case_images: PMC11743898_01
case_images: Evolution of radiologic findings. Panels A and B: Panlobar multifocal ground glass opacities bilaterally and peribronchial condensations with a predominance in the lower lobes. Panels C and D: Resolution of apical ground glass opacities. Panels E and F: Near complete resolution of ground glass opacities with stabilization of peribronchial condensations.
case_images: gr1.jpg
case_images: PMC11743898_01_gr1.jpg
case_images: fig1
case_images: A chest CT scan showed panlobar multifocal bilateral ground glass opacities and peribronchial condensations with lower lobe predominance (Fig. 1A and B). A thoracic CT-scan performed one-month after AFOP diagnosis showed improvement of apical ground glass opacities (Fig. 1C and D). Thoracic CT scan 3 months after diagnosis showed a near-complete resolution of ground glass opacities with stabilization of peribronchial condensations (Fig. 1E and F).
case_images: Histopathological analysis of lung cryobiopsies. HE = Hematoxylin and Eosin coloration. Blue arrows show intra-alveolar fibrin deposition ("fibrin balls").
case_images: gr2.jpg
case_images: PMC11743898_01_gr2.jpg
case_images: fig2
case_images: Transbronchial lung cryobiopsies (TLCB) excluded acute cellular rejection (A0B0, negative C4d) but showed diffuse intra-alveolar fibroblastic plugs ("fibrin balls") confirming the diagnosis of AFOP (Fig. 2).