case_images: PMC10834633_01
case_images: Treatment details and molecular information for HIT-MED cases. In all three cases, patients started treatment analogous to HIT-MED Guidance recommendations for pineoblastoma, which is shown here. A Treatment strategy for 3 HIT-MED cases, B Molecular information for 3 HIT-MED cases, C Explortive tSNE Plot, Reference cases from Liu et al., Acta Neuropathol. 2021 May; 141(5):771-785 (pineoblastoma) and Capper et al., Nature. 2018 Mar 22; 555(7697):469-474 (medulloblastoma), PR partial response, (C)CR (continuous) complete remission, i.v. intravenous, i. ventr. intraventricularly, HDCT high-dose chemotherapy, ASCT autologous stem-cell transplantation
case_images: 11060_2023_4547_Fig1_HTML.jpg
case_images: PMC10834633_01_11060_2023_4547_Fig1_HTML.jpg
case_images: Fig1
case_images: The tumor's methylation profile also matched with PB, FOXR2 (Fig. 1B, C). The patient presented with a large tumor reaching from the pineal region supratentorielly into the posterior part of the third ventricle and infratentorielly into the tectal region and the quadrigeminal cistern, compressing the brainstem and cerebellum (Fig. 1D) with radiologically unclear origin.
case_images: Clinical courses and Kaplan Meier Survival Estimation. A Overview of individual cases` clinical course incl. treatment and outcomes, B Kaplan-Meier Plot (treatment-dependent) for n = 13 cases (above) with available treatment and follow-up data (n = 2 excluded due to death from early postoperative complications) and for n = 11 cases (below) with adjuvant treatment (n = 2 excluded due to surgery only), C Kaplan-Meier Plot (all cases with available treatment and follow-up data), D Treatment response for HIT-MED cases. *centrally reviewed. PD progressive disease, SD stable disease, PR partial response, CR complete remission, HDCT high-dose chemotherapy, RT radiotherapy
case_images: 11060_2023_4547_Fig2_HTML.jpg
case_images: PMC10834633_01_11060_2023_4547_Fig2_HTML.jpg
case_images: Fig2
case_images: Follow-up MRI showed a lesion in the right cerebellar hemisphere (supplemental Fig. 2.5). Fig. 2D. Further, 4 more patients from the literature received HDCT with ASCT after induction chemotherapy resulting in a series of 7 cases. For these cases, 2-year progression-free survival (PFS) was 65.2 +- 12.7% (Fig. 2C). All 4 patients who received high-dose chemotherapy combined with RT (focal RT: 2, CSI: 2) had no recurrence and were alive at last follow-up (Fig. 2B).