case_images: PMC4090429_01
case_images: (a) Pure tone audiogram at presentation. (b) Pure tone audiogram 2 years following PORP.
case_images: CRIOT2014-342125.001.jpg
case_images: PMC4090429_01_CRIOT2014-342125.001.jpg
case_images: fig1
case_images: A pure tone audiogram (Figure 1) showed normal hearing in the right ear, with a high frequency sensorineural loss in the left. No signs of persistence or recurrence were found, and a partial ossicular reconstruction prosthesis (PORP) was performed with good results (see Figure 1(b)).
case_images: Computer tomogram at presentation.
case_images: CRIOT2014-342125.002.jpg
case_images: PMC4090429_01_CRIOT2014-342125.002.jpg
case_images: fig2
case_images: Temporal bone computer tomography showed a right sided middle ear soft tissue mass with possible erosion of the ossicles (Figure 2).
case_images: Intraoperative findings.
case_images: CRIOT2014-342125.003.jpg
case_images: PMC4090429_01_CRIOT2014-342125.003.jpg
case_images: fig3
case_images: Intraoperatively (Figure 3), the whole middle ear was filled with the soft tissue mass apart from a small area superiorly/anteriorly.
case_images: (a) Histological finding (overview), neuroendocrine adenoma (hematoxylin-eosin stain). (b) Histological finding (magnification), neuroendocrine adenoma (hematoxylin-eosin stain). (c) Histological finding (magnification), neuroendocrine differentiation (synaptophysin stain).
case_images: CRIOT2014-342125.004.jpg
case_images: PMC4090429_01_CRIOT2014-342125.004.jpg
case_images: fig4
case_images: Pathological examination revealed a glandular and neuroendocrine tumor with areas of pleomorphic nuclei (Figures 4(a) and 4(b)). Immunohistochemically, the cells excessively expressed a marker protein for neuroendocrine cells (synaptophysin, Figure 4(c)) and partially chromogranin A.