case_images: PMC11774574_01
case_images: PMC11774574_02
case_images: Severely thickened skin with shiny plates of hyperkeratotic scales.
case_images: CRIDM2025-7982066.001.jpg
case_images: PMC11774574_02_CRIDM2025-7982066.001.jpg
case_images: fig1
case_images: These features were more pronounced on the scalp, trunk, and abdominal areas, as demonstrated in Figures 1 and 2. The lips were everted, exposing the mucosal lining (eclabium), as illustrated in Figure 1. The upper limbs were asymmetrical, with the right hand being smaller, contracted at the elbow, and flexed with contractures (Figures 1 and 4).
case_images: Severe ectropion and eclabium exposing the conjunctivae, cornea, and oral mucosa, respectively.
case_images: CRIDM2025-7982066.002.jpg
case_images: PMC11774574_02_CRIDM2025-7982066.002.jpg
case_images: fig2
case_images: These features were more pronounced on the scalp, trunk, and abdominal areas, as demonstrated in Figures 1 and 2. The scalp was covered with thick, black, shiny hair, and a diamond-shaped, erythematous hyperkeratotic fissure traversed through a membranous layer, as shown in Figure 2.
case_images: Severe ectropion and hypoplastic ears in harlequin ichthyosis.
case_images: CRIDM2025-7982066.003.jpg
case_images: PMC11774574_02_CRIDM2025-7982066.003.jpg
case_images: fig3
case_images: The retro-auricular folds and pinnae were rudimentary, small, and covered with a scaly membrane (Figure 3).
case_images: Right upper limb encased with thick hyperkeratotic skin with hypoplastic digits.
case_images: CRIDM2025-7982066.004.jpg
case_images: PMC11774574_02_CRIDM2025-7982066.004.jpg
case_images: fig4
case_images: The upper limbs were asymmetrical, with the right hand being smaller, contracted at the elbow, and flexed with contractures (Figures 1 and 4).
case_images: Genitalia in harlequin ichthyosis.
case_images: CRIDM2025-7982066.005.jpg
case_images: PMC11774574_02_CRIDM2025-7982066.005.jpg
case_images: fig5
case_images: The clitoris was not visible, and no abnormal discharge or bleeding was noted (Figure 5).