case_images: PMC10749294_01
case_images: Case history timeline for the nutritional management of a dog with hepatic enzymopathy suspected to be secondary to Cu-associated hepatitis. Each period indicates the biochemical findings, any diagnostics performed, and treatment and diet fed to the patient. The nutrition consult occurred at month 0. Transition between HMD1 and HMD2 occurred over 4 weeks following nutrition consultation *ALT reference range: 18-121 IU/L; **Cu tissue quantification to rule out familial Cu-associated hepatitis: normal <500 mug/g dry tissue.
case_images: fvets-10-1215447-g001.jpg
case_images: PMC10749294_01_fvets-10-1215447-g001.jpg
case_images: fig1
case_images: American Bulldog presented to the Clinical Nutrition Service at the Ontario Veterinary College's Health Sciences Center for a homemade diet (HMD) formulation for the nutritional management of hepatic enzymopathy and suspected Cu-associated hepatitis. A case timeline is provided in Figure 1.
case_images: (A) Serum ALT concentrations in a 4-year-old, female spayed American Bulldog with hepatic enzymopathy. Nutrition consult occurred at month 0. The patient was eating diets with different copper content. At the time of nutrition consult, the patient was eating an unbalanced diet with copper content below the minimum recommended by NRC, this coincides with the ALT values falling within normal reference ranges. (B) This figure exemplifies the dietary Cu content fed to a 4-year-old, female spayed American Bulldog with hepatic enzymopathy compared vs. the minimum requirements by the NRC, AAFCO, and FEDIAF at different time points. The red colored bar indicates when the dietary Cu content was below the minimum recommended by NRC. Nutrition consult occurred at month 0.
case_images: fvets-10-1215447-g002.jpg
case_images: PMC10749294_01_fvets-10-1215447-g002.jpg
case_images: fig2
case_images: Medical history obtained from the referring internal medicine specialist revealed a 3-month history of gradual increase in serum ALT activity (Figure 2).