case_images: PMC8440096_01
case_images: Antemortem image of the right eye showing lens opacity (cataract), persistent pupillary membranes, and lack of iridic granules.
case_images: CRIVEM2021-2064103.001.jpg
case_images: PMC8440096_01_CRIVEM2021-2064103.001.jpg
case_images: fig1
case_images: Ophthalmic examination in the calf was limited to the anterior segment and revealed opaque lenses consistent with cataracts, attenuation of the iridic granules, persistent pupillary membranes, and dyscoric pupils (Figure 1) bilaterally, as well as the left eye had a corneal ulcer with associated off-white infiltrate.
case_images: Both eyes sectioned dorsoventrally, showing a soft, gelatinous, irregular lens, and numerous small, linearized retinal folds. Both eyes were small for the reported age of the calf. Bar = 1 cm.
case_images: CRIVEM2021-2064103.002.jpg
case_images: PMC8440096_01_CRIVEM2021-2064103.002.jpg
case_images: fig2
case_images: Gross findings revealed bilateral wrinkling of the ventral retina, a small optic nerve, and a small, soft, opaque, malformed lens (Figure 2).
case_images: (a) Formation of Morgagnian globules and bladder cells with cystic liquefaction of the lens fibers. Posterior migration of epithelium was a prominent feature of both eyes (arrow). The lens capsule is variably wavy and irregular. Bar = 100 mum. (b) Severe retinal folding and the formation of numerous rosettes with vacuolated photoreceptors (arrowheads). A spindloid population of cells replaces the RPE (asterisk). Bar = 100 mum. (c) Optic nerve hypoplasia. Bar = 200 mum. Routine H&E.
case_images: CRIVEM2021-2064103.003.jpg
case_images: PMC8440096_01_CRIVEM2021-2064103.003.jpg
case_images: fig3
case_images: Lens epithelial cells were disorganized, variably stacked, binucleated, and spindloid with posterior migration of the epithelial layer (Figure 3(a)). The photoreceptor layer contained variably sized, discrete, clear vacuoles (Figure 3(b)). Abundant collagenous stroma replaced nerve bundles in the small optic nerve head (Figure 3(c)).
case_images: Scattered intrahistiocytic and endothelial immunoreactivity to BVDV antigen within the ciliary body and iris (a) and choroid (b). BVDV immunohistochemistry. Bars = 50 mum (a) and 20 mum (b), respectively.
case_images: CRIVEM2021-2064103.004.jpg
case_images: PMC8440096_01_CRIVEM2021-2064103.004.jpg
case_images: fig4
case_images: Scattered, intrahistiocytic immunoreactivity to BVDV antigen was observed within the ciliary body and iris (Figure 4(a)) of the left eye. Endothelial cells exhibited scattered immunoreactivity within the choroid (Figure 4(b)).