case_images: PMC8081640_01
case_images: The tumour showing mixed morphologic features with haphazardly arranged, irregularly shaped glands enmeshed in fibrotic stroma typical of cholangiocarcinoma (a) as well as sheet-like growth of solid cell nests and trabeculae showing morphologic and immunohistochemical evidence of hepatocellular differentiation (b).
case_images: CRIHEP2021-6654229.001.jpg
case_images: PMC8081640_01_CRIHEP2021-6654229.001.jpg
case_images: fig1
case_images: The cirrhotic liver contained a 1.5 cm firm white tumor that showed morphologic and immunohistochemical features of a combined hepatocellular-cholangiocarcinoma (Figure 1).
case_images: PMC8081640_02
case_images: The tumour composed of variably sized nests and trabeculae associated with desmoplasia (arrow) and hemorrhage. (a) High-grade tumour cells containing enlarged, hyperchromatic nuclei with relatively scant cytoplasm extensive necrosis. (b) The high-grade areas are positive for cytokeratin-7 and show patchy staining for arginase and Hepar-1.
case_images: CRIHEP2021-6654229.002.jpg
case_images: PMC8081640_02_CRIHEP2021-6654229.002.jpg
case_images: fig2
case_images: The carcinoma showed hepatocellular differentiation as well as undifferentiated components (Figure 2).
case_images: PMC8081640_03
case_images: This hepatocellular carcinoma containing broad trabaculae of tumour cells with abundant clear cytoplasm (a). Other high-grade areas resembling conventional hepatocellular carcinoma (b).
case_images: CRIHEP2021-6654229.003.jpg
case_images: PMC8081640_03_CRIHEP2021-6654229.003.jpg
case_images: fig3
case_images: Most (>80%) of the tumor cells contained abundant clear cytoplasm with some higher grade areas (Figure 3).
case_images: PMC8081640_04
case_images: Sheets of tumour cells arranged in cystically dilated glands (a) that contain brightly eosinophilic secretions reminiscent of colloid (b).
case_images: CRIHEP2021-6654229.004.jpg
case_images: PMC8081640_04_CRIHEP2021-6654229.004.jpg
case_images: fig4
case_images: Sheets of tumor cells were arranged in large, cystically dilated glands filled with eosinophilic material reminiscent of colloid seen in thyroid follicles (Figure 4).
case_images: PMC8081640_05
case_images: Infiltrating malignant glands are intimately associated with a dense lymphoid infiltrate (a). Intraepithelial lymphocytes are also present (b) ().
case_images: CRIHEP2021-6654229.005.jpg
case_images: PMC8081640_05_CRIHEP2021-6654229.005.jpg
case_images: fig5
case_images: The malignant glands were associated with a dense lymphoid infiltrate and tumor-infiltrating lymphocytes (Figure 5).