case_images: PMC11751236_01
case_images: Cranio-caudal (A) and Medio-lateral-oblique (B) DM views of the left breast show suspicious fine and pleomorphic microcalcifications from the upper-outer quadrant to the outer equatorial region (arrows) corresponding to ectasia ductal structures with multiple contextual hyperechogenic spots on US (C). The recombined medio-lateral-oblique CEM images (D, E) show, in addition to non-mass-like enhancement in the upper quadrants of the left breast (with a post-biopsy clip inside, E), a contrastographic impregnation of the ipsilateral NAC (arrows), highlighted in the focused magnification (F).
case_images: fonc-14-1497506-g001.jpg
case_images: PMC11751236_01_fonc-14-1497506-g001.jpg
case_images: f1
case_images: The first case ( Figure 1 ) involves a 46-year-old woman referred to our Breast Imagin Division for her annual follow-up examination.
case_images: A DCE-MRI subtraction image (A) shows an enhancement of the left nipple with a non-mass-like enhancement in the outer quadrants (arrow). The 2D and recombined medio-lateral CEM images (B, C) confirm a later inhomogeneous non-mass-like enhancement in the outer quadrants of the left breast (arrow).
case_images: fonc-14-1497506-g002.jpg
case_images: PMC11751236_01_fonc-14-1497506-g002.jpg
case_images: f2
case_images: The second case ( Figures 2 ,  3 ) concerns a 57-year-old woman who was referred to our institute due to persistent pain, swelling and eczema of the left nipple, unresponsive to several weeks of antibiotic therapy.
case_images: CEM-biopsy: 2D magnification and recombined focus (A, B) of the enhancement target in the outer quadrant of the left breast (arrow), where a vacuum-assisted biopsy was performed, followed by the clip placement (C, arrow).
case_images: fonc-14-1497506-g003.jpg
case_images: PMC11751236_01_fonc-14-1497506-g003.jpg
case_images: f3
case_images: The second case ( Figures 2 ,  3 ) concerns a 57-year-old woman who was referred to our institute due to persistent pain, swelling and eczema of the left nipple, unresponsive to several weeks of antibiotic therapy.