case_images: PMC10482433_01
case_images: The typical image of the CT scan and gastroscopy examination. (A) The typical CT scan images; (B) the image of the gastroscopy; (C-I) the H&E staining and IHC staining of the neoplasm tissue of the patient. Scale bar = 100 mum.
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case_images: PMC10482433_01_fonc-13-1211668-g001.jpg
case_images: f1
case_images: Figure 1A ). Further gastroscopy revealed an ulcerative neoplasm in the stomach body and the pathology examination demonstrated that it was adenocarcinoma ( Figure 1B ). Subsequently, the following therapy-related targets were detected: MLH1, MSH2, MSH6, and PMS2 were positive; CPS of PD-L1 (clone number 22C3) staining was 1; and HER2 staining was negative ( Figures 1C-I ).
case_images: The treatment scheme of the combined therapy of ASKB589 and CAPOX chemotherapy.
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case_images: PMC10482433_01_fonc-13-1211668-g002.jpg
case_images: f2
case_images: He received six courses of ASKB589 and chemotherapy in total from July 2022 to November 2022 ( Figure 2 ).
case_images: The clinical characteristics during treatment. (A) The enhanced CT images of the patient during treatment. The treatment began on 14 July 2022 and stopped on 29 November 2022. (B) The level of CEA during the treatment. The treatment began in week 0 and stopped in week 20. (C) The level of albumin during the treatment. The treatment began in week 0 and stopped in week 20. The arrow refers to the time point of the ASKB589 infusion. (D) The level of CA125 during the treatment. The treatment began in week 0 and stopped in week 20.
case_images: fonc-13-1211668-g003.jpg
case_images: PMC10482433_01_fonc-13-1211668-g003.jpg
case_images: f3
case_images: CT scan revealed a satisfactory response (PR, almost cCR) with the liver masses almost disappearing and CEA decreased to the normal level ( Figures 3A, B ). However, he developed peritoneal effusion and hypoalbuminemia after 5 weeks of the treatment ( Figures 3A, C ). As treatment continued, the patient developed a much larger volume of ascites and CA125 grew significantly, while there was no significant change in albumin and urine protein ( Figure 3 ).