case_images: PMC9430984_01
case_images: Cutaneous leiomyomas on patient's back, leading to suspicion of hereditary leiomyomatosis and renal cell cancer (HLRCC).
case_images: JKCVHL-9-027-g001.jpg
case_images: PMC9430984_01_JKCVHL-9-027-g001.jpg
case_images: F1
case_images: After multiple reddish-brown, painful skin nodules appeared on her arms, legs, and back, she had a skin biopsy, which confirmed piloleiomyomas (Figure 1).
case_images: Pathology of RCC. (A) Neoplasm with papillary-predominant pattern, formed by clear cells with an irregular nucleus and a perinucleolar halo. (B) Immunohistochemistry with antibody for fumarate hydratase presents immunoreactivity only in stromal cells, while tumoral cells are negative.
case_images: JKCVHL-9-027-g002.jpg
case_images: PMC9430984_01_JKCVHL-9-027-g002.jpg
case_images: F2
case_images: A computed tomography (CT) scan demonstrated three contrast-enhancing renal tumors of the right kidney, with diameters of 4.9, 4.8, and 1.7 cm (Figure 2).
case_images: Pedigree of the patient.
case_images: JKCVHL-9-027-g003.jpg
case_images: PMC9430984_01_JKCVHL-9-027-g003.jpg
case_images: F3
case_images: The patient's family history also included a brother and other relatives having cutaneous leiomyomas (Figure 3).