case_images: PMC10602774_01
case_images: (A) A cerebral MRI taken in 2005, suggestive of medial temporal sclerosis approximately 20 years after recovery from distinct amnesia and both ante- and retrograde affection. (B) Antibody titres over time.
case_images: fneur-14-1237140-g001.jpg
case_images: PMC10602774_01_fneur-14-1237140-g001.jpg
case_images: fig1
case_images: Cerebral MRI in 2005 was suggestive of bilateral hippocampal sclerosis (Figure 1A). Both anti-AMPAR and anti-Lgi1 antibodies persisted in low concentrations for the next 25 years (Figure 1B).
case_images: Immunohistochemical examination of thymoma from (A), our patient and (B), a control for GluR2 (left) and Lgi1 (right) showing similar staining pattern.
case_images: fneur-14-1237140-g002.jpg
case_images: PMC10602774_01_fneur-14-1237140-g002.jpg
case_images: fig2
case_images: Lgi1 (Anti-LGI1 Rabbit Antibody, Sigma Aldrich, #PRS4489) (Figure 2). Lymphoepitheliomas from three patients with myasthenia gravis with no encephalitic serum antibodies and not suffering from encephalitis were tested with the same antibodies, and all showed similar staining.