case_images: PMC4680105_01
case_images: MRI of the neck revealing an anterior tongue mass.
case_images: CRIOT2015-242135.001.jpg
case_images: PMC4680105_01_CRIOT2015-242135.001.jpg
case_images: fig1
case_images: MRI of the neck revealed a mass involving the anterior two-thirds of the right tongue with irregular margins and ipsilateral right jugulodigastric lymphadenopathy (Figure 1).
case_images: H&E stain showing poorly differentiated adenocarcinoma.
case_images: CRIOT2015-242135.002.jpg
case_images: PMC4680105_01_CRIOT2015-242135.002.jpg
case_images: fig2
case_images: Punch biopsies of the tongue mass revealed poorly differentiated adenocarcinoma positive for cytokeratin 20, cytokeratin 5/6, P16, P63, CDx-2, Villin, and polyclonal CEA (Figures 2   -6).
case_images: IHC stain showing cytokeratin 20 (a and b) and CDx-2 (c) positivity, markers normally associated with gastrointestinal malignancies.
case_images: CRIOT2015-242135.003.jpg
case_images: PMC4680105_01_CRIOT2015-242135.003.jpg
case_images: fig3
case_images: Punch biopsies of the tongue mass revealed poorly differentiated adenocarcinoma positive for cytokeratin 20, cytokeratin 5/6, P16, P63, CDx-2, Villin, and polyclonal CEA (Figures 2   -6).
case_images: IHC stain positive for CK 5/6.
case_images: CRIOT2015-242135.004.jpg
case_images: PMC4680105_01_CRIOT2015-242135.004.jpg
case_images: fig4
case_images: Punch biopsies of the tongue mass revealed poorly differentiated adenocarcinoma positive for cytokeratin 20, cytokeratin 5/6, P16, P63, CDx-2, Villin, and polyclonal CEA (Figures 2   -6).
case_images: IHC stain positive for polyclonal CEA.
case_images: CRIOT2015-242135.005.jpg
case_images: PMC4680105_01_CRIOT2015-242135.005.jpg
case_images: fig5
case_images: Punch biopsies of the tongue mass revealed poorly differentiated adenocarcinoma positive for cytokeratin 20, cytokeratin 5/6, P16, P63, CDx-2, Villin, and polyclonal CEA (Figures 2   -6).
case_images: IHC stain positive for P63.
case_images: CRIOT2015-242135.006.jpg
case_images: PMC4680105_01_CRIOT2015-242135.006.jpg
case_images: fig6
case_images: Punch biopsies of the tongue mass revealed poorly differentiated adenocarcinoma positive for cytokeratin 20, cytokeratin 5/6, P16, P63, CDx-2, Villin, and polyclonal CEA (Figures 2   -6).
case_images: PET scan showing hypermetabolic activity in the tongue and neck.
case_images: CRIOT2015-242135.007.jpg
case_images: PMC4680105_01_CRIOT2015-242135.007.jpg
case_images: fig7
case_images: PET scan revealed hypermetabolic activity in the tongue and neck consistent with metastatic disease (Figures 7(a) and 7(b)).