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          "tag": "attribute"
        }
      ],
      "common name": [
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          "ontologyTerms": [
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        }
      ],
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        {
          "text": "Protocols: The cells were generated by infecting cells with 2nd generation lentiviruses. The genes are under Tet-on control. 2d and 4d indicates either doxycycline induction for 2 or 4 days. Het1A, Het1A-HNF4A and Het1A-GATA6 cells were cultured in DMEM (+10% FBS and 1% PenStrep) with 100ng/mL doxycycline for 2 or 4 days. Cells were trypsinised and counted. 50000 cells were taken forward for Tn5 reaction. 50000 cells were lysed in ATAC lysis buffer and Tn5 reactions were performed as described in Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. 2013. Jason D. Buenrostro, Paul G. Giresi, Lisa C. Zaba, Howard Y. Chang and William J. Greenleaf. doi:10.1038/nmeth.2688 Libraries were constructed by amplifying transposed DNA with Illumina Nextera adapters."
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          "text": "normal",
          "ontologyTerms": [
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          ],
          "tag": "attribute"
        }
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          "text": "GATA6-tet-on",
          "tag": "attribute"
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      "organism": [
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          "text": "Homo sapiens",
          "ontologyTerms": [
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          ]
        },
        {
          "text": "Homo sapiens",
          "ontologyTerms": [
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          ],
          "tag": "attribute"
        }
      ],
      "organism part": [
        {
          "text": "esophagus",
          "ontologyTerms": [
            "http://purl.obolibrary.org/obo/UBERON_0001043"
          ],
          "tag": "attribute"
        }
      ],
      "phenotype": [
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          "text": "doxycyclin mediated overexpression of GATA6",
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        }
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        {
          "text": "Homo sapiens",
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      "title": [
        {
          "text": "Het1A-GATA6_4d_rep1"
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      "cell line": [
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          "text": "Protocols: ATAC was performed following the protocol of Buenrostro et al. Briefly, 50,000 L3.6pl cells were trypsinized and washed twice with cold PBS. Then cells were re-suspended in lysis buffer (10mM Tris-HCl pH 7.5, 10mM NaCl, 3mM MgCl2, 0.1% IGEPAL CA-630) and incubated for 15 minutes at a rotating wheel at 4ºC followed by centrifugation and in re-suspended in 50 µl of transposition mix composed of 2.5µl of TDE1 (Nextera Tn5 Transposase), 25 µl TD (2x reaction buffer) in nuclease free water (Nextera DNA Library Prep Kit, FC-121-1030, Illumina). Then it was incubated at 37 degrees for 30 minutes. MinElute PCR Purification kit (Qiagen) was used for DNA extraction following the instructions of the manufacturer. ATAC libraries were made using the Nextera DNA Library Prep Kit according to Buenrostro et al. The libraries were amplified for 15 cycles in total of: 98ºC for 10 seconds, 63ºC for 30 seconds, and 72ºC for 60 seconds."
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          "tag": "attribute"
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      "organism part": [
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          "text": "pancreas",
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      "scientific_name": [
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          "text": "Homo sapiens",
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      "title": [
        {
          "text": "L3.6pl_ATAC_C2"
        }
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    "create": "2019-03-30T05:21:04.632Z",
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      "broker name": [
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      "cell type": [
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      "description": [
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      "individual": [
        {
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          "tag": "attribute"
        }
      ],
      "organism": [
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        },
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          "tag": "attribute"
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      "organism part": [
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          "tag": "attribute"
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      "post analysis well quality": [
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          "tag": "attribute"
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      ],
      "title": [
        {
          "text": "human_skin_fibr_229"
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    "name": "KLF1-24_I16-1573-04-m4",
    "accession": "SAMEA5424632",
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    "release": "2020-01-06T04:04:25Z",
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      "description": [
        {
          "text": "KLF1 haploinsufficiency m4 proliferating erythroblasts ATAC-seq fastq files"
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          "ontologyTerms": [
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      "organism": [
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          "text": "Homo sapiens",
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          "tag": "attribute"
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      "title": [
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    "accession": "SAMEA5547874",
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      "cell type": [
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        {
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      ],
      "disease": [
        {
          "text": "clear cell renal carcinoma",
          "ontologyTerms": [
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          "tag": "attribute"
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      ],
      "genotype": [
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          "text": "doxycycline inducible PAX8 knockdown",
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          "text": "Homo sapiens",
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          "text": "Homo sapiens",
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      ],
      "title": [
        {
          "text": "Caki-1_3"
        }
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    "name": "E-MTAB-8676:rs411 edited 3 (SPI1 -/-)",
    "accession": "SAMEA6479266",
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          "text": "2020-06-05T04:03:52Z"
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          "text": "2020-01-16T11:41:59Z"
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          "text": "RS4;11",
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          "text": "lymphoblast",
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          "text": "Homo sapiens",
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      "title": [
        {
          "text": "rs411 edited 3 (SPI1 -/-)"
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      "cell_type": [
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          "text": "Protocols: OE19 cells were treated with DMSO for 1 day or 500 nM lapatinib for 1, 7 or 35 days and then trypsinised and collected Omni ATAC-seq protocol: Corces, M., Trevino, A., Hamilton, E. et al. An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Nat Methods 14, 959–962 (2017). https://doi.org/10.1038/nmeth.4396 Omni ATAC-seq protocol: Corces, M., Trevino, A., Hamilton, E. et al. An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. Nat Methods 14, 959–962 (2017). https://doi.org/10.1038/nmeth.4396"
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      ],
      "disease": [
        {
          "text": "esophageal adenocarcinoma",
          "tag": "attribute"
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      ],
      "genotype": [
        {
          "text": "wild type genotype",
          "tag": "attribute"
        }
      ],
      "isolate": [
        {
          "text": "not applicable",
          "tag": "attribute"
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      "organism": [
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          "text": "Homo sapiens",
          "ontologyTerms": [
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        },
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          "text": "Homo sapiens",
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      "organism part": [
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          "text": "esophagogastric junction",
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    "name": "E-MTAB-10444:Th1 1h L",
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      "individual": [
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      "stimulus": [
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          "text": "Anti-CD3/CD28, IL2 and IL12",
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      "title": [
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          "text": "Th1 1h L"
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