case_images: PMC10492564_01
case_images: Changes in the nails of patients after treatment with durvalumab at the same time and at different angles. (A) The ten fingers of both hands. (B) The right thumb. (C) The five fingers of the right hand. (D) The five fingers of the left hand.
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case_images: April 2022 (22 months after first administration of durvalumab), the patient presented with an adverse reaction of the fingernails of both hands, albeit with no pain (Figure 1). Antifungal cream was used, but the pigmentation and thickening of the nails did not improve, the patient also experienced skin peeling and scaling on his hands, which improved with lubricating ointment (Figure S1).
case_images: Hematoxylin-eosin (HE) staining (A), periodic acid-Schiff staining (PAS) (B), and periodic acid-silver methenamine (PASM) staining (C) of nail keratinocytes and fibrous connective tissue on the bottom of the fingernails.
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case_images: PAS and PASM staining showed no fungal infection (Figures 2 and S2).