case_images: PMC9276994_01
case_images: An ultrasound scan showing severe polyhydramnios with a single DVP of 13.9 cm at 30 weeks and 2 days.
case_images: fmed-09-870503-g0001.jpg
case_images: PMC9276994_01_fmed-09-870503-g0001.jpg
case_images: F1
case_images: At 30 weeks + 2 days, a follow-up ultrasound scan showed significant polyhydramnios with an AFI of 35 cm and a single DVP of 13.9 cm (Figure 1).
case_images: An ultrasound scan showing an AFI of 24.1 cm at 31 weeks 2 days.
case_images: fmed-09-870503-g0002.jpg
case_images: PMC9276994_01_fmed-09-870503-g0002.jpg
case_images: F2
case_images: One week later, the AFI decreased from 35 to 24.1 cm (Figure 2), while the DA diameter significantly decreased from 3.8 to 3.1 mm (corresponding to the 1st centile).
case_images: An ultrasound scan shows DA diameter at 31 weeks 6 days (3.57 mm, 6th centile).
case_images: fmed-09-870503-g0003.jpg
case_images: PMC9276994_01_fmed-09-870503-g0003.jpg
case_images: F3
case_images: Four days later, the AFI increased to 28 cm, while the DA diameter increased to 3.57 mm [corresponding to the 6th centile (Figure 3)].
case_images: An ultrasound scan showing findings at 34 weeks + 2 days (A): AFI of 45.9 cm. (B): Umbilical artery Doppler waveform with increased PI above the 99th centile.
case_images: fmed-09-870503-g0004.jpg
case_images: PMC9276994_01_fmed-09-870503-g0004.jpg
case_images: F4
case_images: AFI at 45.9 cm (Figure 4A). At that point, the umbilical artery pulsatility index (PI), which was previously normal, increased considerably to 1.38 (Reference range 0.60-1.28 at 34 weeks, i.e., above the 99th centile) (Figure 4B). A summary of the changes in AFI and DA diameter in response to indomethacin dose adjustments is shown in Figure 5.
case_images: A summary diagram to outline changes in AFI and DA diameter during the antenatal indomethacin therapy of the patient.
case_images: fmed-09-870503-g0005.jpg
case_images: PMC9276994_01_fmed-09-870503-g0005.jpg
case_images: F5
case_images: At that point, the umbilical artery pulsatility index (PI), which was previously normal, increased considerably to 1.38 (Reference range 0.60-1.28 at 34 weeks, i.e., above the 99th centile) (Figure 4B). A summary of the changes in AFI and DA diameter in response to indomethacin dose adjustments is shown in Figure 5.
case_images: PMC9276994_02