case_images: PMC10895312_01
case_images: Contrast-enhanced CT of the thorax illustrating heterogeneously enhancing asymmetric wall thickening in mid-esophagus with extension (A) and lymphadenopathy (B).
case_images: cureus-0016-00000053027-i01.jpg
case_images: PMC10895312_01_cureus-0016-00000053027-i01.jpg
case_images: FIG1
case_images: Multiple hypo-enhancing round-to-oval lesions were observed in both hepatic lobes, with the largest lesion noted in the right lobe (2.5x2.3cm) (Figure 1).
case_images: Upper gastrointestinal endoscopic examination illustrating a large circumferential ulceroproliferative friable mass in the esophagus (A and B).
case_images: cureus-0016-00000053027-i02.jpg
case_images: PMC10895312_01_cureus-0016-00000053027-i02.jpg
case_images: FIG2
case_images: Moreover, there was the presence of two umbilicated lesions in the esophagus, at 24 and 34cm (Figure 2).
case_images: Histopathological examination illustrating an infiltrating malignant epithelial tumor consisting of small cells with scant cytoplasm and pleomorphic, hyperchromatic nuclei (10x H&E stain, A). The malignant nuclei showed prominent nuclear molding, and extensive necrosis suggestive of a poorly differentiated, small cell type E-NEC (40x H&E stain, B).
case_images: cureus-0016-00000053027-i03.jpg
case_images: PMC10895312_01_cureus-0016-00000053027-i03.jpg
case_images: FIG3
case_images: These findings led to the diagnosis of a poorly differentiated, small cell type E-NEC (Figure 3).