case_images: PMC11325453_01
case_images: Coronal T1WI scan (A) showed the tumor mass on the upper pole of the left submandibular gland (blue arow). Axial T2WI-FS (B) showed heterogeneous hyperintense with a hypointense lobulated rim (blue arow). The tumor showed heterogeneous high signal intensity on DWI (C). Axial gadolinium-enhanced T1-weighted image (D) showed heterogeneous enhancement with a hypointense rim. Time-intensity curve (TIC) was progressive ascending type (E, F). Its x-axis represents the time of the enhanced scan, from 0 seconds to 380 seconds, with the extension of time, the curve is on the rise.
case_images: fonc-14-1362090-g001.jpg
case_images: PMC11325453_01_fonc-14-1362090-g001.jpg
case_images: f1
case_images: T2-weighted imaging (T2WI) ( Figure 1B ). The tumor showed heterogeneous high signal intensity on diffusion-weighted imaging (DWI) ( Figure 1C ) and slightly low signal intensity on the apparent diffusion coefficient (ADC) map. The gadolinium-enhanced T1WI showed heterogeneous enhancement with an edge low signal enhancement band ( Figure 1D ), and the time-intensity curve (TIC) was of the progressive ascending type ( Figures 1E, F ). The adjacent submandibular glandular tissue and external carotid artery were compressed.
case_images: Lesion surgically excised. The submandibular mass had a grey and white appearance with multifocal hemorrhagic areas on the cut surface. It was surrounded by tissues similar to capsule (blue arrow) and the attached salivary gland tissue (black arrow) was observed.
case_images: fonc-14-1362090-g002.jpg
case_images: PMC11325453_01_fonc-14-1362090-g002.jpg
case_images: f2
case_images: It was surrounded by tissues similar to the capsule, and the attached salivary gland tissue was observed ( Figure 2 ).
case_images: Microscopic image (A) of the excised specimen showing the tumor was located in the lymph nodes, and residual lymphoid tissue could be seen at the edge (HEx20). The tumor cells were arranged in a fence-like and woven pattern (B) (HEx100). The surrounding area of the tumor was accompanied by significant hyaline degeneration (C) (HEx100). The characteristic morphological asbestos-like fibrous nodules (D) (HEx200). SMA (E) was partially expressed in tumor cells (IHCx200). Cyclin-D1 (F) was diffusely expressed in tumor cells (IHCx200).
case_images: fonc-14-1362090-g003.jpg
case_images: PMC11325453_01_fonc-14-1362090-g003.jpg
case_images: f3
case_images: Immunohistochemical analysis revealed that the tumor cells were partially positive for smooth muscle antibody and diffusely positive for cyclin D1, which was consistent with the manifestations of IPM in the lymph nodes ( Figure 3 ).