case_images: PMC6079566_01
case_images: Breast MRI. Ill-defined deep retroareolar spiculate mass-like lesion extending over 3 x 1.5 cm revealing early enhancement peak with associated architectural distortion.
case_images: CRIS2018-8240534.002.jpg
case_images: PMC6079566_01_CRIS2018-8240534.002.jpg
case_images: fig2
case_images: Findings were suggestive of BIRADS type IV lesion (Figure 2).
case_images: (a and b) Low magnification histopathological examination of the breast tumor demonstrating nests of neoplastic epithelial cells in a background of dense lymphocytic infiltrate. (c and d) Higher magnification showing the tumor cells with abundant pale cytoplasm, large vesicular nuclei, and prominent nucleolus (hematoxylin and eosin stain).
case_images: CRIS2018-8240534.003.jpg
case_images: PMC6079566_01_CRIS2018-8240534.003.jpg
case_images: fig3
case_images: An excisional biopsy was performed and revealed breast tissue with extensive lymphocytic infiltrate intermixed with neoplastic epithelial cells (Figure 3).
case_images: The lymphocytes show positive immunohistochemical staining for CD3 (a), CD20 (b), and the tumor cell-positive immunohistochemical staining for cytokeratin AE1/AE3 (c).
case_images: CRIS2018-8240534.004.jpg
case_images: PMC6079566_01_CRIS2018-8240534.004.jpg
case_images: fig4
case_images: Immunohistochemistry results were positive for CK AE1/E3 antibody in the neoplastic epithelial cells with no expression of estrogen or progesterone receptors, and HER2/neu was not overexpressed (Figure 4(c)). The lymphocytes in the background stained positive for both CD3 and CD20 (Figures 4(a) and 4(b)).