case_images: PMC10900756_01
case_images: Schematic representation of ANK3-RET fusion detected. Both genes are located on chromosome 10 (upper graph). The detected fusion occurs as depicted in central graph linking ANK3 (exon 1-33) to RET (exon 12-20) given a chimeric protein (below). Breakpoint area is enlarge showing nucleotide sequence and coding aminoacids.
case_images: fonc-14-1307458-g001.jpg
case_images: PMC10900756_01_fonc-14-1307458-g001.jpg
case_images: f1
case_images: The gene fusion detected generates a chimeric protein ANK3-RET composed of the amino-terminus of ANK3 and the carboxyl-terminus of RET, including its kinase domain as depicted in  Figure 1 .
case_images: Patient's clinical course.
case_images: fonc-14-1307458-g002.jpg
case_images: PMC10900756_01_fonc-14-1307458-g002.jpg
case_images: f2
case_images: The patient is still under Selpercatinib treatment at 160mg plus 80mg daily dosage.  Figure 2  represents the patient's clinical course.