case_images: PMC10598585_01
case_images: PMC10598585_02
case_images: Hematoxylin-eosin (HE) staining of liver tissue sections from Case 1 (age of 8 weeks: A,D) (age of 16 months: C,F) and Case 3 (age of 8 weeks: B,E). Immunohistochemical (IHC) staining of cytokeratin 7 (CK7), which is a specific marker for bile duct epithelial cells. Original magnification, x200.
case_images: fped-11-1275162-g001.jpg
case_images: PMC10598585_02_fped-11-1275162-g001.jpg
case_images: F1
case_images: In addition, much extramedullary hematopoiesis was observed (Figure 1). Cases 1 and2, ranging from 60 to 110 U/L. Case 1 underwent a second liver biopsy at the age of 16 months due to persistently abnormal liver function, and the results showed hydropic degeneration of hepatocytes along with only mild fibrosis and lymphocytic infiltration (Figure 1).