case_images: PMC8192200_01
case_images: (a) Liver biopsy (H&E, x40) showing bridging necrosis and collapse of parenchyma with cholestasis and sparse inflammatory infiltrate rich in lymphocytes and plasma cells ((b) inset x200). (c) A trichrome stain (x20) showing lack of fibrosis supporting acute nature of the illness.
case_images: CRIHEP2021-5512883.001.jpg
case_images: PMC8192200_01_CRIHEP2021-5512883.001.jpg
case_images: fig1
case_images: Liver biopsy showed cholestatic hepatitis with areas of resolving necrosis (Figure 1).
case_images: (a) Renal biopsy showing tubular casts comprising of hemoglobin (hemoglobin immunostained (b)) and bile pigment (Fouchet stained (c)). Glomeruli and vasculature were within normal limits.
case_images: CRIHEP2021-5512883.002.jpg
case_images: PMC8192200_01_CRIHEP2021-5512883.002.jpg
case_images: fig2
case_images: Renal biopsy showed acute tubular injury with bilirubin and hemoglobin casts (Figure 2).
case_images: Changes in AST, ALT, LDH, and T-Bil during hospitalization are plotted from admission at days 1-25.
case_images: CRIHEP2021-5512883.003.jpg
case_images: PMC8192200_01_CRIHEP2021-5512883.003.jpg
case_images: fig3
case_images: Over the next few weeks, patient's liver functions test and hemolysis labs steadily improved (Figures 3 and 4).
case_images: Changes in INR, hemoglobin, and reticulocyte counts during hospitalization are plotted from admission at days 1-25.
case_images: CRIHEP2021-5512883.004.jpg
case_images: PMC8192200_01_CRIHEP2021-5512883.004.jpg
case_images: fig4
case_images: Over the next few weeks, patient's liver functions test and hemolysis labs steadily improved (Figures 3 and 4).