case_images: PMC10889125_01
case_images: (A) Symmetric externally projecting lesions observed in the bilateral commissures of the mouth. (B) Symmetric externally projecting lesions located on both sides of the tongue, as well as scrotal tongue. (C, D) Physical characteristics observed in the proband and family members, including macrocephaly and overgrowth. (E) Lesions between the fingers on the palms. (F) Lesions in the axillary region. (G) Lesions in the inguinal region.
case_images: fonc-14-1323225-g001.jpg
case_images: PMC10889125_01_fonc-14-1323225-g001.jpg
case_images: f1
case_images: A 41-year-old male presented to the oral and maxillofacial surgery department with painless bilateral lesions in the angles of the mouth for over 2 years ( Figure 1A ). The proband reported initial onset on the right side followed by involvement of the left side, with subsequent appearance of similar lesions on both sides of the tongue after 6 months ( Figure 1B ). Clinical examination revealed speech and non-verbal communication impairments in the proband, along with macrocephaly in both the proband and his brother (head circumference: 66 cm; 69 cm), accompanied by excessive growth and obesity.  Figure 1C  illustrates the proband, while  Figure 1D  depicts the proband's younger brother. Skin examination revealed multiple firm, flesh-colored papillary lesions in the interdigital spaces of the palms, axillae, and groin regions ( Figures 1E, F ).