case_images: PMC2716486_01
case_images: Esophagoscopy showing several flat and black pigmented mucosal lesions in the distal esophagus and esophagogastric junction (arrows).
case_images: GRP2009-285753.001.jpg
case_images: PMC2716486_01_GRP2009-285753.001.jpg
case_images: fig1
case_images: Esophagoscopy revealed several flat and black pigmented mucosal lesions with a short shallow mucosal break in the distal esophagus and esophagogastric junction (Figures 1  and 2).
case_images: Esophagoscopy showing flat and black pigmented mucosal lesions with reflux esophagitis in close up of esophagogastric junction.
case_images: GRP2009-285753.002.jpg
case_images: PMC2716486_01_GRP2009-285753.002.jpg
case_images: fig2
case_images: Esophagoscopy revealed several flat and black pigmented mucosal lesions with a short shallow mucosal break in the distal esophagus and esophagogastric junction (Figures 1  and 2).
case_images: Histologically the tumor mainly consisted of poorly cohesive neoplastic cells with hyperchromic muclei and cytosolic melanin granules which predominantly proliferated in the mucosa (Hematoxylin and eosin stain, x400).
case_images: GRP2009-285753.003.jpg
case_images: PMC2716486_01_GRP2009-285753.003.jpg
case_images: fig3
case_images: Microscopic examination of biopsy specimens showed proliferation of poorly cohesive neoplastic cells with hyperchromic nuclei and cytosolic melanin granules which predominantly proliferated in the mucosa (Figure 3, H&E stain, x400).
case_images: Immunohistochemical stain. The cells sporadically showed immunoreactivity for S-100 protein (x400, a) and HMB-45 antibody (x400, b).
case_images: GRP2009-285753.004.jpg
case_images: PMC2716486_01_GRP2009-285753.004.jpg
case_images: fig4
case_images: The cells sporadically showed immunoreactivity for S-100 protein and HMB-45 antibody (Figure 4, x400).