case_images: PMC4052065_01
case_images: A submucosal swelling of the left subglottic trachea (arrow) by fiberscopic examination.
case_images: CRIOT2014-503497.001.jpg
case_images: PMC4052065_01_CRIOT2014-503497.001.jpg
case_images: fig1
case_images: The laryngeal mucosa did not appear to have an ulcerative or hemorrhagic lesion (Figure 1).
case_images: MRI revealed the same findings as CT scanning: (a) a low-intensity area on T1-weighted images and (b) a nonhomogenous high-intensity area on T2-weighted images. (c) The tumor demonstrates high intensity on a postgadolinium contrast T1 image (arrow).
case_images: CRIOT2014-503497.002.jpg
case_images: PMC4052065_01_CRIOT2014-503497.002.jpg
case_images: fig2
case_images: T1-weighted images (Figure 2(a)) and a nonhomogenous high-intensity area on T2-weighted images (Figure 2(b)). The images of the tumor demonstrated high intensity on a postgadolinium contrast T1 image (Figure 2(c)).
case_images: From behind, the laryngectomy specimen reveals a giant cell tumor under the intact mucosa (*). E: epiglottis, H: hyoid bone, T: trachea, VF: vocal fold, and scale bar = 3.0 cm.
case_images: CRIOT2014-503497.003.jpg
case_images: PMC4052065_01_CRIOT2014-503497.003.jpg
case_images: fig3
case_images: The interface between the tumor and the adjacent mucosa and the cartilage was clearly delineated (Figure 3).
case_images: (a) Histological examination demonstrates that the cellular mononuclear eosinophilic stromal component (arrowhead) and multinucleated osteoclast-like giant cells (arrow) were scattered throughout the lesions in an intermediate power field. Pleomorphic giant cells are absent. (b) Mitotic figures are about 6/10 HPF by the lack of cytological atypia.
case_images: CRIOT2014-503497.004.jpg
case_images: PMC4052065_01_CRIOT2014-503497.004.jpg
case_images: fig4
case_images: Histological examination revealed a cellular mononuclear eosinophilic stromal component, and multinucleated osteoclast-like giant cells were scattered throughout the lesion in an intermediate power field (Figure 4(a)). HPF by the lack of cytological atypia (Figure 4(b)). Histopathological findings yielded a diagnosis of "giant cell tumor with local invasion." The patient has been well following total laryngectomy and subsequently free of disease for two and a half years.