case_images: PMC9727144_01
case_images: Fetal echocardiography at 25+1 weeks of gestation. (A) The two-dimensional ultrasound image shows increased numbers of prominent trabeculations and deep intertrabecular spaces in both ventricles (yellow arrow), especially at the left ventricular apex. The ratio of non-compaction (6 mm) to compaction (2 mm) was 3:1. (B) The color Doppler ultrasound image shows blood perfusing the intertrabecular recesses (white arrow). LA, left atrium; LV, left ventricle; RA, right atrium; RV, right ventricle.
case_images: fped-10-1012600-g001.jpg
case_images: PMC9727144_01_fped-10-1012600-g001.jpg
case_images: F1
case_images: The ratio of non-compacted to compacted myocardium (N/C ratio) in the left and right ventricle was 3 and 2, respectively (Figure 1A). Color Doppler revealed blood perfusion to the intertrabecular recesses (Figure 1B).
case_images: Sanger sequencing electropherogram. The variant (c.389A > G) demonstrated the replacement of a conserved aspartic acid residue at position 130 with glycine (p.D130G) in the CALM2 gene (red arrow).
case_images: fped-10-1012600-g002.jpg
case_images: PMC9727144_01_fped-10-1012600-g002.jpg
case_images: F2
case_images: At autopsy, the biventricular wall contained increased numbers of prominent trabeculae and deep intertrabecular recesses (Figure 2).
case_images: Dissected autopsy specimen. The specimen showed excessive trabeculae and deep intertrabecular recesses within the biventricular myocardium.
case_images: fped-10-1012600-g003.jpg
case_images: PMC9727144_01_fped-10-1012600-g003.jpg
case_images: F3
case_images: Histopathologic examination confirmed fetal NCCM (Figure 3).
case_images: Histopathologic appearance of the myocardium at low magnification (hematoxylin and eosin, x40). The images were compatible with non-compaction cardiomyopathy, with cardiomyocyte disarray in the non-compacted layer (black arrow) in opposition to regular cardiomyocytes in the compacted layer (yellow arrow).
case_images: fped-10-1012600-g004.jpg
case_images: PMC9727144_01_fped-10-1012600-g004.jpg
case_images: F4
case_images: D130G) in CALM2 (Figure 4).