case_images: PMC10618416_01
case_images: Computed tomography images (A, B) and enhanced magnetic resonance images (C-H) of the case.
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case_images: PMC10618416_01_fonc-13-1278300-g001.jpg
case_images: f1
case_images: It implied that the possible malignant pelvic tumor from the ovary may be an abdominopelvic cavity with a large amount of fluid or a small ascending colon diverticulum ( Figures 1A, B ). It revealed a huge malignant pelvic space, possibly originating from the ovary, a large amount of fluid in the abdominopelvic cavity, and multiple nasal cysts in the cervix ( Figures 1C-H ).
case_images: The pathological feature of the case. (A) The tumor is solid and nodular, with the umbilical end of the fallopian tube seen as a nodule on the surface (arrows). (B) The tumor is grayish dark red, solid, and has honeycombing in some areas. (C) Hematoxylin and eosin (HE) stain showing the epithelial component of the tumor (predominantly plasmacytoid carcinoma). (D) HE stain showing the poorly differentiated epithelial and mesenchymal components within the tumor (chondrosarcoma). Immunohistochemical findings: (E) epithelial component CK (+); (F) tumor cell p16 (+); (G) tumor cell p53 (+); (H) tumor cell WT-1 focal (+); (I) tumor cell ER foci (+); (J) PR part (+); (K) Her-2 (1+); (L) CK7 fraction (+); (M) CK20 foci (+); (N) c-kit foci (+); (O) SMA part (+); (P) desmin foci (+).
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case_images: PMC10618416_01_fonc-13-1278300-g002.jpg
case_images: f2
case_images: Postoperative gross pathological observation showed the following: right adnexa, soft, grayish dark red nodular mass measuring 14 cm x 12 cm x 8 cm with honeycombing in some areas; attached fallopian tube measuring 3 cm long, 5 cm in diameter; and nodular umbrella end measuring 2 cm x 2 cm x 1.5 cm with a medium texture ( Figures 2A, B ). Microscopically, the right ovarian mass showed plasma carcinoma with a poorly differentiated epithelial component; the mesenchymal component was chondrosarcoma ( Figures 2C, D ). The immunophenotyping of the right ovarian mass was as follows: ovarian tumor cells CK fraction (+) ( Figure 2E ), vimentin fraction (+), CK5/6 foci (+), p16 (+) ( Figure 2F ), p53 in approximately 70% (+) ( Figure 2G ), WT-1 foci (+) ( Figure 2H ), ER foci (+) ( Figure 2I ), PR part (+) ( Figure 2J ), Her-2 (1+) ( Figure 2K ), CK7 fraction (+) ( Figure 2L ), CK20 foci (+) ( Figure 2M ), CD99 fraction (+), CD10 fraction (+), CD56 foci (+), c-kit foci (+) ( Figure 2N ), SMA part (+) ( Figure 2O ), desmin foci (+) ( Figure 2P ), PD-L1 (-), SALL4 (-), OCT3/4 (-), p63 (-), p40 (-), D2-40 (-), inhibin (-), PLAP (-), CD30 (-), and Ki67 hotspot in approximately 80% (+).
case_images: A timeline figure summarising the case diagnosis and treatment pathway.
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case_images: PMC10618416_01_fonc-13-1278300-g003.jpg
case_images: f3
case_images: To control the development of the disease and prolong the patient's survival period, the proposed postoperative treatment was intravenous chemotherapy of albumin paclitaxel (400 mg) + carboplatin (500 mg) on day 1, every 21 days for six courses, and the first chemo treatment is April 14th ( Figure 3 ).