case_images: PMC11090666_01
case_images: Basic continuous venovenous haemodiafiltration (CVVHDF) configuration taken from East Kent Critical Care Guidelines. CRRT fluid was added to the circuit in three locations: prefilter replacement fluid (added to patients' blood), dialysate (runs on the other side of the filter membrane to the patients' blood), and postfilter replacement fluid (added to patients' blood). The desired total effluent dose was calculated and then divided between dialysate and replacement fluid. Citrate was used for anticoagulation.
case_images: CRICC2024-2712480.001.jpg
case_images: PMC11090666_01_CRICC2024-2712480.001.jpg
case_images: fig1
case_images: On day 1 of ICU, a decision was made to start CVVHDF with one filter at a maximum effluent flow rate of 60 ml/kg/hr (see diagram in Figure 1).
case_images: PMC11090666_02
case_images: Monitoring biological parameters after initiating continuous venovenous haemodiafiltration (CVVHDF). The graph shows relative dynamic changes to pH, plasma bicarbonate, base excess, lactate, and concentrations of noradrenaline infusion after single-filter CVVHDF is started followed by dual-filter CVVHDF, and finally single-filter CVVHDF.
case_images: CRICC2024-2712480.002.jpg
case_images: PMC11090666_02_CRICC2024-2712480.002.jpg
case_images: fig2
case_images: Within 24 hours of dual filtration, successive ABGs showed improved pH and decreased lactate (shown in Figure 2).
case_images: PMC11090666_03
case_images: PMC11090666_04
case_images: PMC11090666_05