case_images: PMC4247000_01
case_images: Computed tomography (CT) images. (A) Pre-contrast CT revealing a large, solitary, well-defined mass in the spleen, with variable areas of necrosis and cystic degeneration. Contrast-enhanced CT revealing the progressively-enhanced cystic wall, internal septa and solid portion during the (B) hepatic arterial, (C) portal venous and (D) hepatic parenchymal phases. The areas of necrosis and cystic degeneration were non-enhancing.
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case_images: The mean CT attenuation value of the solid portion was 39 HU, while the values observed for the areas of necrosis and cystic degeneration were 21-23 HU (Fig. 1A). The areas of necrosis and cystic degeneration, however, were non-enhancing (Fig. 1B). During the portal venous and hepatic parenchymal phases, the cystic wall, internal septa and solid portion demonstrated a slight and progressive enhancement, with mean CT attenuation values of 54 HU and 63 HU, respectively (Fig. 1C and D).
case_images: Histological features. (A) Immunohistochemistry revealing the invasion of splenic red pulp tissue by pleomorphic tumor cells (hematoxylin and eosin stain; magnification, x40). Inset of A: Tumour tissue composed of plasma cells, with eccentrically situated nuclei and a mild degree of nuclear polymorphism (hematoxylin and eosin stain; magnification, x100). Immunohistochemistry revealing the presence of (B) lambda-light chain-positive and (B) kappa-light chain-negative cells.
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case_images: f2-ol-09-01-0219
case_images: In addition to a variety of binuclear cellular forms with scattered mitoses, perinuclear halos were observed in a number of the cells (Fig. 2A). Furthermore, the immunohistochemical staining was positive for lambda-light chains, but negative for kappa-light chains (Fig. 2B and C).