case_images: PMC4168687_01
case_images: Conceptual methodology for determination of dose. Theoretical 7-step compartmentalization of decision workflow (left column) and implementation considerations specific to this case study of a 10 year-old child with hemiparesis due to perinatal stroke (right column). Incorporation of prior experience in the dose decision process coupled with modeling allows value-determination of subject-specific dose decisions for implementation.
case_images: fnhum-08-00739-g0001.jpg
case_images: PMC4168687_01_fnhum-08-00739-g0001.jpg
case_images: F1
case_images: This involves integration of prior clinical trials and modeling; (1) with the subject specific information, desired clinical outcome, constraints and current flow criterion (Figure 1).