case_images: PMC2825517_01
case_images: Multi-detector computed tomography (CT) thorax and abdomen with intravenous contrast enhancement showing hepatosplenomegaly, axillary and abdominal lymphadenopathy.
case_images: 1752-1947-4-32-1.jpg
case_images: PMC2825517_01_1752-1947-4-32-1.jpg
case_images: F1
case_images: A CT scan showed hepato-splenomegaly and gross lymphadenopathy involving the thorax, abdomen and pelvis (Figure 1).
case_images: Inguinal lymph node biopsy: histology characteristic of MCD: (A) Haematoxylin & Eosin stained section of lymph node (original magnification x 2.5) showing effaced architecture with few residual follicles. (B) infiltration with large blastic cells (PB, original magnification x 60). (C) Immunostaining reveals blastic cells express HHV-8 (positive cells are brown, original magnification x 60).
case_images: 1752-1947-4-32-2.jpg
case_images: PMC2825517_01_1752-1947-4-32-2.jpg
case_images: F2
case_images: Inguinal lymph node excision biopsy confirmed the clinical suspicion of Multi-centric Castleman's disease (MCD) (Figure 2).
case_images: Chest X-ray showing bilateral diffuse infiltrates.
case_images: 1752-1947-4-32-3.jpg
case_images: PMC2825517_01_1752-1947-4-32-3.jpg
case_images: F3
case_images: The chest radiograph progressed over four days to bilateral diffuse patchy consolidation (Figure 3), associated with greatly increased oxygen requirements (FiO2 0.8), and consistent with a diagnosis of acute respiratory distress syndrome (ARDS).