case_images: PMC8272663_01
case_images: Fluid-attenuated inversion recovery images (FLAIR) showed a "dirty CSF" appearance in the right parietal region ((a), white arrow). Axial (b) and sagittal (c) T1-weighted images after the intravenous administration of gadolinium-chelate revealed a focal area of superficial contrast enhancement overlying the cerebral cortex, presumably representing a thickened pia mater.
case_images: CRINM2021-9898364.001.jpg
case_images: PMC8272663_01_CRINM2021-9898364.001.jpg
case_images: fig1
case_images: Fluid-attenuated inversion recovery images (FLAIR) showed a "dirty CSF" appearance in the right parietal region (Figure 1(a), white arrow). Axial (Figure 1(b)) and sagittal (Figure 1(c)) T1-weighted images after the intravenous administration of gadolinium-chelate revealed a focal area of superficial contrast enhancement overlying the cerebral cortex, presumably representing a thickened pia mater and opacification of the left mastoid.
case_images: During readmission five months after the initial referral, consecutive CT scans showed multiple right-sided cerebral haemorrhages, the largest being located precentrally in the frontal lobe ((a), para-axial nonenhanced). CT angiography examination ((b), para-axial MPR) showed multiple tortuous, engorged pial veins of the right hemisphere. Cerebral angiography confirmed the presence of a suspected superficial dural arteriovenous fistula ((c), lateral projection of right internal carotid artery injection, large black arrow) in the right parietal region. The arterial feeders were mainly meningeal branches originating from the right ophthalmic artery and transosseous feeders from the right superficial temporal and occipital arteries ((d), lateral projection right external carotid artery injection); in addition, there was limited arterial supply to the fistula from the left middle meningeal artery, across the midline (not shown). Venous drainage was through a large, right temporal draining vein (large white arrow), with reflux into multiple tortuous, superficial frontotemporal veins, as shown in Figure 2(b), indicating a fistula with a high risk of haemorrhage. Comparison of axial T2-weighted images of MRI examinations at initial admittance (e) and at the second admission (f) showed the new finding of dilated pial veins (encircled), demonstrating the de novo development of the dural AV fistula.
case_images: CRINM2021-9898364.002.jpg
case_images: PMC8272663_01_CRINM2021-9898364.002.jpg
case_images: fig2
case_images: CT scans showed multiple right-sided cerebral haemorrhages, with the largest located precentrally in the frontal lobe with small perilesional parietal and temporal haemorrhages accompanied by a left hemiparesis and aphasia (Figure 2(a)). CT angiography examination (Figure 2(b), para-axial MPR) showed multiple tortuous, engorged pial veins of the right hemisphere. Cerebral angiography confirmed the presence of a suspected superficial dural arteriovenous fistula (Figure 2(c), lateral projection of right internal carotid artery injection, large black arrow) in the right parietal region. The arterial feeders were mainly meningeal branches originating from the right ophthalmic artery and transosseous feeders from the right superficial temporal and occipital arteries (Figure 2(d), lateral projection right external carotid artery injection); in addition, there was limited arterial supply to the fistula from the left middle meningeal artery across the midline (not shown). Venous drainage was through a large, right temporal draining vein (large white arrow) with reflux into multiple tortuous, superficial frontotemporal veins, as shown in Figure 2(b), indicating a fistula with high risk of haemorrhage.
case_images: Histopathology of the excised dura with lymphocytic inflammatory remnants around a damaged venous sinus (a). In the upper part of the vessel wall (see also insert (b)) there is granulation tissue with many newly formed capillaries, lymphocytes, macrophages (thick arrow), a few eosinophils (thin black arrow) and some iron debris (thin open arrow). (Haematoxylin-Eosin Staining, bar = 1 mm; asterisk = peripheral blood).
case_images: CRINM2021-9898364.003.jpg
case_images: PMC8272663_01_CRINM2021-9898364.003.jpg
case_images: fig3
case_images: Microscopy of the resected dura showed a previously damaged vein with inflammatory remnants and granulation tissue in its wall (Figures 3(a) and 3(b)).