case_images: PMC5506462_01
case_images: Case  2.
case_images: CRIOR2017-7402570.002.jpg
case_images: PMC5506462_01_CRIOR2017-7402570.002.jpg
case_images: fig2
case_images: MRI showed a diffuse-TGCT growth-pattern involving all compartments of the entire knee joint, including a Bakers cyst (Figures 2(a) and 2(b)).
case_images: PMC5506462_02
case_images: Case  3. Metal artefact reducing sequelae sagittal T2 weighted turbo inversion recovery MR image of the right knee of a 67-year-old male patient, with a TKR in situ. Extensive tumour progression around TKR and bone invasion is shown.
case_images: CRIOR2017-7402570.003.jpg
case_images: PMC5506462_02_CRIOR2017-7402570.003.jpg
case_images: fig3
case_images: Aggressive tumour progression, including bone involvement, provoked TKR failure (Figures 3, 4(a), and 4(b)).
case_images: Case  3. X-rays (anterior-posterior and sagittal) of failing total knee replacement, attributed to aggressive TGCT progression including bone involvement, after radiotherapy treatment.
case_images: CRIOR2017-7402570.004.jpg
case_images: PMC5506462_02_CRIOR2017-7402570.004.jpg
case_images: fig4
case_images: Aggressive tumour progression, including bone involvement, provoked TKR failure (Figures 3, 4(a), and 4(b)).
case_images: Case  3. PET-CT scan showing extensive TGCT around the right knee joint and multiple lung, pleural, and costal metastases. When pulmonary symptoms developed, an investigational tyrosine-kinase-inhibitor (TKI) was started ((a) prior to treatment; (b) after treatment), which had an effect on his pulmonary-metastases but not on his irradiated painful lymphedemic leg.
case_images: CRIOR2017-7402570.005.jpg
case_images: PMC5506462_02_CRIOR2017-7402570.005.jpg
case_images: fig5
case_images: When he developed pulmonary symptoms, an investigational TKI was started, which had an effect on his lung metastases but not on his irradiated painful lymphedemic leg (Figures 5(a) and 5(b)).
case_images: PMC5506462_03
case_images: Case  4. Knee-arthrodesis after multiple Dt-GCT surgeries in a 26-year-old man, using a compression plate and screws.
case_images: CRIOR2017-7402570.006.jpg
case_images: PMC5506462_03_CRIOR2017-7402570.006.jpg
case_images: fig6
case_images: During the following 13 years, the patient underwent a total of seven surgeries in an effort to treat Dt-GCT, including a knee-arthrodesis using a compression plate and screws (Figure 6).
case_images: Case  4. Sagittal T1 weighted Spectral Presaturation with Inversion Recovery MR image after intravenous contrast, of a 28-year-old male patient revealing a large, extra-articular TGCT tumour mass. Patients history describes multiple surgical treatments, including removal of osteosynthesis material for a knee-arthrodesis.
case_images: CRIOR2017-7402570.007.jpg
case_images: PMC5506462_03_CRIOR2017-7402570.007.jpg
case_images: fig7
case_images: Subsequently, a two-staged anterior and posterior debulking synovectomy was performed (Figure 7 shows MRI prior to debulking).