case_images: PMC6066556_01
case_images: (200X magnification). (A) HER-2 immunostain showing overexpression of HER-2 with intense circumferential staining of the tumor cells. (B) Hematoxylin and Eosin stained section showing malignant glands infiltrating adipose tissue.
case_images: fonc-08-00274-g0001.jpg
case_images: PMC6066556_01_fonc-08-00274-g0001.jpg
case_images: F1
case_images: However, there was perineural invasion as well as involvement of the SCM (Figure 1). HER-2 staining was performed on the previous surgical specimen and showed overexpression of HER-2 (Figure 1).
case_images: (A) Transverse abdominal PET scan before systemic therapy with TDM1, showing FDG avid liver lesion. (B) Transverse abdominal PET scan after treatment, showing disappearance of FDG avid liver lesion.
case_images: fonc-08-00274-g0002.jpg
case_images: PMC6066556_01_fonc-08-00274-g0002.jpg
case_images: F2
case_images: Follow up PET scan four months later, showed resolution of the liver metastatic lesion (Figure 2).
case_images: (A) Coronal Brain MRI, T1 with contrast showing a hyperintense lesion in the left cerebellar lobe before systemic therapy with TDM1. (B) Coronal Brain MRI, T1 with contrast showing decrease in the size of the lesion after treatment.
case_images: fonc-08-00274-g0003.jpg
case_images: PMC6066556_01_fonc-08-00274-g0003.jpg
case_images: F3
case_images: MRI brain revealed a significant decrease in the number and size of the metastatic enhancing brain lesions, in keeping with a good response to treatment (Figure 3).