case_images: PMC10481821_01
case_images: A 58-year-old male with a painless palpable mass in the left lateral breast, subsequently diagnosed with mammary RosaiDorfman disease. (a) The mammogram of the left breast in a CC view shows an ill-defined isodense region with anterior spiculations in the outer quadrant of the deep breast tissue, corresponding to the area of palpable concern, suggesting a possible tumor or malignancy. (b) The mammogram of the left breast in an XCCL view shows an ill-defined isodense region with anterior spiculations in the lower quadrant of the deep breast tissue, corresponding to the area of palpable concern, suggesting a possible tumor or malignancy.
case_images: JCIS-13-24-g001.jpg
case_images: PMC10481821_01_JCIS-13-24-g001.jpg
case_images: F1
case_images: The mammogram of the right breast was negative, while that of the left breast demonstrated predominantly fatty replaced breast tissue with an ill-defined oval region of increased density in the lower outer quadrant, deep within the breast tissue, corresponding to the area of palpable concern [Figure 1].
case_images: A 58-year-old male with a painless palpable mass in the left lateral breast, subsequently diagnosed with mammary RosaiDorfman disease. (a) The ultrasound without Doppler of the lower outer quadrant of the left breast reveals an irregular micro-lobulated hypoechoic mass measuring 3.4 x 1.8 x 3.3 cm, located at the 4:00 position and approximately 6 cm from the nipple. (b) The ultrasound with Doppler of the lower outer quadrant of the left breast shows mild internal and peripheral vascularity associated with an irregular microlobulated hypoechoic mass, suggesting a possible malignancy or tumor.
case_images: JCIS-13-24-g002.jpg
case_images: PMC10481821_01_JCIS-13-24-g002.jpg
case_images: F2
case_images: To selectively evaluate the area of mammographic concern in the left breast, an ultrasound with Doppler was performed which revealed an irregular micro-lobulated hypoechoic mass with mild internal and peripheral vascularity, measuring 3.4 x 1.8 x 3.3 cm [Figure 2].
case_images: A 58-year-old male with a painless palpable mass in the left lateral breast, subsequently diagnosed with mammary RosaiDorfman disease. The H&E stain (x20) demonstrates a fibrotic lesion characterized by haphazardly arranged bundles of collagen, some bland spindle cell proliferation, mixed inflammatory infiltrates including abundant plasma cells, and pale-stained histiocytes.
case_images: JCIS-13-24-g003.jpg
case_images: PMC10481821_01_JCIS-13-24-g003.jpg
case_images: F3
case_images: Histopathological analysis of the biopsy revealed a haphazardly arranged fibrotic lesion with proliferating bland spindle cells, abundant plasma cells, and pale histiocytes [Figure 3].
case_images: A 58-year-old male with a painless palpable mass in the left lateral breast, subsequently diagnosed with mammary RosaiDorfman disease (RDD). The S100 stain (x40) highlights the presence of S100-positive pale histiocytes with intracytoplasmic lymphocytes, also known as emperipolesis (arrows), a hallmark feature of RDD.
case_images: JCIS-13-24-g004.jpg
case_images: PMC10481821_01_JCIS-13-24-g004.jpg
case_images: F4
case_images: The pale histiocytes were positive for S-100 immunostaining, with the presence of intracytoplasmic lymphocytes, also known as emperipolesis, on close investigation [Figure 4], which was characteristic of RDD.