case_images: PMC10510334_01
case_images: Initial presentation of a sebaceous cyst like sebaceoma.
case_images: acc-10-03-10255-g001.jpg
case_images: PMC10510334_01_acc-10-03-10255-g001.jpg
case_images: f1
case_images: A 67-year-old Caucasian man presented to his general practitioner in June 2020 with a long-standing skin lesion on his right upper back (Figure 1).
case_images: (A) Dermal nodule (HE, x20); (B) Dermal nodule consisting of >50% basaloid cells (left) and mature sebocytes (right) (HE, x40). (C) Mismatch repair enzymes showing loss of MSH2 (IHC, Anti-MSH2 Ab, x40); (D) Mismatch repair enzymes showing normal staining for MLH1 (IHC, Anti-MLH1 Ab, x40).
case_images: acc-10-03-10255-g002.jpg
case_images: PMC10510334_01_acc-10-03-10255-g002.jpg
case_images: f2
case_images: Immunochemistry for Mismatch Repair (MMR) proteins showed a loss of MSH2 and MSH6, consistent of an allelic variant of Lynch Syndrome (Figure 2).
case_images: Hepatic flexure adenocarcinoma during colonoscopy.
case_images: acc-10-03-10255-g003.jpg
case_images: PMC10510334_01_acc-10-03-10255-g003.jpg
case_images: f3
case_images: A hepatic flexure adenocarcinoma was identified (Figure 3).