case_images: PMC11126239_01
case_images: Magnetic resonance imaging scan. A circumcised lesion sized 2.5 x 1.7 cm2, presenting adjacent to the left submandibular gland. (a) STIR sequence axial plane, (b) STIR sequence coronal plane
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case_images: A mass, sized 2.5 x 1.7 cm2, was excised under general anaesthesia, as imaged in the preoperative performed magnetic resonance imaging (MRI) [Figure 1], with a diagnosis of a low-grade IC (ICDO: 8500/2), with an infiltrated adjacent lymph node.
case_images: Magnetic resonance imaging scan. A cystic lesion sized 1.3 x 1.1 cm2 is present in the left mucosal area of the upper lip. (a) STIR sequence, axial plane, (b) T2-weighted image, sagittal plane, (c): STIR sequence coronal plane. STIR: Short-TI Inversion Recovery
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case_images: Concerning the current mass, a preoperative MRI presented a central cystic lesion 1.3 x 1.1 cm2, with an intact submandibular gland [Figure 2].
case_images: (a) Clinical presentation of the lesion of the upper lip shows an exophytic mass, well circumcised. (b) the excised specimen. (c) the resected area prior to surgical closure
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case_images: A mucosal incision sized 3 cm was performed on the left side of the upper lip, the submucosal plane was dissected, and the lesion was revealed and excised in clear margins, as a cystic lesion [Figure 3].
case_images: (a) Papillary and focally cystic pattern (haematoxylin and eosin, x40), (b) Intraductal growth. Distended duct with tufted papillary anastomosing proliferations (haematoxylin and eosin, x40), (c) Well circumscribed and unencapsulated at low power (haematoxylin and eosin, x100), (d) Small cuboidal cells with eosinophilic cytoplasm and small, oval nuclei with dispersed chromatin, inconspicuous nucleoli. Low-grade nuclear features. Mild nuclear pleomorphism (haematoxylin and eosin, x200)
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case_images: Histology and immunohistochemistry workup are summarized in Figures 4-7.
case_images: (a) Cytokeratin 7 (+) (x100) (b) Cytokeratin 8/18 (+) (x100) (c) Ki-67 proliferation marker 3% (x200), (d) Pathology image of the previous submandibular lesion present lymph node metastasis, similar to the upper lip lesion (haematoxylin and eosin, x40)
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case_images: Histology and immunohistochemistry workup are summarized in Figures 4-7.
case_images: Demonstration by immunohistochemistry of a myoepithelial layer (p63). (a) x10, (b) x10, (c) x20
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case_images: Histology and immunohistochemistry workup are summarized in Figures 4-7.
case_images: Demonstration by immunohistochemistry of a myoepithelial layer around cell nests (p63). (a) x10, (b) x10
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case_images: Histology and immunohistochemistry workup are summarized in Figures 4-7.