case_images: PMC3988652_01
case_images: Radiography showing a radiolucent area with bone resorption between teeth 22 and 26
case_images: JISP-18-85-g001.jpg
case_images: PMC3988652_01_JISP-18-85-g001.jpg
case_images: F1
case_images: The radiographic examination showed the presence of a unilocular radiolucent area between the left superior lateral incisor and the first left molar [Figure 1].
case_images: Lesion surgical enucleation and extraction of tooth 26
case_images: JISP-18-85-g002.jpg
case_images: PMC3988652_01_JISP-18-85-g002.jpg
case_images: F2
case_images: An incisional biopsy was performed; removing all the granulomatous tissue present in the area and tooth 25 was removed, as it was decayed [Figure 2].
case_images: Specimen for histopathological analysis tooth 26
case_images: JISP-18-85-g003.jpg
case_images: PMC3988652_01_JISP-18-85-g003.jpg
case_images: F3
case_images: The specimen was sent for histopathological analysis [Figure 3].
case_images: (a) Histological features of the biopsy specimen showing cellular connective tissue and presence of multiple islands and strands of odontogenic epithelium (Hematoxylin-eosin stain; original magnification x400). (b) Immunohistochemical reaction for AE1/AE3 : positive staining for odontogenic epithelium (original magnification x400)
case_images: JISP-18-85-g004.jpg
case_images: PMC3988652_01_JISP-18-85-g004.jpg
case_images: F4
case_images: The microscopic examination revealed a cellular connective tissue with multiple islands and strands of odontogenic epithelium covered by stratified squamous epithelium [Figure 4a]. Immunohistochemical reactions for AE1/AE3 showed positive staining for an odontogenic epithelium, confirming the central odontogenic fibroma WHO-type diagnosis [Figure 4b].