case_images: PMC10625905_01
case_images: Ultrasonographic view of the stomach, showing mucosal thickening and anechoic cysts in the gastric wall.
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case_images: fig1
case_images: The gastric wall layers were not distinguishable, and the gastric mucosa appeared hyperechoic with no evidence of lymphadenopathy (Figure 1).
case_images: Endoscopic views of the stomach, showing hypertrophied gastric folds (A) and a polypoid lesion (B) affecting the gastric body.
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case_images: PMC10625905_01_fvets-10-1287335-g002.jpg
case_images: fig2
case_images: Gastroscopy was performed to further investigate the abnormal findings detected on abdominal ultrasonography; this confirmed the presence of marked hypertrophy of the gastric folds and polypoid lesions (Figure 2).
case_images: Histopathology of a punch biopsy of the thickened gastric mucosa. (A) Note the marked thickening of the mucosa due to the marked hyperplastic parietal cells, without foveolar hyperplasia, with occasional cystic dilatation of the glands (asterisk). Scale bar, 200 mum. (B) Diffuse parietal cell hyperplasia (open arrows) with reduced numbers of chief cells (arrows) is observed. Mild-to-moderate multifocal lymphoplasmacytic infiltration in the lamina propria (arrowheads) and gastric gland with cystic dilatation (*) are also noted. Scale bar, 50 mum. (C) The stroma contains multifocal lymphoplasmacytic infiltrates (arrows) with occasional eosinophils (arrowheads) in the lamina propria. Scale bar, 50 mum. (D) Hyperplastic parietal cells were pleomorphic and vacuolated in the cytoplasm. Hematoxylin and eosin staining, Scale bar, 20 mum.
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case_images: fig3
case_images: Biopsies of the polypoid lesions were obtained during endoscopy; histological examination revealed diffuse and marked parietal cell hyperplasia without foveolar hyperplasia, and occasional cystic dilatation of the gastric glands (Figure 3A). Prominent parietal cell hyperplasia with a decreased number of chief cells were observed (Figure 3B). The stroma contained multifocal inflammatory infiltrates including lymphocytes, plasma cells, and occasional eosinophils in the lamina propria (Figure 3C). Most of the hyperplastic parietal cells were pleomorphic with vacuolated cytoplasm (Figure 3D).
case_images: Ultrasonographic findings of the stomach, showing improvement and resolution of the gastric mucosal abnormalities 2 (A) and 48 months (B) after the discontinuation of omeprazole administration, respectively.
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case_images: fig4
case_images: Two months after the discontinuation, vomiting had ceased and the dog showed improvement in the thickening of the gastric wall and folds, although this had not completely normalized (Figure 4A). At this time, the ultrasonographic findings of the stomach were not significant (Figure 4B), and the serum gastrin concentration was within RI (21.3 ng/L; RI = 10-40 ng/L).