case_images: PMC6949674_01
case_images: Imaging. (a) Pulmonary computed-tomography (CT) scan showing diffuse bilateral infiltrates. (b) CT with intravenous contrast showing enlargement of both kidneys with bilateral renal nodules.
case_images: CRII2019-2543038.001.jpg
case_images: PMC6949674_01_CRII2019-2543038.001.jpg
case_images: fig1
case_images: Despite appropriate antibiotics and clinical improvement, thoracic CT scans revealed worsened dense infiltrates (Figure 1(a)), pleural effusions, hepatosplenomegaly and nodular lesions of both kidneys (Figure 1(b)).
case_images: Histology. (a) Lymphomatous infiltration in the bronchial mucosa (hematoxylin-eosin (HE) staining, x40). (b) Large diffuse large B-cell lymphoma (DLBCL) cells characterized by nuclei with prominent nucleoli on a background of tumoral necrosis (HE, x400). (c) CD20+ labeling of the DLBCL cells. (d) Epstein-Barr virus-encoded RNA-1 expressed by DLBCL cells.
case_images: CRII2019-2543038.002.jpg
case_images: PMC6949674_01_CRII2019-2543038.002.jpg
case_images: fig2
case_images: A new bronchoscopy with biopsies found CD20+ large lymphomatous cell infiltration (Figure 2) in bronchi. EBV, as assessed by in situ hybridization with an EBV-encoded small RNA probe, was diffusely positive in about 80% of tumor cells (Figure 2).