case_images: PMC10701531_01
case_images: PMC10701531_02
case_images: PMC10701531_03
case_images: PMC10701531_04
case_images: (A) The lower limb skin change of Case 4. (B) The Pedigree diagram of the proband and corresponding sequencing results. Circles represent female family members, squares represent male family members, and the black small circle represents a single heterozygous mutation in the HAVCR2 gene. The Sanger sequencing map shows the corresponding mutations in the HAVCR2 gene for the proband [c245A>G (p.Y82C) and c.141C>A (p.A47L) compound heterozygous mutations] and their family members (with single heterozygous mutation). The red arrow represents the mutation site.
case_images: fimmu-14-1271324-g001.jpg
case_images: PMC10701531_04_fimmu-14-1271324-g001.jpg
case_images: f1
case_images: Figure 1A ), accompanied by a decrease in blood counts. Further laboratory tests indicated a decrease in The family lineage survey map is depicted in  Figure 1B .
case_images: PMC10701531_05