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case_images: Right anterior oral tongue lesion at initial presentation.
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case_images: Physical examination revealed a 2.5-cm ulcerative lesion of the anterior right oral tongue with central necrosis, with palpable deep extension of abnormal tissue to the midline (Figure 1).
case_images: PET/CT imaging demonstrating a hypermetabolic lesion of the right anterior tongue (arrow). CT indicates computed tomography; PET, positron emission tomography.
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case_images: A positron emission tomography (PET)/computed tomography (CT) scan was performed confirming the right tongue lesion (Figure 2), and mildly hypermetabolic right level II nodes were visualized.
case_images: H&E stain of right anterior oral tongue mass demonstrating mitotically active infiltrating nests of epithelioid cells (arrows).
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case_images: These cells demonstrated a high degree of cellular atypia with eccentrically placed nuclei with prominent nucleoli and dense pink cytoplasm (Figure 3), which combined with the infiltrative growth pattern confirmed a malignant tumor.
case_images: Immunohistochemistry demonstrating positivity for pancytokeratin (arrows).
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case_images: Immunohistochemical stains demonstrated positivity for pancytokeratin (Figure 4), epithelial membrane antigen (EMA) (Figure 5), calponin (Figure 6), and glial fibrillary acidic protein (GFAP) (Figure 7), consistent with myoepithelial differentiation.
case_images: Immunohistochemistry demonstrating positivity for epithelial membrane antigen (EMA).
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case_images: Immunohistochemical stains demonstrated positivity for pancytokeratin (Figure 4), epithelial membrane antigen (EMA) (Figure 5), calponin (Figure 6), and glial fibrillary acidic protein (GFAP) (Figure 7), consistent with myoepithelial differentiation.
case_images: Immunohistochemistry demonstrating positivity for calponin (arrows).
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case_images: Immunohistochemical stains demonstrated positivity for pancytokeratin (Figure 4), epithelial membrane antigen (EMA) (Figure 5), calponin (Figure 6), and glial fibrillary acidic protein (GFAP) (Figure 7), consistent with myoepithelial differentiation.
case_images: Immunohistochemistry demonstrating positivity for glial fibrillary acidic protein (arrows).
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case_images: Immunohistochemical stains demonstrated positivity for pancytokeratin (Figure 4), epithelial membrane antigen (EMA) (Figure 5), calponin (Figure 6), and glial fibrillary acidic protein (GFAP) (Figure 7), consistent with myoepithelial differentiation.
case_images: Three-month postoperative photograph demonstrating well-healed surgical site and no evidence of residual disease at primary site.
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case_images: Physical examination and indirect flexible nasopharyngolaryngoscopy were normal, with a well-healed surgical defect (Figure 8).