case_images: PMC10624085_01
case_images: (A) Indurated non-pruritic purplish plaques on the medial aspect of thighs. (B) Erythematous mucous plaques discovered on bronchoscopy in the endobronchial area. (C) Histopathology of cutaneous skin lesion from the thigh showing endothelial cells stained immunohistochemically with diaminobenzidine anti-CD31 stain (10x). (D) Nuclear staining with HHV-8 stain (10x) from the thigh lesion biopsy.. Abbreviations: HHV-8, human herpesvirus 8; CD31, cluster of differentiation 31.
case_images: 10.1177_23247096231208996-fig1.jpg
case_images: PMC10624085_01_10.1177_23247096231208996-fig1.jpg
case_images: fig1-23247096231208996
case_images: The lesions on the thighs became progressively more painful, indurated, and larger in size (Figure 1A). They were visually consistent with endobronchial KS (Figure 1B). Skin biopsy from his thigh and chest lesions stained positive by immunohistochemistry for co-expression of the endothelial marker cluster of differentiation 31 (CD31) and HHV-8 (Figure 1C and D), confirming cutaneous KS.
case_images: (A) CT chest indicating bilateral pleural effusion and scattered ground glass opacities. (B) Worsening ground glass opacities and alveolar infiltration on second hospitalization. (C) Left upper renal pole 1 cm hypodensity. (D) Subtle hepatic hypodensities worse in left hepatic lobe suggestive of disseminated KS.. Abbreviations: CT, computed tomography; KS, Kaposi sarcoma.
case_images: 10.1177_23247096231208996-fig2.jpg
case_images: PMC10624085_01_10.1177_23247096231208996-fig2.jpg
case_images: fig2-23247096231208996
case_images: Computed tomography (CT) of the chest showed moderate basilar posterior partially loculated pleural effusions, worse on the left, extensive scattered ground glass infiltrates, worse on the right, and scattered alveolar consolidations without any pulmonary embolus with small bilateral hilar lymph nodes and slight pericardial effusion (Figure 2A). Repeat CT chest revealed worsening consolidation concerning for pneumonia or the progression of pulmonary KS (Figure 2B).