case_images: PMC6645694_01
case_images: Family history of patient. She did not have any family history of disease. Notes: Parents I (I-1 and I-2) and 3 siblings  (II-1, II-3, II-5) of patient (II-2) were unaffected. The 3rd sibling (II-4) died in his 40s.
case_images: NDT-15-2003-g0001.jpg
case_images: PMC6645694_01_NDT-15-2003-g0001.jpg
case_images: F0001
case_images: No additional family members were reported with similar neurodegenerative disease (Figure 1).
case_images: (A) Axial FLAIR image of the patient shows moderate atrophy in the bilateral cortices and (B) moderate atrophy in the hippocampus. (C) Coronal MRI image of patient. (D) Axial 18F-fluorbetaben positron emission tomography of the patient shows increased diffusion uptake over the bilateral cortices.
case_images: NDT-15-2003-g0002.jpg
case_images: PMC6645694_01_NDT-15-2003-g0002.jpg
case_images: F0002
case_images: The patient's MRI revealed global atrophy with medial temporal lobe and hippocampal atrophy predominance (Figures 2A-C). Aggravated diffuse brain atrophy and small vessel ischemic lesion were observed in follow-up MRI, but no specific abnormality was detected in diffusion-weighted image (DWI, Figures 2A-C). The Axial 18F-fluorbetaben positron emission tomography (FDG-PET) of the patient shows mild amyloid positivity, and increased diffusion uptake over the bilateral cortices, and increased cerebral cortex (Figure 2D.