case_images: PMC8407559_01
case_images: Study flowchart.. * Negative or missing cultures at baseline were excluded.
case_images: pone.0256464.g001.jpg
case_images: PMC8407559_02_pone.0256464.g001.jpg
case_images: pone.0256464.g001
case_images: Following BMA, the most parsimonious model retained age, fosfomycin treatment, and recruitment site (TA) as independent predictors for clinical failure, and age for microbiologic failure (S2-S4 Figs in S1 Appendix). In patients >52 years old, nitrofurantoin remained superior to fosfomycin in terms of clinical, but not microbiologic, success (Table 2, S1 Fig in S1 Appendix).
case_images: Variation of clinical and microbiological failure across different age groups and treatment groups.
case_images: pone.0256464.g002.jpg
case_images: PMC8407559_01_pone.0256464.g002.jpg
case_images: pone.0256464.g002
case_images: Women who experienced clinical or microbiologic failure by day 28 were on average 10 years older (mean age 56.8 +-22.5 and 58.0 +-20.8 versus 45.8 +-19.6 and 47.2 +-20.7 years, respectively, [p<0.001]); the same pattern was seen in the E. coli subgroup (Fig 2, S1 Fig in S1 Appendix).
case_images: PMC8407559_02
case_images: Study flowchart.. * Negative or missing cultures at baseline were excluded.
case_images: pone.0256464.g001.jpg
case_images: PMC8407559_02_pone.0256464.g001.jpg
case_images: pone.0256464.g001
case_images: Following BMA, the most parsimonious model retained age, fosfomycin treatment, and recruitment site (TA) as independent predictors for clinical failure, and age for microbiologic failure (S2-S4 Figs in S1 Appendix). In patients >52 years old, nitrofurantoin remained superior to fosfomycin in terms of clinical, but not microbiologic, success (Table 2, S1 Fig in S1 Appendix).
case_images: Bacterial population isolated from urinary culture among different age groups.
case_images: pone.0256464.g003.jpg
case_images: PMC8407559_02_pone.0256464.g003.jpg
case_images: pone.0256464.g003
case_images: No significant variation was observed for these pathogens across different age categories (Fig 3).