case_images: PMC3556408_01
case_images: Multiple-grouped flaccid pustules varying in size from 2 to 10 mm that tended to coalesce to form annular, circinate, or serpiginous pattern and superficial crusts on the normal or mildly erythematous skin, of the face, trunk, and extremities.
case_images: CRIM.DM2013-424797.001.jpg
case_images: PMC3556408_01_CRIM.DM2013-424797.001.jpg
case_images: fig1
case_images: The dermatologic examination revealed multiple-grouped flaccid pustules varying in size from 2 to 10 mm that tended to coalesce to form annular, circinate, or serpiginous pattern and superficial crusts on the normal or mildly erythematous skin, of the face, trunk, and extremities (Figure 1).
case_images: Histological examination: subcorneal pustule immediately below the stratum corneum containing mainly neutrophils; the underlying epidermis show slight intercellular edema (HE x20).
case_images: CRIM.DM2013-424797.002.jpg
case_images: PMC3556408_01_CRIM.DM2013-424797.002.jpg
case_images: fig2
case_images: Histopathology demonstrated a subcorneal vesiculo-bullous dermatitis (Figure 2); the pustule is located immediately below the stratum corneum and contains mainly neutrophils with few eosinophils.
case_images: Immunofluorescence. IgA-FITC 40X. The figure shows no antibody reactivity in epithelial cells and dermal-epithelial junction (basement membrane).
case_images: CRIM.DM2013-424797.003.jpg
case_images: PMC3556408_01_CRIM.DM2013-424797.003.jpg
case_images: fig3
case_images: Direct immunofluorescence studies are negative for immunoglobulin A (IgA) intercellular accumulation (Figure 3).
case_images: Followup at 2 weeks. The patient was treated with Dapsone. The cutaneous lesions were almost completely healed.
case_images: CRIM.DM2013-424797.004.jpg
case_images: PMC3556408_01_CRIM.DM2013-424797.004.jpg
case_images: fig4
case_images: The cutaneous lesions were almost completely healed at the first followup, within 2 weeks (Figure 4).