case_images: PMC5774134_01
case_images: PMC5774134_02
case_images: Overall graphical summary of CNAs in patients with hyperdiploid MM and CTH affected chromosome 18
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case_images: PMC5774134_02_13039_2018_357_Fig1_HTML.jpg
case_images: Fig1
case_images: CNAs were observed as deletions in 1q, 8p and 16p, while areas of gain of genetic material were found in 1q and 16q. Complex chromosomal changes were detected in chromosome 18 and positively identified as chromothripsis (Fig. 1).
case_images: Detailed visualization of chromothripsis affecting of chromosome 18. Array-CGH detected 6 breakpoints, 12 areas of loss and 4 areas of gain of genetic material
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case_images: PMC5774134_02_13039_2018_357_Fig2_HTML.jpg
case_images: Fig2
case_images: Mbp affected with amplification (5-6 copies) in 18q21 (Fig. 2). Moreover, in 16p13.13-16p11.2, we found another area of amplification approximately 22.5 Mb of size, harboring 259 genes spawning from SOCS1 to SLC6A10P.
case_images: Overview of 338 variants from next-generation sequencing of 62 hematooncology associated genes from Sistema Genomicos custom panel
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case_images: PMC5774134_02_13039_2018_357_Fig3_HTML.jpg
case_images: Fig3
case_images: Genomicos, Spain) showed total of 338 variants. Graphical overview of variant types is shown in Fig. 3.