case_images: PMC11783480_01
case_images: Pathology and imaging information for case 2 with timeline. (a) The tumor tissue is arranged in solid sheets and nests, displaying basaloid morphology (HE staining with magnification x40). (b) The basaloid tumor cells have scant cytoplasm, resulting in a high nuclear-to-cytoplasmic ratio. The nuclei exhibit vacuolation and prominent nucleoli, with frequent mitotic figures observed (HE staining with magnification x100). (c) The tumor cells show a loss of SMARCB1/INI-1 expression, with nuclear positivity in stromal cells serving as an internal control (immunohistochemical staining with magnification x200). (d) Primary lesions on MRI T1-weighted image at recurrence (arrow); (e) primary lesions on MRI T2-weighted image at recurrence (arrow); (f, g) pulmonary metastases on CT at recurrence (arrow); (h) primary lesions reaching PR on MRI T1-weighted image after 2 cycles of first-line treatment (arrow); (i) primary lesions reaching PR on MRI T2-weighted image after 2 cycles of first-line treatment (arrow); (j, k) Pulmonary metastases reaching PR on CT after 2 cycles of first-line treatment.
case_images: 10.1177_00368504251315075-fig1.jpg
case_images: PMC11783480_05_10.1177_00368504251315075-fig1.jpg
case_images: fig1-00368504251315075
case_images: In October 2023, the patient presented with "distension and blurred vision in the right eye." MR reexamination showed a mixed signal shadow in the nasal cavity measuring 52 x 38 mm (Figure 1(d) and (e)). Lung CT showed multiple solid nodules in both lungs (Figure 1(f) and (g)), suggesting tumor recurrence and metastasis. MR performed after two cycles of treatment showed a significant reduction in intranasal mass (Figure 1(h) and (i)) and pulmonary metastasis (Figure 1(j) and (k)), and the efficacy of immunotherapy was evaluated as partial response (PR).
case_images: PMC11783480_02
case_images: Pathology and imaging information for case 2 with timeline. (a) The tumor tissue is arranged in solid sheets and nests, displaying basaloid morphology (HE staining with magnification x40). (b) The basaloid tumor cells have scant cytoplasm, resulting in a high nuclear-to-cytoplasmic ratio. The nuclei exhibit vacuolation and prominent nucleoli, with frequent mitotic figures observed (HE staining with magnification x100). (c) The tumor cells show a loss of SMARCB1/INI-1 expression, with nuclear positivity in stromal cells serving as an internal control (immunohistochemical staining with magnification x200). (d) Primary lesions on MRI T1-weighted image at recurrence (arrow); (e) primary lesions on MRI T2-weighted image at recurrence (arrow); (f, g) pulmonary metastases on CT at recurrence (arrow); (h) primary lesions reaching PR on MRI T1-weighted image after 2 cycles of first-line treatment (arrow); (i) primary lesions reaching PR on MRI T2-weighted image after 2 cycles of first-line treatment (arrow); (j, k) Pulmonary metastases reaching PR on CT after 2 cycles of first-line treatment.
case_images: 10.1177_00368504251315075-fig1.jpg
case_images: PMC11783480_05_10.1177_00368504251315075-fig1.jpg
case_images: fig1-00368504251315075
case_images: In October 2023, the patient presented with "distension and blurred vision in the right eye." MR reexamination showed a mixed signal shadow in the nasal cavity measuring 52 x 38 mm (Figure 1(d) and (e)). Lung CT showed multiple solid nodules in both lungs (Figure 1(f) and (g)), suggesting tumor recurrence and metastasis. MR performed after two cycles of treatment showed a significant reduction in intranasal mass (Figure 1(h) and (i)) and pulmonary metastasis (Figure 1(j) and (k)), and the efficacy of immunotherapy was evaluated as partial response (PR).
case_images: PMC11783480_03
case_images: Pathology and imaging information for case 2 with timeline. (a) The tumor tissue is arranged in solid sheets and nests, displaying basaloid morphology (HE staining with magnification x40). (b) The basaloid tumor cells have scant cytoplasm, resulting in a high nuclear-to-cytoplasmic ratio. The nuclei exhibit vacuolation and prominent nucleoli, with frequent mitotic figures observed (HE staining with magnification x100). (c) The tumor cells show a loss of SMARCB1/INI-1 expression, with nuclear positivity in stromal cells serving as an internal control (immunohistochemical staining with magnification x200). (d) Primary lesions on MRI T1-weighted image at recurrence (arrow); (e) primary lesions on MRI T2-weighted image at recurrence (arrow); (f, g) pulmonary metastases on CT at recurrence (arrow); (h) primary lesions reaching PR on MRI T1-weighted image after 2 cycles of first-line treatment (arrow); (i) primary lesions reaching PR on MRI T2-weighted image after 2 cycles of first-line treatment (arrow); (j, k) Pulmonary metastases reaching PR on CT after 2 cycles of first-line treatment.
case_images: 10.1177_00368504251315075-fig1.jpg
case_images: PMC11783480_05_10.1177_00368504251315075-fig1.jpg
case_images: fig1-00368504251315075
case_images: In October 2023, the patient presented with "distension and blurred vision in the right eye." MR reexamination showed a mixed signal shadow in the nasal cavity measuring 52 x 38 mm (Figure 1(d) and (e)). Lung CT showed multiple solid nodules in both lungs (Figure 1(f) and (g)), suggesting tumor recurrence and metastasis. MR performed after two cycles of treatment showed a significant reduction in intranasal mass (Figure 1(h) and (i)) and pulmonary metastasis (Figure 1(j) and (k)), and the efficacy of immunotherapy was evaluated as partial response (PR).
case_images: PMC11783480_04
case_images: PMC11783480_05
case_images: Pathology and imaging information for case 2 with timeline. (a) The tumor tissue is arranged in solid sheets and nests, displaying basaloid morphology (HE staining with magnification x40). (b) The basaloid tumor cells have scant cytoplasm, resulting in a high nuclear-to-cytoplasmic ratio. The nuclei exhibit vacuolation and prominent nucleoli, with frequent mitotic figures observed (HE staining with magnification x100). (c) The tumor cells show a loss of SMARCB1/INI-1 expression, with nuclear positivity in stromal cells serving as an internal control (immunohistochemical staining with magnification x200). (d) Primary lesions on MRI T1-weighted image at recurrence (arrow); (e) primary lesions on MRI T2-weighted image at recurrence (arrow); (f, g) pulmonary metastases on CT at recurrence (arrow); (h) primary lesions reaching PR on MRI T1-weighted image after 2 cycles of first-line treatment (arrow); (i) primary lesions reaching PR on MRI T2-weighted image after 2 cycles of first-line treatment (arrow); (j, k) Pulmonary metastases reaching PR on CT after 2 cycles of first-line treatment.
case_images: 10.1177_00368504251315075-fig1.jpg
case_images: PMC11783480_05_10.1177_00368504251315075-fig1.jpg
case_images: fig1-00368504251315075
case_images: In October 2023, the patient presented with "distension and blurred vision in the right eye." MR reexamination showed a mixed signal shadow in the nasal cavity measuring 52 x 38 mm (Figure 1(d) and (e)). Lung CT showed multiple solid nodules in both lungs (Figure 1(f) and (g)), suggesting tumor recurrence and metastasis. MR performed after two cycles of treatment showed a significant reduction in intranasal mass (Figure 1(h) and (i)) and pulmonary metastasis (Figure 1(j) and (k)), and the efficacy of immunotherapy was evaluated as partial response (PR).
case_images: PMC11783480_06
case_images: PMC11783480_07
case_images: PMC11783480_08