case_images: PMC9918330_01
case_images: Signet ring cell carcinoma infiltrating the bladder. Microscopic appearance using haematoxylin and eosin stain; original magnification: 100x
case_images: cureus-0015-00000033647-i01.jpg
case_images: PMC9918330_01_cureus-0015-00000033647-i01.jpg
case_images: FIG1
case_images: She underwent a bladder ultrasound, which revealed "bladder thickening and left pyelocaliceal dilatation; a transurethral resection of a 4cm lesion of the bladder fundus revealed an adenocarcinoma with signet ring cell morphology compatible with a bladder metastasis of the gastric neoplasia" (Figure 1).
case_images: PMC9918330_02
case_images: Malignant epithelial neoplastic structures of adenocarcinomas invading the bladder. Microscopic appearance using haematoxylin and eosin stain; original magnification: 100x
case_images: cureus-0015-00000033647-i02.jpg
case_images: PMC9918330_02_cureus-0015-00000033647-i02.jpg
case_images: FIG2
case_images: Biopsy of the bladder lesion revealed tissue fragments with malignant epithelial neoplasm, and an immunohistochemical profile compatible with bladder metastasis of colonic origin (Figures 2, 3): caudal-type homeobox transcription factor 2 (CDX2) +, cytokeratin (CK) 7-, CK20-, GATA binding protein 3 (GATA3), and thyroid transcription factor (TTF-1).
case_images: Immunohistochemistry revealing Caudal-type homeobox transcription factor 2 (CDX2) positive tumour cells. Original magnification: 100x
case_images: cureus-0015-00000033647-i03.jpg
case_images: PMC9918330_02_cureus-0015-00000033647-i03.jpg
case_images: FIG3
case_images: Biopsy of the bladder lesion revealed tissue fragments with malignant epithelial neoplasm, and an immunohistochemical profile compatible with bladder metastasis of colonic origin (Figures 2, 3): caudal-type homeobox transcription factor 2 (CDX2) +, cytokeratin (CK) 7-, CK20-, GATA binding protein 3 (GATA3), and thyroid transcription factor (TTF-1).
case_images: PMC9918330_03
case_images: 18F-FDG PET showing penile metastasis. FDG PET: Fluorodeoxyglucose positron emission tomography
case_images: cureus-0015-00000033647-i04.jpg
case_images: PMC9918330_03_cureus-0015-00000033647-i04.jpg
case_images: FIG4
case_images: In this context, he performed an abdominopelvic nuclear magnetic resonance (AP NMR) and an 18- fluorodeoxyglucose positron emission tomography (PET), which revealed an extensive penile mass causing obliteration of the penile urethra (Figure 4).
case_images: Malignant epithelial neoplastic structures of adenocarcinoma invading the penile structures. Microscopic appearance using haematoxylin and eosin stain; original magnification: 100x
case_images: cureus-0015-00000033647-i05.jpg
case_images: PMC9918330_03_cureus-0015-00000033647-i05.jpg
case_images: FIG5
case_images: A biopsy was performed on the penile lesion, and its histology revealed malignant epithelial neoplastic structures of adenocarcinoma with an immunohistochemical profile of CK20+, CDX2+ and CK7-, compatible with metastatic neoplasia from primitive adenocarcinomas of the colon/rectum (Figures 5, 6).
case_images: Immunohistochemistry cytokeratin 20 (CK20) positive tumour cells. Original magnification: 100x
case_images: cureus-0015-00000033647-i06.jpg
case_images: PMC9918330_03_cureus-0015-00000033647-i06.jpg
case_images: FIG6
case_images: A biopsy was performed on the penile lesion, and its histology revealed malignant epithelial neoplastic structures of adenocarcinoma with an immunohistochemical profile of CK20+, CDX2+ and CK7-, compatible with metastatic neoplasia from primitive adenocarcinomas of the colon/rectum (Figures 5, 6).