case_images: PMC3647713_01
case_images: Major clinical events occurred in the patient after an ABO incompatible (donor A Rh+; recipient 0 Rh+) HLA matched sibling for beta-thalassemia major.
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case_images: PMC3647713_01_mjhid-5-1-e2013029f1.jpg
case_images: f1-mjhid-5-1-e2013029
case_images: Subsequent detections showed a progressive reduction of donor chimerism (60% on day + 80; 50% on day +100). (Figure 1) Two months and a half later (+150) reduced mixed chimerism was confirmed (50% of donor cells) and due to this, five increasing dose infusions (from 1x104/kg to 2x105/kg) of donor lymphocytes (DLI) were performed from September 2008 to February 2009, in order to further increase donor chimerism. In fact, chimerism studies on both peripheral blood and bone marrow showed a complete recipient chimerism, with the absence of donor-derived hematopoietic cells (Figure 1 and Figure 2).
case_images: White blood cells count of the patient after transplants.
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case_images: PMC3647713_01_mjhid-5-1-e2013029f2.jpg
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case_images: In fact, chimerism studies on both peripheral blood and bone marrow showed a complete recipient chimerism, with the absence of donor-derived hematopoietic cells (Figure 1 and Figure 2).