case_images: PMC3589216_01
case_images: Notably increased corneal thickness accompanied by severe subepithelial and anterior stromal fibrosis (F), foci of neovascularization with intra-stromal inflammation and severe loss of corneal endothelial cells (hematoxylin & eosin staining, x40).
case_images: JOVR-3-66f1.jpg
case_images: PMC3589216_01_JOVR-3-66f1.jpg
case_images: f1-jovr-3-66
case_images: Light microscopy of H&E stained sections revealed corneal thickness to about 2 mm (Fig. 1), irregular and somehow thinned epithelium with basal and subepithelial bullous changes (Fig. 2-A). The Descemet membrane had apparently normal thickness, however endothelial cell count was severely reduced (Fig. 1).
case_images: (A) Bullous changes in the basal epithelial cells (hematoxylin & eosin staining, x400); (B) Neovascularization foci with chronic granulomatous inflammation and intra-stromal cholesterol clefts (hematoxylin & eosin staining, x200).
case_images: JOVR-3-66f2.jpg
case_images: PMC3589216_01_JOVR-3-66f2.jpg
case_images: f2-jovr-3-66
case_images: Extensive foci of stromal neovascularization accompanied by chronic granulomatous inflammation (Fig. 2-B) with giant multinuclear cells (Fig. 3-A) surrounding intrastromal cholesterol clefts (Fig. 3-B) were seen.
case_images: (A) Multinuclear giant cells (G) in lipogranulomatous reaction of the stroma and foci of neovascularization (hematoxylin & eosin staining, x400); (B) Intra-stromal cholesterol clefts (C) and lipogranulomatous reactions (hematoxylin & eosin staining, x200).
case_images: JOVR-3-66f3.jpg
case_images: PMC3589216_01_JOVR-3-66f3.jpg
case_images: f3-jovr-3-66
case_images: Extensive foci of stromal neovascularization accompanied by chronic granulomatous inflammation (Fig. 2-B) with giant multinuclear cells (Fig. 3-A) surrounding intrastromal cholesterol clefts (Fig. 3-B) were seen.