin; EBV: Epstein-Barr virus.
case_images: CRIRH2023-5780733.001.jpg
case_images: PMC11390195_01_CRIRH2023-5780733.001.jpg
case_images: fig1
case_images: Biopsy of the mass showed medium-to-large lymphoid cells with pale cytoplasm and polymorphic nuclei (Figure 1(a)). Immunohistochemical staining showed that lymphoid cells were positive for CD20 and EBV-encoded small RNA was positive in in situ hybridization (Figures 1(b) and 1(c)).
case_images: PMC11390195_02
case_images: Lymphoproliferative disorders in patient 2. (a) Laryngoscopy shows a mass in the midpharynx. (b) Gadolinium-enhanced magnetic resonance imaging shows a mass (47 x 37 x 52 mm) in the midpharynx. (c) Histopathology of the mass shows an accumulation of atypical lymphoid cells (H&E stain x200). A diagnosis of DLBCL is made. H&E: hematoxylin and eosin; DLBCL: diffuse large B-cell lymphoma.
case_images: CRIRH2023-5780733.002.jpg
case_images: PMC11390195_02_CRIRH2023-5780733.002.jpg
case_images: fig2
case_images: Laryngoscopy (Figure 2(a)) and gadolinium-enhanced magnetic resonance imaging revealed a mass (47 x 37 x 52 mm) in the midpharynx (Figure 2(b)). A biopsy of the mass was performed and the histopathology showed an accumulation of atypical lymphoid cells that were positive for CD20, CD79a, and Bcl-6, whereas negative for CD3 and CD30 (Figure 2(c)).