case_images: PMC11825233_01
case_images: Multiple scaly erythematous plaques and patches exhibiting numerous superficial non-follicular pustules on the back and periumbilical abdominal area. The lesions are well-demarcated, with a clear distinction between affected and unaffected skin.
case_images: cureus-0017-00000077441-i01.jpg
case_images: PMC11825233_01_cureus-0017-00000077441-i01.jpg
case_images: FIG1
case_images: Physical examination revealed numerous small, non-follicular pustules within a large background of scaly erythematous and edematous patches and plaques involving the back, abdomen, chest (Figure 1), and upper and lower extremities (Figures 2-3).
case_images: Irregularly shaped erythematous plaques with a scaly pustular eruption on the dorsal aspect of the bilateral forearms and wrists.
case_images: cureus-0017-00000077441-i02.jpg
case_images: PMC11825233_01_cureus-0017-00000077441-i02.jpg
case_images: FIG2
case_images: Physical examination revealed numerous small, non-follicular pustules within a large background of scaly erythematous and edematous patches and plaques involving the back, abdomen, chest (Figure 1), and upper and lower extremities (Figures 2-3).
case_images: Erythematous scaly plaques, with overlying non-follicular pustules scattered across the thighs and legs, with some areas of confluent erythema.
case_images: cureus-0017-00000077441-i03.jpg
case_images: PMC11825233_01_cureus-0017-00000077441-i03.jpg
case_images: FIG3
case_images: Physical examination revealed numerous small, non-follicular pustules within a large background of scaly erythematous and edematous patches and plaques involving the back, abdomen, chest (Figure 1), and upper and lower extremities (Figures 2-3).
case_images: (A, B) Histopathological examination revealed subcorneal pustules with epidermal spongiosis and neutrophil infiltrate within the upper epidermis. Along with mild perivascular inflammatory infiltrate in the superficial dermis, predominantly composed of neutrophils and scattered eosinophils. The overlying stratum corneum appears disrupted in areas, consistent with pustular exanthema. (A) (H/E stain, original magnification x10), (B) (H/E stain, original magnification x20).
case_images: cureus-0017-00000077441-i04.jpg
case_images: PMC11825233_01_cureus-0017-00000077441-i04.jpg
case_images: FIG4
case_images: Histopathological examination of the biopsy specimen revealed subcorneal pustules with surrounding spongiosis and superficial perivascular inflammatory infiltrates predominantly consisting of neutrophils and eosinophils, consistent with AGEP (Figure 4).
case_images: Generalized exfoliation and marked improvement after drug discontinuation with a significant reduction in erythema and scaling. The pustules resolved completely, leaving areas of post-inflammatory hyperpigmentation and mild residual scaling on previously affected skin.
case_images: cureus-0017-00000077441-i05.jpg
case_images: PMC11825233_01_cureus-0017-00000077441-i05.jpg
case_images: FIG5
case_images: On examination, generalized exfoliation and resolution of erythema and pustules were noted in the previously affected areas, with signs of post-inflammatory hyperpigmentation indicating recovery from the recurrent AGEP (Figures 5-6).
case_images: Generalized exfoliation and marked improvement after drug discontinuation with a significant reduction in erythema and scaling. The pustules resolved completely, leaving areas of post-inflammatory hyperpigmentation and mild residual scaling on previously affected skin.
case_images: cureus-0017-00000077441-i06.jpg
case_images: PMC11825233_01_cureus-0017-00000077441-i06.jpg
case_images: FIG6
case_images: On examination, generalized exfoliation and resolution of erythema and pustules were noted in the previously affected areas, with signs of post-inflammatory hyperpigmentation indicating recovery from the recurrent AGEP (Figures 5-6).