case_images: PMC10586790_01
case_images: Edema of both fingers and the dorsa of both hands and erythema on the dorsal sides of the fingers (A). On ultrasonographic examination, fluid retention around the biceps, synovitis of the biceps, and synovitis of the joint synovium and tendon sheath synovium are observed (B).
case_images: fonc-13-1260818-g001.jpg
case_images: PMC10586790_01_fonc-13-1260818-g001.jpg
case_images: f1
case_images: During the administration of nivolumab, edema of both fingers and the dorsa of both hands appeared in April 2018 ( Figure 1 ), and pitting edema of both lower legs deteriorated. On ultrasonographic examination, fluid retention around the biceps, synovitis of the biceps, and synovitis of the joint synovium and tendon sheath synovium were observed ( Figure 1 ).
case_images: Epithelial marker (pan-keratin, E-cadherin), mesenchymal marker (vimentin, SMA), collagen type I (A), and immune cell markers (CD4, CD8, CD45RA, CD68) (B) are shown. The white bar indicates 200 mum.
case_images: fonc-13-1260818-g002.jpg
case_images: PMC10586790_01_fonc-13-1260818-g002.jpg
case_images: f2
case_images: Multiplex immunostaining of skin tissue using imaging mass cytometry (Hyperion Imaging System, Fluidigm, South San Francisco, CA, USA) showed CD4+ or CD8+ T cells infiltrating the perivascular area and macrophages infiltrating the interstitium of the skin ( Figure 2 ).
case_images: After the administration of PSL, the edema of the dorsa of the hands has improved in one week.
case_images: fonc-13-1260818-g003.jpg
case_images: PMC10586790_01_fonc-13-1260818-g003.jpg
case_images: f3
case_images: After the administration of PSL, the edema of the dorsa of the hands and lower legs improved in one week ( Figure 3 ), and the shoulder joint pain resolved.