case_images: PMC2823050_01
case_images: Enhanced abdominal CT scan shows an enlarged spleen with multiple low attenuated nodular lesions and liver cirrhosis featuring a nodular surface, heterogeneous density and mild atrophy of the left lobe.
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case_images: PMC2823050_01_ymj-46-184-g001.jpg
case_images: F1
case_images: The abdominal computed tomography (CT) scan showed splenomegaly with the multiple hypodense nodules of different sizes and liver cirrhosis featuring a nodular surface, heterogeneous density and mild atrophy of the left lobe (Fig. 1).
case_images: A. T2-weighted abdominal magnetic resonance image shows multiple splenic nodules with high signal intensity. B. T1-weighted abdominal magnetic resonance image shows multiple splenic nodules with iso to low-signal intensity.
case_images: ymj-46-184-g002.jpg
case_images: PMC2823050_01_ymj-46-184-g002.jpg
case_images: F2
case_images: The splenomegaly, with multiple nodules and liver cirrhosis, were found on abdominal MRI (Fig. 2).
case_images: The multiple circumscribed blood-filled spongy nodules of 0.2 to 0.6 cm in size located within the spleen that weighed 370 g. The capsule was intact and tensile, with a vaguely micronodular surface. The cut surface of the spleen was a dark purple color and beef-like soft.
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case_images: PMC2823050_01_ymj-46-184-g003.jpg
case_images: F3
case_images: On the serial sections, there were multiple circumscribed blood-filled spongy like nodules of 0.2 to 0.6 cm in size (Fig. 3).
case_images: Anastomosing vascular channels with a pseudopapillary pattern and exfoliated cells present in the luminal spaces of the vascular channels (H & E stain, x 400).
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case_images: F4
case_images: The luminal spaces of the vascular channels contained exfoliated cells (Fig. 4).
case_images: Immunohistochemical staining of the splenic nodules. A. Positive staining for the Factor VIII. B. Positive staining for CD31. C. Positive staining for CD68. D. Negative staining for CD34.
case_images: ymj-46-184-g005.jpg
case_images: PMC2823050_01_ymj-46-184-g005.jpg
case_images: F5
case_images: The immunohistochemical staining of the lining cells showed positive for Factor VIII, CD31 and CD68, and negative for CD34 (Fig. 5).