case_images: PMC6083738_01
case_images: Torso positron emission tomography-computed tomography scan demonstrated no abnormal FDG uptake.
case_images: CRIE2018-7676580.001.jpg
case_images: PMC6083738_01_CRIE2018-7676580.001.jpg
case_images: fig1
case_images: A torso positron emission tomography-computed tomography (PET-CT) scan also showed no abnormal FDG uptake (Figure 1).
case_images: Histopathology of bone marrow biopsy specimen. (a) Bone marrow biopsy (hematoxylin-eosin stain, x200) shows infiltration of large atypical cells. (b) The immunohistochemical staining for CD20 (x100) is diffusely positive in large atypical cells.
case_images: CRIE2018-7676580.002.jpg
case_images: PMC6083738_01_CRIE2018-7676580.002.jpg
case_images: fig2
case_images: Immunophenotyping of bone marrow cells further supported the diagnosis of BCL, with the population testing positive for CD45, CD19, CD20, CD79a, and HLA-DR (Figures 2 and 3); however, terminal deoxynucleotidyl transferase expression in bone marrow cells was negative.
case_images: Bone marrow aspiration (Wright-Giemsa stain, x1000) shows infiltration of diffuse large B-cell lymphoma. Large, atypical cells with irregularly shaped nuclei and basophilic cytoplasm are noted in clusters.
case_images: CRIE2018-7676580.003.jpg
case_images: PMC6083738_01_CRIE2018-7676580.003.jpg
case_images: fig3
case_images: Immunophenotyping of bone marrow cells further supported the diagnosis of BCL, with the population testing positive for CD45, CD19, CD20, CD79a, and HLA-DR (Figures 2 and 3); however, terminal deoxynucleotidyl transferase expression in bone marrow cells was negative.