case_images: PMC11814467_01
case_images: Imaging changes during treatment. Magnetic resonance imaging (MRI) images demonstrating diagnosis, treatment responses. [(A-D) Sinonasal squamous cell carcinoma (SCC) was first diagnosed (15 July 2021); MRI scan showed a 3.7 cm x 2.0 cm soft tissue lesion in sinonasal and enlarged lymph node in the left upper neck region. (E-H) reduced tumor during four cycles of EP and durvalumab (October 15, 2021); MRI scan showed sinonasal SCC disappeared and neck lymph nodes reduced.].
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case_images: Contrast-enhanced magnetic resonance imaging (MRI) of the nasal cavity and sinuses and neck indicated an enhanced soft-tissue lesion in the left nasal and ethmoidal cellules measuring 3.7 cm x 2.0 cm at maximum cross-section and neck enlarged lymph nodes in the neck ( Figures 1A-D ).
case_images: Imaging changes during treatment. CT images demonstrating diagnosis, treatment responses. [(A-C) Small-cell lung cancer was first diagnosed (15 July 2021), CT scan showed a 3.7 cm x 2.1 cm pulmonary nodule metastases and enlarged mediastinal lymph nodes. (D-F) reduced tumor during four cycles of EP and durvalumab (15 October 2021), CT scan showed left lower lung tumor disappeared and mediastinal lymph nodes reduced.
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case_images: Figures 2A-C ). Fine-needle aspiration of the mass in the left nasal region and left lower lung showed high-grade NEC.
case_images: Photomicrographs of the sinonasal lesion (A-D) (magnification x40). (A) Hematoxylin and eosin (H&E) staining, (B) immunohistochemistry of synaptophysin, (C) chromogranin A, (D) neural cell adhesion molecule, CD56. Photomicrographs of the lung lesion (E-H) (magnification x40). (E) Hematoxylin and eosin (H&E) staining, (F) synaptophysin, (G) chromogranin A, (H) neural cell adhesion molecule, CD56.
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case_images: f3
case_images: Meanwhile, the tumor cells had a Ki-67 proliferation index of 95% and were negative for the squamous-cell marker p63 and adenocarcinoma marker cytokeratin-7 ( Figures 3A-H ).