case_images: PMC11377932_01
case_images: The 1
  st patient rapid progression of venous ulcer healing.. A. pre-EVLA; B. 1-week post-EVLA.
case_images: f1000research-12-171959-g0000.jpg
case_images: PMC11377932_01_f1000research-12-171959-g0000.jpg
case_images: f1
case_images: On physical examination of the medial side of the right ankle region, there was a solitary ulcer, sized 3x4 cm with irregular edges, erythema ulcer base accompanied by purulent discharge, dry distant tissue, edema (+), and hyperpigmentation on 1/3 mid of the lower leg until dorsal side of the foot ( Figure 1A). The patient's condition was assessed one week after EVLA, and she reported no more pain, significant rapid improvement of the ulcer, granulation tissue (+), and no more discharge ( Figure 1B).
case_images: PMC11377932_02
case_images: Venous leg ulcer healing progression of the 2
  nd patient.. A. pre-EVLA; B. 6-months post EVLA.
case_images: f1000research-12-171959-g0001.jpg
case_images: PMC11377932_02_f1000research-12-171959-g0001.jpg
case_images: f2
case_images: Physical examination of the left ankle region showed multiple ulcers sized 18x10 cm on the medial side, 8x5 cm, and 4x2 cm on the lateral side with irregular edges ( Figure 2A).
case_images: Lower extremity duplex ultrasound of the 2
  nd patient.. A. Obliterated segment of above-the-knee left GSV;. B. persistent reflux of below-the-knee GSV (968 ms).
case_images: f1000research-12-171959-g0002.jpg
case_images: PMC11377932_02_f1000research-12-171959-g0002.jpg
case_images: f3
case_images: Lower extremity DUS revealed perfectly obliterated proximal until distal ATK left GSV, severe reflux (duration >1000 ms) on BTK left GSV, common femoral vein, popliteal vein, and accessory veins of both lower limbs, and moderate reflux (duration 500 ms - 1000 ms) in right GSV ( Figure 3).
case_images: PMC11377932_03
case_images: Venous leg ulcer healing progression of the 3
  rd patient.. A. pre-EVLA; B. 6-months post EVLA.
case_images: f1000research-12-171959-g0003.jpg
case_images: PMC11377932_03_f1000research-12-171959-g0003.jpg
case_images: f4
case_images: Physical examination showed multiple ulcers sized 10x8 cm at lateral side of the right ankle and 8x3 cm at medial side of the right ankle with irregular edge, wet base with purulent discharge, erythema, edema (+), and hyperpigmentation from 1/3 proximal of the right lower leg until dorsal side of the lower foot ( Figure 4A). There was no ulcer left, hyperpigmentation was limited to 1/3 proximal of the right lower leg, and there was a scar (+) on the previously ulcerous region ( Figure 4B).