case_images: PMC5635450_01
case_images: PMC5635450_02
case_images: PMC5635450_03
case_images: (
  A) Family pedigree marked with progressive phenotypes. (
  B) Secondary structure of HSD11B2 marked with major domains and the p.R337C amino acid position. (
  C) Capillary sequencing chromatogram representation of p.R337C variation in the family; arrow and asterisks marks depict the variation loci and affected individuals respectively.
case_images: f1000research-5-13312-g0000.jpg
case_images: PMC5635450_03_f1000research-5-13312-g0000.jpg
case_images: f1
case_images: The index patient is the eldest (30 years old) and the brother mentioned (28 years old) is the second of five siblings, the others being females aged 22, 18 and 14 years old ( Figure-1A).