case_images: PMC10646431_01
case_images: Body mass ultrasound of the patient.
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case_images: When the mass was imaged using ultrasound, a 2.2 cm x1.9 cm x1.1 cm very hypoechoic nodule with a regular shape, distinct borders, and uneven internal echogenicity was detected in the fatty layer of the right temporal region (Figure 1).
case_images: Orbital MRI showing a tumor in the right temporal area.
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case_images: An orbital MRI, performed in February 2022, showed an oval T1 and T2 compression lipid high-signal shadow with clear borders in the right temporal subcutis that was approximately 15 mm x 27 mm (Figure 2).
case_images: PMC10646431_02
case_images: Hematoxylin and eosin staining of the tumor tissue (H&E, x5). Neoplastic cells are small to moderately sized, with little cellular heterogeneity, and some infiltration of small lymphocytes and histiocytes can be observed in the background.
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case_images: Infiltrating cells comprised mainly follicular centrocytes and centroblasts, along with several histiocytes (Figure 3).
case_images: (A) Immunohistochemistry showing neoplastic cells diffusely positive for CD20 (x10). (B) Follicular dendritic cell networks strongly expressing CD21 (x10). (C) BCL-2 is variably expressed at different sites, and in this figure BCL-2 is negative (x10).
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case_images: f4
case_images: The immunohistochemical staining showed a strong diffuse CD20 positivity for germinal center B-cells with PAX5 and PD1 positivity (Figure 4A). The follicular dendritic cell network was compressed with CD21-positive cells (Figure 4B). There was variability in Bcl-2 expression in the follicle center and interstitial areas (Figure 4C).
case_images: PMC10646431_03