case_images: PMC5985599_01
case_images: (a) Hematoxylin and eosin stain (40x magnification) from the first, atypical
  meningioma showed a highly cellular tumor with large nuclei and prominent
  nucleoli, and an increased mitotic count. (b) The tumor showed a varying
  expression pattern for EMA (20x magnification). (c) SSTR2A showed diffuse
  and strong membranous and cytoplasmic positivity (20x magnification). (d)
  MDM2 amplification resulted in MDM2 overexpression, since additional
  immunohistochemistry showed nuclear positivity for MDM2 (40x
  magnification).
case_images: 10.1177_2036361318779511-fig1.jpg
case_images: PMC5985599_01_10.1177_2036361318779511-fig1.jpg
case_images: fig1-2036361318779511
case_images: Organization (WHO) grade II was made (Figure 1). One year later, MRI showed subdural relapse of the tumor at the same location.
case_images: a) Hematoxylin and eosin stain (40x magnification) from the recurrent,
  anaplastic meningioma showed a frankly malignant tumor with prominent
  cytological atypia, high mitotic count, and extensive necrosis. (b) The
  tumor showed only partial positivity for EMA (20x magnification). (c) SSTR2A
  showed membranous and cytoplasmic positivity in the majority of the tumor
  (40x magnification). (d) MDM2 amplification resulted in MDM2 overexpression,
  since additional immunohistochemistry showed nuclear positivity for MDM2
  (40x magnification).
case_images: 10.1177_2036361318779511-fig2.jpg
case_images: PMC5985599_01_10.1177_2036361318779511-fig2.jpg
case_images: fig2-2036361318779511
case_images: The diagnosis was anaplastic meningioma, WHO grade III (Figure 2).
case_images: Representative FISH images from the first, atypical meningioma. (a)
  Amplification of CDK4 gene, as indicated by the multiple green signals from
  the Spectrum-Green (SG)-labeled, telomeric to DDIT3/12q13 probe (which
  covers CDK4 gene) in reference to the Spectrum-Orange (SO)-labeled,
  centromeric to DDIT3/12q13 probe. (b) Amplification of MDM2 gene, as
  indicated by the multiple red signals from the SO-labeled MDM2/12q14
  loci-specific probe in reference to the SG-labeled chromosome 12 centromeric
  probe.
case_images: 10.1177_2036361318779511-fig3.jpg
case_images: PMC5985599_01_10.1177_2036361318779511-fig3.jpg
case_images: fig3-2036361318779511
case_images: FISH also showed gross CDK4 amplification in 73% and gross MDM2 amplification in 76% of the tumor cells from the first, atypical meningioma (Figure 3).