case_images: PMC7154263_01
case_images: Complete response of the right supraglottic and pharyngeal lesion, with previous compromise on the vallecula, aryepiglottic fold, and right side of the epiglottis after treatment with intensity-modulated radiotherapy plus cetuximab.
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case_images: PMC7154263_01_cro-0013-0314-g01.jpg
case_images: F1
case_images: A complete response after 4 months of initiation was observed (Fig. 1).
case_images: Oral lesions, leukocyte counts and subpopulations at the start of symptoms (A), after administration of etoposide (B), and after systemic treatment with metronomic cyclophosphamide and oral rinse with colchicine (C). D Microbiome diversity study at the same time points.
case_images: cro-0013-0314-g02.jpg
case_images: PMC7154263_01_cro-0013-0314-g02.jpg
case_images: F2
case_images: The lesions rapidly progressed, the inferior lip (with recurrent bleeding) and almost 50% of the mucosal membrane were compromised (Fig. 2A-C). Transitory pain improvement without any changes in the ulcer distribution was noted (Fig. 2B). The patient's blood lymphocyte count was measured and divided into CD8+ and CD3+ populations at different time points (at the start of symptoms, t1; after the administration of etoposide, t2; after systemic treatment with metronomic cyclophosphamide and oral rinse with colchicine, t3) (Fig. 2A-C). Shortly after the beginning of treatment, an almost complete remission of the lesions and optimal pain control was achieved (Fig. 2C).
case_images: A Oral ulcer contained and surrounded by polymorphonuclear cells and confined cell debris; outside this zone and extending diffusely throughout the lamina propria, a large number of infiltrating lymphocytes and macrophage-like cells were seen (x40). B Inflammatory cell infiltrate (CD8+ stained; antibody CONFIRM anti-CD8, SP57) associated with oral mucosa ulceration (x10).
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case_images: PMC7154263_01_cro-0013-0314-g03.jpg
case_images: F3