case_images: PMC10601725_01
case_images: Timeline that summarizing the main clinical events.
case_images: cro-2023-0016-0001-529859_F01.jpg
case_images: PMC10601725_01_cro-2023-0016-0001-529859_F01.jpg
case_images: F1
case_images: Figure 1 displays a timeline summarizing the main clinical events.
case_images: Histology of the core needle biopsy. a Low power (x2) demonstrates intraductal proliferations with scattered associated calcifications. b Higher power (x10) shows that the intraductal proliferations consist of a monomorphic population of cohesive cells forming bridges and micropapillary structures, consistent with a diagnosis of atypical ductal hyperplasia.
case_images: cro-2023-0016-0001-529859_F02.jpg
case_images: PMC10601725_01_cro-2023-0016-0001-529859_F02.jpg
case_images: F2
case_images: The left breast calcifications were recommended for a core needle biopsy, which reported atypical ductal hyperplasia (ADH; Fig. 2).
case_images: Histology of the breast excision. a A focus of invasive ductal carcinoma, grade 2, was identified (x2). b A higher power view at x20 of the invasive ductal carcinoma. c Immunostaining for estrogen receptor shows diffuse expression by the carcinoma cells (x20). Ductal carcinoma in situ of intermediate nuclear grade was also present (not shown). Refer to text for additional details regarding histologic findings.
case_images: cro-2023-0016-0001-529859_F03.jpg
case_images: PMC10601725_01_cro-2023-0016-0001-529859_F03.jpg
case_images: F3
case_images: Pathology of the excisional biopsy was upgraded to invasive cancer - a single focus of a 4 mm invasive ductal carcinoma (grade 2, ER+, PR+, and HER2-), and ductal carcinoma in situ (DCIS; intermediate nuclear grade) were identified (Fig. 3).
case_images: PMC10601725_02