case_images: PMC3966260_01
case_images: PMC3966260_02
case_images: PMC3966260_03
case_images: Graphic summary of biochemical liver injury with administration of adalimumab in Subject 3. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).
case_images: CRIGM2014-956463.001.jpg
case_images: PMC3966260_03_CRIGM2014-956463.001.jpg
case_images: fig1
case_images: She was found to have elevated liver enzymes, with ALT 184 and AST 167 (Figure 1). After six weeks of drug discontinuation, liver enzymes normalized (Figure 1).
case_images: Liver biopsy showing portal inflammation in Subject 3 (hematoxylin and eosin stain, magnification x200).
case_images: CRIGM2014-956463.002.jpg
case_images: PMC3966260_03_CRIGM2014-956463.002.jpg
case_images: fig2
case_images: Also, histologically, occasional lymphocytic infiltrates of the bile duct epithelium were seen, focally resembling a florid ductal lesion (Figures 2 and 3).
case_images: Liver biopsy showing lymphocytic and plasma cell infiltrate in Subject 3 (hematoxylin and eosin stain, magnification x400).
case_images: CRIGM2014-956463.003.jpg
case_images: PMC3966260_03_CRIGM2014-956463.003.jpg
case_images: fig3
case_images: Also, histologically, occasional lymphocytic infiltrates of the bile duct epithelium were seen, focally resembling a florid ductal lesion (Figures 2 and 3).