case_images: PMC5824500_01
case_images: (a) Clinical image showing a tan-red exophytic, lobulated mass of the maxillary anterior facial gingiva. (b) A separate, similar appearing smaller lesion was identified in the right maxillary vestibule
case_images: JOMFP-22-102-g001.jpg
case_images: PMC5824500_01_JOMFP-22-102-g001.jpg
case_images: F1
case_images: The lesion measured 3.0 cm x 1.5 cm in greatest dimension and appeared dark-red color with secondary tan-gray ulceration [Figure 1a]. A smaller, similar appearing lesion was identified in the right maxillary vestibule adjacent to the labial frenum [Figure 1b].
case_images: Periapical radiograph showing no changes in the quality or quantity of bone and no evidence of odontogenic infections
case_images: JOMFP-22-102-g002.jpg
case_images: PMC5824500_01_JOMFP-22-102-g002.jpg
case_images: F2
case_images: A periapical radiograph of the area showed no changes in the quality or quantity of bone and no evidence of tooth-related infections [Figure 2].
case_images: (a) Histopathologic image showing tumor cell nests completely effacing the lamina propria, (H&E, x40). (b) These tumor nests were arranged in lobular aggregates separated by thin fibrous septae, (H&E, x100). (c) On high power magnification, the cells displayed pink to vacuolated cytoplasm with vesicular nuclei and prominent nucleoli. Significant nuclear pleomorphism was present and the lesion demonstrated brisk mitotic activity, (H&E, x400)
case_images: JOMFP-22-102-g003.jpg
case_images: PMC5824500_01_JOMFP-22-102-g003.jpg
case_images: F3
case_images: Beneath the epithelium, tumor cells were found to completely efface the lamina propria [Figure 3a]. These cells were predominately arranged in lobular aggregates separated by thin fibrous septae [Figure 3b]. Significant nuclear pleomorphism was present and the lesion demonstrated brisk mitotic activity [Figure 3c].
case_images: Histopathologic image showing strong positivity for (a) pan-cytokeratin, x40, (b) CK8/18, x40, (c) Pax-8, x40, (d) CD10, x40, (e) CA9, x40, (f) CK19, x40 and (g) vimentin, x40, in the tumor cell population
case_images: JOMFP-22-102-g004.jpg
case_images: PMC5824500_01_JOMFP-22-102-g004.jpg
case_images: F4
case_images: The tumor cells were strongly positive for pancytokeratin, CK8/18, Pax-8, CD10, CA9, CK19 and vimentin [Figure 4a-g] and were focally positive for EMA.