case_images: PMC10975643_01
case_images: Computerized tomography urography scan showing a soft tissue density shadow (red arrow) in the distal end of the right ureter.
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case_images: PMC10975643_01_fonc-14-1308399-g001.jpg
case_images: f1
case_images: Urinalysis shows positive for occult blood, and computed tomography urography (CTU) scan detected a 1.2-cm-diameter tumor at the end of the right ureter ( Figure 1 ).
case_images: Hematoxylin and eosin stain reveals high-grade urothelial carcinoma in the bladder (A) and shows infiltration of urothelial carcinoma in the testis (B). Immunohistochemical illustration of GATA3+ (C) and PD-L1+ (D) tumor cells.
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case_images: PMC10975643_01_fonc-14-1308399-g002.jpg
case_images: f2
case_images: Postoperative pathological examination verified high-grade muscle-invasive UC ( Figure 2A ) with involvement of the prostate and vas deferens. Postoperative pathology suggested high-grade UC, and its histological features were similar to those observed after radical bladder operation ( Figure 2B ). Additionally, immunohistochemical staining showed positive expressions of GATA3 ( Figure 2C ) and PD-L1 ( Figure 2D ) and negative expressions of AFP, PLAP, and Oct-3/4, indicating testicular metastasis from urothelial carcinoma.
case_images: Scrotal ultrasound suggests inflammatory changes in the left epididymis and low echogenicity (red arrow) in the lower part of the left testicle.
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case_images: PMC10975643_01_fonc-14-1308399-g003.jpg
case_images: f3
case_images: Scrotal ultrasound suggests a high possibility of epididymitis ( Figure 3 ).