case_images: PMC10704599_01
case_images: PET-CT results of patients at different time. On August 27, 2020, (A, B) multiple lymph nodes in the right axilla were enlarged, with a large diameter of about 1.5 cm, SUVmax: 9.1; (C) 3.7 cm x 3.8 cm tumor was seen in the right breast nipple, SUVmax: 22.4; (D-F) after four cycles of treatment (November 20, 2020), the right breast tumor and axillary lymph nodes were smaller than before.
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case_images: Figure 1 ), achieving the best response of partial response (PR). For economic reasons, the patient discontinued treatment on their own accord.
case_images: The curative effect of RC48 treatment. (A) After RC48 treatment, the tumor rupture was smaller than before. (B) CT efficacy evaluation after 6 cycles of RC48 treatment. (a-c) Patient status before RC48 treatment; (d-f) after RC48 treatment, the breast tumor and bilateral axillary lymph nodes were significantly reduced.
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case_images: During the treatment period, the ulcerated tumor gradually healed ( Figure 2A ), the patient tolerated the treatment well, and no obvious adverse reactions occurred. After six cycles, a chest CT scan showed that the breast tumor and bilateral axillary lymph nodes had significantly reduced in size, with the best response of PR ( Figure 2B ).
case_images: The improvement of patient's life quality and postoperative immunohistochemical results of right breast cancer after RC48 treatment, as well as the CT results after half a year (July 12, 2023). (A) The five functional areas and overall health level of patients were significantly improved, and the quality of life was significantly improved. (B) The postoperative immunohistochemical results of right breast cancer. (a) ER (2 + 60%), (b) PR (5%), (c) HER2 (2 +), (d) Ki67 proliferation index (60%). (C) The patient 's CT results showed no enlarged lymph nodes, and the condition was stable.
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case_images: After using RC48, the patient experienced significant improvements in the five functional areas and overall health compared to their previous quality of life ( Figure 3A ). Immunohistochemical results for the right breast lesions showed: ER (2 + 60%), PR (+ 5%), HER2 (2+), and Ki67 (60%) ( Figure 3B ); HER2 FISH was positive. The CT results showed that the right breast was changed after operation ( Figure 3C ).