case_images: PMC11282537_01
case_images: (a) Monomorphic tan-brown hyperpigmented papules over the trunk. (b) Indurated chalky white nodules over the knee.
case_images: 10.1177_2050313X241260500-fig1.jpg
case_images: PMC11282537_01_10.1177_2050313X241260500-fig1.jpg
case_images: fig1-2050313X241260500
case_images: A 9-year-old male presented with a 2.5-year history of progressive monomorphic 2-3 mm tan brown papules over the trunk (Figure 1(a)), upper and lower extremities as well as indurated chalky white nodules over the knees (Figure 1(b)), and right thumb which appeared over the same period.
case_images: (a) Histology of a 4-mm punch biopsy from a chest papule showing a focus of calcification in the upper dermis (10x magnification). (b) Characteristic features of a syringoma (epithelial cuboidal cells in comma-shaped nests and cords) are demonstrated in a subsequent biopsy from a different chest papule (10x magnification).
case_images: 10.1177_2050313X241260500-fig2.jpg
case_images: PMC11282537_01_10.1177_2050313X241260500-fig2.jpg
case_images: fig2-2050313X241260500
case_images: The papule showed focal dystrophic calcification with surrounding inflammation in the dermis (Figure 2(a)) and the nodule showed calcinosis cutis with possible perforation through the epidermis. Also, to clarify the diagnosis, a second biopsy was later obtained from a different chest papule and showed epithelial cuboidal cells in comma-shaped nests and cords typical of a syringoma (Figure 2(b)) and no evidence of concomitant calcification.