case_images: PMC8576382_01
case_images: Right carotid body of Case 1 - Haematoxylin-eosin (A) and immunohistochemitries for CD61 (B; arrows: fibrin/platelet microthrombosis), nucleocapsid (C), Spike (D), CD68 (E) and CD3 (F). Scale bars: 100 microm (A, B); 50 microm (C-F).
case_images: fimmu-12-736529-g001.jpg
case_images: PMC8576382_01_fimmu-12-736529-g001.jpg
case_images: f1
case_images: The right (Figure 1) and left (Supplementary Figure 2) CBs showed severe blood congestion of microvasculature, with some small CD61-positive platelet thrombi.
case_images: Right carotid body of Case 2 - Haematoxylin-eosin (A) and immunohistochemitries for CD61 (B), nucleocapsid (C; arrows: positive cells), Spike (D), CD68 (E) and CD3 (F). Scale bars: 100 microm (A); 50 microm (B-F). Inserts: high magnification of positive type I cells; Scale Bar: 15 microm.
case_images: fimmu-12-736529-g002.jpg
case_images: PMC8576382_01_fimmu-12-736529-g002.jpg
case_images: f2
case_images: The right (Figure 1) and left (Supplementary Figure 2) CBs showed severe blood congestion of microvasculature, with some small CD61-positive platelet thrombi. In this case (Figure 2), some small CD61-positive platelet thrombi were also found in the vessels of the CB, in the presence of moderate congestion.
case_images: Right carotid body of Case 3 - Haematoxylin-eosin (A) and immunohistochemitries for nucleocapsid (B,C; arrows: positive cells), Spike (D), CD68 (E) and CD3 (F). Scale bars: 100 microm (A); 50 microm (B-F). Inserts: high magnification of positive type I cells. Scale Bar: 15 microm.
case_images: fimmu-12-736529-g003.jpg
case_images: PMC8576382_01_fimmu-12-736529-g003.jpg
case_images: f3
case_images: Both right (Figure 3) and left (Supplementary Figure 3) CBs showed similar features, characterized by increased connective tissue in the absence of blood congestion or microthrombosis.
case_images: Right carotid body of Case 4 - Haematoxylin-eosin (A) and immunohistochemitries for nucleocapsid (B-C; arrows: positive cells), Spike (D; arrows: positive cells), CD68 (E) and CD3 (F). Scale bars: 100 microm (A); 50 microm (B-F). Inserts: high magnification of positive type I cells. Scale Bar: 15 microm.
case_images: fimmu-12-736529-g004.jpg
case_images: PMC8576382_01_fimmu-12-736529-g004.jpg
case_images: f4
case_images: Also in this case both CBs (right, Figure 4; left, Supplementary Figure 4) exhibited similar features.