case_images: PMC10890903_01
case_images: Large flaky scales in the background of diffuse erythema on the face of a pemphigus foliaceus patient.
case_images: CRIDM2024-6748340.001.jpg
case_images: PMC10890903_01_CRIDM2024-6748340.001.jpg
case_images: fig1
case_images: On examination, the facial skin was covered with large flaky scales in the background of diffuse erythema, and its tightness caused mild ectropion (Figure 1). After 4 weeks, this treatment was effective in reducing desquamation, redness, and healing of the old erosions (Figures S1 and S2).
case_images: Diffuse scaly and crusted lesions on the trunk and extremities of a pemphigus foliaceus patient.
case_images: CRIDM2024-6748340.002.jpg
case_images: PMC10890903_01_CRIDM2024-6748340.002.jpg
case_images: fig2
case_images: Generalized scaling and crusted erythematous patches were interspersed with moist, eroded areas on the trunk and extremities (Figure 2). After 4 weeks, this treatment was effective in reducing desquamation, redness, and healing of the old erosions (Figures S1 and S2).
case_images: Skin biopsy of a pemphigus foliaceus patient with H&E staining shows a cleft within the subcorneal layer and superficial acantholysis. H&E, hematoxylin and eosin.
case_images: CRIDM2024-6748340.003.jpg
case_images: PMC10890903_01_CRIDM2024-6748340.003.jpg
case_images: fig3
case_images: Microscopic examination of the scaly erythematous lesions showed multiple focal splits at the level of the subcorneal layer, with some superficial acantholysis, which supported the diagnosis of PF (Figure 3). From the third month onward, all skin lesions healed (Figures S3 and S4), and no new blisters or erythema was observed.
case_images: Positive DIF findings demonstrate C3 and IgG deposition in the upper epidermis of a pemphigus foliaceus patient. DIF, direct immunofluorescence; Ig, immunoglobulin.
case_images: CRIDM2024-6748340.004.jpg
case_images: PMC10890903_01_CRIDM2024-6748340.004.jpg
case_images: fig4
case_images: In addition, direct immunofluorescence (DIF) of the perilesional skin yielded intercellular immunoglobulin (Ig) G and C3 deposits in the superficial epidermis (Figure 4). From the third month onward, all skin lesions healed (Figures S3 and S4), and no new blisters or erythema was observed.