case_images: PMC10885841_01
case_images: MRI abdomen with and without contrast with MRCP. A: Coronal section shows nodular liver with cirrhotic morphology and normal gallbladder, biliary tree, and pancreas. B: The transverse section shows multiple hypoenhancing lesions such as the 2.4 x 2.47 cm on the image.. MRCP: magnetic resonance cholangiopancreatography
case_images: cureus-0016-00000052858-i01.jpg
case_images: PMC10885841_01_cureus-0016-00000052858-i01.jpg
case_images: FIG1
case_images: Subsequently, an MRI of the abdomen with magnetic resonance cholangiopancreatography (MRCP) revealed a nodular liver surface contour with a normal gallbladder, biliary tree, and bowel (Figure 1).
case_images: Histopathological analysis of liver tissue. A: High-magnification view under H&E stain accentuates the morphology of small cell neuroendocrine carcinoma. B: H&E staining depicts infiltrative small cell neuroendocrine carcinoma with reactive myxoid stromal changes and fibrosis (indicated by the arrow). C: Ki-67 immunohistochemical staining reveals elevated index in neoplastic cells, with more than 80% of them expressing this marker. D: The H&E-stained section displays the adjacent non-tumor liver parenchyma devoid of any significant fibrotic changes, with the exception of a focal region demonstrating sinusoidal invasion by small cell neuroendocrine carcinoma (highlighted by the arrow).
case_images: cureus-0016-00000052858-i02.jpg
case_images: PMC10885841_01_cureus-0016-00000052858-i02.jpg
case_images: FIG2
case_images: The liver parenchyma demonstrated reactive fibrosis, which can be attributed to the tissue's reparative response in proximity to the neoplastic growth (Figure 2).