case_images: PMC3517831_01
case_images: FLAIR AXIAL MRI images (TR 4140, TE 117) of the initial admission demonstrating multiple small bilateral cortical hyperintensities especially involving the occipital lobes (arrows). There was no evidence of mass effect or contrast enhancement on postcontrast images (not shown).
case_images: CRIM.ONCMED2012-819546.001.jpg
case_images: PMC3517831_01_CRIM.ONCMED2012-819546.001.jpg
case_images: fig1
case_images: Magnetic resonance imaging (MRI) of the brain demonstrated multiple small bilateral cortical hyperintensities, especially involving the occipital lobes and cerebellar hemispheres consistent with leukoencephalopathy (the patient had a normal MRI of the brain as a part of the staging workup prior to chemotherapy initiation) (Figure 1).
case_images: FLAIR AXIAL MRI images (TR 9000, TE 112) from the second admission demonstrating significant interval worsening of bilateral cortical hyperintensities throughout both cerebral hemispheres. Note the mild patient motion artifact.
case_images: CRIM.ONCMED2012-819546.002.jpg
case_images: PMC3517831_01_CRIM.ONCMED2012-819546.002.jpg
case_images: fig2
case_images: During his hospitalization, a repeat MRI showed significant interval worsening of bilateral cortical hyperintensities, ranging up to two centimeters, throughout both cerebral hemispheres (Figure 2).