case_images: PMC5987095_01
case_images: Hypothalamo-pituitary MRI showing a thickened pituitary stalk (7mm) with gadolinium enhancement and lost of the hyperintense signal on T1-weighed image
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case_images: PMC5987095_01_PAMJ-29-62-g001.jpg
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case_images: Hypothalamo-pituitary MRI showed a thickened pituitary stalk (7 mm) with gadolinium enhancement and lost of the hyperintense signal on T1-weighed image (Figure 1).
case_images: A technetium-99m-methyl-diphosphonate skeletal scintigraphy showing diffuse uptake in the diaphysis of long bones
case_images: PAMJ-29-62-g002.jpg
case_images: PMC5987095_01_PAMJ-29-62-g002.jpg
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case_images: We completed the work up with a technetium-99m-methyl-diphosphonate skeletal scintigraphy which showed diffuse uptake of the radiopharmaceutical, in the diaphysis of long bones (Figure 2).
case_images: A) inflammatory infiltrate with lymphocytes and spumous macrophages; B) positive CD68 foamy histiocytes
case_images: PAMJ-29-62-g003.jpg
case_images: PMC5987095_01_PAMJ-29-62-g003.jpg
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case_images: Computed tomography scan-guided femoral bone biopsies showed an inflammatory infiltrate with lymphocytes and spumous macrophages (Figure 3). Immunohistochemically, foamy histiocytes were positive for CD68 and negative for the S-100 protein, CD1a (Figure 3).