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case_images: (a) Assessment of gene mutation probability and (b) family tree analysis. Source: Dordic-Crnogorac, Marija. "Family tree analysis." 12 Nov. 2022, accessed 27 Jan. 2023. Source: Dordic-Crnogorac, Marija. "Assessment of the patient's probability of having a BRCA gene mutation, BRCAPRO." 12 Nov. 2022, accessed 27 Jan. 2023.
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case_images: PMC11101246_05_CRIONM2024-6699698.001.jpg
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case_images: Nevertheless, the carrier probability (CP) was recalculated in BRCAPRO (Figure 1(a)) which showed almost 100% CP for BRCA genes. However, besides CP calculation and high burden of breast cancers in the family (Figure 1(b); the mother was diagnosed with bilateral breast cancer (age 28 and age 48) and the grandmother was diagnosed with the breast cancer at the age of 36), the high probability of LFS was established during the pretest genetic counselling session because of the complex personal medical history.
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