case_images: PMC9702988_01
case_images: Light microscopy images of kidney tissue. (A) Globally sclerostic glomeruli. Silver x400. (B) Globally sclerotic glomeruli (arrow). Masson Trichrome x400. (C) Tubular atrophy (arrow) and renal interstitial fibrosis (star). Hematoxylin-eosin x200. (D) Proliferation of mesangial cells and segmental accumulation of matrix. Hematoxylin-eosin x400.
case_images: fped-10-1043502-g001.jpg
case_images: PMC9702988_01_fped-10-1043502-g001.jpg
case_images: F1
case_images: Representative findings were displayed in Figure 1.
case_images: Pedigree analysis of this family. We identified 2 brothers, the proband (III-4) and the affected brother (III-6) who were admitted to our hospital, with proteinuria. The proband was diagnosed with FSGS based on kidney biopsy. The closed boxes represent the patients with proteinuria in this family. The pedigree suggested an X-linked pattern of inheritance. Blood was collected from the proband and 5 additional family members indicated by asterisks.
case_images: fped-10-1043502-g002.jpg
case_images: PMC9702988_01_fped-10-1043502-g002.jpg
case_images: F2
case_images: The pedigree presented in Figure 2 was suggestive of an X-linked mode of inheritance.