case_images: PMC9533139_01
case_images: Multiple dull red plaques were observed on the lower limbs.
case_images: fped-10-972224-g001.jpg
case_images: PMC9533139_01_fped-10-972224-g001.jpg
case_images: F1
case_images: On physical examination, multiple dull red plaques were observed on the lower limbs (Figure 1) and splenomegaly with spleen 3 cm below the left costal margin was also noted.
case_images: Bone marrow studies revealed hypercellular marrow with granulocytic hyperplasia. (A) Bone marrow smear (Wright's stain; original magnification, x400). (B) Bone marrow biospy (Hematoxylin-eosin stain; original magnification, x100).
case_images: fped-10-972224-g002.jpg
case_images: PMC9533139_01_fped-10-972224-g002.jpg
case_images: F2
case_images: Bone marrow studies revealed hypercellular marrow with granulocytic hyperplasia (Figure 2), negativity for BCR/ABL and a + 8 karyotype.
case_images: Genomic analysis revealed a CSF3R T618I somatic mutation and a CBL c.1096-1_1097delGGA frameshift somatic mutation. (A) CSF3R T618I somatic mutation. (B) CBL c.1096-1_1097delGGA frameshift somatic mutation.
case_images: fped-10-972224-g003.jpg
case_images: PMC9533139_01_fped-10-972224-g003.jpg
case_images: F3
case_images: Genomic analysis revealed a CSF3R T618I somatic mutation and a CBL c.1096-1_1097delGGA frameshift somatic mutation (Figure 3).
case_images: Skin biopsy showed immature blasts infiltrate. (A) Hematoxylin-eosin stain; original magnification, x100. (B) Hematoxylin-eosin stain; original magnification, x400.
case_images: fped-10-972224-g004.jpg
case_images: PMC9533139_01_fped-10-972224-g004.jpg
case_images: F4
case_images: Skin biopsy revealed a few blasts infiltrated in the dermis without dermal edema (Figure 4).