case_images: PMC11756168_01
case_images: Tacrolimus blood levels in a rheumatoid arthritis patient treated with ensitrelvir. TAC and ensitrelvir doses, and laboratory parameters are presented. TAC, tacrolimus; Scr, serum creatinine; ALT, alanine aminotransferase. The time (h) in parentheses indicates the interval between the last TAC dose and the TDM measurement
case_images: 40780_2025_411_Fig1_HTML.jpg
case_images: PMC11756168_01_40780_2025_411_Fig1_HTML.jpg
case_images: Fig1
case_images: TAC level was 2.7 ng/mL at 7:00 (35.5 h after the last dose), while on day 2, TAC level was 1.7 ng/mL at 7:00 (83.5 h after the last dose). TAC level on day 5 (the next day after the end of ensitrelvir treatment) was reduced to 1.1 ng/mL at 7:00 (155.5 h after the last dose) (Fig. 1). TAC dose to 1.5 mg daily. During ensitrelvir treatment, alanine aminotransferase (ALT) and Scr levels remained within normal ranges (Fig. 1). The SARS-CoV-2 PCR Ct values on days 0, 5, 12, and 19 were 25.88, 30.03, 34.36, and 34.89, respectively, indicating a decrease in the viral load.