case_images: PMC10880017_01
case_images: The images display the abdominal CT (A) and MRI (B) before surgery, showing multiple liver nodules.
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case_images: Accordingly, computed tomography (CT) and magnetic resonance imaging (MRI) examinations were regularly performed to monitor the health condition ( Supplementary Table S1 ), revealing several fast-growing masses in the liver ( Figure 1 ). Nevertheless, a new 2.1 x 1.5 cm2 mass was detected in the spleen by MRI monitoring on December 3 in 2021 ( Supplementary Figure S1 ) in Tongji Hospital.
case_images: The post-operative liver pathological observations show a liver combined with an immunophenotype consistent with a NET. The imaging techniques include H&E (Conventional HE staining), CgA (Immunohistochemistry CgA), Syn (Immunohistochemistry Syn), Scale bar of 50 mum. The automatic immunohistochemical staining experiment was performed on the Dako Autostainer link 48 (Elabscience Biotechnology Inc. Houston, TX, USA) instrument with appropriate Elabscience   RTU antibodies.
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case_images: The patient had a positron emission tomography/X-ray computed tomography (PET-CT) whole-body examination on December 5, 2017, and exhibited no significant lesions in other parts of the body except the liver ( Figure 2 ).
case_images: The images show the abdominal CT (A) and MRI (B) after surgery, showing growing lesions in the residual liver.
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case_images: Further, a CT follow-up scan was performed on December 11, 2019, in Tongji Hospital, revealing a post-operative alteration and several metastases in the residual liver ( Figure 3A ). However, a rapidly progressing 1.7 x 0.9 cm2 mass with a high DWI signal in the subcapsular posterior inferior segment of the right hepatic lobe was observed by MRI screening on July 28, 2020, in Tongji Hospital ( Figure 3B ).
case_images: The images display the abdominal CT (A) and MRI (B) after a combination treatment of TACE, anti-PD-1 antibodies, and apatinib, showing that the liver metastasis of NETs diminished significantly.
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case_images: Further, the regular CT follow-up scans revealed the diminished hepatic tumor sizes in the residual liver, confirming a critical pharmacodynamic response to the combination therapy ( Figure 4 ).