case_images: PMC11758152_01
case_images: PMC11758152_02
case_images: Macroscopic and pathological finding of patient #2. (A) Macroscopic aspect of the explant with macronodular cirrhosis. (B) Pathological staining of liver explant. Left: Hematoxylin-ephloxine-safran coloration on liver tissue, with cirrhotic aspect (nodulisation of liver tissue). Right Masson Trichrome coloration on liver tissue, with mutilating fibrosis (green).
case_images: JMD2-66-e12463-g001.jpg
case_images: PMC11758152_02_JMD2-66-e12463-g001.jpg
case_images: jmd212463-fig-0001
case_images: PMC11758152_03
case_images: Macroscopic, imaging and pathological findings of patient #3. (A) Macroscopic aspect of the explant with voluminous liver adenoma, HCC nodules without cirrhosis. (B) Liver MRI. Left: T1 MRI with gadolinium enhancement. Right: T2 MRI. (C) Pathological exam on liver tissue, HES staining. Left: Heterogenous mosaic glycogen overload related with glycogenosis. Right: HCC with cytonuclear modification and architectural modification. (D) HES staining. (1) Liver adenoma with hemorrhagic transformation. (2) Normal liver tissue.
case_images: JMD2-66-e12463-g002.jpg
case_images: PMC11758152_03_JMD2-66-e12463-g002.jpg
case_images: jmd212463-fig-0002
case_images: In 2015, systematic screening by US scan and liver MRI showed a liver tumor (Figure 2) leading to right hepatectomy in 2016. PET scan was performed to exclude metastasis at that time. Pathological analysis (Figure 2) showed glycogen accumulation related with GSD and a moderately-differentiated HCC of 10 cm as well an unclassified adenoma of 11 cm, without any evidence of cirrhosis.