case_images: PMC6721109_01
case_images: Plasmablastic lymphoma: (a) large pleomorphic neoplastic cells with prominent nucleoli and abundant cytoplasm, H&E stain (40x); (b) weak positive CD45 immunostain (20x); (c) positive CD79a immunostain (20x); (d) negative CD20 immunostain (20x).
case_images: CRICC2019-4642925.001.jpg
case_images: PMC6721109_01_CRICC2019-4642925.001.jpg
case_images: fig1
case_images: The lymph node pathology showed sheets of large, highly pleomorphic neoplastic cells with abundant cytoplasm, irregular nuclei, and variably prominent nucleoli (Figure 1). Immunohistochemical stains showed a plasmacytic phenotype with positive expression of CD79A, CD45 (weak), CD30, MUM1, and CD138 while negative staining for CD20 and PAX5 (Figure 1).
case_images: Lactic acid levels (in mmol/L) of patient starting at admission until resolution. Red bar indicates administration of EPOCH chemotherapy that finished on hospital day 11.
case_images: CRICC2019-4642925.002.jpg
case_images: PMC6721109_01_CRICC2019-4642925.002.jpg
case_images: fig2
case_images: HD5 (Figure 2). Her lactic acidosis was considered to be secondary to her underlying lymphoma since she never had an infectious source, hypovolemic state, or low/high cardiac-output state. Figure 2. Following the administration of EPOCH, the patient was transferred out of the ICU.