case_images: PMC8077407_01
case_images: Histopathological examination of the primary leptomeningeal glioblastoma. a Prominent tumor cell infiltrate in the subarachnoid space and reactive astrogliosis in the brain parenchyma. x20. Hematoxylin and eosin. b The astrocytic tumor cells are positive for glial fibrillary acid protein. x40. c Nearly all tumor cells are positive for the oncoprotein p53. x10. d The p53-positive tumor cells are spreading through the Virchow-Robin spaces throughout the brain. x40.
case_images: crn-0013-0179-g01.jpg
case_images: PMC8077407_01_crn-0013-0179-g01.jpg
case_images: F1
case_images: A diffuse, malignant, astrocytically differentiated leptomeningeal glioma was found in the overlying meninges, compatible with a primary leptomeningeal glioblastoma of a diffuse type (WHO grade IV, IDH wild type) with tumor infiltration of the cerebral parenchyma and the cerebellar cortex (Fig. 1).