case_images: PMC8077659_01
case_images: Coronal and axial neck CT scan with contrast.
case_images: cro-0014-0641-g01.jpg
case_images: PMC8077659_01_cro-0014-0641-g01.jpg
case_images: F1
case_images: Neck and thorax computed tomography (CT) scan with contrast (Fig. 1) showed a heterogeneously enhancing mass lesion in the left side of the larynx predominantly involving the glottic compartment and measuring approximately 1.8 x 1.5 x 1.1 cm in size.
case_images: Intraoperative image of the mass as it appears under micro-laryngoscopy.
case_images: cro-0014-0641-g02.jpg
case_images: PMC8077659_01_cro-0014-0641-g02.jpg
case_images: F2
case_images: The patient underwent micro-laryngoscopy (Fig. 2) with biopsy and debulking of the mass.
case_images: Low-power view of the tumor composed of pleomorphic malignant spindle cells. Note the overlying nonatypical squamous mucosa on the top right aspect of the image (HE, x10).
case_images: cro-0014-0641-g03.jpg
case_images: PMC8077659_01_cro-0014-0641-g03.jpg
case_images: F3
case_images: Specimen histopathology showed "fragments of partly ulcerated squamous mucosa with extensive underlying infiltration by a malignant neoplasm, composed of pleomorphic spindle cells, interspersed by numerous histiocytes." The malignant spindle cells exhibit frequent mitosis, including atypical mitosis; immunohistochemical stains were positive for smooth muscle actin (SMA), vimentin, and CD68 (in histiocytes), findings consistent with undifferentiated pleomorphic sarcoma (Fig. 3, 4).
case_images: High-power view of the tumor showing marked nuclear pleomorphism with frequent mitoses (black arrow) (HE, x40).
case_images: cro-0014-0641-g04.jpg
case_images: PMC8077659_01_cro-0014-0641-g04.jpg
case_images: F4
case_images: Specimen histopathology showed "fragments of partly ulcerated squamous mucosa with extensive underlying infiltration by a malignant neoplasm, composed of pleomorphic spindle cells, interspersed by numerous histiocytes." The malignant spindle cells exhibit frequent mitosis, including atypical mitosis; immunohistochemical stains were positive for smooth muscle actin (SMA), vimentin, and CD68 (in histiocytes), findings consistent with undifferentiated pleomorphic sarcoma (Fig. 3, 4).