case_images: PMC9938402_01
case_images: Endoscopic findings. Three small hyperplastic polyps (a) and no mucosal atrophy (b) 3 years before the referral. c, d Hyperplastic polyps at the greater curvature of the angulus at the referral. e, f Background mucosa showed corpus-dominant gastric atrophy and sticky adherent mucous at the referral.
case_images: crg-2022-0017-0001-529151_f1.jpg
case_images: PMC9938402_01_crg-2022-0017-0001-529151_f1.jpg
case_images: F1
case_images: Previous upper gastrointestinal endoscopy (GIE), performed 3 years prior, revealed three small hyperplastic polyps and mild mucosal atrophy (Fig. 1a, b). At the time of referral, all three polyps had enlarged to approximately 10 mm (Fig. 1c, d). In addition, severe mucosal atrophy in the corpus, mild atrophy in the antral area, and sticky adherent mucous were observed (Fig. 1e, f).
case_images: Histopathological findings of biopsy samples from greater curvature of the corpus. Hematoxylin and eosin staining showed decreased parietal cells and diffuse lymphocytic infiltration of the deep lamina propria (a: x20, b: x100). Immunohistochemistry revealed chromogranin A-positive ECM and enterochromaffin-like cell (ECL) hyperplasia (c: x40, d: x100).
case_images: crg-2022-0017-0001-529151_f2.jpg
case_images: PMC9938402_01_crg-2022-0017-0001-529151_f2.jpg
case_images: F2
case_images: Biopsy samples were taken from the gastric body, and pathological examination showed a decrease in parietal cells compared to normal mucosa and diffuse lymphocytic infiltration of the deep lamina propria with hematoxylin and eosin staining (Fig. 2a, b). A-positive endocrine cell micronest and enterochromaffin-like cell hyperplasia (Fig. 2c, d). A blood test revealed positive
case_images: Gross photograph and histopathological findings of a polyp. a Gross photograph. Hematoxylin and eosin staining showed elongated, branched, dilated foveolar epithelium and edematous inflamed stroma (b: x20, c: x40, d: x100).
case_images: crg-2022-0017-0001-529151_f3.jpg
case_images: PMC9938402_01_crg-2022-0017-0001-529151_f3.jpg
case_images: F3
case_images: The sizes of the polyps were 13 mm x 10 mm x 10 mm, 15 mm x 10 mm x 10 mm, and 16 mm x 13 mm x 10 mm (Fig. 3a). Additionally, edema and cell infiltration were found in the stroma, and no malignant lesions or adenomas were detected in any of the samples (Fig. 3b-d).