case_images: PMC11024360_01
case_images: Chest computed tomography (CT), bronchoscopy, and pathological results at admission: (A) Chest CT scan reveals a 60x51mm mass in the right upper lung lobe. (B) Bronchoscopy examination does not show any clear intratracheal abnormalities. (C) Pathological examination of the biopsy specimen (H&E stain, original magnification, x200 times) and PD-L1 immunohistochemical staining (x100 times).
case_images: fonc-14-1370666-g001.jpg
case_images: PMC11024360_01_fonc-14-1370666-g001.jpg
case_images: f1
case_images: Enlarged lymph nodes of the 4R group were noted within the mediastinum, with a short-axis diameter of approximately 1.6 cm ( Figure 1A ). Bronchoscopy revealed no discernible abnormalities ( Figure 1B ).
case_images: Identification of p.G719X (c.2155G>T) in EGFR exon 18 and p.S768I (c.2303G>T) in exon 20 by next-generation sequencing.
case_images: fonc-14-1370666-g002.jpg
case_images: PMC11024360_01_fonc-14-1370666-g002.jpg
case_images: f2
case_images: Next-generation sequencing (NGS) analysis using a panel (Illumina nova 6000 platform) covering 520 cancer-related genes revealed missense mutations in exon 18 [EGFR p.G719X (c.2155G>T, p.Gly719Cys)] and 20 [EGFR p.S768I (c.2303G>T, p.Ser768Ile)] ( Figure 2 ).
case_images: Clinical course of the patient.
case_images: fonc-14-1370666-g003.jpg
case_images: PMC11024360_01_fonc-14-1370666-g003.jpg
case_images: f3
case_images: One month later, the RUL tumor was further reduced to approximately 35x25 mm ( Figure 3 ).