case_images: PMC11233183_01
case_images: (a) (A) Clinical and (B) dermatoscopic picture (b) Low power views (25X): (A) HE shows a well-demarcated ulcerative skin lesion composed of a mixture of inflammatory cells and sparse EBV-transformed B-cells ((B). EBER ISH); and bordered at the periphery by small T-cells. (c) High power views (400X): (A) shows a polymorphic lymphoplasmacytic infiltrate with interspersed large atypical, Hodgkin/Reed-Sternberg-like cells (insert), expressing CD30 (B), PAX5 (C), EBV-LMP1 (D), but no EBNA2 (E), corresponding to an EBV latency type II. (F) The absence of NCAM/CD56 expression in the large EBV + cells excluded the possibility of an extranodal NK/T-cell lymphoma.
case_images: CRIHEM2024-6883657.001.jpg
case_images: PMC11233183_01_CRIHEM2024-6883657.001.jpg
case_images: fig1
case_images: A 68-year-old male presented with a progressive nodular tumor on his left nostril, present for three months (Figure 1(a) (A)). Upon palpation, the lesion was surprisingly soft and displayed dermatoscopically some inconspicuous telangiectasias with white streaks in its raised border (Figure 1(a) (B)). CISH (chromogenic in situ hybridization) was positive in a variety of B-lymphocytes, and polymerase chain reaction (PCR) showed the presence of a monoclonal immunoglobulin kappa light chain gene and immunoglobulin heavy chain (Figures 1(b) and 1(c)). Clinicopathological correlation resulted in the diagnosis of an EBV-positive mucocutaneous ulcer (EBVMCU).