case_images: PMC10539605_01
case_images: Timeline of our case's treatment for advanced squamous cell carcinoma.
case_images: fonc-13-1188772-g001.jpg
case_images: PMC10539605_01_fonc-13-1188772-g001.jpg
case_images: f1
case_images: The best response was stable disease (SD) ( Figure 1 ).
case_images: Pathological findings. (A) 3 January 2017, the pathological result was squamous cell carcinoma of non-small cell lung cance. (B) 17 January 2018, the pathological result was still lung squamous cell carcinoma.
case_images: fonc-13-1188772-g002.jpg
case_images: PMC10539605_01_fonc-13-1188772-g002.jpg
case_images: f2
case_images: T790M mutation was found after genetic testing of specimen acquired by pathological puncture ( Figure 2 ). Then the patient was admitted to the hospital for radiotherapy of the lower lobe of the right lung and metastatic lymph nodes, DT = 6000 cGy (200 cGy dose per time).
case_images: Images from computed tomography showing the tumor in the right lung in response to therapy. (A) Before therapy, imaging was performed on 30 December 2016. (B) Six months after taking gefitinib on 18 August 2017. (C) Resistance progresses on 20 January 2018. (D) After the radiotherapy on 5 June 2018. (E) One year after taking Osimertinib on 18 February 2019. (F) Last check on 20 May 2022.
case_images: fonc-13-1188772-g003.jpg
case_images: PMC10539605_01_fonc-13-1188772-g003.jpg
case_images: f3
case_images: After taking Osimertinib for more than 4 years, the primary lesion in the right lung was well controlled ( Figure 3 ) and the brain metastases almost disappeared ( Figure 4 ).
case_images: MRI images of brain metastases. (A, B) Before therapy, imaging performed on 30 December 2016. (C, D) One year after taking gefitinib on 19 March 2018. (E, F) One year after taking Osimertinib on 18 February 2019. (G, H) Last check on 20 May 2022.
case_images: fonc-13-1188772-g004.jpg
case_images: PMC10539605_01_fonc-13-1188772-g004.jpg
case_images: f4
case_images: After taking Osimertinib for more than 4 years, the primary lesion in the right lung was well controlled ( Figure 3 ) and the brain metastases almost disappeared ( Figure 4 ).