case_images: PMC10543409_01
case_images: (A) shows a diffusely swollen left breast with shiny skin (blue arrow). (B and C) are ultra-sonographic images of the breast showing multiple large hypoechoic masses (blue stars) (4.95cm by 4.96cm and 5.82 cm) respectively, regularly shaped with no calcifications. (D) shows a touch imprint with medium-sized cells, coarse chromatin, and occasional tingible body macrophages (see black arrow).
case_images: CMAR-15-1047-g0001.jpg
case_images: PMC10543409_01_CMAR-15-1047-g0001.jpg
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case_images: Ultrasonography revealed multiple regular hypoechoic masses with no speculated edges commonly seen in breast carcinoma and no calcifications (see Figure 1). Touch imprints of the cores were suggestive of BL (see Figure 1).
case_images: (A) (x20) shows an H&E stained section of the tumor with medium-sized cells, a high N: C ratio, and numerous tingible body macrophages (black arrows) giving it a characteristic starry sky. (B) shows a reduction in the size of the breast a week after her first cycle of chemotherapy with striae seen on the upper border of the breast (black arrowhead).
case_images: CMAR-15-1047-g0002.jpg
case_images: PMC10543409_01_CMAR-15-1047-g0002.jpg
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case_images: H&E stained histology sections revealed a monomorphic population of moderately sized lymphoid cells with a high N:C ratio, frequent apoptotic bodies, frequent mitoses, and occasional tingible body macrophages giving it a starry sky appearance (see Figure 2). The tumor had significantly shrunk, the skin was no longer shiny (see Figure 2B) and she was much happier.
case_images: IHC stains showing positive CD45, Pax5, and c-MYC ((A-C) respectively) (x20). (D) shows 100% expression of Ki67. Panels E and F show negative Tdt and CD3 respectively.
case_images: CMAR-15-1047-g0003.jpg
case_images: PMC10543409_01_CMAR-15-1047-g0003.jpg
case_images: f0003
case_images: Tdt, BCL2, and CD3 were dead negative (see Figure 3).