case_images: PMC11745554_01
case_images: Clinical photograph of a Bernese Mountain Dog with vitiligo, uveal depigmentation, and anterior uveitis. Periocular alopecia, skin depigmentation, and leukotrichia are present in OU. Skin depigmentation of the lips, nasal bridge, and nasal planum is present with multifocal areas of bilateral pinnal leukotrichia.
case_images: CRIVEM2025-6586766.001.jpg
case_images: PMC11745554_01_CRIVEM2025-6586766.001.jpg
case_images: fig1
case_images: In addition, skin and hair depigmentation was noted around the lips, nose, and muzzle (Figure 1).
case_images: Clinical photograph of the right (a) and left (b) eyes of a Bernese Mountain Dog with vitiligo, uveal depigmentation, and anterior uveitis. Periocular alopecia, skin depigmentation, and leukotrichia are present in OU. Multifocal, faint subepithelial white crystalline deposits are present in the axial cornea in OU. Multifocal posterior synechiae and dyscoria are observed with peripheral iris depigmentation in OU. Multifocal, punctate pigment is present on the anterior lens capsule in OU.
case_images: CRIVEM2025-6586766.002.jpg
case_images: PMC11745554_01_CRIVEM2025-6586766.002.jpg
case_images: fig2
case_images: Multifocal posterior synechiae and dyscoria persisted in OU but were now associated with peripheral iris depigmentation confined to the ciliary zone of the iris (Figure 2).
case_images: Low- (a) and high-magnification (b) histopathologic photomicrographs of nasal planum cutaneous biopsies in a dog with vitiligo. There is a marked reduction in epidermal melanin. A small number of lymphocytes and melanophages surround capillaries in the superficial dermis. A small number of lymphocytes migrate into the overlying epidermis. Stained with hematoxylin and eosin. Original magnification 100x (a) and 400x (b).
case_images: CRIVEM2025-6586766.003.jpg
case_images: PMC11745554_01_CRIVEM2025-6586766.003.jpg
case_images: fig3
case_images: Mild, multifocal, chronic, lymphocytic, histiocytic, superficial, and perivascular dermatitis with mild pigmentary incontinence and segmental epidermal depigmentation were present in all evaluated samples (Figure 3).