case_images: PMC11056501_01
case_images: Magnetic resonance imaging findings: (A) Postgadolinium fat-saturation axial T1 weighted images reveal an extensive retroperitoneal mass, which measures 9.0 x 8.6 x 6.0 cm and involves the inferior portion of the vein inferior vena cava, inferior mesenteric artery, and infrarenal aorta. (B) The tumor size is reduced to 6.9 x 6.8 x 5.4 cm. (C) After 12 months of the RFA procedure, the tumor further shrinks to 7.2 x 4.8 x 4.1 cm. RFA, radiofrequency ablation.
case_images: fendo-15-1346052-g001.jpg
case_images: PMC11056501_01_fendo-15-1346052-g001.jpg
case_images: f1
case_images: Magnetic resonance imaging (MRI) revealed an extensive retroperitoneal mass, which measured 9.0 x 8.6 x 6.0 cm (208 mL) and involved the inferior portion of the inferior vena cava, inferior mesenteric artery, and infrarenal aorta ( Figure 1A ). After 2 months of the RFA procedure, the dose of doxazosin was decreased from 16 to 8 mg (50% reduction), the plasma normetanephrine level dropped to 4.6 nmol/L (79% reduction), and the tumor size decreased to 6.9 x 6.8 x 5.4 cm (88.8 mL, 57.3% reduction in volume) on MRI ( Figure 1B ). After 12 months, the tumor further shrunk to 7.2 x 4.8 x 4.1 cm (45 mL, 78.4% reduction in volume), and plasma normetanephrine decreased to 2.9 nmol/L (86% reduction) ( Figure 1C ).
case_images: Ga68-DOTATATE PET-MRI findings: (A) There is high uptake (SUVmax, 32.5) in the abdominal mass, with local invasion but without distant metastatic disease. (B) There is a significant reduction in the tumor uptake (SUVmax, 18.5) at 12 months after RFA. SUVmax, maximum standardized uptake value; RFA, radiofrequency ablation.
case_images: fendo-15-1346052-g002.jpg
case_images: PMC11056501_01_fendo-15-1346052-g002.jpg
case_images: f2
case_images: The Ga68-DOTATE PET-MRI showed a high uptake, with a maximum standardized uptake value (SUV max) of 32.5 in the abdominal mass, with local invasion but without distant metastatic disease ( Figure 2A ). Ga68-dotatate PET-MRI showed a significant reduction in the SUVmax from 32.5 to 18.5 after 12 months of the RFA ( Figure 2B ).