case_images: PMC10805407_01
case_images: Poliosis of eyebrows and eyelashes seen with Ipi/Nivo therapy.
case_images: cro-2024-0017-0001-535745_F01.jpg
case_images: PMC10805407_01_cro-2024-0017-0001-535745_F01.jpg
case_images: F1
case_images: External examination revealed poliosis of her eyebrows and eyelashes (Fig. 1).
case_images: Imaging at presentation, 7 months' follow-up, and 20 months' follow-up. a, b Fundus photos of OD and OS at presentation with BCVA of 20/20 and 20/25, respectively. Note the multiple hypopigmented lesions 1-3 DD in size OU with increased view of underlying choroidal vessels. c OD OCT at presentation that shows choroidal hyperreflectivity without retinal elevation. d Infrared image at presentation with green line indicating location of OD OCT. e OS OCT of macula at presentation. f Infrared image at presentation with green line indicating location of OS OCT. g, h Choroidal lesions at 7 months with increased blanching approximately 1-3 DD in size OU even 6 months after cessation of Ipi/Nivo. i-l Angiography at 7 months showing early window defects through choroidal lesions with normal perfusion and no evidence of vasculitis (l, k are OD and j, l are OS). m, n Stable choroidal lesions OU at 20 months without any changes in vision.
case_images: cro-2024-0017-0001-535745_F02.jpg
case_images: PMC10805407_01_cro-2024-0017-0001-535745_F02.jpg
case_images: F2
case_images: Fundus photography was notable for multiple 1-3 disc-diameter flat hypopigmented/amelanotic placoid areas exposing underlying choroidal vessels in both eyes (Fig. 2a, b). OCT through the lesions demonstrated choroidal hyporeflectivity without retinal elevation (Fig. 2c-f). There was no evidence of enlargement or development of new areas of involvement (Fig. 2g, h). Fluorescein angiography showed early window defects through the affected areas with normal perfusion and no evidence of vasculitis (Fig. 2i-l). The choroidal lesions were unchanged from her most recent visit but remained more blanched than her original exam (Fig. 2m, n).