case_images: PMC11771726_01
case_images: Pelvic magnetic resonance imaging (A) shows an approximately 2.5 cm round mass in the vagina on T2-weighted transverse image and (B) T2-weighted sagittal image. The mass was excised tranvaginally (C) and measured 3 x 3 cm in size grossly (D).
case_images: medi-104-e41287-g001.jpg
case_images: PMC11771726_01_medi-104-e41287-g001.jpg
case_images: F1
case_images: Pelvic magnetic resonance imaging (MRI) revealed a 2.5 cm round tumor with high signal intensity on T2-weighted image, distinct from the surrounding organs (Fig. 1A and B). Parasitic fibroid or benign soft tissue tumor was diagnosed preoperatively, and the mass was excised transvaginally under general anesthesia (Fig. 1C). Grossly, the tumor was round, encapsulated, and 3 x 3 x 2.5 cm in size (Fig. 1D).
case_images: Histological examination of aggressive angiomyxoma. (A) Low magnification image of the tumor demonstrates the characteristic hypocellular stroma with prominent myxoid changes (H&E stain, original magnification: 40x). (B) High magnification image shows the intricate vascular network within the myxoid stroma (H&E stain, original magnification: 200x). Tumor cells show immunohistochemical expression for smooth muscle actin (C), desmin (D), estrogen receptor (E), and progesterone receptor (F) (original magnification: 200x).
case_images: medi-104-e41287-g002.jpg
case_images: PMC11771726_01_medi-104-e41287-g002.jpg
case_images: F2
case_images: AAM, with immunohistochemistry (IHC) staining showing actin and desmin positivity and CD34, cytokeratin, and S100 negativity (Fig. 2). Additionally, ER and PR were strongly positive, with a score of 8 (5 + 3 [proportion score + intensity score]) according to the Allred scoring system.