case_images: PMC11142857_01
case_images: (a, b) Endoscopic view of the rectum showing multiple submucosal nodules along with rectal stricture. Red arrow points to submucosal nodules. Blue arrow points to the stricture area. (c) Tumor cells and unremarkable colonic glands. (d) Rectal biopsy showing unremarkable surface mucosa with focal poorly differentiated infiltrating carcinoma in the lamina propria with a signet ring component.
case_images: CRIGM2024-4823396.001.jpg
case_images: PMC11142857_01_CRIGM2024-4823396.001.jpg
case_images: fig1
case_images: Flexible sigmoidoscopy revealed a 5 cm long rectal stricture surrounded by multiple submucosal nodules with no identifiable mucosal masses (Figure 1). Biopsies were obtained, and pathology results indicated a plasmacytoid variant of urothelial cell carcinoma Figure 1.
case_images: (a) GATA positive. Consistent with rectal involvement by urothelial carcinoma (b) CDX2 negative in tumor with normal staining of colonic glands (c) CK20 positive (d) CK7 positive. (e, f) CK7 and CK20 positive. Typically coexpressed in urothelial carcinoma.
case_images: CRIGM2024-4823396.002.jpg
case_images: PMC11142857_01_CRIGM2024-4823396.002.jpg
case_images: fig2
case_images: (a) Bladder biopsy, urothelial carcinoma, plasmacytoid/signet ring/diffuse variant. The tumor involves lamina propria with polypoid cystitis in the overlying urothelium. No surface urothelial dysplasia. (b) Transition of polypoid cystitis (upper) to tumor (lower). (c) The tumor consists of a discohesive population of single cells with eccentric nuclei, eosinophilic cytoplasm, and occasional signet ring forms (H&E stain 200x) (circle).
case_images: CRIGM2024-4823396.003.jpg
case_images: PMC11142857_01_CRIGM2024-4823396.003.jpg
case_images: fig3
case_images: Cystoscopy revealed nonspecific bladder wall thickening, and biopsies confirmed the same pathology as that was found in the rectum Figure 3.