case_images: PMC9614080_01
case_images: Ocular pathological features. (A) the patient's left upper eyelid was red and swollen, the skin lines disappeared, and it was difficult to open his eyes. (B) the patient's upper eyelid can reach a size of about 30 mm x 20 mm mass with unclear boundary, hard quality and poor activity. (C) the patient had bulbar conjunctival congestion, edema and corneal conjunctivalization.
case_images: fsurg-09-1004554-g001.jpg
case_images: PMC9614080_01_fsurg-09-1004554-g001.jpg
case_images: F1
case_images: The upper eyelid of the left eye is red and swollen, the dermatoglyphs disappear, and it is difficult to open the eyes. The upper eyelid can touch a size of about 30 mm  x  20 mm mass with unclear boundary, hard texture, poor activity, obvious tenderness, bulbar conjunctival congestion and edema, corneal conjunctivalization, and other structures cannot be seen clearly; the international standard visual acuity chart was used to check the visual acuity: the naked visual acuity was 0.2 in the right eye and no light perception in the left eye; the intraocular pressure was measured by non-contact tonometer: 11.5 mmHg (1 mmHg = 0.133 kpa) in the right eye and 46.5 mmHg (1 mmHg = 0.133 kpa) in the left eye (Figures 1A-C).
case_images: MRI examination and histopathological verification. (A) MRI examination of the patient's orbit. (B) enhanced MRI of the patient's orbit. (C,D), histopathological verification of tumor tissue in SCC patient.
case_images: fsurg-09-1004554-g002.jpg
case_images: PMC9614080_01_fsurg-09-1004554-g002.jpg
case_images: F2
case_images: It showed that the signal shadow of soft tissue in left diaphragm, inside and outside muscle cone and lacrimal gland area was significantly enhanced, and there was spotted low signal shadow inside, and there were no abnormal enhancement changes in the rest (Figures 2A,B). The postoperative histopathological diagnosis was: (left eye) malignant tumor, consistent with squamous cell carcinoma, with extensive infiltration of cancer tissue into stroma and multifocal necrosis (Figures 2C,D).
case_images: Detection the cell apoptosis by mIHC.
case_images: fsurg-09-1004554-g003.jpg
case_images: PMC9614080_01_fsurg-09-1004554-g003.jpg
case_images: F3
case_images: It was showed that all of the apoptosis markers were extensively expressed in the tumor tissues, which infer to there was ubiquitous apoptosis in tumor tissues (Figure 3).
case_images: Detection the immune cells infiltration by mIHC.
case_images: fsurg-09-1004554-g004.jpg
case_images: PMC9614080_01_fsurg-09-1004554-g004.jpg
case_images: F4
case_images: It was showed that there were lots of CD3, CD4, CD8 and F480 expression in tumor tissues, except for CD11C (Figure 4).