case_images: PMC10601855_01
case_images: Plasma levels of clozapine and its metabolite norclozapine during the course of continuous veno-venous hemodiafiltration (CVVHDF) + CytoSorb hemoadsorption treatment. The dashed line indicates the expected (calculated) spontaneous elimination considering the half-life period of both compounds (assuming linear kinetics even in high concentrations). Each CytoSorb treatment was run for 12 h.
case_images: cnd-2023-0013-0001-531130_F01.jpg
case_images: PMC10601855_01_cnd-2023-0013-0001-531130_F01.jpg
case_images: F1
case_images: Systemic clozapine drug concentration before initiation of combined CVVHDF and hemoadsorption was 4,779 ng/mL (see first value pre-adsorber) and serial measurements confirmed rapid reduction of clozapine plasma levels (Fig. 1).