case_images: PMC11085031_01
case_images: Light microscopy. The sample contained 21 glomeruli and fourteen (67%) showed global sclerosis. All the glomeruli are surrounded by crescents. The interstitial space is enlarged by marked fibrosis. A, hematoxylin-eosin; B, periodic acid-Schiff; C and D, trichrome. Scale bar 50 mum (A-C) and 200 mum (D).
case_images: 1414-431X-bjmbr-57-e13466-gf001.jpg
case_images: PMC11085031_01_1414-431X-bjmbr-57-e13466-gf001.jpg
case_images: f01
case_images: Furthermore, marked interstitial fibrosis (70-80%) and an interstitial mononuclear inflammatory infiltrate, as well as frequent red cell casts and foam cells filling the tubules were observed (Figure 1).
case_images: Immunofluorescence microscopy. A positive linear pattern of strong intensity for IgA in the capillary loops was observed along the glomerular basement membrane. Strong immunolabeling of the same pattern is associated with C3, kappa (K), and lambda (L). IgA, kappa, and lambda were also positive and linear in tubular membrane and Bowman's capsule. The other markers, including IgG, fibrinogen, and C1q were negative. Scale bar 50 mum.
case_images: 1414-431X-bjmbr-57-e13466-gf002.jpg
case_images: PMC11085031_01_1414-431X-bjmbr-57-e13466-gf002.jpg
case_images: f02
case_images: Kappa staining was positive and with a linear pattern in capillary loops along the glomerular basement membrane, in tubular membranes, and Bowman's capsule; lambda staining was also positive, with linear pattern in capillary loops along the glomerular basement membrane (Figure 2).