case_images: PMC5315209_01
case_images: PMC5315209_02
case_images: Family tree of the AD patient with R62C mutation.. Notes: Family members refused the genetic tests and declined to provide detailed information on their age. However, none of them presented any type of dementia symptoms.. Abbreviation: AD, Alzheimer's disease.
case_images: cia-12-367Fig1.jpg
case_images: PMC5315209_02_cia-12-367Fig1.jpg
case_images: f1-cia-12-367
case_images: However, his 14-year-old daughter was mentally handicapped (Figure 1).
case_images: Imaging data of the patient with PSEN2 R62C.. Notes: (A) MRI data: mild cortical atrophy was present, but without lesions. (B) SPECT data: hypoperfusion was observed in frontal, limbic, and temporal brain areas.. Abbreviations: MRI, magnetic resonance imaging; SPECT, single-photon emission computed tomography.
case_images: cia-12-367Fig2.jpg
case_images: PMC5315209_02_cia-12-367Fig2.jpg
case_images: f2-cia-12-367
case_images: Brain MRI revealed mild cortical atrophy without any ischemic change or other lesions (Figure 2A). Brain SPECT showed moderate hypoperfusion in the frontal, limbic, and temporal areas (Figure 2B).
case_images: Clock drawing test.. Note: The contour and time setting are incorrect in the task of clock drawing.
case_images: cia-12-367Fig3.jpg
case_images: PMC5315209_02_cia-12-367Fig3.jpg
case_images: f3-cia-12-367
case_images: The delayed word recall score was 1 out of 3, and he scored 1 out of 3 in the task of clock drawing (Figure 3).