case_images: PMC5987230_01
case_images: MRI showing a right temporal-parietal cystic mass that is T1 hypointense.
case_images: CRIS2018-1285729.001.jpg
case_images: PMC5987230_01_CRIS2018-1285729.001.jpg
case_images: fig1
case_images: This mass was hypointense on T1 (Figure 1) and hyperintense on T2 (Figure 2).
case_images: The cystic mass is hyperintense on T2-weighted MRI, with rim enhancement.
case_images: CRIS2018-1285729.002.jpg
case_images: PMC5987230_01_CRIS2018-1285729.002.jpg
case_images: fig2
case_images: This mass was hypointense on T1 (Figure 1) and hyperintense on T2 (Figure 2).
case_images: Intermediate power view of the tumor showing a cellular proliferation of large, epithelioid cells with abundant cytoplasm. Numerous multinucleated giants cells are present (H&E stain, 200x original magnification).
case_images: CRIS2018-1285729.003.jpg
case_images: PMC5987230_01_CRIS2018-1285729.003.jpg
case_images: fig3
case_images: Permanent histologic sections show a cellular neoplasm composed of large, epithelioid cells, with numerous multinucleated giant cells (Figure 3).
case_images: Significant variation in size and shapes (pleomorphism) is noted, with mitotic figures and regions of haemorrhage and necrosis (H&E stain, 400x original magnification).
case_images: CRIS2018-1285729.004.jpg
case_images: PMC5987230_01_CRIS2018-1285729.004.jpg
case_images: fig4
case_images: There is significant nuclear pleomorphism, with mitotic activity, haemorrhage, and necrosis (Figure 4).
case_images: Microvascular proliferation is evident in some regions of the tumor (H&E stain, 200x original magnification).
case_images: CRIS2018-1285729.005.jpg
case_images: PMC5987230_01_CRIS2018-1285729.005.jpg
case_images: fig5
case_images: Microvascular proliferation is seen (Figure 5), and an infiltrative interface is observed with adjacent brain parenchyma (Figure 6).
case_images: Intermediate power view of the tumor at interface with adjacent brain parenchyma, demonstrating an infiltrative border (H&E stain, 200x original magnification).
case_images: CRIS2018-1285729.006.jpg
case_images: PMC5987230_01_CRIS2018-1285729.006.jpg
case_images: fig6
case_images: Microvascular proliferation is seen (Figure 5), and an infiltrative interface is observed with adjacent brain parenchyma (Figure 6).
case_images: Diffuse immunoreactivity for GFAP confirms that the tumor is of glial-astrocytic origin (200x original magnification).
case_images: CRIS2018-1285729.007.jpg
case_images: PMC5987230_01_CRIS2018-1285729.007.jpg
case_images: fig7
case_images: Neoplastic cells show diffuse reactivity for the glial fibrillary acidic protein (GFAP) (Figure 7) and S-100 protein, confirming glial origin.
case_images: Immunohistochemistry for pancytokeratin shows no reactivity (positive control verified) (200x original magnification).
case_images: CRIS2018-1285729.008.jpg
case_images: PMC5987230_01_CRIS2018-1285729.008.jpg
case_images: fig8
case_images: There is no reactivity for pancytokeratin or AE1/AE3 (Figure 8).
case_images: The Ki-67 proliferative index is markedly elevated, indicating a high-grade, aggressive lesion (100x original magnification).
case_images: CRIS2018-1285729.009.jpg
case_images: PMC5987230_01_CRIS2018-1285729.009.jpg
case_images: fig9
case_images: The Ki-67 proliferative index is markedly elevated (Figure 9).