case_images: PMC3362615_01
case_images: Tests performance summary.. Footnote: Immunofluorescence antibody test (IFAT), Enzyme linked immunosorbent assay (ELISA), Immunoblotting (BLOT), direct agglutination test (DAT) and polymerase chain reaction (PCR) in whole blood, standard deviation (SD), 95% confidence interval (95% CI), *standard error (SE). * SE is a measure of precision and it is not a measure of confidence interval, which is shown in sROC plot, except for ELISA.
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case_images: PMC3362615_01_pntd.0001665.g003.jpg
case_images: pntd-0001665-g003
case_images: Figure 3. For DOR analysis, the global accuracy of DAT 36.01 (9.95-130.29, I2 = 0) and Blot 27.51 (9.27-81.66, I2 = 56) was comparable and higher than IFAT 7.43 (3.08-1791, I2 = 11) and ELISA 3.06 (0.71-13.10, I2 = 87), in spite of wide confidence intervals.
case_images: Estimates of sensitivity and specificity (95% confidence interval) of tests.. Footnote: Combined results are shown using both options: fixed and random effects model. When both results are similar with low heterogeneity, both can be used. When they are different, we prefer results from random effects model, which gives wide and conservative confidence interval for heterogeneous results.
case_images: pntd.0001665.g004.jpg
case_images: PMC3362615_01_pntd.0001665.g004.jpg
case_images: pntd-0001665-g004
case_images:  Figures 4 show the results of individual and combined sensitivity and sensitivity estimates for the tests including all studies.
case_images: sROC curve for PCR in peripheral whole blood.
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case_images: PMC3362615_01_pntd.0001665.g005.jpg
case_images: pntd-0001665-g005
case_images:  Figure 5 shows performance for PCR in peripheral blood through a sROC curve.