case_images: PMC5429914_01
case_images: (a, b, c, d) Erythematous papules, plaques, hemorrhagic ulcerations, and atrophic scars in different sizes scattered all over the body.
case_images: CRIDM2017-3194738.001.jpg
case_images: PMC5429914_01_CRIDM2017-3194738.001.jpg
case_images: fig1
case_images: A 18-year-old female presented to the outpatient clinic of dermatology with a 15-year history of waxing and waning course of erythematous papules, plaques, hemorrhagic ulcerations, and atrophic scars (Figures 1(a), 1(b), 1(c), and 1(d)).
case_images: (a, b) Regular acanthotic epidermis, a dense dermal infiltrate of pleomorphic atypical lymphoid cells, and destruction of the blood vessels' walls by abnormal lymphocytes. (c) The cells were strongly positive for CD30.
case_images: CRIDM2017-3194738.002.jpg
case_images: PMC5429914_01_CRIDM2017-3194738.002.jpg
case_images: fig2
case_images: The skin biopsy revealed regular acanthotic epidermis, a dense dermal infiltrate of pleomorphic atypical lymphoid cells, and destruction of the blood vessels' walls by abnormal lymphocytes (Figures 2(a) and 2(b)). Biopsy revealed abnormal lymphocytes which were predominantly positive for CD30 (Figure 2(c)) and mostly CD8+ lymphoid cells, especially angiocentric infiltrates.
case_images: (a, b, c) All previous persistent lesions were healed completely and no new lesions were observed after two-month treatment with IFN alfa-2a.
case_images: CRIDM2017-3194738.003.jpg
case_images: PMC5429914_01_CRIDM2017-3194738.003.jpg
case_images: fig3
case_images: After two-month treatment with IFN alfa-2a, she was finally feeling well and there were no new lesions and all previous persistent lesions were healed completely (Figures 3(a), 3(b), and 3(c)).