case_images: PMC10711094_01
case_images: (A-D) shows the preoperative image of the patient: CT of the brain (A) revealed an irregular jumble density mass with a well-defined boundary of the right thalamus. The right lateral and third ventricles were compressed and deformed, and the center line structure shifted to the left. MRI results of the brain (B-D) revealed irregular mixed signals and a remarkably enhancing mass of the right thalamus with multiple cystic lesions and a liquid-liquid plane. (E-H) shows the image of the patient 12 years after the operation: MRI results of the brain (E, F) revealed some abnormal signals of the medial area of the right temporal lobe, right cerebral foot, cisterna annulus, CPA area, and pontine arm. MRI results of the brain (G) revealed a new abnormal enhancing mass of the spinal canal (C1-C2 level). MRI results of the cervical vertebra (H) revealed multiple spinal cord spread.
case_images: fonc-13-1272831-g001.jpg
case_images: PMC10711094_01_fonc-13-1272831-g001.jpg
case_images: f1
case_images: Postoperative pathological showed the mass as a DIG/DIA ( Figure 1 ).
case_images: HE staining (A): The tumor was mainly composed of fibroblast-like spindle cells with radial-wheel, bundle, or vortex arrangement and cytoplasmic eosinophilic pleomorphic neoplastic astrocytes with bundle or nest formation distribution. Pathological diagnosis was DIG/DIA. HE staining (B): The tumor cells showed diffuse growth, high density of tumor cells, and prominent atypia. It is easy to see mitotic images, nuclear fragmentation, and local background microcystins. Intravascular glomus hyperplasia was also observed. The pathological diagnosis was glioblastoma (WHO Grade 4).
case_images: fonc-13-1272831-g002.jpg
case_images: PMC10711094_01_fonc-13-1272831-g002.jpg
case_images: f2
case_images: The pathological diagnosis was glioblastoma (WHO Grade 4,  Figure 2 ).