case_images: PMC11794104_01
case_images: Large 5-cm friable ulcerative rectal neuroendocrine tumor involving the anal verge and dentate line and extending to the perirectal area.
case_images: JGH3-9-e70112-g002.jpg
case_images: PMC11794104_01_JGH3-9-e70112-g002.jpg
case_images: jgh370112-fig-0001
case_images: An ulcerated and friable rectal mass involving the anal verge and dentate line and extending to the perirectal area, which was likely the source of bleeding, was noted and biopsied (Figure 1).
case_images: (A) H&E stain demonstrating infiltrative neuroendocrine carcinoma with necrosis on the top. (B) Positive CD-56 staining. (C) Patchy positive synaptophysin. (D) Negative chromogranin.
case_images: JGH3-9-e70112-g001.jpg
case_images: PMC11794104_01_JGH3-9-e70112-g001.jpg
case_images: jgh370112-fig-0002
case_images: CD56, positive p16, patchy positive Synaptophysin, and perinuclear dot staining of Pankeratin (Table 1 and Figure 2). CDX2, CK7, CK20, CD45/LCA,