case_images: PMC10619654_01
case_images: Location and next-generation sequencing (NGS) results of the three pulmonary lesions. (A) Chest computed tomography showed two ground-glass density nodules in S1 of the upper lobe of the right lung. (B) Genomic alterations detected via NGS analysis in three lesions.
case_images: fonc-13-1260759-g001.jpg
case_images: PMC10619654_01_fonc-13-1260759-g001.jpg
case_images: f1
case_images: The larger nodule (#1) was an irregular, partially solid nodule of 17 mm, and the other nodule (#2) was a pure ground-glass nodule of 16 mm ( Figure 1A ). MET, PTPRB, and SLIT2. EGFR showed a missense mutation (C.2573T>G, p.L858R) in exon 21. For nodule #2, there was a missense mutation in EGFR (c.2156G>C p.G719A) in exon 18. MUC21 mutation (c.1154G>A p.S385N) was present in lymph node #10 ( Figure 1B ).
case_images: Pathological and immunohistochemical examination results. (A) Lymph node #1 hematoxylin-eosin staining, magnification: x200. (B) Lymph node #2 hematoxylin-eosin staining, magnification: x200. (C) Lymph node #10 hematoxylin-eosin staining, magnification: x200. (D) Lymph node #1 SP125 positivity, magnification: x200. (E) Lymph node #1 SP125 negativity, magnification: x200. (F) Lymph node #10 SP125 positivity, magnification: x200.
case_images: fonc-13-1260759-g002.jpg
case_images: PMC10619654_01_fonc-13-1260759-g002.jpg
case_images: f2
case_images: We found that lymph nodes #1 and #10 were both positive for expression and considered lymph node #10 as a #1 lesion metastasis ( Figure 2 ).