case_images: PMC11260612_01
case_images: 18F-FDG PET/CT scan of the patient. A solid nodule in the left upper lobe with increased 18F-FDG uptake was detected.
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case_images: f1
case_images: The standardized uptake value of the nodule is approximately 6.7 ( Figure 1 ), indicative of a malignancy.
case_images: Chest CT of the patient. Plain CT on November 18, 2021 (A-D) and contrast enhanced CT on November 28 (E-H). Patches of ground glass opacity can be observed around the lesion on image (G, H).
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case_images: PMC11260612_01_fonc-14-1393203-g002.jpg
case_images: f2
case_images: Chest CT of the patient on November 18, 2021 showed a left upper lung nodule measuring approximately 18x13mm ( Figures 2A-D ), the nodule has an irregular shape with a lobulated appearance. A contrast-enhanced CT 10 days later detected an obvious increase in the size of the nodule, measuring about 23x20mm, with clear boundaries and moderate uniform enhancement, and multiple patchy ground-glass opacity around the lesion ( Figures 2E-H ).
case_images: Timeline of the patient's diagnosis and treatment.
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case_images: PMC11260612_01_fonc-14-1393203-g003.jpg
case_images: f3
case_images: Histopathology and immunohistochemistry of the patient. (A, D), H&E stain. (B, E), Syn. (C, F), CK-19. Original magnification: x40 and x 200.
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case_images: f4
case_images: TTF-1 (minority +), CD56 (-), CgA (-), Syn (-), CD68 (-), LCA (-). PDL1 (about 60% positive), Ki-67 (about 60% positive) ( Figure 4 ). The final pathology diagnosis was sarcomatoid carcinoma with extensive necrosis (giant cell carcinoma with necrosis), and the tumor's pathological stage is classified as T1N0M0, genetic testing results revealed a MET gene mutation in the patient.