case_images: PMC8147557_01
case_images: (A) Sanger sequence of UBA1. (B.I) Episcleritis, nose chondritis. (B.II) Urticarial lesion of the neck. (B.III-V) Nodular lesions on extremities and abdomen: biopsy-confirmed complement-mediated vasculopathy. (B.VI) Episcleritis, periorbital erythema (B.VII) Urticarial vasculitis of gluteal region. (C) Representative aberrant vacuolized bone marrow cells (x40 magnification); left panel also a normal band neutrophil, third panel also a normal erythroblast.
case_images: fimmu-12-678927-g001.jpg
case_images: PMC8147557_02_fimmu-12-678927-g001.jpg
case_images: f1
case_images: Patient 2 (Figure 1A and Table 1) is a 76-year-old male. He presented with a recurrent rash and a symmetric polyarthritis of both large and small joints (Figure 1B.VI-VII). Bone marrow examination (Figure 1C and Table 1) showed trilineage dysplasia with myeloid vacuolization and reactive plasmocytosis without evidence of a plasma cell dyscrasia.
case_images: PMC8147557_02
case_images: (A) Sanger sequence of UBA1. (B.I) Episcleritis, nose chondritis. (B.II) Urticarial lesion of the neck. (B.III-V) Nodular lesions on extremities and abdomen: biopsy-confirmed complement-mediated vasculopathy. (B.VI) Episcleritis, periorbital erythema (B.VII) Urticarial vasculitis of gluteal region. (C) Representative aberrant vacuolized bone marrow cells (x40 magnification); left panel also a normal band neutrophil, third panel also a normal erythroblast.
case_images: fimmu-12-678927-g001.jpg
case_images: PMC8147557_02_fimmu-12-678927-g001.jpg
case_images: f1
case_images: Patient 2 (Figure 1A and Table 1) is a 76-year-old male. He presented with a recurrent rash and a symmetric polyarthritis of both large and small joints (Figure 1B.VI-VII). Bone marrow examination (Figure 1C and Table 1) showed trilineage dysplasia with myeloid vacuolization and reactive plasmocytosis without evidence of a plasma cell dyscrasia.