case_images: PMC10628584_01
case_images: MRI shows diffuse space-occupying lesions of the liver, T1WI high signal (a), T2WI low signal (b), DWI high signal (c), and unequal enhancement of foci in the arterial phase (d).
case_images: j_biol-2022-0750-fig001.jpg
case_images: PMC10628584_01_j_biol-2022-0750-fig001.jpg
case_images: j_biol-2022-0750_fig_001
case_images: PET-CT shows an increase in the SUV uptake value in multiple parts of the body (a), such as the liver and spleen (d), sternum and vertebrae (b), and other parts of the bone (c).
case_images: j_biol-2022-0750-fig002.jpg
case_images: PMC10628584_01_j_biol-2022-0750-fig002.jpg
case_images: j_biol-2022-0750_fig_002
case_images: Liver histopathology (HE x100) reveals nestlike cellular infiltration, accompanied by more pigmentation and nuclear enlargement with evident heteromorphism (a); the histopathology of pigmented nevi posterior to the left scapula (HE x100) indicates benign cutaneous nevus (b).
case_images: j_biol-2022-0750-fig003.jpg
case_images: PMC10628584_01_j_biol-2022-0750-fig003.jpg
case_images: j_biol-2022-0750_fig_003
case_images: Pathology of liver biopsy tissue: appearance: black, under the microscope: a malignancy with pigmentation (Figure 3); immunohistochemical (IHC) of paraffin section: Melan-A (++), HMB45 (++), S-100 (++), P16 (scattered+), Ki67 (about 25%), CgA (-), Syn (-), CK-P (-), BRAF (V600E) (+), indicating MM. Malignant lesions were excluded by biopsy pathology after a thorough physical examination, which revealed an oval, blue-gray pigmented nevus of approximately 0.3 cm in length and diameter on the skin posterior behind the left scapula (Figure 3).