case_images: PMC11401043_01
case_images: First liver biopsy (day 15 after diagnosis): massive fibrosis replacing most of the liver tissue with no inflammation and no signs of leukemia (Masson's trichrome, 20X).
case_images: fonc-14-1441318-g001.jpg
case_images: PMC11401043_01_fonc-14-1441318-g001.jpg
case_images: f1
case_images: A liver biopsy was performed to help guide future chemotherapy and showed massive fibrosis replacing most of the liver tissue with no inflammation or signs of leukemia ( Figure 1 ).
case_images: Repeat liver biopsy (3 months after diagnosis). (A). Focal ballooning degeneration of hepatocytes, bile deposits, no inflammation or leukemic infiltrates (H&E 40X). (B). Minimal sinusoidal fibrosis (Masson's trichrome, 20X).
case_images: fonc-14-1441318-g002.jpg
case_images: PMC11401043_01_fonc-14-1441318-g002.jpg
case_images: f2
case_images: A repeat liver biopsy revealed extensive ballooning degeneration of the hepatocytes ( Figure 2A ), bile deposits, no inflammation or leukemic infiltrates, and minimal fibrosis ( Figure 2B ), indicating drug-induced cholestasis.
case_images: PMC11401043_02