case_images: PMC7662390_01
case_images: The pump (Lenus Pro , 20 ml) implanted in the left hypochondria for intravenous treprostinil delivery (patient 1).
case_images: fmed-07-539707-g0001.jpg
case_images: PMC7662390_01_fmed-07-539707-g0001.jpg
case_images: F1
case_images: The patient being reluctant to IV access with external pump an implantable pump was proposed (LenusPro  20 ml, Figure 1).
case_images: Treprostinil delivery flow rate by the LenusPro  pump for patient 1 (black) and patient 2 (white) expressed relative to the expected calibrated flow. For patient 1, a catheter thrombosis resulted in a dramatic flow decrease that was treated by a standard repermeabilization procedure (black arrow). Horizontal lines represent the +-10% accepted flow error. The red dot represents the ex-vivo flow rate of the withdrawn pump determined in experimental condition by refilling it with a 20 ml saline solution.
case_images: fmed-07-539707-g0002.jpg
case_images: PMC7662390_02_fmed-07-539707-g0002.jpg
case_images: F2
case_images: As with the first case we observed a progressive increase in treprostinil flow reaching 1.52 ml/day which is a 20% increase over the calibrated value of 1.27 ml/day (+- 10%) (Figure 2).
case_images: PMC7662390_02
case_images: Treprostinil delivery flow rate by the LenusPro  pump for patient 1 (black) and patient 2 (white) expressed relative to the expected calibrated flow. For patient 1, a catheter thrombosis resulted in a dramatic flow decrease that was treated by a standard repermeabilization procedure (black arrow). Horizontal lines represent the +-10% accepted flow error. The red dot represents the ex-vivo flow rate of the withdrawn pump determined in experimental condition by refilling it with a 20 ml saline solution.
case_images: fmed-07-539707-g0002.jpg
case_images: PMC7662390_02_fmed-07-539707-g0002.jpg
case_images: F2
case_images: As with the first case we observed a progressive increase in treprostinil flow reaching 1.52 ml/day which is a 20% increase over the calibrated value of 1.27 ml/day (+- 10%) (Figure 2).