case_images: PMC9846320_01
case_images: PET-CT revealed an irregular hypodense mass in the lateral segment of left lobe of liver with enhanced FDG drug absorption.
case_images: fonc-12-1090634-g001.jpg
case_images: PMC9846320_01_fonc-12-1090634-g001.jpg
case_images: f1
case_images: Prior to postoperative adjuvant therapy, a PET/CT ( Figure 1 ) scan revealed a mild hypodensity mass with a maximum SUV value of 12.0 in the lateral segment of the left hepatic lobe, which was diagnosed as a malignant tumor.
case_images: Tumor cells were found in the superficial dermis, the whole epidermis, and the inner corneal layer showed as nested sheets or scattered distribution. The ovoid and polygonal tumor cells had a distinct nuclear membrane, and an eosinophilic nucleolus, as well as abundant cytoplasm and melanin granules and an increased nucleoplasm ratio. Phagocytic melanocytes are found in the superficial dermis.
case_images: fonc-12-1090634-g002.jpg
case_images: PMC9846320_01_fonc-12-1090634-g002.jpg
case_images: f2
case_images: Ki-67 was reactive in approximately 40% of the tumor cells ( Figure 2 ).
case_images: Glandular formations of varied size, shape, and irregular arrangement that have invaded the submucosa.
case_images: fonc-12-1090634-g003.jpg
case_images: PMC9846320_01_fonc-12-1090634-g003.jpg
case_images: f3
case_images: MRI showed an irregular soft-tissue mass with low signal intensity on T1WI (A-C) and slightly high signal intensity on T2WI (D-F) in the lateral segment of left hepatic lobe, as well as dilated adjacent bile ducts, and no clear indication of left portal vein.
case_images: fonc-12-1090634-g004.jpg
case_images: PMC9846320_01_fonc-12-1090634-g004.jpg
case_images: f4
case_images: MRCP indicated ( Figure 4 ) multiple liver metastases and biliary obstruction, and tumor progression was considered, so the 4th cycle of immune maintenance therapy was suspended.