case_images: PMC6815613_01
case_images: Baseline chest X-ray.
case_images: CRIHEM2019-2820954.001.jpg
case_images: PMC6815613_01_CRIHEM2019-2820954.001.jpg
case_images: fig1
case_images: The chest X-ray was normal (Figure 1).
case_images: (a, b) Peripheral blood smear revealing schistocytes and eosinophil (May-Gruunwald stain). (c) Partially degranulated eosinophils and schistocytes (May-Grunwald stain). (d, e) Bone marrow aspirate (May-Grunwald stain, 400x magnification). (f) Bone marrow trephine biopsy (hematoxylin-eosin stain, 200x magnification).
case_images: CRIHEM2019-2820954.002.jpg
case_images: PMC6815613_01_CRIHEM2019-2820954.002.jpg
case_images: fig2
case_images: Peripheral blood film showed schistocytosis (4%) with eosinophilia in partly degranulated forms (Figures 2(a)-2)(c). Erythroid and myeloid precursors showed progressive and orderly maturation (Figures 2(d) and 2(e)). Myeloid precursors were adequate with prominently increased eosinophilic lineage cells (Figure 2(f)).
case_images: Fluorescence in situ hybridization (FISH) analysis for FIP1L1/CHIC/PDGFRA (using Vysis/Abbott FISH probes) revealed FIP1L1/PDGFRA (4q12) rearrangement in 20.5% of the scored nuclei. ISCN: nuc ish (FIP1L1x2, CHICx1, PDGFRAx2) (FIP1L1 con PDGFRA) (41/200).
case_images: CRIHEM2019-2820954.003.jpg
case_images: PMC6815613_01_CRIHEM2019-2820954.003.jpg
case_images: fig3
case_images: FISH study done on the bone marrow aspirate for FIP1L1/PDGFRA (4q12) rearrangement detected abnormal signals in 26% of the 200 scored nuclei (Figure 3).
case_images: Clinical course, platelet count, hemoglobin, LDH, and eosinophil count of the patient. LDH, lactate dehydrogenase; PLEX, plasma exchange.
case_images: CRIHEM2019-2820954.004.jpg
case_images: PMC6815613_01_CRIHEM2019-2820954.004.jpg
case_images: fig4