case_images: PMC11440967_01
case_images: (A,B) Whole-body PET/CT shows high metabolism of 18F-FDG in the third lumbar vertebral body (SUV max 19.6) (arrows) and spinous process of the fifth cervical vertebra (SUV max of 4.5) in patient 1. (C) Whole-body PET/CT shows high metabolism of 18F-FDG in the seventh cervical vertebral body, the left transverse process of the third thoracic vertebra, and the right transverse process of the fourth lumbar vertebra (SUV max 8.5) (arrows) in the patient 2. (D) Whole-body PET/CT shows high metabolism of 18F-FDG in the fourth lumbar vertebral body in patient 3. (E,F) Axial PET/CT fused images demonstrated hypermetabolic lumber vertebral body lesions in patient 1. (G,H) Axial PET/CT fused images demonstrated hypermetabolic cervical vertebra in patient 2 and lumber vertebra in patient 3. (I) The histopathology of HE staining reveals lymphocyte hyperplasia in patient 1. These myeloma cells were filled with atypical blastic cells, containing a round nucleus. (J,K,L) The immunohistochemical results show positive staining of CD138, CD38, and lambda (HE x 40) and negative staining of kappa, CD3 and CD20.
case_images: fnume-04-1446780-g001.jpg
case_images: PMC11440967_03_fnume-04-1446780-g001.jpg
case_images: F1
case_images: Given the lack of response to CIDP treatment and the presence of paraneoplastic indicators, an 18F-FDG PET/CT scan was performed, revealing intense uptake of a sclerotic lesion in the fourth lumbar vertebra (Figure 1).
case_images: PMC11440967_02
case_images: (A,B) Whole-body PET/CT shows high metabolism of 18F-FDG in the third lumbar vertebral body (SUV max 19.6) (arrows) and spinous process of the fifth cervical vertebra (SUV max of 4.5) in patient 1. (C) Whole-body PET/CT shows high metabolism of 18F-FDG in the seventh cervical vertebral body, the left transverse process of the third thoracic vertebra, and the right transverse process of the fourth lumbar vertebra (SUV max 8.5) (arrows) in the patient 2. (D) Whole-body PET/CT shows high metabolism of 18F-FDG in the fourth lumbar vertebral body in patient 3. (E,F) Axial PET/CT fused images demonstrated hypermetabolic lumber vertebral body lesions in patient 1. (G,H) Axial PET/CT fused images demonstrated hypermetabolic cervical vertebra in patient 2 and lumber vertebra in patient 3. (I) The histopathology of HE staining reveals lymphocyte hyperplasia in patient 1. These myeloma cells were filled with atypical blastic cells, containing a round nucleus. (J,K,L) The immunohistochemical results show positive staining of CD138, CD38, and lambda (HE x 40) and negative staining of kappa, CD3 and CD20.
case_images: fnume-04-1446780-g001.jpg
case_images: PMC11440967_03_fnume-04-1446780-g001.jpg
case_images: F1
case_images: Given the lack of response to CIDP treatment and the presence of paraneoplastic indicators, an 18F-FDG PET/CT scan was performed, revealing intense uptake of a sclerotic lesion in the fourth lumbar vertebra (Figure 1).
case_images: PMC11440967_03
case_images: (A,B) Whole-body PET/CT shows high metabolism of 18F-FDG in the third lumbar vertebral body (SUV max 19.6) (arrows) and spinous process of the fifth cervical vertebra (SUV max of 4.5) in patient 1. (C) Whole-body PET/CT shows high metabolism of 18F-FDG in the seventh cervical vertebral body, the left transverse process of the third thoracic vertebra, and the right transverse process of the fourth lumbar vertebra (SUV max 8.5) (arrows) in the patient 2. (D) Whole-body PET/CT shows high metabolism of 18F-FDG in the fourth lumbar vertebral body in patient 3. (E,F) Axial PET/CT fused images demonstrated hypermetabolic lumber vertebral body lesions in patient 1. (G,H) Axial PET/CT fused images demonstrated hypermetabolic cervical vertebra in patient 2 and lumber vertebra in patient 3. (I) The histopathology of HE staining reveals lymphocyte hyperplasia in patient 1. These myeloma cells were filled with atypical blastic cells, containing a round nucleus. (J,K,L) The immunohistochemical results show positive staining of CD138, CD38, and lambda (HE x 40) and negative staining of kappa, CD3 and CD20.
case_images: fnume-04-1446780-g001.jpg
case_images: PMC11440967_03_fnume-04-1446780-g001.jpg
case_images: F1
case_images: Given the lack of response to CIDP treatment and the presence of paraneoplastic indicators, an 18F-FDG PET/CT scan was performed, revealing intense uptake of a sclerotic lesion in the fourth lumbar vertebra (Figure 1).