case_images: PMC6278244_01
case_images: PMC6278244_02
case_images: PMC6278244_03
case_images: Histomorphometric analysis of follicle number, atresia, and corpus luteum number of 8 month old FXPM mutants and wild type control animals. Quantification of intact primordial, primary, secondary, pre-antral, and large antral/periovulatory follicles per ovary (n = 4 per genotype) is shown in A-F. Follicle atresia was evaluated by counting atretic large antral follicles (G) and zona pellucida remnants (ZPR, H). Corpus luteum (CL) number is shown in (I). Note increased variability in the number of PM/PM follicles, ZPR, and CL. Statistically different means, where applicable, are denoted by letters "a" and "b," with P-values shown above each plot as calculated by ANOVA analysis..
case_images: fgene-09-00529-g001.jpg
case_images: PMC6278244_03_fgene-09-00529-g001.jpg
case_images: F1
case_images: As shown in Figure 1, mice carrying an FMR1 premutation had a normal number of primordial follicles. The significant differences from control mice were: (1) fewer large antral follicles, (2) fewer corpora lutea, and (3) a greater number of atretic large antral follicles. (Figure 1).
case_images: Percentage change over 3 years in femoral neck (A) and lumbar spine (B) BMD in healthy control women and women with 46,XX sPOI treated with E + P or E + P + T..
case_images: fgene-09-00529-g002.jpg
case_images: PMC6278244_03_fgene-09-00529-g002.jpg
case_images: F2
case_images: An NIH 3-year randomized controlled trial in women with spontaneous 46,XX (normal karyotype) POI demonstrated a 7.7% gain in femoral neck BMD with physiological transdermal estrogen and oral medroxyprogesterone replacement (; Figure 2).
case_images: Changes in serum creatinine (A), plasma renin activity (B), angiotensin II (C) and aldosterone (D) concentrations in women with POI treated with physiologic HRT () or standard OCPs ()..
case_images: fgene-09-00529-g003.jpg
case_images: PMC6278244_03_fgene-09-00529-g003.jpg
case_images: F3
case_images: They also induce unwanted physiologic changes as compared to physiologic hormone replacement (; Figure 3).
case_images: PMC6278244_04
case_images: Schematic flow diagram depicts the process to be followed by the proposed International FXPOI Natural History Study.
case_images: fgene-09-00529-g004.jpg
case_images: PMC6278244_04_fgene-09-00529-g004.jpg
case_images: F4
case_images: There is a need for an International FXPOI Natural History Study (Figure 4).