case_images: PMC10408311_01
case_images: Computed tomography of the maxillofacial region showed a well-defined 25 mm x 16 mm osteolytic lesion involving the right mandible.
case_images: 10.1177_2050313X231192752-fig1.jpg
case_images: PMC10408311_01_10.1177_2050313X231192752-fig1.jpg
case_images: fig1-2050313X231192752
case_images: Computed tomography of the maxillofacial region showed a well-defined 25 mm x 16 mm osteolytic lesion affecting the right mandible; erosion of the cortex was present (Figure 1).
case_images: Gross specimen showed bundles of spindle-shaped fibroblasts as well as foam cells (hematoxylin and eosin, x100).
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case_images: PMC10408311_01_10.1177_2050313X231192752-fig2.jpg
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case_images: The gross specimen of the lesion showed whorled bundles of spindle-shaped fibroblasts (Figure 2), as well as foam cells, mingled with scant multinucleated giant cells, without any bone formation in the lesion.
case_images: Strongly and diffusely positive staining for SATB2 by immunohistochemistry (Envison, x200).
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case_images: PMC10408311_01_10.1177_2050313X231192752-fig3.jpg
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case_images: The lesion showed strongly and diffusely positive staining for SATB2 (Special AT-rich sequence binding protein 2) (Figure 3), focal positive for SMA (Anti-smooth muscle antibody), KP1 (Anti-CD 68 antibody), and ER (Estrogen Receptor) (Figure 4), and negative for H3.3G34W by immunohistochemistry.
case_images: ER expressed in the NOF (Envision, x400).. NOF: non-ossifying fibroma.
case_images: 10.1177_2050313X231192752-fig4.jpg
case_images: PMC10408311_01_10.1177_2050313X231192752-fig4.jpg
case_images: fig4-2050313X231192752
case_images: The lesion showed strongly and diffusely positive staining for SATB2 (Special AT-rich sequence binding protein 2) (Figure 3), focal positive for SMA (Anti-smooth muscle antibody), KP1 (Anti-CD 68 antibody), and ER (Estrogen Receptor) (Figure 4), and negative for H3.3G34W by immunohistochemistry.
case_images: USP6 break-apart fluorescence in situ hybridization.
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case_images: PMC10408311_01_10.1177_2050313X231192752-fig5.jpg
case_images: fig5-2050313X231192752
case_images: With respect to USP6 (Ubiquitin-specific proteases) break-apart fluorescence in situ hybridization, the result was negative (Figure 5).