case_images: PMC11746038_01
case_images: (A) Soft yellowish patches were observed on the left scalp. A flaky black nodule was observed in the lesion. (B) Histopathology showed epidermal erosion and necrosis, and basal-like cell tumor masses were seen in the superficial middle layer of the dermis, some of which were connected to the epidermis (hematoxylin and eosin staining; magnification:x100). (C) The tumor cells are small, the nuclei are deeply stained, round or oval, the shape is uniform, and the cytoplasm is less. There was no bridge between the tumor cells, the cells around the tumor were arranged in a palisade, and some tumor masses had pigmentation (hematoxylin and eosin staining; magnification:x200).
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case_images: f1
case_images: The dermatological assessment revealed a soft, yellowish patch measuring approximately 3.2 cm x 2.7 cm on the left scalp, accompanied by a flaky black nodule measuring 2.0 cm x 2.5 cm within the lesion ( Figure 1A ). There were no connections between the tumor cells, while the surrounding cells were arranged in a palisade formation, and some tumor masses displayed pigmentation ( Figures 1B, C ).
case_images: PMC11746038_02
case_images: (A) Soft yellowish patches were observed on the left scalp, accompanied by two black nodules within the lesions, which exhibited clear boundaries and a raised surface. (B) The dermoscopy revealed a large bluish-gray oval nest set against a pink background, along with shallow ulcers and a few localized white scales. (C) Histopathological findings indicated that the epidermal mutation was flat, with tumor cells displaying clear boundaries located in the dermis, most of which were connected to the epidermis. The morphology of the tumor cells resembled that of basal cells, and the surrounding cells were arranged in a palisade pattern. Additionally, artificial contraction spaces were noted, along with evidence of bleeding and pigmentation within the tumor (hematoxylin and eosin staining; magnification:x100).
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case_images: f2
case_images: Two black nodules, measuring 1.1 cm x 1.2 cm and 0.5 cm x 0.5 cm, were observed within the lesions, characterized by clear boundaries and a raised skin surface ( Figure 2A ). Notably, there were no dendritic telangiectasia or pigmented webs present ( Figure 2B ). Additionally, artificial contraction spaces were noted, along with evidence of bleeding and pigmentation within the tumor ( Figure 2C ).
case_images: PMC11746038_03
case_images: (A) Soft yellowish patches were observed in the left parieto-temporal region of the scalp. (B) Histopathological analysis revealed excessive epidermal keratosis, prolonged epidermal processes, and hyperplasia of sebaceous glands, which were present without corresponding hair follicles or sweat glands in the deep dermis and subcutaneous fat (hematoxylin and eosin staining; magnification:x100). (C) Clearly defined tumor masses were identified in the dermis, with some connected to the epidermis. These tumor masses consist of basal-like cells, and the surrounding cells are arranged in a palisade formation. Additionally, some tumor masses contain single or nested sebaceous differentiated cells interspersed within and around them (hematoxylin and eosin staining; magnification:x200).
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case_images: f3
case_images: Dermatological assessment identified a soft, yellowish patch measuring approximately 3.1 cm x 5.8 cm located on the left parietal and temporal regions of the scalp ( Figure 3A ). Histopathological analysis demonstrated excessive epidermal keratosis, prolonged epidermal processes, and hyperplasia of sebaceous glands without corresponding hair follicles, as well as sweat glands present in the deep dermis and subcutaneous fat ( Figure 3B ). Additionally, some tumor masses exhibited a mixture of single or nested sebaceous differentiated cells both within and around them ( Figure 3C ).
case_images: PMC11746038_04
case_images: (A) A leathery patch is observed at the top of the left frontal region, characterized by a rough surface and medium quality. Additionally, several gray-black patches of varying sizes and smooth surfaces are present. (B, C) Histopathological findings revealed an epithelial tumor composed of basal-like cells located in the superficial layer of the dermis. This tumor exhibited pigmentation and interstitial fibrous tissue hyperplasia, with local tumors associated with epidermal hyperplasia. Furthermore, artificial contraction spaces were noted (hematoxylin and eosin staining; magnification: Bx40, Cx100).
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case_images: f4
case_images: In addition to this patch, several gray-black lesions of varying sizes and smooth surfaces were observed, displaying slight elevation, uneven coloration, medium quality, and poor mobility ( Figure 4A ). Local tumors were associated with epidermal hyperplasia, and artificial contraction spaces were evident ( Figures 4B, C ).