case_images: PMC4821142_01
case_images: MRI at the onset of neurological symptoms. Axial T2-weighted fluid-attenuated inversion recovery (FLAIR) shows patchy high-signal intensity PML lesions in the right cerebellar peduncle.
case_images: crn-0008-0059-g01.jpg
case_images: PMC4821142_01_crn-0008-0059-g01.jpg
case_images: F1
case_images: T2-weighted images in the right cerebellar peduncle without diffusion restriction (fig. 1). MRI angiography and a conventional cerebral angiogram showed no abnormalities of the vascular system and no signs of vasculitis. The total lymphocyte count was 800 x 106/l; there was no anemia or evidence of renal or hepatic dysfunction, and ANA and anti-dsDNA were positive, with a low concentration of complement components C3 and C4.
case_images: PMC4821142_02
case_images: PMC4821142_03
case_images: MRI 5 months later. T2-weighted FLAIR shows a progress of high-signal intensity in the pons.
case_images: crn-0008-0059-g02.jpg
case_images: PMC4821142_03_crn-0008-0059-g02.jpg
case_images: F2
case_images: At 5 months after hospital admission, the MRI showed further disease progression in the pons (fig. 2).
case_images: MRI at the terminal stage of the disease. Axial T2-weighted MRI shows periventricular high-signal intensity.
case_images: crn-0008-0059-g03.jpg
case_images: PMC4821142_03_crn-0008-0059-g03.jpg
case_images: F3
case_images: At 12 months after the initial diagnosis, a new MRI showed bilateral periventricular high-signal intensity lesions (fig. 3), and the patient died in a persistent vegetative state 1 year after the start of her disease.