case_images: PMC11338777_01
case_images: (A) Preoperative image of 2 year-old pygmy goat with a giant cell tumor of bone involving the rostral mandible. (B) Frontomandibular and (C) lateral radiographs of the rostral mandible of a goat with a giant cell tumor of bone. Displayed is an expansile, multi-cavitated mass mostly within the mandibular cortex, with primarily signs of lysis involving the mandibular symphysis. The left mandibular incisor teeth are displaced and partially covered by protruding soft tissue.
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case_images: fig1
case_images: The mass was mostly covered by partially ulcerated oral mucosa and firmly adhered to the mandible (Figure 1A). Marked signs of alveolar bone resorption with lateral displacement of the left mandibular incisor teeth which were partially covered by protruding soft tissue, was present (Figures 1B,C).
case_images: Lateral (A) and oblique (B) postoperative radiographs after extensive rostral mandibulectomy without internal fixation of the mandibles in a goat to achieve en-bloc resection of a giant cell tumor of bone. A slightly irregular bone structure is visible at the level of the right mandibular stump likely caused by the repeated attempts to achieve hemostasis during surgery.
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case_images: fig2
case_images: Radiographs 10 days post-surgery were unremarkable except for a slightly irregular bone structure of the right mandibular stump, likely caused by the repeated attempts to achieve hemostasis during surgery (Figures 2A,B).
case_images: Gross, histologic and electron microscopic images of a giant cell tumor of bone in a goat. (A) Gross image showing the neoplastic mass within the bone marrow of the mandible associated with osteolysis and expansion of the bone cavity. The tumor breaks through the bone lingually and protrudes into the oral cavity. (B,C) Histological images of the tumor showing the characteristic osteoclast-like giant cells and fibroblast-like spindle cells. (D) Electron microscopic image of a multinucleated giant cell (upper part of the image) and spindle cells (lower part of the image).
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case_images: fig3
case_images: Grossly, the bone cavity was focally extended by an approximately 4 cm in diameter mass (Figure 3). Consistent with the histologic findings, the ultrastructural investigation of the tumor showed predominantly reactive osteoclast-like multinucleated giant cells as well as proliferative mononuclear stromal cells (Figure 3).
case_images: Alignment of the published mRNA sequence of a Capra hircus H3.3-like histone (accession number XM_018048046) with our sequence (referred to as Sample 1) and electropherogram of our sequence. The arrow indicates the transversion site.
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case_images: fig4
case_images: Figure 4 shows the alignment of the published mRNA sequence of a Capra hircus H3.3-like histone (accession number XM_018048046) with our sequence.
case_images: (A) Image of the goat 3 months after surgery. At this time, the goat was eating normally, with stability of both mandibles and a firm, prominent bony callus at the surgical site. Cosmetic appearance was deemed satisfactory by the owners. (B,C) Frontomandibular radiographic views 3 and 4 months after extensive rostral mandibulectomy without internal fixation of the mandibles. Advanced fusion of both mandibles with moderately irregular bony callus is visible after 3 months (B) which appears slightly less irregular with decreased callus size after 4 months (C).
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case_images: fig5
case_images: At the 3-month re-check, the goat was eating normally, with stability of both mandibles and a firm, prominent bony callus at the surgical site (Figure 5A). Radiographs showed advanced fusion of both mandibles with moderately irregular bone structure (Figure 5B). A second re-check examination 1 month later revealed that the callus size had decreased, and bone structure appeared more regular (Figure 5C).