case_images: PMC10134053_01
case_images: Unilateral retinoblastoma in the left eye. Fundus photo: a right eye, b left eye; ultrasonography: c right eye, d left eye; e coronal T1 magnetic resonance imaging (MRI); f coronal T2 MRI; g axial T1 MRI; and h axial T2 MRI.
case_images: cro530182_f01.jpg
case_images: PMC10134053_01_cro530182_f01.jpg
case_images: F1
case_images: Magnetic resonance imaging confirmed left unilateral retinoblastoma (1.4 x 1.7 x 1.1 cm) with subretinal hemorrhage, no optic nerve involvement, and an unremarkable brain (Fig. 1).
case_images: a Karyotype analysis showed deletion of long arm chromosome 13. b Facial appearance after enucleation with temporary tarsorrhaphy. c Facial appearance after enucleation with ocular prosthesis implantation.
case_images: cro530182_f02.jpg
case_images: PMC10134053_01_cro530182_f02.jpg
case_images: F2
case_images: The eye was examined under general anesthesia and left eye enucleation was performed (Fig. 2).
case_images: Histopathology of ocular and bone marrow tissue. a Ocular tissue with H&E stain x5. b Ocular tissue with H&E stain x40. c Bone marrow tissue with H&E stain x100. d Bone marrow tissue with synaptophysin stain x100. e Bone marrow tissue with CD56 stain x100. The ocular sections reveal retinoblastoma tumor with poorly differentiated cells with extensive areas of anaplasia. The bone marrow sections reveal tiny groups of small round cells that were positive for CD56 and synaptophysin.
case_images: cro530182_f03.jpg
case_images: PMC10134053_01_cro530182_f03.jpg
case_images: F3
case_images: Bone marrow biopsy revealed a few tiny groups of small round cells (5-10% of the total nucleated marrow cells) that were positive for CD56, synaptophysin, and chromogranin A (Fig. 3).
case_images: Digital gangrene of the left hand. a, b Before amputation. c After amputation.
case_images: cro530182_f04.jpg
case_images: PMC10134053_01_cro530182_f04.jpg
case_images: F4
case_images: On day 29 of admission, the left thumb and index finger were amputated, as shown in Figure 4.