case_images: PMC10871737_01
case_images: a Hematoxylin-eosin stain of a renal tissue section. Moderate-grade parenchymal damage of the cortex with moderate nephrosclerosis and minor arteriolohyalinosis, as well as tubulointerstitial inflammation with focal acute tubule damage, are present. b Vacuolated cytoplasm (marked with arrows) is noticed in the podocytes in periodic acid-Schiff-stained sections. c Electron microscopy displays an exemplary podocyte with numerous lamellar bodies, the so-called zebra bodies.
case_images: cnd-2024-0014-0001-536448_F01.jpg
case_images: PMC10871737_01_cnd-2024-0014-0001-536448_F01.jpg
case_images: F1
case_images: SLE activity in the kidney requiring subsequent intensification of immunosuppression. Sequential renal biopsy performed in July 2022 revealed moderate chronic parenchymal damage of the cortex with moderate nephrosclerosis, focal segmental and global glomerulosclerosis (in 5 of 11 glomeruli), and minor arteriolohyalinosis, as well as tubulointerstitial inflammation with focal acute tubular damage (Fig. 1a). In addition, mild vacuolization of the cytoplasm was noted (Fig. 1b). Fig. 1). Electron microscopy did not reveal any evidence of basement membrane deposits but podocyte foot process effacement and numerous lamellar bodies predominantly localized in podocytes (Fig. 1c), which were not described in the previous biopsy from 2020.