case_images: PMC10808516_01
case_images: Clinical features. Case 1 (A, B) Buccal mucosa ulcers (A) and skin eruption on the trunk and limbs (B). Case 2 (C) Skin eruptions on the limbs. Case 3 (D) Skin eruptions on the trunk. Case 4 (E) Multiple areas of denuded skin on the limbs were noted.
case_images: fimmu-14-1291564-g001.jpg
case_images: PMC10808516_04_fimmu-14-1291564-g001.jpg
case_images: f1
case_images: Moreover, necrosis of buccal and urethral mucosa was significant with exudation ( Figure 1E ).
case_images: Histological features. Case 1 (A) Histological examination of the biopsy revealed interface dermatitis with whole-layer epidermal necrosis and dermal-epidermal separation and perivascular infiltration of lymphocytes in the upper dermis. Case 2 (B) Histopathological examination showed severe interface dermatitis with confluent apoptotic keratinocytes and perivascular lymphocyte and eosinophil infiltration was observed in the upper dermis. The scale bar indicates 100mm.
case_images: fimmu-14-1291564-g002.jpg
case_images: PMC10808516_02_fimmu-14-1291564-g002.jpg
case_images: f2
case_images: Histopathological findings were consistent with the diagnosis of drug eruptions including epidermal necrosis and perivascular infiltrated lymphocytes and eosinophils in the upper dermis ( Figure 2B ).
case_images: The timeline of medication history and treatments of Case1-4. (A) The timeline of case 1. (B) The timeline of case 2. (C) The timeline of case 3. (D) The timeline of case 4.
case_images: fimmu-14-1291564-g003.jpg
case_images: PMC10808516_04_fimmu-14-1291564-g003.jpg
case_images: f3
case_images: TEN was made and the patient's severity-of-illness score for TEN (SCORTEN) was 5, which indicated a quite poor prognosis. Though in-time and powerful medical care including large dose methylprednisolone (80mg/day) and 80mg adalimumab once was given, he passed away due to multi-organ failure within 3 days ( Figure 3D ).
case_images: PMC10808516_02
case_images: Clinical features. Case 1 (A, B) Buccal mucosa ulcers (A) and skin eruption on the trunk and limbs (B). Case 2 (C) Skin eruptions on the limbs. Case 3 (D) Skin eruptions on the trunk. Case 4 (E) Multiple areas of denuded skin on the limbs were noted.
case_images: fimmu-14-1291564-g001.jpg
case_images: PMC10808516_04_fimmu-14-1291564-g001.jpg
case_images: f1
case_images: Moreover, necrosis of buccal and urethral mucosa was significant with exudation ( Figure 1E ).
case_images: Histological features. Case 1 (A) Histological examination of the biopsy revealed interface dermatitis with whole-layer epidermal necrosis and dermal-epidermal separation and perivascular infiltration of lymphocytes in the upper dermis. Case 2 (B) Histopathological examination showed severe interface dermatitis with confluent apoptotic keratinocytes and perivascular lymphocyte and eosinophil infiltration was observed in the upper dermis. The scale bar indicates 100mm.
case_images: fimmu-14-1291564-g002.jpg
case_images: PMC10808516_02_fimmu-14-1291564-g002.jpg
case_images: f2
case_images: Histopathological findings were consistent with the diagnosis of drug eruptions including epidermal necrosis and perivascular infiltrated lymphocytes and eosinophils in the upper dermis ( Figure 2B ).
case_images: The timeline of medication history and treatments of Case1-4. (A) The timeline of case 1. (B) The timeline of case 2. (C) The timeline of case 3. (D) The timeline of case 4.
case_images: fimmu-14-1291564-g003.jpg
case_images: PMC10808516_04_fimmu-14-1291564-g003.jpg
case_images: f3
case_images: TEN was made and the patient's severity-of-illness score for TEN (SCORTEN) was 5, which indicated a quite poor prognosis. Though in-time and powerful medical care including large dose methylprednisolone (80mg/day) and 80mg adalimumab once was given, he passed away due to multi-organ failure within 3 days ( Figure 3D ).
case_images: PMC10808516_03
case_images: Clinical features. Case 1 (A, B) Buccal mucosa ulcers (A) and skin eruption on the trunk and limbs (B). Case 2 (C) Skin eruptions on the limbs. Case 3 (D) Skin eruptions on the trunk. Case 4 (E) Multiple areas of denuded skin on the limbs were noted.
case_images: fimmu-14-1291564-g001.jpg
case_images: PMC10808516_04_fimmu-14-1291564-g001.jpg
case_images: f1
case_images: Moreover, necrosis of buccal and urethral mucosa was significant with exudation ( Figure 1E ).
case_images: The timeline of medication history and treatments of Case1-4. (A) The timeline of case 1. (B) The timeline of case 2. (C) The timeline of case 3. (D) The timeline of case 4.
case_images: fimmu-14-1291564-g003.jpg
case_images: PMC10808516_04_fimmu-14-1291564-g003.jpg
case_images: f3
case_images: TEN was made and the patient's severity-of-illness score for TEN (SCORTEN) was 5, which indicated a quite poor prognosis. Though in-time and powerful medical care including large dose methylprednisolone (80mg/day) and 80mg adalimumab once was given, he passed away due to multi-organ failure within 3 days ( Figure 3D ).
case_images: PMC10808516_04
case_images: Clinical features. Case 1 (A, B) Buccal mucosa ulcers (A) and skin eruption on the trunk and limbs (B). Case 2 (C) Skin eruptions on the limbs. Case 3 (D) Skin eruptions on the trunk. Case 4 (E) Multiple areas of denuded skin on the limbs were noted.
case_images: fimmu-14-1291564-g001.jpg
case_images: PMC10808516_04_fimmu-14-1291564-g001.jpg
case_images: f1
case_images: Moreover, necrosis of buccal and urethral mucosa was significant with exudation ( Figure 1E ).
case_images: The timeline of medication history and treatments of Case1-4. (A) The timeline of case 1. (B) The timeline of case 2. (C) The timeline of case 3. (D) The timeline of case 4.
case_images: fimmu-14-1291564-g003.jpg
case_images: PMC10808516_04_fimmu-14-1291564-g003.jpg
case_images: f3
case_images: TEN was made and the patient's severity-of-illness score for TEN (SCORTEN) was 5, which indicated a quite poor prognosis. Though in-time and powerful medical care including large dose methylprednisolone (80mg/day) and 80mg adalimumab once was given, he passed away due to multi-organ failure within 3 days ( Figure 3D ).