case_images: PMC7350519_01
case_images: Multiple papulonodular skin lesions with predilection for cheeks.
case_images: fonc-10-00921-g0001.jpg
case_images: PMC7350519_01_fonc-10-00921-g0001.jpg
case_images: F1
case_images: On physical examination at admission, disseminated, single, pearly yellow nodules localized on the face, trunk, and extremities (Figure 1); bruises; and significant hepatosplenomegaly were found.
case_images: Histiocyte proliferation in the bone marrow of patient in remission of acute lymphoblastic leukemia (ALL); magnification, x1,000.
case_images: fonc-10-00921-g0002.jpg
case_images: PMC7350519_01_fonc-10-00921-g0002.jpg
case_images: F2
case_images: Bone marrow examination confirmed persistent complete remission with negative MRD of <0.01%; however, an increased number of histiocytes with hemophagocytosis (Figures 2, 3) was seen in bone marrow.
case_images: Hemophagocytosis in bone marrow; magnification, x1,000.
case_images: fonc-10-00921-g0003.jpg
case_images: PMC7350519_01_fonc-10-00921-g0003.jpg
case_images: F3
case_images: Bone marrow examination confirmed persistent complete remission with negative MRD of <0.01%; however, an increased number of histiocytes with hemophagocytosis (Figures 2, 3) was seen in bone marrow.
case_images: Skin biopsy revealed diffuse infiltration by histiocytes positive for CD45 and CD68 and negative for S100 and CD1a. Hematoxylin-eosin stain; magnification, x10.
case_images: fonc-10-00921-g0004.jpg
case_images: PMC7350519_01_fonc-10-00921-g0004.jpg
case_images: F4
case_images: Skin biopsy revealed diffuse infiltration by histiocytes expressing CD45 and CD68 but negative for CD1a, langerin, and S100 (Figure 4); thus, JXG was recognized.