case_images: PMC11011641_01
case_images: Timeline of diagnosis and treatment in this case. (A) The timeline recorded essential events of the patient during hospitalization. The Orange dot indicates mNGS test, and the green dots indicate other test items and key events. (B) Trends in inflammatory indicators.
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case_images: The diagnostic and treatment timeline is displayed in Figure 1A. The inflammatory indicators of WBC count, NE count, and highly-sensitive CRP (Hs-CRP) index of the patient after admission are shown in Figure 1B. Performed blood routine and biochemical tests again on February 11, and the results showed the patient's inflammatory indicators had increased, but there was no clinical manifestation of bacterial infection, which was considered to be related to phlebitis caused by infusion (Figure 1B). After 3 weeks of treatment (March 2), the inflammatory indexes slightly increased but were lower than those on February 24 (Figure 1B); secondary infection was not considered.
case_images: The pathological images of bronchoscopy biopsy. The arrows show the position of hyphae.
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case_images: After staining, wide and diaphragm-free hyphae were observed, and the branches were irregular. (Figure 2).
case_images: Chest CT imaging changes of the patient. (A) The imaging result on February 9 shows inflammation in the upper lobe of the right lung. The arrow indicates the site of infection. (B) The imaging result was on February 16. (C) The imaging result after 13 days after treatment (February 24). (D) The imaging result after treatment (March 7) suggests that inflammation was obviously relieved. The arrow shows that the pneumonia was resolved.
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case_images: After 13 days of treatment (February 24), the HRCT results indicated reduced infectious lesions in the anterior segment of the right upper lobe compared to previous findings, albeit with increased inflammatory indicators (Figure 3). On March 7, chest HRCT results revealed a diminished and absorbed infectious lesion compared to previous assessments (Figure 3).