case_images: PMC10072263_01
case_images: Multiple hyperpigmentations were visible on the skin. (A) hands. (B) right foot. Gastrointestinal endoscopy revealed multiple polyps. (C) small bowel. (D) ileum.
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case_images: PMC10072263_01_fmed-10-1094839-g001.jpg
case_images: fig1
case_images: In addition, several melanin pigments were observed on the tips of the patient's fingers, lips, and feet (Figures 1A,B). We found several adenomatous polyps of different sizes scattered throughout the gastrointestinal tract (Figures 1C,D).
case_images: Magnetic resonance imaging (MRI) images showing an enlargement of the cervix with multiple cystic lesions. (A) coronal plane. (B) sagittal plane. (C) transverse plane. (D) Gross features of the uterus showing bulging cervix, fallopian, and ovary. The arrows show bilateral ovaries.
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case_images: PMC10072263_01_fmed-10-1094839-g002.jpg
case_images: fig2
case_images: The mass was confined to the cervix without parametrial involvement, and there was no evidence of metastatic lymphadenopathy (Figures 2A-C). Both ovaries were cystic and multilocular (approximately 4 x 3 x 1.5 cm; Figure 2D).
case_images: (A,B) Gastric-type endocervical adenocarcinoma (G-EAC) in cervix (H&E, x 40, x 100); (C,D) Deep stroma infiltrated with G-EAC (H&E, x 40, x 100); (E,F) The tumor cells of annular tubular cord tumors of the ovary are arranged into annular tubules, and the nuclei are polar overturned (H&E, x 100).
case_images: fmed-10-1094839-g003.jpg
case_images: PMC10072263_01_fmed-10-1094839-g003.jpg
case_images: fig3
case_images: A variety of morphological glands were in the cervical interstitium (Figures 3A,B). The cellular atypia was not obvious. The deep stroma was infiltrated with G-EAC (Figures 3C,D). Besides, the nucleus was polarly reversed, close to the luminal surface with hyaline bodies around (Figures 3E,F).
case_images: (A) HIK1083 (Positive); (B) P16 (negative); (C) Ki67 (60%positive); (D) p53 (wild type). All immunohistological (IHC) were x 100.
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case_images: PMC10072263_01_fmed-10-1094839-g004.jpg
case_images: fig4
case_images: (A) ER (positive); (B) PR (negative); (C) Inhibin (positive); (D) Calretinin (positive). All IHC were x 100.
case_images: fmed-10-1094839-g005.jpg
case_images: PMC10072263_01_fmed-10-1094839-g005.jpg
case_images: fig5
case_images: IHC (Figures 5C,D): Inhibin (positive), Calretinin (positive).