case_images: PMC11208807_01
case_images: Clinical images. (a, b) At the baseline, the patient presented numerous erythematous/desquamative patches and excoriations intermingled with numerous keratotic plugged papules and nodules that were symmetrically distributed over the trunk and at the limbs. (c, d) An almost complete clearance of both eczematous and papule/nodular lesions, with predominant persistence of postinflammatory, was obtained after 12 weeks of treatment with dupilumab.
case_images: CRIDM2024-6265608.001.jpg
case_images: PMC11208807_01_CRIDM2024-6265608.001.jpg
case_images: fig1
case_images: Physical examination showed numerous erythematous-scaling patches with eczematous features and excoriations, intermingled with multiple papules and nodules characterised by a central keratotic plug, that were symmetrically distributed on the trunk and lower extremities (Figures 1(a) and 1(b)). AD-approved dose was initiated. A marked relief from itching (0-10 itch numeric rating scale value from 9 to 2) was reported by the patient after one month of treatment, while a marked clearance of both eczematous and papulonodular lesions was achieved after 12 weeks, with persistence of postinflammatory hyperpigmented macules and rare erythematous macules and patches mainly on the lower legs (Figures 1(c) and 1(d)).
case_images: Histopathological images. (a) A broad epidermal ulceration with extensive scale crust. (b) Vertically oriented degenerated and eosinophilic collagen fibers together with black elastic fibers are extruded through the epidermal breach. ((a) Hematoxylin-eosin stain, original magnification: 20x; (b) Verhoef-Van Gieson stain, original magnification: 100x).
case_images: CRIDM2024-6265608.002.jpg
case_images: PMC11208807_01_CRIDM2024-6265608.002.jpg
case_images: fig2