case_images: PMC10513804_01
case_images: Mal de Meleda clinical features of hands and elbows: (a) hyperkeratotic plaque in left hand and desquamation in right hand, (b) keratoderma on the dorse of hands was limited to proximal phalanges and nail involvement characterized by koilonychia, onycholysis, yellowish chromonychia, and dystrophy, and (c) hyperkeratotic-lichenified plaques on elbows with slight desquamation.
case_images: CRIDM2023-6640311.001.jpg
case_images: PMC10513804_01_CRIDM2023-6640311.001.jpg
case_images: fig1
case_images: The elbows had hyperkeratotic lichenified plaques, and fingertips showed loss of dermatoglyphics (Figure 1).
case_images: Mal de Meleda clinical features of feet, soles, and knees: (a) Soles with thick, yellowish, and waxy keratoderma and fingertips with desquamation and erythematous background. (b) Scaly hypochromic plaques on feet dorse and nail involvement of both feet. Foot nails with dystrophy, slight onychogryphosis, yellowish chromonychia, and koilonychia. (c) Knees with hyperkeratotic small plaques, scaly points, and loss of body hair. (d) Left knee with hyperkeratotic plaque and slight desquamation.
case_images: CRIDM2023-6640311.002.jpg
case_images: PMC10513804_01_CRIDM2023-6640311.002.jpg
case_images: fig2
case_images: The knees had hyperkeratotic plaques and scaly points, and loss of body hair (Figure 2).
case_images: Histopathological images of the patient with hematoxylin and eosin staining: (a) right hand (10x), (b) right knee (10x), (c) right elbow (10x), and (d) right elbow (40x).
case_images: CRIDM2023-6640311.003.jpg
case_images: PMC10513804_01_CRIDM2023-6640311.003.jpg
case_images: fig3
case_images: The histological report presented a nonepidermolytic hyperkeratosis characterized by scant lymphocytic infiltrate around the papillary vessels and a thick plug of compact keratin that compressed the epidermis, which presented a thick granular layer and acanthosis with regular hyperplasia of the networks (Figure 3).