case_images: PMC9706088_01
case_images: PMC9706088_02
case_images: Images from 2008. Fundus photos of the right (A) and left (B) eyes reveal bilateral cystoid changes in the macula. A round yellowish subretinal lesion inferior to the macula of the left eye is also shown (B). Optical coherence tomography of the right (C) and left (D) eyes reveals the splitting of retinal layers and foveal neurosensory retinal detachment with cystic changes. Subretinal hyperreflectivity lesion is also noted in the left eye (B). Fluorescein angiography of the right eye (E) reveals multiple hyperfluorescent dots on the temporal macula. A round hyperfluorescent lesion is shown inferior to the macula of the left eye (F), corresponding to the subretinal lesion visualized in (B). Indocyanine green angiography of the left eye verified new vessels in the early (G) and late (H) phases.
case_images: fgene-13-1045145-g001.jpg
case_images: PMC9706088_02_fgene-13-1045145-g001.jpg
case_images: F1
case_images: FA, and indocyanine green angiography (ICGA) (Figure 1). Full-field electroretinogram (ERG) was nearly normal, but the P1 response density of the multifocal electroretinogram (mfERG) in ring 1 (macular area) was abnormal (Table 1).
case_images: Images from 2021. Fundus photos of the right (A) and left (B) eyes reveal bilateral cystoid changes in the macula and bilateral pigmented lesion inferior to the macula. Optical coherence tomography (OCT) of the right (C) and left (D) eyes shows foveal retinoschisis with enlarged cysts presently when compared to back then in 2008 (Figures 1C, D) and "shaggy" photoreceptors in the subretinal space. Focal choroidal excavation is detected in the left eye (D). Hyperreflectivity lesion in the RPE layer (C) corresponding to inactive macular neovascularization (MNV) is detected and confirmed by OCTA (E) (white arrow). Fundus autofluorescence (F,G) shows bilateral cystic changes in the macula and symmetric annular area of hyperfluorescence, suggesting retinal pigment epithelium (RPE) aberration in the posterior pole which extends nasal to the disc in both eyes mingled with subretinal deposits are present. Laser spots are distributed in the temporal peripheral retina in the right eye.
case_images: fgene-13-1045145-g002.jpg
case_images: PMC9706088_02_fgene-13-1045145-g002.jpg
case_images: F2
case_images: Inactive macular neovascularization (MNV) was visualized inferior to the right macula on optical coherence tomography angiography (OCTA) (Figure 2).