case_images: PMC5337370_01
case_images: Low power H&E slide. The lobular architecture with cribriform pattern can be identified. There is no connection to the epidermis.
case_images: CRIPA2017-6343709.001.jpg
case_images: PMC5337370_01_CRIPA2017-6343709.001.jpg
case_images: fig1
case_images: It displayed a lobular architecture with solid and cribriforming areas (Figure 1).
case_images: High power H&E slide. The nuclei are round to oval with conspicuous nucleoli and a finely stippled chromatin pattern.
case_images: CRIPA2017-6343709.002.jpg
case_images: PMC5337370_01_CRIPA2017-6343709.002.jpg
case_images: fig2
case_images: The nuclei were medium-sized, monomorphic, and round to oval with 1 to 2 conspicuous nucleoli, the chromatin was finely stippled and resembled the "salt and pepper" pattern seen in neuroendocrine tumors, and there was a moderate amount of eosinophilic cytoplasm (Figure 2).
case_images: High power H&E slide. Both intracytoplasmic and extracellular mucin are present.
case_images: CRIPA2017-6343709.003.jpg
case_images: PMC5337370_01_CRIPA2017-6343709.003.jpg
case_images: fig3
case_images: Intracytoplasmic mucin could be identified, as it displayed a light blue hue on H&E stained slides, and extracellular mucin was also present throughout the tumor (Figure 3).
case_images: Positive synaptophysin staining.
case_images: CRIPA2017-6343709.004.jpg
case_images: PMC5337370_01_CRIPA2017-6343709.004.jpg
case_images: fig4
case_images: There was strong immunohistochemical staining for synaptophysin (Figure 4), chromogranin, NSE, and CD57 and focal positive staining for CD56.
case_images: Positive estrogen receptor staining (90-100%).
case_images: CRIPA2017-6343709.005.jpg
case_images: PMC5337370_01_CRIPA2017-6343709.005.jpg
case_images: fig5
case_images: Estrogen and progesterone nuclear stains were positive in 90-100% of the tumor cells (Figure 5).
case_images: Smooth muscle myosin heavy chain (SMMHC) highlights the myoepithelial cells around the lobules.
case_images: CRIPA2017-6343709.006.jpg
case_images: PMC5337370_01_CRIPA2017-6343709.006.jpg
case_images: fig6
case_images: Smooth muscle myosin heavy chain (SMMHC) stained focal myoepithelial cells around the larger lobules (Figure 6).