case_images: PMC10858767_01
case_images: Pap stain: (a: x20; b: x40) Clusters of epithelial cells with high nucleocytoplasmic ratio; hyperchromatic nuclei; prominent nucleoli; nuclear overcrowding; and indistinct cell borders, (c: x20; d: x40) mesenchymal element demonstrating cigar-shaped to spindle cells (arrows) with clusters of inflammatory cells.
case_images: Cytojournal-21-2-g001.jpg
case_images: PMC10858767_01_Cytojournal-21-2-g001.jpg
case_images: F1
case_images: Papanicolaou (Pap)-stained ThinPrep showed atypical hyperchromatic-crowded groups (HCGs) [Figure 1].
case_images: Left vaginal biopsy; (a: H&E, x4; b: H&E, x10; c: H&E, Zoomed) demonstrated sheets of pleomorphic spindle cells with variable cellularity. (d-f: immunohistochemistry, x10) focal immunoreactivity for CAM5. 2, aberrant p53 expression, and non-immunoreactivity for desmin.
case_images: Cytojournal-21-2-g002.jpg
case_images: PMC10858767_01_Cytojournal-21-2-g002.jpg
case_images: F2
case_images: Histopathological examination (H&E) of the left vaginal biopsy [Figure 2a and 2b] revealed high-grade carcinoma with sarcomatoid features. Immunohistochemistry demonstrated [Figure 2c] focal immunoreactivity for cytokeratin CAM 5.2 [Figure 2d] with mutant p53 expression [Figure 2e] and nonimmunoreactivity for desmin [Figure 2f].