case_images: PMC3843903_01
case_images: Submandibular mass biopsy revealing florid follicular hyperplasia along with eosinophilic cell infiltration, focal fibrosis and giant cell reaction.
case_images: crg-0007-0476-g01.jpg
case_images: PMC3843903_01_crg-0007-0476-g01.jpg
case_images: F1
case_images: The patient underwent biopsy of the submandibular mass that revealed features of Castleman's disease (fig. 1).
case_images: Liver biopsy revealing perisinusoidal deposition of eosinophilic, amorphous material within the extracellular matrix with hepatocyte atrophy, consistent with hepatic amyloidosis.
case_images: crg-0007-0476-g02.jpg
case_images: PMC3843903_01_crg-0007-0476-g02.jpg
case_images: F2
case_images: A subsequent liver biopsy revealed perisinusoidal deposition of eosinophilic, amorphous material within the extracellular matrix with hepatocyte atrophy, consistent with hepatic amyloidosis (fig. 2).
case_images: Bone marrow biopsy revealing diffuse extracellular eosinophilic, amorphous material consistent with amyloidosis.
case_images: crg-0007-0476-g03.jpg
case_images: PMC3843903_01_crg-0007-0476-g03.jpg
case_images: F3
case_images: Bone marrow biopsy revealed diffuse extracellular eosinophilic, amorphous material consistent with amyloidosis with increased kappa light chain-restricted plasma cell count (6% of hematopoietic bone marrow cells) (fig. 3).