case_images: PMC515307_01
case_images: Solitary lesion over dorsum of left index finger.
case_images: 1471-5945-4-9-1.jpg
case_images: PMC515307_01_1471-5945-4-9-1.jpg
case_images: F1
case_images: Skin lesions consisted of scattered, white to skin-colored papules, less than 1 centimeter in diameter, and with central protrusion, that were distributed on the dorsum of fingers (Fig 1), forearms (Fig 2), distal portion of the thighs and on the calves (Fig 3).
case_images: An anetodermic lesion on forearm.
case_images: 1471-5945-4-9-2.jpg
case_images: PMC515307_01_1471-5945-4-9-2.jpg
case_images: F2
case_images: Skin lesions consisted of scattered, white to skin-colored papules, less than 1 centimeter in diameter, and with central protrusion, that were distributed on the dorsum of fingers (Fig 1), forearms (Fig 2), distal portion of the thighs and on the calves (Fig 3).
case_images: An anetodermic lesion on lateral aspect of left lower leg (before cryotherapy)
case_images: 1471-5945-4-9-3.jpg
case_images: PMC515307_01_1471-5945-4-9-3.jpg
case_images: F3
case_images: Skin lesions consisted of scattered, white to skin-colored papules, less than 1 centimeter in diameter, and with central protrusion, that were distributed on the dorsum of fingers (Fig 1), forearms (Fig 2), distal portion of the thighs and on the calves (Fig 3).
case_images: Anetoderma lesions some minute after cryotherapy
case_images: 1471-5945-4-9-4.jpg
case_images: PMC515307_01_1471-5945-4-9-4.jpg
case_images: F4
case_images: We tried to treat the patient with liquid nitrogen cryotherapy by means of cotton-tip applicator for two freeze-thaw cycles (freeze time, 10-15 seconds), in 6-8 sessions weekly; which obtained moderate improvement in some early-onset lesions with no frank atrophy (Fig 4 and 5).
case_images: The same view as Fig. 4 after several sessions of cryotherapy (the 2 lower lesions near completely been resolved).
case_images: 1471-5945-4-9-5.jpg
case_images: PMC515307_01_1471-5945-4-9-5.jpg
case_images: F5
case_images: We tried to treat the patient with liquid nitrogen cryotherapy by means of cotton-tip applicator for two freeze-thaw cycles (freeze time, 10-15 seconds), in 6-8 sessions weekly; which obtained moderate improvement in some early-onset lesions with no frank atrophy (Fig 4 and 5).
case_images: Faintly eosinophilic separated collagen bundles in upper dermis (H&E x250).
case_images: 1471-5945-4-9-6.jpg
case_images: PMC515307_01_1471-5945-4-9-6.jpg
case_images: F6
case_images: Haematoxylin and eosin stained section showed faintly eosinophilic separated collagen fibers in the upper and mid-dermis (Fig 6).
case_images: Severely decreased elastic fibres in superficial and mid dermis (Verhoeff-van Gieson stain x250).
case_images: 1471-5945-4-9-7.jpg
case_images: PMC515307_01_1471-5945-4-9-7.jpg
case_images: F7
case_images: Elastic fibres around the vessels in the affected areas are also fragmented and markedly decreased (Fig 7,8).