case_images: PMC10837006_01
case_images: Abdominal and pelvic CT revealing significant hepatosplenomegaly and multiple hypoenhancing nodules scattered throughout the spleen.
case_images: cureus-0016-00000051604-i01.jpg
case_images: PMC10837006_01_cureus-0016-00000051604-i01.jpg
case_images: FIG1
case_images: Subsequent abdominal/pelvic CT and MRI confirmed these findings, with the liver measuring 22 cm in the midclavicular line and the spleen 28.4 cm along the bipolar axis, excluding signs of splenic vein thrombosis (Figure 1).
case_images: Bone marrow biopsy revealing diffuse infiltration by Gaucher cells (some of them delimited by circles).
case_images: cureus-0016-00000051604-i02.jpg
case_images: PMC10837006_01_cureus-0016-00000051604-i02.jpg
case_images: FIG2
case_images: The bone marrow aspirate showed no signs of hematological disease, but the biopsy indicated morphological and immunohistochemical characteristics suggestive of GD Type 1 (Figures 2-4).
case_images: Bone marrow histology showing macrophages laden with glucocerebroside (Gaucher cell, arrow). Periodic acid-Schiff (PAS) and periodic acid-Schiff-diastase (PASD) staining are positive in Gaucher cells (diastase resistant), which is translated by strongly positive granular or fibrillar material in the cytoplasm, with the characteristic 'wrinkled tissue paper' appearance.
case_images: cureus-0016-00000051604-i03.jpg
case_images: PMC10837006_01_cureus-0016-00000051604-i03.jpg
case_images: FIG3
case_images: The bone marrow aspirate showed no signs of hematological disease, but the biopsy indicated morphological and immunohistochemical characteristics suggestive of GD Type 1 (Figures 2-4).
case_images: Immunohistochemical stain for CD68 helped identify isolated Gaucher's cells, which are hystiocytic in nature.
case_images: cureus-0016-00000051604-i04.jpg
case_images: PMC10837006_01_cureus-0016-00000051604-i04.jpg
case_images: FIG4
case_images: The bone marrow aspirate showed no signs of hematological disease, but the biopsy indicated morphological and immunohistochemical characteristics suggestive of GD Type 1 (Figures 2-4).