case_images: PMC11627307_01
case_images: Serous tubal intraepithelial carcinoma located in the right fimbriated end of patient 1 showing a focus of atypical epithelial cells with enlarged nuclei, nuclear pleomorphism, pseudo stratification, and prominent nucleoli. (A). Serous tubal intraepithelial carcinoma of patient 1 at higher magnification (B). Immunohistochemistry with a p53 overexpression pattern of serous tubal intraepithelial carcinoma of patient 1 (C). An increased Ki-67 index of serous tubal intraepithelial carcinoma of patient 1 (26%) (D).
case_images: pgp-44-94-g001.jpg
case_images: PMC11627307_01_pgp-44-94-g001.jpg
case_images: F1
case_images: The foci both showed overexpression of p53 and increased Ki-67 index (26%), consistent with STIC (Fig. 1).
case_images: PMC11627307_02
case_images: Serous tubal intraepithelial carcinoma located in the left fimbriated end of patient 2 showing atypical epithelial cells with enlarged, irregular nuclei (A). Serous tubal intraepithelial carcinoma of patient 2 at higher magnification B). Immunohistochemistry with a p53 null-mutation pattern of serous tubal intraepithelial carcinoma of patient 2 (C). An increased Ki-67 index of serous tubal intraepithelial carcinoma of patient 2 (34%) (D).
case_images: pgp-44-94-g002.jpg
case_images: PMC11627307_02_pgp-44-94-g002.jpg
case_images: F2
case_images: However, the fimbriated end of the left fallopian tube showed 2 foci of atypical epithelial cells with enlarged, irregular nuclei with a null-mutation pattern of p53 and an increased Ki-67 index (34%), characterized as STIC (Fig. 2).