case_images: PMC6280303_01
case_images: Haematoxylin and eosin stain at 400x magnification demonstrating numerous apoptotic bodies and patchy fibrotic changes in the perivenular and portal areas. This is consistent with generalized cholestatic and inflammatory changes.
case_images: CRIHEP2018-2816907.001.jpg
case_images: PMC6280303_01_CRIHEP2018-2816907.001.jpg
case_images: fig1
case_images: A core needle biopsy of the liver was performed, which revealed inflammatory activity and apoptotic bodies spanning all zones of the liver, in keeping with acute cholestatic hepatitis, a pathological picture often related to drug-induced liver injury or nonhepatic viral infection (Figures 1 and 2).
case_images: Periodic acid-Schiff stain at 100x magnification demonstrating decreased parenchymal glycogenation. PAS diastase reveals numerous Kupffer cells and portal macrophages.
case_images: CRIHEP2018-2816907.002.jpg
case_images: PMC6280303_01_CRIHEP2018-2816907.002.jpg
case_images: fig2
case_images: A core needle biopsy of the liver was performed, which revealed inflammatory activity and apoptotic bodies spanning all zones of the liver, in keeping with acute cholestatic hepatitis, a pathological picture often related to drug-induced liver injury or nonhepatic viral infection (Figures 1 and 2).