case_images: PMC8416249_01
case_images: Liver histology showed normal lobular architecture with few lymphocytes, monocytes and neutrophils infiltrating the portal areas were seen in (A) (H&E x 100). Extensive cholestasis of hepatocytes and the formation of bile embolism were better observed at a higher magnification in the centrilobular zone 3 on (B) (H&E x 400).
case_images: fmed-08-705489-g0001.jpg
case_images: PMC8416249_01_fmed-08-705489-g0001.jpg
case_images: F1
case_images: Immunohistochemical staining of hepatitis B surface antigen and hepatitis B core antigen, periodic acid-Schiff staining, copper staining, and iron staining were negative (Figure 1).
case_images: ATP8B1 c.1817T >C variant identified in the parents of our patient. We can deduce that his variant is potentially derived from his parents.
case_images: fmed-08-705489-g0002.jpg
case_images: PMC8416249_01_fmed-08-705489-g0002.jpg
case_images: F2
case_images: Aggregation Database (gnomAD), Human Gene Variant Database, and Clinvar of NCBI. A familial genetic testing by sanger sequencing showed heterozygosity in his parents' ATP8B1 genes (Figure 2).