case_images: PMC11449193_01
case_images: Microscopic finding of the rectosigmoid polyp. a Pedunculated polyp composed of tubular structures (HE. x1). b Low-grade conventional dysplasia and CCC was visible in a patchy manner (HE. x10). c Clear cells were visible with vacuolated cytoplasm and eventually signet ring cell morphology (HE. x15). d Mutant phenotype was observed with p53 (p53. x10). HE, hematoxylin and eosin staining.
case_images: pat-2024-0091-0005-538705_F01.jpg
case_images: PMC11449193_01_pat-2024-0091-0005-538705_F01.jpg
case_images: F1
case_images: Histologically, predominantly clear cells (>80%) with vacuolated cytoplasm were visible, with sparse epithelial cells resembling "conventional" dysplasia (Fig. 1a, b). Eventually, signet ring cell morphology was present, as well (Fig. 1c). Immunohistochemical (IHC) examination was performed, p53 reflected mutant phenotype (Fig. 1d), while glypican 3, Sal-like protein 4 (SALL4), Alpha fetoprotein (AFP), and Cluster of differentiation 10 (CD10) were negative.