case_images: PMC11439660_01
case_images: (A) Typical level and imaging findings of abdominal CT images for the lesion in the S4 segment of the liver; (B) abdominal MR typical images for the lesion in the S4 segment of the liver.
case_images: fmed-11-1437650-g001.jpg
case_images: PMC11439660_01_fmed-11-1437650-g001.jpg
case_images: fig1
case_images: Abdominal contrast-enhanced CT scan in June 2014 (Figure 1A) showed a large heterogeneous hypodense lesion with unclear boundaries in the S4 segment of the liver measured 7.1 x 6.1 cm.
case_images: (A-F) Histologic images of tumor tissues by hematoxylin and immunohistological staining in the S4 segment of the liver; (G-L) Histologic images of tumor tissues by hematoxylin and immunohistological staining in the S7 segment of the liver.
case_images: fmed-11-1437650-g002.jpg
case_images: PMC11439660_01_fmed-11-1437650-g002.jpg
case_images: fig2
case_images: Immunohistological results were positive including chromgranin A (CgA), cluster of differentiation 56 (CD56), cytokeratin (CK)8/18, epithelial membrane antigen (EMA), and Villin (Figures 2A-F). The immunohistochemical staining in the lesion cells was positive for CgA, Synaptophysin (Syn), CD 34, CK 8/18/19, EMA, and Villin (Figures 2G-L).
case_images: (A) CT image after resection the S4 segment of PHNET, (B-D) first post-operative negative images of chest CT, gastrointestinal endoscopy, and colonoscopy.
case_images: fmed-11-1437650-g003.jpg
case_images: PMC11439660_01_fmed-11-1437650-g003.jpg
case_images: fig3
case_images: Postoperative abdominal CT images showed that the density of hepatic parenchyma was homogeneous and no residual lesions were found (Figure 3A). The patient had an uneventful recovery after the procedure and underwent further investigation to rule out an extrahepatic origin of the NETs: gastrointestinal endoscopy, colonoscopy, and chest CT scan were negative (Figures 3B-D).
case_images: (A) Typical level and imaging findings of abdominal CT images for the recurrent lesion in the S7 segment of the liver; (B) abdominal MR typical images for the recurrent lesion in the S7 and S8 segment of the liver.
case_images: fmed-11-1437650-g004.jpg
case_images: PMC11439660_01_fmed-11-1437650-g004.jpg
case_images: fig4
case_images: CA-125, CA199, AFP, and CEA remained negative. CT scanning in June 2021(Figure 4A) exhibited new small patches of high-density lesions in the S7 segment of the liver. MR images in June 2021 (Figure 4B) slightly lower T1 and higher T2 signal foci were observed in the S7 and S8 segments of the liver presenting with a high signal intensity on DWI, and the enhancement pattern was consistent with CT.
case_images: Graphical illustration of a timeline fashion the course of the PHNET in case.
case_images: fmed-11-1437650-g005.jpg
case_images: PMC11439660_01_fmed-11-1437650-g005.jpg
case_images: fig5
case_images: Figure 5 shows the timeline for the occurrence and development course of the PHNET in our case.