case_images: PMC11770647_01
case_images: (H and E x 100) shows nested packets of moderately to markedly pleomorphic tumour cells (arrows) having predominantly stippled chromatin pattern resembling salt and pepper appearance consistent with neuroendocrine carcinoma.
case_images: nmj-65-1160-f1.jpg
case_images: PMC11770647_01_nmj-65-1160-f1.jpg
case_images: F1
case_images: Some of the cells have stippled chromatin patterns resembling salt and pepper appearance (Figure 1).
case_images: (H and E x 100) shows neuroendocrine tumour cells invading the serosal layer (short arrow) with associated tumour necrosis (long arrow)
case_images: nmj-65-1160-f2.jpg
case_images: PMC11770647_01_nmj-65-1160-f2.jpg
case_images: F2
case_images: These tumour cells have invaded the serosa and involved all six regional lymph nodes (with associated tumour necrosis) (Figure 2).
case_images: (Chromogranin Immunohistochemical stain x 100) shows strong 3+ immunopositivity (brown staining) in more than 80% of the tumour cells consistent with neuroendocrine carcinoma.
case_images: nmj-65-1160-f3.jpg
case_images: PMC11770647_01_nmj-65-1160-f3.jpg
case_images: F3
case_images: Immunohistochemistry showed positivity for chromogranin, epithelial membrane antigen, and anticytokeratin monoclonal antibodies 1 and 3 and was negative for CD 117 and CD 45 (Figure 3).