case_images: PMC10630002_01
case_images: The nodule was located next to the blood vessel and bronchus. The blood vessel and bronchus ran naturally without any involvement (a). There was a small cavity in the nodule, and the inner wall was smooth (b). It was slightly strengthened after enhancement, and the adjacent blood vessel wall was smooth (c). The nodule was lobulated with short burrs in the sagittal plane (d).
case_images: CRIPA2023-5566499.001.jpg
case_images: PMC10630002_01_CRIPA2023-5566499.001.jpg
case_images: fig1
case_images: The blood vessel and bronchus ran naturally without any involvement (Figure 1(a)). There was a small cavity in the nodule, and the inner wall was smooth (Figure 1(b)). The nodule was slightly strengthened when enhanced by the scan (Figure 1(c)). There were shallow lobes and burrs on the edge (Figure 1(d)).
case_images: HE staining. Overall view of tumor (a) (40x). Double-layer cell structure, the cavity surface was pure columnar mucinous cells (b) (100x). There was a small amount of papillary (c) (black arrow, 40x), with abundant intracellular and extracellular mucus (c) (black star). Continuous basal cells (d) (black arrow, 200x) can be seen. Basal cells in some areas were not obvious (e) (200x, black arrow). There were abundant stromal cells in some sections (f) (200x, black arrow).
case_images: CRIPA2023-5566499.002.jpg
case_images: PMC10630002_01_CRIPA2023-5566499.002.jpg
case_images: fig2
case_images: Some gland cavities expanded, and mucus was accumulated in the cavities (Figure 2(a)). The cavities were lined purely by mucinous luminal cells, and a continuous layer of basal cells was under the mucinous luminal cells (Figure 2(b)). There was abundant intracellular and extracellular mucus (Figure 2(c)). The basal cell size was relatively uniform, and no mitosis or necrosis was found (Figure 2(d)). Basal cells in some areas were not obvious (Figure 2(e)). There were abundant interstitial cells in some sections (Figure 2(f)).
case_images: Immunohistochemistry. Both mucinous luminal cells and basal cells were positive for TTF1 (a) (200x). Basal cells were positive for p40 (b) (200x). Focal mucinous luminal cells were positive for NapsinA (c) (200x). Mucinous luminal cells were positive for EGFR (d) (200x).
case_images: CRIPA2023-5566499.003.jpg
case_images: PMC10630002_01_CRIPA2023-5566499.003.jpg
case_images: fig3
case_images: P40, P63, CK5/6, and TTF-1 in continuous basal cells showed positivity (Figures 3(a) and 3(b)). CK7, Tyr1068 EGFR, and MUC1 in mucinous luminal cells all showed positivity, while NapsinA was focally positive (Figures 3(c) and 3(d)).