The Centriolar Theory of Differentiation Explains the Biological Meaning of the Centriolar Theory of Organismal Aging

Abstract

Centrioles, once thought to be simple structural components of the cell, have emerged as critical players in the aging process. This article reviews the existing theories linking centrioles to organismal aging, focusing on their roles in genomic stability, stem cell function, ciliary signaling, oxidative stress, and replicative Hyflick limit. Explored the evidence from model organisms, human studies, and clinical implications, highlighting the potential of centriole-targeted therapies to delay aging and prevent age-related diseases. By integrating findings from cellular biology, genetics, and clinical research, this article provides a comprehensive overview of the current understanding of centrioles in aging and outlines future directions for research and therapeutic development. The Centriolar Theory of Aging of the Organism is presented, which sees the accumulation of old, unrepairable centrioles in the organism as the main cause of the aging phenomenon. The biological meaning of this theory is explained by the Centriolar Theory of Differentiation, which links differentiation with centrioles. Thus, aging of the organism is not a separately programmed process or a separately stochastic process - both of these processes contribute. Aging of the organism is the result of the accumulation of old, unrepairable centrioles (stochastically accumulating defects) by the organism due to the implementation of differentiation programs (in the processes of development and then self-restoration).

Keywords: centrioles, aging, genomic instability, stem cell dysfunction, senescence, oxidative stress