case_images: PMC11808025_01
case_images: (A) IMT, digital pictures of hematoxylin and eosin (1) and immunohistochemistry with ALK showing strong cytoplasmic staining x20 magnification (2). (B) MRI in 01/2012 before the disarticulation surgery, axial and coronal T1. (C) Major partial response at treatment by ALECTINIB, coronal CT-scan 08/2021 (1) versus 11/2021 (2) and 11/05/2022 (3). (D) Chronologic evolution of treatments among our patient. In the upper part are the surgeries and different radiotherapies have been performed, in the lower part are the diagnosis and different chemotherapies/anti-ALK oral therapies.
case_images: fonc-14-1505257-g001.jpg
case_images: PMC11808025_01_fonc-14-1505257-g001.jpg
case_images: f1
case_images: A micro-biopsy was performed, which concluded to a fibromatous tumor ( Figure 1A ). The patient underwent an uncompleted R2 surgery in April 2007 due to proximity of vessels ( Figure 1B ). This treatment resulted in a significant partial radiologic response and clinical improvement, after three months of treatment, without significant toxicity ( Figure 1C ). Evolution of these different treatments is represented in  Figure 1D .