case_images: PMC6304607_01
case_images: Nests and cribriform structures of variable size and shape, separated by moderate amount of fibrotic dense stroma (H&E; 50x).
case_images: CRIU2018-3614387.001.jpg
case_images: PMC6304607_01_CRIU2018-3614387.001.jpg
case_images: fig1
case_images: Microscopically, the neoplasm is composed of cohesive, uniform, cuboidal cells with minimal cytoplasm, arranged in nests and cribriform structures of variable size and shape, separated by moderate amount of fibrotic dense stroma (Figure 1).
case_images: Cohesive cuboidal cells with minimal amount of cytoplasm, round uniform nuclei with regular contour, finely granular chromatin, no nucleoli, and no mitotic activity (H&E; 200x).
case_images: CRIU2018-3614387.002.jpg
case_images: PMC6304607_01_CRIU2018-3614387.002.jpg
case_images: fig2
case_images: Mitotic figures are absent to extremely rare (2 per 10 HPF) (Figure 2).
case_images: Synaptophysin immunohistochemical stain (cytoplasmic staining) (200x).
case_images: CRIU2018-3614387.003.jpg
case_images: PMC6304607_01_CRIU2018-3614387.003.jpg
case_images: fig3
case_images: Tumor cells stained positive with cytokeratin (clones AE1/AE3), synaptophysin (Figure 3), chromogranin A (Figure 4), EMA, and CDX-2 (Figure 5) but negative for CD99, TTF-1, CK7, CK20, and CEA.
case_images: Chromogranin A immunohistochemical stain (cytoplasmic staining) (200x).
case_images: CRIU2018-3614387.004.jpg
case_images: PMC6304607_01_CRIU2018-3614387.004.jpg
case_images: fig4
case_images: Tumor cells stained positive with cytokeratin (clones AE1/AE3), synaptophysin (Figure 3), chromogranin A (Figure 4), EMA, and CDX-2 (Figure 5) but negative for CD99, TTF-1, CK7, CK20, and CEA.
case_images: CDX2 immunohistochemical stain (nuclear staining) (200x).
case_images: CRIU2018-3614387.005.jpg
case_images: PMC6304607_01_CRIU2018-3614387.005.jpg
case_images: fig5
case_images: Tumor cells stained positive with cytokeratin (clones AE1/AE3), synaptophysin (Figure 3), chromogranin A (Figure 4), EMA, and CDX-2 (Figure 5) but negative for CD99, TTF-1, CK7, CK20, and CEA.