case_images: PMC11066203_01
case_images: Timeline in hospital days after admission of clinical characteristics, prospective (prosp.) and retrospective (retr.) diagnostic testing. White bars represent negative diagnostic results, light grey bars represent borderline values and dark grey bars represent positive results. (1,3)-beta-D-glucan (BDG) cutoff values for CSF were chosen as set for BDG testing in serum. Each BDG test was performed in parallel with both Fungitell and Wako FUJIFILM approach. BDG, (1,3)-beta-D-glucan; CUL, culture; EBV, Epstein-Barr virus PCR; EUB, bacterial PCR; HCV, hepatitis C virus PCR; HIV, human immunodeficiency virus PCR; JCV, JC virus (human polyomavirus 2) PCR; LP, lumbar puncture; M/E, BIOFIRE FILMARRAY Meningitis/Encephalitis (ME) panel; NGS, next-generation sequencing; P, CSF puncture; PAN, pan-fungal PCR; TBC, tuberculosis culture and PCR; TBE, tick-borne encephalitis; TOX, toxoplasmosis PCR; VD, ventricular drainage. For details on medical treatment, refer to the Supplementary File.
case_images: fcimb-14-1322847-g001.jpg
case_images: PMC11066203_01_fcimb-14-1322847-g001.jpg
case_images: f1
case_images: Analysis of CSF revealed mixed pleocytosis, low glucose, elevated protein and lactate levels, but extensive microbiological testing was unrevealing (Figure 1). Progressive hydrocephalus and clinical deterioration prompted the insertion of two external ventricular drainages on day 194, allowing additional amphotericin administration directly into the ventricles (see Supplementary Figure 1).