case_images: PMC10517602_01
case_images: (a)/Low power, H&E x20: Skin tissue showing a thinned-out epidermis and dense infiltration of dermis by lymphoid cells (b)/High power, H&E x100: Dense infiltration with moderately atypical lymphoid cells.
case_images: 10.1177_20363613231204046-fig1.jpg
case_images: PMC10517602_01_10.1177_20363613231204046-fig1.jpg
case_images: fig1-20363613231204046
case_images: The epidermis was separated from the infiltrate by a grenz zone (Figure 1).
case_images: Immunohistochemical staining: (a)/CD8 highlighting the neoplastic cells (original magnifications x400); (b)/Neoplastic cells negative for CD20 (original magnification x40); (c)/Neoplastic cells negative for TdT (original magnification x20); (d)/Tumor cells focally positive for CD68 with a dot-like staining (original magnification x40); (e)/Low Ki-67 proliferation index (original magnification x40).
case_images: 10.1177_20363613231204046-fig2.jpg
case_images: PMC10517602_01_10.1177_20363613231204046-fig2.jpg
case_images: fig2-20363613231204046
case_images: Mitotic figures were sparse (1-2 mitoses/10 HPF). CD4, TdT, CD20, CD30, CD10, Bcl6, CD56, Granzyme B, and perforin. CD68 was focally positive with dot-like perinuclear staining. The Ki67 expression was low <5% (Figure 2). Chromogenic in situ hybridization was used to test for Epstein-Barr virus (EBV) using the EBER probe and revealed negative.