case_images: PMC11091244_01
case_images: (A, B) Contrast-enhanced computed tomography scan of the abdomen revealing a poorly-defined, mixed-density lesion (7.0 cm x 7.1 cm) with internal enhancement involving the right hepatic lobe, initially considered as hepatic malignancy.
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case_images: PMC11091244_01_fimmu-15-1376276-g001.jpg
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case_images: Contrast-enhanced computed tomography (CT) of the abdomen revealed a poorly-defined, mixed-density lesion (7.0 cm x 7.1 cm) with internal enhancement involving the right hepatic lobe, suggestive of hepatic malignancy ( Figure 1 ). Immunohistochemically, the inflammatory cells stained diffusely positive for CD38 and Mum-1 ( Supplementary Figures 1A, B ), indicative of plasma cells. Additionally, the hepatic lesion displayed focal positivity for IgG4 [> 10 plasma cells/high-power field(HPF)] ( Supplementary Figures 1C, D ), with a ratio of IgG4/IgG plasma cells exceeding 40%, meeting the criteria for classification as an IgG4-related disease.
case_images: (A, B) Magnetic resonance imaging (MRI) of the abdomen displaying a 10 cm x 7.6 cm, contrast-enhancing, poorly defined, large-sized lesion involving the right hepatic lobe, also initially considered as hepatic malignancy.
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case_images: (A, B) Microscopic image of the focal hepatic lesion showing a mixture of inflammatory cells in a background of dense fibrous tissues (HE stain, magnification power: x200).
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case_images: Histopathological analysis revealed dense fibrous tissue around the portal area in storiform, along with a mixture of inflammatory cells and eosinophil infiltration in the portal area ( Figure 3 ).
case_images: Microscopic picture of the focal hepatic lesion displaying obliterating phlebitis (He stain, magnification power, x200).
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case_images: f4
case_images: Obliterating phlebitis was observed, while lymphoid follicles were absent ( Figure 4 ).