case_images: PMC11094465_01
case_images: GDS behavior improvements due to EA intervention. (A) DA improvements; (B) DQ improvements. The horizontal axis represents behaviors, and the vertical axis indicates assessment scores. The blue bar displays the baseline assessment before EA, and the yellow bar is the 12-month follow-up assessment after EA. GDS, Gesell Developmental Scales; DA, developmental age; DQ, developmental quotient.
case_images: fpsyt-15-1392958-g001.jpg
case_images: PMC11094465_01_fpsyt-15-1392958-g001.jpg
case_images: f1
case_images: Gesell Development Scales assessment indicated extremely severe developmental delay in all of the 5 zones: adaptive behavior (Developmental Age (DA): 8.88 months, Developmental Quotient (DQ): 18 months), gross bodily control (DA: 3.51 months, DQ: 7 months), fine motor coordination (DA: 8.13 months, DQ: 17 months), language (DA: 8.75 months, DQ: 18 months), and personal-social behavior (DA: 7 months, DQ: 14 months) at baseline ( Figure 1 ). These modifications resulted in a general amelioration of the patient's condition ( Figure 1 ).
case_images: The FC-changes patterns during the two recovery phases of EA treatment: (A) the 0-3-month phase; and (B) the 3-5-month phase. The color bar indicates the magnitude of FC changes in each brain area. L, left hemisphere; R, right hemisphere.
case_images: fpsyt-15-1392958-g002.jpg
case_images: PMC11094465_01_fpsyt-15-1392958-g002.jpg
case_images: f2
case_images: We computed the main functional connectivity patterns for different recovery phase (0-month, 3-month and 5-month), respectively, and measured the difference between phases ( Figure 2 ).
case_images: Probabilistic functional profile of the two phases' FC-changes patterns based on the Neurosynth meta-analysis. Scores indicate the Pearson's correlations between each FC-changes pattern and Neurosynth topics. The blue line represents the 0-3-month phase; the yellow line represents the 3-5-month phase.
case_images: fpsyt-15-1392958-g003.jpg
case_images: PMC11094465_01_fpsyt-15-1392958-g003.jpg
case_images: f3
case_images: Phases' FC changes showed distinct functional signatures ( Figure 3 ).