case_images: PMC11745219_01
case_images: PMC11745219_02
case_images: Nodules in the periocular region.
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case_images: PMC11745219_02_gr1.jpg
case_images: fig0005
case_images: Linearly distributed nodules were observed bilaterally in the periocular and in the glabella region 16 weeks after starting pembrolizumab (Fig. 1).
case_images: (A) Ultrasonography showing hyperechoic areas coarsely nodular; (B) Histopathology showing a granulomatous inflammatory process, with giant cells in the dermis phagocytizing empty and round vacuoles of different sizes, without evidence of necrosis (Hematoxylin & eosin, x400).
case_images: gr2.jpg
case_images: PMC11745219_02_gr2.jpg
case_images: fig0010
case_images: Dermatological ultrasound showed bilateral subcutaneous thickening in the periorbital region, especially in the lateral aspects; a similar process was seen in the frontal and dorsal regions of the base of the nose (Fig. 2A).