case_images: PMC11269130_01
case_images: Computerized tomography (CT) of the liver. Multiple low-density foci were found in hepatic parenchyma.
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case_images: PMC11269130_01_fsurg-11-1348806-g001.jpg
case_images: F1
case_images: The computed tomography (CT) scan revealed the presence of cirrhosis, multiple hepatic nodules, splenomegaly, and ascites (Figure 1).
case_images: Sanger sequencing of the genes of the patient and parents. (A) Gene variant of the patient; (B) gene sequencing of the father; (C) gene sequencing of the mother.
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case_images: PMC11269130_01_fsurg-11-1348806-g002.jpg
case_images: F2
case_images: The results revealed the presence of a homozygous missense variant in the MPV17 gene c.293C>T (p.P98l) (Figure 2).
case_images: Liver morphology. (A) The whole liver tissue is a piece, the size is 12.5 x 9.2 x 5.3 cm, the section surface is gray-brown solid, and the quality is medium, showing nodular cirrhosis. (B) Microscopic examination of the structure of the liver lobules disappeared, fibrous tissue proliferation divided the liver lobules to form pseudolobules, small bile duct hyperplasia, and some hepatocyte steatosis. (C) Microscopic examination of the lobular structure of the liver disappears, hepatocyte edema, and steatosis. (D) Microscopic examination of the liver lobular structure is lost, fibrous tissue is accompanied by more lymphocyte infiltration, and gallbladder stasis can be seen. Liver pathological grading and staging showed that the inflammatory response is G2, fibrosis is S4.
case_images: fsurg-11-1348806-g003.jpg
case_images: PMC11269130_01_fsurg-11-1348806-g003.jpg
case_images: F3
case_images: Postoperative liver pathology revealed chronic hepatitis and nodular cirrhosis (Figure 3).