case_images: PMC11750875_01
case_images: Gastroscopy images. (A) Dentate line. (B) Esophagus. (C) Fundus of the stomach. (D) Gastric body. (E) Gastric angle. (F) Duodenum.
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case_images: Gastroscopy indicated the presence of a large, irregular mass measuring approximately 4.5 cm in diameter located in the fundus of the cardia ( Figure 1 ).
case_images: Computed tomography of gastric tumor before and after neoadjuvant therapy. (A) CT of the irregular mass with dimensions of 6.3*5.0 cm before neoadjuvant therapy. (B) CT of irregular thickening on the gastric fundus and the range is obviously regressed compared to before.
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case_images: f2
case_images: Additionally, multiple enlarged lymph nodes were observed surrounding the stomach and within the lesser omental sac, all demonstrating uniform enhancement ( Figure 2A ). The patient subsequently underwent three cycles of neoadjuvant therapy, resulting in significant tumor and lymph node regression as shown by enhanced CT ( Figure 2B ).
case_images: Completely resected tumor and histopathological findings. (A) Complete resected tumor. (B) histopathological findings of gastric tumor.
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case_images: f3
case_images: Sectioning of the tumor revealed a tough brown and gray mass that had invaded the muscle layer, lacking clear demarcation from the surrounding structures ( Figure 3A ). Subsequent immunohistochemical analysis demonstrated positivity for Her2, while P63 and CK5/6 were negative ( Figure 3B ).
case_images: The whole treatment chart with the AFP trend.
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case_images: f4
case_images: The serum AFP level was 5.63 ng/mL ( Figure 4 ).