case_images: PMC5726694_01
case_images: Clinical aspect of the histoplasmosis lesion: granular ulcer with red and
  yellow dots in the hard-soft palate
case_images: abd-92-05-s1-0107-g01.jpg
case_images: PMC5726694_01_abd-92-05-s1-0107-g01.jpg
case_images: f1
case_images: An 81-year-old male Caucasian patient was referred to our unit with a lesion on the soft palate that had appeared three months before (Figure 1).
case_images: Histopathological aspects of histoplasmosis. A:
  microphotograph showing diffuse infiltrate of epithelioid macrophages
  containing H. capsulum (arrow). Presence of
  lymphoplasmacytic inflammatory infiltrate with polymorphonuclear
  neutrophils (Hematoxylin & eosin, X400). B:
  microphotograph showing small particles of H.
  capsulatum measuring between 1 and 2microm (arrow).
  (GMS, X200)
case_images: abd-92-05-s1-0107-g02.jpg
case_images: PMC5726694_01_abd-92-05-s1-0107-g02.jpg
case_images: f2
case_images: The slides with the specimens were stained with hematoxylin-eosin (HE) and Gomori's methenamine-silver (GMS), confirming the presence of the fungus (Figure 2).
case_images: Radiograph revealed micronodules and fibroatelectatic changes, which are
  nonspecific and may be residual, associated with smoking and COPD. There
  is no evidence of active pleuropulmonary lesions
case_images: abd-92-05-s1-0107-g03.jpg
case_images: PMC5726694_01_abd-92-05-s1-0107-g03.jpg
case_images: f3
case_images: The patient was referred to assess pulmonary involvement, and there was no evidence of active pleuropulmonary lesions (Figure 3).
case_images: Clinical aspect of the lesion 30 days after starting treatment
case_images: abd-92-05-s1-0107-g04.jpg
case_images: PMC5726694_01_abd-92-05-s1-0107-g04.jpg
case_images: f4
case_images: Itraconazole 200 mg/day was prescribed for the treatment of oral histoplasmosis, with significant improvement after 30 days (Figure 4).