case_images: PMC11035806_01
case_images: Head MRI, EEG, and PRNP gene analysis. (A) Axial imaging showed hyperintense signals in the bilateral parietal-occipital and frontal lobes in the DWI with correlating hypointense signals in the ADC map. (B) Coronal imaging showed hyperintensities in the bilateral parietal-temporal lobes in the FLAIR sequence. (C) The PSWC on EEG. (D,E) Polymorphic analysis of the PRNP gene at codon 129 and 219.
case_images: fnagi-16-1379011-g001.jpg
case_images: PMC11035806_01_fnagi-16-1379011-g001.jpg
case_images: F1
case_images: The magnetic resonance angiography only reported mild arteriosclerosis, and the DWI and FLAIR revealed significant hyperintensities predominantly in the left parietal-occipital and frontal lobes, suggesting prion disease (Figures 1A, B). The EEG showed synchronous extensibility and high-amplitude (1.5-3.5 Hz) triphasic sharp waves on a background diffused with low-amplitude activities, which was more pronounced in the left hemisphere (Figure 1C). The 14-3-3 protein in the CSF was negative, and the PRNP gene polymorphic analysis showed methionine homozygous (M/M) at codon 129 and glutamate homozygous (E/E) at codon 219 (Figures 1D, E).