case_images: PMC10585257_01
case_images: Ultrasound and computed tomography (CT) images of a tumor. (A) A hypoechoic mass measuring 65.4 mm x 34.1 mm x 57.5 mm in the right lobe. (B) The hypoechoic mass with rich blood flow signals in the right lobe. (C) A hypoechoic nodule with microcalcifications in the isthmus lobe. (D) A CT scan of the neck revealed an uneven thyroid gland with a slightly low-density mass in the isthmus and right lobe, ranging approximately 5.3 cm x 4.3 cm.
case_images: fonc-13-1248830-g001.jpg
case_images: PMC10585257_01_fonc-13-1248830-g001.jpg
case_images: f1
case_images: In particular, two hypoechoic nodules were detected: one in the right lobe, measuring 65.4 mm x 34.1 mm x 57.5 mm, and the other in the isthmus lobe, measuring 8.5 mm x 5.2 mm x 5.7 mm ( Figures 1A-C ). A preoperative computed tomography (CT) scan of the neck revealed an uneven thyroid gland with a slightly low-density mass in the isthmus and right lobe, ranging approximately 5.3 cm x 4.3cm ( Figure 1D ).
case_images: Histologic and immunohistochemical images of a primary thyroid lymphoma in the right lobe. (A) Microscopically, a histologic analysis of hematoxylin and eosin staining (x4) revealed that much of the normal thyroid architecture was replaced by dense, diffuse infiltrates of large atypical lymphocytes. Several scattered reactive germinal centers were also observed in the histologic sections. (B) Histologic analysis of hematoxylin and eosin staining (x40) revealed that the lymphomas were composed of a monotonous population of large atypical lymphocytes with irregular nuclei, condensed chromatin, and small nucleoli. (C-H) Immunohistochemical staining showing positive expressions for CD20 (x4), PAX-5 (x4), Ki-67 (x4), and Kappa (x20) and negative expressions for CyclinD1 (x10) and Lambda (x20).
case_images: fonc-13-1248830-g002.jpg
case_images: PMC10585257_01_fonc-13-1248830-g002.jpg
case_images: f2
case_images: The hematoxylin and eosin (H&E) staining of the right lobectomy sample revealed that much of the normal thyroid architecture was replaced by dense, diffuse infiltrates of large atypical lymphocytes with irregular nuclei, condensed chromatin, and small nucleoli ( Figures 2A, B ). Moreover several scattered reactive germinal centers were seen ( Figure 2A ). TdT (-), CyclinD1 (-), PAX-5(+), PD-1 (-), P53 (+, 40%-50%), Ki-67 (+, 60%-70%), Kappa (+), and Lambda (-) ( Figures 2C-H ).