case_images: PMC11088233_01
case_images: The changes of biomarkers between newly-diagnosed and relapsed biopsies. (A-D) Negative expression of ER, PR, and HER-2. (E-H) Positive expression of ER, PR, and HER-2.
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case_images: Immunohistochemical examinations showed ER (-), PR (-), HER2 (-), and Ki-67 (80% +), indicating triple-negative type breast cancer ( Figure 1 ). FISH detection ( Figure 1 ). Finally, the patient was diagnosed with Luminal B type (HER2 positive), i.e.
case_images: The CT changes of different metastatic lesions from liver (A-D).
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case_images: Abdominal CT indicated multiple metastatic tumors of the liver ( Figure 2 ). In December 2023, the latest efficacy was evaluated, and the hepatic metastatic lesions almost disappeared, indicating nCR ( Figure 2 ).
case_images: Magnetic resonance imaging (MRI) examinations of right frontal lobe metastasis (red arrow). (A, D) The presence of solid brain metastasis (diameter of 1 cm). (B, E) and (C, G) The disappearance of brain metastasis.
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case_images: Figure 3 ). For liver metastases, the clinical efficacy showed partial remission (PR).
case_images: Detailed time course of the patient's clinical course and therapeutic regimens.
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case_images: She has achieved progression-free survival (PFS) of over 12 months and the overall survival of 69 months up to now ( Figure 4 ).