case_images: PMC5660109_01
case_images: Initial presentation of the patient: (A) the right nipple lesion. Initial presentation of the patient: (B) macroscopic right nipple lesion, erosion, and redness of the nipple were noted.
case_images: fsurg-04-00051-g001.jpg
case_images: PMC5660109_01_fsurg-04-00051-g001.jpg
case_images: F1
case_images: The examination revealed an eczematous aspect of the right nipple suggesting Paget's disease (Figures 1A,B).
case_images: Mammography showed a dense ovoid opacity of 14 mm with irregular suspicious micro calcifications.
case_images: fsurg-04-00051-g002.jpg
case_images: PMC5660109_01_fsurg-04-00051-g002.jpg
case_images: F2
case_images: Mammography showed a dense ovoid opacity of 14 mm with irregular suspicious micro calcifications (Figure 2).
case_images: Ultrasound right nipple: suspect galactophoric dilatation of the right supero-external quadrant.
case_images: fsurg-04-00051-g003.jpg
case_images: PMC5660109_01_fsurg-04-00051-g003.jpg
case_images: F3
case_images: A suspect galactophoric dilatation of the right supero-external quadrant was seen by ultrasound (Figure 3).
case_images: (A,B) Images coupe de biopsie. Biopsy concluded to a ductal multicentric carcinoma in situ, nuclear grade 2-3, HER2 (+), ER, and PRG (-), classification as B5a. Microscopic examination of the specimen using H&E staining. (A) The epidermis of the nipple infiltrated by large Paget's cells with pale abundant cytoplasm (magnification, x100). (B) Single groups of Paget's cells with vesicular nuclei and prominent nucleoli (magnification, x400).
case_images: fsurg-04-00051-g004.jpg
case_images: PMC5660109_01_fsurg-04-00051-g004.jpg
case_images: F4
case_images: B5a (Figures 4A,B). Breast magnetic resonance imaging (MRI) revealed several multicentric tumoral lesions of the right breast with extension to the nipple-areola complex (Figure 5).
case_images: Breast magnetic resonance imaging revealed several multicentric tumoral lesions of the right breast with extension to the nipple-areola complex.
case_images: fsurg-04-00051-g005.jpg
case_images: PMC5660109_01_fsurg-04-00051-g005.jpg
case_images: F5
case_images: B5a (Figures 4A,B). Breast magnetic resonance imaging (MRI) revealed several multicentric tumoral lesions of the right breast with extension to the nipple-areola complex (Figure 5).