case_images: PMC10134144_01
case_images: A 4/5 subtotal gastrectomy specimen showing the 12 x 4.5 cm fleshy mass with a pale-tan surface arising in the wall of the fundus.
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case_images: Grossly, the specimen contained a 12 x 4.5 cm well-circumscribed fleshy mass with a pale-tan surface on sectioning arising in the subserosa of the stomach (Figure 1).
case_images: Hematoxylin-eosin, original magnification x200. Low-power view of gastric follicular dendritic cell sarcoma with a well-defined subserosal tumor.
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case_images: Microscopic examination revealed a multi-lobated mass centered in subserosa of the fundic wall (Figure 2).
case_images: The tumor is composed of plump spindle cells arranged in fascicular, storiform, and whorling patterns with lymphocytic infiltrate in the background (x200).
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case_images: Tumor cells had plump eosinophilic cytoplasm with ill-defined cell borders generating a patternless diffuse growth, despite some places having short fascicles of spindle-shaped cells that produced a vague storiform pattern (Figure 3).
case_images: Tumor cells had hyperchromatic to vesicular nuclei and occasional prominent nucleoli. A few multinucleated tumor cells were also observed (x400).
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case_images: Focal nuclear pleomorphism were seen (Figure 4).
case_images: FDCS with sprinkling of lymphocytes in the tumor background with a perivascular cuff of lymphocytes (x400).
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case_images: In background, sprinkling of small reactive lymphocytes was noted and in certain spots, a perivascular cuff of lymphocytes was also detected (Figure 5).
case_images: Immunohistochemical staining showing cytoplasmic and membranous positivity for CD21 (a) and CD23 (b). C-kit (c) and CD34 (d) are negative.
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case_images: AE1/AE3, S100, CD34, CD30, HMB45, and EBER (Figure 6). A diagnosis of an extra-nodal gastric FDCS with metastasis to regional lymph nodes was rendered.