case_images: PMC10600022_01
case_images: Treatment assessment by abdominal enhanced CT (A-F). (A) Diagnosis, the tumor infiltration depth is classified as T4. (B) PR, after two cycles of XELOX therapy. (C) SD, after four cycles of XELOX therapy. (D) PD, abdominal metastasis. (E) SD-, after four cycles of combination therapy. (F) SD+, after seven cycles of combination therapy. PR, partial response; PD, progressive disease; SD, stable disease.
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case_images: The 41-year-old female patient presented to the clinic with abdominal pain and was diagnosed with colon cancer on January 16, 2020 ( Figure 1A ). The XELOX regimen was utilized for therapy, which was then followed by 2 cycles of treatment with a PR efficacy evaluation ( Figure 1B ). Subsequently, 4 cycles of treatment were given with an efficacy evaluation of SD ( Figure 1C ). On December 9, 2021, a mass located in the right upper quadrant of the anterior abdominal wall was observed during the reexamination of an abdominal enhanced CT ( Figure 1D ). The patient received four cycles of treatment with an efficacy evaluation of SD- ( Figure 1E ) and seven cycles of treatment with an efficacy evaluation of SD+ ( Figure 1F ).
case_images: (A) Histopathology of SCC of transverse colon (HEx100). (B) Immunohistochemistry (IHC) of the Abdominal nodule biopsies.
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case_images: The postoperative pathological examination yielded a poorly differentiated SCC located in the colon ( Figure 2A ). Genetic testing revealed a mutation in the TP53 gene, but RAS and BRAF were wild-type, and IHC indicated that the patient had PD-L1: CPS (Combined Positive Score) = 20 ( Figure 2B ).
case_images: Treatment summary of the patient from diagnosis to last follow-up. PR, partial response; PD, progressive disease; SD, stable disease.
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case_images: Regrettably, the patient passed away on June 9, 2023. ( Figure 3 ).