case_images: PMC9929652_01
case_images: Family 1 pedigree.   = deceased; numbers correspond to age at time of presentation; +/- indicates HBsAg and HBsAb status, respectively. Larger arrow indicates the propositus.
case_images: crg-2022-0017-0001-529153_f1.jpg
case_images: PMC9929652_01_crg-2022-0017-0001-529153_f1.jpg
case_images: F1
case_images: HCC at 36, 6 years before, while his 38-year-old brother and 36-year-old sister both, HBsAg (+), are not on antiviral therapy. His youngest sister, also HBsAg (+), died of a myocardial infarction at age 31 (Fig. 1).
case_images: Family 2 pedigree.   = deceased; numbers correspond to age at time of presentation; +/- indicates HBsAg and HBsAb status, respectively. Larger arrow indicates the propositus.
case_images: crg-2022-0017-0001-529153_f2.jpg
case_images: PMC9929652_01_crg-2022-0017-0001-529153_f2.jpg
case_images: F2
case_images: Among her three sons, all perinatally infected, one died of HCC at the age of 44, while two others (ages 42 and 46) have CHB on treatment (Fig. 2).
case_images: Family 3 pedigree.   = deceased; numbers correspond to age at time of presentation; +/- indicates HBsAg and HBsAb status, respectively. Larger arrow indicates the propositus.
case_images: crg-2022-0017-0001-529153_f3.jpg
case_images: PMC9929652_01_crg-2022-0017-0001-529153_f3.jpg
case_images: F3
case_images: These three daughters presented with 3 different clinical manifestations, while their mother died of HCC (Fig. 3).
case_images: PMC9929652_02
case_images: PMC9929652_03
case_images: Family 4 pedigree.   = deceased; numbers correspond to age at time of presentation; +/- indicates HBsAg and HBsAb status, respectively. Larger arrow indicates the propositus.
case_images: crg-2022-0017-0001-529153_f4.jpg
case_images: PMC9929652_03_crg-2022-0017-0001-529153_f4.jpg
case_images: F4
case_images: HCC at 58 and in her 70's, respectively. Her older (6 years older) brother died of unknown cause (Fig. 4).