case_images: PMC3792542_01
case_images: Granules of stainable iron (haemosiderin) within cytoplasm of epithelium of minor glands of the mucosa of the lower lip. Perls' technique with nuclear fast red counterstain, original magnification 1,000x.
case_images: CDI2013-642643.001.jpg
case_images: PMC3792542_01_CDI2013-642643.001.jpg
case_images: fig1
case_images: The diagnosis of NH was confirmed at 12 days of age by microscopy of a lower lip mucosa biopsy specimen, which found haemosiderin granules within submucosal acinar gland cells (Figure 1).
case_images: Hepatectomy specimen, postnatal age 30 days. Nodularity is apparent. The relatively stroma-poor nodules consisted of hepatocellular parenchyma, sometimes cholestatic. The intervening regions that exhibit more compact connective-tissue elements were sites of hepatocellular loss and stromal collapse, with neocholangiolar transformation of remaining parenchyma. Reticulin, original magnification 40x.
case_images: CDI2013-642643.002.jpg
case_images: PMC3792542_01_CDI2013-642643.002.jpg
case_images: fig2
case_images: Examination of the explanted liver found postnecrotic cirrhosis with canalicular and hepatocellular cholestasis (Figure 2).