case_images: PMC6012565_01
case_images: Infiltration of the cerebral cortex from a moderately differentiated adenocarcinoma (H&E x100).
case_images: esmoopen-2018-000329f01.jpg
case_images: PMC6012565_01_esmoopen-2018-000329f01.jpg
case_images: F1
case_images: Histology confirmed the presence of metastasis with morphology and immunophenotype consistent with gastrointestinal origin (figure 1).
case_images: Tested genes per site of neoplastic material or cell-free DNA that was subjected to next-generation sequencing. Muutated genes are depicted in dark.
case_images: esmoopen-2018-000329f02.jpg
case_images: PMC6012565_01_esmoopen-2018-000329f02.jpg
case_images: F2
case_images: Next Generation Sequencing of 50 cancer-related genes was thus applied in all resected neoplastic material available (figure 2).
case_images: Mutational evolution of the tumour in the various sites over time. CAPOX, capecitabine/oxaliplatin; FOLFIRI, folinic acid/5-fluorouracil/irinotecan; met, metastasis; res'd, resected; SCLN, subclavicular lymph node.
case_images: esmoopen-2018-000329f03.jpg
case_images: PMC6012565_01_esmoopen-2018-000329f03.jpg
case_images: F3
case_images: The clonal make-up of the malignancy over time is summarised in figure 3.