case_images: PMC7322166_01
case_images: (A) Cystoscopy image showing a neoplasm grown surrounding the distal urethra. (B) An ideograph displaying the appearance and invasion range of the tumor in the urethra.
case_images: OTT-13-6011-g0001.jpg
case_images: PMC7322166_01_OTT-13-6011-g0001.jpg
case_images: F0001
case_images: Cystoscopy revealed a tumor growing around the urethra about 1 cm from the external urethral meatus and biopsy was taken (Figure 1A). The tumor appeared to invade the corpus spongiosum (Figure 1B).
case_images: Microphotograph of the mass revealed high-grade urothelium carcinoma (hematoxylin-eosin, x 100 magnification (A) and x 200 magnification (B)).
case_images: OTT-13-6011-g0002.jpg
case_images: PMC7322166_01_OTT-13-6011-g0002.jpg
case_images: F0002
case_images: Histopathologic examination reported urothelial hyperplasia and squamous cell differentiation arranged in papilla (Figure 2).
case_images: Immunohistochemistry of the tumor revealing: P16(-) (A), P53(partly+) (B), CK7(+) (C), CK8(+) (D), CK20(-) (E), UroplakinII(-) (F), P63(+) (G), Ki-67(+,50%) (H).
case_images: OTT-13-6011-g0003.jpg
case_images: PMC7322166_01_OTT-13-6011-g0003.jpg
case_images: F0003
case_images: Immunohistochemical analysis was carried out and reported as following: P16(-), P53(partly+), CK7(+), CK8(+), CK20(-), UroplakinII(-), P63(+), Ki-67(+,50%), confirming the diagnosis of high-grade papillary urothelium carcinoma (Figure 3).