case_images: PMC10560848_01
case_images: (A) Axial contrast-enhanced computed tomography shows right subglottic soft tissue mass (arrow) invading airway; (B) Coronal reformatted contrast-enhanced computed tomography shows mass (arrow) extension from right true vocal cord of glottis to the subglottic region.
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case_images: PMC10560848_01_fonc-13-1222418-g001.jpg
case_images: f1
case_images: A computed tomography (CT) revealed a heterogenous lesion in the subglottic and glottal parts on the right side, measuring 13 x 18 x 25 mm ( Figure 1 ).
case_images: Views from nasofiberoscopy. (A, B) before the treatment with visible right-sided tumor (white arrow); (C, D) after the treatment.
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case_images: PMC10560848_01_fonc-13-1222418-g002.jpg
case_images: f2
case_images: It covered the subglottic region, right vocal fold, anterior and posterior commissures, shallowing the right laryngeal ventricle ( Figure 2 ).
case_images: (A) Hematoxilin and eosin staining of small cell carcinoma with significant crushing artifact (magnification x10); (B) Immunohistochemical stainings confirming diagnosis of small cell carcinoma with neuroendocrine differentiation (magnification x10): 1. CKAE1/AE3 with dot-like pattern, 2. CD56- strong positive membranous staining, 3. synaptophysin- strong positive cytoplasmic staining, 4. Ki67- positive nuclear staining in 99% of tumor cells.
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case_images: PMC10560848_01_fonc-13-1222418-g003.jpg
case_images: f3
case_images: Neoplastic cells showed positive synaptophysin, CD56, and non-specific TTF1 immunohistochemical expression, while immunostainings for chromogranin and LCA were negative ( Figure 3 ).
case_images: Skeletal scintigraphy in (A) A-P and (B) P-A views after Tc99m MDP administration. Numerous metastatic foci within the spine, pelvis, ribs, skull, proximal end of the right femur, and where the prosthesis enters the left femur. Very fast progression of the disease.
case_images: fonc-13-1222418-g004.jpg
case_images: PMC10560848_01_fonc-13-1222418-g004.jpg
case_images: f4
case_images: It confirmed multiple lesions with elevated uptake in the axial skeleton, ribs, pelvis, and structures of the left hip joint ( Figure 4 ).