case_images: PMC10637573_01
case_images: Abnormal EEG. (A) Pre-treatment EEG shows More extensive slow waves. (B) Post-treatment EEG shows slow waves in the left temporal region (limited reduction than pre-treatment slow waves).
case_images: fimmu-14-1274420-g001.jpg
case_images: PMC10637573_01_fimmu-14-1274420-g001.jpg
case_images: f1
case_images: The EEG indicated a dominant rhythm without prominence, increased slow wave activity during wakefulness, and occasional paroxysmal multi-spike slow waves during sleep ( Figure 1A ). The abnormal behaviors notably improved after treatment, and EEG results improved ( Figure 1B ).
case_images: Positive serum anti-mGluR5 IgG expression (double immunofluorescence cell staining; original magnification 400x). (A) Serum tested. mGluR5 high expression plasmid transfected cells show green fluorescence (1). Anti-mGluR5 antibodies show red fluorescence (2). mGluR5 antigen antibody fluorescence overlap (3). (B) Negative control. GFP-transfected cells (4). Negative mGluR5 antibodies immunofluorescence (5). Fluorescence overlap (6).
case_images: fimmu-14-1274420-g002.jpg
case_images: PMC10637573_01_fimmu-14-1274420-g002.jpg
case_images: f2
case_images: Double immunofluorescence cell staining revealed elevated anti-mGluR5 antibody levels in the serum (1:1000) ( Figure 2 ).