case_images: PMC10930033_01
case_images: CT scans of the thorax on the day of admission demonstrates multiple nodular and patchy infiltrates in the lungs. Nodular infiltrate in the right lung (red arrows). Nodular infiltrate in the left lung (green arrows). Patchy infiltrates in both lungs (blue arrows).
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case_images: fig1
case_images: CT scans of the patient's lungs on admission revealed multiple lung nodules and patchy infiltrations (Figure 1).
case_images: Timeline of treatment process.
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case_images: fig2
case_images: The sequence of relevant events after the patient was admitted has been shown in the timeline (Figure 2).
case_images: Diagnosis of Legionella pneumophila infection using mNGS. The horizontal axis (abscissa) represents the genome of the Legionella bacterium and the vertical axis (ordinate) represents the number of reads detected. The red line indicates the coverage, which represents the ratio of the detected nucleic acid sequence of Legionella to the entire gene sequence of Legionella. The blue line represents the sequencing depth, which is a measure of how many times a specific segment of the Legionella genome has been detected during the sequencing process.
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case_images: fig3
case_images: Medicine and Innovative Drug Development & Jiangsu Simcere Diagnostics Co., Ltd. previously published paper. The mNGS results on the 5th day after admission showed that 17,667 original sequences of Legionella pneumophila were identified, with a relative abundance of 98.3% and a coverage of 7.22% (Figure 3). Meanwhile, a number of other pathogens have been identified, including certain fungi and bacteria (Table 1).
case_images: The repeated CT scan conducted on the fourth day after admission showed cavitary lesions in both lungs (red arrows and green arrows). Remaining patchy infiltrate in the right lung (blue arrow).
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case_images: fig4
case_images: On the same day, a repeated CT scan revealed the presence of bilateral lung cavities (Figure 4).
case_images: A subsequent CT scan 2 weeks later showed that the cavity in the right lung had decreased in size (red arrow), while the cavity in the left lung had slightly enlarged (green arrow). However, the thickness of the walls of both cavities had diminished, and the bilateral pulmonary infiltration indicated by the blue arrows had been resolved.
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case_images: fig5
case_images: Although the cavity in the left lung was slightly enlarged, the walls of the cavity were thinner, and the infiltration from both lungs had been resolved (Figure 5).