case_images: PMC11729437_01
case_images: Trend of alanine transaminase (ALT), alkaline phosphatase (ALP), age, and body mass index (BMI) over time.
case_images: 10.1177_03000605241310158-fig1.jpg
case_images: PMC11729437_01_10.1177_03000605241310158-fig1.jpg
case_images: fig1-03000605241310158
case_images: Figure 1 illustrates the trend of the patient's liver enzymes over time. Figure 1 also shows her weight trend.
case_images: Liver biopsy at 200x magnification, stained with hematoxylin and eosin. The lobules show moderate predominantly macrovesicular steatosis (approximately 60%), primarily in zone 2, with focal lobular activity and occasional lymphocyte aggregates. Portal tracts exhibit no significant inflammatory infiltrates, interface hepatitis, ductopenia, granulomas, Mallory-Denk bodies, ballooning, or cholestasis. Special stains reveal pericellular fibrosis (at most Stage 1) on Masson trichome, preserved cell plate architecture on reticulin, and no hyaline globules (negative RASD staining), iron deposits (negative Perls), or copper-associated protein deposits (negative rhodamine).
case_images: 10.1177_03000605241310158-fig2.jpg
case_images: PMC11729437_01_10.1177_03000605241310158-fig2.jpg
case_images: fig2-03000605241310158
case_images: Liver biopsy (Figure 2) revealed moderate macrovesicular steatosis, focal lymphocytic lobular activity, and pericellular fibrosis, categorized as grade 1 and stage 1 according to the Brunt scoring system.