case_images: PMC10556511_01
case_images: Computed tomography images, ensartinib dose, and blood test results. CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9; SCC, squamous epithelial cell carcinoma antigen; NT-proBNP, N-terminal brain natriuretic peptide precursor; ALT, alanine transaminase; AST, aspartate transaminase; pH, potential of hydrogen; PaCO2, partial pressure of carbon dioxide; PaO2, partial pressure of oxygen; CRP, C-reactive protein; WBC, white blood cell count; Hb, hemoglobin; PLT, platelet count.
case_images: fonc-13-1235679-g001.jpg
case_images: PMC10556511_01_fonc-13-1235679-g001.jpg
case_images: f1
case_images: Emphysema and microscopic nodules were present in the left upper lung and right lower lung ( Figure 1 ). A repeat CT examination of his chest 1.5 months later showed that the lung mass had grown (5.9 x 5.4 cm) and that the sub-rhomboid lymph nodes had become enlarged ( Figure 1 ). At follow-up on 13 April 2023, the tumor was stable but had slightly increased in size (5.3 x 5.5 cm) ( Figure 1 ).
case_images: Pathology and magnetic resonance imaging. (A) Hematoxylin-eosin. (B) Cytokeratin 5/6 (+). (C) Epidermal growth factor receptor (+). (D) Cytokeratin 7 (+). (E) Ki67 (+, 60%). (F) p40 (few+). (G) p53 (+++). (H) Pan-cytokeratin (+). (I) Thyroid transcription factor-1 (few +). (J) Napsin A (few +). (K) T1-weighted imaging. (L) Fluid-attenuated inversion recovery. (M) T2-weighted imaging.
case_images: fonc-13-1235679-g002.jpg
case_images: PMC10556511_01_fonc-13-1235679-g002.jpg
case_images: f2
case_images: Enhanced magnetic resonance imaging on 5 October 2022 showed no tumor metastasis in brain ( Figures 2K-M ). 10 October 2022 (combination of hematoxylin-eosin staining and immunohistochemistry) showed non-small cell carcinoma. The immunohistochemical results were as follows: carcinoembryonic antigen (-), cytokeratin 5/6 (+), epidermal growth factor receptor (EGFR) (membrane +), cytokeratin 7 (+), Ki-67 (+, 60%), p40 (few +), p53 (3+), pan-cytokeratin (+), thyroid transcription factor-1 (few +), napsin A (few +), cytokeratin 20 (-), and GATA-3 (+) ( Figures 2A-J ).