case_images: PMC9893407_01
case_images: Pathology images and immunotherapy staining images of this patient in March 2020. (A) Pathology images of core needle biopsy. (B) ER immunotherapy staining image of core needle biopsy. (C) PR immunotherapy staining image of core needle biopsy. (D) HER2 immunotherapy staining image of core needle biopsy. (E) Ki-67 immunotherapy staining image of core needle biopsy.
case_images: fonc-12-980635-g001.jpg
case_images: PMC9893407_01_fonc-12-980635-g001.jpg
case_images: f1
case_images: The pathological biopsy results of the maximal mass showed invasive ductal carcinoma ( Figure 1A ). HER2 (3+), GCDEF-15(+) ( Figures 1B-E ).
case_images: (A) Head MRI of the maximal mass in the left frontal lobe of the brain in April 2020. (B) Head MRI of the maximal mass in the left frontal lobe of the brain in May 2020. (C) Head MRI of the maximal mass in the left frontal lobe of the brain in August 2020. (D) Head MRI of the maximal mass in the left frontal lobe of the brain in April 2022.
case_images: fonc-12-980635-g002.jpg
case_images: PMC9893407_01_fonc-12-980635-g002.jpg
case_images: f2
case_images: Head magnetic resonance imaging (MRI) revealed multiple masses in brain parenchyma, the diameter of the maximal mass was 2 cm, located in the left frontal lobe of the brain ( Figure 2A ). Her serum cancer antigen 15-3 (CA15-3) was 126.1 U/ml (normal, <31 U/ml) while serum carcinoembryonic antigen (CEA) and serum cancer antigen 12-5 (CA12-5) were both in the normal level. Head MRI revealed that the diameter of the maximal mass in the left frontal lobe of the brain was reduced to 1.2 cm ( Figure 2B ). During this treatment, her breast mass showed continuous reduction and disappeared since the seventh course in ultrasound; the diameter of the maximal mass in the left frontal lobe of the brain reduced to 1.0 cm ( Figure 2C ) since the sixth course and the other small masses in the brain were completely relieved. The latest treatment evaluation was carried out in April 2022, the mass in brain was stable, and no new lesion was discovered (Figure 2D).
case_images: PET-CT showed multiple masses in the right axilla, right supraclavicular region, and spleen in March 2020.
case_images: fonc-12-980635-g003.jpg
case_images: PMC9893407_01_fonc-12-980635-g003.jpg
case_images: f3
case_images: PET-CT was then recommended and revealed multiple masses in the right axilla, right supraclavicular region, spleen, and brain ( Figure 3 ).