case_images: PMC10699439_01
case_images: Clinical and imaging features of the 2 cases. (A) Abdominal CT image of Patient 1. (B) Small intestine endoscopy image of Patient 1. (C) Flowchart of Patient 1's diagnosis and treatment course. (D) Abdominal CT image of Patient 2. (E) Small bowel endoscopy image of Patient 2. (F) Flowchart of Patient 2's diagnosis and treatment course.
case_images: fonc-13-1265749-g001.jpg
case_images: PMC10699439_02_fonc-13-1265749-g001.jpg
case_images: f1
case_images: On January 4, 2023, the patient returned for a abdominal CT due to hoarseness and abdominal distension, which showed multiple enlarged lymph nodes in the 2R region of the mediastinum, thickening of the wall of the jejunum in the upper left abdomen ( Figure 1D ). On January 13, 2023, a small intestine endoscopy revealed a luminal growth in the upper part of the jejunum, located approximately 35 cm from the pylorus ( Figure 1E ), and biopsy confirmed poorly differentiated cancer. The patient is currently receiving regular treatment ( Figure 1F ).
case_images: PMC10699439_02
case_images: Clinical and imaging features of the 2 cases. (A) Abdominal CT image of Patient 1. (B) Small intestine endoscopy image of Patient 1. (C) Flowchart of Patient 1's diagnosis and treatment course. (D) Abdominal CT image of Patient 2. (E) Small bowel endoscopy image of Patient 2. (F) Flowchart of Patient 2's diagnosis and treatment course.
case_images: fonc-13-1265749-g001.jpg
case_images: PMC10699439_02_fonc-13-1265749-g001.jpg
case_images: f1
case_images: On January 4, 2023, the patient returned for a abdominal CT due to hoarseness and abdominal distension, which showed multiple enlarged lymph nodes in the 2R region of the mediastinum, thickening of the wall of the jejunum in the upper left abdomen ( Figure 1D ). On January 13, 2023, a small intestine endoscopy revealed a luminal growth in the upper part of the jejunum, located approximately 35 cm from the pylorus ( Figure 1E ), and biopsy confirmed poorly differentiated cancer. The patient is currently receiving regular treatment ( Figure 1F ).
case_images: Molecular features of the 2 patients. (A) Mutation genes and their mutation frequencies. (B) Comparison of mutation sites and their mutation frequencies.
case_images: fonc-13-1265749-g002.jpg
case_images: PMC10699439_02_fonc-13-1265749-g002.jpg
case_images: f2
case_images: We compiled the NGS results of both patients, including the lung tumor of patient 1 and the lung and small intestine masses of patient 2 ( Figure 2A ). FAT3, and PTPRS. Furthermore, we observed that both cases exhibited some shared genetic mutations, such as TP53 and LRP1B, while Patient 2 experienced a novel gene mutation, FGFR2, after small intestine metastasis ( Figure 2B ).