case_images: PMC7711105_01
case_images: PMC7711105_02
case_images: (A) G-banding analysis of case 2 showed t(14;19) accompanied by a complex.karyotype of near-tetraploid with concurrent 6q deletion and +12. (B) Interphase FISH analysis of case 2 using the dual-color BCL3 probe. FISH results demonstrated two intact red/green fusion signals, and 2 red and 2 green split signals, which indicated BCL3 gene break-apart. (Yellow arrows pointed to split signals of the rearranged gene).
case_images: fonc-10-594732-g001.jpg
case_images: PMC7711105_02_fonc-10-594732-g001.jpg
case_images: f1
case_images: G-banding analysis showed a complex karyotype of near-tetraploid: 85~90, XXYY, del(6)(q21), -7, -8, -10, +12, -13, t(14;19)(q32;q13)x2, -15, -18[cp10] ( Figure 1A ), and a concurrent 6q deletion and trisomy 12 in addition to t(14;19), which were all confirmed by FISH ( Figure 1B ).
case_images: PMC7711105_03