case_images: PMC10791960_01
case_images: Histomorphology of the tumor: (A) at low magnification, the tumor cells appeared to be epithelioid, arranged in patches and nests (x200). (B) The tumor cells were large in size, the cytoplasm brightly eosinophilic, nuclei prominent, oval with coarse chromatin, and distinct nucleoli; mitotic figures were frequently seen (as shown by the arrow) (x400). (C) Visible tumor necrosis (x100). (D) Intravascular tumor thrombi can be found in the adipose tissue surrounding the tumor (x100).
case_images: fonc-13-1321565-g001.jpg
case_images: PMC10791960_01_fonc-13-1321565-g001.jpg
case_images: f1
case_images: They were arranged in patches and nests pattern (Figure 1A). Pathological mitotic figures were easily found (10 mitoses per 10 high-power field) (Figure 1B). Partial areas showed patchy necrosis (Figure 1C), and multiple intravascular tumor thrombi can be seen in the lymph node capsule and surrounding adipose tissue (Figure 1D).
case_images: Immunophenotype and in situ hybridization features of the tumor: tumor cells immunohistochemistry staining results [(A), CD21; (B), CD23; and (C), CD30]; in situ hybridization result of EBER (D), all magnification x200.
case_images: fonc-13-1321565-g002.jpg
case_images: PMC10791960_01_fonc-13-1321565-g002.jpg
case_images: f2
case_images: Immunohistochemistry, the tumor cells were positive for CD21 (Figure 2A), CD23 (Figure 2B), CD30 (Figure 2C), CD68, and Vimentin. Chromogenic in situ hybridization showed strong and uniform nuclear positivity of EBER in the neoplastic cells (Figure 2D).