case_images: PMC10940509_01
case_images: (A) MRI image shows C3/C4 vertebral bodies and their right attachments presented bone destruction with soft tissue mass. (B) CT image shows a mass measure 3.5 cmx3.9 cm in the right lower lobe. (C) Bone scan image shows multiple bone metastases. (D) Fine needle aspiration biopsy show adenocarcinoma.
case_images: fonc-14-1278245-g001.jpg
case_images: PMC10940509_01_fonc-14-1278245-g001.jpg
case_images: f1
case_images: C3/C4 vertebral bodies and their right attachments presented bone destruction with soft tissue mass by cervical spine MRI ( Figure 1A ). T1WI slightly low signal, T2WI slightly high signal, and DWI high signal ( Figure 1A ). Enhanced chest computed tomography revealed an irregular moderate enhancement soft tissue mass measuring 3.5 cmx3.9 cm in the right lower lobe of the lung with adjacent pleural thickening and pulling ( Figure 1B ). Additionally, osteolytic bone destruction was observed at the left edge of the sternum ( Figure 1B ). The radionuclide bone scan revealed multiple bone metastases, including 4th cervical vertebral body, the left sternoclavicular joint, sternum, sacrum, and the right sacroiliac joint ( Figure 1C ). Percutaneous lung fine needle aspiration pathology revealed adenocarcinoma ( Figure 1D ).
case_images: (A) CT image shows a mass measure 1.1 cmx1.4 cm in the middle cavernous body of penile with proximal urethral dilation. (B) MRI image shows a mass measure 1.2 cmx1.3 cm in the middle cavernous body of penile with local urethral stricture. (C) Electronic cystoscope image shows urethra was crushed. (D-F) During operation a fused nodule was found on the right side of the corpus cavernosum.
case_images: fonc-14-1278245-g002.jpg
case_images: PMC10940509_01_fonc-14-1278245-g002.jpg
case_images: f2
case_images: A mass located in the middle cavernous body of penile measuring 1.1 cmx1.4 cm was detected by pelvic CT ( Figure 2A ). Local urethral stricture and proximal urethral dilation (widest diameter about 1.5 cm) were observed ( Figure 2A ). A heterogeneously enhancing mass located in the middle cavernous body of penile measuring 1.2 cmx1.3 cm was also detected by pelvic MRI ( Figure 2B ). Local urethral stricture and proximal urethral dilation were observed ( Figure 2B ). The anterior urethra was crushed and narrowed by the tumor when the electronic cystoscope enters the urethra at a 6 cm distance ( Figure 2C ). One fused nodule was found on the right of corpus cavernosum penis with urethral invasion ( Figures 2D-F ).
case_images: (A) Histopathological images of the nodule of corpus cavernosum penis show adenocarcinoma from primary lung cancer. H&E staining was performed. Immunohistochemical staining revealed that the tumor cells were positive for CK, TTF-1, NapsinA, CK7, Ki-67, and were negative for P40, and P63. Representative images are shown at x200 magnification. (B) Histopathological images of the nodule of corpus spongiosum show adenocarcinoma from primary lung cancer. H&E staining was performed. Immunohistochemical staining revealed that the tumor cells were positive for CK, TTF-1, NapsinA, CK7, and were negative for GATA-3, P40, and P63. Representative images are shown at x200 magnification. (C) Timeline of the patient's diagnosis and treatment process.
case_images: fonc-14-1278245-g003.jpg
case_images: PMC10940509_01_fonc-14-1278245-g003.jpg
case_images: f3
case_images: CK(+), TTF-1(+), NapsinA(+), CK7(+), Ki-67(+, 10%), P40 (-), P63 (-) ( Figure 3A ), and the histological diagnosis of the nodule of corpus cavernosum urethra was poorly differentiated adenocarcinoma with CK(+), TTF-1(+), NapsinA(+), CK7(+), GATA-3(-), P40(-), P63(-) ( Figure 3B ), which indicated that the penile metastasis from adenocarcinoma of lung. Currently, the patient was remaining on treatment ( Figure 3C ).