case_images: PMC11182251_01
case_images: Case 1: (A) Intraoperative image of the right eye showing grayish amoeboid epithelial abnormality obstructing the visual axis. (B) Histopathology slide with hematoxylin and eosin (H&E) stain showing increased epithelial thickness with dysplastic features including pleomorphism, prominent nucleoli and loss of polarity, intact underlying basement membrane. Features consistent with corneal intraepithelial neoplasia. (C) Slit-lamp image of the right eye at the final follow-up visit.
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case_images: Biomicroscopy of the cornea revealed a central, grayish, amoeboid epithelial irregularity, measuring approximately 6 mm horizontally and 8 mm vertically ( Figure 1A ). The tumor cells displayed characteristics such as anaplasia, increased mitotic activity, loss of polarity, and pleomorphism ( Figure 1B ). At the last follow-up visit, ten-years post-treatment, the patient's BCVA was 20/200, with no reported recurrence of the lesion ( Figure 1C ).
case_images: PMC11182251_02
case_images: Case 2: (A) Slit-lamp image of the left eye showing central whitish elevated corneal lesion with superficial blood vessels. (B) Histopathology slide with hematoxylin and eosin (H&E) stain showing increased epithelial thickness with dysplastic features including pleomorphism, prominent nucleoli and loss of polarity, intact underlying basement membrane. Features consistent with corneal intraepithelial neoplasia. (C) Slit-lamp image of the left eye at the final follow-up visit.
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case_images: BCVA was 4/200 in the left eye. Biomicroscopy revealed a white, elevated lesion in the cornea measuring approximately 5 mm horizontally and 5 mm vertically ( Figure 2A ). Histopathological examination confirmed the diagnosis of CIN ( Figure 2B ). At the last follow-up appointment, five-years post-treatment, the BCVA was 20/40 there were no reported recurrences ( Figure 2C ).
case_images: PMC11182251_03
case_images: Case 3: (A) Slit-lamp image of the left eye showing inferonasal greyish epithelial lesion with amoeboid appearance involving the visual axis. (B) Anterior segment optical coherence tomography (AS-OCT) of the left eye showing hyperreflective epithelium with abrupt transition between normal and abnormal epithelium (red arrow). (C) Histopathology slide with hematoxylin and eosin (H&E) stain showing increased epithelial thickness with dysplastic features including pleomorphism, prominent nucleoli and loss of polarity. Features consistent with corneal intraepithelial neoplasia. (D) Slit-lamp image of the left eye at the final follow-up visit.
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case_images: Slit lamp examination of the left cornea revealed a grayish, raised epithelial lesion with fimbriated margins, measuring approximately 6 mm horizontally and 2 mm vertically. ( Figure 3A ) Anterior segment optical coherence tomography (AS-OCT) confirmed the presence of hyperreflective epithelial lesion with abrupt transition between normal and abnormal epithelium at the margin of the lesion ( Figure 3B ). Histopathological examination of the excised tissue confirmed severe epithelial dysplasia, consistent with carcinoma in situ ( Figure 3C ). At the last follow-up visit, six-months post-treatment, there were no signs of recurrence and the BCVA was 20/20 in the left eye ( Figure 3D ).