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case_images: Dermatological symptoms in our familial reactive perforating collagenosis (RPC) patient. The patient presented with generalized multiple hyperpigmented papules, particularly in (A) the facial, neck, (B) abdominal, and (C) extensor parts of the feet and (D) hands. As a repetitive cycle of resolution and exacerbation had happened multiple times, resolved lesions could be identified by the occurrence of post-inflammatory hyperpigmented macules.
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case_images: Resolved lesions from previous exacerbation could be identified by post-inflammatory hyperpigmented skin (Figure 1A-D).
case_images: Histopathological results from FRPC patient. (A and B) H&E staining on the biopsy specimen identified fibrocollagenous tissue, crateriform appearance (yellow box), and enhanced inflammatory lymphocytes (green arrows). (C and D) Mason's trichrome staining showed an infiltrated area of the epidermal layer (yellow box) with collagen fibers from the underlying dermis (green arrows). (Scale bar (A and C): 100 microm; Scale bar (B and D): 50 microm).
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case_images: Histopathological analysis based on H&E staining of the biopsy specimen revealed fibrocollagenous tissue, the keratinized epidermal layer that is covered by stratified squamous epithelium, crateriform appearance on the epidermis, and increased inflammatory lymphocytes (Figure 2A and B). Further histopathological examination by Masson trichrome staining confirmed collagen infiltration through the epidermis (Figure 2C and D).