case_images: PMC11410570_01
case_images: Pathological section: hypofractionated adenocarcinoma of the gastric horn, diffuse type.
case_images: fonc-14-1425572-g001.jpg
case_images: PMC11410570_01_fonc-14-1425572-g001.jpg
case_images: f1
case_images: The pathological diagnosis of endoscopic biopsy ( Figure 1 ) showed poorly differentiated adenocarcinoma of the gastric antrum.
case_images: Molecular pathology diagnosis report: (1) fluorescence microscopy is as follows, tumor heterogeneity is obvious, microscopic cancer area is visible (2) FISH results: HER2 signal dotted distribution, counted tumor cells >= 20. mean copy number of HER2 8.05; mean copy number of CEP17 signal 3.45. HER2/CEP17 ratio = 2.33 > 2.2.
case_images: fonc-14-1425572-g002.jpg
case_images: PMC11410570_01_fonc-14-1425572-g002.jpg
case_images: f2
case_images: Immunohistochemical analysis revealed positive HER2 expression ( Figure 2 ), and immunohistochemical results were negative for MLH1 and PMS2 ( Figure 3 ).
case_images: Immunohistochemistry: staining method: VENTANA fully automated immunohistochemical staining. Labeling results: MLH1 (-internal control +); MSH (+); MSH6 (+); PMS2 (-internal control +); EBER (-).
case_images: fonc-14-1425572-g003.jpg
case_images: PMC11410570_01_fonc-14-1425572-g003.jpg
case_images: f3
case_images: Immunohistochemical analysis revealed positive HER2 expression ( Figure 2 ), and immunohistochemical results were negative for MLH1 and PMS2 ( Figure 3 ).