case_images: PMC10512445_01
case_images: (a) Bone marrow biopsy (a. Bone marrow hematoxylin and eosin staining x100; b. bone marrow hematoxylin and eosin staining x1,000, epithelioid granulomas. c. positive reticular fiber staining (fibrosis grade 3)). (b) Lymph node biopsy (a. Hematoxylin and eosin staining x100. b. Reed-Sternberg cells, x1,000, yellow arrow. c. CD30-positive x100. d. Epstein-Barr-negative x100. e. CD20-negative x100 f. Ki-67-positive x100).
case_images: j_biol-2022-0744-fig001.jpg
case_images: PMC10512445_01_j_biol-2022-0744-fig001.jpg
case_images: j_biol-2022-0744_fig_001
case_images: TB was positive using polymerase chain reaction (PCR). The patient was then diagnosed with skeletal TB secondary bone marrow fibrosis (Figure 1a) and began anti-TB medication for 3 months (rifapentine 0.45 g twice a week, ethambutol 0.75 g/day, isoniazid 0.3 g/day). CD45 (+/-), CD30-positive, CD21-negative, CD35-negative, S-100 (scattered positive), ALK-negative, CD68 (histiocyte positive), SMA-negative, Desmin-negative, CD1a-negative, CD15-negative, CD3-positive, CD4-positive, CD20-negative, CD56-negative, CD8-positive, CXCL-13-negative, TIA-1-positive, P53 (wild-type), perforin-negative, PAS-negative, EBV-negative and Ki-67 (+25%) (Figure 1b). Consequently, the patient was diagnosed with classic HL at stage III, skeletal TB, and acquired immunodeficiency syndrome (AIDS).
case_images: Chest CT before (a)-(c) and after (d)-(f) chemotherapy. (a) and (d) coronal, (b) and (e): sagittal, (c) and (f): axial; yellow arrow, upper right mediastinal mass.
case_images: j_biol-2022-0744-fig002.jpg
case_images: PMC10512445_01_j_biol-2022-0744-fig002.jpg
case_images: j_biol-2022-0744_fig_002
case_images: Pleural effusions gradually resolved, enlarged lymph nodes spontaneously regressed, and upper right mediastinal mass size significantly decreased (Figure 2).