case_images: PMC11766264_01
case_images: Ultrasound aspect of the large nodule in the left thyroid lobe. The nodule exhibits a non-homogeneous, hypoechogenic structure with poorly defined margins and internal calcifications (arrow).
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case_images: A negative Doppler signal was described at the center of the nodule, while its periphery showed partial vascularization (Figure 1).
case_images: Cervical MRI with gadolinium contrast showing a gadolinium-avid tumor (arrow) located posteriorly to the left thyroid lobe.
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case_images: This tumor exerted pressure on adjacent structures, including the esophagus and trachea (Figure 2).
case_images: Macroscopic aspect of the tumor: a 1.8 x 1.6 x 1.3 cm specimen characterized by a non-uniform aspect, creamy coffee color, and brown stripes.
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case_images: The tumor (Figure 3) was distorted and contained in the left lobectomy specimen, situated in the lower external third, with dimensions of 1.8 x 1.6 x 1.3 cm.
case_images: Mesenchymal proliferation with nodular growth and infiltrative edges (hematoxylin and eosin stain; 40x magnification).
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case_images: Additionally, a tumoral mesenchymal proliferation (Figure 4) was observed.
case_images: Positive immunohistochemistry for vimentin (40x magnification).
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case_images: Immunohistochemical studies demonstrated that the cells showed zonal expression for smooth muscle actin (BD Biosciences (Franklin Lakes, NJ, USA)), desmin (BD Biosciences, clone D33, 610711), and vimentin (BD Biosciences, clone V9, 550513) (Figure 5), and stained nuclear and cytoplasmic with beta-catenin (BD Biosciences, clone 14, 610153) (Figure 6), but were negative for pan-cytokeratin, CD34 and S-100.
case_images: Positive immunochemistry for beta-catenin with a strong nuclear pattern (40x magnification).
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case_images: Immunohistochemical studies demonstrated that the cells showed zonal expression for smooth muscle actin (BD Biosciences (Franklin Lakes, NJ, USA)), desmin (BD Biosciences, clone D33, 610711), and vimentin (BD Biosciences, clone V9, 550513) (Figure 5), and stained nuclear and cytoplasmic with beta-catenin (BD Biosciences, clone 14, 610153) (Figure 6), but were negative for pan-cytokeratin, CD34 and S-100.
case_images: The mast cells positive for the C-Kit dispersed along blood vessels (40x magnification).
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case_images: Mast cells are positive for C-Kit and were distributed along the blood vessels, while the inflammatory infiltration was located between the lesion and the surrounding adjacent soft tissues (Figure 7).