case_images: PMC5968294_01
case_images: CT scan of abdomen without visible calcification of the mesenteric vein and its contributories. Colonic wall thickened.
case_images: crg-0012-0137-g01.jpg
case_images: PMC5968294_01_crg-0012-0137-g01.jpg
case_images: F1
case_images: A CT scan showed a paralytic ileus with increased thickness of the colonic wall but without signs of threadlike calcification of the mesenteric vein or its tributaries (Fig. 1).
case_images: Macroscopic and microscopic pictures of the left-sided colonic wall. a Extensive necrosis of mucosa and submucosa. Red bracket marks area of histology, with von Kossa staining showing extensive calcification of the submucosal area. Original magnification 25x. b Details of venous wall with H&E, CD31, EVG, and Kongo-red staining showing submucosal calcification with luminal narrowing. Immune histology reveals preserved endothelial layer with submucosal calcification without inflammation. c Calcification of the submucosal veins. H&E staining. Original magnification 100x.
case_images: crg-0012-0137-g02.jpg
case_images: PMC5968294_01_crg-0012-0137-g02.jpg
case_images: F2
case_images: Upon gross examination, a thickened colonic wall, together with a necrotic mucosal epithelium and mural calcifications, suggested a vascular-mediated disease (Fig. 2a, inset). Histologically, the colonic wall showed extensive calcifications of the submucosal layer with long-stretched mucosal ulcerations (Fig. 2a). Interestingly, only submucosal veins showed a subtotal occlusive fibrosis, sclerosis, and calcification (Fig. 2b). The calcification was confirmed by von Kossa stain (Fig. 2c), leading to the rare diagnosis of PC.