case_images: PMC4284984_01
case_images: Nests of poorly differentiated squamous cells with interspersed osteoclastic giant cells. H&E stain, x50.
case_images: CRIPA2014-415328.001.jpg
case_images: PMC4284984_01_CRIPA2014-415328.001.jpg
case_images: fig1
case_images: Microscopically the tumor was composed of infiltrative nests of poorly differentiated nonkeratinizing squamous cell carcinoma (Figure 1).
case_images: Osteoclastic giant cells with bland nuclei and lack of atypia. There is also an accompanying lymphocytic infiltrate. H&E stain, x400.
case_images: CRIPA2014-415328.002.jpg
case_images: PMC4284984_01_CRIPA2014-415328.002.jpg
case_images: fig2
case_images: Interspersed in between these tumor cells were numerous osteoclastic giant cells with abundant eosinophilic cytoplasm devoid of nuclear atypia, hyperchromatism, or mitotic activity; also there was an accompanying lymphocytic infiltrate (Figure 2).
case_images: (a) Reactivity to cytokeratin in the squamous component, lack of reactivity in osteoclastic giant cells. Immunohistochemical stain with anti-CK antibody, x50. (b) Reactivity to P63 in the squamous component, lack of reactivity in osteoclastic giant cells. Immunohistochemical stain with anti-P63 antibody, x50.
case_images: CRIPA2014-415328.003.jpg
case_images: PMC4284984_01_CRIPA2014-415328.003.jpg
case_images: fig3
case_images: CD68, CD20, and CD3. CK and P63 were strongly positive in the squamous component and negative in the osteoclastic giant cells (Figure 3), while Vimentin and CD-68 were strongly positive in the giant cell population and negative in the squamous component (Figure 4).
case_images: (a) Reactivity to CD68 in the giant cell population and lack of reactivity in the squamous component. Immunohistochemical stain with anti-CD68 antibody, x50. (b) Reactivity to Vimentin in the giant cell population and lack of reactivity in the squamous component. Immunohistochemical stain with anti-Vimentin antibody, x50.
case_images: CRIPA2014-415328.004.jpg
case_images: PMC4284984_01_CRIPA2014-415328.004.jpg
case_images: fig4
case_images: CD68, CD20, and CD3. CK and P63 were strongly positive in the squamous component and negative in the osteoclastic giant cells (Figure 3), while Vimentin and CD-68 were strongly positive in the giant cell population and negative in the squamous component (Figure 4).
case_images: Reactivity to CD20 (a) and CD3 (b) showed a reactive pattern of the lymphocytic infiltrate. Immunohistochemical stain with anti-CD20 (a) and anti-CD3 (b) antibodies, x100.
case_images: CRIPA2014-415328.005.jpg
case_images: PMC4284984_01_CRIPA2014-415328.005.jpg
case_images: fig5
case_images: Expression of CD20 and CD3 showed a reactive pattern of the lymphocytic infiltrate (Figure 5).