case_images: PMC11831891_01
case_images: Serial packed cell volume (PCV in %) in five dogs experiencing Heinz body anemia associated with propofol infusion for mechanical ventilation. The blue shaded region is the reference interval for PCV (37-55%). Where multiple PCVs were recorded in a day, the highest value for the day was used. If a PCV was not recorded on a given day, the Hct was used. The vertical lines denote the day on which the propofol CRI was discontinued for each case.
case_images: fvets-12-1500464-g001.jpg
case_images: PMC11831891_01_fvets-12-1500464-g001.jpg
case_images: fig1
case_images: TS as shown in Figures 1, 2). The recovery of anemia was spontaneous, and this dog did not require blood transfusion.
case_images: Serial total solids (g/L) in five dogs experiencing Heinz body anemia associated with propofol infusion for mechanical ventilation. The blue shaded region is the reference interval for TS (55-78 g/L). Where multiple TS were recorded in a day, the highest value for the day was used. The vertical lines denote the day on which the propofol CRI was discontinued for each case.
case_images: fvets-12-1500464-g002.jpg
case_images: PMC11831891_01_fvets-12-1500464-g002.jpg
case_images: fig2
case_images: TS as shown in Figures 1, 2). The recovery of anemia was spontaneous, and this dog did not require blood transfusion.
case_images: Cumulative propofol dose (mg/kg) in five dogs experiencing Heinz body anemia associated with propofol infusion for mechanical ventilation.
case_images: fvets-12-1500464-g003.jpg
case_images: PMC11831891_01_fvets-12-1500464-g003.jpg
case_images: fig3
case_images: MV (Day 7, cumulative dose 762 mg/kg, Figure 3), before decreasing to 17% on Day 12 (Figure 4).
case_images: Serial percentages of erythrocytes containing Heinz bodies in five dogs associated with propofol infusion during mechanical ventilation. The vertical lines denote the day on which the propofol CRI was discontinued for each case.
case_images: fvets-12-1500464-g004.jpg
case_images: PMC11831891_05_fvets-12-1500464-g004.jpg
case_images: fig4
case_images: PCV decreased from 49% (TS 50 g/L) on Day 1 to 42% on Day 2 (TS 60 g/L), at which time after 47 h of MV (cumulative propofol dose 516 mg/kg) a pathologist report documented 54% HBs (Figure 4) and numerous eccentrocytes.
case_images: Serial methemoglobin fraction (%) in five dogs experiencing Heinz body anemia associated with propofol infusion during mechanical ventilation. The blue shaded region is the reference interval for methemoglobin fraction as published for 41 healthy dogs.
case_images: fvets-12-1500464-g005.jpg
case_images: PMC11831891_05_fvets-12-1500464-g005.jpg
case_images: fig5
case_images: MetHb fraction ranged from 1.2 to 2.1% over the course of hospitalization (Figure 5).
case_images: PMC11831891_02
case_images: Serial percentages of erythrocytes containing Heinz bodies in five dogs associated with propofol infusion during mechanical ventilation. The vertical lines denote the day on which the propofol CRI was discontinued for each case.
case_images: fvets-12-1500464-g004.jpg
case_images: PMC11831891_05_fvets-12-1500464-g004.jpg
case_images: fig4
case_images: PCV decreased from 49% (TS 50 g/L) on Day 1 to 42% on Day 2 (TS 60 g/L), at which time after 47 h of MV (cumulative propofol dose 516 mg/kg) a pathologist report documented 54% HBs (Figure 4) and numerous eccentrocytes.
case_images: Serial methemoglobin fraction (%) in five dogs experiencing Heinz body anemia associated with propofol infusion during mechanical ventilation. The blue shaded region is the reference interval for methemoglobin fraction as published for 41 healthy dogs.
case_images: fvets-12-1500464-g005.jpg
case_images: PMC11831891_05_fvets-12-1500464-g005.jpg
case_images: fig5
case_images: MetHb fraction ranged from 1.2 to 2.1% over the course of hospitalization (Figure 5).
case_images: Wright stained blood smear demonstrating eccentrocytes and Heinz bodies (HBs) in a dog (Case 2) associated with propofol infusion. Magnification 1,000x. Asterisks show HBs projecting off eccentrocytes.
case_images: fvets-12-1500464-g006.jpg
case_images: PMC11831891_02_fvets-12-1500464-g006.jpg
case_images: fig6
case_images: Day 1 (TS 80 g/L) to 28% on Day 5 (TS 70 g/L, icterus), and further to 16% (TS 45 g/L) on Day 6, when hematology revealed a hematocrit of 13, 53% HBs, and marked eccentrocytosis (Figures 4, 6, 7). Due to concern for drug-induced oxidative cell injury, the propofol CRI was discontinued (cumulative dose 1,165 mg/kg) and replaced with alfaxalone20 (1-3 mg/kg/h IV CRI).
