case_images: PMC8463211_01
case_images: Clinical photograph showing multiple nodules on the patient's forehead.
case_images: CRIPA2021-5531820.001.jpg
case_images: PMC8463211_01_CRIPA2021-5531820.001.jpg
case_images: fig1
case_images: All lesions looked identical and described as moderately painful pink violaceous papules and nodules with irregular borders (Figure 1).
case_images: Micrograph of the forehead lesions demonstrating intense dermal-based infiltrate of foamy macrophages with sparing of skin adnexa. H&E x40.
case_images: CRIPA2021-5531820.002.jpg
case_images: PMC8463211_01_CRIPA2021-5531820.002.jpg
case_images: fig2
case_images: Histologic evaluation of the recurrent/persistent lesions revealed an intense dermal infiltrate of foamy tissue macrophages with a minor admixture of plasma cells, lymphocytes, and scattered multinucleated giant cells (see Figures 2 and 3).
case_images: Higher-power view revealed predominantly foamy tissue macrophages with a minor admixture of plasma cells, lymphocytes, and scattered multinucleated giant cells. H&E x100.
case_images: CRIPA2021-5531820.003.jpg
case_images: PMC8463211_01_CRIPA2021-5531820.003.jpg
case_images: fig3
case_images: Histologic evaluation of the recurrent/persistent lesions revealed an intense dermal infiltrate of foamy tissue macrophages with a minor admixture of plasma cells, lymphocytes, and scattered multinucleated giant cells (see Figures 2 and 3).
case_images: A close up of a different field shows a predominance of spindled cells with prominent extracellular collagen deposition.
case_images: CRIPA2021-5531820.004.jpg
case_images: PMC8463211_01_CRIPA2021-5531820.004.jpg
case_images: fig4
case_images: Other areas showed a predominance of spindled cells and associated extracellular collagen fibers (see Figure 4).
case_images: CD163 immunohistochemical study highlights the tissue macrophages. x100 magnification.
case_images: CRIPA2021-5531820.005.jpg
case_images: PMC8463211_01_CRIPA2021-5531820.005.jpg
case_images: fig5
case_images: The lesional cells were positive for CD163 (see Figure 5) and CD68 and negative for CD1a, thus confirming them to be of mononuclear-macrophage lineage.