case_images: PMC10631778_01
case_images: Photomicrographs of stained sections from the brain biopsy sample. a H and E, x20. Reveals lymphocytic infiltration into the brain parenchyma. b CD20 stain, x20. Positive stain suggests the presence of B lymphocytes in tissue sample. c, d Kappa and lambda chromogenic in situ hybridization (CISH) stain, x20. Demonstrates clonality of B-cell population in the biopsy tissue.
case_images: cro-2023-0016-0001-534528_F01.jpg
case_images: PMC10631778_01_cro-2023-0016-0001-534528_F01.jpg
case_images: F1
case_images: The final pathology was consistent with lymphoplasmacytic lymphoma, confirmed with a positive MYD88 L265P mutation by polymerase chain reaction, and he was diagnosed with BNS (Fig. 1).
case_images: a, b Magnetic resonance imaging (MRI) of the cervical spine at initial diagnosis (a) and 2 weeks after (b) ibrutinib therapy. c, d Brain MRI at initial diagnosis (c) and 2 weeks after (d) ibrutinib therapy. Light blue arrows indicate the cervico-medullary junction mass. Yellow arrows indicate lesions in the bilateral cerebral hemispheres.
case_images: cro-2023-0016-0001-534528_F02.jpg
case_images: PMC10631778_01_cro-2023-0016-0001-534528_F02.jpg
case_images: F2
case_images: A brain MRI collected at that time showed significant interval shrinkage of the cervico-medullary junction mass and bilateral CNS lesions (Fig. 2).