case_images: Rhodanile blue stained blood smear demonstrating eccentrocytes and Heinz bodies (HBs) in a dog (Case 2) associated with propofol infusion. Magnification 1,000x.
case_images: fvets-12-1500464-g007.jpg
case_images: PMC11831891_02_fvets-12-1500464-g007.jpg
case_images: fig7
case_images: Day 1 (TS 80 g/L) to 28% on Day 5 (TS 70 g/L, icterus), and further to 16% (TS 45 g/L) on Day 6, when hematology revealed a hematocrit of 13, 53% HBs, and marked eccentrocytosis (Figures 4, 6, 7). Due to concern for drug-induced oxidative cell injury, the propofol CRI was discontinued (cumulative dose 1,165 mg/kg) and replaced with alfaxalone20 (1-3 mg/kg/h IV CRI).
case_images: PMC11831891_03
case_images: Serial percentages of erythrocytes containing Heinz bodies in five dogs associated with propofol infusion during mechanical ventilation. The vertical lines denote the day on which the propofol CRI was discontinued for each case.
case_images: fvets-12-1500464-g004.jpg
case_images: PMC11831891_05_fvets-12-1500464-g004.jpg
case_images: fig4
case_images: PCV decreased from 49% (TS 50 g/L) on Day 1 to 42% on Day 2 (TS 60 g/L), at which time after 47 h of MV (cumulative propofol dose 516 mg/kg) a pathologist report documented 54% HBs (Figure 4) and numerous eccentrocytes.
case_images: Serial methemoglobin fraction (%) in five dogs experiencing Heinz body anemia associated with propofol infusion during mechanical ventilation. The blue shaded region is the reference interval for methemoglobin fraction as published for 41 healthy dogs.
case_images: fvets-12-1500464-g005.jpg
case_images: PMC11831891_05_fvets-12-1500464-g005.jpg
case_images: fig5
case_images: MetHb fraction ranged from 1.2 to 2.1% over the course of hospitalization (Figure 5).
case_images: PMC11831891_04
case_images: Serial percentages of erythrocytes containing Heinz bodies in five dogs associated with propofol infusion during mechanical ventilation. The vertical lines denote the day on which the propofol CRI was discontinued for each case.
case_images: fvets-12-1500464-g004.jpg
case_images: PMC11831891_05_fvets-12-1500464-g004.jpg
case_images: fig4
case_images: PCV decreased from 49% (TS 50 g/L) on Day 1 to 42% on Day 2 (TS 60 g/L), at which time after 47 h of MV (cumulative propofol dose 516 mg/kg) a pathologist report documented 54% HBs (Figure 4) and numerous eccentrocytes.
case_images: Serial methemoglobin fraction (%) in five dogs experiencing Heinz body anemia associated with propofol infusion during mechanical ventilation. The blue shaded region is the reference interval for methemoglobin fraction as published for 41 healthy dogs.
case_images: fvets-12-1500464-g005.jpg
case_images: PMC11831891_05_fvets-12-1500464-g005.jpg
case_images: fig5
case_images: MetHb fraction ranged from 1.2 to 2.1% over the course of hospitalization (Figure 5).
case_images: PMC11831891_05
case_images: Serial percentages of erythrocytes containing Heinz bodies in five dogs associated with propofol infusion during mechanical ventilation. The vertical lines denote the day on which the propofol CRI was discontinued for each case.
case_images: fvets-12-1500464-g004.jpg
case_images: PMC11831891_05_fvets-12-1500464-g004.jpg
case_images: fig4
case_images: PCV decreased from 49% (TS 50 g/L) on Day 1 to 42% on Day 2 (TS 60 g/L), at which time after 47 h of MV (cumulative propofol dose 516 mg/kg) a pathologist report documented 54% HBs (Figure 4) and numerous eccentrocytes.
case_images: Serial methemoglobin fraction (%) in five dogs experiencing Heinz body anemia associated with propofol infusion during mechanical ventilation. The blue shaded region is the reference interval for methemoglobin fraction as published for 41 healthy dogs.
case_images: fvets-12-1500464-g005.jpg
case_images: PMC11831891_05_fvets-12-1500464-g005.jpg
case_images: fig5
case_images: MetHb fraction ranged from 1.2 to 2.1% over the course of hospitalization (Figure 5).