case_images: PMC11371449_01
case_images: MRI of right shoulder: preradiotherapy treatment in the frontal plane.
case_images: CRIONM2024-5782352.001.jpg
case_images: PMC11371449_01_CRIONM2024-5782352.001.jpg
case_images: fig1
case_images: The contrast-enhanced MRI (Figure 1) revealed a sizable, well-defined, encapsulated mass superior to the right shoulder girdle, measuring 147 x 192 x 135 mm (AP x ML x SI).
case_images: CT planning of tumour in sagittal, frontal, and transverse planes.
case_images: CRIONM2024-5782352.002.jpg
case_images: PMC11371449_01_CRIONM2024-5782352.002.jpg
case_images: fig2
case_images: Staging using CT (Figure 2) with whole-body FDG PET (Figure 3) indicated a mildly metabolically active liposarcoma, with no evidence of metabolically active metastatic disease.
case_images: Tumour staging via FDG-PET in sagittal and frontal planes.
case_images: CRIONM2024-5782352.003.jpg
case_images: PMC11371449_01_CRIONM2024-5782352.003.jpg
case_images: fig3
case_images: Staging using CT (Figure 2) with whole-body FDG PET (Figure 3) indicated a mildly metabolically active liposarcoma, with no evidence of metabolically active metastatic disease.
case_images: Haematoxylin-eosin stain. (a) x400 magnification. Viable tumour composed of variably sized adipocytes and scattered pleomorphic spindle cells in fibromyxoid stroma. (b) x100 magnification. Tumour includes necrotic area with reduced cellularity. (c) x40 magnification. Dedifferentiated liposarcoma showing discrete areas of nonadipocytic sarcomatous components (stained pink).
case_images: CRIONM2024-5782352.004.jpg
case_images: PMC11371449_01_CRIONM2024-5782352.004.jpg
case_images: fig4
case_images: Although occasional mitotic figures and scattered mononuclear inflammatory cells were observed, there was an overall reduction in cellularity by%-50-60% (Figure 4).
case_images: Fluorescence in situ hybridization. The CytoOrange fluorochrome signals are the 3' end of DDIT3 and the CytoGreen signals are the 5' end of DDIT3 gene. (a) Demonstrates duplication of DDIT3 gene in low level. (b) DDIT3 break-apart probe (MetaSystems) showing evidence of gain of DDIT3 but no evidence of gene rearrangement. (c) FUS break-apart probe (MetaSystems) showing no evidence of FUS gene rearrangement.
case_images: CRIONM2024-5782352.005.jpg
case_images: PMC11371449_01_CRIONM2024-5782352.005.jpg
case_images: fig5
case_images: In this patient's case, FISH analysis revealed a gain of the DDIT3 gene, resulting in three copies within the 12q13.3 region (Figure 5).