case_images: PMC11061499_01
case_images: (A,B) erythema based pustules appeared on the trunk and palms of both hands after the 8th dose of secukinumab. (C,D) The pustulae of the trunk and palms of both hands completely subsided after local treatment and oral acitretin. (E,F) HE pathological staining showed epidermal psoriatic hyperplasia, neutrophil abscess in the upper granulosa layer, vascular dilation in the superficial dermis, and inflammatory cell infiltration dominated by peritubular lymphocytes.
case_images: fmed-11-1364127-g001.jpg
case_images: PMC11061499_01_fmed-11-1364127-g001.jpg
case_images: fig1
case_images: After 3 months of treatment, dense pustules appeared on the erythematous bases of both his hands and feet, accompanied by a feeling of tightness, and scattered millet-sized pustules on the trunk (Figures 1A,B). Histopathology of the palm pustules indicated a diagnosis consistent with pustular psoriasis (Figures 1E,F). One month after treatment, The rashes on the patient's trunk and limbs had mostly subsided (Figures 1C,D).