case_images: PMC3303706_01
case_images: Baseline QTc. QTc interval was normal prior to amiodarone administration (day 0); after 1.65g intravenous amiodarone, QTc increased progressively.
case_images: CRIM2012-673019.001.jpg
case_images: PMC3303706_01_CRIM2012-673019.001.jpg
case_images: fig1
case_images: A 57-year-old male, with unremarkable cardiovascular history, had a self-terminated episode of atrial fibrillation (Figure 1) one day prior to surgery for hiatus hernia. Sinus rhythm was restored after 1 hour, but drug administration was continued for 12 hours, with a total amiodarone dosage of 1.65 g (Figure 1). 
case_images: Torsade de pointes after amiodarone administration.
case_images: CRIM2012-673019.002.jpg
case_images: PMC3303706_01_CRIM2012-673019.002.jpg
case_images: fig2
case_images: Approximately 48 hours after amiodarone administration, torsade de pointes was recorded (Figure 2) and prompt defibrillation restored sinus rhythm.
case_images: Time course of QTc prolongation. QTc prolongation persisted for 14 days after cessation of intravenous amiodarone. Note the (marginally) low serum K+ on the 4th hospital day.
case_images: CRIM2012-673019.003.jpg
case_images: PMC3303706_01_CRIM2012-673019.003.jpg
case_images: fig3
case_images: However, prolonged hospitalization was required, because QTc prolongation persisted until the 14th hospital day (Figure 3).
case_images: 12-lead ECG at discharge. Prior to discharge, the QTc interval was 470 ms.
case_images: CRIM2012-673019.004.jpg
case_images: PMC3303706_01_CRIM2012-673019.004.jpg
case_images: fig4
case_images: The patient was discharged home on the 15th hospital day, at which point a QTc interval of 470 ms was recorded (Figure 4).