case_images: PMC10535097_01
case_images: Brain MRI series of the patient. The following findings are described in the figure panel: (A) No abnormal signal is found on the T1 sequence; (B) Brain MRI revealed T2 hyperintense lesions in the cerebral cortex and bilateral hippocampus; (C) A corresponding fluid-attenuated inversion recovery (FLAIR) sequence shows extensive hyperintense signals in the cerebral cortex and bilateral hippocampus.
case_images: fimmu-14-1258048-g001.jpg
case_images: PMC10535097_01_fimmu-14-1258048-g001.jpg
case_images: f1
case_images: A brain MRI showed diffuse and extensive T2/FLAIR hypersignal in the cerebral cortex and bilateral hippocampus ( Figure 1 ).
case_images: The immunoreactivity of patient's GFAP-IgG via cell-based assay (CBA) in CSF and serum. (A) HEK293 cells stably express green fluorescent proteintagged GFAPa. (B) The red fluorescence represents the GFAP antibody in the sample; (C) Colocalization of the patient's GFAP IgG, GFAPa is yellow in the merged images (A, B); (D-F) Negative serum test results of anti-GFAP antibody.
case_images: fimmu-14-1258048-g002.jpg
case_images: PMC10535097_01_fimmu-14-1258048-g002.jpg
case_images: f2
case_images: However, the patient obtained positive CSF test results for anti-glial fibrillary acidic protein (GFAP) antibodies, with titers of 1:1+ ( Figure 2 ), confirmed with cell-based assay (CBA).
case_images: Characteristic brain MR images of autoimmune GFAP astrocytopathy. (A) Brain MRI showed the disappearance of T2/flair high signal in the cerebral cortex and bilateral hippocampus compared with previous brain MRI. (B) The sagittal section showed linear perivascular radial gadolinium enhancement in the white matter perpendicular to the ventricle. (C) Brain MR axial position suggests vascular enhancement perpendicular to the lateral ventricle.
case_images: fimmu-14-1258048-g003.jpg
case_images: PMC10535097_01_fimmu-14-1258048-g003.jpg
case_images: f3
case_images: A contrast-enhanced MRI revealed linear perivascular radial gadolinium enhancement in the white matter perpendicular to the ventricle ( Figure 3 ).
case_images: Timeline of clinical course. The clinical, radiological characteristics and treatment of the patient.
case_images: fimmu-14-1258048-g004.jpg
case_images: PMC10535097_01_fimmu-14-1258048-g004.jpg
case_images: f4
case_images: The clinical and radiological characteristics and treatment were summarized in  Figure 4 .