case_images: PMC3420753_01
case_images: FDG-PET: positive uptake of radiotracer in the right breast.
case_images: CRIM.HEMATOLOGY2011-914613.001.jpg
case_images: PMC3420753_01_CRIM.HEMATOLOGY2011-914613.001.jpg
case_images: fig1
case_images: Initial investigations included a computed tomography scans of the abdomen, thorax, and pelvis which failed to detect any further abnormality, a whole body positron emission tomography using 18F-fluorodeoxyglucose (FDG-PET) showed a positive uptake of radiotracer in the right breast suggesting a recurrent disease (Figure 1).
case_images: Neoplastic population basically formed by blasts.
case_images: CRIM.HEMATOLOGY2011-914613.002.jpg
case_images: PMC3420753_01_CRIM.HEMATOLOGY2011-914613.002.jpg
case_images: fig2
case_images: At light microscopy, a tumoral growth which diffusely infiltrated the mammary gland consisting mainly of blasts with variably shaped nuclei, multiple evident nucleoli, a rather dense chromatin and a moderate amount of cytoplasm was demonstrated (Figure 2).
case_images: CD34: intense positive immunostaining.
case_images: CRIM.HEMATOLOGY2011-914613.003.jpg
case_images: PMC3420753_01_CRIM.HEMATOLOGY2011-914613.003.jpg
case_images: fig3
case_images: Surprisingly, immunohistochemistry showed that the neoplastic cells were strongly stained for CD34 (Figure 3) and myeloperoxidase, being negative for the remaining cell markers employed CD79a, CD20, CD10, CD3, and Glycophorin A.