case_images: PMC6167527_01
case_images: Clinical image of the cutaneous eruption that developed after six cycles of nivolumab. On the back, there were widespread and numerous 3-10 mm pink to pink-brown thin flat-topped papules and plaques with scale.
case_images: fonc-08-00405-g0001.jpg
case_images: PMC6167527_01_fonc-08-00405-g0001.jpg
case_images: F1
case_images: On examination, he was noted to have too numerous to count 3-10 mm pink to pink-brown thin papules and plaques, which were flat-topped with scale over the chest, abdomen, back (Figure 1), arms, legs, and penile shaft, some of which had an erythematous base.
case_images: Punch biopsy of a representative lesion (left upper arm). Hematoxylin and eosin staining revealed an acanthotic epidermis with hyperkeratosis and hypergranulosis. There is a band-like lymphohistiocytic infiltrate at the dermal-epidermal junction with focal squamatization of the basal cell layer and scattered necrotic keratinocytes (20 x magnification).
case_images: fonc-08-00405-g0002.jpg
case_images: PMC6167527_01_fonc-08-00405-g0002.jpg
case_images: F2
case_images: A punch biopsy of a characteristic lesion on the left upper arm was performed, which showed a slightly acanthotic epidermis with prominent hyperkeratosis and hypergranulosis, with a band-like lymphohistiocytic infiltrate, focal squamatization of the basal cell layer, and necrotic keratinocytes (Figure 2).
case_images: Clinical image after successful treatment with NBUVB. On the back, there were widespread and numerous hyperpigmented macules coalescing into patches. There was no erythema or scale.
case_images: fonc-08-00405-g0003.jpg
case_images: PMC6167527_01_fonc-08-00405-g0003.jpg
case_images: F3
case_images: On clinical examination 6 months later, complete resolution of the rash was observed with only residual post-inflammatory hyperpigmentation while still on 4 mg daily prednisone (Figure 3).