case_images: PMC3709382_01
case_images: ThinPrep Pap smear, case 1 (Papanicolaou stain, x60). Groups of columnar shaped cells showing cytomorphological features of malignancy including increased nuclear to cytoplasmic ratio, nuclear pleomorphism, hyperchromasia, and prominent nucleoli
case_images: CJ-10-9-g001.jpg
case_images: PMC3709382_01_CJ-10-9-g001.jpg
case_images: F1
case_images: Mixed inflammatory cells and squamous cells were present in the background [Figure 1].
case_images: ThinPrep Pap smear, case 2 (Papanicolaou stain, x60). Syncytial fragments of cells showing cytomorphological features of malignancy including increased nuclear to cytoplasmic ratio, nuclear pleomorphism, hyperchromasia, and prominent nucleoli
case_images: CJ-10-9-g002.jpg
case_images: PMC3709382_01_CJ-10-9-g002.jpg
case_images: F2
case_images: In the second case, the TP Pap smear showed tumor cells present in syncytial fragments of tumor cells with enlarged ovoid nuclei, increased nuclear to cytoplasmic ratio, nuclear pleomorphism, hyperchromasia, and prominent nucleoli [Figure 2].
case_images: Immunocytochemical results, case 2. cytokeratin 7-, cytokeratin 20+ and caudal-related homeobox 2+ immunostaining pattern (x20)
case_images: CJ-10-9-g003.jpg
case_images: PMC3709382_01_CJ-10-9-g003.jpg
case_images: F3
case_images: For the second case, ICC showed immunoreactivity in the tumor cells for cytoplasmic CK20 and nuclear CDX2, while the tumor cells were non-immunoreactive for CK7 [Figure 3].
case_images: Vaginal biopsy, case 1 (H and E, x10), Malignant glands infiltrating the vaginal stroma. cytokeratin 7-, cytokeratin 20+ and caudal-related homeobox 2+ immunohistochemical staining pattern (x10)
case_images: CJ-10-9-g004.jpg
case_images: PMC3709382_01_CJ-10-9-g004.jpg
case_images: F4
case_images: The vaginal biopsies showed metastatic colorectal carcinoma infiltrating the vaginal tissue [Figure 4].