case_images: PMC10699217_01
case_images: Leukemia cutis as an ulcerative nodule on the right posterior forearm (a) and leukemia cutis remission 4 months after chemotherapy treatment (b)
case_images: ABR-12-222-g001.jpg
case_images: PMC10699217_01_ABR-12-222-g001.jpg
case_images: F1
case_images: According to the patient, the lesion had initially appeared as a single painless and non-itchy papule and gradually progressed to a large crusted ulcerative nodule with an erythematous border [Figure 1a]. After 4 months of the treatment initiation, the lesion resolved completely [Figure 1b] and counts were in the normal range.
case_images: Histopthology of the skin lesion showing diffuse infiltrates of small cells with rounded hyper-chromatic nuclei and scant cytoplasm (H&E stain, a: x40, b: x100)
case_images: ABR-12-222-g002.jpg
case_images: PMC10699217_01_ABR-12-222-g002.jpg
case_images: F2
case_images: The infiltrate was composed of small lymphocytes with rounded hyper-chromatic nuclei without any atypical features, indicating a lymphoproliferative disorder [Figure 2].
case_images: The immuno-histochemical examination showed that the tumor cells were strongly positive for CD5 (a), CD20 (b), and Bcl-2 (c) but negative for CD3 (d), Bcl-6 (e), and CD10 (f) (x100)
case_images: ABR-12-222-g003.jpg
case_images: PMC10699217_01_ABR-12-222-g003.jpg
case_images: F3
case_images: The result of immuno-histochemistry analysis of skin lesion biopsy was positive for CD5, CD20, and BCL2 but negative for CD3, BCL6, cyclin-D1, and C10, suggesting a small lymphocytic lymphoma (SLL) [Figure 3].