case_images: PMC10884723_01
case_images: Two photos side by side showing the eczematous itchy grouped scaly erythematous macules and patches predominantly on the left posterior medial thigh and left popliteal fossa, compared with the right posterior leg
case_images: cureus-0016-00000052816-i01.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i01.jpg
case_images: FIG1
case_images: Six months after beginning lorlatinib he presented with bilateral eczematous changes in the legs (Figure 1), which he treated with topical steroids and saw resolution of the right leg and left leg improvement.
case_images: Grouped draining pustules superficial erosions on the left posterior medial thigh and left knee L1-L3/zosteriform look and distribution
case_images: cureus-0016-00000052816-i02.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i02.jpg
case_images: FIG2
case_images: Nine days after the initiation of bevacizumab the patient began experiencing a transformation of the residual eczematous rash into weeping wet ulcers, some targetoid lesions on the left anterior thigh, anterior knee, left medial thigh, and crusted papules on the ankles medially and laterally (Figures 2-3).
case_images: Grouped draining pustules superficial erosions on the left posterior medial thigh and left knee L1-L3/zosteriform look and distribution
case_images: cureus-0016-00000052816-i03.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i03.jpg
case_images: FIG3
case_images: Nine days after the initiation of bevacizumab the patient began experiencing a transformation of the residual eczematous rash into weeping wet ulcers, some targetoid lesions on the left anterior thigh, anterior knee, left medial thigh, and crusted papules on the ankles medially and laterally (Figures 2-3).
case_images: Medial view left leg: initial improvement after acyclovir, erythematous plaques with superficial erosions in the same distribution (on the left posterior medial thigh and left knee L1-L3 distribution)
case_images: cureus-0016-00000052816-i04.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i04.jpg
case_images: FIG4
case_images: The patient was started on oral acyclovir 400mg three times daily for probable eczema herpeticum, with 50% improvement (Figure 4); however, new areas of erythema including the left scrotum and left medial thigh were appreciated and the patient was switched to valaciclovir 1g three time daily (Figures 5-7).
case_images: Left medial leg with erythema surrounding the erosive plaques in the same distribution seen in the days prior. This photograph was taken the day of the biopsy and two days after the patient worsened and was switched to valaciclovir
case_images: cureus-0016-00000052816-i05.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i05.jpg
case_images: FIG5
case_images: The patient was started on oral acyclovir 400mg three times daily for probable eczema herpeticum, with 50% improvement (Figure 4); however, new areas of erythema including the left scrotum and left medial thigh were appreciated and the patient was switched to valaciclovir 1g three time daily (Figures 5-7).
case_images: Close-up image of the left lateral leg with erythema surrounding the erosive plaques in the same distribution seen in the days prior. The photograph was taken the day of the biopsy and two days after the patient worsened and was switched to valaciclovir
case_images: cureus-0016-00000052816-i06.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i06.jpg
case_images: FIG6
case_images: The patient was started on oral acyclovir 400mg three times daily for probable eczema herpeticum, with 50% improvement (Figure 4); however, new areas of erythema including the left scrotum and left medial thigh were appreciated and the patient was switched to valaciclovir 1g three time daily (Figures 5-7).
case_images: Left lateral leg with erythema surrounding the erosive plaques in the same distribution seen in the days prior. The photograph was taken the day of the biopsy and two days after the patient worsened and was switched to valaciclovir
case_images: cureus-0016-00000052816-i07.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i07.jpg
case_images: FIG7
case_images: The patient was started on oral acyclovir 400mg three times daily for probable eczema herpeticum, with 50% improvement (Figure 4); however, new areas of erythema including the left scrotum and left medial thigh were appreciated and the patient was switched to valaciclovir 1g three time daily (Figures 5-7).
case_images: Lateral left leg: additional erythema beyond the plaques, patches, and erosions - developing cellulitic changes in the surrounding tissue
case_images: cureus-0016-00000052816-i08.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i08.jpg
case_images: FIG8
case_images: Two days following the biopsy the patient presented to the ER, due to the development of additional erythema beyond the plaques, patches, and erosions (Figures 8-13).
case_images: Posterior left leg: erythema beyond the plaques, patches, and erosions - developing cellulitic changes in the surrounding tissue
case_images: cureus-0016-00000052816-i09.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i09.jpg
case_images: FIG9
case_images: Two days following the biopsy the patient presented to the ER, due to the development of additional erythema beyond the plaques, patches, and erosions (Figures 8-13).
case_images: Medial left leg: additional erythema beyond the plaques, patches, and erosions - developing cellulitic changes in the surrounding tissue
case_images: cureus-0016-00000052816-i10.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i10.jpg
case_images: FIG10
case_images: Two days following the biopsy the patient presented to the ER, due to the development of additional erythema beyond the plaques, patches, and erosions (Figures 8-13).
case_images: Anterior legs: right superior knee new involvement of purpuric macules outside of L1-L3 dermatome became generalized
case_images: cureus-0016-00000052816-i11.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i11.jpg
case_images: FIG11
case_images: Two days following the biopsy the patient presented to the ER, due to the development of additional erythema beyond the plaques, patches, and erosions (Figures 8-13).
case_images: Posterior left leg: additional erythema beyond the plaques, patches, and erosions - developing cellulitic changes in the surrounding tissue
case_images: cureus-0016-00000052816-i12.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i12.jpg
case_images: FIG12
case_images: Two days following the biopsy the patient presented to the ER, due to the development of additional erythema beyond the plaques, patches, and erosions (Figures 8-13).
case_images: Added bilateral scrotal skin involvement erythema beyond plaques and patches
case_images: cureus-0016-00000052816-i13.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i13.jpg
case_images: FIG13
case_images: Two days following the biopsy the patient presented to the ER, due to the development of additional erythema beyond the plaques, patches, and erosions (Figures 8-13).
case_images: Side-by-side progression of the eruption
case_images: cureus-0016-00000052816-i14.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i14.jpg
case_images: FIG14
case_images: The progression of eruption is shown side by side (Figures 14-16).
case_images: Side-by-side progression of the eruption
case_images: cureus-0016-00000052816-i15.jpg
case_images: PMC10884723_01_cureus-0016-00000052816-i15.jpg
case_images: FIG15
case_images: The progression of eruption is shown side by side (Figures 14-16).