case_images: PMC7399133_01
case_images: No abnormalities are detectable on the T1-weighted (A) and T2-weighted (B) magnetic resonance imaging (MRI) sequences. The diffusion-weighted imaging (DWI; C) shows the typical features of "cortical ribboning" in the cortex and subcortex of bilateral frontal, temporal, and occipital lobes on DWI (C). On the apparent diffusion coefficient map (ABC; D), there is low signal intensity in the cortex and subcortex of the bilateral frontal, temporal, and occipital lobes.
case_images: fneur-11-00763-g0001.jpg
case_images: PMC7399133_01_fneur-11-00763-g0001.jpg
case_images: F1
case_images: However, abnormal high signal in two or more cerebral cortex regions, referred to as "cortical ribboning" (Figure 1), and/or the basal ganglia, was incidentally found in the DWI of all four patients, which alerted physicians to suspect a diagnosis of CJD.
case_images: The typical presence of periodic sharp wave complexes (PSWCs) on the electrocephalogram of patient 1.
case_images: fneur-11-00763-g0002.jpg
case_images: PMC7399133_01_fneur-11-00763-g0002.jpg
case_images: F2
case_images: Patients 1 and 3 had characteristic period sharp wave complexes (PSWCs; Figure 2) recorded by EEG.