case_images: PMC10202823_01
case_images: Interdigital lesions at the patient's first visit.
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case_images: Physical examination revealed several well-defined, reddish-brown, flat-topped, odorless plaques with smooth surfaces located in the interdigital web space between the second and third toes of the left foot (Figure 1).
case_images: The epidermis contained marked regular elongation of the rete ridges, parakeratosis, and acanthosis (original magnification 40x).
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case_images: Histopathology of the lesion revealed parakeratosis, abundant neutrophilic infiltration with acanthosis, and regular elongation of the rete ridges within the epidermis (Figures 2 and 3).
case_images: Evident neutrophilic infiltration in the epidermis layer and dermal inflammation with plasma cell predominance accompanied by swelling of endothelial cells of the small blood vessels (original magnification 200x).
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case_images: Histopathology of the lesion revealed parakeratosis, abundant neutrophilic infiltration with acanthosis, and regular elongation of the rete ridges within the epidermis (Figures 2 and 3). Dense infiltration of plasma cells was observed throughout the dermal layer (Figure 3).
case_images: Innumerable spirochetes within the epidermis and scattered spirochetes within the dermis detected by immunohistochemistry (original magnification 100x).
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case_images: Immunohistochemistry revealed numerous spirochetes within the epidermis (Figure 4).
case_images: Interdigital lesions completely resolved 1 month after treatment.
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case_images: One month after treatment, the skin lesion had entirely resolved, and only hyperpigmentation was observed (Figure 5).