case_images: PMC10963405_01
case_images: MRI of the patient's brain. (A) Slightly hypo signal on T1WI. (B) Slightly higher signal intensity on T2WI. (C) sagittal view. (D, E) On enhanced scan, the nodules were significantly enhanced, and the lesions grew along the ventricular wall casting.
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case_images: Imaging examination (December 24, 2020): Head enhanced Magnetic Resonance Imaging (MRI) ( Figure 1 ) showed irregular nodular shadows in the intracranial pineal region, septum pellucidum, lateral ventricle and suprasellar cistern, the larger one was about 16 x16 mm in size, and the lesion grew cast along the ventricular wall; the bilateral ventricle and third ventricle revealed hydrops; the septum pellucidum showed dilatation.
case_images: Postoperative pathological images of the tumor x200.
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case_images: Postoperative pathological immunohistochemical markers ( Figure 2 ): SALL4 (+), CD117 (+), OCT4 (+), D2-40 (+), CD30, GFAP, S-100, Syn, LCA, AFP and CYP-3 were all negative, and Ki67 labeling index was about 80%, which was diagnosed as germinoma.
case_images: Bone marrow aspirate smear showed the evidence of hemophagocytosis; original magnification x1000.
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case_images: PMC10963405_01_fonc-14-1264926-g003.jpg
case_images: f3
case_images: Bone marrow aspiration ( Figure 3 ): grade III myelodysplasia, a few cells of multiple lineage abnormal development, easy to see hemophagocytic cells.