case_images: PMC11211867_01
case_images: Demyelinating antibody of central nervous system. (A) AQP4 antibodies (1:10) are detected in the serum in the first test (scale bar 20mum). (B) AQP4 antibodies are found negative in the CSF (scale bar 20mum). (C) AQP4 antibodies are found negative in the serum in the second detect (scale bar 20mum). (D) OCBs are found in both serum and CSF, and the locations are identical. AQP4, aquaporin 4; CSF, cerebrospinal fluid; OCBs, oligoclonal bands.
case_images: fimmu-15-1424243-g001.jpg
case_images: PMC11211867_01_fimmu-15-1424243-g001.jpg
case_images: f1
case_images: AQP4-IgG (antibody titer: 1:10, assessed by CBA method) was detected positive in the serum ( Figure 1A ), while no abnormalities were found in the CSF AQP4-IgG ( Figure 1B ). Additionally, we searched for IgG-oligoclonal bands (OCBs) in the CSF and serum using isoelectric focusing electrophoresis analysis. The patient's serum and CSF contained identical IgG-OCBs. ( Figure 1D ). We rechecked that AQP4-IgG in the serum of the patient was negative ( Figure 1C ).
case_images: Abdominal CT and MRI and PET-CT findings in this case. (A) Abdominal CT shows an equal-denstiy mass pointed by the red arrowheads in the left lower abdomen. (B) T1-weighted image shows a hypointense mass pointed by the red arrowheads in the left lower abdomen. (C) T2-weighted image shows a hyperintense mass pointed by the red arrowheads in the left lower abdomen. (D) PET-CT shows no neoplasm indications. CT, computer tomography; MRI, magnetic resonance imaging; PET, positron emission tomography.
case_images: fimmu-15-1424243-g002.jpg
case_images: PMC11211867_01_fimmu-15-1424243-g002.jpg
case_images: f2
case_images: An equal-density mass was seen on the abdominal CT ( Figure 2A ). The PET-CT scan, used to assess the course of treatment after the most recent round of chemotherapy, showed no indications of the tumor ( Figure 2D ).
case_images: Histopathologic findings of the ovarian dysgerminoma in this case. (A) Tumor cell nests are located in the ovarian parenchyma (HE) (scale bar 40mum). (B-D) Immunohistochemistry of tumor tissues show CD117 (+), SALL4 (+), and OCT3/4 (+) in this case (scale bar 40mum). HE, hematoxylin and eosin.
case_images: fimmu-15-1424243-g003.jpg
case_images: PMC11211867_01_fimmu-15-1424243-g003.jpg
case_images: f3
case_images: After undergoing a pathologic biopsy and surgical resection, the neoplasm was diagnosed as an ovarian dysgerminoma ( Figure 3A ). Immunohistochemistry of tumor tissues showed positive results for cluster of differentiation 117 (CD117), spalt-like transcription factor 4 (SALL4), and octamer-binding transcription factor 3/4 (OCT3/4), while negative for epithelial membrane antigen (EMA), CD3, CD20, CD30, pair box gene 8 (PAX-8), human melanoma black 45 (HMB-45), anaplastic lymphoma kinase (ALK), and placental alkaline phosphatase (PLAP) ( Figures 3B-D ).