case_images: PMC5312184_01
case_images: Lymphomatoid papulosis. A) Multiple erythematous papules, some with
  small erosions covered by scales and crusts and scarring lesions
  distributed symmetrically. B) Details of the lesions in three
  distinct evolutionary stages: the marking indicates a fully
  developed lesion (ideal for biopsy); under it, there is an ulcerated
  papule in involution; above, there is a completely regressed
  lesion
case_images: abd-92-01-0086-gf01.jpg
case_images: PMC5312184_01_abd-92-01-0086-gf01.jpg
case_images: f1
case_images: Affected areas included the trunk, buttocks, thighs, legs, arms, and forearms (Figure 1).
case_images: Lymphomatoid papulosis type C. A) Dermis showing a V-shaped cell
  infiltrate associated with blurring of the dermal-epidermal
  junction, rectification of epidermal cones, and hyperkeratosis
  (Hematoxylin & eosin x40). B) Dense cellular infiltrate on the
  dermis, consisting of lymphocytes with large pleomorphic vesicular
  nuclei and conspicuous cytoplasm. Some binucleate lymphocytes
  resembling Reed-Sternberg cells are present (Hematoxylin & eosin
  x400)
case_images: abd-92-01-0086-gf02.jpg
case_images: PMC5312184_01_abd-92-01-0086-gf02.jpg
case_images: f2
case_images: The biopsy of an infiltrated non-ulcerated papule revealed hyperkeratosis, rectification of the epidermis, and dense V-shaped infiltrate in the dermis, consisted of round cells with conspicuous cytoplasm and large pleomorphic vesicular nuclei, sometimes bevelled, displaying coarse nucleoli (Figure 2).
case_images: PMC5312184_02
case_images: Primary cutaneous anaplastic large cell lymphoma. Nodular and tumor
  lesions with ulcerated surface present on the right foot, leg, and
  arm
case_images: abd-92-01-0086-gf03.jpg
case_images: PMC5312184_02_abd-92-01-0086-gf03.jpg
case_images: f3
case_images: One month before, the patient presented with hardnodules on his right arm, leg and tight, following an upward path culminating in bulging in the ipsilateral inguinal region (Figure 3).
case_images: Primary cutaneous anaplastic large cell lymphoma. Dense diffuse
  infiltrate in the dermis, consisting of lymphocytes with large
  pleomorphic vesicular nuclei and conspicuous cytoplasm. Mitotic
  figures are easily visualized (Hematoxylin & eosin x400). Inset:
  diffuse positivity of neoplastic lymphocytes in immunohistochemical
  reaction with anti-CD30 primary antibody (Hematoxylin & eosin
  x400)
case_images: abd-92-01-0086-gf04.jpg
case_images: PMC5312184_02_abd-92-01-0086-gf04.jpg
case_images: f4
case_images: Mitoses were easily observed (Figure 4).
case_images: PMC5312184_03
case_images: Systemic anaplastic large T-cell lymphoma. Ulcerated nodule on the
  left scapular region
case_images: abd-92-01-0086-gf05.jpg
case_images: PMC5312184_03_abd-92-01-0086-gf05.jpg
case_images: f5
case_images: Dermatologic evaluation was requested due to a recent appearance of an ulcerated papule in the left scapular region (Figure 5).
case_images: Systemic anaplastic large T-cell lymphoma. Dense diffuse infiltrate
  in the dermis, consisting of lymphocytes with large pleomorphic
  vesicular nuclei and conspicuous cytoplasm (Hematoxylin & eosin
  x400). Inset: diffuse positivity of neoplastic lymphocytes in
  immunohistochemical reaction with anti-ALK primary antibody
  (Hematoxylin & eosin x400)
case_images: abd-92-01-0086-gf06.jpg
case_images: PMC5312184_03_abd-92-01-0086-gf06.jpg
case_images: f6
case_images: A biopsy revealed ulcerated skin fragment with diffuse infiltration, consisting of lymphoid cells containing large vesicular nuclei, with abundant pale cytoplasm (Figure 6).
case_images: PMC5312184_04
case_images: Large-cell transformation of mycosis fungoides. Plaque in polycyclic
  configuration with eroded surface. Ulceration covered by a blackened
  crust in the central portion. Note that the skin around the plaque
  reveals discreet erythema and fine scales that extended throughout
  the body
case_images: abd-92-01-0086-gf07.jpg
case_images: PMC5312184_04_abd-92-01-0086-gf07.jpg
case_images: f7
case_images: An 89-year-old female patient reported the appearance of nodular lesions on her left arm and in the posterior thoracic region, and a large eroded plaque with circinated edges in the right scapular region (Figure 7).
case_images: Large-cell transformation of mycosis fungoides. A) Dermis showing
  band-like infiltration in the papillary portion and around the skin
  appendages in depth (Hematoxylin & eosin x20). B) Dermis showing
  lymphocytes with large pleomorphic vesicular nuclei and abundant
  cytoplasm, interspersed with small lymphocytes and eosinophils
  (Hematoxylin & eosin x400)
case_images: abd-92-01-0086-gf08.jpg
case_images: PMC5312184_04_abd-92-01-0086-gf08.jpg
case_images: f8
case_images: Skin biopsy revealed an infiltrate with a striated distribution in the papillary dermis and perivascular at depth, consisted of lymphoid cells of broad cytoplasm and large pleomorphic vesicular nuclei with one or more nucleoli (Figure 8).