case_images: PMC6256116_01
case_images: (A) Diffuse erythema of the face and the "V-neck sign," suggestive of dermatomyositis. (B) Computed tomography of the abdomen revealing a prostate tumor (arrow) and (C) an enlarged left iliac lymph node (arrow) (D) Immunohistochemical section of a needle core biopsy from the prostate of the patient showing large cells staining positive for chromogranin A.
case_images: fonc-08-00534-g0001.jpg
case_images: PMC6256116_01_fonc-08-00534-g0001.jpg
case_images: F1
case_images: Upon examination he had a reddish periorbital edema and an erythema of the face and the neck V-region (Figure 1A). A subsequent computed tomography scan of the abdomen revealed a large prostate tumor (Figure 1B), enlarged left iliac lymph nodes (Figure 1C) and a heterogeneous osteosclerosis of the left side of the L1 vertebral body with a collapse of its upper part and paravertebral fat edema, consistent with a metastasis at the L1 vertebra. Immunohistochemical stains were strongly positive for neuroendocrine markers chromogranin A (Figure 1D) and synaptophysin and negative for the CD56 antigen.