case_images: PMC6485059_01
case_images: Chronological relationships of antibiotic treatment, vitamin K1 administration, surgical procedures, and coagulation time fluctuation of the patient. APTT prolonged activated partial thromboplastin time, PBD post-burn day, PT prothrombin time
case_images: 41038_2019_150_Fig1_HTML.jpg
case_images: PMC6485059_01_41038_2019_150_Fig1_HTML.jpg
case_images: Fig1
case_images: Broad-spectrum antibiotics, Meropenem  (1.0 g three times daily), was applied intravenously since PBD 3 as the empirical therapy for extensive burn patients and continued for ensured Pseudomonas aeruginosa-positive of the wound in this patient (Fig. 1). APTT improved to 47 s and came back to the normal range on PDB 39 along with normal value of coagulation factor II, VII, IX, and X (Figs. 1 and 4), even with combined usage of tigecycline (0.5 g three times daily) and fosfomycin sodium (4.0 g three times daily) intravenously, started on PBD 38, dealing with multi-resistant strain of Klebsiella pneumonia (tigecycline resistant). Another two operations were performed for grafting on PBD 40 and 52.
case_images: Daily maximal temperature and heart rate (HR) of the patient during his stay in hospital. PBD Post-burn day
case_images: 41038_2019_150_Fig2_HTML.jpg
case_images: PMC6485059_01_41038_2019_150_Fig2_HTML.jpg
case_images: Fig2
case_images: Not until PBD 13 did the patient show the signs of infection, such as chill, high fever, wounds infiltration, delirium, and neutrocytosis (Figs. 2 and 3), while his hemodynamic status remained stable, all coagulation criteria within normal range.
case_images: Infection related indicators (blood cell count and Precalcitonin (PCT)) levels of the patient during his stay in hospital. PBD Post-burn day, PLT Platelet, WBC White blood cell
case_images: 41038_2019_150_Fig3_HTML.jpg
case_images: PMC6485059_01_41038_2019_150_Fig3_HTML.jpg
case_images: Fig3
case_images: Not until PBD 13 did the patient show the signs of infection, such as chill, high fever, wounds infiltration, delirium, and neutrocytosis (Figs. 2 and 3), while his hemodynamic status remained stable, all coagulation criteria within normal range.
case_images: Coagulation factor level fluctuation of the patient before and during his treatment of hypocoagulation. PBD Post-burn day
case_images: 41038_2019_150_Fig4_HTML.jpg
case_images: PMC6485059_01_41038_2019_150_Fig4_HTML.jpg
case_images: Fig4
case_images: APTT improved to 47 s and came back to the normal range on PDB 39 along with normal value of coagulation factor II, VII, IX, and X (Figs. 1 and 4), even with combined usage of tigecycline (0.5 g three times daily) and fosfomycin sodium (4.0 g three times daily) intravenously, started on PBD 38, dealing with multi-resistant strain of Klebsiella pneumonia (tigecycline resistant). Another two operations were performed for grafting on PBD 40 and 52.
case_images: Relationship between intravenous vitamin K1, meropenem, fosfomysin sodium, tigecycline, and levels of factors related to hypocoagulopathy. Meropenem, 1.0 g three times daily; tigecycline, 0.5 g three times daily; fosfomycin sodium, 4.0 g three times daily. PBD post-burn day
case_images: 41038_2019_150_Fig5_HTML.jpg
case_images: PMC6485059_01_41038_2019_150_Fig5_HTML.jpg
case_images: Fig5
case_images: The patient was discharged on PBD 67 with all burn wounds recovered and no abnormality in coagulation status (Fig. 5).