case_images: PMC10749167_01
case_images: Skin photographs and chest images from an anti-MDA5-positive ADM patient with early-stage ILD before extended-release Tof treatment. Reddish-purple discoloration around the eyelids with swelling (heliotrope rash) (A) and erythematous area on the upper back and posterior neck (shawl sign) (B). Bilateral diffuse infiltration with ground-glass opacity (GGO) on high-resolution chest CT (C and D) at the diagnosis of ILD. Arrows indicate the GGO infiltration.
case_images: ITT-12-187-g0001.jpg
case_images: PMC10749167_01_ITT-12-187-g0001.jpg
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case_images: A 39-year-old local woman visited the outpatient rheumatology clinic with a 1-month history of reddish-purple discoloration around the eyelids with swelling (heliotrope rash, Figure 1A), and erythematous areas on the upper back and posterior neck (shawl sign, Figure 1B), as well as on the front of the chest (V sign), followed by dry cough and mild dyspnea for 1 week. Despite normal predicted FVC and diffusion capacity, high-resolution chest CT demonstrated bilateral ground-glass opacity (GGO) in the lungs (Figure 1C and D).
case_images: Skin photographs and chest images from an anti-MDA5-positive ADM patient with early-stage ILD after extended-release Tof treatment. Resolved heliotrope rash (A) and shawl sign (B). Resolved bilateral diffuse infiltration with GGO on high-resolution chest CT (C and D).
case_images: ITT-12-187-g0002.jpg
case_images: PMC10749167_01_ITT-12-187-g0002.jpg
case_images: f0002
case_images: She had resolved respiratory symptoms and cutaneous manifestations (Figure 2A and B), while the use of CS was discontinued, 5 months after initiating Tof therapy. Follow-up CT displayed complete resolution of bilateral pulmonary GGO infiltration (Figure 2C and D). 