case_images: PMC7522604_01
case_images: Kidney biopsy: representative light microscopy shows global collapse of the glomerular capillary loops accompanied by hyperplasia and hypertrophy of overlying glomerular epithelial cells (a-c) many of which contain scattered eosinophilic protein droplets (a, arrow) and numerous intracytoplasmic vacuoles (b, arrows). a: Jones methenamine silver stain; b: H&E stain; c: Masson's trichrome stain, x400. Acute tubular injury is manifest in many cortical tubules, accompanied by interstitial edema and patchy interstitial mononuclear inflammatory infiltrates (d: H&E stain, x400).
case_images: CRIN2020-8820713.001.jpg
case_images: PMC7522604_01_CRIN2020-8820713.001.jpg
case_images: fig1
case_images: All but one displayed segmental or global collapse, implosion of the glomerular capillary tuft, and enlargement of Bowman space (Figure 1).
case_images: Changes in serum creatinine and proteinuria with time in a 48-year-old African male admitted for acute kidney injury with COVID-19.
case_images: CRIN2020-8820713.002.jpg
case_images: PMC7522604_01_CRIN2020-8820713.002.jpg
case_images: fig2
case_images: The patient received pulse therapy with methyl prednisolone intravenously, 500 mg on days 1, 2, and 3, and cyclophosphamide intravenously, 500 mg day 1; despite this therapy, proteinuria remains still heavy (4 g per day).  Figure 2 shows changes in serum creatinine and proteinuria with time.