case_images: PMC11253909_01
case_images: A - MRI of the right side of the neck (axial view) lesional area pointed with black&white arrowheads. Lesion appears heterogeneously hyperintense on T2 and STIR sequences and isointense on T1Wi; B - Gross view of the surgical specimen showing a single mass without distinction between sublingual and submandibular gland (white arrow) (scale bar= 1,5 cm).
case_images: autopsy-14-e2024500-g02.jpg
case_images: PMC11253909_01_autopsy-14-e2024500-g02.jpg
case_images: gf02
case_images: No invasion of the bone or tongue muscles was found (Figure 2A).
case_images: Photomicrograph of AdCC with distinct histopathologic features - A - Cribriform pattern; B - Tubular pattern; C - Solid pattern; D - Perineural invasion (Black arrow); E - Perivascular invasion (Red arrow); F - Intramuscular invasion; G - Hyalinization of stroma; H - areas of high-grade transformation; I - Few Clear cells in areas of high-grade transformation. (H&E, 100x).
case_images: autopsy-14-e2024500-g03.jpg
case_images: PMC11253909_01_autopsy-14-e2024500-g03.jpg
case_images: gf03
case_images: The present case of AdCC revealed some unique histopathological findings, as follows: (Figure 3): (i) Complete replacement of glandular tissue (submandibular and sublingual glands) by the tumor tissue; (ii) All three histological patterns i.e, Cribriform, tubular and solid were evident. (Figures 3A, 3B, and 3C); (iii) There was evidence of perineural [Classified as Extratumoral, peripheral as proposed by Miller et al.], perivascular and intramuscular invasion, along with areas of hyalinization in the connective tissue stroma. (Figures 3D, 3E, and 3F); (iv) The tumor core showed few areas of high-grade transformation and focal areas with clear cells. (Figures 3G, 3H, and 3I).