case_images: PMC11769844_01
case_images: Pedigree of proband from case 1. Circles represent females, squares - males. Affected individuals are colored figures. Proband marked by arrow.
case_images: CCID-18-223-g0001.jpg
case_images: PMC11769844_01_CCID-18-223-g0001.jpg
case_images: f0001
case_images: Clinical picture of hair loss pattern from case 1.
case_images: CCID-18-223-g0002.jpg
case_images: PMC11769844_02_CCID-18-223-g0002.jpg
case_images: f0002
case_images: Additionally, there is partial madarosis (Figures 2, 8 and 9) affecting both eyebrows and eyelashes, as well as sparse body hair.   
case_images: Madarosis clinical picture (cosmetic tattooing) from case 1.
case_images: CCID-18-223-g0003.jpg
case_images: PMC11769844_01_CCID-18-223-g0003.jpg
case_images: f0003
case_images: Additionally, there is complete madarosis (Figures 3 and 4) of both eyebrows and eyelashes, along with sparse body hair.
case_images: Dermoscopy of madarosis from case 1. Tattoo pigment, very sparse short, broken fine hair.
case_images: CCID-18-223-g0004.jpg
case_images: PMC11769844_01_CCID-18-223-g0004.jpg
case_images: f0004
case_images: Additionally, there is complete madarosis (Figures 3 and 4) of both eyebrows and eyelashes, along with sparse body hair.
case_images: Dermoscopy of hair from case 1.
case_images: CCID-18-223-g0005.jpg
case_images: PMC11769844_01_CCID-18-223-g0005.jpg
case_images: f0005
case_images: PMC11769844_02
case_images: Clinical picture of hair loss pattern from case 1.
case_images: CCID-18-223-g0002.jpg
case_images: PMC11769844_02_CCID-18-223-g0002.jpg
case_images: f0002
case_images: Additionally, there is partial madarosis (Figures 2, 8 and 9) affecting both eyebrows and eyelashes, as well as sparse body hair.   
case_images: Pedigree of proband from case 2. Circles represent females, squares - males. Affected individuals are colored figures. Proband marked by arrow.
case_images: CCID-18-223-g0006.jpg
case_images: PMC11769844_02_CCID-18-223-g0006.jpg
case_images: f0006
case_images: Clinical picture of hair loss pattern from case 2.
case_images: CCID-18-223-g0007.jpg
case_images: PMC11769844_02_CCID-18-223-g0007.jpg
case_images: f0007
case_images: Clinical examination: There is patterned alopecia affecting primarily the central portion of the scalp (Figure 7), with lateral extensions resembling a Christmas tree pattern, accompanied by slight parietal recession.
case_images: Madarosis clinical picture (cosmetic tattooing) from case 2.
case_images: CCID-18-223-g0008.jpg
case_images: PMC11769844_02_CCID-18-223-g0008.jpg
case_images: f0008
case_images: Additionally, there is partial madarosis (Figures 2, 8 and 9) affecting both eyebrows and eyelashes, as well as sparse body hair.   
case_images: Dermoscopy of madarosis from case 2. Tattoo pigment, sparse broken fine hair.
case_images: CCID-18-223-g0009.jpg
case_images: PMC11769844_02_CCID-18-223-g0009.jpg
case_images: f0009
case_images: Additionally, there is partial madarosis (Figures 2, 8 and 9) affecting both eyebrows and eyelashes, as well as sparse body hair.   
case_images: Dermoscopy of hair from case 2.
case_images: CCID-18-223-g0010.jpg
case_images: PMC11769844_02_CCID-18-223-g0010.jpg
case_images: f0010
case_images: Trichonodosis. Sample pictured here taken from case 2.
case_images: CCID-18-223-g0011.jpg
case_images: PMC11769844_02_CCID-18-223-g0011.jpg
case_images: f0011
case_images: Trichogram: 180 degree twisting point of hair shaft. Sample pictured here taken from case 2.
case_images: CCID-18-223-g0012.jpg
case_images: PMC11769844_02_CCID-18-223-g0012.jpg
case_images: f0012
case_images: Dermoscopy: Wiry coarse hair shaft with irregular twisting (Pili torti like changes). Sample pictured here taken from case 2.
case_images: CCID-18-223-g0013.jpg
case_images: PMC11769844_02_CCID-18-223-g0013.jpg
case_images: f0013
case_images: Light microscopy trichogram (Figure 13) of the hair performed in both cases revealed hairs that were coarse, flattened at irregular intervals with 180  twisting along their longitudinal axis.