case_images: PMC10067717_01
case_images: Clinical manifestations of Case 1. (A) Both eyes showed conjunctival hyperemia, corneal ulceration, deep stromal infiltration, borderline ambiguity, and opacity. (B) On day 7, the corneal ulcers in both eyes gradually healed, and the conjunctival congestion was reduced. (C) On day 14, the corneal ulcers healed in both eyes. (D) On day 40, conjunctival hyperemia (-) occurred in both eyes, the corneal epithelium was intact, and corneal leukoplakia formed. (E) Tongue and lip defects and oral ulcers.
case_images: fgene-14-1139161-g001.jpg
case_images: PMC10067717_01_fgene-14-1139161-g001.jpg
case_images: F1
case_images: The corneal ulcers infiltrated the deep stromal layer with an unclear borderline (Figure 1A). The chronic oral ulcer had caused profound defects of tongue and lip (Figure 1E). The patient's condition gradually stabilized, and the fever was controlled (Figure 1B). After 2 weeks, systemic medication was gradually stopped, and the corneal and oral ulcers gradually healed (Figure 1C). The cornea remained stable 4 weeks after discharge (Figure 1D).
case_images: PMC10067717_02
case_images: Clinical manifestations of Case 2. (A,B) Conjunctival hyperemia, corneal ulcer; (C) tongue and lip defects and oral ulcers.
case_images: fgene-14-1139161-g002.jpg
case_images: PMC10067717_02_fgene-14-1139161-g002.jpg
case_images: F2
case_images: The ophthalmic examination showed that the corneal reflex disappeared, tear secretion decreased, conjunctival congestion was present in both eyes, and both eyes showed corneal opacity (Figure 2A,B). Her tongue and lip were defective (Figure 2C).