case_images: PMC11140069_01
case_images: PMC11140069_02
case_images: NMMHC-IIA localization in neutrophils from the patient. (A,B) May-Grunwald-Giemsa-stained peripheral blood smear images of the patient. Dohle-like body (arrow) and giant platelet as large as red blood cells (arrowhead) (A) Dohle-like body (arrow). Scale bars = 10 microm (B). (C) An immunofluorescence micrograph of a neutrophil immunostained with anti-NMMHC-IIA antibody. Small aggregates (<0.7 microm) with less than 11 in number are shown (arrows).
case_images: fped-12-1391742-g001.jpg
case_images: PMC11140069_02_fped-12-1391742-g001.jpg
case_images: F1
case_images: Examination of peripheral blood films (May-Grunwald-Giemsa stain) by light microscopy showed giant platelets and Dohle-like inclusions in neutrophils (Figures 1A,B). Immunofluorescence analysis (IFA) for the NMMHC-IIA revealed small aggregates (<0.7 microm), less than 11 in number, predicting mutations in motor domain of MYH9 gene (Figure 1C).