case_images: PMC6769215_01
case_images: Skin lesions in trunk and hands.. The patient presented multiple non-homogeneous, hypochromic, well-defined macules associated with post-inflammatory hypopigmentation in the skin of the upper back (panel A). In the interdigital region of both hands, the patient presented white-yellowish, confluent, smooth-surface papules with irregular borders. Similar lesions were found in the dorsum of the hand (panel B).
case_images: 10.1177_1179551419878687-fig1.jpg
case_images: PMC6769215_01_10.1177_1179551419878687-fig1.jpg
case_images: fig1-1179551419878687
case_images: There was generalized mucocutaneous jaundice with multiple zones of post-inflammatory hypopigmentation (Figures 1 to 3) and yellowish, well-defined papules in the perioral area (Figure 2) and interdigital folds (Figure 1).
case_images: Lesions in the skin of the face.. The patient presented multiple yellowish papules with smooth, shiny surface and regular, well-defined borders in the perioral region (panel A) and chin (panel B).
case_images: 10.1177_1179551419878687-fig2.jpg
case_images: PMC6769215_01_10.1177_1179551419878687-fig2.jpg
case_images: fig2-1179551419878687
case_images: There was generalized mucocutaneous jaundice with multiple zones of post-inflammatory hypopigmentation (Figures 1 to 3) and yellowish, well-defined papules in the perioral area (Figure 2) and interdigital folds (Figure 1).
case_images: Lesions in the skin of the limbs.. The patient presented multiple non-homogeneous, hypochromic macules with associated mild excoriations in the legs and knees (panel A) and the forearm (panel B).
case_images: 10.1177_1179551419878687-fig3.jpg
case_images: PMC6769215_01_10.1177_1179551419878687-fig3.jpg
case_images: fig3-1179551419878687
case_images: There was generalized mucocutaneous jaundice with multiple zones of post-inflammatory hypopigmentation (Figures 1 to 3) and yellowish, well-defined papules in the perioral area (Figure 2) and interdigital folds (Figure 1).
case_images: Lesions in the skin of the hands, after 4 months of treatment: (a) Dorsum of the hands. (b) Palms of the hands.. There was a noticeable reduction in the number and severity of papules and in the associated hypopigmentation.
case_images: 10.1177_1179551419878687-fig4.jpg
case_images: PMC6769215_01_10.1177_1179551419878687-fig4.jpg
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case_images: Over the first few weeks of management, the patient exhibited progressive improvement of pruritus, jaundice, and skin lesions (Figure 4), in addition to a decline in plasma markers of cholestasis (Table 1).
case_images: Results from non-denaturing lipoprotein gel electrophoresis in 5% agarose.. We ran in parallel and under the same conditions, plasma from the patient and from 3 healthy controls.
case_images: 10.1177_1179551419878687-fig5.jpg
case_images: PMC6769215_01_10.1177_1179551419878687-fig5.jpg
case_images: fig5-1179551419878687
case_images: Bands from controls exhibited a typical migration pattern with beta migration for LDL and alpha migration for HDL, whereas the patient's sample showed essentially a pattern of zero to gamma mobility, consistent with the presence of LpX (Figure 5).