case_images: PMC4784190_01
case_images: Schematic Thromboelastogram  Platelet Mapping  tracings
case_images: JOACP-32-112-g001.jpg
case_images: PMC4784190_01_JOACP-32-112-g001.jpg
case_images: F1
case_images: TEG  PM  assay quantitatively measures blood viscoelastic properties during clot formation. The maximum amplitude (MA) in the thromboelastographic trace is dependent on platelet function [Figure 1].
case_images: Thromboelastogram  Platelet Mapping  analysis results for arachidonic acid (AA) added to measure MA due to thromboxane A2 pathway activation of non-inhibited platelets, yielding MAAA. Note that percent inhibition is 100
case_images: JOACP-32-112-g002.jpg
case_images: PMC4784190_01_JOACP-32-112-g002.jpg
case_images: F2
case_images: Figure 2. Figure 3 is the TEG  showing maximally stimulated platelets for the whole blood sample. The green lines represent fibrin mesh with no activated platelets. The red lines demonstrate fibrin mesh with platelets stimulated only by thromboxane A2 [Figure 2] and ADP [Figure 3] respectively. In Figure 2, the complete overlap of the red and green lines graphically indicates all platelets are inactivated by ASA. Note that the percent inhibition of platelets by both ASA [Figure 2 with 100% inhibition] and clopidogrel [Figure 3 with 95.2% inhibition] is near complete.
case_images: Thromboelastogram  Platelet Mapping  analysis results for adenosine diphosphate (ADP) added to measure MA due to ADP receptor uninhibited platelets, yielding MAADP. Note that percent inhibition is 95.2
case_images: JOACP-32-112-g003.jpg
case_images: PMC4784190_01_JOACP-32-112-g003.jpg
case_images: F3
case_images: TEG  showing maximally stimulated platelets for the whole blood sample. The green lines represent fibrin mesh with no activated platelets. The red lines demonstrate fibrin mesh with platelets stimulated only by thromboxane A2 [Figure 2] and ADP [Figure 3] respectively. The red line in Figure 3 indicates a small fraction of platelets can be activated by ADP while the majority remains inhibited. Note that the percent inhibition of platelets by both ASA [Figure 2 with 100% inhibition] and clopidogrel [Figure 3 with 95.2% inhibition] is near complete.