case_images: PMC9167125_01
case_images: H&E stain (200x) showing marked canalicular cholestasis, portal and periportal fibrosis, bile duct injury, ductular reaction, and portal and lobular neutrophilic infiltrates, most suggestive of biliary obstruction.
case_images: CRIHEP2022-9630996.001.jpg
case_images: PMC9167125_01_CRIHEP2022-9630996.001.jpg
case_images: fig1
case_images: Given worsening hyperbilirubinemia, a liver biopsy was subsequently pursued which was suggestive of a nonspecific cholestatic liver injury (Figures 1-3).
case_images: H&E stain (200x) showing marked canalicular cholestasis, portal and periportal fibrosis, bile duct injury, ductular reaction, and portal and lobular neutrophilic infiltrates, most suggestive of biliary obstruction.
case_images: CRIHEP2022-9630996.002.jpg
case_images: PMC9167125_01_CRIHEP2022-9630996.002.jpg
case_images: fig2
case_images: Given worsening hyperbilirubinemia, a liver biopsy was subsequently pursued which was suggestive of a nonspecific cholestatic liver injury (Figures 1-3).
case_images: Trichrome stain (40x) showing portal and periportal fibrosis, as well as focal sinusoidal collagen deposition.
case_images: CRIHEP2022-9630996.003.jpg
case_images: PMC9167125_01_CRIHEP2022-9630996.003.jpg
case_images: fig3
case_images: Given worsening hyperbilirubinemia, a liver biopsy was subsequently pursued which was suggestive of a nonspecific cholestatic liver injury (Figures 1-3).
case_images: Total bilirubin trends with relation to initiation and discontinuation of ruxolitinib.
case_images: CRIHEP2022-9630996.004.jpg
case_images: PMC9167125_01_CRIHEP2022-9630996.004.jpg
case_images: fig4
case_images: TB to 17 mg/dL (Figure 4). The patient's course was unfortunately complicated by renal failure secondary to biopsy-confirmed bile-acid nephropathy, ascites, functional decline, and eventually was transitioned to hospice.