case_images: PMC11316487_01
case_images: Case 1 presented with recurrent pruritic PN affecting both lower limbs before abrocitinib treatment (A). Gradual and significant improvement was observed in Case 1 at week 1 (B) and week 8 (C). Case 2 presented with refractory PN on both lower extremities before abrocitinib treatment (D). The histopathology of a nodular lesion from Case 2 is shown in (E, x40; F, x100). Following the initiation of abrocitinib treatment, Case 2 also exhibited significant improvement at week 1 (G) and week 8 (H).
case_images: CCID-17-1793-g0001.jpg
case_images: PMC11316487_02_CCID-17-1793-g0001.jpg
case_images: f0001
case_images: However, her symptoms were unsuccessfully controlled, and multiple plaques and nodules recurrently appeared in the same area (Figure 1D). The pathological report demonstrated thick compact hyperkeratosis, irregular epidermal hyperplasia, parakeratosis, hypergranulosis, and a superficial infiltrate of mainly lymphocytes with papillary dermal fibrosis (Figure 1E and F). After 1 week, the patient experienced a notable improvement in both the itching sensation and the lesions (Figure 1G). By the end of 8 weeks, the symptoms, particularly the itching (NRS scores decreasing from 7 to 0), had nearly resolved, leaving only residual pigmentation (Figure 1H).
case_images: PMC11316487_02
case_images: Case 1 presented with recurrent pruritic PN affecting both lower limbs before abrocitinib treatment (A). Gradual and significant improvement was observed in Case 1 at week 1 (B) and week 8 (C). Case 2 presented with refractory PN on both lower extremities before abrocitinib treatment (D). The histopathology of a nodular lesion from Case 2 is shown in (E, x40; F, x100). Following the initiation of abrocitinib treatment, Case 2 also exhibited significant improvement at week 1 (G) and week 8 (H).
case_images: CCID-17-1793-g0001.jpg
case_images: PMC11316487_02_CCID-17-1793-g0001.jpg
case_images: f0001
case_images: However, her symptoms were unsuccessfully controlled, and multiple plaques and nodules recurrently appeared in the same area (Figure 1D). The pathological report demonstrated thick compact hyperkeratosis, irregular epidermal hyperplasia, parakeratosis, hypergranulosis, and a superficial infiltrate of mainly lymphocytes with papillary dermal fibrosis (Figure 1E and F). After 1 week, the patient experienced a notable improvement in both the itching sensation and the lesions (Figure 1G). By the end of 8 weeks, the symptoms, particularly the itching (NRS scores decreasing from 7 to 0), had nearly resolved, leaving only residual pigmentation (Figure 1H).