case_images: PMC4531975_01
case_images: Histologic findings of lymph node show large pleomorphic tumor cells with irregular nuclear profiles and abundant dense cytoplasm (H & E stain, x400).
case_images: kjim-12-1-84-16f1.jpg
case_images: PMC4531975_01_kjim-12-1-84-16f1.jpg
case_images: f1-kjim-12-1-84-16
case_images: A year prior to admission, he had had a history of enlargement of both cervical lymph nodes and postprandial epigastric pain, which was diagnosed to be early gastric cancer, Ki-1-positive anaplastic lymphoma, stage IIIB involving right submandibular lymph nodes, left cervical lymph nodes and hepatoduodenal lymph nodes (Fig. 1) without bone marrow involvement.
case_images: Photograpy shows multiple pin head sized erythematous papules on anterior chest wall (Arrow heads).
case_images: kjim-12-1-84-16f2.jpg
case_images: PMC4531975_01_kjim-12-1-84-16f2.jpg
case_images: f2-kjim-12-1-84-16
case_images: There were multiple small sized papulonodular eruptions on the anterior chest wall (Fig. 2).
case_images: Skin biopsy shows the dermis diffusely infiltrated with large pleomorphic tumor cells seen in lymph node (H & E stain, x200).
case_images: kjim-12-1-84-16f3.jpg
case_images: PMC4531975_01_kjim-12-1-84-16f3.jpg
case_images: f3-kjim-12-1-84-16
case_images: Light microscopic examination of skin specimen showed that the dermis was diffusely infiltrated with large pleomorphic tumor cells, which were strongly positive for Ki-1 immunohistochemical stain (Fig. 3, 4).
case_images: Tumor cells are strongly positive for Ki-1(immunohistochemical stain, x200).
case_images: kjim-12-1-84-16f4.jpg
case_images: PMC4531975_01_kjim-12-1-84-16f4.jpg
case_images: f4-kjim-12-1-84-16
case_images: Light microscopic examination of skin specimen showed that the dermis was diffusely infiltrated with large pleomorphic tumor cells, which were strongly positive for Ki-1 immunohistochemical stain (Fig. 3, 4).
case_images: Electromicroscopy shows that the tumor cell has convoluted nuclei with prominent nucleoli and sparse intracytoplasmic organelles.
case_images: kjim-12-1-84-16f5.jpg
case_images: PMC4531975_01_kjim-12-1-84-16f5.jpg
case_images: f5-kjim-12-1-84-16
case_images: Electromicroscopic examination revealed convoluted nuclei with prominent nuclei and sparse intracytoplasmic organelles (Fig. 5).