case_images: PMC11001182_01
case_images: (a and b) Mild erythematous, scaly hyperpigmented lesions, and exfoliations over the bilateral palms and soles; (c) Cutaneous lesions were improved after 3 weeks when he was shifted to tenofovir-lamivudine-efavirenz from tenofovir-lamivudine-dolutegravir regimen
case_images: IJPharm-56-55-g001.jpg
case_images: PMC11001182_01_IJPharm-56-55-g001.jpg
case_images: ijp.ijp_258_23-F1
case_images: A 64-year-old male, who was on tenofovir-lamivudine-efavirenz (TLE) regimen for the last 5 years, had been referred from ART center for pruritic exfoliating skin lesions over the bilateral palms and soles when he was shifted to newly introduced tenofovir-lamivudine-dolutegravir (TLD) regimen 2 weeks back [Figure 1]. Cutaneous lesions regressed considerably after three weeks when he was shifted back to TLE from TLD regimen [Figure 1] and subjective improvement was noticed after 3 weeks.
case_images: Compact orthokeratosis, parakeratosis, irregular acanthosis, and superficial perivascular lymphocytic infiltrate along with mild basal cell vacuolar degeneration (low power, H and E, x10)
case_images: IJPharm-56-55-g002.jpg
case_images: PMC11001182_01_IJPharm-56-55-g002.jpg
case_images: ijp.ijp_258_23-F2
case_images: Histopathology of the affected skin showed hyperkeratosis, focal parakeratosis, and irregular acanthosis; few necrotic keratinocytes; and mild lymphocytic perivascular infiltration in the dermis [Figures 2 and 3].
case_images: (a) Scattered necrotic keratinocytes (black arrows); (b) Spongiosis and upper dermal infiltrate (high power, H and E, x40)
case_images: IJPharm-56-55-g003.jpg
case_images: PMC11001182_01_IJPharm-56-55-g003.jpg
case_images: ijp.ijp_258_23-F3
case_images: Histopathology of the affected skin showed hyperkeratosis, focal parakeratosis, and irregular acanthosis; few necrotic keratinocytes; and mild lymphocytic perivascular infiltration in the dermis [Figures 2 and 3].