case_images: PMC10563476_01
case_images: (a) Imaging showing the initial axial fluid-attenuated inversion recovery magnetic resonance imaging (MRI) of the patient's brain, showing a hyper-intensive lesion in the posterior right frontal lobe. Typical for PML is sparing of the more superficial cortex. (b-d) Images obtained at days 12, 40, and 720 post-treatment initiation, showed significant resolution based on a decrease in the hyperintensity of the lesion.. PML, progressive multifocal leukoencephalopathy.
case_images: 10.1177_20406207231201721-fig1.jpg
case_images: PMC10563476_01_10.1177_20406207231201721-fig1.jpg
case_images: fig1-20406207231201721
case_images: A magnetic resonance imaging (MRI) of the brain was performed, showing a lesion in the posterior right frontal lobe with mass effect and patchy enhancement [Figure 1(a)]. An MRI performed on Day 12 showed evident resolution of previous radiographic abnormalities [Figure 1(b)-(d)].
case_images: Histopathology of brain biopsy. (a) H&E stain showing enlarged astrocytes with a large inclusion-bearing nucleus, (b) chromogenic in situ hybridization (CISH) for the JC virus.. H&E, hematoxylin and eosin.
case_images: 10.1177_20406207231201721-fig2.jpg
case_images: PMC10563476_01_10.1177_20406207231201721-fig2.jpg
case_images: fig2-20406207231201721
case_images: PML (Figure 2). Participation in the idiotype vaccine trial was discontinued.
case_images: Timeline of his diagnostic and treatment history.
case_images: 10.1177_20406207231201721-fig3.jpg
case_images: PMC10563476_01_10.1177_20406207231201721-fig3.jpg
case_images: fig3-20406207231201721
case_images: A timeline highlighting his disease and treatment history is illustrated in Figure 3.