case_images: PMC10730678_01
case_images: The CT and MRI imaging examination of the patient. (A) The subcutaneous lesion on the right chest wall. (B) The lobar nodule in the left upper lung. (C) The enlarged lymph nodes in the mediastinum. (D, E) The brain metastases in cerebellum and left parietal lobe. (F) The metastatic lesion in right adrenal. All the lesions are indicated by the red arrows.
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case_images: Figures 1A-C ). Further magnetic resonance imaging (MRI) examinations revealed multiple brain metastases and metastasis to the right adrenal gland ( Figures 1D-F ). Human epidermal growth factor receptor 2 (HER2, IHC score 2+) ( Figure 2B ), membranous epidermal growth factor receptor (EGFR) ( Figure 2C ) and estrogen receptor (ER) (more than 40%,  Figure 2D ), progesterone receptor (PR) was negative ( Supplementary Figure 1A ), suggesting the possibility of male breast cancer. However, no lesions were found in the breast area of the patient. The immunohistochemical analysis indicated positive membranous staining for beta-catenin ( Figure 3B ) and EGFR (only in the tumor cell membrane,  Figure 3C ), negative staining for TTF-1 ( Figure 3D ), alpha-fetoprotein (AFP) and P53 ( Supplementary Figures 1B, C ).
case_images: The Pathological findings of subcutaneous nodule on the right chest wall mass. (A) Hematoxylin and eosin staining identified complex and disorganized glandulars structures at 100x magnification. (B-D) Immunohistochemical analysis indicated that tumor cells were immunoreactive for HER2 (++, B), EGFR (C) and ER (D) at the magnification of x100.
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case_images: Hematoxylin and eosin staining identified complex and disorganized glandular structures ( Figure 2A ). Human epidermal growth factor receptor 2 (HER2, IHC score 2+) ( Figure 2B ), membranous epidermal growth factor receptor (EGFR) ( Figure 2C ) and estrogen receptor (ER) (more than 40%,  Figure 2D ), progesterone receptor (PR) was negative ( Supplementary Figure 1A ), suggesting the possibility of male breast cancer. However, no lesions were found in the breast area of the patient.
case_images: The pathological findings of lobar nodule in the left upper lung. (A) Hematoxylin and eosin staining showed disorganized glandulars structures resembling fetal lungs at 100x magnification. (B-D) Immunohistochemical analysis indicated that tumor cells were immunoreactive for beta-catenin (B), EGFR (C) and TTF1 (D) at the magnification of x100.
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case_images: Hematoxylin and eosin staining showed complex and disorganized glandular structures resembling fetal lungs ( Figure 3A ). The immunohistochemical analysis indicated positive membranous staining for beta-catenin ( Figure 3B ) and EGFR (only in the tumor cell membrane,  Figure 3C ), negative staining for TTF-1 ( Figure 3D ), alpha-fetoprotein (AFP) and P53 ( Supplementary Figures 1B, C ).