case_images: PMC11152169_01
case_images: Native and tissue-factor + tissue plasminogen activator thromboelastography (TEG) tracing in a dog with persistent epistaxis. The top tracing is the tissue factor and tissue plasminogen activator TEG tracing, and the bottom tracing is the native tracing. A clot was not able to be formed in the presence of tissue plasminogen activator. Angle, Alpha angle; CLT, Clot lysis time; G, Shear elastic modulus; K, Clot formation time; LY30, Clot Lysis at 30 min; LY60, Clot lysis at 60 min; MA, Maximum amplitude; R, Reaction time; SD, Standard deviation; TEG, Thromboelastography; TF, Tissue factor; tPA, Tissue plasminogen activator.
case_images: fvets-11-1375507-g001.jpg
case_images: PMC11152169_01_fvets-11-1375507-g001.jpg
case_images: fig1
case_images: Native thromboelastography (TEG) (using no activators) demonstrated a prolonged initiation to clot formation, in addition to delayed clot kinetics and an extremely weak clot (Figure 1). A clot was not able to be formed in the tissue-factor + tPA TEG tracing (Figure 1).
case_images: Whole blood impedance platelet aggregometry in a dog with persistent epistaxis. Two platelet agonists were evaluated: adenosine diphosphate (ADP) and arachidonic acid (ASPI). RI, Reference interval. ADP RI (175-294), ASPI RI (131-325).
case_images: fvets-11-1375507-g002.jpg
case_images: PMC11152169_01_fvets-11-1375507-g002.jpg
case_images: fig2
case_images: Platelet aggregometry was performed with a multiple electrode aggregometer (Multiplate 5.0 Analyzer, DiaPharma Group Inc., West Chester, Ohio) using whole blood impedance aggregometry and showed decreased aggregation compared with institution reference ranges in the presence of two platelet agonists [adenosine diphosphate (ADP) and arachidonic acid (ASPI)] (Figure 2).