case_images: PMC10859491_01
case_images: The diagnosis and treatment process of DIHH. (A) The abdominal ultrasonography indicated diffusely heterogeneous hepatomegaly with diffused rounded hypoechoic lesions. (B) The MRI revealed diffuse lesions with hyperintense pattern on the T2-weighted images in the liver. (C-E) The MRI indicates a continuous regression in the lesions during the 6 months follow-up, and ultimately reaching complete remission (CR).
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case_images: PMC10859491_01_fonc-14-1336742-g001.jpg
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case_images: Abdominal ultrasonography (US) indicated diffusely heterogeneous hepatomegaly with diffused rounded hypoechoic lesions ( Figure 1A ). The MRI revealed diffuse lesions with the hypointense pattern on the T1-weighted images and hyperintense pattern on the T2-weighted images in the liver ( Figure 1B ). Most lesions were significantly regressed, and some lesions shrunk after three months of treatment ( Figure 1C ). The patient was persistently responsible for the current treatment and achieved near-complete remission after six months of treatment ( Figure 1D ). The intrahepatic lesions were completely regressed after one year of treatment and the patient was developing well ( Figure 1E ). The detailed diagnosis and treatment process is shown in  Figure 1 .
case_images: The pathological finding of DIHH. (A) Hematoxylin and eosin staining identified a large number of proliferating vascular endothelial cells at 200x magnification. (B-D) Immunohistochemical analysis indicated that tumor cells were immunoreactive for CD34 (B) and CD31 (C), low Ki-67 index (D) at the magnification of x200.
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case_images: PMC10859491_01_fonc-14-1336742-g002.jpg
case_images: f2
case_images: Hematoxylin and eosin (HE) staining revealed that the tumor was composed of several proliferating vascular endothelial cells ( Figure 2A  ). Immunohistochemical analysis showed positive staining for CD31 and CD34 ( Figures 2B, C ), with a low Ki-67 index ( Figure 2D ).