case_images: PMC10894996_01
case_images: Blood and bone marrow cytology. Peripheral blood smear (A) and bone marrow aspirate smear (B) on day 26 after first dose of lomustine showing tricytopenia and bone marrow aplasia (May-Grunwald-Giemsa stain, x40 objective, the total magnification x400).
case_images: fped-12-1339597-g001.jpg
case_images: PMC10894996_01_fped-12-1339597-g001.jpg
case_images: F1
case_images: Bone marrow aspirates and trephine biopsies were consistent with severe aplasia (Figure 1).
case_images: Numerical hematology parameters over time. Leukocyte (A), erythrocyte (B) and thrombocyte (C) counts displayed over time. Lomustine intake on days 1 to 7 was marked by striped horizontal bars. G-CSF infusions (A), packed red blood cell (PRBC) transfusions (B) and erythrocyte transfusion (C) was marked by triangles. The patient was admitted to hospital on day 24 and discharged on day 52. The most recent set of blood counts was obtained on day 219 post lomustine intake.
case_images: fped-12-1339597-g002.jpg
case_images: PMC10894996_01_fped-12-1339597-g002.jpg
case_images: F2
case_images: The platelet nadir was observed on day 24 and the leukocyte/neutrophil nadir on day 31 after the first dose of lomustine (Figure 2).