case_images: PMC6431470_01
case_images: (a) Hyperaemia and diffuse superficial ulcerations of left colon. (b), (c), and (d) The giant pseudopolyp in the cecum with a normal colonic mucosa.
case_images: CRIGM2019-5347637.001.jpg
case_images: PMC6431470_01_CRIGM2019-5347637.001.jpg
case_images: fig1
case_images: On January 2018, after 13 years of initial diagnosis and while she was clinically asymptomatic, a screening colonoscopy for colorectal cancer showed diffuse superficial ulcerations surrounded by an erythematous inflamed mucosa from the rectum to the splenic flexure (Figure 1(a)), a solitary sessile well circumscribed polyp in the cecum with normal adjacent mucosa, not amenable to endoscopic resection (Figures 1(b), 1(c), and 1(d)).
case_images: (a) Polypoid structure formed by disorganized and rarefied glands and crypts in an inflammatory and edematous lamina propria. (b)-(c) Inflammatory lamina propria and rarefied glands. (d) Cryptitis: exocytosis of polynuclear neutrophils in the glands.
case_images: CRIGM2019-5347637.002.jpg
case_images: PMC6431470_01_CRIGM2019-5347637.002.jpg
case_images: fig2
case_images: Complete resolution of cecal GIP after 8 months of adalimumab therapy.
case_images: CRIGM2019-5347637.003.jpg
case_images: PMC6431470_01_CRIGM2019-5347637.003.jpg
case_images: fig3
case_images: Eight months later, a surveillance colonoscopy showed complete regression of the giant pseudopolyp (Figures 3 and 4) with partial endoscopic remission of the previously noted inflammation of rectum and sigmoid.
case_images: Desquamation and damage to the surface epithelium. Architectural distortion: duplication of crypts and irregular glands of varying sizes. Inflammatory infiltrate formed by neutrophils and plasmocytes in the lamina propria.
case_images: CRIGM2019-5347637.004.jpg
case_images: PMC6431470_01_CRIGM2019-5347637.004.jpg
case_images: fig4
case_images: Eight months later, a surveillance colonoscopy showed complete regression of the giant pseudopolyp (Figures 3 and 4) with partial endoscopic remission of the previously noted inflammation of rectum and sigmoid.