case_images: PMC11233442_01
case_images: (A) Serum levels of tacrolimus [ng/ml] over 24 h. Blue line: Serum levels of extended-release tacrolimus (ER-Tac) once daily (SID, 12 mg); red line: serum levels of extended-release tacrolimus (ER-Tac) twice daily (BID, 2 x 5 mg). The AUC (area under the concentration-time curve) was calculated using PRISM by GraphPad. The time points used to calculate the AUC are marked on the x-axis. (B) Estimated glomerular filtration rate (eGFR) [ml/min/1.73m2] according to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) (blue line) and extended-release tacrolimus (ER-Tac) trough levels over time (red line). The black dashed line marks the switch from ER-Tac once daily (SID) to ER-Tac twice daily (BID).
case_images: fmed-11-1336035-g001.jpg
case_images: PMC11233442_01_fmed-11-1336035-g001.jpg
case_images: fig1
case_images: According to the relatively high dose, the area under the concentration-time curve (AUC) showed exceedingly high blood levels of ER-Tac (Figure 1A). After switching to ER-Tac twice daily (BID), the AUC for oral tacrolimus (Figure 1A) and the transplant function fortunately improved despite higher tacrolimus trough levels and a lower total dose administered (Figure 1B).