case_images: PMC11367585_01
case_images: Diagnostic features of phospholipase A2 receptor (PLA2R)-negative membranous glomerulonephritis: glomerular basement membrane thickening (Jones silver stain), IgG+ granular peripheral capillary loop immune deposits (IgG immunofluorescence), negative PLA2R (PLA2R immunofluorescence), and subepithelial electron-dense deposits with capillary wall remodeling (electron microscopy (EM)). Additional features of IgG4-related renal disease: glomerular IgG+ deposits and tubulointerstitial IgG+ plasma cells (IgG4 immunoperoxidase stain). EM: 4800x magnification, 5 microm scale bar. Other images: 400x magnification, 50 microm scale bars.
case_images: 10.1177_2050313X241279696-fig1.jpg
case_images: PMC11367585_01_10.1177_2050313X241279696-fig1.jpg
case_images: fig1-2050313X241279696
case_images: Immunofluorescence and electron microscopy were diagnostic of phospholipase A2 receptor (PLA2R) negative membranous glomerulonephritis (MN) with moderate chronicity (Figure 1).