case_images: PMC10894504_01
case_images: Image shows a depressed nasal bridge, small dysplastic ears, upward slanting of the eyes, flat face, short neck, and joint hyperflexibility
case_images: cureus-0016-00000052982-i01.jpg
case_images: PMC10894504_01_cureus-0016-00000052982-i01.jpg
case_images: FIG1
case_images: Syndromic features were noted, including a depressed nasal bridge, small dysplastic ears, upward slanting of the eyes, a single transverse palmar crease, flat face, poor moro reflex, hypotonia, short neck, and joint hyperflexibility, leading to a clinical diagnosis of Down syndrome confirmed through karyotyping (Figure 1).
case_images: PMC10894504_02
case_images: Image shows loss of flow void in the left transverse sinus, suggesting venous sinus thrombosis
case_images: cureus-0016-00000052982-i02.jpg
case_images: PMC10894504_02_cureus-0016-00000052982-i02.jpg
case_images: FIG2
case_images: A subsequent MRI at day of life 14 revealed the loss of flow void in the left transverse sinus, suggesting venous sinus thrombosis, a rare occurrence in neonates with Down syndrome (Figure 2).
case_images: PMC10894504_03