case_images: PMC3914224_01
case_images: Renal graft biopsies. In case 1, histological findings were irrelevant; no viral inclusions were identified by light microscopy (H&E (a) and (b)) or immunohistochemistry. Renal biopsy of case 2 demonstrated focal interstitial necrotizing granulomata with neutrophils, plasma cells, and lymphocytes ((c) H&E and (d) PAS stain); note that the glomeruli are not affected. Control graft biopsy only demonstrated minimal interstitial fibrosis ((e) PAS stain and (f) Masson trichromic stain).
case_images: CRIM.NEPHROLOGY2013-195753.001.jpg
case_images: PMC3914224_02_CRIM.NEPHROLOGY2013-195753.001.jpg
case_images: fig1
case_images: A graft biopsy was also performed revealing histopathological findings consistent with adenovirus nephritis (Figures 1(c) and 1(d)). PCR for adenovirus were negative on two subsequent determinations (Figure 3). Posterior SCr determination decreased to 1.4 mg/dL, and a control graft biopsy performed 2 months after discharge showed less than 5% of interstitial fibrosis, without inflammatory infiltrate or other acute change (Figures 1(e) and 1(f)).
case_images: Case 1: correlation of SCr, leukocytes, and treatment administration.
case_images: CRIM.NEPHROLOGY2013-195753.002.jpg
case_images: PMC3914224_01_CRIM.NEPHROLOGY2013-195753.002.jpg
case_images: fig2
case_images: B19 antigenemia has remained negative. Blood and urine real-time PCR for adenovirus has remained negative in 3 serial subsequent determinations (Figure 2).
case_images: PMC3914224_02
case_images: Renal graft biopsies. In case 1, histological findings were irrelevant; no viral inclusions were identified by light microscopy (H&E (a) and (b)) or immunohistochemistry. Renal biopsy of case 2 demonstrated focal interstitial necrotizing granulomata with neutrophils, plasma cells, and lymphocytes ((c) H&E and (d) PAS stain); note that the glomeruli are not affected. Control graft biopsy only demonstrated minimal interstitial fibrosis ((e) PAS stain and (f) Masson trichromic stain).
case_images: CRIM.NEPHROLOGY2013-195753.001.jpg
case_images: PMC3914224_02_CRIM.NEPHROLOGY2013-195753.001.jpg
case_images: fig1
case_images: A graft biopsy was also performed revealing histopathological findings consistent with adenovirus nephritis (Figures 1(c) and 1(d)). PCR for adenovirus were negative on two subsequent determinations (Figure 3). Posterior SCr determination decreased to 1.4 mg/dL, and a control graft biopsy performed 2 months after discharge showed less than 5% of interstitial fibrosis, without inflammatory infiltrate or other acute change (Figures 1(e) and 1(f)).
case_images: Case 2: correlation of SCr, leukocytes, and treatment administration.
case_images: CRIM.NEPHROLOGY2013-195753.003.jpg
case_images: PMC3914224_02_CRIM.NEPHROLOGY2013-195753.003.jpg
case_images: fig3
case_images: PCR for adenovirus were negative on two subsequent determinations (Figure 3). Posterior SCr determination decreased to 1.4 mg/dL, and a control graft biopsy performed 2 months after discharge showed less than 5% of interstitial fibrosis, without inflammatory infiltrate or other acute change (Figures 1(e) and 1(f)).