case_images: PMC10755457_01
case_images: (A-D): Brain MRI of the patient at the onset. (A, B) FLAIR. (C) DWI. (D) arterial spin labeling (ASL). Bilateral medial temporal lobes and left insular gyrus were swollen with high signal (A-C). ASL images showed left dominant asymmetric hippocampus cerebral blood flow increase (D). (E) Pelvic CT of the patient before IVMP. Mild lymph node enlargement in the inguinal regions. The right inguinal lymph node was the largest (arrow). (F) Pelvic CT of the patient after IVMP. The lymph node had shrunk. The hyperdense dots on the skin are markers placed for biopsy. (G, H) Histological findings of hematoxylin-eosin staining in the abdominal periaortic lymph node. Enlarged atypical cells proliferated, and Hodgkin and Reed-Sternberg cells were observed. (I, J) Histological findings of Kluver-Barrera staining in the left hippocampus. Spongiosis and neuronal loss were observed.
case_images: fimmu-14-1188154-g001.jpg
case_images: PMC10755457_02_fimmu-14-1188154-g001.jpg
case_images: f1
case_images: Scattered atypical large cells, e.g., Hodgkin, mummified, lacunar, and Reed-Sternberg cells were observed in the fibrosing lymph nodes ( Figures 1G, H ). The cerebral tissues of the limbic system showed spongiosis, neuronal loss, gliosis, mild perivascular cuffing of lymphocytes, and petechial hemorrhages ( Figures 1I, J ).
case_images: PMC10755457_02
case_images: (A-D): Brain MRI of the patient at the onset. (A, B) FLAIR. (C) DWI. (D) arterial spin labeling (ASL). Bilateral medial temporal lobes and left insular gyrus were swollen with high signal (A-C). ASL images showed left dominant asymmetric hippocampus cerebral blood flow increase (D). (E) Pelvic CT of the patient before IVMP. Mild lymph node enlargement in the inguinal regions. The right inguinal lymph node was the largest (arrow). (F) Pelvic CT of the patient after IVMP. The lymph node had shrunk. The hyperdense dots on the skin are markers placed for biopsy. (G, H) Histological findings of hematoxylin-eosin staining in the abdominal periaortic lymph node. Enlarged atypical cells proliferated, and Hodgkin and Reed-Sternberg cells were observed. (I, J) Histological findings of Kluver-Barrera staining in the left hippocampus. Spongiosis and neuronal loss were observed.
case_images: fimmu-14-1188154-g001.jpg
case_images: PMC10755457_02_fimmu-14-1188154-g001.jpg
case_images: f1
case_images: Scattered atypical large cells, e.g., Hodgkin, mummified, lacunar, and Reed-Sternberg cells were observed in the fibrosing lymph nodes ( Figures 1G, H ). The cerebral tissues of the limbic system showed spongiosis, neuronal loss, gliosis, mild perivascular cuffing of lymphocytes, and petechial hemorrhages ( Figures 1I, J ).
case_images: Clinical course of the patient.
case_images: fimmu-14-1188154-g002.jpg
case_images: PMC10755457_02_fimmu-14-1188154-g002.jpg
case_images: f2
case_images: The clinical course of this case is shown in  Figure 2 .
case_images: PMC10755457_03
case_images: PMC10755457_04