case_images: PMC11206225_01
case_images: Metabolic map of brain Positron Emission Tomography with [18F]fluordeoxyglucose (FDG PET) showing asymmetric, left-predominant glycolytic hypometabolism in the middle frontal gyrus, anterior cingulate, accessory and supplementary motor cortex, as well as the dorsomedial prefrontal cortex, a pattern highly suggestive of a primary tauopathy.
case_images: 1980-5764-DN-18-e20230085-gf01.jpg
case_images: PMC11206225_01_1980-5764-DN-18-e20230085-gf01.jpg
case_images: f1
case_images: As this was an atypical dementia syndrome of early onset, an FDG PET was requested, which revealed asymmetric, left-predominant glycolytic hypometabolism in the middle frontal gyrus, anterior cingulate, accessory and supplementary motor cortex, as well as the dorsomedial prefrontal cortex, a pattern highly suggestive of a primary tauopathy (Figure 1).
case_images: PMC11206225_02
case_images: Clock Drawing Test in case 2, revealing serious difficulties in the spatial distribution of numbers and poor planning to perform the task.
case_images: 1980-5764-DN-18-e20230085-gf02.jpg
case_images: PMC11206225_02_1980-5764-DN-18-e20230085-gf02.jpg
case_images: f2
case_images: She scored 21/30 on the MMSE, and 18/30 on the Montreal Cognitive Assessment (MoCA) and showed significant visuospatial impairment on the Clock Drawing Test (Figure 2).
case_images: Metabolic map of brain Positron Emission Tomography with [18F]fluordeoxyglucose (FDG PET) study of case 2 revealing significant asymmetric, right-predominant glycolytic hypometabolism affecting posterior parietal regions and precuneus.
case_images: 1980-5764-DN-18-e20230085-gf03.jpg
case_images: PMC11206225_02_1980-5764-DN-18-e20230085-gf03.jpg
case_images: f3
case_images: Brain FDG PET showed significant asymmetric, right-predominant glycolytic hypometabolism affecting posterior parietal regions and precuneus (Figure 3).