case_images: PMC11381236_01
case_images: illustrates the clinical features of this patient with CD, including preoperative MRI scans, the surgical excision of the tumor specimen, postoperative incision site, and H&E (hematoxylin and eosin) staining of the excised specimen. (A) Rectal mass is observed in the lower right section (white arrow), appearing as a clumped elongated T1 and T2 signal shadow, measuring approximately 31mm x 28mm x 32mm. (B) Excised mass from the sacrum: A piece of irregular gray-brown tissue, measuring 4cm in diameter, with a tough whitish texture at the incision site. (C) Postoperative incision. (D) Histopathological examination of the surgical specimen with H&E staining. The lymph nodes exhibit lymphoid follicular hyperplasia with increased vascularity in the follicular centers. The blood vessels show hyaline changes in their walls, and the germinal centers are reduced in size. Within these centers, follicular dendritic cells with vesicular nuclei display a "burned-out" appearance. The mantle zone small lymphocytes are arranged in concentric circles, resembling "onion skin" patterns.
case_images: fonc-14-1434542-g001.jpg
case_images: PMC11381236_01_fonc-14-1434542-g001.jpg
case_images: f1
case_images: Diffusion-weighted imaging (DWI) showed a high signal, and the apparent diffusion coefficient (ADC) showed a low signal, with unclear boundaries between the lesion and the adjacent lower rectum ( Figure 1A ). The mass was completely excised along the avascular plane, and bleeding points on the wound were electrocoagulated ( Figure 1B ). The incision was closed in layers ( Figure 1C ), and the surgery was completed.
case_images: Immunohistochemical staining of resected tumors. The staining results for CD3 (A), CD5 (B), CD20 (C), and CD21 (D) are provided to support the diagnosis of CD (castleman disease).The results are as follows: CD5 (positive in the interfollicular area), CD3 (positive in the interfollicular area), CD20 (partially positive), CD21 (positive in follicular dendritic cells).
case_images: fonc-14-1434542-g002.jpg
case_images: PMC11381236_01_fonc-14-1434542-g002.jpg
case_images: f2
case_images: PMC11381236_02