case_images: PMC4376512_01
case_images: Fixed drug eruption involving the trunk and extremities.
case_images: 40200_2015_145_Fig1_HTML.jpg
case_images: PMC4376512_01_40200_2015_145_Fig1_HTML.jpg
case_images: Fig1
case_images: On muco-cutaneous examination, multiple circumscribed erythematous and hyperpigmented round macules were present over the lips, trunk and the extremities whereas the oral and genital mucosae showed the presence of well defined erosions (Figure 1).
case_images: Histopathology (H&E) showing band like inflammatory infiltrate, perivascular infiltrate and pigment incontinence.
case_images: 40200_2015_145_Fig2_HTML.jpg
case_images: PMC4376512_01_40200_2015_145_Fig2_HTML.jpg
case_images: Fig2
case_images: A skin biopsy was performed and the histopathological examination revealed a dense band like lymphocytic infiltrate, perivascular inflammatory infiltrate, eosinophils and increased pigment incontinence suggestive of fixed drug eruption (Figure 2).
case_images: Increased erythema over pre-existing hyperpigmented lesions after oral provocation test.
case_images: 40200_2015_145_Fig3_HTML.jpg
case_images: PMC4376512_01_40200_2015_145_Fig3_HTML.jpg
case_images: Fig3
case_images: After another two weeks, patient was administered Sitagliptin 50 mg and within six hours of administration, there was recurrence of lesions in the form of itching and erythema over the residual pigmented lesions (Figure 3).