case_images: PMC9386060_01
case_images: Levels of urinary ALA (top left), urinary porphobilinogen (top right), erythrocyte zinc protoporphyrins (bottom left), and plasma protoporphyrins (bottom right) during 3 months of therapy with givosiran. Hemin and givosiran infusions are denoted by red and blue arrows, respectively. Unfortunately, our patient was hospitalized for a large portion of months 4-6 of givosiran therapy, thus, no subsequent levels are available.
case_images: fgene-13-867856-g001.jpg
case_images: PMC9386060_01_fgene-13-867856-g001.jpg
case_images: F1
case_images: As shown in Figure 1, ALA levels have decreased in the short term after hemin infusions but have not been sustained by givosiran treatment.