case_images: PMC11380124_01
case_images: A photograph of the patient highlighting an enlarged left breast.
case_images: 10.1177_2632010X241276947-fig1.jpg
case_images: PMC11380124_01_10.1177_2632010X241276947-fig1.jpg
case_images: fig1-2632010X241276947
case_images: On examination, a palpable, painless left breast mass measuring 6 x 7 cm (Figure 1) with ipsilateral axillary lymphadenopathy was noted.
case_images: A plain chest X-ray showing normal lung fields and cardiac shadow with a soft tissue dense mass over the left chest.
case_images: 10.1177_2632010X241276947-fig2.jpg
case_images: PMC11380124_01_10.1177_2632010X241276947-fig2.jpg
case_images: fig2-2632010X241276947
case_images: The chest X-ray showed normal lung fields and a cardiac shadow with a soft tissue dense mass over the left chest (Figure 2).
case_images: Histopathology of the tumor displaying aggressive high-grade lymphoma characterized by a dense malignant lymphoid infiltrates fibro-adipose tissue and skeletal muscle with only scanty preserved breast tissue (H&E stained 40x original magnification) (A); a high power magnification of the tumor displaying population of diffuse large lymphocytic cells, moderately pleomorphic with scant dense cytoplasm and have enlarged hyperchromatic nuclei, with irregular contours, coarse chromatin and prominent nucleoli (H&E stained x200 original magnification) (B); immunohistochemical stains with CD20 highlighting strong membrane positivity confirming the diffuse large B-cell lymphoma (IHC 400x original magnification (C).
case_images: 10.1177_2632010X241276947-fig3.jpg
case_images: PMC11380124_01_10.1177_2632010X241276947-fig3.jpg
case_images: fig3-2632010X241276947
case_images: Histopathology evaluation of the incisional biopsy from the breast mass demonstrated diffuse proliferation of atypical lymphoid cells (Figure 3A and B). The tumor cells were strongly positive for CD20 (Figure 3C), BCL2, CD45, PAX5, and Ki67.