case_images: PMC6395054_01
case_images: Radiographs of posterior spinal correction surgery.. Notes: She underwent posterior spinal correction surgery for scoliosis at 12 years of age. Radiographs show (A) anterior-posterior view and (B) lateral view.
case_images: tcrm-15-303Fig1.jpg
case_images: PMC6395054_01_tcrm-15-303Fig1.jpg
case_images: f1-tcrm-15-303
case_images: She underwent posterior spinal correction surgery for scoliosis at 12 years of age (Figure 1).
case_images: The change of bone turnover markers.. Notes: Serum TRACP-5b and urinary type I collagen amino-terminal telopeptide greatly decreased after the first administration. Serum bone-specific alkaline phosphatase and type I procollagen N-terminal propeptide decreased as well, while the whole-parathyroid hormone and 1-alpha, 25-dihydroxyvitamin D3 increased.. Abbreviations: BAP, bone-specific alkaline phosphatase; PINP, type I procollagen N-terminal propeptide; NTX, type I collagen amino-terminal telopeptide; TRACP-5b, tartrate-resistant acid phosphatase 5b.
case_images: tcrm-15-303Fig2.jpg
case_images: PMC6395054_01_tcrm-15-303Fig2.jpg
case_images: f2-tcrm-15-303
case_images: Serum tartrate-resistant acid phosphatase 5b (TRACP-5b) and urinary type I collagen amino-terminal telopeptide (NTX) greatly decreased after the first administration (Figure 2). Serum bone-specific alkaline phosphatase (BAP) and type I procollagen N-terminal propeptide (PINP) decreased as well, while the whole-parathyroid hormone (PTH) and 1-alpha, 25-dihydroxyvitamin D3 (1,25[OH]2D) increased (Figure 2).
case_images: The change of bone mineral density (BMD).. Notes: At 13 months of denosumab treatment, her total hip BMD T-score improved from -2.3 to -2.0, and the BMD increased by 4.5% for total hips at the end of our study. The change of femoral neck BMD was also similar.
case_images: tcrm-15-303Fig3.jpg
case_images: PMC6395054_01_tcrm-15-303Fig3.jpg
case_images: f3-tcrm-15-303
case_images: T-score (the number of standard deviations above (+) or below (-) mean peak young adult BMD) improved from -2.3 to -2.0, and the BMD increased by 4.5% for total hips at the end of our study (Figure 3). The change of femoral neck BMD was also similar (Figure 3). There were no fractures and falls during the treatment period.