case_images: PMC11748124_01
case_images: (A, B) Ultra-widefield fundus photographs show salt-and-pepper retinal dystrophy and no apparent bone spicule pigmentation. (C, D) Optical coherence tomography reveals generalized loss of the ellipsoid zone outside of the foveal area. (E, F) Ultra-widefield fundus autofluorescence reveals nearly absent autofluorescence signal with abnormal foveal hyperautofluorescence and patchy hypoautofluorescent lesions. (G, H) Optical coherence tomography reveals diffuse loss of the ellipsoid zone with a small residual ellipsoid zone at the fovea center, disorganization of layer stratification, and thin epiretinal membrane. (I) Electroretinogram shows extinguished rod and cone responses.
case_images: MGG3-13-e70060-g001.jpg
case_images: PMC11748124_01_MGG3-13-e70060-g001.jpg
case_images: mgg370060-fig-0001
case_images: Ultra-widefield fundus photographs revealed salt-and-pepper retinal dystrophy with substantial RPE mottling and fine pigment clumping (Figure 1A,B). Optical coherence tomography (OCT) showed generalized disruption of foveal microstructures, with a relatively preserved central ellipsoid zone in both eyes (Figure 1C,D). Fundus autofluorescence demonstrated diffuse extinguished autofluorescence signal with abnormal foveal hyperautofluorescence and patchy hypoautofluorescent lesions in both eyes (Figure 1E,F). OCT revealed extensive disruption of foveal microstructures, with a small area of preserved ellipsoid zone subfoveally in both eyes (Figure 1G,H). The electroretinogram revealed extinguished rod and cone responses in both eyes (Figure 1I).