case_images: PMC11289518_01
case_images: At the time of the MM diagnosis, the bone marrow was as above. (A) x10 magnification; (B) x100 magnification.
case_images: JBM-15-325-g0001.jpg
case_images: PMC11289518_01_JBM-15-325-g0001.jpg
case_images: f0001
case_images: Bone marrow smear revealed 5.2% primary plasma cells (Figure 1).
case_images: Bone marrow biopsy Immunohistochemistry: CD34 small vessel (+), occasional (+); CD11+ 17 occasional (+); CD61 megakaryocytes (+), sporadic (+); CD3 less (+); CD138 small cluster (+); MPO multiple (+); E-cad multicluster (+).
case_images: JBM-15-325-g0002.jpg
case_images: PMC11289518_01_JBM-15-325-g0002.jpg
case_images: f0002
case_images: Inc). Bone marrow biopsy suggested the hyperplasia of nucleated cells in bone marrow is roughly normal (about 40% hematopoietic area); the granule/red ratio is roughly normal (Figure 2). Immunohistochemistry is shown
case_images: FISH: 1q21/1p32 (a), 13q14.3/(b), and 13q34 RB1(13q14) (c) genes are positive.
case_images: JBM-15-325-g0003.jpg
case_images: PMC11289518_01_JBM-15-325-g0003.jpg
case_images: f0003
case_images: CD138 (+), MPO (+), E-cad multicluster (+). Cytogenetic analysis revealed a normal female karyotype of 46 XX, while the mutation gene suggest that 1q21/1p32 13q14.3/13q34 RB1(13q14) genes are positive (Figure 3).