case_images: PMC11830587_01
case_images: Schematic of Radiation Dose Administered and Planning in Pre-Radiotherapy Chest CT. (A) Case 1 (B) Case 2, (C) Case 3.
case_images: fonc-15-1438120-g001.jpg
case_images: PMC11830587_03_fonc-15-1438120-g001.jpg
case_images: f1
case_images: Treatment began with two cycles of cisplatin/etoposide chemotherapy, followed by concurrent chemoradiotherapy (45Gy in 30 [150cGy] fractions BID;  Figure 1C ) with cisplatin for four weeks and prophylactic cranial irradiation. T8 vertebral fracture, with MRI confirming it as an anterior wedging compression fracture ( Supplementary Figure 1 ). The patient was asymptomatic, with no pain or other acute complaints.
case_images: Imaging of Case 1. (A, B) PET-CT scans conducted prior to radiotherapy revealed no evidence of vertebral fractures. (C, D) Follow-up PET-CT scans post-radiotherapy, depicting compression fractures in the T4, T7, and T8 vertebrae, accompanied by diffuse metabolic activity, absent in prior imaging. (E, F) MRI showing the presence of vertebral fractures.
case_images: fonc-15-1438120-g002.jpg
case_images: PMC11830587_01_fonc-15-1438120-g002.jpg
case_images: f2
case_images: T4 and T6-T9 (all within the irradiated field;  Figure 1A ), consistent findings with insufficiency fractures ( Figure 2 ). Treatment involved dorsal epiduroscopy and vertebroplasty with radiofrequency rhizotomy for pain management.
case_images: PMC11830587_02
case_images: Schematic of Radiation Dose Administered and Planning in Pre-Radiotherapy Chest CT. (A) Case 1 (B) Case 2, (C) Case 3.
case_images: fonc-15-1438120-g001.jpg
case_images: PMC11830587_03_fonc-15-1438120-g001.jpg
case_images: f1
case_images: Treatment began with two cycles of cisplatin/etoposide chemotherapy, followed by concurrent chemoradiotherapy (45Gy in 30 [150cGy] fractions BID;  Figure 1C ) with cisplatin for four weeks and prophylactic cranial irradiation. T8 vertebral fracture, with MRI confirming it as an anterior wedging compression fracture ( Supplementary Figure 1 ). The patient was asymptomatic, with no pain or other acute complaints.
case_images: Imaging of Case 2. (A) PET-.CT scans conducted prior to radiotherapy revealed no evidence of vertebral fractures. (B) Follow-up PET-CT scans post-radiotherapy, depicting a compression fracture in the T7 vertebra, accompanied by diffuse metabolic activity, absent in prior imaging. (C) MRI showing the presence of the T7 vertebral fracture. (D) Follow-up PET-CT scan depicting new compression fracture in the T6 vertebra, accompanied by diffuse metabolic activity (E) MRI showing the presence of T6 and T7 compression fractures with anterior wedging.
case_images: fonc-15-1438120-g003.jpg
case_images: PMC11830587_02_fonc-15-1438120-g003.jpg
case_images: f3
case_images: MRI to be inflammatory rather than neoplastic ( Figure 3 ). The patient did report that for the past month, he had had moderate back pain but no history of falls. Management included a corset and T7 vertebroplasty in February 2019 which controlled the pain.
case_images: PMC11830587_03
case_images: Schematic of Radiation Dose Administered and Planning in Pre-Radiotherapy Chest CT. (A) Case 1 (B) Case 2, (C) Case 3.
case_images: fonc-15-1438120-g001.jpg
case_images: PMC11830587_03_fonc-15-1438120-g001.jpg
case_images: f1
case_images: Treatment began with two cycles of cisplatin/etoposide chemotherapy, followed by concurrent chemoradiotherapy (45Gy in 30 [150cGy] fractions BID;  Figure 1C ) with cisplatin for four weeks and prophylactic cranial irradiation. T8 vertebral fracture, with MRI confirming it as an anterior wedging compression fracture ( Supplementary Figure 1 ). The patient was asymptomatic, with no pain or other acute complaints.