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case_images: PMC10853403_02
case_images: Renal calculi throughout the years. Microscopic image showcasing the assortment of renal calculi collected over several years. The top 2 containers are prior to 2021. The bottom left container is from 2021, and the bottom right corner is from 2022. The image highlights a multitude of supernumerary renal calculi, elucidating their recurrent formation. The correlation between these calculi and tick-borne infections is explored in this case report, presenting a potential link worthy of further investigation.
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case_images: The patient passed 57 stones in 2021 and 49 stones in 2022, as shown in  Figure 1 .
case_images: Line graph showing an increase in Vitamin D levels following supplementation. Graphical representation illustrating the patient's dynamic Vitamin D levels over time. The patient initially had a level of 20ng/mL (normal range between 20 to 40ng/mL) on October 28th 2022, as indicated by the green arrow. The graph demonstrates a significant rise in Vitamin D levels following supplementation. From an initial deficient state, the patient's Vitamin D levels increased to 33 ng/mL, as seen by the orange arrow, showcasing the impact of Vitamin D supplementation. This observation is pertinent to the investigation into the relationship between supernumerary recurrent renal calculi formation and potential associations with tick-borne infections, offering insights into the potential role of Vitamin D in this context.
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case_images: Laboratory evaluation revealed deficient Vitamin D level of 20 ng/mL (nl range 30-100 ng/mL), and an elevated parathyroid hormone level of 92.3 pg/mL (nl range 10.8-79.4 pg/mL),  Figures 2 ,  3 .
case_images: Line graph showing a decrease in PTH following Vitamin D supplementation. Bar graph showing the impact of Vitamin D supplementation on Parathyroid Hormone (PTH) levels in our patient. The graph displays a noticeable decrease from an initial PTH level of 92 pg/mL, as seen by the grey arrow, to 83 pg/mL, as shown by the black arrow, following Vitamin D supplementation. This decline in PTH levels suggests a regulatory effect of Vitamin D on parathyroid function; Vitamin D plays a pivotal role in calcium homeostasis. When Vitamin D levels are low, there is a resultant rise in PTH secretion from the parathyroid glands, aiming to increase calcium absorption. Consequently, when Vitamin D levels are high, PTH levels decrease. The normal range of PTH levels range from 10 to 80 pg/mL, as shown by the green dashed and green solid lines, respectively.
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case_images: Laboratory evaluation revealed deficient Vitamin D level of 20 ng/mL (nl range 30-100 ng/mL), and an elevated parathyroid hormone level of 92.3 pg/mL (nl range 10.8-79.4 pg/mL),  Figures 2 ,  3 .
case_images: Axial CT scan of the Abdomen and Pelvis revealing numerous renal calculi. Axial CT scan images of the Abdomen and Pelvis depicting the presence of numerous renal calculi primarily localized in the right kidney, as seen by the red arrow. Additionally, visualization reveals the presence of renal calculi in the left kidney, albeit to a lesser extent, indicated by the blue arrow.
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case_images: CT of the abdomen and pelvis revealed extensive nephrolithiasis in the right kidney, with sparse calculi in the left kidney, as seen in  Figure 4 .