case_images: PMC8009706_01
case_images: Halo nevus on the left upper arm. The central part shows only a light shadow while the rest of the lesion is depigmented.
case_images: CRIDM2021-6672528.001.jpg
case_images: PMC8009706_01_CRIDM2021-6672528.001.jpg
case_images: fig1
case_images: A 43-year-old man without medical history presented with an existing irregular halo and depigmented macule on the left upper arm for two and a half years that had changed according to the patient (Figure 1).
case_images: Intradermal atypical nevus cells in the left part of the biopsy, contrasting with regression in the right part (HE 5x).
case_images: CRIDM2021-6672528.002.jpg
case_images: PMC8009706_01_CRIDM2021-6672528.002.jpg
case_images: fig2
case_images: Histology of the halo nevus showed intradermal atypical nevus cells but also extensive regression in the superficial dermis (Figures 2 and 3).
case_images: Signs of extensive regression in the superficial dermis, lacking atypical melanocytes (HE 20x).
case_images: CRIDM2021-6672528.003.jpg
case_images: PMC8009706_01_CRIDM2021-6672528.003.jpg
case_images: fig3
case_images: Histology of the halo nevus showed intradermal atypical nevus cells but also extensive regression in the superficial dermis (Figures 2 and 3).
case_images: PMC8009706_02
case_images: Nevus on the right temporal area surrounded by a symmetrical rim of depigmentation.
case_images: CRIDM2021-6672528.004.jpg
case_images: PMC8009706_02_CRIDM2021-6672528.004.jpg
case_images: fig4
case_images: Clinical evaluation revealed a nevus with a halo of depigmentation measuring six by eight millimetres, with a central zone of homogenic pigmentation (Figure 4).
case_images: The lesion is characterized by atypical junctional activity and signs of extensive regression in the superficial dermis (HE x 10).
case_images: CRIDM2021-6672528.005.jpg
case_images: PMC8009706_02_CRIDM2021-6672528.005.jpg
case_images: fig5
case_images: Histology showed a melanocytic lesion with extensive regression at the margins of the lesion with only a few atypical cells in the dermis (Figure 5).
case_images: Immunohistochemistry shows bridging and pagetoid spread of atypical melanocytes (Melan A red x 10).
case_images: CRIDM2021-6672528.006.jpg
case_images: PMC8009706_02_CRIDM2021-6672528.006.jpg
case_images: fig6
case_images: In contrast, the centre of the lesion showed dense melanocytic proliferation with severe atypical features in the dermoepidermal junction as well as in the dermis (Figures 6).