case_images: PMC5971236_01
case_images: Axial MRI shows a 7.5 cm heterogenous mass in the right frontal lobe with T1-weighted sequences showing patchy enhancement following contrast administration (a) and hyperintensity with surrounding vasogenic edema on T2-weighted fluid attenuated inversion recovery sequences (b).
case_images: CRIOG2018-4606354.001.jpg
case_images: PMC5971236_01_CRIOG2018-4606354.001.jpg
case_images: fig1
case_images: However, magnetic resonance imaging (MRI) of the brain revealed a 7.5 cm heterogenous mass in the right frontal lobe (Figure 1) that showed patchy contrast enhancement, focal calcifications with blood products, and surrounding vasogenic edema with mild midline shift.
case_images: H&E stain shows a biphasic neoplasm characterized by dysplastic ganglion cells, including binucleate forms ((a) 400x magnification), and a hypercellular malignant glial component with nuclear atypia and increased mitotic activity ((b) 200x magnification).
case_images: CRIOG2018-4606354.002.jpg
case_images: PMC5971236_01_CRIOG2018-4606354.002.jpg
case_images: fig2
case_images: The ganglioglioma was qualified as anaplastic due to increased cellularity, nuclear atypia, and mitotic activity in the glial component (Figure 2).