case_images: PMC10851032_01
case_images: Abdominal X-ray anteroposterior projection in the standing position. The abdominal X-ray reveals intestinal loop dilatation and gas-filled loops.
case_images: cureus-0016-00000051888-i01.jpg
case_images: PMC10851032_01_cureus-0016-00000051888-i01.jpg
case_images: FIG1
case_images: An abdominal X-ray was taken in a standing position, revealing signs of intestinal obstruction, such as intestinal loops dilatation and gas-filled loops (Figure 1).
case_images: Intraoperative findings. Signs of ischemia (IS) and edema are observed in the ileo-ileal intestinal invagination caused by Meckel's diverticulum.
case_images: cureus-0016-00000051888-i02.jpg
case_images: PMC10851032_01_cureus-0016-00000051888-i02.jpg
case_images: FIG2
case_images: During the procedure, an ileo-ileal intussusception was discovered approximately 30 cm from the ileocecal valve, resulting from a Meckel's diverticulum with a pedunculated polyp (Figure 2).
case_images: Microscopy image H&E staining of Meckel's diverticulum. A) (10x), B) (40x). It reveals the presence of glandular structures that consist of cuboidal cells, which collectively form the pancreatic acini (PA) exhibiting intense hematoxylin staining. In addition, the image reveals the existence of islets of Langerhans (IL), comprising polygonal cells with voluminous and pale cytoplasm and monomorphic nuclei with classic salt and pepper chromatin. Furthermore, the pancreatic ducts are visible, lined with low cuboidal epithelium that has uniform nuclei alternating with the pancreatic acini. The tissue in question is classified as an ectopic pancreatic tissue type 1 as per the Heinrich classification, owing to the presence of centroacinous cells (CC), excretory ducts (ED), and IL.
case_images: cureus-0016-00000051888-i03.jpg
case_images: PMC10851032_01_cureus-0016-00000051888-i03.jpg
case_images: FIG3
case_images: The hematoxylin and eosin staining analysis of the histological section revealed a Meckel's diverticulum with Heinrich type 1 ectopic pancreatic tissue implantation, and no signs of malignancy were found (Figure 3).
case_images: Positive synaptophysin immunostaining (10x). It exhibits a diffuse pattern of cytoplasmic decoration of the neuroendocrine cells present in the islets of Langerhans (IL). This study shows the molecular characteristics of an ectopic pancreas in Meckel's diverticulum.
case_images: cureus-0016-00000051888-i04.jpg
case_images: PMC10851032_01_cureus-0016-00000051888-i04.jpg
case_images: FIG4