case_images: PMC5994559_01
case_images: Magnetic resonance imaging demonstrating multiple contrast-enhanced nodular masses along the leptomeninges of cervical (A1), thoracic (A2), and brain (A3) region at admission and progress in all three regions after 3 weeks (B1-B3). Arrows indicate leptomeningeal enhancement with multiple nodular lesions. Chest computed tomography (C) at admission revealed patchy areas of consolidation and cavitation primary in the left upper lung lobe (arrow). (D,E) show the respiratory burst capability of neutrophils. 100 microl of heparinized whole blood of the patient (red histograms) and a healthy control (gray histograms) was stimulated with Escherichia coli
  (D) and phorbol-myristate acetate (E) in a 37 C water bath for 10 min. After adding DHR123, samples were incubated for another 10 min. Finally, the red blood cells were lysed, and the washed samples were subjected to flow cytometry analysis. Histopathological examination (hematoxylin and eosin stain) shows granulomas as indicated by arrows in the lung tissue obtained by surgical biopsy in 2007 (F,H) and obtained by bronchoscopy in 2016 (G,I).
case_images: fimmu-09-01258-g001.jpg
case_images: PMC5994559_02_fimmu-09-01258-g001.jpg
case_images: F1
case_images: Histological assessment revealed similar patterns of granulomas (Figures 1F-H). The analyses revealed a complete loss of intracellular hydrogen peroxide production (Figures 1D,E), which was consistent with the diagnosis of CGD. Spinal MRI 3 weeks after admission exhibited further progress of the nodular masses (Figures 1B1,B2). Brain edema regressed but MRI of the brain showed signs of brainstem meningitis and ventriculitis (Figure 1B3).
case_images: PMC5994559_02
case_images: Magnetic resonance imaging demonstrating multiple contrast-enhanced nodular masses along the leptomeninges of cervical (A1), thoracic (A2), and brain (A3) region at admission and progress in all three regions after 3 weeks (B1-B3). Arrows indicate leptomeningeal enhancement with multiple nodular lesions. Chest computed tomography (C) at admission revealed patchy areas of consolidation and cavitation primary in the left upper lung lobe (arrow). (D,E) show the respiratory burst capability of neutrophils. 100 microl of heparinized whole blood of the patient (red histograms) and a healthy control (gray histograms) was stimulated with Escherichia coli
  (D) and phorbol-myristate acetate (E) in a 37 C water bath for 10 min. After adding DHR123, samples were incubated for another 10 min. Finally, the red blood cells were lysed, and the washed samples were subjected to flow cytometry analysis. Histopathological examination (hematoxylin and eosin stain) shows granulomas as indicated by arrows in the lung tissue obtained by surgical biopsy in 2007 (F,H) and obtained by bronchoscopy in 2016 (G,I).
case_images: fimmu-09-01258-g001.jpg
case_images: PMC5994559_02_fimmu-09-01258-g001.jpg
case_images: F1
case_images: Histological assessment revealed similar patterns of granulomas (Figures 1F-H). The analyses revealed a complete loss of intracellular hydrogen peroxide production (Figures 1D,E), which was consistent with the diagnosis of CGD. Spinal MRI 3 weeks after admission exhibited further progress of the nodular masses (Figures 1B1,B2). Brain edema regressed but MRI of the brain showed signs of brainstem meningitis and ventriculitis (Figure 1B3).