case_images: PMC7117631_01
case_images: (A) Ulcerated lesion on the mucosal side of the lower lip. (B) Nodular lesion on the skin.
case_images: NCI-7-187-g001.jpg
case_images: PMC7117631_01_NCI-7-187-g001.jpg
case_images: F1
case_images: However, on the oral mucosal side, the lesion was ulcerative centrally (Fig. 1A, Fig. 1B).
case_images: Bicellular architecture, outer clear polygonal myoepithelial cells and inner cuboidal duct-like cells.
case_images: NCI-7-187-g002.jpg
case_images: PMC7117631_01_NCI-7-187-g002.jpg
case_images: F2
case_images: The tumor showed bicellular architecture, clear polygonal myoepithelial cells and cells forming duct with round central nuclei (Fig. 2).
case_images: EMA staining in ductal cells. On the left side, there is no staining in myoepithelial cells.
case_images: NCI-7-187-g003.jpg
case_images: PMC7117631_01_NCI-7-187-g003.jpg
case_images: F3
case_images: Immunohistochemically, epithelial cells forming duct were positive for EMA (Fig. 3), Pan-CK, CK7, the myoepithelial cells were positive for p63, p40 (Fig. 4), HMWCK (Fig. 5), CK5/6.
case_images: Myoepithelial cells stain with HMWCK at the bottom. In the middle of the figure, ductal cells do not express HMWCK.
case_images: NCI-7-187-g005.jpg
case_images: PMC7117631_01_NCI-7-187-g005.jpg
case_images: F5
case_images: Immunohistochemically, epithelial cells forming duct were positive for EMA (Fig. 3), Pan-CK, CK7, the myoepithelial cells were positive for p63, p40 (Fig. 4), HMWCK (Fig. 5), CK5/6.
case_images: Ki-67 index is 5% in the most intense area.
case_images: NCI-7-187-g006.jpg
case_images: PMC7117631_01_NCI-7-187-g006.jpg
case_images: F6
case_images: Ki-67 index was %5 (Fig. 6) and p53 had wild type expression.
case_images: Verrucous carcinoma. Parakeratosis, acanthosis, verrucous growth pattern, mitosis on the basal and middle layer and minimal loss of polarity are seen. There is no invasion here.
case_images: NCI-7-187-g007.jpg
case_images: PMC7117631_01_NCI-7-187-g007.jpg
case_images: F7
case_images: In two vocal cords, there were verrucous carcinoma (Fig. 7).
case_images: Microinvasion of verrucous carcinoma in the left vocal cord.
case_images: NCI-7-187-g008.jpg
case_images: PMC7117631_01_NCI-7-187-g008.jpg
case_images: F8
case_images: In the left vocal cord, microinvasion was seen (Fig. 8).