case_images: PMC10635677_01
case_images: This timeline presents a chronological overview of the main events in our patient's medical history from the diagnosis of metastatic renal cell carcinoma.
case_images: cro-2023-0016-0001-534595_F01.jpg
case_images: PMC10635677_01_cro-2023-0016-0001-534595_F01.jpg
case_images: F1
case_images: We report the case of a 68-year-old white female patient who was diagnosed with metastatic RCC in 2021 (shown in Fig. 1) as an incidental finding since a CT scan was performed during post-COVID surveillance due to unexplained coughing and increased inflammatory blood parameters.
case_images: History chart of ePROs as reported by the patient on her mobile device during axitinib and pembrolizumab treatment. Blue, well-being; yellow, hand-foot syndrome; red, stomach cramps/pain. ePROs, electronic patient-reported outcomes.
case_images: cro-2023-0016-0001-534595_F02.jpg
case_images: PMC10635677_01_cro-2023-0016-0001-534595_F02.jpg
case_images: F2
case_images: Furthermore, the patient was motivated to report side effects and her well-being by using the medidux  application, wherein she indicated a moderate (grade 1-2) hand-foot syndrome and some bowel irritation, known frequent side effects during axitinib therapy (shown in Fig. 2). Further extensive anamnestic workup then revealed that the patient took in a mixture of ten herbal medications twice daily (shown in Table 2), 4 h before and after the intake of axitinib, respectively, in order to relieve her gastrointestinal pain and other side effects of the systemic treatment such as her hand-foot syndrome (shown in Fig. 2).