case_images: PMC11586800_01
case_images: Clinical feature. Ecchymosis, blisters and blood blisters on the extremities. A: Ecchymosis and blood blisters on the swollen right upper extremity. B: Blisters and blood blisters on the left wrist. C: Bean-sized blood blisters on the right forearm. D: Ecchymosis on the left upper extremity.
case_images: 94294-g001.jpg
case_images: PMC11586800_01_94294-g001.jpg
case_images: F1
case_images: We also noted ecchymosis on both upper limbs accompanied by severe swelling of the left hand and forearm as well as erosion of the oral mucosa, which was covered with exudates (Figure 1).
case_images: Hematoxylin and eosin staining. Subepidermal blister (red arrow), which contains eosinophils (yellow arrow) and infiltration of eosinophils around small vessels in the dermis. A: Hematoxylin and eosin (HE) x 10; B: HE x 40; C: HE x 100.
case_images: 94294-g002.jpg
case_images: PMC11586800_01_94294-g002.jpg
case_images: F2
case_images: Histopathologic testing indicated a subepidermal blister containing eosinophils and infiltration of eosinophils around small vessels in the dermis (Figure 2).
case_images: Direct immunofluorescence. Linear typical deposition of complement C3 along the dermo-epidermal junction.
case_images: 94294-g003.jpg
case_images: PMC11586800_01_94294-g003.jpg
case_images: F3
case_images: Direct immunofluorescence (DIF) revealed linear typical deposition of complement C3 along the dermo-epidermal junction (Figure 3).