case_images: PMC6304869_01
case_images: Levels of neutrophil CD64 elevated with dissociation of a CRP change (case 1). The cutoff value for the levels of neutrophil CD64 was 2000 molecules/cell.
case_images: CRIRH2018-2856546.001.jpg
case_images: PMC6304869_01_CRIRH2018-2856546.001.jpg
case_images: fig1
case_images: In April 2010, intravenous administration of vancomycin or teicoplanin (TEIC) improved the aforementioned symptoms (Figure 1).
case_images: Computed tomography scan images of case 1. Particulate lesions diffusely observed in both lung fields (a) were diminished after antituberculosis therapy (b); cystic lesion with the same absorption range as abscess observed in paraspinal muscle (c) was also diminished after antituberculosis therapy (d).
case_images: CRIRH2018-2856546.002.jpg
case_images: PMC6304869_01_CRIRH2018-2856546.002.jpg
case_images: fig2
case_images: Whole-body computed tomography (CT) revealed diffuse small granular shadows on both lungs and fluid accumulations (abscess) around the lumbar vertebrae Figures 2 and 2. September 2010, after treatment for TB, the levels of neutrophil CD64 decreased below the cutoff value (<2000 molecules/cell) and abnormal findings on the CT scan disappeared Figures 2 and 2. Sustained high levels of neutrophil CD64 were considered to be due to reactivation of LTBI.
case_images: PMC6304869_02
case_images: Levels of neutrophil CD64 increased even after antibiotic therapy (case 2).
case_images: CRIRH2018-2856546.003.jpg
case_images: PMC6304869_02_CRIRH2018-2856546.003.jpg
case_images: fig3
case_images: In May 2011, treatment with antibiotics was associated with slight fever, elevated serum CRP, and continuous elevation of neutrophil CD64 (up to 18,831 molecules/cell) (Figure 3).
case_images: (a) Chest CT scan image at the time of admission. Diffuse particulate shadows are shown in the whole-lung field at random; (b) noncaseating epithelioid granuloma was observed in bronchial and alveolar specimens obtained through bronchoscopy (hematoxylin and eosin (H & E) stain; magnification x400); (c) a cellulitis-like lesion on the patient's right lower limb; (d) biopsy specimens from cellulitis also revealed erythema induratum of Bazin (H & E stain; magnification x400) (case 2).
case_images: CRIRH2018-2856546.004.jpg
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case_images: fig4
case_images: ADA was discontinued and further examination revealed diffuse reticulonodular shadows in the lung fields through chest X-ray and CT scan, suggesting the development of miliary TB (Figure 4). Noncaseating epithelioid granuloma was observed in bronchial and alveolar specimens obtained through bronchoscopy (Figure 4). Biopsy specimens from a cellulitis-like lesion on the patient's right lower limb (Figure 4) also revealed erythema induratum of Bazin (Figure 4).
case_images: PMC6304869_03
case_images: High levels of neutrophil CD64 were maintained since admission to the hospital (case 3).
case_images: CRIRH2018-2856546.005.jpg
case_images: PMC6304869_03_CRIRH2018-2856546.005.jpg
case_images: fig5
case_images: The levels of serum CRP were approximately 1 mg/dl, and the levels of neutrophil CD64 were highly elevated (up to 11,387 molecules/cell) (Figure 5).
case_images: (a, b) Fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging of the brain revealed pia-subarachnoid enhancement (case 3).
case_images: CRIRH2018-2856546.006.jpg
case_images: PMC6304869_03_CRIRH2018-2856546.006.jpg
case_images: fig6
case_images: A pia-subarachnoid enhancement was found on the fluid-attenuated inversion recovery (FLAIR) sequence, which was compatible with meningitis (Figure 6).