case_images: PMC9852885_01
case_images: Liver perfusion analysis revealed incomplete lobular structure, partial hydrolysis of some hepatocytes, infiltration of a few lymphocytes into the portal area, and mild hyperplasia of the fibers. These observations were consistent with the pathological changes observed in G1S1 chronic hepatitis (A): Original magnification: 100x; (B): Original magnification: 200x).
case_images: fped-10-990729-g001.jpg
case_images: PMC9852885_01_fped-10-990729-g001.jpg
case_images: F1
case_images: These observations were consistent with the pathological changes observed in G1S1 chronic hepatitis (Figure 1).
case_images: A liver biopsy under an electron microscope showed that the liver tissue was slightly swollen with a reduced endoplasmic reticulum, slight hyperplasia, expansion of the smooth endoplasmic reticulum, and blurred mitochondrial structures. Most of the hepatocytes showed a slight increase in the number of small lipid droplets in their cytoplasm, with few showing depositions of not many cholestatic pigment particles. The gaps between hepatocyte surfaces were slightly wider, and a few capillary bile ducts were somewhat dilated and cholestatic. Hepatic stellate cells were prominent in the Disse cavity, and focal bundles of collagen fibers were deposited. Kupffer cells were observed in the hepatic sinusoids with no portal area.
case_images: fped-10-990729-g002.jpg
case_images: PMC9852885_01_fped-10-990729-g002.jpg
case_images: F2
case_images: Kupffer cells were observed in the hepatic sinusoids with no portal area (Figure 2).
case_images: High-precision clinical display PLUS detection revealed a heterozygous GOF mutation (p.R274W) in the CC domain of the transcription factor STAT1.
case_images: fped-10-990729-g003.jpg
case_images: PMC9852885_01_fped-10-990729-g003.jpg
case_images: F3
case_images: High-precision clinical display PLUS detection revealed a heterozygous GOF mutation (p.R274W) in the coiled-coil (CC) domain of the transcription factor STAT1 (Figure 3).
case_images: Serial radiologic investigations of the chest. (A and B): 2018.08.16 Infection in the upper middle lobe of the right lung, increased bilateral axillary lymph nodes. (C and D): 2019.01.17 Infection in the upper lobe of the right lung and lower lobe of both lungs, the lesions in the upper lobe of the right lung were slightly larger than before (2018-08-16); bilateral axillary lymph nodes increased. (E and F): 2021.08.16 The transparency of both lungs is uneven, considering the possibility of bronchiolitis, please combine the clinical; Mediastinal lymph node enlargement.
case_images: fped-10-990729-g004.jpg
case_images: PMC9852885_01_fped-10-990729-g004.jpg
case_images: F4
case_images: Serial radiological investigations of the chest were conducted (Figure 4).