case_images: PMC11790801_01
case_images: Lesions of palmoplantar pustulosis on both feet prior to treatment (A and B), one month following a single intralesional treatment with spesolimab (C and D), and two months after treatment (E and F).
case_images: IMCRJ-18-205-g0001.jpg
case_images: PMC11790801_01_IMCRJ-18-205-g0001.jpg
case_images: f0001
case_images: Physical examination revealed pustules and eczematous hyperkeratotic scaly plaques on both soles with no involvement of the palms (Figure 1A and B). On 20 May 2024, the lesions showed dramatic improvement (Figure 1C and D), as evidenced by PPP ASI and PPP PGA scores of 1.2 and 1, respectively, indicating that the patient achieved PPP ASI75 (defined as >= 75% reduction from baseline PPP ASI). On 9 July 2024, the patient's PPP ASI and PPP PGA scores were 0.6 and 0, respectively, reflecting the achievement of PPP ASI90 (Figure 1E and F).