case_images: PMC7568228_01
case_images: Hyperchromatic-crowded groups (a and b) adjacent to benign squamous cells (PAP, x40), (c) hyperchromatic-crowded group with intracytoplasmic mucin (PAP, x40), (d) The biopsy specimen showed cribriform/microacinar architecture with confluent neoplastic glands (H and E, x40).
case_images: Cytojournal-17-17-g001.jpg
case_images: PMC7568228_01_Cytojournal-17-17-g001.jpg
case_images: F1
case_images: The cells showed high nuclear-cytoplasmic ratios, hyperchromatic nuclei with coarse chromatin, nuclear membrane irregularities, ill-defined cell borders, and prominent nucleoli [Figure 1].
case_images: (a and b) Angulated, fragmented, infiltrative, and irregularly shaped glands with a conspicuous desmoplastic reaction (H and E, x4 and x10). (c and d) Malignant fused glands with cribriform architecture and a neutrophilic infiltrate (H and E, x10 and x40).
case_images: Cytojournal-17-17-g002.jpg
case_images: PMC7568228_01_Cytojournal-17-17-g002.jpg
case_images: F2
case_images: HCG. High-risk human papillomavirus (HPV) test was positive in this patient, and endocervical curettage with cervical biopsy revealed the findings shown in Figure 2.
case_images: Immunohistochemistry for p16, monoclonal carcinoembryonic antigen, estrogen receptor, and progesterone receptor.
case_images: Cytojournal-17-17-g003.jpg
case_images: PMC7568228_01_Cytojournal-17-17-g003.jpg
case_images: F3
case_images: The tumor cells showed nuclear immunoreactivity for p16 with monoclonal carcinoembryonic antigen (mCEA) immunoreactivity but nonimmunoreactivity for estrogen receptor (ER), progesterone receptor (PR), and vimentin [Figure 3].