case_images: PMC4360725_01
case_images: a Rarefaction of tubules and glomeruli, severe interstitial inflammatory infiltrates and fibrosis (arrow), PAS x10. b Interstitial nephritis with dense lymphoplasmacytic infiltrations and eosinophils (arrows), PAS x400. c The majority of interstitial inflammatory infiltrates were IgG-producing plasma cells (arrows). Immunohistochemistry for IgG, x400. d The majority (>40%) of IgG+ plasma cells appear positive for IgG4 (arrows). In absolute numbers, >50 IgG4+ plasma cells are seen per hpf. Immunohistochemistry for IgG4, x400. e Focal thickening of GBMs with C4d positivity indicating MN lesions. Immunohistochemistry for C4d, x200. f Electron microscopy revealed the presence of subepithelial (arrows) and scarce mesangial deposits compatible with secondary MN, x15.000.
case_images: cnd-0005-0044-g01.jpg
case_images: PMC4360725_01_cnd-0005-0044-g01.jpg
case_images: F1
case_images: CD3+ and CD20+ lymphocytes and eosinophils (fig. 1). Congo red stain was negative.