case_images: PMC8101656_01
case_images: Abdominal CT - A - (axial view) showing a 4.7 x 3.0cm soft-tissue density mass anterior to the left kidney, adjacent to the tail of the pancreas and the previous colonic anastomosis at the splenic flexure; B - (axial view) showing the rapid expanding tumor, 12.7 x 8.6cm, adherent to the nearby structures; C - (coronal view) showing the rapid expanding tumor, 12.7 x 8.6cm, adherent to the nearby structures.
case_images: autopsy-11-e2020224-gf01.jpg
case_images: PMC8101656_01_autopsy-11-e2020224-gf01.jpg
case_images: gf01
case_images: Photomicrographs of the tumor. A - showing atypical spindled cells within a collagenous stroma (H&E, x100); B - immunohistochemistry shows diffuse reactivity for MDM2 within tumor cell nuclei (x200); C - Fluorescence in situ hybridization for MDM2 (12q15) showing amplification of MDM2 (red signals) in comparison with centromere (green signals).
case_images: autopsy-11-e2020224-gf02.jpg
case_images: PMC8101656_01_autopsy-11-e2020224-gf02.jpg
case_images: gf02
case_images: Surgical biopsies were performed, which demonstrated a moderately cellular tumor composed of atypical spindle cells within a collagenous stroma (Figure 2A), reactivity for MDM2 on immunohistochemistry (Figure 2B) and MDM2 amplification by fluorescence in situ hybridization (Figure 2C), consistent with dedifferentiated liposarcoma.