case_images: PMC9485595_01
case_images: Ultrasound images of the patient. (A, B): Grayscale ultrasound showed hypoechoic mass in the pancreatic parenchyma (orange arrow) and hypoechoic masses partially filled in the splenic vein (red arrow).In the arterial phase, contrast-enhanced US (CEUS) showed iso-enhancement to slight hypo-enhancement [(C), orange arrow)]; In the venous phase, CEUS showed hypo-enhancement [(D), orange arrow].
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case_images: Medical Solutions; Mountain View, CA, United States) equipped with a C5-1 abdominal convex transducer (frequency range of 1-5 MHz). Conventional ultrasound demonstrated an abnormal shape, large volume and uneven parenchymal echo of the pancreas. Meanwhile, three hypoechoic lesions were found at the head of the pancreas, the junction of the body and the tail of the pancreas, and the tail of the pancreas, with sizes of approximately 3.3x3.1 cm, 2.4x2.1 cm and 5.4x2.8 cm, respectively ( Figures 1A, B ). Hypoechoic masses partially filled in the splenic vein behind the pancreatic body ( Figure 1B ). Italy) suspension was injected through the left cubital vein followed by a flush with 5 ml saline. In the CEUS, all of these lesions showed iso-enhancement to slight hypo-enhancement in the arterial phase ( Figure 1C ) and hypo-enhancement in the venous phase ( Figure 1D ).
case_images: Contrast-enhanced computed tomography images of the patient. Contrast-enhanced computed tomography showed both hypo-enhancement masses in the arterial phase [(A), orange arrow)] and venous phase [(B), orange arrow)].
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case_images: Postoperative histopathological images of the patient. (A) Hematoxylin and eosin staining showed some cytoplasm with deep brownish-black granules (magnification, x 400). Immunohistochemical staining displayed S100(+) (B), Human Melanoma Black 45(+) (C) and MART-1(+) (magnification, x 400) (D).
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case_images: PMC9485595_01_fonc-12-989638-g003.jpg
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case_images: Postoperative pathology confirmed a malignant tumor of the pancreas and some cytoplasm with deep brownish-black granules ( Figure 3A ), which invaded the fat, nerves and blood vessels outside the pancreas. Immunohistochemically, the tumor cells were positive for melanocytic marker S-100 ( Figure 3B ), Human Melanoma Black 45 ( Figure 3C ) and MART-1( Figure 3D ).