case_images: PMC5783106_01
case_images: VWF multimer analysis.. Note: Multimer analysis showed presence of low multimers but essentially near-complete absence of large and intermediate multimers, consistent with acquired type 2A VWD.. Abbreviations: VWF, von Willebrand factor; VWD, von Willebrand disease.
case_images: jbm-9-009Fig1.jpg
case_images: PMC5783106_01_jbm-9-009Fig1.jpg
case_images: f1-jbm-9-009
case_images: Multimer analysis showed presence of low multimers but essentially near-complete absence of large and intermediate multimers, consistent with acquired type 2A VWD (Figure 1).
case_images: Clinical pharmacokinetics of VWF and FVIII before and after surgery.. Notes: VWF activity (VWF:Ab) and FVIII levels improved with IVIG infusion but were <80% preoperatively. With a bolus infusion of Humate-P , both VWF:Ab and FVIII levels improved to >100% and remained stable for ~3 days after the thyroidectomy. The patient did not have any intra- or postoperative bleeding and recovered well from surgery.. Abbreviations: VWF, von Willebrand factor; FVIII, factor VIII; IVIG, intravenous immunoglobulin.
case_images: jbm-9-009Fig2.jpg
case_images: PMC5783106_01_jbm-9-009Fig2.jpg
case_images: f2-jbm-9-009
case_images: Daily plasma VWF:Ab and FVIII levels were checked for 3 days postoperatively, with levels remaining >100% (Figure 2).