case_images: PMC10824519_01
case_images: Computed tomography did not reveal any abnormalities, hepatomegaly, or splenomegaly. No abnormalities in the hepatobiliary system were observed (a: horizontal view, b: coronal view).
case_images: crg-2024-0018-0001-536097_F01.jpg
case_images: PMC10824519_01_crg-2024-0018-0001-536097_F01.jpg
case_images: F1
case_images: Computed tomography did not reveal any abnormalities in the biliary system or pancreas, and no gallstones were found (Fig. 1).
case_images: Histology of the biopsy specimen. a The central vein in the upper right of the image is surrounded by a rim of loose connective tissue with loss of hepatocytes (arrows). Scattered Coundilman's bodies (arrowheads) are observed in the lobule. b Interface activity by lymphocytic infiltrates in the portal area. A few eosinophils, as well as lymphocytes, are also observed in the necrotic foci in the lobule (arrows).
case_images: crg-2024-0018-0001-536097_F02.jpg
case_images: PMC10824519_01_crg-2024-0018-0001-536097_F02.jpg
case_images: F2
case_images: The inflammatory infiltrates in the portal area were primarily composed of lymphocytes, although few plasma cells were observed (Fig. 2).
case_images: Clinical course.
case_images: crg-2024-0018-0001-536097_F03.jpg
case_images: PMC10824519_01_crg-2024-0018-0001-536097_F03.jpg
case_images: F3
case_images: Finally, we made a definitive diagnosis of DILI due to the 5-ASA formulations based on the clinical course and liver biopsy results (Fig. 3).