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case_images: The timeline of the patient's disease progression and medication history. The cross indicates the timepoint when the patient discontinued the medication, two months prior to the manic episode. The hollow circle indicates the patient took the medication intermittently.
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case_images: The detailed timeline of the disease course is presented in  Figure 1 .
case_images: The MRI images of the patients. (A-C) conventional structural MRI, including T2-weighted (A), T2-weighted and fluid-attenuated inversion recovery imaging (B), and T1-weighted (C), revealed no visible abnormalities. (D, E) indicate quantitative structural magnetic resonance imaging (qsMRI). The illustrations in (D) (the first scan, May 25,2023) and (E) (the second scan, Dec 19,2023) represent changes in the subcortical structures relative to the normative reference. The blue color indicates that the volume of the corresponding brain region was below the normative modeling charts for the corresponding age and sex, whereas the red color indicates a higher volume. A relatively lower volume of bilateral hippocampi was observed in (D) and recovery to normal level in (E).
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case_images: Conventional magnetic resonance imaging (MRI) revealed no intracranial abnormalities, while quantitative structural MRI (qsMRI) showed bilateral reductions in hippocampal volume ( Figure 2 ).
case_images: The PET/MRI images of the patient. 18F-AV45 PET/MRI showed no significant cortical Abeta deposition.
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case_images: The results indicated no abnormal cortical Abeta deposition in the brain ( Figure 3 ).
case_images: The changes in the hippocampal volume from qsMRI of the patient. The bar chart demonstrates the volume (mm3) of the bilateral hippocampus at two time point. The four dashed lines represent the normative lower and upper limits of the left hippocampus and right hippocampus for the corresponding age and sex, respectively.
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case_images: Furthermore, his bilateral hippocampal volume showed an increase compared to baseline, now falling within the normal range ( Figure 4 ).