case_images: PMC5362925_01
case_images: Magnetic resonance images of the thoracolumbar area of the cat reported, showing a heterogeneous, intramedullary ill-defined area, hyperintense on T2-weighted images from the T12 to L5 vertebral levels: (a) FSET2-weighted image (sagittal plane); (b) FSE T2-weighted image (transverse plane at the level of L2). The star indicates the described abnormal area, whereas the arrow marks the T13 vertebra
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case_images: T1-weighted and hyperintense on STIR and T2-weighted images was visualised extending from the T12 to L5 vertebral levels (Figure 1a,b). There was no enhancement after the administration of gadolinium.
case_images: Lumbar spinal cord segment. Deposition of hyaline material (arrows) and associated calcium concretion (arrow head) in the wall of leptomeningeal arterial blood vessels. The endothelial cells show hypertrophic changes (haematoxylin and eosin, x 20)
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case_images: This lesion was associated with arteriolar hyalinosis (Figure 2), occasional extravascular or intravascular calcification and mild neutrophilic infiltration.
case_images: L1 spinal cord segment. Severe haemorrhagic leucomalacia in the dorsal funiculi. Note the thrombus tail in the ventral spinal artery (arrow) (haematoxylin and eosin, x 1.5)
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case_images: At the L4 spinal cord segment, an occluding thrombus of the ventral spinal artery was found (Figure 3).
case_images: Marked immunoreaction for smooth muscle actin (SMA) expressed by endothelial cells of leptomeningeal blood vessels. One is also affected by hyalinosis (arrow) (immunohistochemistry, ABC method [DakoCytomation], SMA antibody, x 20)
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case_images: fig4-2055116915589840
case_images: Immuno-histochemistry performed on a 5 microm fresh frozen paraffin-embedded section (ABC method; DakoCytomation) using mouse monoclonal antismooth muscle actin (SMA) (1:50; clone 1A4 [Dako]) and diaminobenzidine as chromogene showed a strong positivity in intimal cells of leptomeningeal blood vessels lacking of thrombotic events (Figure 4).