case_images: PMC10799589_01
case_images: (Left upper) H&E stain (100x magnification) demonstrating invasive HG UC (malignant epithelial component). (Right upper) H&E (100x magnification) demonstrating spindled epithelioid cells with HG pleomorphic nuclei and atypical mitotic figures (resembling pleomorphic HG sarcoma) and consistent with UC. (Lower row) 40x magnification showing sarcomatoid UC with cytokeratin AE1/AE3 antibody (epithelium stain) demonstrating an epithelial to mesenchymal transition (right side).. AE1 and AE3, monoclonal antibodies; H&E, hematoxylin and eosin; HG, high grade; UC, urothelial carcinoma.
case_images: 10.1177_17562872241226582-fig1.jpg
case_images: PMC10799589_01_10.1177_17562872241226582-fig1.jpg
case_images: fig1-17562872241226582
case_images: TURBT revealed a final pathology of invasive HG UC with areas of spindle cell differentiation consistent with sarcomatous changes (Figure 1). There was no evidence of lymphovascular invasion and the muscularis propria was present but uninvolved, affirming pT1 disease.