case_images: PMC5726704_01
case_images: Previous treatments with hydrocortisone acetate cream 1% and hydroquinone
  cream 3% for one year, with no improvement. She denied respiratory or
  ocular symptoms. Physical examination revealed well-defined
  yellowish-brown infiltrated plaques located in the inner third of the
  eyebrows
case_images: abd-92-05-s1-0138-g01.jpg
case_images: PMC5726704_01_abd-92-05-s1-0138-g01.jpg
case_images: f1
case_images: She had a permanent makeup cosmetic tattoo 16 years before the onset of lesions (Figure 1).
case_images: A. Dense granulomatous infiltrate involving the entire
  dermis with presence of pigmented granules in the papillary dermis.
  Hematoxylin & eosin, X10. B. Epithelioid granulomas
  surrounded by lymphocytic infiltrates with black pigment in the central
  portion. Hematoxylin & eosin, X40
case_images: abd-92-05-s1-0138-g02.jpg
case_images: PMC5726704_01_abd-92-05-s1-0138-g02.jpg
case_images: f2
case_images: Histopathological examination of one of the lesions showed thick dermis with lymphocytic infiltrates around epithelioid granulomas involving the entire dermis, with presence of black pigment in the central portion (Figure 2).
case_images: PMC5726704_02
case_images: Physical examination showed areas of tattoos on his forearms, right thigh
  and foot with numerous salmon-colored papules and plaques with discrete
  scaling at the periphery
case_images: abd-92-05-s1-0138-g03.jpg
case_images: PMC5726704_02_abd-92-05-s1-0138-g03.jpg
case_images: f3
case_images: The second case was a 20-year-old man, tattoo artist, who reported the onset of painful lesions on 3 tattoos made one year and a half earlier (Figure 3).
case_images: A. Epithelioid granulomas with central black pigment
  involving the entire dermis with mild inflammatory infiltrate.
  Hematoxylin & eosin, X10. B. Epithelioid granuloma.
  Hematoxylin & eosin, X10
case_images: abd-92-05-s1-0138-g04.jpg
case_images: PMC5726704_02_abd-92-05-s1-0138-g04.jpg
case_images: f4
case_images: Histopathology revealed a sarcoidal granulomatous reaction (Figure 4).