case_images: PMC10214097_01
case_images: Photographs of a patient with cervical and submental lymphadenopathy.
case_images: 10.1177_2050313X231175720-fig1.jpg
case_images: PMC10214097_01_10.1177_2050313X231175720-fig1.jpg
case_images: fig1-2050313X231175720
case_images: On physical examination, the patient was alert, had finger clubbing, and had several mobile, firm, unmated lymph nodes in the submandibular (Figure 1), cervical, supraclavicular, axillary, and inguinal regions.
case_images: Thoraco-abdominal CT scan:mediastinal, hilar, and cervical lymphadenopathy (left);
  apical and basal consolidation, left lower lobe consolidation and left moderate
  pleural effusion, lymph node biopsy:necrotizing inflammation (right).
case_images: 10.1177_2050313X231175720-fig2.jpg
case_images: PMC10214097_01_10.1177_2050313X231175720-fig2.jpg
case_images: fig2-2050313X231175720
case_images: Left lower lobe consolidation, right apical and basal consolidation, a moderate pleural effusion on the left paraaortic, mesenteric, iliac, and inguinal lymph node enlargement with calcification in the center were evident (Figure 2).
case_images: Histopathology of Castleman's disease displaying thickened mantle zones with
  lymphocytes arranged in layers:"onion skin appearance" H&E staining; low power
  (20x) original magnification (a); intermediate power (100x) original magnification (b
  and c); lymph node follicle surrounded by mantle zone composed of concentric rings of
  small lymphocytes, H&E staining, 40x original magnification (d).
case_images: 10.1177_2050313X231175720-fig3.jpg
case_images: PMC10214097_02_10.1177_2050313X231175720-fig3.jpg
case_images: fig3-2050313X231175720
case_images: Histopathology of incisional biopsy from the neck mass demonstrated a reactive lymph node highlighting prominent vascular proliferation and hyalinization of the vessel walls (Figure 3(c)), and follicle surrounded by mantle zone composed of concentric rings of small lymphocytes with onion skin like skin appearance (Figure 3(d)).
case_images: PMC10214097_02
case_images: Histopathology of Castleman's disease displaying thickened mantle zones with
  lymphocytes arranged in layers:"onion skin appearance" H&E staining; low power
  (20x) original magnification (a); intermediate power (100x) original magnification (b
  and c); lymph node follicle surrounded by mantle zone composed of concentric rings of
  small lymphocytes, H&E staining, 40x original magnification (d).
case_images: 10.1177_2050313X231175720-fig3.jpg
case_images: PMC10214097_02_10.1177_2050313X231175720-fig3.jpg
case_images: fig3-2050313X231175720
case_images: Histopathology of incisional biopsy from the neck mass demonstrated a reactive lymph node highlighting prominent vascular proliferation and hyalinization of the vessel walls (Figure 3(c)), and follicle surrounded by mantle zone composed of concentric rings of small lymphocytes with onion skin like skin appearance (Figure 3(d)).