case_images: PMC10601798_01
case_images: Photograph of the left eye upon admission, showing a large, diffuse, fleshy hemorrhagic mass in the left bulbar conjunctiva.
case_images: cop-2023-0014-0001-532106_F01.jpg
case_images: PMC10601798_01_cop-2023-0014-0001-532106_F01.jpg
case_images: F1
case_images: On slit-lamp examination, a large, diffuse, elevated, dark-reddish fleshy mass was visualized over the left bulbar conjunctiva, along with areas of subconjunctival hemorrhage sparing the superior bulbar and palpebral conjunctiva (shown in Fig. 1).
case_images: Hematoxylin-eosin-stained sections of the KS biopsy tissue. a Low-magnification microscopic image showing a spindle cell variant of conjunctival squamous epithelium with dispersed red blood cells (original magnification, x40). b, c Higher magnification images showing mildly atypical spindle cells forming slit-like, blood-filled channels and red blood cells extravasating into the surrounding stroma (original magnification, x100 and x200, respectively). d Section with plump spindle cells and extravasated red blood cells, a few inflammatory cells, and hemosiderin deposition (original magnification, x400). e Spindle cell proliferation with intervening vascular spaces and prominent lymphoplasmacytic infiltration. Stratified squamous epithelium of the conjunctiva is seen in the left upper corner of the image (original magnification, x400).
case_images: cop-2023-0014-0001-532106_F02.jpg
case_images: PMC10601798_01_cop-2023-0014-0001-532106_F02.jpg
case_images: F2
case_images: Histopathological examination of the biopsied tissue revealed proliferation of spindle-shaped endothelial cells, slit-like formations, and numerous extravasated red blood cells and inflammatory cells, consistent with KS (shown in Fig. 2).
case_images: Immunohistochemical staining of the KS biopsy sections. a Positive CD31 immunoreactivity. b Positive CD34 immunoreactivity. CD31 and CD34 immunoreactivity confirmed the endothelial cell origins of the KS. c Positive HHV-8 immunostaining distinguishing the KS from other vascular tumors.
case_images: cop-2023-0014-0001-532106_F03.jpg
case_images: PMC10601798_01_cop-2023-0014-0001-532106_F03.jpg
case_images: F3
case_images: Immunohistochemical staining (shown in Fig. 3) strongly supported the diagnosis of KS.
case_images: Photograph of the left eye showing total resolution of KS following HAART and local radiotherapy.
case_images: cop-2023-0014-0001-532106_F04.jpg
case_images: PMC10601798_01_cop-2023-0014-0001-532106_F04.jpg
case_images: F4
case_images: The lesion resolved completely in response to the local irradiation, and only mild redness, without any fibrosis or ocular range of motion restrictions, was observed at the 8-month follow-up (shown in Fig. 4).