case_images: PMC10807503_01
case_images: (A) Chest computed tomography before introduction of sotorasib reveals a mass shadow in the right upper lobe. (B) On day 80 after the start of sotorasib, the mass shadow had shrunk slightly. (C) Chest computed tomography before treatment with sotorasib shows no obvious abnormal shadows in the background lungs. (D) On day 80 after the administration of sotorasib, extensive ground glass opacities found in both lung lobes.
case_images: RCR2-12-e01284-g003.jpg
case_images: PMC10807503_01_RCR2-12-e01284-g003.jpg
case_images: rcr21284-fig-0001
case_images: Although sotorasib led to stable disease, on the 80th day after starting sotorasib, cough and dyspnea appeared, and chest computed tomography revealed ground glass opacities in all lung lobes (Figure 1).
case_images: (A) Chest radiography before the introduction of sotorasib showing no ground glass opacities in both lung fields. (B) Chest radiography on day 80 after the start of sotorasib reveals ground glass opacities in both lung fields with decreased lung volume. (C) After prednisolone treatment, ground glass opacities in both lung fields disappear and lung volume improves, but the mass shadow in the right upper lung field increased.
case_images: RCR2-12-e01284-g001.jpg
case_images: PMC10807503_01_RCR2-12-e01284-g001.jpg
case_images: rcr21284-fig-0002
case_images: Prednisolone 30 mg/day (0.5 mg/kg/day) was introduced, and the lung disorder quickly resolved (Figure 2).
case_images: Clinical course of the present case.
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case_images: PMC10807503_01_RCR2-12-e01284-g002.jpg
case_images: rcr21284-fig-0003
case_images: She has not relapsed for several months following treatment (Figure 3).