case_images: PMC11800022_01
case_images: Case Report 1. a: gross specimen of intestine showing two diffuse ulceroinfiltrative thickened lesions with intervening normal-appearing mucosa (rest of the mucosa shows superficial ulcers); b: ulcerative lesion infiltrated by medium sized lymphoid cells up to muscularis propria (HE, x100); c: diffuse immunopositivity for CD2 (x200); d: negative for CD20 (x200); e: abberant loss of CD4 (x200); f: immunopositivity for in-situ hybridisation of Eber (x200); g: aberrant loss of CD8 (x200); and h: immunopositivity for mRNA scopy of Eber (x200)
case_images: cureus-0017-00000077056-i01.jpg
case_images: PMC11800022_01_cureus-0017-00000077056-i01.jpg
case_images: FIG1
case_images: In between these two lesions, intervening mucosa appeared unremarkable (skip lesion) (Figure 1). EBV (Eber 1 and Eber 2). mRNA sequencing was also positive for amplified RNA sequencing of EBV (Figure 1). Extensive systemic and radiological examination did not reveal any nasal lesion, thereby excluding the possibility of a primary nasal origin. 
case_images: PMC11800022_02
case_images: Case Report 2. a: ulcerative lesion infiltrated by medium-sized lymphoid cells (HE, x100); b: lymphoid cells (x400); c: diffuse immunopositivity for CD3 (x200); d: negative for CD20 (x200); e: negative for CD4 (x200); f: positive for CD8 (x200)
case_images: cureus-0017-00000077056-i02.jpg
case_images: PMC11800022_02_cureus-0017-00000077056-i02.jpg
case_images: FIG2
case_images: On immunohistochemistry, the tumor cells are positive for CD3, CD8, and granzyme, whereas negative for CD20 and CD56 (Figure 2). 