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case_images: A-C, Hypotrichosis in the 15-year-old patient. Similar presentation is found in the 13-year-old patient. A, Diffuse decrease in the hair density over the scalp. B, Dermatoscopy shows spars thin hair of the left eyebrow with eyebrows tattoo. C, Thin spars eyelashes.
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case_images: They were well until the age of few months, when they started to have gradual decrease in the density of scalp and body hair, as well as loss of eyebrows and eyelashes (Fig 1).
case_images: Dermatoscopy showed thick curved nail plate of the right side of the big toenail in the 15-year-old girl.
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case_images: The 15-year-old female and the 13-year-old male developed skin fragility, nail dystrophy (Fig 2), and lacrimal duct obstruction at the age of 2 years, without respiratory or urinary symptoms.
case_images: Hyperkeratotic papules on bilateral shins in 15-year-old girl.
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case_images: The skin fragility in the eldest was in the form of itchy erythematous papules and plaques that appeared over both upper and lower extremities (Fig 3).
case_images: Right pretibial erythematous atrophic patch with intact blister in 13-year-old boy.
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case_images: Her brother presented with a blister on his right shin following minor trauma, that healed, leaving an erythematous atrophic patches with central erosion and crust (Fig 4).