case_images: PMC9897911_01
case_images: Fluorescein angiography demonstrating hyperfluorescence in the early and late phases of the tumor on the iris from the 5 to 7 o'clock position and ciliary body (Zeiss). Part of the tumor is visible in the pupillary area posterior to the iris in the late-phase image.
case_images: CRIOPM2023-1508341.001.jpg
case_images: PMC9897911_01_CRIOPM2023-1508341.001.jpg
case_images: fig1
case_images: The fluorescein angiography demonstrated a hyperfluorescent tumor (Figure 1).
case_images: Anaplastic cells with mitosis and Ki-67-positive proliferative cells are shown. The cells are stained positive for S-100, CD56, and factor VIII (not shown in these figures). The rapid growth indicated by positive Ki-67, a proliferating marker, and the presence of anaplastic cells were the main reasons for the diagnosis of malignant medulloepithelioma. HE(S): hematoxylin-eosin (saffron).
case_images: CRIOPM2023-1508341.002.jpg
case_images: PMC9897911_01_CRIOPM2023-1508341.002.jpg
case_images: fig2
case_images: Cord-tubular structures without rosettes of the tumor epithelium, amorphous fibrilla of the tumor stroma, nuclear atypia, and mitosis were demonstrated histologically (Figure 2). The cells stained positive for S-100, Ki-67, CD56, and factor VIII and negative for PanMel, anti-M-actin, and cytokeratin (Figure 2).
case_images: PMC9897911_02
case_images: (a, b) Iris coloboma of the left eye following surgical treatment for medulloepithelioma (a) (Zeiss Clarius 700) and status following resection of the tumor (b) and laser-photocoagulated retina in the periphery (c) (Optos California) are shown. These images are taken 20 years following surgical removal of the malignant medulloepithelioma.
case_images: CRIOPM2023-1508341.003.jpg
case_images: PMC9897911_02_CRIOPM2023-1508341.003.jpg
case_images: fig3
case_images: An iris coloboma between 4 and 7 o'clock, thin sclera, an aphakic left eye with laser-photocoagulated peripheral retina were evident on examination (Figures 3(a) and 3(b)).