case_images: PMC10049844_01
case_images: Huge thymic tumor with superior vena cava infiltration on CECT-TAP in 2013 (prior surgery).
case_images: CRIS2023-3114843.001.jpg
case_images: PMC10049844_01_CRIS2023-3114843.001.jpg
case_images: fig1
case_images: A 61-year-old woman with a history of malignant thymoma was diagnosed in year 2013 with superior vena cava involvement (Masaoka-Koga staging III) (Figure 1).
case_images: No evidence of breast lesion seen on CECT-TAP in 2016.
case_images: CRIS2023-3114843.002.jpg
case_images: PMC10049844_01_CRIS2023-3114843.002.jpg
case_images: fig2
case_images: Three years after the surgery, surveillance imaging with contrast enhanced computed tomography (CECT) thorax showed increased lung nodules suspicious of metastasis in 2016 (Figure 2).
case_images: Mammogram of right breast showed well-circumscribed, round, high-density lesions at upper mid region and upper outer quadrants.
case_images: CRIS2023-3114843.003.jpg
case_images: PMC10049844_01_CRIS2023-3114843.003.jpg
case_images: fig3
case_images: Mammogram of bilateral breasts showed well-circumscribed, round, high-density lesions at upper mid region and upper outer quadrant of right breast (Figure 3).
case_images: On histology, the lesional tissue is composed of (a) and (b) tumour tissue arranged in anastomosing smooth contoured islands, Hematoxylin & Eosin stain (H&E) x40. (c) Absence of duct/glandular formation, H&E x100. (d) Tumour cells have round to oval nuclei, inconspicuous nucleoli, and indistinct cell membrane, H&E x400.
case_images: CRIS2023-3114843.004.jpg
case_images: PMC10049844_01_CRIS2023-3114843.004.jpg
case_images: fig4
case_images: Tissue core-biopsy of right breast 12 o'clock lump was performed, and histopathology examination came back as metastatic thymic carcinoma (Figure 4), p53, and CD5 positive for staining (Figure 5).
case_images: (a) Tumour cells show positive staining for p63 (x40). (b) CD5 shows patchy positive cells (x40).
case_images: CRIS2023-3114843.005.jpg
case_images: PMC10049844_01_CRIS2023-3114843.005.jpg
case_images: fig5
case_images: Tissue core-biopsy of right breast 12 o'clock lump was performed, and histopathology examination came back as metastatic thymic carcinoma (Figure 4), p53, and CD5 positive for staining (Figure 5).