case_images: PMC11240285_01
case_images: Brain MR and 18F-FDG PET-CT imaging in a patient with anti-DPPX encephalitis. (A, C) Mild atrophy of the hippocampus and temporal lobe in T2-flair imaging. (B1, B2) Normal metabolism in both hippocampus in PET-CT. (D1, D2) Hypometabolism in the bilateral frontal lobes, parietal lobes, and temporal lobes, especially the left side.
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case_images: A third MRI and enhanced scans of the brain revealed non-specific changes with atrophy ( Figure 1 ), while the spinal cord MRI was unremarkable.
case_images: Immunofluorescence in serum and CSF in patients with anti-DPPX encephalitis assessed by cell-based assay (CBA). Positive reaction with transfected HEK 293 cells expressing DPPX after incubation with the patient's serum (A) (titer: 1:1,000) and with CSF (B) (titer: 1:100). (C) Negative control.
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case_images: PMC11240285_01_fimmu-15-1320608-g002.jpg
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case_images: Subsequent testing for DPPX antibodies using cell-based assays revealed positivity in both the serum (1:1000) and CSF (1:100) ( Figure 2 ).
case_images: Timeline of the clinical course, changes in the MMSE, MoCA, mRS, CD19+ B-cell count, and different treatment regimens of the case.
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case_images: PMC11240285_01_fimmu-15-1320608-g003.jpg
case_images: f3
case_images: Tremors were almost completely alleviated after 5 months ( Figure 3 ).