case_images: PMC11335551_01
case_images: Chest computed tomography (CT) showing an anterior mediastinal mass (Green) and right axillary lymph node enlargement (Red).
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case_images: CT revealed an anterior mediastinal mass, bilateral subclavian lymph node enlargement, and bilateral axillary lymph node enlargement ( Figure 1 ).
case_images: Muscle biopsy of left musculus biceps brachii. (A) Hematoxylin and Eosin (HE) staining showed perifascicular atrophy of muscle fibers, and perivascular inflammatory infiltrates (x40). No regenerating muscle fibers are observed, and there is no apparent nuclear migration of muscle fibers. Immunohistochemical staining showed (B) CD4+, (C) CD68+ (x40).
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case_images: Figure 2 ), and cervical lymph node biopsy indicated nodular sclerosing HL (nsHL) ( Figure 3 ). F-fluorodeoxyglucose positron emission tomography (FDG-PET) revealed mild diffuse increases in subcutaneous FDG metabolism in the extremities, along with anterior diaphragmatic lymphadenopathy and involvement of the sternal stalk ( Figure 4 ).
case_images: Histologic images in cervical lymph node (A) staining showed typical Hodgkin Reed-Sternberg (H-RS) cells in a variable inflammatory background. (HE, x40). Immunohistochemical staining also showed (B) CD30(+), (C) CD15(+), (D) CD20(+), (E) ALK(-) (F) EBER(-) (x40).
case_images: fonc-14-1416083-g003.jpg
case_images: PMC11335551_01_fonc-14-1416083-g003.jpg
case_images: f3
case_images: Figure 2 ), and cervical lymph node biopsy indicated nodular sclerosing HL (nsHL) ( Figure 3 ). F-fluorodeoxyglucose positron emission tomography (FDG-PET) revealed mild diffuse increases in subcutaneous FDG metabolism in the extremities, along with anterior diaphragmatic lymphadenopathy and involvement of the sternal stalk ( Figure 4 ).
case_images: (A, B) FDG-PET on admission showing diffuse uptake in mediastinum supradiaphragmatic lymph nodes (Red), left supraclavicular lymph node (Yellow) and right cervical lymph nodes (Green). (C) FDG-PET at 11 months after diagnosis showing disappearance of abnormal signals.
case_images: fonc-14-1416083-g004.jpg
case_images: PMC11335551_01_fonc-14-1416083-g004.jpg
case_images: f4
case_images: Figure 2 ), and cervical lymph node biopsy indicated nodular sclerosing HL (nsHL) ( Figure 3 ). F-fluorodeoxyglucose positron emission tomography (FDG-PET) revealed mild diffuse increases in subcutaneous FDG metabolism in the extremities, along with anterior diaphragmatic lymphadenopathy and involvement of the sternal stalk ( Figure 4 ). Eleven months after the diagnosis, HL and JDM were completely in remission ( Figure 4 ).