case_images: PMC2590677_01
case_images: PMC2590677_02
case_images: PMC2590677_03
case_images: CT and PET scans of EBV-related SMN of liver. CT scan of the abdomen and pelvis (8/05) from Patient 3 revealed multiple masses, mainly in the right lobe and involving segment 4. The largest mass measured 6.8 x 5.8 cm and was located in the right inferior lobe (a). FDG-PET (9/05) demonstrated areas of hypermetabolism in the inferior aspect of the right hepatic lobe (SUV max 5.7), and two other neighboring foci (SUV max 5) (b).
case_images: SRCM2008-859407.001.jpg
case_images: PMC2590677_03_SRCM2008-859407.001.jpg
case_images: fig1
case_images: Positron emission tomography (PET) scan (9/05) showed tracer uptake in the liver lesions (Figure 1).
case_images: Gross
  and microscopic findings from EBV-related SMN of liver. Liver specimen from
  Patient 3 measured 17 x 13.2 x 7.6 cm. Four nodules were found, ranging in size
  from 0.4 cm to 6.7 cm (a). Histologic features on H&E staining included
  moderate increased cellularity (with areas containing rounder, less fusiform
  cells), lack of nuclear pleomorphism, and a low mitotic rate (1 mitotic
  figure/50 high-powered field) (b). Nearly all cells were positive for
  EBV-EBER by ISH, although intensity of the staining varied from cell to cell (c). Electron microscopy revealed spindle cells with abundant cytoplasmic
  aggregates of actin microfilaments, including fusiform dense bodies and
  attachment plaques, confirming the diagnosis of a well-differentiated smooth
  muscle proliferation (d).
case_images: SRCM2008-859407.002.jpg
case_images: PMC2590677_03_SRCM2008-859407.002.jpg
case_images: fig2
case_images: SMNs (Figure 2). She remains without disease as of October 2008.