case_images: PMC10775796_01
case_images: Clinical findings as pruritic multiple papules overlying the lichenified plaque prior to treatment.
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case_images: Her vulvar skin condition started 2 months before consultation, initially presenting as dark spots in the labia majora (Figure 1).
case_images: Histopathological examination from the labia majora revealed stromal lymphocytic infiltration.
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case_images: HPV-66 was detected by PCR. However, histopathological examination revealed stromal lymphocytic infiltration with non-specific chronic dermatitis, and neither atypia nor koilocytes was observed (Figure 2).
case_images: The result of immunohistochemical-staining. (A) Patchy p16 IHC staining was interpreted as p16-negative. (B) Weak and patchy p53 IHC staining was interpreted as p53-negative.
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case_images: IHC of both p16 (Figure 3A) and p53 (Figure 3B) showed negative results.
case_images: Clinical improvement was observed as the lesion became hyperpigmented macules without itching in the four weeks of follow-up.
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case_images: In the 4 weeks of follow-up, clinical improvement was observed as the lesions became hyperpigmented macules without itching (Figure 4).