case_images: PMC10800422_01
case_images: MRI before admission (A-J), axial T2-weighted image (A-E), and diffusion-weighted imaging (F-J) show a hyper intense signal in the left frontal lobe, temporal lobe, bilateral insula lobe, and hippocampus. MRI of after IVIG use (K-T), axial T2-weighted image (K-O), and diffusion-weighted imaging (P-T) show that the lesions scattered in the left frontal lobe, bilateral temporal lobe, bilateral insula lobe, and hippocampus were not significantly different from before. The white arrowhead showing lesions in MRI. MRI, magnetic resonance imaging.
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case_images: Brain magnetic resonance imaging (MRI) revealed multiple lesions scattered in the left frontal lobe, bilateral temporal lobe, bilateral insula lobe, and hippocampus showing hyperintensity on T2-weighted and diffusion weighted imaging (DWI) ( Figures 1A-J ). Repeated brain MRI showed no significant changes in lesions scattered in the left frontal lobe, bilateral temporal lobe, bilateral insula lobe, and hippocampus ( Figures 1K-T ).
case_images: (A) Negative controls without IgLON5 antibodies in the serum. (B) Positive controls from a patient with classical anti-IgLON5 encephalitis. (C) IgLON5-IgG test results (1:30) of the current patient. (D) The IgG 3 subtype with IgLON5 test results of the current patient. GFP, green fluorescent protein; Neg Con, negative control; Pos Con, positive control.
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case_images: CBA revealed that the anti-IgLON5 antibody tested positive (1:30) in serum and (1:1) in the CSF for antibodies against cell surface proteins, whereas all other antibodies were both negative ( Figure 2 ).
case_images: MRI of 2 months after discharge. Axial T2-weighted image (A-E), axial fluid attenuated inversion recovery sequence (F-J), and diffusion-weighted imaging (K-O) show the lesions in the left lobe, bilateral temporal lobe, bilateral insula lobe, and hippocampus were reduced, and no new-onset abnormal signal was found on DWI. The white arrowhead showing lesions in MRI. MRI, magnetic resonance imaging.
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case_images: PMC10800422_01_fimmu-14-1329540-g003.jpg
case_images: f3
case_images: Repeated MRI showed that the lesions in the left frontal lobe, bilateral temporal lobe, bilateral insula lobe, and hippocampus were reduced and no new-onset abnormal signal was found on DWI ( Figure 3 ).
case_images: Clinical course and treatment in the case.
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case_images: However, the patient was reluctant to undergo another test for CSF and serum-related autoimmune antibodies.  Figure 4  displays the chronological sequence of the patient's clinical symptoms and interventions, along with relevant data.