case_images: PMC11347415_01
case_images: (A-D) Patient's upper and lower limbs upon initial presentation with thick, violaceous, hyperkeratotic plaques with a Wickham's striae. (E, F) Lesions on the patient's hands after 2 weeks of systemic steroid therapy.
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case_images: PMC11347415_01_fphar-15-1445685-g001.jpg
case_images: F1
case_images: Terminology Criteria for Adverse Events) grade 2 drug-induced lichen-planus-like reaction presented at that time with eruption of confluent, flat-topped erythematous papules distributed on upper and lower extremities. The dorsal surfaces of the hands and feet were the most affected areas, exhibiting thick, violaceous, hyperkeratotic plaques with a white, lace-like pattern on the surface (Wickham's striae) (Figures 1A-D). Subsequently, she received 40 mg of prednisone for 2 weeks, resulting in partial improvement (Figures 1E,F).
case_images: Thickened epidermis with focal parakeratosis, acanthosis and thickening of the granular layer. In the basal layer there is a damage by adjacent, band-like infiltration of small lymphocytes. (H&E staining, magnification x 10).
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case_images: F2
case_images: Histology (biopsy taken from the back of hand) was consistent with lichenoid eruption, showing thickened epidermis with focal parakeratosis, acanthosis and thickening of the granular layer, in the basal layer there was a damage by adjacent, band-like infiltration of small lymphocytes (Figure 2).
case_images: Evolution of clinical events and skin changes. ALND, axillary lymph node dissection; AC, anthracycline-doxorubicine; PXL, paclitaxel.
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case_images: F3
case_images: The timeline of this cutaneous adverse reaction and partial skin healing process are summarized in Figure 3.