case_images: PMC11824303_01
case_images: MRI showing hypersignal lesions (arrows) in the thalami on axial FLAIR (a) and T2-weighted (b) sequences.
case_images: CRICC2025-7607058.001.jpg
case_images: PMC11824303_01_CRICC2025-7607058.001.jpg
case_images: fig1
case_images: In regard to the cases with positive MRI findings, typical encephalic involvement was identified as bilateral and symmetrical hypersignal in the following regions: The thalamic region was affected in 87.5% (7/8) (Figure 1), periaqueductal region mammillary bodies in 71.4% (5/7), and third ventricle in 37.5% (3/8), while atypical lesions were as follows: centrum semiovale, tectal plate, and the frontal lobe in 25% (2/8) and brainstem, corpus callosum, red nuclei, and cerebellum in 12.5% (1/8) (Figure 2).
case_images: MRI of patients showing hypersignal lesions (arrows) on axial FLAIR in (a) the brainstem; (b) central pons and cerebellum; (c) red nuclei; (d) tectal plate; (e) mammillary bodies and periaqueductal region; (f) wall of the third ventricle; (g) thalami, paraventricular region, and frontal lobe; and (h) centrum semiovale.
case_images: CRICC2025-7607058.002.jpg
case_images: PMC11824303_01_CRICC2025-7607058.002.jpg
case_images: fig2
case_images: In regard to the cases with positive MRI findings, typical encephalic involvement was identified as bilateral and symmetrical hypersignal in the following regions: The thalamic region was affected in 87.5% (7/8) (Figure 1), periaqueductal region mammillary bodies in 71.4% (5/7), and third ventricle in 37.5% (3/8), while atypical lesions were as follows: centrum semiovale, tectal plate, and the frontal lobe in 25% (2/8) and brainstem, corpus callosum, red nuclei, and cerebellum in 12.5% (1/8) (Figure 2).