case_images: PMC4729164_01
case_images: The presented 6-year-old girl with Costello syndrome after 30 months of treatment with rhGH. The pictures show typical phenotypic features of the syndrome: loose skin with deep palmar creases (a); abnormal feet position as a result of excessive joint laxity (b)
case_images: 13052_2015_209_Fig1_HTML.jpg
case_images: PMC4729164_01_13052_2015_209_Fig1_HTML.jpg
case_images: Fig1
case_images: At the age of 2 years and 9 months Costello syndrome was suspected on the basis of phenotypic traits (large mouth, wide lips, short nasal bridge, loose skin deeply fissured on the palms and soles of the feet, joint laxity, and abnormal feet position, Fig. 1) and case history.
case_images: The course of growth (a) and weight gain (b) in the patient before and during rhGH treatment
case_images: 13052_2015_209_Fig2_HTML.jpg
case_images: PMC4729164_01_13052_2015_209_Fig2_HTML.jpg
case_images: Fig2
case_images: The curves of the patient's body weight and height gain before and during rhGH treatment are shown in Fig. 2a and b.