case_images: PMC10507168_01
case_images: Images of microscopic examination of a 9-month-old, neutered, male Sphynx cat with basophilia and eosinophilia. Diff-Quik x 100 (A,B); Diff-Quik x 400 (C,D). Eosinophils (arrows) and basophils (arrowheads) were identified on the feathered edges of the blood smear.
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case_images: fig1
case_images: Eosinophilia (2.50 x 109/L; reference range, 0.17-1.60) and basophilia (0.79 x 109/L; reference range, 0.01-0.30) were newly identified on manual differential counts (Figures 1A-D).
case_images: Sagittal plane ultrasound images of the small intestine (A,C) and ileum (B,D). (A) Thickening of the muscularis propria was identified in the small intestine. It was measured at 3.07 mm. (B) The thickened muscularis propria of the ileum was measured at 4.45 mm. (C) The thickness of the small intestine reduced to 2.37 mm after treatment. (D) The thickness of the muscularis propria of the ileum reduced to 2.36 mm after treatment.
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case_images: fig2
case_images: Abdominal ultrasonography revealed an overall thickening of the muscularis propria in the small intestine (Figure 2A). The wall thickness of the muscularis propria of the ileum was 4.45 mm (Figure 2B). On abdominal ultrasound, the thickening of muscularis propria of the small intestine, including the ileum, was alleviated (Figures 2C,D).
case_images: (A) Histopathology results from the surgical biopsy of the ileum. Mild to moderate diffuse lymphoplasmacytic and eosinophilic enterocolitis with collagenous enteropathy was identified. The lamina propria was mildly to moderately expanded by lymphocytes and plasma cells with multifocally mildly increased eosinophils. Hematoxylin and eosin stain, 100 x objective. (B) Histopathology results of the endoscopic biopsy. The findings were similar to the specimens obtained by the surgical biopsy. There was no overt histologic evidence of an infectious cause or neoplastic process. Hematoxylin and eosin stain, 200 x objective.
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case_images: fig3
case_images: Multiple full-thickness sections of small intestinal mucosa obtained by the surgical punch biopsy during open abdominal surgery revealed mild to moderate expansion of the lamina propria by lymphocytes and plasma cells, along with multifocally mildly increased eosinophils (Figure 3A). The endoscopic biopsy revealed a duodenum of which the lamina propria contained mildly to moderately increased numbers of eosinophils and appropriate to sometimes mildly increased numbers of plasma cells and lymphocytes (Figure 3B).
case_images: Eosinophil and basophil count measured by manual differential counting from the time when eosinophilia and basophilia were initially identified. After oral administration of PDS, the patient showed a gradual decrease in both eosinophil counts (reference range; 0.17-1.60 x 109/L) and basophil counts (reference range; 0.01-0.30 x 109/L). They returned to the reference range, and no further gastrointestinal signs were identified 8 weeks and 10 weeks after the initial treatment, respectively.
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case_images: fig4
case_images: ELT Science Corp., Chengju, Korea) at 10 mg/kg PO q12h. Eight weeks after the treatment started, the eosinophil and basophil counts returned to the normal reference range (Figure 4).