case_images: PMC8375471_01
case_images: Fetal sonographic findings at 31 gestation in the NIHF case with PIEZO1 mutations: (A) Bilateral pleural effusion on axial view. (B) Skin edema on axial view. (C) Peritoneal effusion on axial view. (D) Pedigree of the family. The affected fetus is marked in black.
case_images: fgene-12-684555-g0001.jpg
case_images: PMC8375471_01_fgene-12-684555-g0001.jpg
case_images: F1
case_images: At 31 weeks gestation, a thorough fetal systematic ultrasound was performed by prenatal diagnostic ultrasound specialists and showed massive bilateral pleural effusion, generalized skin edema (skin thickness of head and neck region was 18 mm), minor ascites, and polyhydramnios (amniotic fluid index was 28.5 cm) (Figures 1A-C).