case_images: PMC4444256_01
case_images: Subretinal fluid (SRF) in typical active ocular toxoplasmosis as seen by optical coherence tomography (OCT) (Patient 9, Table 1).. 
  Parts A-D: fundus photos (FP) and OCT images on the initial visit. Part A: a fresh whitish inflammatory lesion superior to the macula in the extramacular area, with intraretinal hemorrhage and SRF surrounding the necrosis. Parts B-D: OCT B-scans corresponding to the lines B-D shown in Part A. Vitreous cells were present with normal retinal structure through the fovea (Part B). In areas surrounding the active lesion, SRF was visable (Part C-D). Full-thickness retina destruction (retinal necrosis) accompanied by largely increased choroidal thickness (744 mum) was present (Part D). Parts E-H: FP and OCT images 6 weeks after the initial visit. Part E: previous whitish inflammatory lesion was smaller without visible SRF. Parts F-H: OCT B-scans corresponding to the lines F-H shown in Part E. Absence of SRF and dramatically lessened vitreous cells in the macula and area around the active lesion were observed (Part F-H). Retina got thinner, but still with full-thickness necrosis at the previous active site (Part H). The choroid thickness decreased to 345 mum (Part H). Parts C1-C2 showed the segmentation of retinal layers in OCT B-scan corresponding to Figure C. Part C3-C5: quantitative measurement results from manual segmentation. Part C3: the color bar showing the correlation of thickness and color range. Parts C4-C5: mean retinal thickness and mean SRF height shown in early treatment diabetic retinopathy study (ETDRS) grid using foveola as the center of the grid. The correlation of numbers and subfields are as follows: 1 = superior outer macula; 2 = temporal outer macula; 3 = inferior outer macula; 4 = nasal outer macula; 5 = superior inner macula; 6 = temporal inner macula; 7 = inferior inner macula; 8 = nasal inner macula; 9 = central subfield). ILM = internal limiting membrane; PR = photoreceptor layer; RPE = retinal pigment epithelium.
case_images: pone.0127683.g001.jpg
case_images: PMC4444256_01_pone.0127683.g001.jpg
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case_images: OT in the left eye, presented with new-onset "foggy vision" and pain in the left eye, in addition to persistent headache for a four-day period (Patient 9, Table 1, Fig 1). On presentation, VA was 20/20 in the left eye with 1+ vitreous cell.
case_images: PMC4444256_02
case_images: Subretinal fluid (SRF) associated with cystoid macular edema (CME) in one eye with previous diagnosis of ocular toxoplasmosis as seen on optical coherence tomography (OCT) (Patients 16, Table 1).. 
  Parts A1, B1, C1, D1 showed characteristics of SRF and CME seen on OCT B-scans through the fovea. Parts A2, B2, C2, D2 demonstrated mean retinal thickness maps shown in early treatment diabetic retinopathy study (ETDRS) grid. Parts A3, B3, C3, D3 were maps of mean SRF height shown in ETDRS grid. SRF and CME kept relatively unchanged for the first 3 visits, and started to respond to treatment on the 4th visit. Parts E-K revealed absence of SRF in the following visits, after 3 intraocular injection of 1.25 mg bevacizumab. However, CME remained persistent, although minimization at one time point (H) was temporally seen.
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case_images: PMC4444256_02_pone.0127683.g002.jpg
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case_images: Table 1, Fig 2).