case_images: PMC10845073_01
case_images: 200X magnification. Hematoxylin and eosin stains show ill-defined, interweaving vascular channels. Immunohistochemistry showed that the lesional cells were positive for HHV and endothelial markers CD34 and D2-40.. HHV: Human herpes virus.
case_images: cureus-0016-00000051782-i01.jpg
case_images: PMC10845073_01_cureus-0016-00000051782-i01.jpg
case_images: FIG1
case_images: The biopsy was consistent with Kaposi's sarcoma, with immunohistochemistry confirming HHV8 (Figure 1).
case_images: Right medial foot lesion
case_images: cureus-0016-00000051782-i02.jpg
case_images: PMC10845073_01_cureus-0016-00000051782-i02.jpg
case_images: FIG2
case_images: Right toe lesion
case_images: cureus-0016-00000051782-i03.jpg
case_images: PMC10845073_01_cureus-0016-00000051782-i03.jpg
case_images: FIG3
case_images: PMC10845073_02
case_images: Initial radiation therapy treatment
case_images: cureus-0016-00000051782-i04.jpg
case_images: PMC10845073_02_cureus-0016-00000051782-i04.jpg
case_images: FIG4
case_images: The clinical target volume included the skin of the entire right foot and the medial aspect of the right ankle up to an approximate depth of 0.5 cm (Figure 4).
case_images: Pre-treatment images of the right foot; note the areas of discoloration involving the medial foot
case_images: cureus-0016-00000051782-i05.jpg
case_images: PMC10845073_02_cureus-0016-00000051782-i05.jpg
case_images: FIG5
case_images: Several small purple papules/nodules on the right foot and 2+ pitting edema on the right lower extremity were also observed (Figure 5).
case_images: PMC10845073_03
case_images: Radiation dose color wash of the right lower leg planned using volumetric modulated arc therapy (VMAT)
case_images: cureus-0016-00000051782-i06.jpg
case_images: PMC10845073_03_cureus-0016-00000051782-i06.jpg
case_images: FIG6
case_images: He was treated with a course of radiation therapy using 6MV VMAT to a total dose of 3300 cGy in 11 fractions using a Varian IX linear accelerator, with the treatment volume including the skin of the right foot, ankle, and distal right leg to a depth of 0.5 cm (Figure 6).