case_images: PMC11250155_01
case_images: IJCN. a Clinical photograph demonstrating a nonpigmented conjunctival lesion adjacent to the limbus. b Tumor invasion into the globe is not observed on anterior segment optical coherence tomography.
case_images: cop-2024-0015-0001-538593_F01.jpg
case_images: PMC11250155_01_cop-2024-0015-0001-538593_F01.jpg
case_images: F1
case_images: A 13-year-old female patient presented with a bulbar juxtalimbal conjunctival nonpigmented inflammatory tumor (Fig. 1a). No tumor invasion into the globe was observed on anterior segment optical coherence tomography (Fig. 1b).
case_images: Pathological images of IJCN. a Excisional biopsy histology (H&E, x100) demonstrating a prominent and dense infiltrate of nevus cells and cyst formation (yellow arrow) within the conjunctival epithelium with lymphocyte infiltration forming a lymphoid follicle (red arrow). b Excisional biopsy histology (H&E, x200) demonstrating a congregation of small foci consisting of nevus cells with moderately irregular nuclei. c Nevus cells stain positive with SOX10 (SOX10, x100).
case_images: cop-2024-0015-0001-538593_F02.jpg
case_images: PMC11250155_01_cop-2024-0015-0001-538593_F02.jpg
case_images: F2
case_images: Dense lymphoid infiltration with lymphoid follicles was also observed (Fig. 2a). Higher-magnification examination showed a congregation of small foci consisting of nevus cells with moderately irregular nuclei (Fig. 2b). Immunohistochemically, nevus cells were positive for HMB-45 and SOX10 (Fig. 2c), and negative for AE1/AE3 and BRAF V600E.