case_images: PMC11075613_01
case_images: Pituitary magnetic resonance images of the patient before (a) and (b) and after chemo-radiotherapy (c) and (d). (a) and (b) These show enlarged sella turcica forming a heterogeneous intra- and suprasellar mass measuring 20 x 17 mm with a nodular thickening of the pituitary stalk. This mass compressed the optic chiasm. (c) and (d) Magnetic resonance imaging 6 months after the end of oncologic treatment shows the disappearance of pituitary infiltration.
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case_images: There was also an enhanced nodular thickening of the pituitary stalk (Figure 1). The diagnosis of an invasive nasopharyngeal mass with diffuse perineural, endocranial, and meningeal infiltration, and extension to the sella turcica was suspected. TPF: cisplatin 60 mg/m2, 5-fluorouracil 600 mg/m2, and docetaxel 60 mg/m2 for two cycles, followed by radiotherapy with a total delivered dose of 70 Gy in 35 fractions. The outcome was marked by the disappearance of pituitary infiltration and the absence of nasopharyngeal tumor recurrence on the MRI performed 6 months after the end of the oncologic treatment (Figure 1).
case_images: (a) Hematoxylin and eosin x 40: Undifferentiated carcinomatous proliferation organized in clusters within a lymphoid stroma. (b) Immunohistochemistry x 40: The tumor cells express cytokeratin.
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case_images: Histopathological examination confirmed the diagnosis of undifferentiated NPC (Figure 2).