case_images: PMC11366704_01
case_images: Depiction of chest imaging over the course of treatment. (A) Chest CT scan on February 20 showing an infection in the left upper lobe. (B) Bedside chest radiograph on February 23 exhibiting diffuse pulmonary infiltration, necessitating veno-venous extracorporeal membrane oxygenation (V-V ECMO) support due to a decrease in oxygenation index despite 100% oxygen support. (C) Bedside chest radiograph on March 5 demonstrating significant absorption of pulmonary infiltrates following tailored antimicrobial and immunotherapeutic interventions, allowing for the removal of endotracheal intubation. The depicted timeline reflects the dynamic pulmonary pathology and the impact of medical interventions, correlating with the patient's clinical course from severe infection through to stabilization and recovery.
case_images: fmed-11-1393540-g002.jpg
case_images: PMC11366704_01_fmed-11-1393540-g002.jpg
case_images: F2
case_images: The brain MRI did not reveal significant abnormalities (data not shown), but a chest CT scan revealed an infection in the left upper lobe (Figure 2A). Bedside chest radiographs showed diffuse pulmonary infiltration (Figure 2B). On March 2, ECMO support was withdrawn; by March 5, pulmonary lesions were significantly absorbed, and endotracheal intubation was removed (Figure 2C).
case_images: Comparative analysis of IgG and IgM antibody levels over time. The figure presents a bar chart comparing the levels of IgG (blue) and IgM (red) antibodies at various time points, indicating the progression and response to treatment in the patient over time.
case_images: fmed-11-1393540-g003.jpg
case_images: PMC11366704_01_fmed-11-1393540-g003.jpg
case_images: F3
case_images: April 2022, during readmission, IgG titers had decreased, with three experiments showing titers at 1:80 and two experiments at 1:160, while IgM titers were recorded as 1:20 in all five experiments. At the one-year follow-up, both IgG and IgM antibody titers were considered negative (Figure 3).