case_images: PMC11833745_01
case_images: Basal cell carcinoma: initial presentation to dermatology clinic. Ulcerated lesions to the left zygomatic region of the face, right upper forehead, right medial and lateral cheek, and right superior side of the neck.
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case_images: PMC11833745_01_gr1.jpg
case_images: fig1
case_images: She also had multiple skin-colored nodules on the face and side of the neck (Fig 1).
case_images: Basal cell carcinoma: photomicrograph of retraction artifact (red arrow), peripheral palisade (black arrow), eccrine differentiation (white arrow), sheets of basaloid epithelial cells (blue arrow), fibro-myxoid stroma (green arrow; hematoxylin-eosin, magnification x4).
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case_images: PMC11833745_01_gr2.jpg
case_images: fig2
case_images: Histology revealed surface ulceration and infiltration by epithelial cells with high nuclear-to-cytoplasmic ratio, and minimal cytoplasm with high tumor cells forming cords with some evidence of palisading and eccrine differentiation (Fig 2).
case_images: BCC: status post excision of left zygomatic BCC tumor and flap reconstruction. BCC, Basal cell carcinoma.
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case_images: PMC11833745_01_gr3.jpg
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case_images: Management constituted surgical excision of the large, ulcerated nodule on the left cheek with flap reconstruction (Fig 3) by plastic surgery.
case_images: A, BCC: Six weeks after surgery with 5-FU application (green arrows). B, BCC: 8 weeks postsurgery following carbon dioxide ablation laser therapy, 5-FU application (green arrows), and application of mupirocin ointment (yellow arrows). BCC, Basal cell carcinoma.
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case_images: PMC11833745_01_gr4.jpg
case_images: fig4
case_images: During this 6-week period, 5-fluorouracil (5-FU) cream was also applied to the lesions as an adjunct therapy (Fig 4, A). She was noted on her follow-up visit to have reepithelialization on all facial lesions except the right cheek and left side of the nasal bridge while the flap was healing well (Fig 4, B).