case_images: PMC4323713_01
case_images: Indurated erythematous-ferruginous plaque with central atrophic scars (from
  previous biopsies) on the lateral side of the right leg
case_images: abd-90-01-0128-g01.jpg
case_images: PMC4323713_01_abd-90-01-0128-g01.jpg
case_images: f01
case_images: A 63-year-old female patient had an indurated, infiltrated erythematous-ferruginous plaque with central atrophic scars (from previous biopsies) on her right leg (Figure 1).
case_images: Ulcer with irregular borders and center with areas of necrosis and fibrin on the
  lateral side of the right leg
case_images: abd-90-01-0128-g02.jpg
case_images: PMC4323713_01_abd-90-01-0128-g02.jpg
case_images: f02
case_images: We repeated the biopsy and the lesion progressed to a 6-cm ulcer with irregular borders and fibrino-necrotic areas (Figure 2).
case_images: H.E. Areas of granulation tissue with foci of lymphocytic inflammatory infiltrate
  and associated fibrosis are seen in the dermis
case_images: abd-90-01-0128-g03.jpg
case_images: PMC4323713_01_abd-90-01-0128-g03.jpg
case_images: f03
case_images: The anatomicopathological study showed histiocytes and multinucleated giant cells (Figure 3).
case_images: Electrophoresis in agarose gel of the PCR products. Lane M, molecular weight
  marker (100 bp ladder); lane 1, PCR product obtained from the patient s sample
  (positive for M. tuberculosis). Lane 2, positive control (M. tuberculosis); lane
  3, negative control
case_images: abd-90-01-0128-g04.jpg
case_images: PMC4323713_01_abd-90-01-0128-g04.jpg
case_images: f04
case_images: TB1 (primers: TB1 (5'-CCTGCGAGCGTAGGCGTCGG-3') and TB2 (5'-CTCGTCCAGCGCCGCTTCGG-3')), which amplify a fragment of 123 base-pairs (bp) of the IS6110 sequence (Figure 4). The treatment was performed with pyrazinamide, rifampicin, isoniazid and ethambutol.