case_images: PMC3970455_01
case_images: Optiray contrast-enhanced computed tomography images of the chest with sagittal (a) and coronal (b) reconstructions in the 14-year-old proband revealing aneurysmal dilation of the ascending aorta.
case_images: CRIG2014-591516.001.jpg
case_images: PMC3970455_01_CRIG2014-591516.001.jpg
case_images: fig1
case_images: Computed tomography scan ruled out the presence of an aneurysmal rupture or dissection but revealed a fusiform aneurysmal dilatation of the ascending aorta with greatest dimensions of the ascending aorta of 4.1 cm (AP) x 4.4 cm (RL) (Figures 1(a) and 1(b)).
case_images: (a) Ascending aorta: medial fibrosis and dystrophic calcification (Hematoxylin and Eosin) and (b) fragmentation and disorganization of the elastic fibers (Verhoeff Van Gieson's elastic stain).
case_images: CRIG2014-591516.002.jpg
case_images: PMC3970455_01_CRIG2014-591516.002.jpg
case_images: fig2
case_images: Additionally, the aorta showed dystrophic calcification (Figures 2(a) and 2(b)).
case_images: PMC3970455_02
case_images: Sanger sequencing chromatogram revealing the pathogenic SMAD3 mutation, c.3G>A (p. Met1Ile) in the proband versus the normal sequence in a control.
case_images: CRIG2014-591516.003.jpg
case_images: PMC3970455_02_CRIG2014-591516.003.jpg
case_images: fig3
case_images: Met1Ile) (Figure 3).