case_images: PMC11802423_01
case_images: Images of the patient's examination. (A) illustrates the ARMM as seen on MRI. (B) depicts the enhancement computed tomography imaging, which revealed thickening of the lower rectal wall, with no evidence of peripheral or distant metastasis. (C) shows that anoscopy detected a black mass situated at the dentate line, measuring 2.5 x 1.5 cm. (D) presents the immunohistochemical findings: S-100 (+), HMB45 (+), Melan-A (+), Ki-67 (positive rate of 50%), EGFR (+/-). (E) is an endoscopic image taken 3 months post-cryoablation.
case_images: fonc-15-1465645-g001.jpg
case_images: PMC11802423_01_fonc-15-1465645-g001.jpg
case_images: f1
case_images: Anoscopy disclosed a black mass situated at the dentate line, measuring 2.5 x 1.5 cm ( Figure 1C ). The upper rectum appeared dilated, and clinical considerations pointed towards melanoma (Stage I, according to the Slingluff staging system) ( Figure 1A ). Contrast-enhanced computed tomography (CT) imaging demonstrated thickening of the lower rectal wall, with no evidence of peripheral or distant metastasis ( Figure 1B ). ICD-O code of 8720/3. Immunohistochemical analysis yielded the following results: S-100 (+), HMB45 (+), Melan-A (+), Ki-67 (positive rate of 50%), and EGFR (+/-) (refer to  Figure 1D ).
case_images: Images taken during cryotherapy and ultrasound monitoring. (A-C) shows images of the freezing process, while (D, E) displays images of ultrasound monitoring during the freezing procedure.
case_images: fonc-15-1465645-g002.jpg
case_images: PMC11802423_01_fonc-15-1465645-g002.jpg
case_images: f2
case_images: The image in  Figure 2A  depicted the refrigeration equipment during the cryoablation process, with the cryoprobe initiating its cooling effect. Figure 2B , the tumor was enveloped by an ice ball, rendering it indiscernible to our sight.  Figure 2C  illustrated the ongoing transvaginal ultrasound monitoring following the initial freeze-thaw cycle.  Figure 2D  presented the tumor's location and dimensions (2.4 x 1.7 cm) via ultrasound imaging prior to freezing.  Figure 2E  exhibited the progressive development of the ice ball, along with the heightened echogenicity at its perimeter. Finally,  Figure 2F  demonstrated the absence of tumor blood supply on contrast-enhanced ultrasound post-cryoablation.