case_images: PMC524360_01
case_images: Sagittal MRI image of brain at first cerebral relapse demonstrating an enhancing left parasagittal lesion with surrounding cerebral oedema.
case_images: 1471-2407-4-74-1.jpg
case_images: PMC524360_01_1471-2407-4-74-1.jpg
case_images: F1
case_images: MRI of the brain and spine demonstrated a left parasagittal tumor with radiographic features consistent with a meningioma (see Figure 1).
case_images: Photomicrograph of cerebral metastases showing sheets of epithelioid and spindle cells, (H&E x 200)
case_images: 1471-2407-4-74-2.jpg
case_images: PMC524360_01_1471-2407-4-74-2.jpg
case_images: F2
case_images: Histopathology demonstrated metastatic GIST (CD117 positive) (see Figures 2 and 3).
case_images: Immunohistochemical stain for CD117 (c-kit) showing staining of the cell membrane and Golgi region of the tumor cells, (x 400)
case_images: 1471-2407-4-74-3.jpg
case_images: PMC524360_01_1471-2407-4-74-3.jpg
case_images: F3
case_images: Histopathology demonstrated metastatic GIST (CD117 positive) (see Figures 2 and 3).
case_images: DNA sequence of part of exon 9 of c-kit for control (lower) and patient tumour (upper) samples. The patient's tumour sample contained a GCCTAT duplication
case_images: 1471-2407-4-74-4.jpg
case_images: PMC524360_01_1471-2407-4-74-4.jpg
case_images: F4
case_images: An in-frame GCCTAT insertion/duplication in exon 9 of c-kit in the original jejunal tumor, the liver and the cerebral metastases were detected (See Figure 4).