case_images: PMC10505434_01
case_images: Summary for Helicobacter pylori screening and treatment in the Saga Prefecture for over 8 years of the study period (2016-2023). Of the total 58,281 patients, 51,265 underwent primary urinary antibody test for H. pylori and 1,733 underwent a secondary stool antigen test. Finally, 1,211 students had two positive tests and were diagnosed with H. pylori infection.
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case_images: fig1
case_images: Figure 1 presents the flowchart for the H. pylori test and treatment program in Saga Prefecture that is being conducted over the 8 years of the study period (2016-2023).
case_images: (A) Esophagogastroduodenoscopy revealed mild antral atrophy (Kimura-Takemoto classification C-2). (B) Atrophy of the fundus and corpus was not observed. None of the findings were suggestive of H. pylori, such as diffuse redness, mucosal swelling, patchy redness, enlarged fold, foveolar-hyperplastic polyp, nodularity, and xanthoma. (C) Mucosal pathological findings in the gastric antrum showed mild atrophy and intestinal metaplasia in part of the epithelium. Chronic inflammatory cell infiltration mainly comprising lymphocytes and plasma cells along with fibrosis was observed in the lamina propria (hematoxylin-eosin stain, x40). (D) Gastrin immunostaining showed no evidence of positive G-cell hyperplasia (x100). (E) Mucosal pathological findings of the gastric corpus showed no atrophy or intestinal metaplasia of the epithelium (hematoxylin-eosin stain, x40).
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case_images: fig2
case_images: Esophagogastroduodenoscopy (EGD) revealed mild antral atrophy (Kimura-Takemoto classification C-2; Figure 2A). Atrophy of the fundus and corpus was not observed (Figure 2B). In the lamina propria, chronic inflammatory cell infiltration mainly comprising lymphocytes and plasma cells was observed, along with fibrosis (Figure 2C). Gastrin immunostaining revealed no evidence of positive G-cell hyperplasia (Figure 2D). Mucosal pathology of the gastric corpus indicated no atrophy or intestinal metaplasia of the epithelium (Figure 2E).
case_images: Result of 16S rRNA gastric microbiota analysis. Neisseria spp., Corynebacterium spp., Haemophilus spp., and Actinomyces spp. were detected at the genus level and have been evaluated as having urease activity.
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case_images: PMC10505434_01_fmed-10-1267180-g003.jpg
case_images: fig3
case_images: Gastric microbiota analysis using 16S rRNA was positive for Neisseria spp., Corynebacterium spp., Haemophilus spp., and Actinomyces spp. at the genus level (Figure 3).