case_images: PMC5729639_01
case_images: Timeline of serum creatinine results and treatments for subject A.. HUS = hemolytic uremic syndrome, FFP = fresh frozen plasma.
case_images: jkms-33-e4-g001.jpg
case_images: PMC5729639_01_jkms-33-e4-g001.jpg
case_images: F1
case_images: Two years after the KT, her graft function started to deteriorate gradually (Fig. 1).
case_images: Localization of the mutations in 4 patients. Subject A has a mutation of c.3644G>A, subject B has a mutation of c.3593A>T. Subject C has 2 mutations of c.3231T>G and c.3415C>T from both parents and subject D has a mutation of c.3572C>T.
case_images: jkms-33-e4-g002.jpg
case_images: PMC5729639_05_jkms-33-e4-g002.jpg
case_images: F2
case_images: At the age of 4 years, genetic analysis found a heterozygous mutation (c.3572C>T [p.Ser119Leu]) in CFH (Fig. 2), which was inherited from his asymptomatic mother.
case_images: PMC5729639_02
case_images: PMC5729639_03
case_images: Localization of the mutations in 4 patients. Subject A has a mutation of c.3644G>A, subject B has a mutation of c.3593A>T. Subject C has 2 mutations of c.3231T>G and c.3415C>T from both parents and subject D has a mutation of c.3572C>T.
case_images: jkms-33-e4-g002.jpg
case_images: PMC5729639_05_jkms-33-e4-g002.jpg
case_images: F2
case_images: At the age of 4 years, genetic analysis found a heterozygous mutation (c.3572C>T [p.Ser119Leu]) in CFH (Fig. 2), which was inherited from his asymptomatic mother.
case_images: Timeline of serum creatinine results and treatments for subject B.. HUS = hemolytic uremic syndrome, FFP = fresh frozen plasma.
case_images: jkms-33-e4-g003.jpg
case_images: PMC5729639_03_jkms-33-e4-g003.jpg
case_images: F3
case_images: Soon after the KT, she experienced several recurrences of aHUS coinciding with infections, such as Pneumocystis pneumonia and chickenpox (Fig. 3).
case_images: PMC5729639_04
case_images: Analysis of CFH binding by western blotting in subject C. The control sample is from a normal person. Lanes 1, 2, and 3 are the patient's results: lane 1 is before the LT, lane 2 is 2 weeks after the LT, and lane 3 is 25 days after the LT. The plasma CFH levels in the patient increased to within the normal range after the LT.. CFH = complement factor H, LT = liver transplantation.
case_images: jkms-33-e4-g004.jpg
case_images: PMC5729639_04_jkms-33-e4-g004.jpg
case_images: F4
case_images: The patient's serum CFH expression detected by western blotting was relatively low compared to that in a normal control (Fig. 4). After the LT, her plasma complement and CFH levels normalized for the first time in her life (Fig. 4).
case_images: Timeline of serum creatinine results and treatments. (A) Subject C. (B) Subject D.. HUS = hemolytic uremic syndrome, FFP = fresh frozen plasma.
case_images: jkms-33-e4-g005.jpg
case_images: PMC5729639_05_jkms-33-e4-g005.jpg
case_images: F5
case_images: After the operations, he has been free from aHUS for 14 months (Fig. 5B).
case_images: PMC5729639_05
case_images: Localization of the mutations in 4 patients. Subject A has a mutation of c.3644G>A, subject B has a mutation of c.3593A>T. Subject C has 2 mutations of c.3231T>G and c.3415C>T from both parents and subject D has a mutation of c.3572C>T.
case_images: jkms-33-e4-g002.jpg
case_images: PMC5729639_05_jkms-33-e4-g002.jpg
case_images: F2
case_images: At the age of 4 years, genetic analysis found a heterozygous mutation (c.3572C>T [p.Ser119Leu]) in CFH (Fig. 2), which was inherited from his asymptomatic mother.
case_images: Timeline of serum creatinine results and treatments. (A) Subject C. (B) Subject D.. HUS = hemolytic uremic syndrome, FFP = fresh frozen plasma.
case_images: jkms-33-e4-g005.jpg
case_images: PMC5729639_05_jkms-33-e4-g005.jpg
case_images: F5
case_images: After the operations, he has been free from aHUS for 14 months (Fig. 5B).