case_images: PMC4717649_01
case_images: Hives developed on mid-back and right forearm 20 minutes following ingestion of full dose of amoxicillin
case_images: 13256_2016_801_Fig1_HTML.jpg
case_images: PMC4717649_01_13256_2016_801_Fig1_HTML.jpg
case_images: Fig1
case_images: The oral challenge was positive as she developed hives 20 minutes following ingestion of the full dose (Fig. 1).
case_images: PMC4717649_02
case_images: a. Erythematous maculopapular rash that coalesced to form large raised plaques developed on day 8 of treatment with amoxicillin. b. Erythematous plaques developed on his face, back, thighs and arms 18 hours following oral challenge to amoxicillin
case_images: 13256_2016_801_Fig2_HTML.jpg
case_images: PMC4717649_02_13256_2016_801_Fig2_HTML.jpg
case_images: Fig2
case_images: On the eighth day of treatment, he developed a maculopapular rash (Fig. 2a) that coalesced to form large raised plaques. He had no reactions initially, but approximately 18 hours later he developed non-pruritic erythematous plaques on his face, thighs and arms (Fig. 2b).
case_images: PMC4717649_03
case_images: a. Hives developed throughout his body on day 3 of treatment with amoxicillin. b. Hives developed 15 minutes following ingestion of one tenth of weight-based dose of amoxicillin. c. Results of intradermal testing showing wheal size of 8x16 mm (wheal/erythema)
case_images: 13256_2016_801_Fig3_HTML.jpg
case_images: PMC4717649_03_13256_2016_801_Fig3_HTML.jpg
case_images: Fig3
case_images: A healthy 14-month-old Chinese boy presented with hives on the third day of amoxicillin treatment for otitis media shortly after he woke up from his sleep and prior to his morning dose (Fig. 3a). The oral challenge was positive because he developed hives 15 minutes (Fig. 3b) following ingestion of one tenth of his weight-based dose of amoxicillin. An intradermal test with Pre-Pen  (benzylpenicilloyl polylysine) was positive (Fig. 3c).