case_images: PMC9507790_01
case_images: PMC9507790_02
case_images: PMC9507790_03
case_images: PMC9507790_04
case_images: This figure depicts the malformed great toes of patient 2's baby. Based on physical exam, there was high clinical suspicion for FOP, and subsequent testing for the ACVR1/ALK2 gene mutation confirmed a diagnosis of classic FOP.
case_images: CRIOG2022-9857766.001.jpg
case_images: PMC9507790_04_CRIOG2022-9857766.001.jpg
case_images: fig1
case_images: Her infant was diagnosed with classic FOP based on malformed great toes and confirmatory genetic testing (Figure 1).
case_images: This image is a 3D model of patient 3's computed tomographic chest scan performed at the time of her initial presentation to our care. The sternum is absent to allow for visualization of the path of the spine, which is depicted in purple. Heterotopic bone formation is portrayed in red.
case_images: CRIOG2022-9857766.002.jpg
case_images: PMC9507790_04_CRIOG2022-9857766.002.jpg
case_images: fig2
case_images: An 18 yo G2P0010 with classic FOP, severe restrictive pulmonary disease, chronic hypertension, and seizure disorder, presented to our care at 15 weeks gestation (Figure 2).
case_images: PMC9507790_05
case_images: PMC9507790_06
case_images: This figure depicts the feet of the baby born to patient 3 in this case series. The great toes appear normal. Genetic testing was performed immediately following delivery and revealed absence of the ACVR1/ALK2 gene mutation.
case_images: CRIOG2022-9857766.003.jpg
case_images: PMC9507790_06_CRIOG2022-9857766.003.jpg
case_images: fig3
case_images: Her infant had an uncomplicated course; his great toes were normal, and genetic testing ruled-out a diagnosis of FOP (Figure 3).