case_images: PMC11807390_01
case_images: Clinical, radiological, and histopathological findings of a large malignant thyroid tumor with skull infiltration and intracranial extension. A and B: Depiction of a patient with a 15x10 cm mass on the left fronto-orbital region showing apparent ipsilateral ocular involvement. . C:  Contrast CT demonstrates a large tumor mass measuring 85x76.6x91 mm, infiltrating the bone tables of the left fronto-orbital skull and the major wing of the sphenoid.. D: Contrast CT shows a solid, hypervascular, infiltrative lesion involving the calvarium in the left frontal region, causing compressive effect on the ipsilateral frontal parenchyma, with slight midline deviation and collapse of the frontal horn of the lateral ventricle. Significant thick peripheral enhancement is observed after administering the contrast agent.. E: Illustrates a malignant epithelial tumor originating from the thyroid, with oval nuclei cells and intranuclear inclusions infiltrating the bone tissue of the skull (40x microscopy, H&E).. F: Shows antigenic expression of thyroglobulin (40x microscopy, Immunohistochemistry).
case_images: cureus-0017-00000077234-i01.jpg
case_images: PMC11807390_01_cureus-0017-00000077234-i01.jpg
case_images: FIG1
case_images: In the thyroid region, the enlarged left lobe was palpated, with no evident signs of focalization or neurological deficit (Figure 1a-1b). The CAT report of the skull showed the presence of a lesion with a neoplastic appearance, with well-defined contours measuring 85x76.6x91 mm (a previous study from one year earlier showed a lesion measuring 65x65x60 mm), centered in the left frontal bone with compressive effect on the left frontal parenchyma, infiltrative involvement of the orbital roof and likely extending to the ipsilateral dural (Figure 1c-1d). Findings confirmed follicular variant of papillary thyroid carcinoma (Figure 1e-1f).