case_images: PMC11735052_01
case_images: Head and neck computed tomography images. (A) CT scan revealed a solid mass of the right submandibular gland, infiltrating the right parotid gland and lower jaw, and bilateral cervical lymphadenopathy at baseline. (B) CT reexamination showed that both submandibular solid mass and cervical bilateral lymphadenopathy were significantly reduced after chemotherapy. (C) CT scan showed additional reduction of submandibular mass and cervical bilateral lymphadenopathy after 3 months of neratinib treatment.
case_images: CNR2-8-e70065-g002.jpg
case_images: PMC11735052_01_CNR2-8-e70065-g002.jpg
case_images: cnr270065-fig-0001
case_images: A total-body computed tomography (CT) scan revealed a solid mass in the right submandibular gland, infiltrating the right parotid gland and lower jaw, along with bilateral cervical lymphadenopathy and lung metastases (Figure 1A; Figure 2A,B). Therefore, from March 2019 to July 2019, the patient received first line chemotherapy with cisplatin 60 mg/sqm and doxorubicin 50 mg/sqm, for 4 cycles, resulting in a partial response across all disease sites (Figure 1B; Figure 2C,D). A CT scan at that time showed stable disease (Figure 1C; Figure 2E,F), and neratinib was resumed.
case_images: Chest computed tomography images. (A, B) CT scan revealed multiple lung metastases at baseline. (C, D) CT reexamination showed size reduction of lung metastases after chemotherapy treatment. (E, F) CT reexamination showed substantial stability of lung metastases after 3 months of neratinib treatment.
case_images: CNR2-8-e70065-g001.jpg
case_images: PMC11735052_01_CNR2-8-e70065-g001.jpg
case_images: cnr270065-fig-0002
case_images: A total-body computed tomography (CT) scan revealed a solid mass in the right submandibular gland, infiltrating the right parotid gland and lower jaw, along with bilateral cervical lymphadenopathy and lung metastases (Figure 1A; Figure 2A,B). Therefore, from March 2019 to July 2019, the patient received first line chemotherapy with cisplatin 60 mg/sqm and doxorubicin 50 mg/sqm, for 4 cycles, resulting in a partial response across all disease sites (Figure 1B; Figure 2C,D). A CT scan at that time showed stable disease (Figure 1C; Figure 2E,F), and neratinib was resumed.