case_images: PMC9713006_01
case_images: Diffuse erythema with severe ulceration and necrosis on the patient's arms, hands, legs, and feet.
case_images: fmed-09-1065350-g001.jpg
case_images: PMC9713006_01_fmed-09-1065350-g001.jpg
case_images: F1
case_images: In April 2021, cutaneous lesions manifested as diffuse erythema with ulcers, obvious pain, and tenderness appeared over the limbs (Figure 1), but without swelling, fever, or joint pain.
case_images: Histopathological findings of the cutaneous lesions on the left leg. Hyperkeratosis, acanthosis, and obvious angioectasia in the dermal papilla and mild lymphocytic infiltration around the dermal vessels (hematoxylin-eosin, original magnification 10x).
case_images: fmed-09-1065350-g002.jpg
case_images: PMC9713006_01_fmed-09-1065350-g002.jpg
case_images: F2
case_images: There was obvious angioectasia in the dermal papilla and mild lymphocytic infiltrate around the dermal vessels (Figure 2).
case_images: Evident regression of the cutaneous lesions of the patient's arms, hands, legs, and feet after the antiplatelet therapy.
case_images: fmed-09-1065350-g003.jpg
case_images: PMC9713006_01_fmed-09-1065350-g003.jpg
case_images: F3
case_images: After the treatment with aspirin for 2 months, her cutaneous ulcer healed and the diffuse erythema disappeared, with only atrophie blanche and skin hyperpigmentation left (Figure 3).