case_images: PMC6119272_01
case_images: Summarizing scheme of disease progress
case_images: 12878_2018_114_Fig1_HTML.jpg
case_images: PMC6119272_01_12878_2018_114_Fig1_HTML.jpg
case_images: Fig1
case_images: Ophthalmoscopy of the right eye revealed papillary edema, retinal hemorrhages (Roth's spots) and arteriovenous nickings (for further details see Fig. 1 and Table 1).
case_images: Bone marrow smears of an acute myeloid leukemia without maturation case showing numerous blasts with round nuclei, fine nuclear chromatin, and dark blue cytoplasm (Leishman stain, oil immersion x 100)
case_images: 12878_2018_114_Fig2_HTML.jpg
case_images: PMC6119272_01_12878_2018_114_Fig2_HTML.jpg
case_images: Fig2
case_images: Bone marrow (BM) aspiration revealed 70% of blasts (Fig. 2).
case_images: GTG-banding revealed a hyperdiploid karyotype multiple numerical and or structural rearrangements
case_images: 12878_2018_114_Fig3_HTML.jpg
case_images: PMC6119272_01_12878_2018_114_Fig3_HTML.jpg
case_images: Fig3
case_images: 48-50,X,- X,der(1)t(1;2)(?;?),der(1)t(1;3)(?;?),+ 4,+ 4,+ 4,+ 6,t(8;11)(?;?),t(10;12)(?;?),dic(12;17)(?;?)x 2 (Fig. 3), which was further specified by molecular cytogenetic studies (Figs. 4 and 5).
case_images: aCGH characterized losses in 17p13.3-17p11.2 and 17q11.2-17q11.2 regions and gains in 17p11.2-17p11.1, 17q11.1-17q11.2 and 17q11.2-17q12.2 regions. These observations were compatible with the FISH results and their locations according to the Genome Reference Consortium human genome (build 37) (GRCh37)/Human Genome Issue 19 (available from https://genome.ucsc.edu)
case_images: 12878_2018_114_Fig6_HTML.jpg
case_images: PMC6119272_01_12878_2018_114_Fig6_HTML.jpg
case_images: Fig6
case_images: The aCGH analysis revealed different genomic imbalances (Fig. 6).
case_images: GTG-banding in secondary AML-M6 revealed a tetraploid karyotype in 20% of the analyzed cells
case_images: 12878_2018_114_Fig7_HTML.jpg
case_images: PMC6119272_01_12878_2018_114_Fig7_HTML.jpg
case_images: Fig7
case_images: GTG-banding secondary AML-M6 revealed a hyperdiploid karyotype in 10% of the analyzed cells
case_images: 12878_2018_114_Fig8_HTML.jpg
case_images: PMC6119272_01_12878_2018_114_Fig8_HTML.jpg
case_images: Fig8