case_images: PMC6694773_01
case_images: Skin purpura and kidney biopsy. A, Lower extremity purpura. B, Hematoxylin and eosin stain showing glomerular necrosis (x400). C, Periodic Schiff-Methenamine stain showing proliferation of mesangial cell and mesangial matrix (x400). D, Positive staining with kappa-light chain in the glomeruli and renal tubular epithelial cells (x400). E, Confluent, granular staining of mesangial IgA deposits (x400). F, Electron microscopy demonstrating the electron-dense deposits in the mesangial region (x5000). Scale bars in B, C, D, E: 50 mum; scale bar in F: 2 mum.
case_images: 1414-431X-bjmbr-52-7-e8222-gf001.jpg
case_images: PMC6694773_01_1414-431X-bjmbr-52-7-e8222-gf001.jpg
case_images: f01
case_images: The patient underwent a kidney biopsy in November 2017 that revealed HSP nephritis (HSPN, ISKD classified as type III, defined as focal hyperplasia and sclerosis), with isolated positive kappa-light chain and negative lambda light chain immunostaining (Figure 1).
case_images: Hematoxylin and eosin stain showing chronic inflammatory cell infiltration around small blood vessels (A, x200) and fibrous connective tissue hyperplasia (B, x400). Scale bars: 100 mum (A) and 50 mum (B).
case_images: 1414-431X-bjmbr-52-7-e8222-gf002.jpg
case_images: PMC6694773_01_1414-431X-bjmbr-52-7-e8222-gf002.jpg
case_images: f02