case_images: PMC10957748_01
case_images: Ultrasound(US): bilateral mammary glands were irregular and flaky, local tissues were thickening, and there is structural disorder. There are several regular-shaped and well-circumscribed hypoechoic masses with envelope in her both breasts. CDFI: there was no obvious blood flow signal. Bilateral axillary lymph nodes were not palpable.
case_images: fonc-14-1354152-g001.jpg
case_images: PMC10957748_01_fonc-14-1354152-g001.jpg
case_images: f1
case_images: Ultrasound (US) examination revealed multiple hypoechoic masses with clear borders and smooth margins (as shown in  Figure 1 ).
case_images: Morphological features: (A) one of the fibroadenomas in the right breast with intra-ductal epithelial hyperplasia, partly monoclonal sieve-like hyperplasia (arrows). (B) Several scattered tubules are observed in the surrounding stroma. Scale bars: (A) 80 mum; (B) 40 mum.
case_images: fonc-14-1354152-g002.jpg
case_images: PMC10957748_01_fonc-14-1354152-g002.jpg
case_images: f2
case_images: Routine sections of the tissue samples showed that almost all of the nodules were conventional fibroadenomas, except for one nodule in the right breast that exhibited atypical ductal hyperplasia (as shown in  Figure 2A ). In the surrounding stroma, there were several scattered tubules that were partially absent in the myoepithelium (as shown in  Figure 2B ).
case_images: Immunohistochemical findings: CK14 (A) and Calponin (B) were preservative at the periphery of atypical ductal hyperplasia (red arrow), but were partly absent at scattered tubules in the surrounding stroma (black arrows). S100 protein was negative (C). Collagen IV evidenced a continuous layer of basal lamina surrounding the glands (D). Scale bars: (A-C) 80 mum; (D) 40 mum.
case_images: fonc-14-1354152-g003.jpg
case_images: PMC10957748_01_fonc-14-1354152-g003.jpg
case_images: f3
case_images: Immunohistochemical staining for P63, SMA, CK5/6, and CK14 (as shown in  Figure 3A ) and Calponin (as shown in  Figure 3B ) confirmed this finding. S100 protein staining was negative (as shown in  Figure 3C ). Collagen IV evidenced a continuous layer of basal lamina surrounding the glands (as shown in  Figure 3D ).