case_images: PMC11769848_01
case_images: The pedigree of the Parkinson's disease with "antecedent essential tremor" kindred. (I) represents first generation; (II) represents second generation; (III) represents third generation; (IV) represents fourth generation. The square represents the male, the circle represents the female, and the diamond represents the gender protection, not revealing the gender; black for Parkinson's disease, grey for essential tremor; slash lines represent deceased family members; the arrows represent the proband.
case_images: NDT-21-79-g0002.jpg
case_images: PMC11769848_01_NDT-21-79-g0002.jpg
case_images: f0002
case_images: The pedigree of the family was obtained (Figure 2).
case_images: Intergroup differences in diffusion metrics of the cerebello-thalamo-motor cortical network and nigrostriatal-thalamo-motor cortical network. (a. and e.) statistics differences in fractional anisotropy of cerebello-thalamo-motor cortical network and nigrostriatal-thalamo-motor cortical network in ET vs NP, PD vs NP and ET vs PD. (b. and f). statistics differences in mean diffusivity of cerebello-thalamo-motor cortical network and nigrostriatal-thalamo-motor cortical network in ET vs NP, PD vs NP and ET vs PD. (c. and g). statistics differences in axial diffusivity of cerebello-thalamo-motor cortical network and nigrostriatal-thalamo-motor cortical network in ET vs NP, PD vs NP and ET vs PD. (d. and h). statistics differences in radial diffusivity of cerebello-thalamo-motor cortical network and nigrostriatal-thalamo-motor cortical network in ET vs NP, PD vs NP and ET vs PD. *P < 0.05.
case_images: NDT-21-79-g0003.jpg
case_images: PMC11769848_01_NDT-21-79-g0003.jpg
case_images: f0003
case_images: Compared PD family members with ET family members, no difference was detected in any other diffusion metrics (Figure 3). 
case_images: Intergroup differences in magnetic susceptibility in the SN, RN, and DN. (a). statistics differences in magnetic susceptibility of SN in ET vs NP, PD vs NP and ET vs PD. (b). statistics differences in magnetic susceptibility of RN in ET vs NP, PD vs NP and ET vs PD. (c). statistics differences in magnetic susceptibility of DN in ET vs NP, PD vs NP and ET vs PD. *P < 0.05; **P < 0.01; ***P < 0.001.
case_images: NDT-21-79-g0004.jpg
case_images: PMC11769848_01_NDT-21-79-g0004.jpg
case_images: f0004
case_images: The magnetic susceptibility was significantly different in the right RN (P = 0.016) between PD cases and ET cases (Figure 4).
case_images: Multimodal imaging performed in the three generations. First column: sMRI; second column: DTI-Tremor network; third column: DTI-PD network; fourth column: DTI-MIP; and fifth column: QSM. (a). the multimodal MRI findings of the proband (case II-4). (b). the multimodal MRI findings of the case III-2. (c). the multimodal MRI findings of the case IV-5.
case_images: NDT-21-79-g0005.jpg
case_images: PMC11769848_01_NDT-21-79-g0005.jpg
case_images: f0005
case_images: MRI are shown in Figures 5 and 6. Multivariate analysis showed that the increased magnetic susceptibility of L-RN was the best indicator for distinguishing ET from NP, the increased magnetic susceptibility of R-RN was the best indicator for distinguishing PD from NP, and significantly different in the R-RN between PD and ET.
case_images: Multimodal imaging performed in the three generations. First column: sMRI; second column: DTI-Tremor network; third column: DTI-PD network; fourth column: DTI-MIP; and fifth column: QSM. (a). the multimodal MRI findings of the case II-2. (b). the multimodal MRI findings of the case III-4. (c). the multimodal MRI findings of the case IV-6.
case_images: NDT-21-79-g0006.jpg
case_images: PMC11769848_01_NDT-21-79-g0006.jpg
case_images: f0006
case_images: MRI are shown in Figures 5 and 6. Multivariate analysis showed that the increased magnetic susceptibility of L-RN was the best indicator for distinguishing ET from NP, the increased magnetic susceptibility of R-RN was the best indicator for distinguishing PD from NP, and significantly different in the R-RN between PD and ET.