case_images: PMC4630381_01
case_images: (a) Bone marrow biopsy: hypocellular bone marrow, enlarged and thickened bone trabeculae with encroachment on marrow spaces, and a mosaic pattern with cartilaginous islands (HE x100) and (b) TRAP staining of bone biopsy specimens: increased number of osteoclasts (DAB x200).
case_images: CRIPA2015-786836.001.jpg
case_images: PMC4630381_01_CRIPA2015-786836.001.jpg
case_images: fig1
case_images: Histological examination of bone marrow biopsy specimens revealed hypocellularity, enlarged and thickened bone trabeculae with encroachment on marrow spaces, and a mosaic pattern with cartilaginous islands (Figure 1(a)). CD68 and tartrate-resistant acid phosphatase staining confirmed the presence of increased number of osteoclasts in the peritrabecular region (Figure 1(b)).
case_images: The frontal radiogram of the calvaria: increased periorbital bone density and the typical "space alien" face.
case_images: CRIPA2015-786836.002.jpg
case_images: PMC4630381_01_CRIPA2015-786836.002.jpg
case_images: fig2
case_images: Frontal radiograms revealed enlargement of the calvaria, upward slanting of the greater sphenoid alae, increased periorbital bone density, and typical "space alien" face (Figure 2).