case_images: PMC10848147_01
case_images: PMC10848147_02
case_images: Imaging and genetic results for the patient. (A) Representative CTA image of the patient's brain. (B) On first admission, DW-MRI of the brain shows high signal in the left frontal lobe, the parietal lobe, the occipital lobe, the basal ganglia, and corona radiate, as indicated with red arrows. (C,D) Agitated-saline-contrast echocardiography of the reported patient (C) and a positive control patient with patent foramen ovale (PFO) (D) show bubbles (indicated by yellow arrows) in the left ventricle of the PFO patient but not in the stroke patient (our case). (E) On second admission, DW-MRI of the brain shows high signal in the left frontal and parietal lobes, as indicated by red arrows. (F) SWI-MRI of the brain shows low signal in the left frontal lobes, the parietal lobes, and the left basal ganglia, where the lesions were located on first admission. (G) Pedigree analysis of the patient's family. The patient and his older sister, who both carried FGG c.952G>A, are shown in solid black. Healthy family members are shown in hollow white. The patient, i.e., the proband, is marked with an arrow and his deceased father with a diagonal slash. (H) Sanger sequencing confirms the presence of FGG c.952G>A in the patient and his older sister, and the absence of FGG c.952G>A in his mother and son.
case_images: fneur-15-1272802-g001.jpg
case_images: PMC10848147_03_fneur-15-1272802-g001.jpg
case_images: fig1
case_images: By Sanger sequencing, we further confirmed the presence of this FGG variant in the patient and his sister, but not in his healthy mother or son (Figures 1G,H).
case_images: PMC10848147_03
case_images: Imaging and genetic results for the patient. (A) Representative CTA image of the patient's brain. (B) On first admission, DW-MRI of the brain shows high signal in the left frontal lobe, the parietal lobe, the occipital lobe, the basal ganglia, and corona radiate, as indicated with red arrows. (C,D) Agitated-saline-contrast echocardiography of the reported patient (C) and a positive control patient with patent foramen ovale (PFO) (D) show bubbles (indicated by yellow arrows) in the left ventricle of the PFO patient but not in the stroke patient (our case). (E) On second admission, DW-MRI of the brain shows high signal in the left frontal and parietal lobes, as indicated by red arrows. (F) SWI-MRI of the brain shows low signal in the left frontal lobes, the parietal lobes, and the left basal ganglia, where the lesions were located on first admission. (G) Pedigree analysis of the patient's family. The patient and his older sister, who both carried FGG c.952G>A, are shown in solid black. Healthy family members are shown in hollow white. The patient, i.e., the proband, is marked with an arrow and his deceased father with a diagonal slash. (H) Sanger sequencing confirms the presence of FGG c.952G>A in the patient and his older sister, and the absence of FGG c.952G>A in his mother and son.
case_images: fneur-15-1272802-g001.jpg
case_images: PMC10848147_03_fneur-15-1272802-g001.jpg
case_images: fig1
case_images: By Sanger sequencing, we further confirmed the presence of this FGG variant in the patient and his sister, but not in his healthy mother or son (Figures 1G,H).