case_images: PMC10601857_01
case_images: a A family tree of case 1 is shown. There is no family history of polydipsia and polyuria. b The family tree of cases 2 and 3 is shown. His father and sister admit to frequent urination during the day. No one else has frequent urination.
case_images: cnd-2023-0013-0001-533895_F01.jpg
case_images: PMC10601857_05_cnd-2023-0013-0001-533895_F01.jpg
case_images: F1
case_images: He was the younger brother of the patient described in "Case 2." Figure 1b shows the family tree.
case_images: PMC10601857_02
case_images: Water intake and urine volume at the first hospitalization of case 1 are shown. Water intake ranged from 930 mL to 1,110 mL, and urine output ranged from 553 mL to 792 mL. There was no significant change in water intake and urine volume after administration of desmopressin.
case_images: cnd-2023-0013-0001-533895_F02.jpg
case_images: PMC10601857_02_cnd-2023-0013-0001-533895_F02.jpg
case_images: F2
case_images: Because of the presence of polyuria and the high serum level of antidiuretic hormone (Tables 1, 2), CNDI was diagnosed; low-sodium milk, hydrochlorothiazide, and spironolactone were administered orally, and the infant's urine output did not change (Fig. 2).
case_images: The progress of height and weight and the course of treatment of case 1 are shown. He admits that he has a growth disorder. He was tube-fed until age 3 years and was on low-sodium milk until age 3 years due to poor oral intake. He is on hydrochlorothiazide and spironolactone. Both started at 2 mg/kg and are currently taking hydrochlorothiazide 5 mg/kg and spironolactone 4 mg/kg.
case_images: cnd-2023-0013-0001-533895_F03.jpg
case_images: PMC10601857_02_cnd-2023-0013-0001-533895_F03.jpg
case_images: F3
case_images: Figure 3 shows the clinical course.
case_images: PMC10601857_03
case_images: a A family tree of case 1 is shown. There is no family history of polydipsia and polyuria. b The family tree of cases 2 and 3 is shown. His father and sister admit to frequent urination during the day. No one else has frequent urination.
case_images: cnd-2023-0013-0001-533895_F01.jpg
case_images: PMC10601857_05_cnd-2023-0013-0001-533895_F01.jpg
case_images: F1
case_images: He was the younger brother of the patient described in "Case 2." Figure 1b shows the family tree.
case_images: Water intake and urine volume at first hospitalization for case 2 are shown. Water intake ranged from 680 mL to 9,350 mL, and urine output ranged from 461 mL to 960 mL. Hydrochlorothiazide and spironolactone were administered from day 3 of hospitalization. Both water intake and urine volume tended to decrease.
case_images: cnd-2023-0013-0001-533895_F04.jpg
case_images: PMC10601857_03_cnd-2023-0013-0001-533895_F04.jpg
case_images: F4
case_images: Hydrochlorothiazide and spironolactone were administered orally, and his urine output decreased to 650-700 mL/day (Fig. 4).
case_images: The progress of height and weight and the course of treatment for case 2 are shown. He had growth retardation until age 1, but improved after age 2, and is now within normal limits for height and weight. He is on hydrochlorothiazide and spironolactone. Both started at 2 mg/kg and are currently taking 4 mg/kg. He used low-sodium milk during his infancy. Salt restriction was 1 mEq/kg/day before starting baby food and 3 g/day after starting baby food.
case_images: cnd-2023-0013-0001-533895_F05.jpg
case_images: PMC10601857_03_cnd-2023-0013-0001-533895_F05.jpg
case_images: F5
case_images: Figure 5 shows the clinical course.
case_images: PMC10601857_04
case_images: PMC10601857_05
case_images: a A family tree of case 1 is shown. There is no family history of polydipsia and polyuria. b The family tree of cases 2 and 3 is shown. His father and sister admit to frequent urination during the day. No one else has frequent urination.
case_images: cnd-2023-0013-0001-533895_F01.jpg
case_images: PMC10601857_05_cnd-2023-0013-0001-533895_F01.jpg
case_images: F1
case_images: He was the younger brother of the patient described in "Case 2." Figure 1b shows the family tree.
case_images: Water intake and urine volume at initial hospitalization for case 3 are shown. Water intake ranged from 669 mL to 1,198 mL, and urine output ranged from 485 mL to 1,025 mL. From day 11 of hospitalization, hydrochlorothiazide, and spironolactone were administered. Both water intake and urine volume tended to decrease.
case_images: cnd-2023-0013-0001-533895_F06.jpg
case_images: PMC10601857_05_cnd-2023-0013-0001-533895_F06.jpg
case_images: F6
case_images: His urine output decreased to 650-750 mL/day (Fig. 6).
case_images: The height and weight of case 3 and the course of treatment are shown. His height and weight are passing within normal limits. He is on hydrochlorothiazide and spironolactone. Both were started at 2 mg/kg, and he is currently taking hydrochlorothiazide 3.5 mg/kg and spironolactone 3 mg/kg. He also used low-sodium milk during his infancy. Salt restriction was 1 mEq/kg/day before starting baby food and 3 g/day after starting baby food.
case_images: cnd-2023-0013-0001-533895_F07.jpg
case_images: PMC10601857_05_cnd-2023-0013-0001-533895_F07.jpg
case_images: F7
case_images: Figure 7 shows the clinical course.
case_images: PMC10601857_06