case_images: PMC10518453_01
case_images: Images of esophageal squamous cell carcinoma on initial diagnosis. (A) An upper gastrointestinal endoscopy revealed a squamous cell carcinoma in the middle of the esophagus. (B) Enhanced computed tomography revealed mediastinal lymph node metastasis (yellow arrow).
case_images: fimmu-14-1259071-g001.jpg
case_images: PMC10518453_01_fimmu-14-1259071-g001.jpg
case_images: f1
case_images: Upper gastrointestinal endoscopy revealed an advanced circular cancer in the middle of the esophagus ( Figure 1A ). Enhanced computed tomography (CT) revealed mediastinal lymph node metastasis ( Figure 1B ).
case_images: Computed tomography findings. (A, B) Pretreatment computed tomography (CT) scan. (C, D) CT scan after two cycles of ipilimumab and nivolumab. A decrease in the size of lung tumors was noted. Yellow arrows indicate multiple lung metastases.
case_images: fimmu-14-1259071-g002.jpg
case_images: PMC10518453_01_fimmu-14-1259071-g002.jpg
case_images: f2
case_images: In August 2022, a year after surgery, follow-up CT revealed multiple lung metastases ( Figures 2A, B ). Despite ceasing cancer therapy, the combined ICI treatment led to a durable and partial response ( Figures 2C, D ).
case_images: Findings of pemphigus vulgaris. (A) Erosions with pruritus on the trunk. (B) Hematoxylin-eosin stain (x400) of an intra-epidermal blister demonstrating acantholysis and the loss of keratinocyte intercellular adhesion.
case_images: fimmu-14-1259071-g003.jpg
case_images: PMC10518453_01_fimmu-14-1259071-g003.jpg
case_images: f3
case_images: After two cycles of ICI combination therapy (86 days from the first ICI dose), erosions with pruritus developed on the patient's trunk, especially around the implanted central venous port ( Figure 3A ). Blister cavities contained inflammatory cells, including eosinophils and rounded acantholytic cells ( Figure 3B ).