case_images: PMC4918376_01
case_images: Low-power photomicrograph of patient's original glioblastoma showing pseudopalisading necrosis (A) and proliferative endothelium (B).. Note: Hematoxylin and eosin stain; x220.
case_images: ov-4-033Fig1.jpg
case_images: PMC4918376_01_ov-4-033Fig1.jpg
case_images: f1-ov-4-033
case_images: Neuropathologic examination revealed a GBM with an infiltrative glial tumor, with neoplastic astrocytes exhibiting nuclear pleomorphism and hyperchromatosis, along with elements of endothelial proliferation, necrosis, and pseudopalisading architecture (Figure 1A and B).
case_images: Axial, coronal, and sagittal T1 gadolinium enhanced magnetic resonance images before oncolytic HSV treatment (A-C) and at five year follow-up (D-F).. Abbreviations: 5yr F/U, 5-year follow-up; HSV, herpes simplex virus.
case_images: ov-4-033Fig2.jpg
case_images: PMC4918376_01_ov-4-033Fig2.jpg
case_images: f2-ov-4-033
case_images: The patient chose to participate in a Phase III study and was randomized to the standard treatment arm, not receiving any experimental therapy at that time (Figure 2A-F).
case_images: Photomicrograph of hematoxylin and eosin-stained representative tissue from 1998 (post-G207 treatment) resection, demonstrating areas of coagulative necrosis, perivascular inflammation, edema, astrocytosis, and foamy macrophages consistent with treatment effect.. Note: Atypical cells seen could represent inflammation, but tumor is not excluded; x200.
case_images: ov-4-033Fig3.jpg
case_images: PMC4918376_01_ov-4-033Fig3.jpg
case_images: f3-ov-4-033
case_images: Neuropathologic examination of the resected material identified areas of coagulative necrosis, perivascular inflammation, edema, astrocytosis, and foamy macrophages treatment effect (Figure 3).