case_images: PMC11745220_01
case_images: (A) Brown-pink plaque on the left areola measuring 3 x 3 cm in size, with irregular borders, and flattened nipple. (B) Red arrow: scale, blue arrow: adherent fabric fibers, yellow arrow: superficial erosions, green ring: shiny white streaks, blue ring: irregular dotted vessel, black ring: pink, white structureless area. Dermlite DL4- x10 magnification - polarized mode. (C) Blue arrow: adherent fabric fibers, black arrow: superficial erosions, orange arrow: scale, green ring: segmental brown radial lines and brown-gray dots. Dermlite DL4- x10 magnification - polarized mode. (D) Blue arrow: scale, green arrow: adherent fabric fibers, yellow ring: dotted vessels, orange ring: segmental radial lines and brown-gray dots. Dermlite DL4- x10 magnification - polarized mode.
case_images: gr1.jpg
case_images: PMC11745220_01_gr1.jpg
case_images: fig0005
case_images: The plaque exhibited centrifugal growth, asymmetry, irregular borders, and scattered scaling (Fig. 1A). There were also brown-gray dots arranged in lines and dotted vessels in lines in some areas, adherent fabric fibers, and superficial erosions which are characteristic of Bowen's disease (Fig. 1B-D).
case_images: (A) Malignant epithelial cells dispersed as single or clustered cells in the epidermis (Hematoxylin & eosin, x200). (B) Membrane staining of malignant epithelial cells in the epidermis with C-ERB-B2 (x200). (C) Cytoplasmic staining of malignant epithelial cells with CK7 (x200).
case_images: gr2.jpg
case_images: PMC11745220_01_gr2.jpg
case_images: fig0010
case_images: Immunohistochemically, tumor cells were pan Cytokeratin (CK) and CK 7 positive, Estrogen Receptor (ER), and mucin negative (Fig. 2A-C).