case_images: PMC4101939_01
case_images: Macroscopic view of the enlarged spleen, nodular appearance (arrow).
case_images: CRIONM2014-193036.001.jpg
case_images: PMC4101939_01_CRIONM2014-193036.001.jpg
case_images: fig1
case_images: The spleen was 1.200 g in weight and 19 x 15 x 11 cm in size, with nodular appearance and areas of necrosis (Figure 1).
case_images: Microscopic view of splenic angiosarcoma (Hematoxylin-Eosin stain, H-E x200). Area of atypical endothelial cells with significant irregular hyperchromatic nuclei (green arrow), area of necrosis (red arrow).
case_images: CRIONM2014-193036.002.jpg
case_images: PMC4101939_01_CRIONM2014-193036.002.jpg
case_images: fig2
case_images: The final histopathological diagnosis was angiosarcoma originating from the spleen (Figures 2 and 3).
case_images: Microscopic image of the same lesion (H-E x400), disorganized anastomosing vascular channels lined by large, atypical endothelial cells (green arrow).
case_images: CRIONM2014-193036.003.jpg
case_images: PMC4101939_01_CRIONM2014-193036.003.jpg
case_images: fig3
case_images: The final histopathological diagnosis was angiosarcoma originating from the spleen (Figures 2 and 3).
case_images: Immunohistochemical stain of angiosarcoma of the spleen (CD34 x400).
case_images: CRIONM2014-193036.004.jpg
case_images: PMC4101939_01_CRIONM2014-193036.004.jpg
case_images: fig4
case_images: Immunohistochemical staining was positive for vimentin, CD31, CD34 (Figure 4), and factor VIII (Figure 5) and negative for CD68.
case_images: Immunohistochemical stain of angiosarcoma of the spleen (factor VIII x400).
case_images: CRIONM2014-193036.005.jpg
case_images: PMC4101939_01_CRIONM2014-193036.005.jpg
case_images: fig5
case_images: Immunohistochemical staining was positive for vimentin, CD31, CD34 (Figure 4), and factor VIII (Figure 5) and negative for CD68.