case_images: PMC10722306_01
case_images: Neuro-ophthalmological findings 2 years after the onset of visual loss. (A, B) Bilateral optic atrophy was observed on dilated fundus examination. (C) Optical coherence tomography imaging showed significant thinning of the peripapillary retinal nerve fiber layer.
case_images: fneur-14-1292320-g0001.jpg
case_images: PMC10722306_01_fneur-14-1292320-g0001.jpg
case_images: F1
case_images: Prior investigations had concluded that the patient had severe bilateral optic atrophy with an almost total absence of retinal ganglion cells in the macula of both eyes (Figure 1).
case_images: T2-weighted contrast-enhanced brain MRI images taken from both patients. (A) Taken from patient 1 and showing bilateral enhancements of the posterior basal ganglia in particular the putamen. (B) Taken from patient 2 and showing hyperintensity of the optic tracts bilaterally. (C) Taken from patient 2 and showing hyperintense lesions in the subcortical layer of the cerebrum.
case_images: fneur-14-1292320-g0002.jpg
case_images: PMC10722306_02_fneur-14-1292320-g0002.jpg
case_images: F2
case_images: On repeated imaging, contrast material accumulation resolved, but signal enhancement along the right optic nerve and tracts became more marked (Figure 2B). There were also some small, non-specific, hyper-enhancing lesions present in subcortical, intracerebral locations (multiple in the corona radiata and one in the cerebellum), reported as small ischemic lesions, probably not contributing to the patient's symptoms (Figure 2C).
case_images: PMC10722306_02
case_images: T2-weighted contrast-enhanced brain MRI images taken from both patients. (A) Taken from patient 1 and showing bilateral enhancements of the posterior basal ganglia in particular the putamen. (B) Taken from patient 2 and showing hyperintensity of the optic tracts bilaterally. (C) Taken from patient 2 and showing hyperintense lesions in the subcortical layer of the cerebrum.
case_images: fneur-14-1292320-g0002.jpg
case_images: PMC10722306_02_fneur-14-1292320-g0002.jpg
case_images: F2
case_images: On repeated imaging, contrast material accumulation resolved, but signal enhancement along the right optic nerve and tracts became more marked (Figure 2B). There were also some small, non-specific, hyper-enhancing lesions present in subcortical, intracerebral locations (multiple in the corona radiata and one in the cerebellum), reported as small ischemic lesions, probably not contributing to the patient's symptoms (Figure 2C).
case_images: PMC10722306_03