case_images: PMC10790811_01
case_images: Imaging and histopathology. (A) Cardiac magnetic resonance demonstrating lobulated interatrial mass (white arrow); (B) Positron emission tomography scan demonstrating moderate fluorodeoxyglucose (FDG) uptake within the interatrial septum (black arrow). The scan was performed 60 min post intravenous administration of 282 MBq of FDG; (C) Haematoxylin and eosin stain demonstrating brown adipose and native mature adipose tissue; (D) Fluorescent in situ hybridisation demonstrating normal signal without amplification of mouse double minute 2 locus.
case_images: ytad612f1.jpg
case_images: PMC10790811_01_ytad612f1.jpg
case_images: ytad612-F1
case_images: Figure 1A demonstrates the interatrial septal mass was lobulated, extending posteriorly and superiorly into the pericardial space. As shown in Figure 1B, repeat PET using a cardiac dedicated protocol (i.e. avoiding pre-scan carbohydrate) found only moderately increased metabolism compared with the previous PET imaging (SUV 6.5 vs. 12.7). The biopsy result demonstrated two fragments of cardiac muscle and one of a fatty process that included brown fat and mature appearing adipocytes, as seen in Figure 1C. Figure 1D demonstrates that fluorescence in situ hybridisation testing (FISH) testing for mouse double minute 2 (MDM2) was negative (sensitivity of about 99% in atypical lipomatous tumours or well-differentiated and de-differentiated liposarcoma).