case_images: PMC7762671_01
case_images: (a) Cytology shows hypercellular material containing atypical cells, irregular borders, and hyperchromasia, 10x. (b) Close view, 40x of the atypical cells with hyperchromasia and overlapping and clear nuclei.
case_images: CRIPA2020-8037646.001.jpg
case_images: PMC7762671_01_CRIPA2020-8037646.001.jpg
case_images: fig1
case_images: The initial cytological analysis was obtained via fine-needle aspiration at our department, performed percutaneously using a small needle (25 gauge) and localized by ultrasound which resulted in the identification of a mesenchymal tumor with neoplastic cells with oval to spindle-shaped nuclei with moderate to high pleomorphism, irregular contours, and moderately eosinophilic cytoplasm (Figure 1).
case_images: (a) Hematoxylin-eosine from the biopsy material shows solid nests of spindle cells containing fascicular growth pattern, tumor cell merge with blood vessel walls, palisading of spindle cells with eosinophilic fibrillary cytoplasm, focal granularity, and large nuclei cigar-shaped blunt-ended with variable atypia. (b) High mitotic activity is seen with Ki67. (c-f) Tumor cells were positive for smooth muscle actin, caldesmon, and vimentin indicating a nonbreast tissue origin rather than indicating a smooth muscle origin. (d) Tumor cells were negative for CKMNF116.
case_images: CRIPA2020-8037646.002.jpg
case_images: PMC7762671_01_CRIPA2020-8037646.002.jpg
case_images: fig2
case_images: Tumor cells were positive for smooth muscle actin, caldesmon, calponin, and desmin which indeed indicate that the tumor is of smooth muscle origin (Figure 2).