case_images: PMC10901051_01
case_images: (a) An incisional biopsy of mandibular alveolar ridge showed well-differentiated squamous cell carcinoma (magnification 10x H&E). (b) Lateral tongue biopsy showed multiple lymphocytic aggregates within salivary gland parenchyma (magnification 10x H&E).
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case_images: Another biopsy was taken from a suspicious area on the right lateral tongue, and it showed a nonspecific ulcer plus multiple lymphocytic aggregates in the salivary gland parenchyma (Figure 1).
case_images: (a) Computed tomography (CT) scan axial section with right mandibular body lytic lesion. (b) Neck CT scan with contrast showed left level IV/supraclavicular lymphadenopathy.
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case_images: The extraosseous soft tissue extension also suggested that the tumor had invaded the surrounding tissues (Figure 2(a)). Moreover, the neck CT scan with contrast showed a left level IV/supraclavicular lymphadenopathy with a matted appearance (see Figure 2(b)).
case_images: (a) Cervical lymph node (level 1B) showing back-to-back follicular proliferation and an absent mental zone. (b) CD10, (c) Bcl2, and (d) Bcl6 immunohistochemical results showing strong cytoplasmic positivity in germinal centers (a-d: magnification 4x). (e) Low Ki67 proliferative index area (magnification 20x).
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case_images: BCL6, and BCL2 in the areas corresponding to the follicular pattern, whereas CD5 was negative, confirming the diagnosis of grade 1 or 2 follicular lymphoma of the cervical lymph nodes (Figure 3). Based on the AJCC (Americal Joint Committee on Cancer) criteria (8th edition), the OSCC was staged as PT4aN0M0.  