case_images: PMC10601845_01
case_images: a The fundus photo of the right posterior pole at presentation shows macular elevation, white-grayish discoloration of the macula, and diminished foveal reflex, with no bleeding, vascular alterations, or optic nerve head abnormalities. The macular edema appears with white concentric lines. b The fundus photo of the right posterior pole taken 3 weeks later shows resolved opacification of the retina, leaving mottling of retinal pigmented epithelium (RPE) in the affected area.
case_images: cop-2023-0014-0001-533886_F01.jpg
case_images: PMC10601845_01_cop-2023-0014-0001-533886_F01.jpg
case_images: F1
case_images: The fundus biomicroscopy of the right eye revealed thickening and white-grayish discoloration of the macula with subretinal fluid but without any bleeding or vascular alterations (see Fig. 1a). TAB, Iran Hormone, Iran) daily. Three weeks later, the patient's vision improved to 4/10, and the opacification of the retina was resolved, leaving mottling of retinal pigmented epithelium (RPE) in the affected area (see Fig. 1b).
case_images: a, b The horizontal macular OCT scans of the right eye taken at presentation show significant macular thickening, hyper-reflectivity of the inner retina (red arrow) with preserved architecture, giant intraretinal (asterisks) and subretinal (white arrow) pseudo-cystic changes along with multiple neurosensory retinal detachments (NSD) are indicated (arrowheads). c The horizontal macular OCT scan of the right eye taken 3 weeks later shows complete resolution of intra- and subretinal edema, with the retina appearing atrophic. The reflectivity of the retinal layers was subnormal, and the outer layers were slightly attenuated (yellow arrow). d The horizontal macular OCT scan of the right eye taken 6 months later shows surprising regeneration of the retinal outer layers, with slight residual attenuation of photoreceptors (pink arrow).
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case_images: PMC10601845_01_cop-2023-0014-0001-533886_F02.jpg
case_images: F2
case_images: Spectral domain optical coherence tomography (SD-OCT) (OCT Spectralis, Heidelberg Engineering, Germany) revealed a significant increase in the central macular thickness (985 microm), hyper-reflectivity of the inner layers of the retina with preserved architecture, giant cystic changes in the outer layers along with multiple neurosensory retinal detachments (NSD) (see Fig. 2a, b). Additionally, the ellipsoid zone was slightly attenuated (see Fig. 2c). During the 6-month follow-up, the patient's vision improved to 10/10, and the SD-OCT showed surprising regeneration of the retinal outer layers (see Fig. 2d).
case_images: a The fundus autofluorescence image of the right eye shows blocked autofluorescence corresponding to the edematous and opaque macula. b-d The fluorescein angiography of the right eye shows the macular hypofluorescence corresponding to the macular edema blockage, with no evidence of dye leakage in the retina, optic nerve head, vessel wall staining, or other vascular alterations.
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case_images: PMC10601845_01_cop-2023-0014-0001-533886_F03.jpg
case_images: F3
case_images: Fundus autofluorescence imaging indicated hypoautofluorescence corresponding to the edematous and opaque macula (see Fig. 3a). No evidence of dye leakage in the retina or optic nerve head, vessel wall staining, or other vascular alterations was found (see Fig. 3b-d).