case_images: PMC2905718_01
case_images: Nodular lesions located on the upper lip.
case_images: DRP2010-569345.001.jpg
case_images: PMC2905718_01_DRP2010-569345.001.jpg
case_images: fig1
case_images: A 62-year-old Caucasian man presented a 2-month history of firm nodular lesions on the upper lip (Figure 1).
case_images: (a) Histopathology revealed a diffuse, monomorphous, nonepidermotropic infiltrate of large epithelioid cells throughout the entire dermis. (stain type:Hematoxylin and eosin; original magnification: x100). (b) Histopathology revealed a diffuse, monomorphous, nonepidermotropic infiltrate of large epithelioid cells throughout the entire dermis. (stain type:Hematoxylin and eosin; original magnification: x400).
case_images: DRP2010-569345.002.jpg
case_images: PMC2905718_01_DRP2010-569345.002.jpg
case_images: fig2
case_images: These cells were mixed with lymphocytes, plasma cells, and eosinophils (Figures 2(a) and 2(b)).
case_images: Immunohistochemical examination showed positivity for CD1a (a), CD68 (b), and S100 protein (c).
case_images: DRP2010-569345.003.jpg
case_images: PMC2905718_01_DRP2010-569345.003.jpg
case_images: fig3
case_images: Immunohistochemical examination revealed that the predominant cells coexpressed CD1a (Figure 3(a)), CD68 markers (Figure 3(b)), and S100 protein (Figure 3(c)).
case_images: Regression of the lesions after 7 months of treatment with thalidomide.
case_images: DRP2010-569345.004.jpg
case_images: PMC2905718_01_DRP2010-569345.004.jpg
case_images: fig4
case_images: Almost complete remission of the lesions was observed by the seventh month (Figure 4).