case_images: PMC11162524_01
case_images: The lesions were observed on the intraoral mucosae: right buccal mucosa (1A), left buccal mucosa (1B), ventral tongue (1C), and dorsal tongue (1D).
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case_images: The intraoral examination revealed several lesions of the oral mucosae which are shown in Figure 1.
case_images: The outline of representative area for incisional biopsy performed by using CO
  2 laser.
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case_images: The representative area is shown in Figure 2.
case_images: Histopathological investigation showed a distinctively band-like pattern of dense infiltration of lymphohistiocytic cells.. The carbonized zone was so narrow at less than 40 microns. This did not interfere with the oral pathologist's observation of the histological sample. (3A magnification at 40x, 3B magnification at 100x).
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case_images: Upon histopathological investigation ( Figure 3), a piece of soft tissue covered by parakeratotic acanthotic stratified squamous epithelial with some foci of liquefactive degeneration of the basal cell and apoptotic keratinocytes was observed.
case_images: Three weeks after the biopsy, it was found that the tissue had a recurring lesion (arrow).
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case_images: Three weeks later, the affected area showed signs of a recurrent lesion, and the mucosal coverage was complete ( Figure 4).
case_images: Fresh preparation of photosensitizing gel.
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case_images: Using a thermoplastic gel base makes it easy to retain 10% 5-ALA photosensitizing gel on the mucosal surfaces, as shown in the pictures of the left buccal mucosa (6A) and the ventral tongue (6B).
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case_images: A fresh gel with 10% of 5-ALA was then applied to the affected area as shown in Figure 6 and left for 30 minutes.
case_images: Laser irradiation activates a photosensitizing agent in the tissue of the left buccal mucosa (7A) and the ventral tongue (7B).
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case_images: After the patient completed ten sessions of PDT and five interim sessions of PBMT, no significant OLP lesions were observed during the 12-month follow-up.. The affected areas, which are the right buccal mucosa (8A), the left buccal mucosa (8B), the ventral tongue (8C), and the dorsal tongue (8D), were examined and showed no signs of significant lesions.
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case_images: Upon completion of 10 PDT sessions, including 5 PBMT sessions in between, the patient successfully reduced lesion size and burning sensation without any clinical complications within a 12-month, as illustrated in Figure 8.