case_images: PMC10601821_01
case_images: a-j A 25-month-old boy with bilateral sporadic RB. The right eye was enucleated because of an advanced RB tumor. c He developed a large fast-growing subretinal pigmented mass 51 months after complete remission of primary lesions. d The dome-shaped bi-hump lesion had medium internal reflectivity without any calcification. e, f After brach1ytherapy, the lesion rapidly regressed. g, h The magnetic resonance imaging showed a dome-shaped lesion at the nasal side of the disc before treatment. i, j The lesion disappeared completely, and no recurrence and radiation retinopathy were formed during the 6 years of F/U.
case_images: cop-2023-0014-0001-531527_F01.jpg
case_images: PMC10601821_01_cop-2023-0014-0001-531527_F01.jpg
case_images: F1
case_images: The seeds disappeared spontaneously (Fig. 1a, b). Four months later, a pigmented subretinal mass (6 x 5 x 3 mm) was detected near the recent recurrence with different internal reflectivities in B-scan (Fig. 1c, d). The brain was normal (Fig. 1g, h). Rapid regression of choroidal mass was realistic proof for being RB (Fig. 1e, f). The patient's visual acuity was 20/20 on the last visit without any sign of radiation retinopathy, and the systemic workup was negative for any metastasis (Fig. 1i, j).
case_images: PMC10601821_02
case_images: A 4-month-old with chromosome 13 deletion and bilateral sporadic RB. a, c, e The right eye was enucleated because of a recalcitrant tumor and hyphema and anterior segment involvement. b, d, f The left eye was followed every month, and she had multiple recurrences and all treated by systemic or intra-arterial chemotherapy and local adjuvant treatments.
case_images: cop-2023-0014-0001-531527_F02.jpg
case_images: PMC10601821_02_cop-2023-0014-0001-531527_F02.jpg
case_images: F2
case_images: New recurrences appeared in OD; therefore, intra-arterial chemotherapy (IAC) was performed twice, but due to recurrence, dense vitreous hemorrhage, anterior segment involvement, and cataract formation, the eye was enucleated in January 2018 (Fig. 2a, b). In January 2020, a single lesion with localized vitreous seeds appeared at the nasal quadrant, and brachytherapy with 106 Ruthenium plaque (60 Gy) was performed (Fig. 2c, f).
case_images: The second case developed a cataract after 1 year from the last occurrence of the recurrences and anterior segment involvement. She was followed by B-scan and ultrasound biomicroscopy, and 12 months after the previous recurrence, a ring-shaped prominent mass appeared in the ciliary body area, causing the spheroid pattern of the cataractous lens (a). The lesion had high internal reflectivity (a-c) with a softly undulating surface (b) without any calcification in it.
case_images: cop-2023-0014-0001-531527_F03.jpg
case_images: PMC10601821_02_cop-2023-0014-0001-531527_F03.jpg
case_images: F3
case_images: In January 2021, UBM showed a big ring-shaped ciliary body mass (Fig. 3a-c).