case_images: PMC11793844_01
case_images: Enlarged bilateral cervical lymph nodes upon admission . This highlights the initial clinical feature before the progression of the disease.
case_images: cureus-0017-00000076934-i01.jpg
case_images: PMC11793844_01_cureus-0017-00000076934-i01.jpg
case_images: FIG1
case_images: However, one week following the procedure, the patient noted the appearance of a new mass in the right mandibular area (Figure 1).
case_images: Histological sections of the excised lymph node demonstrating increased volume. (a) Histiocyte exhibiting emperipolesis with numerous engulfed lymphocytes; (b) Immunohistochemical staining highlighting strong S100 protein expression; (c) Immunohistochemical staining highlighting strong CD163 expression.
case_images: cureus-0017-00000076934-i02.jpg
case_images: PMC11793844_01_cureus-0017-00000076934-i02.jpg
case_images: FIG2
case_images: Immunohistochemical analysis revealed that these cells were positive for CD163 and S-100 protein, and negative for CD1a, which confirmed the diagnosis of Rosai-Dorfman-Destombes disease (Figure 2).