case_images: PMC10828739_01
case_images: (1A) The mastectomy specimen shows acinar cells with cytoplasmic granules (hematoxylin & eosin stain, x200). (1B) The granules are more prominent and dot-like (hematoxylin & eosin stain, x400)
case_images: cureus-0016-00000051427-i01.jpg
case_images: PMC10828739_01_cureus-0016-00000051427-i01.jpg
case_images: FIG1
case_images: Many of the cells contained granular cytoplasm, and some cells were clear or multivacuolated, resembling lipoblasts (Figure 1A-1B).
case_images: (2A) A figure shows the cells with eccentric nuclei and prominent nucleoli, eosinophilic cytoplasmic granules admixed with some cells that show clear or multivacuolated resembling lipoblasts (hematoxylin & eosin stain, X400). (2B) A section showed that these cells are set in the background of hyalinized stroma (hematoxylin & eosin stain, x200)
case_images: cureus-0016-00000051427-i02.jpg
case_images: PMC10828739_01_cureus-0016-00000051427-i02.jpg
case_images: FIG2
case_images: The tumor showed hyalinized stroma in some areas (Figure 2A-2B).
case_images: (3A) A figure shows acinar cells containing abundant diastase-resistant, PAS-positive cytoplasmic granules (PAS-D stain) (PAS-D, x400). (3B) This section reveals that the case is immunoreactive for DOG-1 (DOG-1 stain, X200)
case_images: cureus-0016-00000051427-i03.jpg
case_images: PMC10828739_01_cureus-0016-00000051427-i03.jpg
case_images: FIG3
case_images: The immunohistochemistry workup revealed that the case was positive for discovered on gastrointestinal stromal tumors-1 (DOG-1) and the positivity pattern ranged from apical membranous, cytoplasmic, and complete membranous (Figure 3A-3B).