case_images: PMC11380716_01
case_images: Comparison of two Richter transformations (RT) to diffuse large B-cell lymphoma (DLBCL) within the same patient. H&E-stained sections of a jejunal perforation showing increased medium to large atypical lymphoid cells (a) that were notably negative for CD5 (b) and positive for CD10 (c), found to be DLBCL RT to a clonally unrelated chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). A biopsy from a retroperitoneal mass in the same patient, 7 months later, also showed increased medium to large atypical lymphoid cells (d), but these cells are positive for CD5 (e) and negative for CD10 (f), found to be a clonally related DLBCL RT to the patient's CLL/SLL. ((a), (b), (d), (e) x40 objective; (c) and (f) x20 objective).
case_images: CRIHEM2024-7913296.001.jpg
case_images: PMC11380716_01_CRIHEM2024-7913296.001.jpg
case_images: fig1
case_images: The following day, after the lymph node biopsy, the patient underwent exploratory laparotomy with small bowel resection due to jejunal perforation resulting from the small bowel obstruction, which showed DLBCL with germinal center (GC) phenotype (Figures 1(a), 1(b), 1(c)). Approximately 7 months later, in March of 2022, a biopsy of the retroperitoneal mass-like conglomerate was again performed, and showed DLBCL with a non-GC phenotype (Figures 1(d), 1(e), and 1(f)).