case_images: PMC11392889_01
case_images: (A) axial lung window, CT showed multiple polypoid lesions in the middle bronchus of the right lung; (B) axial bone window; (C) coronal scan; (D) saggital scan.
case_images: fonc-14-1431950-g001.jpg
case_images: PMC11392889_01_fonc-14-1431950-g001.jpg
case_images: f1
case_images: Computed tomography (CT) performed at another hospital detected multiple polypoid lesions in the middle bronchus of the right lung, the largest measuring approximately 0.7 cmx0.7 cmx0.6 cm ( Figure 1 ).
case_images: (A) Bronchoscopic images demonstrated polypoid endobronchial tumors that originated in the middle bronchus of the right lung. (B) The tumor cells show small, round-to-oval nuclei without rosette-like arrangement (HE, original magnification 200). (C-E) Immunohistochemical findings showed strongly positivity for CD99, NKX2.2 and CD56 (F) The Ki-67 labeling index was approximately 50%.
case_images: fonc-14-1431950-g002.jpg
case_images: PMC11392889_01_fonc-14-1431950-g002.jpg
case_images: f2
case_images: The lesions partially obstructed the middle bronchus with no evidence of invasion ( Figure 2A ). Hematoxylin and eosin (H&E) staining revealed monomorphic population of small blue cells with variably conspicuous nucleoli and scant cytoplasm ( Figure 2B ). Immunohistochemistry analysis demonstrated strong positivity for CD99, NKX2.2, CD56, P63, INI-1, and negativity for PCK, Syn, CgA, EMA, DSE, Myogenin, S100, SMA, WT-1, LCA, CK8/18 ( Figures 2C-E ). Figure 2F ). Fluorescence in situ hybridization (FISH) for