case_images: PMC9909717_01
case_images: Cases of NS treated with ixekizumab. a Patient 1 after 6 weeks of treatment with ixekizumab. b Improved skin condition after 1 year of treatment. c Widespread polycyclic, double-edged scaling and erythematous plaques before treatment with ixekizumab in patient 2. d Substantial improvement after 2 years and 4 months of treatment.
case_images: drm-0239-0072-g01.jpg
case_images: PMC9909717_03_drm-0239-0072-g01.jpg
case_images: F1
case_images: PMC9909717_02
case_images: Cases of Netherton treated with anakinra. a Lower back of patient 1 before treatment (widespread polycyclic, double-edged scaling and erythematous plaques) with anakinra and b improvement of the skin condition after 6 weeks of treatment. Patient 4 before (c) and after (d) 3 months of anakinra treatment. Patient 5 before (e) and after (f) 2.5 months of anakinra treatment.
case_images: drm-0239-0072-g02.jpg
case_images: PMC9909717_03_drm-0239-0072-g02.jpg
case_images: F2
case_images: The symptoms of patient 4 were characterized by erythroderma and ichthyosis linearis circumflexa, most prominently on the upper back and face (VIIS 14) and slightly improved within 1 month (VIIS 13) mainly with less erythroderma and scaling on the face (Fig. 2c, d). In addition to less scaling and erythroderma, most prominent on the upper legs, she experienced less painful calves and more energy (Fig. 2e, f).
case_images: PMC9909717_03
case_images: Cases of NS treated with ixekizumab. a Patient 1 after 6 weeks of treatment with ixekizumab. b Improved skin condition after 1 year of treatment. c Widespread polycyclic, double-edged scaling and erythematous plaques before treatment with ixekizumab in patient 2. d Substantial improvement after 2 years and 4 months of treatment.
case_images: drm-0239-0072-g01.jpg
case_images: PMC9909717_03_drm-0239-0072-g01.jpg
case_images: F1
case_images: Cases of Netherton treated with anakinra. a Lower back of patient 1 before treatment (widespread polycyclic, double-edged scaling and erythematous plaques) with anakinra and b improvement of the skin condition after 6 weeks of treatment. Patient 4 before (c) and after (d) 3 months of anakinra treatment. Patient 5 before (e) and after (f) 2.5 months of anakinra treatment.
case_images: drm-0239-0072-g02.jpg
case_images: PMC9909717_03_drm-0239-0072-g02.jpg
case_images: F2
case_images: The symptoms of patient 4 were characterized by erythroderma and ichthyosis linearis circumflexa, most prominently on the upper back and face (VIIS 14) and slightly improved within 1 month (VIIS 13) mainly with less erythroderma and scaling on the face (Fig. 2c, d). In addition to less scaling and erythroderma, most prominent on the upper legs, she experienced less painful calves and more energy (Fig. 2e, f).