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case_images: Hyperechoic tumor formation in the abdomen of the fetus, size 50 x 50 mm.
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case_images: A tumor-like hyperechoic formation in the fetal abdomen, measuring 52.53 x 55.36 mm, was noted but could not be reliably identified (Figure 1).
case_images: Gross autopsy findings of the abdominal cavity and the right kidney. (A) Enlarged right kidney compresses abdominal organs (liver and intestinal tract); (B) Cross-section of the right kidney illustrates tumor mass which completely replaced the normal kidney parenchyma.
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case_images: On cross-section, the tissue exhibited a yellowish color interspersed with darker brownish areas (Figure 2).
case_images: Pathohistology of congenital mesoblastic nephroma. (A,B) The tumor was composed of uniform spindle cells arranged in clusters and fascicles, with indistinct intercellular boundaries, trapping small islands of non-neoplastic renal tissue (HE stain); immunohistochemically, the tumor cells exhibited diffuse (C) vimentin and (F) INI1 positivity along with focal positivity for (D) WT1, and (E) cyclin D1. The tumor cells were negative for (G) SMA (internal positive control are blood vessels), (H) CD34 (internal positive control are blood vessels), (I) bcl-2, (J) ALK, and (K) BCOR.
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case_images: The tumor lacked a capsule, and the tumor-kidney border appeared irregular, with small islands of entrapped non-neoplastic renal tissue (Figure 3). The lack of features characteristic of the other entities considered supports the final diagnosis (Figure 3).
case_images: Gross autopsy findings of the brain. (A) Antero-posterior view of left and right cerebral hemispheres revealed abnormal cortical folding, predominantly of the lissencephalic type; (B) Temporal-parietal view of the right cerebral hemisphere revealed abnormal cortical folding, predominantly of the lissencephalic type, although the possibility of pachygyria cannot be completely ruled out with certainty; (C) Coronal planes of brain sections revealed massive intraventricular bleeding.
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case_images: Furthermore, the gross morphological findings suggested an anomaly in cerebral cortical folding, predominantly of the lissencephalic type (absence of gyri in the large brain), as illustrated in Figure 4, although the possibility of pachygyria (presence of a small number of wide gyri and identified presence of four sulci) could not be completely ruled out with certainty.
case_images: Pathohistology of the brain and lung sections. (A) The absence of large brain gyri; thus, the brain surface was almost completely flat; (B) Occasional rudimentary sulci of the large brain cortex. (C,D) Well-developed periventricular germinal matrix with pronounced fresh hemorrhages; (E) Diffuse and thick intraalveolar hyaline membranes illustrated the morphology of severe diffuse alveolar damage.
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case_images: The histopathological finding in the lungs indicated diffuse alveolar damage (Figure 5).