case_images: PMC11419970_01
case_images: Preoperative (A-C) and postoperative (D-F) coronal T1 (A, D) and T2 (B, C, E, F) MRI images.
case_images: fonc-14-1448213-g001.jpg
case_images: PMC11419970_01_fonc-14-1448213-g001.jpg
case_images: f1
case_images: T2-weighted that occupied the entire right nasal fossa, obstructing the drainage of the paranasal sinuses and causing an erosion of the medial bony wall of the nasolacrimal duct ( Figure 1 ). There was no orbital or intracranial invasion or lymph node metastasis. Based on these findings, an endoscopic approach with complete tumor resection ( Figure 1 ) and adjuvant radiotherapy was performed.
case_images: Histology (Hematoxylin and Eosin) and some of the most relevant immunohistochemical stains. Magnification x20.
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case_images: PMC11419970_01_fonc-14-1448213-g002.jpg
case_images: f2
case_images: Histopathological examination showed a lobulated basaloid tumor with comedonecrosis and monotonous basophilic cells that formed nests with mucinous spaces and that, in isolation, showed formation of ductal structures ( Figure 2 ). Immunohistochemical study showed a predominantly myoepithelial tumor cell population with expression of S-100, SOX-10, p40, p63, SMA and Pan cytokeratin (AE1/AE3) ( Figure 2 ). The ductal component showed intense positivity for CK8 ( Figure 2 ). cMYB expression was moderate and variable ( Figure 3 ).
case_images: Other of the most important stains. Magnification x20.
case_images: fonc-14-1448213-g003.jpg
case_images: PMC11419970_01_fonc-14-1448213-g003.jpg
case_images: f3
case_images: The ductal component showed intense positivity for CK8 ( Figure 2 ). cMYB expression was moderate and variable ( Figure 3 ). In situ hybridization assay for the detection of viral E6/E7 RNA was diffusely positive confirming that HPV 35 was transcriptionally active ( Figure 3 ).
case_images: Copy number analysis: A high-level gain is observed at 6q23.
case_images: fonc-14-1448213-g004.jpg
case_images: PMC11419970_01_fonc-14-1448213-g004.jpg
case_images: f4
case_images: At 6q23 where MYB is located, a high-level gain could be observed ( Figure 4 ).