case_images: PMC10955327_01
case_images: Clinical course of the patient. PSL = prednisolone; MZ = mizoribine; MMF = mycophenolate mofetil; CsA = cyclosporine; Tac = tacrolimus; CNI = calcineurin inhibitor; eGFR = estimated glomerular filtration rate; U-TP/Cr = urinary protein-to-creatinine ratio; BW = body weight; D = day.
case_images: CNCS-12-026-01.jpg
case_images: PMC10955327_01_CNCS-12-026-01.jpg
case_images: Figure1
case_images: During the 7 months of valsartan discontinuation, proteinuria reappeared, and the serum creatinine and potassium levels returned to the levels before valsartan administration (Figure 1).  During the 4 years of SGLT2 inhibitor administration, the UPCR was ~ 0.5 g/gCr, and the serum creatinine levels were ~ 2.0 mg/dL (Figure 1, Figure 2A).  Esaxerenone was administered to try to reduce urinary protein excretion, which was followed by a steep decrease in the UPCR; it was 0.313 g/gCr 3 months later and was maintained at ~ 0.5 g/gCr (Figure 1, Figure 2B). 
case_images: Clinical course of the patient. A: Before and during the administration of ipragliflozin. B: Before and during the administration of esaxerenone. eGFR = estimated glomerular filtration rate; U-TP/Cr = urinary protein-to-creatinine ratio; BW = body weight.
case_images: CNCS-12-026-02.jpg
case_images: PMC10955327_01_CNCS-12-026-02.jpg
case_images: Figure2
case_images: During the 4 years of SGLT2 inhibitor administration, the UPCR was ~ 0.5 g/gCr, and the serum creatinine levels were ~ 2.0 mg/dL (Figure 1, Figure 2A).  Esaxerenone was administered to try to reduce urinary protein excretion, which was followed by a steep decrease in the UPCR; it was 0.313 g/gCr 3 months later and was maintained at ~ 0.5 g/gCr (Figure 1, Figure 2B). 