case_images: PMC10601620_01
case_images: Time course of relative strength during the observation period of 330 days. Each circle illustrates a strength measurement, and filled circles are measurements during the GH treatment period. The dotted 2nd degree polynomial regression line (REGpre-GH) is based on the first 10 pre-GH treatment measurement points. The continuous regression line during GH treatment (REGGH) revealed an increased slope. Gray circles are offset-corrected relative strength values after both training interruptions (in red rhombi).
case_images: crn-2023-0015-0001-530065_F01.jpg
case_images: PMC10601620_01_crn-2023-0015-0001-530065_F01.jpg
case_images: F1
case_images: A 2nd degree polynomial regression (named REGpre-GH) was calculated for all strength measurements prior to treatment to get an approximation of the natural course of strength gain (shown in Fig. 1 as a dotted line) and a second one for strength measurements during GH treatment (named REGGH, shown in Fig. 1 as a continuous line). Two intercepts were corrected to compensate for the setbacks in strength due to the abovementioned training interruptions: (a) training interruption due to medical problems right before the beginning of GH therapy and (b) COVID-19 (shown in Fig. 1). Therefore, all points past the onset of GH therapy were shifted by REGpre-GH at day 158 - Day158, and all points past the onset of COVID-19 were shifted by REGpre-GH at day 270 - Day270 (shown in Fig. 1 as gray circles).
case_images: Alterations of relative strength gains (RESIDUAL). First and second inpatient neurorehabilitation stays and GH treatment are indicated by boxes. The gray-orange line is a moving average of +-10 days, and pre-GH treatment values were set to zero for cross-correlational analyses.
case_images: crn-2023-0015-0001-530065_F02.jpg
case_images: PMC10601620_01_crn-2023-0015-0001-530065_F02.jpg
case_images: F2
case_images: For this purpose, both rehabilitation phases were excluded by setting RESIDUAL to 0 during the pretreatment period (shown in Fig. 2 as a gray line). alpha was set to 0.05.