case_images: PMC4835629_01
case_images: Preoperative sagittal MRI shows the spinal cord tumor at the level of the conus medullaris (arrow). T1-weighted MRI with gadolinium shows high signal intensity relative to that of the cord (a) and T2-weighted MRI shows inhomogenous hypointensive signal (b). Four weeks' follow-up sagittal T1-weighted MRI with gadolinium (c) and T2-weighted MRI (d) and 28 weeks' follow-up T1-weighted MRI with gadolinium (e) and T2-weighted MRI (f) show the residual tumor (arrow).
case_images: CRIONM2016-3815280.001.jpg
case_images: PMC4835629_01_CRIONM2016-3815280.001.jpg
case_images: fig1
case_images: It was hyperintense on gadolinium enhanced T1-weighted images (Figure 1(a)) and inhomogenous and hypointensive on T2-weighted images (Figure 1(b)). Due to diffuse tumoral infiltration and probable severe postoperative deficits the tumor was incompletely removed with decompression of the neurologic structures (Figures 1(c) and 1(d)).
case_images: Illustration of the histology (H&E) and immunohistochemistry (HMB-45) of the investigated tumor. Tumor cells are polygonal with prominent nucleoli and partially pigmented (H&E). Tumor cells express the melanoma specific protein HMB-45. Tumor cells were also positive for MELAN-A and S-100 (not shown). Scale bars represent 100 mum; magnification x400 each.
case_images: CRIONM2016-3815280.002.jpg
case_images: PMC4835629_01_CRIONM2016-3815280.002.jpg
case_images: fig2
case_images: They were positive for Melan-A with a mib-labeling index ranging from 5% to 10%.  Figure 2 illustrates histopathology and immunohistochemistry of the investigated tumor.