case_images: PMC11180752_01
case_images: The clinical course and peripheral blood counts of the case. The horizontal axis shows the time course of this case, with one scale representing 1 year. Hb, Hemoglobin; Plt, Platelet count; ANC, Absolute neutrophil count;  : Beyond the normal upper limit. RP: The patient got complete remission after DE 2 cycles; but she was relapsed after the fourth cycle.
case_images: fimmu-15-1391074-g001.jpg
case_images: PMC11180752_01_fimmu-15-1391074-g001.jpg
case_images: f1
case_images: The clinical course of our case is shown in  Figure 1 . Fibrinogen content (Fib):1.93 g/L, Virus series examination showed EBV-DNA level of 5.01 x 104 IU/mL, Soluble CD25 > 44000 U/ml, NK cell activity of 7.45%, and MUNC13-4 (UNC13D) expression report suggested it was lower than that in normal control, which was shown in  Figure 2  and  Table 1 .
case_images: Flow Cytometry Analysis Report of MUNC13-4 (UNC13D) Expression. The upper part of the picture showed the negative marker of MUNC13-4 expression was determined by the Isotype control. The below part of the pictures show that MUNC13-4 was detected in the patient's sample, the gate P2 represented the positive part of MUNC13-4 expression. Positive specific MUNC13-4 expression is defined as the P2 portion of the patient sample minus the isotype-labeled portion (the top half of the picture) over the Marker's non-specific positive expression. The specific relationship is shown in 
  Table 1
  . NK, NK cell; CTL, Cytotoxic T Lymphocyte.
case_images: fimmu-15-1391074-g002.jpg
case_images: PMC11180752_01_fimmu-15-1391074-g002.jpg
case_images: f2
case_images: Fibrinogen content (Fib):1.93 g/L, Virus series examination showed EBV-DNA level of 5.01 x 104 IU/mL, Soluble CD25 > 44000 U/ml, NK cell activity of 7.45%, and MUNC13-4 (UNC13D) expression report suggested it was lower than that in normal control, which was shown in  Figure 2  and  Table 1 .
case_images: Multiple patchy T2 hyper-intensities were observed in the subcortical and deep white matter of both cerebral hemispheres, partially located around the ventricles. Similar lesions were also observed in the bilateral cerebellar hemispheres under the tentorium. Head magnetic resonance imaging shows multiple patchy hyper-intensities in the Flair images, which were located in the bilateral frontal (blue arrow), deep bilateral parietal (red arrow), sub-insular cortex (yellow arrow), and periventricular white matter (green arrow).
case_images: fimmu-15-1391074-g003.jpg
case_images: PMC11180752_01_fimmu-15-1391074-g003.jpg
case_images: f3
case_images: Brain MR showed white matter damage, as depicted in  Figure 3 .