case_images: PMC2639602_01
case_images: (H&E). Langerhans cell histiocytosis of the bone. Collections of eosinophils and mononuclear Langerhans cells. x10.
case_images: 1752-1947-3-35-1.jpg
case_images: PMC2639602_01_1752-1947-3-35-1.jpg
case_images: F1
case_images: Langerhans cells (Figure 1). Langerhans cells showed somewhat glassy pink cytoplasms, indistinct cell borders and longitudinal coffee-bean grooves in their nuclei with undulating or indented nuclear membranes.
case_images: Langerhans cell histiocytosis of the bone. Immunohistochemical positive reaction with S100 in bone lesion x10.
case_images: 1752-1947-3-35-2.jpg
case_images: PMC2639602_01_1752-1947-3-35-2.jpg
case_images: F2
case_images: The immunohistochemical staining showed positive reactivity for S100 and CD1a and negative reactivity for CD15 and CD30 in large cells with folded nuclei (Figure 2).