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case_images: MRI coronal view showed a mass in the nasal cavity (A) and MRI sagittal view showed a heterogeneously enhanced mass (red arrow) at nasal cavity affecting ethmoid sinus, sphenoid sinus and hard palate bone (B).
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case_images: Magnetic resonance imaging (MRI) revealed a mass measuring 20 mm in the nasal cavity, affecting the ethmoid sinus, sphenoid sinus, and hard palate bone (Figure 1).
case_images: Histomorphological details of NC. Tumor was composed of basaloid squamous cells. The periphery of the tumor nests was arranged in a palisade pattern. Focal abrupt keratinization could be seen (A x100; B x400).
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case_images: Abundant cytoplasm, frequent mitotic figures, and focal abrupt keratinization with few keratin pearls were evident (Figure 2).
case_images: Immunohistochemistry staining of tumor cells that were positive for CK (A x200), p40 (B x200) and NUT (D x40; inset x400). Ki-67 index of tumor cells was >60% (C x200).
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case_images: The Ki-67 index was >60% (Figure 3). Shundong Dai, Department of Pathology, Shanghai Ninth People's Hospital), and the diffuse strong staining of NUT was consistent with the FISH data (Figure 3D).
case_images: Fluorescence in situ hybridization demonstrated the gene rearrangement of NUTM1. Large proportion cells showing 1 red 1 green 1 fusion signal, indicating NUTM1 fused with partner genes.
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case_images: Finally, the patient requested a FISH test in our hospital, which demonstrated that the proportion of 1 red 1 green 1 fusion signal was 23%, the proportion of 1 red 1 green signal was 10%, and that of 1 red 1 fusion signal was 5% (Figure 4).