case_images: PMC10233053_01
case_images: Ocular findings in the case carrying m.4135T>C. Fundus photograph of the right (A) and left eyes (B) documenting pallor (atrophy) of the optic discs. Thinning of the retinal nerve fiber layer in the right (C) and left (D) eyes in the temporal quadrants at baseline examination corresponding to thinning of the ganglion cell layer (red areas) (E,H) in the macular region, peripapillary capillary dropout (F,I) and centrocecal scotoma more pronounced on the right (G) than in the left (J) eye. Follow-up examination 21 months later, retinal nerve fiber layer in the right (K) and left (L) eyes, ganglion cell layer in the right (M) and left (P) eyes, bilateral peripapillary capillary dropout (N, Q), and visual field defect in the right (O) and left (R) eyes; no marked progression was observed.
case_images: fgene-14-1182288-g001.jpg
case_images: PMC10233053_01_fgene-14-1182288-g001.jpg
case_images: F1
case_images: Fundus examination revealed pallor of the optic disc bilaterally (Figure 1). Visual field defects remained stable, as well as the reduction of RNFL in temporal fields bilaterally (Figure 1).