case_images: PMC10751576_01
case_images: Continuous subcutaneous glucose monitoring using the FreeStyle CGMS Sensor. Blood glucose was measured every minute and recorded every 15 minutes. During a span of 14 days (2 days are shown), hyperglycemia and euglycemia were observed most of the time with incidental hypoglycemia.
case_images: fendo-14-1297146-g001.jpg
case_images: PMC10751576_01_fendo-14-1297146-g001.jpg
case_images: f1
case_images: Continuous glucose monitoring during hospitalization showed hyperglycemia most of the time, with occasional hypoglycemic events ( Figure 1 ).
case_images: Radiology results of the patient. (A) X-ray of the left hand/wrist showed epiphyseal closure. (B) MRI of the sella turcica showed a small anterior pituitary remnant (yellow arrow), invisible pituitary stalk, and an ectopic neurohypophysis (red arrow).
case_images: fendo-14-1297146-g002.jpg
case_images: PMC10751576_01_fendo-14-1297146-g002.jpg
case_images: f2
case_images: X-ray of the left hand and wrist revealed closed epiphysis ( Figure 2A ). MRI showed small anterior pituitary, ectopic neurohypophysis and missing pituitary stalk ( Figure 2B ).
case_images: Family pedigree. IIIf and IVa carried the p.R301C mutation in the KCNJ11 gene.
case_images: fendo-14-1297146-g003.jpg
case_images: PMC10751576_01_fendo-14-1297146-g003.jpg
case_images: f3
case_images: The mutation was validated using Sanger DNA sequencing ( Figure 3 ), and the same mutation was identified in her mother.