case_images: PMC11444069_01
case_images: Violations of architectonics, areas of dystrophic hepatocytes separated by fields of proliferating bile ducts, most of which are in the form of tubular structures. Hemorrhage foci. Pronounced inflammatory infiltration. G.E. x 40.
case_images: IMCRJ-17-801-g0001.jpg
case_images: PMC11444069_01_IMCRJ-17-801-g0001.jpg
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case_images: The pathohistological study revealed changes in the liver, which were characterized by the following changes: the beam structure is absent, the parenchyma with disturbed architecture due to widespread massive necrosis (Figure 1).
case_images: Portal fibrosis. Trichrome Azan.x 20.
case_images: IMCRJ-17-801-g0002.jpg
case_images: PMC11444069_01_IMCRJ-17-801-g0002.jpg
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case_images: When carrying out a histochemical reaction with Azan, soft-fibrous fibrosis in the parenchyma is noted (Figure 2).
case_images: CK 7 (cytokeratin) ductular proliferation, with the formation of functionally incapable ducts, they are narrow and filled with proliferating or destructive epithelium (x20).
case_images: IMCRJ-17-801-g0003.jpg
case_images: PMC11444069_01_IMCRJ-17-801-g0003.jpg
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case_images: In immunohistochemical reactions with cytokeratin, the expression of biliary epithelium in the parenchyma in the form of false bile ducts is noted (Figure 3).
case_images: Expression of CD45 in the cells of inflammatory polymorphic cellular infiltrate (x20).
case_images: IMCRJ-17-801-g0004.jpg
case_images: PMC11444069_01_IMCRJ-17-801-g0004.jpg
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case_images: Immunohistochemical reaction with CD45 and CD68 - diffuse expression of lymphocytic and macrophage cells in the parenchyma (Figures 4 and 5).
case_images: Expression of CD68 in cells of the macrophage line (x40).
case_images: IMCRJ-17-801-g0005.jpg
case_images: PMC11444069_01_IMCRJ-17-801-g0005.jpg
case_images: f0005
case_images: Immunohistochemical reaction with CD45 and CD68 - diffuse expression of lymphocytic and macrophage cells in the parenchyma (Figures 4 and 5).