case_images: PMC10688263_01
case_images: Contrast-enhanced chest CT angiography showing dilatation of the aortic root with a diameter greater than 50 mm in the ascending segment, the ascending segment 45 mm, the aortic arch 32 mm and the descending segment 22 mm.
case_images: autopsy-13-e2023449-g01.jpg
case_images: PMC10688263_01_autopsy-13-e2023449-g01.jpg
case_images: gf01
case_images: On angiotomography, the aortic root measured 50 mm (Figure 1), the ascending segment 45 mm, the aortic arch 32 mm, the descending segment 22 mm, and the abdominal segment 17 mm.
case_images: Photomicrographs of an aortic leaflet. In the panel A - with diffuse thickening and chronic inflammatory infiltrate; in the panel B - the arrows point to a Langerhans-type giant cell within the inflammatory infiltrate. Hematoxylin-eosin staining, objective magnifications 10x and 40x, respectively.
case_images: autopsy-13-e2023449-g02.jpg
case_images: PMC10688263_01_autopsy-13-e2023449-g02.jpg
case_images: gf02
case_images: The diagnosis was giant-cell valvulitis with fibrinoid necrosis (Figure 2).
case_images: Photomicrographs of the aortic wall showing in panel A - the diffuse involvement of the layers by chronic inflammatory infiltrate; in panel B - a close-up view shows a giant cell within the inflammatory infiltrate. Hematoxylin-eosin staining, objective magnifications 5x and 40x respectively.
case_images: autopsy-13-e2023449-g03.jpg
case_images: PMC10688263_01_autopsy-13-e2023449-g03.jpg
case_images: gf03
case_images: Photomicrographs of the aortic and valvar tissue submitted to immunohistochemical reactions for macrophages (CD68 antigen). In A - the positive cells are concentrated in the external half of the aortic wall, near the adventitia; Panel B - depicts positive macrophages in one aortic leaflet. Objective magnifications are respectively A - 5x; and B - 20x. Mouse monoclonal antibody CD68 (clone KP1), counter-staining with Harry's Hematoxylin.
case_images: autopsy-13-e2023449-g04.jpg
case_images: PMC10688263_01_autopsy-13-e2023449-g04.jpg
case_images: gf04