case_images: PMC8202299_01
case_images: Case 1:Edema over the periorbital region and cheek with surrounding erythema.
case_images: 10.1177_2050313X211023655-fig1.jpg
case_images: PMC8202299_01_10.1177_2050313X211023655-fig1.jpg
case_images: fig1-2050313X211023655
case_images: Patient denied a history of acne vulgaris. Physical examination revealed periorbital and maxillary facial edema with associated erythema extending over the malar region (Figure 1).
case_images: Low power (10x) magnification shows perivascular and perifollicular lymphoplasmacytic inflammatory infiltrate (black arrows) and ectatic superficial dermal blood vessels (green arrow).
case_images: 10.1177_2050313X211023655-fig2.jpg
case_images: PMC8202299_01_10.1177_2050313X211023655-fig2.jpg
case_images: fig2-2050313X211023655
case_images: A 4-mm punch biopsy showed mild spongiosis with peri-adnexal mixed infiltrate and dermal edema (Figure 2).
case_images: PMC8202299_02
case_images: Case 2:Edema predominantly over the periorbital region.
case_images: 10.1177_2050313X211023655-fig3.jpg
case_images: PMC8202299_02_10.1177_2050313X211023655-fig3.jpg
case_images: fig3-2050313X211023655
case_images: A 50-year-old Caucasian male with a past medical history significant for latent autoimmune insulin-dependent diabetes mellitus, rosacea, and acne vulgaris presented with chronic periorbital edema (Figure 3).
case_images: High power (40x) magnification shows spongiosis which is exaggerated in the dermo-epidermal junction (red arrow).
case_images: 10.1177_2050313X211023655-fig4.jpg
case_images: PMC8202299_02_10.1177_2050313X211023655-fig4.jpg
case_images: fig4-2050313X211023655
case_images: A 3-mm punch biopsy showed dermis with perivascular and perifollicular lymphoplasmacytic inflammation, solar elastosis, and superficial dermal telangiectasias (Figure 4).