case_images: PMC10646746_01
case_images: H&Ex100: Partial replacement of the epithelium by atypical melanocytes with irregular hyperchromatic nuclei
case_images: ijp-18-488-g001.jpg
case_images: PMC10646746_01_ijp-18-488-g001.jpg
case_images: F1
case_images: On histological assessment, a nodular melanocytic neoplasm composed of variable-sized intraepithelial nests of melanocytes with occasionally pagetoid growth patterns as well as a surface epithelial ulcer was evident (Figure 1).
case_images: H&Ex200:Large atypical tumoral cells with nuclear pleomorphism, abundant cytoplasm, and prominent nucleoli
case_images: ijp-18-488-g002.jpg
case_images: PMC10646746_01_ijp-18-488-g002.jpg
case_images: F2
case_images: Assessment of the subepithelial components showed proliferation of uniform atypical melanocytes mostly with round epithelioid appearance and visible to prominent nucleoli (Figure 2).
case_images: H&Ex400: Nuclear pleomorphism with frequent mitoses in the deep component
case_images: ijp-18-488-g003.jpg
case_images: PMC10646746_01_ijp-18-488-g003.jpg
case_images: F3
case_images: Scattered mitosis (in about 3 per 10 HPF) was also present in superficial and deep components (Figure 3).
case_images: IHCx200: A strong positivity for Melan-A throughout the tumor
case_images: ijp-18-488-g004.jpg
case_images: PMC10646746_01_ijp-18-488-g004.jpg
case_images: F4
case_images: A in most of the tumoral cells with diffuse pattern in superficial and deep components (Full thickness) (Figure 4), HMB-45 positivity in tumor cells with patchy distribution in superficial and deep components (Figure 5), bcl2 with moderately to strongly positivity in most tumor cells in superficial and deep components, Cyclin D1 positivity in some tumor cells with patchy distribution in superficial and deep components. Ki67 labeling index was noted in about 10% of the tumoral cells in superficial and deep components (Figure 6). According to such immunolabeling, a final diagnosis of conjunctival melanoma was made.
case_images: IHCx200: a strong positivity for HMB45 throughout the tumor
case_images: ijp-18-488-g005.jpg
case_images: PMC10646746_01_ijp-18-488-g005.jpg
case_images: F5
case_images: A in most of the tumoral cells with diffuse pattern in superficial and deep components (Full thickness) (Figure 4), HMB-45 positivity in tumor cells with patchy distribution in superficial and deep components (Figure 5), bcl2 with moderately to strongly positivity in most tumor cells in superficial and deep components, Cyclin D1 positivity in some tumor cells with patchy distribution in superficial and deep components. Ki67 labeling index was noted in about 10% of the tumoral cells in superficial and deep components (Figure 6). According to such immunolabeling, a final diagnosis of conjunctival melanoma was made.
case_images: IHCx400: Ki67 stain shows a high proliferation index, located in superficial and deep aspects of the subepithelial component
case_images: ijp-18-488-g006.jpg
case_images: PMC10646746_01_ijp-18-488-g006.jpg
case_images: F6
case_images: A in most of the tumoral cells with diffuse pattern in superficial and deep components (Full thickness) (Figure 4), HMB-45 positivity in tumor cells with patchy distribution in superficial and deep components (Figure 5), bcl2 with moderately to strongly positivity in most tumor cells in superficial and deep components, Cyclin D1 positivity in some tumor cells with patchy distribution in superficial and deep components. Ki67 labeling index was noted in about 10% of the tumoral cells in superficial and deep components (Figure 6). According to such immunolabeling, a final diagnosis of conjunctival melanoma was made.