case_images: PMC11026626_01
case_images: Clinical image of the scalp lesion. A pinkish-hued, 2 cm-sized nodular lesion is observed, accompanied by localized alopecia at the left parietal area of the scalp.
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case_images: The lesion, measuring approximately 2 cm and displaying a pinkish hue, appeared as a nodular lesion accompanied by localized alopecia ( Figure 1 ).
case_images: Gross specimen and histopathological findings of the primary breast cancer and scalp lesion. (A) A gross specimen of the primary breast cancer diagnosed invasive lobular carcinoma with the area involved by the primary tumor annotated as a circle. (B) Tumor cells of the primary invasive lobular carcinoma arranged in slender linear strands one to two cells across, exhibiting the so-called Indian file appearance (arrow) (HE x 200). (C) On high-power photomicrograph, tumor cells are also arranged in single files, cords, and single cells (arrow) (HE x 400). (D) A gross specimen of the scalp lesion with the area involved by the metastasis annotated as a circle. (E) On low-power photomicrograph, tumor cells infiltrated the subcutaneous layer of the scalp without evidence of destruction to adjacent structures or skin appendages. (HE x 15) (F) Intact skin appendages were observed in high-power photomicrographs (arrowhead) (HE x 200) (G) Tumor cells of the scalp tumor showed a similar structural pattern to the primary breast cancer, exhibiting an Indian file appearance (arrow) (HE x 200).
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case_images: f2
case_images: Immunohistochemical staining showed positivity for cytokeratin 7 (CK7), estrogen receptor and partial positivity for gross cystic disease fluid protein 15 (GCDFP-15), a breast cancer-specific marker ( Figures 2 ,  3 ).
case_images: Immunohistochemical findings of the scalp lesion. (A) The immunohistochemical analysis revealed a positive staining for estrogen receptor, and (B) scattered partial positive staining for GCDFP-15.
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case_images: PMC11026626_01_fonc-14-1361333-g003.jpg
case_images: f3
case_images: Immunohistochemical staining showed positivity for cytokeratin 7 (CK7), estrogen receptor and partial positivity for gross cystic disease fluid protein 15 (GCDFP-15), a breast cancer-specific marker ( Figures 2 ,  3 ).
case_images: PET-CT findings of the patient. (A) A 1.5cm sized bulging lesion with soft tissue attenuation, involving subcutaneous layer of scalp along the left parietal area. (B) This lesion had a measured SUVmax value of 2, indicating a slight degree of hypermetabolism. (C) Maximum intensity projection images of PET-CT showed no evidence of other distant metastasis or recurrence.
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case_images: PMC11026626_01_fonc-14-1361333-g004.jpg
case_images: f4
case_images: No evidence of metastasis to other organs, excluding the scalp, or recurrence at the previously treated primary site was observed ( Figure 4 ).