case_images: PMC9445188_01
case_images: (A) Conventional ultrasonography demonstrated an irregular hypoechoic breast lesion without calcification categorized as BI-RADS 4b. (B) Only few vascular spots were seen in the lesion.
case_images: fonc-12-894261-g001.jpg
case_images: PMC9445188_01_fonc-12-894261-g001.jpg
case_images: f1
case_images: Conventional US described a hypoechoic anomalous lump about 13x9 mm, with blurred and angular margins ( Figure 1A ). Color Doppler examination demonstrated 2 vascular spots in the nodule ( Figure 1B ).
case_images: (A) During the arterial phase, the lesion was partial enhanced compared with surrounding tissue. (B) The micro-bubbles rare filled the lesion still the end of arterial phase, and the margin and shape could still be clear after enhancement.
case_images: fonc-12-894261-g002.jpg
case_images: PMC9445188_01_fonc-12-894261-g002.jpg
case_images: f2
case_images: Compared with the surrounding breast tissue, contrast agent began to wash into the lump partially with iso-enhancement in 10 seconds after injection ( Figure 2A ). In 30 seconds, the micro-bubbles rare filled the lesion, and both the margin and shape could still stay clear after enhancement ( Figure 2B ).
case_images: (A) Solid nests of tumor cells with coarsely granular cytoplasm. (hematoxylin-eosin, original magnification x200). (B) Staining was positive for the S-100 protein, as shown by brown granules in the cytoplasm of the tumor cells (original magnification, x200).
case_images: fonc-12-894261-g003.jpg
case_images: PMC9445188_01_fonc-12-894261-g003.jpg
case_images: f3
case_images: With histologic examination of the lump, the lump was composed of sheet-forming polygonal cells filled with eosinophilic cytoplasm granules. ( Figure 3A ) Immunohistochemical staining revealed S-100 protein in cytoplasm was positive ( Figure 3B ).