case_images: PMC6261234_01
case_images: Merkel cell carcinoma skin lesion.
case_images: CRIONM2018-1736854.001.jpg
case_images: PMC6261234_01_CRIONM2018-1736854.001.jpg
case_images: fig1
case_images: Fried egg appearance; bone marrow trephine (H&E stain).
case_images: CRIONM2018-1736854.002.jpg
case_images: PMC6261234_01_CRIONM2018-1736854.002.jpg
case_images: fig2
case_images: The bone marrow trephine demonstrated a "fried egg appearance," a morphological feature considered highly suggestive of HCL (Figure 2).
case_images: Merkel cell infiltration of bone marrow trephine (H&E stain).
case_images: CRIONM2018-1736854.003.jpg
case_images: PMC6261234_01_CRIONM2018-1736854.003.jpg
case_images: fig3
case_images: Bone marrow trephine also showed large nonhaematopoietic tumor cells appearing to grow in organoid formation suggestive of an undifferentiated carcinoma (Figure 3).
case_images: Chromogranin staining Merkel cells in BM trephine.
case_images: CRIONM2018-1736854.004.jpg
case_images: PMC6261234_01_CRIONM2018-1736854.004.jpg
case_images: fig4
case_images: Immunohistochemical stains were positive for cytokeratin-20 (CK-20), chromogranin A (Figure 4) and synaptophysin and negative for CD45, CD20, and cytokeratin-7 (CK-7).
case_images: (a, b) Hairy cells in the peripheral blood H&E stain.
case_images: CRIONM2018-1736854.005.jpg
case_images: PMC6261234_01_CRIONM2018-1736854.005.jpg
case_images: fig5
case_images: The characteristic cytoplasmic hairy projections of the lymphoid cells are demonstrated in Figures 5(a) and 5(b).