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case_images: Histopathologic Examinations of the Primary Tumor Focus in the Left Breast and the Right Breast Before Operation. (A, B) HE-stained images of the primary tumor focus (100x). (C-E) HE-stained images of the tumor focus on the right breast (40x).
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case_images: Figures 2A, B ). Following the diagnosis, the patient began a treatment regimen consisting of 4 cycles of EC regimen (epirubicin 100 mg/m2, Q21d and cyclophosphamide 600 mg/m2, Q21d), followed by 4 cycles of TH regimen (docetaxel 100 mg/m2, Q21d and trastuzumab, 8mg/kg on day1, then 6mg/kg Q21d), along with one year of trastuzumab-targeted therapy (6 mg/kg, Q21d). In November 2021, the patient switched to an RC48 regimen (2.5mg/kg, Q14d) following a right breast aspiration biopsy that revealed tumor cells ( Figures 2C-E ).
case_images: Brush Cytology, Histopathologic, and Immunohistochemical Examinations of Biopsy Tissue from Pulmonary Metastasis. (A-C) Light microscope images of brush cytology; cancer cells are visible (A, C: 200x; B:100). (D, E) HE-stained images of biopsy tissue from the pulmonary metastasis focus (40x). (F, G) PD-L1: Negative (F: 40x; G: 100x).
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case_images: A subsequent ciliary bronchoscopy at our facility confirmed the presence of cancer cells ( Figures 3A-C ). A bronchial specimen biopsy was then conducted, and pathological results showed metastatic invasive carcinoma of the breast, thus clinically indicating breast cancer metastasis ( Figures 3D, E ). Combined Positive Score (CPS) of 0 ( Figures 3F, G ). CA125 level measured on October 10, 2022, was 96.2 U/ml.
case_images: Comparative Chest CT Scans Conducted Before and After the Fifth DS8201 and Tislelizumab Treatment Regimen Cycle. Before: October 10, 2022, After: February 26, 2023.
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case_images: After five cycles, a comparative analysis with pre-treatment CT scans revealed a notable reduction in the size of multiple lung nodules and nodular foci and improved carcinomatous lymphangitis ( Figure 4 ).