case_images: PMC11148205_01
case_images: Imaging and Histopathological Findings of Ovarian mGCTs. (A) An ultrasound scan highlights the absence of the left ovary and reveals a 15 cm x 13 cm x 9 cm heterogeneous hypoechoic mass behind the uterus in the pelvic midline. (B) An abdominal enhanced CT scan depicts a large, irregularly dense mass within the abdomen and pelvis, with solid components showing slight contrast enhancement and cystic components exhibiting no enhancement. The histopathological aspects include (C) a slide of non-germinomatous germ cell tumor tissue and (D) a yolk sac tumor tissue section, both stained with hematoxylin and eosin (H&E) at x200 magnification. Immunohistochemical staining demonstrates (E) CD117 positivity and (F) SALL4 positivity. (G) A postoperative 18F-FDG PET/CT scan shows postsurgical changes in the left adnexal region with no evidence of enlarged or hypermetabolic lymph nodes in the abdominal, pelvic, or retroperitoneal areas.
case_images: fonc-14-1360158-g001.jpg
case_images: PMC11148205_01_fonc-14-1360158-g001.jpg
case_images: f1
case_images: Abdominal ultrasound and CT scan revealed a pelvic mass ( Figures 1A, B ). Pathological examination revealed left ovarian mGCTs (80% dysgerminoma + 20% yolk sac tumor) ( Figures 1C-F ), and cytology of the ascitic fluid showed no atypical cells. PET/CT showed no abnormal metabolic activity in the sellar region or the surgical area in the left adnexa, while the rest of the body showed no abnormalities ( Figure 1G ).
case_images: Imaging and Histopathology of Sellar mGCTs. (A, B) MRI images exhibit heterogeneous signal intensities in the sellar area with iso/slightly low signals on T1 and T2-weighted images. (C) Post-contrast scans reveal mild, uneven enhancement in the affected area. The histopathological findings are detailed in (D) a histological slide of the sellar germ cell tumor, and (E) a yolk sac tumor section, both stained with H&E at x200 magnification. Immunohistochemical staining shows (F) OCT 3/4 positivity and (G) AFP positivity. Finally, (H) a follow-up MRI at 6 months post-treatment confirms no signs of tumor recurrence in the sellar region.
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case_images: PMC11148205_01_fonc-14-1360158-g002.jpg
case_images: f2
case_images: T1-weighted and T2-weighted images, heterogeneous enhancement after contrast administration, compression of the optic chiasm, left deviation of the pituitary stalk ( Figures 2A-C ). The initial diagnosis upon admission was metastatic tumor in the sellar region or pituitary adenoma. Figures 2D-G ). Following surgery, the patient's headaches resolved and visual disturbances significantly improved. After six months of follow-up, the patient's condition remained stable; tumor markers were within normal limits; abdominal contrast-enhanced CT showed postoperative changes in the left adnexa; and sellar MRI revealed no tumor recurrence ( Figure 2H ).