case_images: PMC4731964_01
case_images: Gait neurophysiology. Legend: Cross-Covariance and Correlation of Ankle Angular Velocity in a healthy control (a), an idiopathic PD patient with a FoG episode, red shaded area (b), a representative vascular PD subject with a FoG episode (c), and in this patient (d). In order to overlap the right and left angular velocity signals, we calculated the lag between the right and left mid-swing peak by a cross-covariance between the two signals. Once the lag was determined, we shifted the signals by that amount so that the right and left shank angular velocities are synchronized. Then, we calculated the correlation between the two signals for each 0.5 s (fc = 200 samples/s). This approach allowed us to visually observe the strong asymmetry between the right and left leg during straight walking in this specific patient. The red shaded area in 1b, c, and d highlight FoG episodes during turning
case_images: 40734_2016_30_Fig1_HTML.jpg
case_images: PMC4731964_01_40734_2016_30_Fig1_HTML.jpg
case_images: Fig1
case_images: This phenomenon was only related to this case, and not seen in healthy control subjects, idiopathic PD or vascular parkinsonism (Fig. 1d vs. a, b, and c). The areas shaded in light blue (Fig. 1a vs. d) highlight this interesting non-reciprocal, floor scanning gait pattern.
case_images: Diffusion tensor imaging: interhemispheric fiber tracts connecting principal, homologous sensorimotor cortical regions. Legend: a The Human Motor Area Template as defined by Mayka et al., 2006. b Interhemispheric fiber tracts from a healthy young adult, color-coded to match the cortical regions shown in panel A, taken from Fling et al., 2013. c Patient's T1-weighted structural MRI showing an infarct within the anterior body of the corpus callosum. d Patient's fractional anisotropy map, derived from diffusion weighted data. Fiber tracts were readily identified connecting the S1, M1, and SMA. No fiber tracts connecting either the PMd or the pre-SMA were identified; the blue and orange outlines demonstrate the location in the callosum where these fiber tracts would be expected to cross. e & f White matter hyperintensities within bilateral anterior periventricular regions. S1 = primary somatosensory cortex; M1 = primary motor cortex; SMA = supplementary motor area; PMd = dorsal premotor cortex; PMv = ventral premotor cortex
case_images: 40734_2016_30_Fig2_HTML.jpg
case_images: PMC4731964_01_40734_2016_30_Fig2_HTML.jpg
case_images: Fig2
case_images: MRI of the brain showed a lesion in the anterior corpus callosum (Fig. 2c). Additional subcortical white matter changes were present in anterior periventricular and centrum semiovale regions, and were slightly more marked on the left (Fig. 2e and f). Probabilistic tractography derived from diffusion tensor imaging revealed interhemispheric fiber loss in regions of the corpus callosum responsible for connecting the dorsal premotor (PMd) and pre-supplementary motor areas (pre-SMA) (Fig. 2d). For representative control data, see Fig. 2a and b.