case_images: PMC10811408_01
case_images: Mammography, ultrasonography, and magnetic resonance imaging (MRI) demonstrating the left breast tumor. a Mammography revealed a well-defined and high-concentration mass. b Ultrasonography scans exhibited an intracystic 10 mm mass under the left nipple without enlarged axillary lymph nodes. c MRI demonstrated a 7 mm intense early enhancement in the left breast.
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case_images: F1
case_images: Mammography revealed a well-defined high-concentration mass (Fig. 1a). Ultrasonography revealed an intracystic mass measuring 10 mm under the left nipple without enlarged axillary lymph nodes (Fig. 1b). Magnetic resonance imaging revealed a 7 mm intense early enhancement in the left breast (Fig. 1c).
case_images: Pathology of core needle biopsy. a Hematoxylin and eosin stains revealed small round cancer cells. It is unknown whether there was infiltration at this time. b CK14 expression was negative for cancer cells.
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case_images: F2
case_images: A core needle biopsy revealed a ductal carcinoma with nuclear grade 1, excluding an invasive carcinoma (Fig. 2).
case_images: Pathology of mastectomy. a Hematoxylin and eosin stains revealed multiple circumscribed solid nodules and intervening small round delicate fibrovascular cores without surrounded fibrous capsule. b The cancer cells infiltrated into stromal tissue. c CD56 expression was negative. d Chromogranin A expression was negative. e Synaptophysin expression was negative.
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case_images: F3
case_images: The pathology revealed a 7-mm invasive solid papillary carcinoma (Fig. 3a) with a high hormone receptor level and no human epidermal growth factor receptor 2. The neuroendocrine markers were all negative, including CD56, chromogranin A, and synaptophysin, confirming the SPC pure type with invasion (Fig. 3b-e).