case_images: PMC3426187_01
case_images: Section of intestine showing diffuse infiltration of mucosa and submucosa by neoplastic monotonous medium-sized cells. Individual cells have pale nuclei and occasional prominent nucleoli (Inset) ( H&E x 100X, Inset: H&E x 400X).
case_images: CRIM.GM2012-425358.001.jpg
case_images: PMC3426187_01_CRIM.GM2012-425358.001.jpg
case_images: fig1
case_images: Histology from the thickened ileum showed similar neoplastic monotonous cells of suspected lymphoid morphology as observed in the stomach (Figure 1).
case_images: Section of intestine showing neoplastic cells strongly positive for CD34 (immunohistochemistry x 400X).
case_images: CRIM.GM2012-425358.002.jpg
case_images: PMC3426187_01_CRIM.GM2012-425358.002.jpg
case_images: fig2
case_images: Immunohistochemistry performed on both stomach and ileum showed diffuse and strong positivity for CD34, MPO Ckit, MiB1 being 70% and negativity for CD3, CD20, and CD10 (Figures 2 and 3), thus making a diagnosis of extramedullary myeloid tumour or involvement by AML.
case_images: Section of intestine showing neoplastic cells strongly positive for MPO (immunohistochemistry x 400X).
case_images: CRIM.GM2012-425358.003.jpg
case_images: PMC3426187_01_CRIM.GM2012-425358.003.jpg
case_images: fig3
case_images: Immunohistochemistry performed on both stomach and ileum showed diffuse and strong positivity for CD34, MPO Ckit, MiB1 being 70% and negativity for CD3, CD20, and CD10 (Figures 2 and 3), thus making a diagnosis of extramedullary myeloid tumour or involvement by AML.
case_images: Bone marrow aspirate showing hypercellular marrow with 90% blasts morphology cells (Wrights x 1000X).
case_images: CRIM.GM2012-425358.004.jpg
case_images: PMC3426187_01_CRIM.GM2012-425358.004.jpg
case_images: fig4
case_images: Subsequently, a bone marrow aspirate and biopsy done showed a hypercellular marrow containing almost 85%-90% cells of blast morphology, thus confirming marrow involvement by acute leukemia (Figure 4).