case_images: PMC4241562_01
case_images: (a) Prussian-Blue stain showing iron granules in hepatocytes and bile duct epithelium in the explanted liver. (b) PAS-Diastase stain showing alpha 1 antitrypsin globules in periportal hepatocytes in the explanted liver. (c) Prussian-Blue stain showing iron granules in Kuppfer cells in the transplanted liver. (d) Prussian-Blue stain with extensive cytoplasmic iron in cardiac myocytes. (e) Hematoxylin and Eosin stain with intracytoplasmic hemosiderin in myocytes. (f) Prussian-Blue stain high power view of cytoplasmic iron in cardiac myocytes.
case_images: CRIT2014-946961.001.jpg
case_images: PMC4241562_01_CRIT2014-946961.001.jpg
case_images: fig1
case_images: Liver explant showed 3+ iron predominantly within hepatocytes and occasional Kupffer cells with intracytoplasmic alpha-1 antitrypsin globules on periodic acid-Schiff staining, indicative of both iron overload and alpha 1 antitrypsin deficiency (Figure 1).
case_images: Timeline.
case_images: CRIT2014-946961.002.jpg
case_images: PMC4241562_01_CRIT2014-946961.002.jpg
case_images: fig2
case_images: She is currently forty-five days post-op from orthotopic liver transplant and her cardiac functions remain normal (Figure 2).