case_images: PMC10627061_01
case_images: Clinical photograph of the patient demonstrating erythematous plaques and desquamation. (A) On February 27, 2020, the patient developed red rashes on the upper limbs, the front chest, and the back. The rashes were slightly raised above the skin and were not accompanied by itching. (B) On March 6, 2020, the patient's blisters around the mouth, back, and limbs progressed more than before, and the skin on the neck began to peel off. (C) On March 10, 2020, the patient experienced skin peeling on the head, neck, back, and buttocks, with significant pain, and new blisters appeared on the lower limbs. (D) On March 15, 2020, the patient's skin peeling worsened. Skin peeling was also observed on the external genitalia and around the anus, with bright red skin exposed, accompanied by exudation.
case_images: JIR-16-5061-g0001.jpg
case_images: PMC10627061_01_JIR-16-5061-g0001.jpg
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case_images: On 27 February 2020, the patient was diagnosed with a vesicular rash on the skin that had spread to the upper limbs, chest, and dorsum (Figure 1A). Although the body temperature decreased to 38  C on 3rd March, the vesicles in back and limbs enlarged, and the neck skin began to desquamate (Figure 1B). The desquamation had spread to multiple regions of the head, neck, back, buttocks, and limbs with pain since 10th March, and this condition took 1 week to improve (Figure 1C and D).
case_images: Clinical photograph of the patient recovering from SJS. (A) On March 19, 2020, the patient's skin exudation began to decrease. (B) On March 23, 2020, the patient's skin gradually became dry and started to heal. (C) On March 30, 2020, the patient's skin further healed and was dry without exudation, with only a small amount of bright red skin exposed on the buttocks. (D) On April 6, 2020, the patient's skin damage was significantly healed.
case_images: JIR-16-5061-g0002.jpg
case_images: PMC10627061_01_JIR-16-5061-g0002.jpg
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case_images: Hence, methylprednisolone was reduced to 80 mg Q12h from 19th March (Figure 2A). Exudation decreased significantly starting 23rd March (Figure 2B and C), and skin-associated symptoms returned to near-normal levels (Figure 2D).
case_images: CT scans of the tumor before and after treatment with Sintilimab.
case_images: JIR-16-5061-g0003.jpg
case_images: PMC10627061_01_JIR-16-5061-g0003.jpg
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case_images: On 6th April, the lump in the right lower lung slightly reduced in dimension from 2.7 cm to 2.4 cm (11%) compared to the former CT scan (Figure 3).