case_images: PMC10939181_01
case_images: Gross view of the surgical specimen. A - Left mastectomy specimen showing a fungating ulcer on the lateral aspect (scale bar= 10 cm); B - Cut section shows a large fleshy dark brown to tan tumor occupying almost the entire breast (scale bar = 10 cm).
case_images: autopsy-14-e2024476-g01.jpg
case_images: PMC10939181_01_autopsy-14-e2024476-g01.jpg
case_images: gf01
case_images: On serial slicing of the breast, a large variegated tumor with solid cystic and hemorrhagic appearance measuring 17x17x8 cm was noted, involving the skin and almost the whole breast (Figure 1).
case_images: Photomicrographs of the tumor. A - Tumor arranged in diffuse sheets with overlying ulcerated skin (H&E,10x); B - Tumor cells with moderate eosinophilic cytoplasm, pleomorphic nuclei, coarse chromatin and prominent nucleoli (H&E,40x); C - Numerous osteoclast type giant cells intermingling with areas of osteoid (H&E,20x); D - Atypical mitotic figures (H&E, 20x).
case_images: autopsy-14-e2024476-g02.jpg
case_images: PMC10939181_01_autopsy-14-e2024476-g02.jpg
case_images: gf02
case_images: Lymphovascular emboli were also present (Figure 2).
case_images: Photomicrographs of the tumor. Immunohistochemical stains. A - positive Smooth Muscle Actin (20x); B - positive Desmin (20x); C - positive h-Caldesmon (20x); D - Ki67 -15% (20x).
case_images: autopsy-14-e2024476-g03.jpg
case_images: PMC10939181_01_autopsy-14-e2024476-g03.jpg
case_images: gf03
case_images: The Ki67 proliferation index was 15% (Figure 3) PanCK, EMA, p63, 34betaE12, CD34, CD31, Myogenin, CD10, CD117, S100, beta-HCG, ER, PR and HER2neu were negative.