case_images: PMC10631771_01
case_images: a AS (lower part) with CCC (upper part); H&E. x10. b AS - numerous mitotic figures in stromal component indicated by arrowheads; H&E. x10. c CCC, H&E. x20. d Napsin A immunohistochemistry in CCC, x20.
case_images: cro-2023-0016-0001-531988_F01.jpg
case_images: PMC10631771_01_cro-2023-0016-0001-531988_F01.jpg
case_images: F1
case_images: Microscopically (Fig. 1), the tumor showed a <<phyllodes-like>> architecture (Fig. 1a) with periglandular stromal condensation. Stromal cells (Fig. 1b) were spindled with low-grade atypia and increased mitotic activity (up to 10 mitosis/mm2). Only at the very top of the AS there was an approximately 1.5 cm large area of atypical glandular proliferation consisting of back-to-back lying glands covered with cells with round vesicular nuclei with 1-2 small, membrane-bound nucleoli and copious clear to slightly eosinophilic cytoplasms (Fig. 1c). Immunohistochemically, they were positive for Napsin A (Fig. 1d) and P504s, weakly for ER, negative for PR. p53 was expressed according to wild type in both components.
case_images: Tumor variants with predicted oncogenic/driver potential according to Cancer Genome Interpreter.
case_images: cro-2023-0016-0001-531988_F02.jpg
case_images: PMC10631771_01_cro-2023-0016-0001-531988_F02.jpg
case_images: F2
case_images: We found 7 identical somatic variants in the samples of both tumors, indicating that the tumors have a high probability of having the same origin (Table 1; Fig. 2). Additionally, we have identified 7 additional variants in the carcinoma component and 3 in the sarcoma component (Table 1; Fig. 2).