case_images: PMC10688200_01
case_images: Photomicrographs of the cervical biopsy. A - Tumor arranged in sheets and nest separated by thin fibrovascular septa. Tumor cells show moderate pleomorphism, hyperchromatic nuclei, round to ovoid nuclei, inconspicuous nuclei and scant to moderate cytoplasm (H&E 400x); B - On IHC, tumor cells are positive for PanCK (100x); C - NSE (100x); D - High Ki-67 proliferation index (100x).
case_images: autopsy-13-e2023452-g01.jpg
case_images: PMC10688200_01_autopsy-13-e2023452-g01.jpg
case_images: gf01
case_images: The tumor cells exhibited moderate nuclear pleomorphism, hyperchromatic round to ovoid nuclei, inconspicuous nucleoli, and scant cytoplasm (Figure 1A). Immunohistochemistry (IHC) yielded positive results for pancytokeratin (PanCK) (Figure 1B), Non-Specific Enolase (NSE) (Figure 1C), Synaptophysin, and high ki-67 proliferation index (Figure 1D) while negative for Chromogranin, p40, p63, and vimentin.
case_images: Photomicrograph of the Cervix. A - Tumor cells are arranged in infiltrative glands having vesicular chromatin and a moderate amount of cytoplasm (H&E 100x); B - CK7 staining in adenocarcinoma component (100x); C - Diffuse p16 staining (400x); D - Overlying squamous lining shows HSIL (H&E 400x).
case_images: autopsy-13-e2023452-g02.jpg
case_images: PMC10688200_01_autopsy-13-e2023452-g02.jpg
case_images: gf02
case_images: IHC showed positive staining for CK7 in the adenocarcinoma component (Figure 2A-B). Furthermore, the overlying squamous lining showed high-grade squamous intraepithelial lesion (HSIL) (Figure 2D). Diffuse p16 staining (Figure 2C) was observed in both the adenocarcinoma component and overlying dysplastic squamous epithelium.