case_images: PMC11177606_01
case_images: H&E staining and immunohistochemistry of excised tumors. Scale bars for 2011 and 2014 = 10 microm. Scale bars for 2018 and 2020 = 50 microm.
case_images: fonc-14-1392610-g001.jpg
case_images: PMC11177606_01_fonc-14-1392610-g001.jpg
case_images: f1
case_images: The nuclei of these cells showed mild atypia; no mitotic figures or necrosis was identified ( Figure 1 ). Positivity of Syn, CD56, Ki-67 (8%), and CK were also found ( Figure 1 ), while S-100, CK5/6, and CK7 were each negative. Via immunohistochemistry Syn, CD56, Ki-67 (about 5%), CK, and P63 were detected, while results for CK20 and GFAP were negative ( Figure 1 ).
case_images: MRI images of the middle ear and brain. In 2014 (A, D, G, J), irregular soft tissue signal shadows in the right external auditory canal, middle ear cavity, and mastoid cells are shown. In 2018 (B, E, H, K), an irregular mass (14 x 18 x 12 mm) in the right external auditory canal and middle ear cavity and tumor invasion into the brain is presented. In 2020 (C, F, I, L), tumor metastases in the right cerebellopontine angle and right temporal meningeal.
case_images: fonc-14-1392610-g002.jpg
case_images: PMC11177606_01_fonc-14-1392610-g002.jpg
case_images: f2
case_images: Magnetic resonance imaging (MRI) showed tumors and bleeding in the right external ear canal, middle ear cavity, and mastoid cells ( Figure 2 ). Tumor invasion of the right temporal lobe and meninges was found ( Figure 2 ). MRI examination suggested new tumor metastases in the right cerebellopontine angle and right temporal meningeal as well as residual tumor in the operative region ( Figure 2 ).