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case_images: Patient's skin condition.
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case_images: Five months later, the patient was admitted to the hospital presenting with a recurrence of eczema, facial swelling, widespread dark patches on the body, and a generalized rash with erosion and crusts on the extremities (Figure 1).
case_images: Colonoscopy administration. Bacterial fluid injection tube (A) and its positioning imaging (B).
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case_images: The bacterial solution was injected via colonic catheterization, using an injection tube to administer 50 mL of the solution into the terminal ileum and ileocecum once daily for three consecutive days (Figure 2).
case_images: Patient's skin condition after the second FMT (A); after the third FMT (B).
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case_images: After the second day of FMT treatment, supplemented with probiotics, prebiotics, and other medications, the patient experienced a notable reduction in frontal and facial erythema, as well as alleviation of pimples and scales on the limbs (Figure 3A). The patient also reported a significant relief in itchiness throughout their body (Figure 3B).
case_images: Shannon index (A); relative species abundance at phylum level (B) and genus level (C).
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case_images: After FMT, the Shannon index, which represents the alpha diversity of the sample, increased in the gut microbiota, indicating an increase in microbial diversity within the gut (Figure 4A). At the phylum level, the gut microbiota of patients was dominated by Firmicutes before FMT, while after FMT, there was a significant decrease in Firmicutes and a notable increase in Bacteroidota and Verrucomicrobiota (Figure 4B). A significant change in the microbiota was observed at the genus level after FMT (Figure 4C).