case_images: PMC11829699_01
case_images: Clinical features. A and B: Cervical and inguinal lymphadenopathy, with emphasis on the growth of the left node that was used for histological study. C: Splenomegaly, with a transverse measurement of 18 cm. D: Hepatomegaly measuring 17.48 cm. E and F: Lytic lesions in the thoracic vertebrae. G: Pleural effusion at hospital admission. H: Pleural effusion after drainage and decortication.
case_images: cureus-0017-00000077541-i01.jpg
case_images: PMC11829699_01_cureus-0017-00000077541-i01.jpg
case_images: FIG1
case_images: Acinetobacter lwoffii/haemolyticus (pansensitive) and Staphylococcus haemolyticus in two cultures. A computed tomography (CT) scan showed cervical and abdominopelvic adenopathies, osteolytic lesions, bilateral pleural effusion (predominantly left-sided), hepatosplenomegaly, and a hypodense splenic lesion (Figure 1).
case_images: Immunohistochemistry. Figure 2: A: S100 (400x). B: CD68 (400x). C: CD1A (400x). D: CD30 (400x). S100, CD68 and CD68 positive markers, CD30 negative. Interstitial Langerhans cells exhibit an immunohistochemical profile of CD1a+, S100+ according to the Histiocyte Society as strong evidence of diagnosis in almost 100% of cases. There is also the presence of some histiocytic markers such as CD68 with positivity in approximately 98% of cases, isolated expression of CD35 can occur. According to the literature, CD30 is only found in rare cases of true histiocytic tumors.
case_images: cureus-0017-00000077541-i02.jpg
case_images: PMC11829699_01_cureus-0017-00000077541-i02.jpg
case_images: FIG2
case_images: Inguinal lymph node biopsy with immunohistochemical analysis confirmed LCH, with positive S100, CD1a, and CD68 markers and negative CD30 (Figure 2).