case_images: PMC5763055_01
case_images: Histologic examination of surgically resected pulmonary carcinoid tumor shows finely granular nuclear chromatin, eosinophilic cytoplasm, and rosette formation (a) and positive expression of chromogranin A (b).
case_images: CRIONM2017-1564819.001.jpg
case_images: PMC5763055_01_CRIONM2017-1564819.001.jpg
case_images: fig1
case_images: Histopathologic examination of the surgical specimen revealed finely granular nuclear chromatin, eosinophilic cytoplasm, and rosette formation (Figure 1). The immunohistology was positive for synaptophysin, chromogranin A, and CD56 (Figure 1).
case_images: Histologic examination of a liver biopsy specimen shows a well-differentiated tumor (a) with positive expression of chromogranin A (b).
case_images: CRIONM2017-1564819.002.jpg
case_images: PMC5763055_01_CRIONM2017-1564819.002.jpg
case_images: fig2
case_images: Percutaneous liver biopsy of one of the lesions demonstrated well-differentiated tumor with positive expressions of chromogranin A, synaptophysin, and CD56 (Figure 2).
case_images: Abdominal contrast-enhanced CT shows multiple low-density areas, hepatomegaly, and metastasis to the spleen.
case_images: CRIONM2017-1564819.003.jpg
case_images: PMC5763055_01_CRIONM2017-1564819.003.jpg
case_images: fig3
case_images: Abdominal contrast-enhanced CT revealed multiple tumors in the liver and spleen, as well as hepatomegaly (Figure 3).
case_images: Immunohistochemical analysis demonstrates immunoreactivity for somatostatin receptor 2 antibody immunostaining in most tumor cells in the lung (a) and liver (b).
case_images: CRIONM2017-1564819.004.jpg
case_images: PMC5763055_01_CRIONM2017-1564819.004.jpg
case_images: fig4
case_images: Considering that immunostaining for somatostatin receptor 2 antibody was scored as 3 (circumferential membranous reactivity in >50% of tumor cells), subcutaneous octreotide therapy was started at a dose of 100 mug/day (Figure 4).