case_images: PMC11233783_01
case_images: Before treatment, the patient's vulva was atrophied, sclerotic and white in a large area.
case_images: fmed-11-1422389-g001.jpg
case_images: PMC11233783_01_fmed-11-1422389-g001.jpg
case_images: fig1
case_images: Clinical examination revealed atrophied, white, and hardened mucosa in the labia minora (Figure 1).
case_images: Histopathology of vulvar lesions in VLS patients marked hyperkeratosis, follicular horn plugs, thickening of the epidermal spinous layer, focal liquefaction degeneration of basal cells, and localized homogeneous degeneration of the superficial dermis. Lymphocytes, neutrophils and histiocytes were seen around the blood vessels in the dermis.
case_images: fmed-11-1422389-g002.jpg
case_images: PMC11233783_01_fmed-11-1422389-g002.jpg
case_images: fig2
case_images: Perform a biopsy on the rash present on her right labia majora showed marked hyperkeratosis, follicular horn plugs, thickening of the epidermal spinous layer, focal vacuolar degeneration of basal cells, and localized homogeneous degeneration of the superficial dermis (Figure 2).
case_images: After treatment, the patient's skin area is significantly reduced and the skin becomes thinner.
case_images: fmed-11-1422389-g003.jpg
case_images: PMC11233783_01_fmed-11-1422389-g003.jpg
case_images: fig3
case_images: Over 4 months of dupilumab therapy, significant therapeutic effects were observed, PP-NRS is 1 and DLQI is 3, including vulvar skin thinning and pruritus relief without adverse reactions (Figure 3).