case_images: PMC10229244_01
case_images: Mammographic aspect of the right breast tumoral mass:BIRADS score of 5.
case_images: CRIPA2023-1101130.001.jpg
case_images: PMC10229244_01_CRIPA2023-1101130.001.jpg
case_images: fig1
case_images: We present the case of a 44-year-old female patient presented to the General Surgery Department of "Saint Andrew" County Clinical Emergency Hospital of Constanta with a right mammary mass, previously identified on a unilateral digital mammography (Figure 1).
case_images: Microscopic aspect and immunohistochemical stainings of the intraepithelial tumoral proliferation: (a) HE x200; (b) ER x200; (c) PR x200; (d) CK7 x200; (e) HER2 x200; (f) S100 x200; (g) MelanA x200; (h) GATA3 x200; (i) Ki-67 x200.
case_images: CRIPA2023-1101130.002.jpg
case_images: PMC10229244_01_CRIPA2023-1101130.002.jpg
case_images: fig2
case_images: The neoplastic proliferation mainly respected a nested, occasionally tubular, pattern, associating isolated tumoral cells (Figure 2(a)). The intraepithelial neoplastic component revealed positive immunostaining for estrogen receptor (90% of the malignant cellular population; Figure 2(b)), progesterone receptor (40% of the malignant cellular population; Figure 2(c)), CK7 (Figure 2(d)). Diversely, HER2 had a negative reaction (score 0) in the intraepidermal neoplastic population (Figure 2(e)), fact supported by the in situ hybridization molecular tests that displayed a nonamplified HER2 status. MelanA/MART1 (Figure 2(g)), with positive internal control:dermal and intraepidermal melanocytes:were detected. Moreover, GATA3 displayed a positive reaction in the intraepidermal tumoral cells (Figure 2(h)). Ki-67 revealed a positive nuclear reaction of moderate intensity in 75% (hotspot) of the intraepithelial neoplastic proliferation (Figure 2(i)).