case_images: PMC11789685_01
case_images: (A,B) Typical tall columnar tumor cells arranged closely and forming irregular glands of varying sizes, characteristic of colorectal villous-tubular adenoma. (C) Positive staining for CDX-2 in tumor cells. (D) Dim expression of SATB2 in the nuclei. (E) Lack of PSA expression. (F) Positive findings for CK7. (G) Positive findings for CK20. (H) The Ki-67 index is approximately 70%.
case_images: fmed-11-1494952-g001.jpg
case_images: PMC11789685_01_fmed-11-1494952-g001.jpg
case_images: F1
case_images: Immunohistochemistry was negative for PSA, NKX3.1, P63, and GATA3, but positive for CK7, CK20, beta-catenin, CDX2, and SATB2 (Figure 1). PET-CT to assess the tumor burden. MRI showed no enlarged lymph nodes, no signs of malignancy in the local prostate area post-surgery, and no abnormalities in the surrounding tissues. PET-CT revealed increased FDG metabolism in the residual prostate tissue, consistent with postoperative changes, and identified a 1.5 x 1.3 cm irregular fluorodeoxyglucose hypermetabolic nodule in the upper lobe of the right lung, suggesting metastasis (Supplementary Figure 1).