case_images: PMC11779989_01
case_images: Ultrasonography and cytopathology in Case 1. (a) A 13.5 x 14.1 x 9-mm ciliary body mass involving the choroid with vitreous hemorrhage on ultrasonography. Vascular pulsations were present. (b) Fine-needle aspirate of the right ciliary body mass showing a small cluster of polyhedral lesional cells with abundant cytoplasm filled with large spherical melanin granules obscuring the nuclei. The nuclei are somewhat enlarged but without prominent nucleoli. Cellular smear, original magnification x600, Papanikolaou's stain. (c) At 1-year follow-up, there was a mass versus consolidated hemorrhage that significantly decreased in size from presentation.
case_images: CRIOPM2025-5126550.001.jpg
case_images: PMC11779989_01_CRIOPM2025-5126550.001.jpg
case_images: fig1
case_images: Ultrasonography on the right eye demonstrated a 13.5 x 14.1 x 9 mm ciliary body mass with heterogeneous echogenicity involving the choroid (Figure 1(a)). Fine-needle aspiration biopsy (FNAB) of the mass was performed and demonstrated small clusters of heavily pigmented polyhedral cells with large spherical melanocytic granules and relatively uniform bland nuclei (Figure 1(b)). The tumor decreased in thickness over the next year with observation (Figure 1(c)).
case_images: PMC11779989_02
case_images: Multimodal imaging and cytopathology in Case 2. (a) Fundus photograph shows an amelanotic mass in the inferotemporal periphery with scattered retinal exudates, subretinal fluid, and overlying vitreous hemorrhage. (b) Ultrasonography of a 5.0 x 5.8-mm choroidal mass at presentation. (c) Fine-needle aspirate of the left ciliary body mass (Case 2) showing a small cluster composed of differently pigmented lesional cells with low nucleo/cytoplasmic ratio. Large spherical melanin granules obscure the nuclei of some cells. In other less pigmented cells, the nuclei are enlarged and show prominent nucleoli (atypical features). Cellular smear, original magnification x600, Papanikolaou's stain.
case_images: CRIOPM2025-5126550.002.jpg
case_images: PMC11779989_02_CRIOPM2025-5126550.002.jpg
case_images: fig2
case_images: The left eye had a vitreous hemorrhage and inferotemporal mass with accompanying hemorrhage and exudate (Figure 2(a)). Ultrasonography confirmed a 5.0 x 5.8 mm mass with high internal reflectivity and accompanying subretinal fluid (Figure 2(b)). At this point, FNAB was performed for confirmatory diagnosis and showed a melanotic lesion composed, similarly to Case 1, of single and clustered heavily pigmented polyhedral cells with large spherical melanin granules frequently obscuring the nuclei (Figure 2(c)).