case_images: PMC11796133_01
case_images: (A) Sagittal CT scan of the chest demonstrating a compression fracture in the T7 vertebra (large white arrow), along with osteoporotic changes in the epiphyseal plates of multiple vertebrae (smaller white arrows). (B) Sagittal MRI scan of the lumbar spine revealing a compression fracture in L3 (white arrow).
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case_images: PMC11796133_01_oncoscience-12-614-g001.jpg
case_images: F1
case_images: A computed tomography (CT) scan of the chest demonstrated a wedge-shaped T7 fracture, along with osteoporotic changes in the epiphyseal plates of several vertebrae (Figure 1A). Additionally, an MRI scan with intravenous contrast revealed similar findings throughout the lumbar spine, along with an L3 vertebral fracture (Figure 1B).
case_images: (A) Hematoxylin - eosin stain, 20x magnification: Histopathological examination demonstrating mast cell aggregates infiltrating the bone marrow (white arrow). (B) Immunohistochemically, the cells stain positive for tryptase (10x magnification).
case_images: oncoscience-12-614-g002.jpg
case_images: PMC11796133_01_oncoscience-12-614-g002.jpg
case_images: F2
case_images: Histopathology revealed 15-20% bone marrow infiltration by multifocal aggregates of abnormal, spindle-shaped mast cells (Figure 2A). The mast cells stained positive for tryptase (Figure 2B), CD117 (Figure 3) and CD30, and negative for CD123, CD2 and CD25.
case_images: Immunohistochemical staining showing CD117 (KIT) positivity in mast cells (20x magnification).
case_images: oncoscience-12-614-g003.jpg
case_images: PMC11796133_01_oncoscience-12-614-g003.jpg
case_images: F3
case_images: The mast cells stained positive for tryptase (Figure 2B), CD117 (Figure 3) and CD30, and negative for CD123, CD2 and CD25.