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case_images: The histopathological findings and immunohistochemistry. (A) Prominent histiocytic infiltrate in a background of inflammatory cells (Hematoxylin & eosin, 100x). (B) Large histiocytes with engulfed intact lymphocyte showing emperipolesis (Hematoxylin & eosin, 400x). (C) The histiocytes showing positive for CD68. (D) The histiocytes showing positive for S100. (C, 200x; D, 200x).
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case_images: There were also some large histiocytes with engulfed intact lymphocytes, termed emperipolesis (Fig. 1A-1B). Immunohistochemistry demonstrated that the histiocytes were CD68 and S-100 positives, and CD1a negative (Fig. 1C-1D).
case_images: Clinical appearance of CRDD. (A) Clusters of red papules that coalesce into plaques on the mandible before treatment. (B) The lesion was flat and remarkably improved after three sessions of pulsed dye laser treatment at one-month intervals.
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case_images: The lesion was flat and remarkably improved. (Fig. 2A-2B) There were no apparent side effects and no recurrences during the 8 months of follow-up to date.