case_images: PMC4697093_01
case_images: Chest computed tomography scan in lung window shows a well-circumscribed large solid mass.
case_images: CRIPA2015-209490.001.jpg
case_images: PMC4697093_01_CRIPA2015-209490.001.jpg
case_images: fig1
case_images: A computed tomography (CT) scan confirmed the presence of a solid mass measuring 14 x 7.5 x 9 cm occupying the fissure between the right middle and lower lobe (Figure 1).
case_images: Large homogenous solid mass completely resected (macroscopic view).
case_images: CRIPA2015-209490.002.jpg
case_images: PMC4697093_01_CRIPA2015-209490.002.jpg
case_images: fig2
case_images: The mass increased in size by 75% compared with a CT scan performed a year earlier (Figure 2).
case_images: The spindle cells show strong and diffuse positivity for CD34. x100 magnification.
case_images: CRIPA2015-209490.003.jpg
case_images: PMC4697093_01_CRIPA2015-209490.003.jpg
case_images: fig3
case_images: The right lung was fully mobilised and the mass completely excised and sent for histological analysis (Figure 3).
case_images: The spindle cells show strong and diffuse positivity for Bcl-2. x100 magnification.
case_images: CRIPA2015-209490.004.jpg
case_images: PMC4697093_01_CRIPA2015-209490.004.jpg
case_images: fig4
case_images: Areas of hypercellularity, nuclear atypia, 18 mitoses per 10 high-power fields, and haemorrhagic and necrotic transformation were also identified, which confirmed that malignant transformation of a benign tumour had occurred (Figures 4, 5, and 6).
case_images: Tumour showing areas of hypocellularity and dense collagenous stroma. x200 magnification.
case_images: CRIPA2015-209490.005.jpg
case_images: PMC4697093_01_CRIPA2015-209490.005.jpg
case_images: fig5
case_images: Areas of hypercellularity, nuclear atypia, 18 mitoses per 10 high-power fields, and haemorrhagic and necrotic transformation were also identified, which confirmed that malignant transformation of a benign tumour had occurred (Figures 4, 5, and 6).
case_images: Spindle cells show marked nuclear atypia, overcrowding, and brisk mitotic activity. x400 magnification.
case_images: CRIPA2015-209490.006.jpg
case_images: PMC4697093_01_CRIPA2015-209490.006.jpg
case_images: fig6
case_images: Areas of hypercellularity, nuclear atypia, 18 mitoses per 10 high-power fields, and haemorrhagic and necrotic transformation were also identified, which confirmed that malignant transformation of a benign tumour had occurred (Figures 4, 5, and 6).