case_images: PMC10601805_01
case_images: Abdominal ultrasound showing a distended gallbladder filled with intraluminal heterogeneous material (a), histological examination of surgical specimen showing the gallbladder and the tumor with melanocytic pigments (b), immunohistochemistry staining positive for S100 in the tumor and negative in the glands (c), and negative for CKAE1AE3 in the tumor and positive in the glands (d).
case_images: cro-2023-0016-0001-534147_F01.jpg
case_images: PMC10601805_01_cro-2023-0016-0001-534147_F01.jpg
case_images: F1
case_images: An abdominal ultrasound showed a distended gallbladder (approximately 6 cm wide and 11 cm long) with hydrops due to intraluminal heterogeneous material (shown in Fig. 1a). Pathological report found an 8 cm endoluminal necrotic mass compatible with a mutated BRAF V600E melanoma (shown in Fig. 1b-d).
case_images: Dermoscopy of suspected primary cutaneous melanoma on the patient's back (1 cm in its long axis).
case_images: cro-2023-0016-0001-534147_F02.jpg
case_images: PMC10601805_01_cro-2023-0016-0001-534147_F02.jpg
case_images: F2
case_images: Dermatologic examination revealed a small lesion (1 cm in its long axis) on the patient's back (shown in Fig. 2).
case_images: Palpable supra-umbilical mass (a), positron emission tomography scan showing a 18F-fluorodeoxyglucose-avid (sub-)cutaneous lesion in the supra-umbilical trocar site (b).
case_images: cro-2023-0016-0001-534147_F03.jpg
case_images: PMC10601805_01_cro-2023-0016-0001-534147_F03.jpg
case_images: F3
case_images: Six weeks after surgery and 3 weeks after the first course of Pembrolizumab, the patient noticed a palpable supra-umbilical mass (shown in Fig. 3a). A repeated positron emission tomography scan revealed an 18F-fluorodeoxyglucose avid (sub-)cutaneous lesion in the supra-umbilical trocar site (the one used to extract the gallbladder during laparoscopic surgery) (shown in Fig. 3b).