case_images: PMC4706661_01
case_images: Intraoral (a) and panoramic radiograph (b) showed a lesion around the upper left first and second molars
case_images: 13104_2015_1799_Fig1_HTML.jpg
case_images: PMC4706661_01_13104_2015_1799_Fig1_HTML.jpg
case_images: Fig1
case_images: Intraoral examination revealed a destructive ulcerative lesion around the upper left first and second molars, which showed mobility and poor dental conditions, including dental caries, gingival recession and bone loss (Fig. 1a). A panoramic radiograph revealed a radiolucent area in the periapical region of the upper left first molar, suggesting an osteolytic lesion (Fig. 1b).
case_images: Hematoxylin-eosin staining showed basophilic nuclei and eosinophilic cell plasma
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case_images: PMC4706661_01_13104_2015_1799_Fig2_HTML.jpg
case_images: Fig2
case_images: It showed a proliferation of cells resembling histiocytes with an occasional pale nucleus edentulous with a lobular, grain bean-like appearance (Fig. 2).
case_images: Immunohistochemical staining showed cells positive for S-100 protein (a) and CD1a protein (b)
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case_images: PMC4706661_01_13104_2015_1799_Fig3_HTML.jpg
case_images: Fig3
case_images: Microscopic findings and the presence of histiocytic cells led to the performance of an immunohistochemical staining panel using monoclonal antibodies for S-100 (Fig. 3a), CD1a (Fig. 3b), pan-cytokeratin, CD-68, melanoma marker (HMB45) and melanoma A protein.
case_images: Intraoral (a) view and panoramic radiograph (b) showed no bone disease (8 years later during follow-up)
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case_images: PMC4706661_01_13104_2015_1799_Fig4_HTML.jpg
case_images: Fig4
case_images: We have been following up with the patient for 8 years (2006-2014) without signs of disease recurrence (Fig. 4a and b).