case_images: PMC11390469_01
case_images: Magnetic resonance imaging: (A-C) represent first MRI scan in March, 2022 and (D-F) demonstrate second MRI scan acquired two months afterwards. (A,D) Axial diffusion weighted imaging (B,E) axial apparent diffusion coefficient imaging (C,F) axial T2 fluid attenuated inversion recovery imaging. White arrows indicate the locations of apparent diffusion coefficient correlate.
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case_images: PMC11390469_01_fneur-15-1428021-g001.jpg
case_images: fig1
case_images: An outpatient MRI brain acquired at that time demonstrated evidence of gliosis and encephalomalacia in the right fronto-temporal region in a pattern compatible with TBI sequelae, as well as suggestion of restricted diffusion throughout the cortex, most pronounced in the left parietal lobe (Figures 1A-C). CJD (Figures 1D-F). Cerebrospinal fluid was drawn for RT-QuiC, 14-3-3, Phosphorylated-TAU, total-TAU, amyloid beta 42, cell count, glucose, lactate dehydrogenase, and protein levels.
case_images: PRISMA schema: diagrammatic representation of literature search utilizing PubMed database.
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case_images: PMC11390469_01_fneur-15-1428021-g002.jpg
case_images: fig2
case_images: Western blot (Figure 2), hematoxylin plus eosin stain, and immunohistochemistry analysis (Figure 3) were positive for Sporadic Creutzfeldt-Jakob disease (MV1-2).
case_images: Western blot of sCJD: proteinase K-treated prion protein detected using antibody 3F4 utilizing samples collected from the frontal lobe, occipital lobe, and cerebellum. T1 and T2 are reference samples.
case_images: fneur-15-1428021-g003.jpg
case_images: PMC11390469_01_fneur-15-1428021-g003.jpg
case_images: fig3
case_images: Western blot (Figure 2), hematoxylin plus eosin stain, and immunohistochemistry analysis (Figure 3) were positive for Sporadic Creutzfeldt-Jakob disease (MV1-2).