case_images: PMC10999639_01
case_images: Chest contrast-enhanced computed tomography images revealed a 4.0*4.4 cm right lower lobe lung mass, in (A) lung window and (B) mediastinal window. Pathologic and immunohistochemical findings in lung cancer with choriocarcinoma features. (C) H&E staining of lung tumor. (D) H&E staining of metastatic lymph node(11R). Lymph node(11R) showed positive staining for (E) CK7 and (F) beta-hCG.
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case_images: However, CT scan of the chest revealed a 4.0 x 4.4 cm opacity in the right lower lobe ( Figures 1A, B ), leading to an EBUS for the biopsy of the lung mass and mediastinal nodes. CK7 and beta-hCG staining were positive and the tumor had morphologic features like the brain lesion ( Figures 1C-F ).
case_images: (A) The prevalence of cancer types based on the tumor's molecular signature, including all the mutations (Data from Caris). (B) Phylogenetic tree of lung cancer with choriocarcinoma features. (C) Timeline of the patient's diagnosis and treatments.
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case_images: Additionally, a cancer-type similarity assessment that compared patient's tumor against the signatures across 21 distinct common cancer types in the Caris database revealed that the most likely cancer type was lung adenocarcinoma ( Figure 2A ).