case_images: PMC6332809_01
case_images: (A) A microphotograph of the blood smear showing small lymphoid cells with dense chromatin. Their nucleoli and their cytoplasmic expansions suggested the hypothesis of a T-prolymphocytic neoplasm. (B) Complex karyotype involving no less than six pairs of chromosomes, forming a typical profile of T-PLL. (C) FISH analysis.
case_images: CCR3-7-24-g001.jpg
case_images: PMC6332809_01_CCR3-7-24-g001.jpg
case_images: ccr31528-fig-0001
case_images: Cytoplasmic expansions (blebs) were present (Fig. 1A). Furthermore, these abnormal nuclei could be subdivided in two different type, as a first one carried an additional monosomy of chromosome 15, and a second carried a rearrangement in both long arms of chromosomes 1 and 3, suggesting a potential translocation t(1;3) (Fig. 1B). Among these abnormalities, 14 inversion is a characteristic lesion of T -PLL, which is frequently included in complex karyotype. ATM involvement is also recurrent 3 (Fig. 1C).