case_images: PMC8477373_01
case_images: (A, B) Skin lesions on admission.
case_images: fimmu-12-731774-g001.jpg
case_images: PMC8477373_01_fimmu-12-731774-g001.jpg
case_images: f1
case_images: The blood bullae were big, loose, and easy to break, forming the erosive surface (Figures 1A, B), and accompanied by itchy and obvious pain.
case_images: Skin pathology: (A) H&E, x200; (B) H&E, x400.
case_images: fimmu-12-731774-g002.jpg
case_images: PMC8477373_01_fimmu-12-731774-g002.jpg
case_images: f2
case_images: Histopathological findings showed epidermal hyperplasia and edema, subepidermal blister formation, numerous eosinophils in the blister, and obvious eosinophil infiltration around the superficial dermis vessels (Figures 2A, B).
case_images: IgG immunoglobulin deposits along the dermo-epidermal junction.
case_images: fimmu-12-731774-g003.jpg
case_images: PMC8477373_01_fimmu-12-731774-g003.jpg
case_images: f3
case_images: Immunofluorescence was positive for IgG (Figure 3) and C3 (Figure 4).
case_images: C3 deposits along the dermo-epidermal junction.
case_images: fimmu-12-731774-g004.jpg
case_images: PMC8477373_01_fimmu-12-731774-g004.jpg
case_images: f4
case_images: Immunofluorescence was positive for IgG (Figure 3) and C3 (Figure 4).
case_images: (A, B) Skin lesions on the 8th day after glucocorticoid treatment.
case_images: fimmu-12-731774-g005.jpg
case_images: PMC8477373_01_fimmu-12-731774-g005.jpg
case_images: f5
case_images: All the superficial erosions were scabby and most of the scabs fell off, leaving dark red pigmentation spots (Figures 5A, B).
case_images: Bullous pemphigoid reappearance after steroid tapering and continuous therapy for 5 months; skin of left hip joint.
case_images: fimmu-12-731774-g006.jpg
case_images: PMC8477373_01_fimmu-12-731774-g006.jpg
case_images: f6
case_images: So far (in July 2021), the skin lesions were not healed (Figure 6), the dose of methylprednisolone was reduced to 25 mg/day, and the monitored BP180 was in the normal range.