case_images: PMC10927171_01
case_images: (a) Coronal T2-weighted image shows lobulated thickening of the optic chiasm with normal pituitary infundibulum and (b) axial fluid-attenuated inversion recovery shows the involvement of pre-chiasmatic optic nerves and optic tracts, (c) midsagittal contrast-enhanced T1-weighted spoiled gradient recalled echo demonstrates the avid lesion enhancement with involvement of the hypothalamus.
case_images: SNI-15-48-g001.jpg
case_images: PMC10927171_01_SNI-15-48-g001.jpg
case_images: F1
case_images: Radiologic findings were most suggestive of optic pathway glioma [Figure 1].
case_images: (a) Hematoxylin and eosin stained section (H&E @ x20), showing nests of slightly discohesive, large epithelioid cells with abundant cytoplasm and pleomorphic nuclei intermixed with benign lymphocytes, (b) immunohistochemistry reveals positive immunoreactivity against SALL4, OCT4, (c) immunohistochemistry reveals positive immunoreactivity against placental alkaline phosphatase (PLAP), and (d) negative immunohistochemistry for glial fibrillary acidic protein (GFAP), S100, AE1/AE3, CD45, and CD30.
case_images: SNI-15-48-g002.jpg
case_images: PMC10927171_01_SNI-15-48-g002.jpg
case_images: F2
case_images: The specimen exhibited histological patterns in keeping with germinoma [Figure 2].
case_images: (a) Coronal T2-weighted image shows interval reduction in the size of optic chiasm thickening (b) no residual enhancing lesion on midsagittal contrast-enhanced T1-weighted magnetic resonance image.
case_images: SNI-15-48-g003.jpg
case_images: PMC10927171_01_SNI-15-48-g003.jpg
case_images: F3
case_images: After completion of the radiotherapy sessions, the brain MRI revealed an interval reduction in the size of optic chiasm thickening without residual enhancing lesion [Figure 3].