case_images: PMC10601816_01
case_images: Radiological response to treatment with larotrectinib. a Pretherapeutic CT image demonstrating pleural effusion left. b CT scan shows CR after 8 weeks with pleural drainage in situ (red arrow). c CT scan shows persistent CR after 14 weeks. CT, computed tomography.
case_images: cro-2023-0016-0001-533572_F01.jpg
case_images: PMC10601816_01_cro-2023-0016-0001-533572_F01.jpg
case_images: F1
case_images: A 51-year-old female never-smoker patient presented with progressive shortness of breath and new left-sided pleural effusion in September 2022 (shown in Fig. 1).
case_images: Clinical course. CT, computed tomography; CR, complete response (CT scan); wk, week.
case_images: cro-2023-0016-0001-533572_F02.jpg
case_images: PMC10601816_01_cro-2023-0016-0001-533572_F02.jpg
case_images: F2
case_images: As a result, the therapy had to be interrupted again (shown in Fig. 2) and even after renewed start with 20% of dose, a consecutive ALT increase occurred; therefore, treatment was permanently discontinued and a trial of treatment with entrectinib was instead initiated.