case_images: PMC5112301_01
case_images: Lymphocytosis in the peripheral blood.
case_images: CRIONM2016-9037436.001.jpg
case_images: PMC5112301_01_CRIONM2016-9037436.001.jpg
case_images: fig1
case_images: Peripheral smear showed marked mature lymphocytosis, composed of medium sized cells with mature clumped chromatin, round nuclear contours, moderate cytoplasm, severe thrombocytopenia and hypochromic, and normocytic anemia (Figure 1).
case_images: Bone marrow aspirate depicts the marked increase in lymphocytes. They are uniformly small with mature chromatin, scant cytoplasm, and inconspicuous nucleoli.
case_images: CRIONM2016-9037436.002.jpg
case_images: PMC5112301_01_CRIONM2016-9037436.002.jpg
case_images: fig2
case_images: Megakaryocytes were increased in number and showed adequate morphology (Figures 2, 3, and 4).
case_images: Diffuse involvement of the bone marrow by CLL as shown on this core biopsy specimen.
case_images: CRIONM2016-9037436.003.jpg
case_images: PMC5112301_01_CRIONM2016-9037436.003.jpg
case_images: fig3
case_images: Megakaryocytes were increased in number and showed adequate morphology (Figures 2, 3, and 4).
case_images: High-power view of the biopsy depicting the markedly increased number of small, mature-appearing lymphoid cells.
case_images: CRIONM2016-9037436.004.jpg
case_images: PMC5112301_01_CRIONM2016-9037436.004.jpg
case_images: fig4
case_images: Megakaryocytes were increased in number and showed adequate morphology (Figures 2, 3, and 4).
case_images: Cytogenetics showing translocation (2;14)(p16;q32). Orange arrow.
case_images: CRIONM2016-9037436.005.jpg
case_images: PMC5112301_01_CRIONM2016-9037436.005.jpg
case_images: fig5
case_images: Conventional cytogenetics demonstrated an abnormal male karyotype: 47,XY,t(2;14)(p16;q32),+12[cp11]/46,XY[1], significant for the presence of the t(2;14) translocation (BCL11A-IGH) and trisomy 12 (Figure 5).