case_images: PMC3915439_01
case_images: PMC3915439_02
case_images: Photomicrographs of peripheral smears of the patient showing microcytic hypochromic red cells with target cells, basophilic stippling and moderate anisopoikilocytosis (a & b, Giemsa x400). HPLC graph demonstrated 100% HbF in the child with absent HbA and HbA2 (c
case_images: ijpho-3-222-g001.jpg
case_images: PMC3915439_02_ijpho-3-222-g001.jpg
case_images: F1
case_images: Peripheral smear examination showed microcytic hypochromic red cells with target cells and polychromasia (Fig. 1a,b). An HPLC analysis was carried out, which revealed 100% HbF with absence of HbA and HbA2 (Fig. 1c).
case_images: Peripheral blood smear of the father shows few microcytic hypochromic red cells (a, Giemsa x400) while HPLC shows elevated HbF (b). Peripheral blood smear of mother showing microcytic hypochromic red cells and occasional target cells (c, Giemsa x400) and HPLC graph with HbF of 16.0% (d).
case_images: ijpho-3-222-g002.jpg
case_images: PMC3915439_02_ijpho-3-222-g002.jpg
case_images: F2
case_images: The smear of both parents also showed hypochromia and target cells (Fig. 2a-d).