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case_images: Clinical patient photographs of the front of body (A), back and buttocks (B), axilla (C), groin (D), and scalp (E).
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case_images: Her physical examination revealed phrynoderma-like lesions on the arms, trichodysplasia spinulosa-like lesions involving the nose, widespread reticular scarring, and knuckle pads raising suspicion of a genetic syndrome affecting the cornification process (Fig 1, A-E).
case_images: Hematoxylin and eosin stain of biopsy specimen obtained from left upper back. (Original magnifications: A, x40; B, x100.)
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case_images: The biopsy of the tunnels and nodules was consistent with HS (Fig 2, A, B).
case_images: A, NanoString platform results displaying our patient's tissue signature consistent with HS with overlapping characteristics of psoriasis and pyoderma gangrenosum. B, Gene expression heatmap displaying similarities between our patient's and psoriasis patient samples.
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case_images: A). A gene expression heatmap revealed close clustering between the patient's sample and psoriasis samples (Fig 3, B).
case_images: Normalized gene expression counts comparing our patient to healthy, psoriasis, and HS patients analyzed via NanoString platform.
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case_images: fig4
case_images: IL-18 in the patient sample was significantly elevated, along with IL-17A and IL-17F compared with HS and psoriasis samples previously analyzed. IL1A and IL1B expression did not differ significantly from healthy controls (Fig 4).