case_images: PMC10834885_01
case_images: CT scan images of the patient. A. CT scan image showing the ileocolic intussusception (arrow) in the 48-year-old patient with Large Cell Neuroendocrine Carcinoma (LCNEC). B. The patient had multiple lesions in the liver (arrows) at presentation suggestive of hepatic metastasis.
case_images: cureus-0016-00000051546-i01.jpg
case_images: PMC10834885_01_cureus-0016-00000051546-i01.jpg
case_images: FIG1
case_images: CT scan revealed both an ileocolic intussusception (Figure 1A) and several hypodense masses in the liver suggestive of metastasis (Figure 1B).
case_images: Gross examination and histopathology images. (A, B). Gross images show ileocolic intussusception (black arrow) opened to reveal a fungating ulcerated cecal pole tumor. The serosa and the appendix are not involved. (C, D). Organoid and pseudo glandular patterns of neoplastic cells. E. Large cells with pleomorphism, moderate to abundant eosinophilic cytoplasm, and prominent nucleoli F. Synaptophysin immunohistochemistry (IHC).
case_images: cureus-0016-00000051546-i02.jpg
case_images: PMC10834885_01_cureus-0016-00000051546-i02.jpg
case_images: FIG2
case_images: On gross examination, the intussuscepted region was opened to show an 8 x 5 x 3 cm ulcerated mass in the cecum with hyperemia and edema of the proximal ascending colon (Figures 2A, 2B). The malignant cells were arranged in organoid-like forms with central necrosis, and focal rosette-like, and trabecular growth patterns were identified, as well (Figures 2C-2E). Immunohistochemical stains were performed, and the cells co-expressed chromogranin and synaptophysin (Figure 2F) with a Ki-67 proliferative index of 60-70%.