case_images: PMC3123911_01
case_images: (a, b) Breast MRI demonstrated regional enhancement in the left superior breast extending to the chest wall and diffuse skin thickening.
case_images: CRIM2011-738413.001.jpg
case_images: PMC3123911_01_CRIM2011-738413.001.jpg
case_images: fig1
case_images: Breast ultrasound revealed a solid mass in the 9 and 10 o'clock regions of the left breast, and breast MRI demonstrated diffuse enhancement in the left medial superior breast which extended to the chest wall (Figure 1).
case_images: (a, b) The breast biopsy demonstrated an invasive adenocarcinoma with a focal cribriform pattern, hyperchromatic round to oval nuclei, and brisk mitotic activity (H&E, 100x, 200x). (c) Cytokeratin 20 showed diffuse, positive staining in the tumor (cytokeratin 20, 100x). (d) CDX2, specific for intestinal epithelium, exhibited diffuse nuclear immunoreactivity in the tumor cells (CDX2, 200x).
case_images: CRIM2011-738413.002.jpg
case_images: PMC3123911_01_CRIM2011-738413.002.jpg
case_images: fig2
case_images: The patient underwent core needle biopsy which revealed a poorly differentiated adenocarcinoma (Figure 2) with neither an in situ component nor lymphovascular space invasion. The tumor was positive for CK20 and CDX-2 (Figure 2), and negative for CK-7, estrogen receptor, progesterone receptor, and HER2/neu by immunohistochemistry and fluorescent in situ hybridization (FISH).