case_images: PMC7712452_01
case_images: (a) Laryngoscopy revealed laryngeal mucosa hyperaemia and milky hyperplastic lesion in the bilateral vocal cords. (b) Laryngoscopy revealed the laryngeal mucosa without hyperaemia, and the hyperplastic lesion in the vocal cords completely disappeared after the patient underwent a 1-year standard anti-tuberculosis therapy.
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case_images: The laryngoscopy revealed laryngeal mucosa hyperaemia and milky hyperplastic lesion in the bilateral vocal cords (Figure 1a). After 1 year of well-tolerated treatment, the patient recovered, and the hyperplastic lesion in the vocal cords completely disappeared under laryngoscopy (Figure 1b).
case_images: (a) Original magnification x200. Histological analysis of the biopsy specimen from the vocal cords revealed granulomas with inflammatory cell infiltration in the squamous epithelium and interstitial tissue. (b) The result of the acid-fast stain for vocal cord biopsy was negative.
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case_images: Histological analysis of the biopsy specimen from the vocal cords revealed granulomas with inflammatory cell infiltration in the squamous epithelium and interstitial tissue (Figure 2a) and negative results of periodic acid-Schiff stain (PAS), acid-fast stain (Figure 2b), and Gomori methenamine silver stain (GMS).
case_images: (a) Identification of bacteria by mycobacteria gene chips showed Mycobacterium tuberculosis. (b) Identification of rifampin-resistant gene detected by mycobacteria gene chips showed that 511WT, 513WT, 516WT, 526WT, 531WT, and 533WT were all wild type. (c) Identification of isoniazid-resistant gene detected by mycobacteria gene chips showed that katG315 and inhA-15 were wild types.
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case_images: Tuberculosis Drug Resistance Detection Array Kit, CapitalBio Corp., China) were used to identify the bacteria and resistance genes. The results showed that MTB was positive (Figure 3a), and the detection of resistance genes indicated that rifampin and isoniazid had a wild-type genotype (Figure 3b and c).