case_images: PMC11814853_01
case_images: Cytogenetic analysis. A. G-banded metaphase analysis showed a 47,X,i(X)(q10),Y karyotype.
  B. Fluorescently labeled DNA probes hybridized to metaphase and interphase cells revealed the presence of four red signals (denoted by red arrows) for the VAMP7 gene (350 kb), located on the PAR2 region of the long arm of the X chromosome and the q arm of the Y chromosome, indicating partial trisomy of Xq28. Additionally, one green signal (denoted by a green arrow) for the DYZ3 region, located near the centromere of the Y chromosome, indicates the presence of the Y chromosome.. PAR: pseudoautosomal region
case_images: cureus-0017-00000077351-i01.jpg
case_images: PMC11814853_01_cureus-0017-00000077351-i01.jpg
case_images: FIG1
case_images: Karyotyping analysis consistently revealed 47,X,i(X)(q10),Y karyotypes in all examined metaphases (Figure 1A). Additionally, one red signal was detected on chromosome Y (q12) for the VAMP7 (350 kb) gene of the PAR2 region, and one green signal was observed for the DYZ3 region located near the centromere of chromosome Y (Figure 1B).