case_images: PMC5903120_01
case_images: Prominent, infiltrated erythema on the left lower leg (a). Increased levels of standard uptake at the right inguinal lymph nodes (b). Atypical lymphoid cells densely infiltrated from the upper dermis to the subcutaneous tissue without epidermotropism (H&E staining; original magnification x50 [c], x400 [d]). Six months after the administration of bexarotene, the infiltrated erythema on the left lower leg had regressed (e) and the levels of standard uptake at right inguinal lymph nodes were normal (f).
case_images: cro-0011-0212-g01.jpg
case_images: PMC5903120_01_cro-0011-0212-g01.jpg
case_images: F1
case_images: On her initial visit, physical examination revealed prominent, infiltrated erythema on the bilateral lower legs (Fig. 1a). In addition, PET-CT scan revealed increased levels of standard uptake at the right axillary, left subclavicular, left internal deep cervical, and right inguinal lymph nodes (Fig. 1b). A biopsy specimen from the left lower leg revealed atypical lymphoid cells densely infiltrated from the upper dermis to the subcutaneous tissue without epidermotropism (Fig. 1c, d). Six months after the administration of bexarotene, all infiltrated erythemas had disappeared together with the pigmentation and scarring (Fig. 1e). Moreover, follow-up PET-CT scan revealed normal levels of standard uptake at all lymph nodes (Fig. 1f).