case_images: PMC10561239_01
case_images: Schematic diagram photography of cutaneous lesion improvement. Generalized truncal alopecia and scale with hyperpigmentation were presented before the treatment (A). No significant improvement was observed 2 weeks after the management of superficial pyoderma and Malassezia dermatitis (B). Mild improvement of papule and scale was identified 1 month after hyperadrenocorticism management (C). Generalized skin lesions, including alopecia, were improved after additional hypothyroidism management at 1 month (D), 3 months (E), and 5 months (F).
case_images: fvets-10-1257624-g001.jpg
case_images: PMC10561239_01_fvets-10-1257624-g001.jpg
case_images: fig1
case_images: Physical examination revealed bilateral symmetric truncal alopecia with hyperpigmentation in the dorsum, abdomen, axilla, and inguinal region (Figure 1A). To treat infectious dermatitis, amoxicillin/clavulanic acid (25 mg/kg PO q12h), itraconazole (5 mg/kg PO q24h), and benzoyl peroxide shampoo were prescribed for 2 weeks; however, no significant improvement was observed (Figure 1B). Some responses, such as improvement of papule and scale, were identified after the control of hyperadrenocorticism and infectious dermatitis (Figure 1C), whereas generalized alopecia was improved after levothyroxine administration (Figures 1D-F). After 6 months of levothyroxine administration (7 months of hyperadrenocorticism management), increased total T4 (2.80 ug/dL) and free T4 (5.78 ng/dL) were identified with a general improvement in body condition (Figure 1F), whereas serum TSH was still undetectable.
case_images: 7 T MRI and FDG-PET characteristics of a canine pituitary region. Pre- and post-contrast T1 images in transverse (A,B) and sagittal plane (C,D). Neurohypophysis is presented as a hyperintense signal in the center of the pituitary gland (arrows). The adenohypophysis is surrounding neurohypophysis with an isointense signal in T1 image and is enhanced after gadolinium injection. FDG-PET images in transverse and sagittal planes (E,G). Fusion of T1 MRI and FDG-PET images in transverse and sagittal planes (F,H). On PET images, reddish to yellowish color represents high FDG uptake and bluish to greenish color represents low FDG uptake. The pituitary gland showed lower glucose metabolism than cerebral cortex and white matter. MRI, magnetic resonance imaging; FDG-PET, fluorodeoxyglucose-positron emission tomography.
case_images: fvets-10-1257624-g002.jpg
case_images: PMC10561239_01_fvets-10-1257624-g002.jpg
case_images: fig2
case_images: Immediately after the FDG-PET scan, pre- and post-contrast T1- weighted images of the brain were obtained using a 7 T-MRI scanner (Magnetom 7 T; Siemens, Berlin, Germany; Figures 2A-D). The size of the pituitary gland was measured (height, 3.7 mm, RI: 3.0-7.5 mm; width, 4.8 mm, RI: 4.0-9.0 mm) on the transverse post-contrast T1 weighted image and the pituitary height/brain area (P/B) ratio was 0.2 (RI, <=0.31). The standardized uptake value of the pituitary gland (mean, 0.32; max, 0.47) was lower than those of the gray matter (mean, 0.96; max, 1.02) and caudal colliculus (mean, 1.69; max, 2.44; Figures 2E-H).