case_images: PMC4510909_01
case_images: a Partial karyotype showing comprehensive characterization of the balanced rearrangement involving chromosome 13 and 15 in the father of the proband using various FISH probes as indicated in the figure. The paternal karyotype was thus redefined as 46,XY,t(13;15)(p11.2;q13.2). b Schematic diagram showing deleted region (DT1) harbouring various genes that were absent in the proband. Abbreviations: BP-Break point, IC-Imprinting Center, DT1-deletion type-1, DT2-deletion type-2
case_images: 13039_2015_163_Fig1_HTML.jpg
case_images: PMC4510909_01_13039_2015_163_Fig1_HTML.jpg
case_images: Fig1
case_images: This substantiated that the sSMC was a "by-product" of a balanced paternal translocation involving one chromosome 13 and 15 and mimicking a Robertsonian translocation.Breakpoints were located in 13p11.2 and 15q13.2 region and the karyotype was redefined as 46,XY,t(13;15)(p11.2;q13.2) (Fig. 1a).