case_images: PMC4275024_01
case_images: Rectal endoscopy.. Ulceration in the lining of the rectum corresponding to metastases from the ovarian primary.
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case_images: PMC4275024_01_f1000research-3-6353-g0000.jpg
case_images: f1A
case_images: The patient underwent sigmoidoscopy that revealed extended ulcerations of the lining of the rectum ( Figure 1A). The breast and rectal biopsies showed a positive staining of PAX8 by immunohistochemistry ( Figure 1B).
case_images: PMC4275024_02
case_images: Biopsy of the breast metastasis.. 20x magnification. Positive staining PAX8 on immunohistochemistry: Nuclear staining dark brown in tumor cells of ovarian origin within the mammary stroma stained blue.
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case_images: PMC4275024_02_f1000research-3-6353-g0001.jpg
case_images: f1B
case_images: Moreover, it showed a Fludeoxyglucose (FDG) uptake at PET-CT in the right breast and the ipsilateral axillary lymph node suggesting a primary breast cancer ( Figure 2A). An ultrasound guided biopsy showed metastasis from ovarian cancer corresponding to a PAX8 overexpression on the histological examination ( Figure 2B).