case_images: PMC10590066_01
case_images: Clinical presentation of cutaneous metastasis of HCC. Red infiltrative plaques with ulceration and scab on the nasal tip.
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case_images: A red infiltrating nodule was seen on the nasal tip, without peduncles, with a hard and tough texture; the nodule was raised, ulcerated, and covered with a black crust (Figure 1).
case_images: CT scan. There is a hypodense mass in the left hepatic lobe.
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case_images: Whole-body computed tomography (CT) showed irregular liver margins, an enlarged left hepatic lobe, a slightly low-density mass in the left hepatic lobe, an enlarged spleen, and a widened portal vein (Figure 2), findings that were consistent with liver cirrhosis and liver cancer.
case_images: Histopathology. (a) Dense tumour cell masses were seen in the dermis, with sinus-like, nodular, and cord-like distributions (HE, 40x). (b) Some atypical tumour cells, enlarged nucleoplasmic ratio, and irregular arrangement of cancer cells were observed (HE, 400x).
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case_images: Histopathology showed epidermal necrosis with ulceration, a dense tumour cell mass in the dermis, with a sinus-like, nodular and cord-like distribution, and some atypical tumour cells (Figure 3).
case_images: Immunohistochemical analysis. Arg-1(+).
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case_images: Immunohistochemistry of intradermal tumour cells revealed the following: HepPar-1(+), Arg-1(+), CK8(+), Villin(+), CK7(-), CK20(-), and Ki-67 positive (approximately 90%) (Figure 4).