case_images: PMC6082323_01
case_images: A few days after starting lymecycline for nodular acne of the trunk, a dramatic worsening of the clinical picture, with the occurrence of multiple, painful ulcerated nodules on the chest (A) and shoulders (B) associated with malaise and arthralgias, was observed.
case_images: ccid-11-403Fig1.jpg
case_images: PMC6082323_01_ccid-11-403Fig1.jpg
case_images: f1-ccid-11-403
case_images: After 4 days of treatment, a dramatic onset of multiple painful, ulcerated nodules on the trunk (Figure 1), associated with mild fever, headache, and diffuse arthralgias, occurred.
case_images: Regression of inflammatory nodules after 16-week isotretinoin treatment resulting in atrophic scars.
case_images: ccid-11-403Fig2.jpg
case_images: PMC6082323_01_ccid-11-403Fig2.jpg
case_images: f2-ccid-11-403
case_images: After 16 weeks, once the isotretinoin cumulative dose was 90 mg/kg and the inflammatory lesions had almost completely resolved in atrophic scars (Figure 2), retinoid therapy was withdrawn.
case_images: At follow-up visit 6 months after therapy cessation, no sign of relapse was observed. Some keloid scars developed on the chest (A) and shoulders (B).
case_images: ccid-11-403Fig3.jpg
case_images: PMC6082323_01_ccid-11-403Fig3.jpg
case_images: f3-ccid-11-403
case_images: At the 6-month follow-up visit, no signs of relapse were reported, while atrophic scars had turned into keloids (Figure 3).