case_images: PMC4291576_01
case_images: Dense collections of large cells with abundant eosinophilic cytoplasmic inclusions of fibrillar to crystalloid shape (A, B; HE 20x and 40x). Immunohistochemistry reveals their phagocytic lineage with strong expression of CD68 (C, 20x), whereas they are largely negative for GFAP (D, 20x).
case_images: clinneuropathol-34-004-01.jpg
case_images: PMC4291576_01_clinneuropathol-34-004-01.jpg
case_images: Figure1
case_images: Upon histology, large collections of pleomorphic cells with intracytoplasmic fibrillar and crystalloid inclusions (Figure 1A, B) were apparent. The immunoprofile with prominent reactivity for macrophage-associated CD68 (Figure 1C) and lack of glial fibrillary acidic protein (Figure 1D) suggested the diagnosis of CSH.