Supported by the project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, ID Project No. LX22NPO5104) - Funded by the European Union—Next Generation EU.
", "type": { "id": "notes", "title": { "de": "Anmerkungen", "en": "Notes" } } } ], "creators": [ { "affiliations": [ { "name": "Hosp Univ Puerta Hierro, Serv Cardiol, Inst Invest Sanitaria Puerta Hierro Segovia de Ara, Madrid, Spain" } ], "person_or_org": { "family_name": "Restrepo-Cordoba", "given_name": "Maria Alejandra", "name": "Restrepo-Cordoba, Maria Alejandra", "type": "personal" } }, { "affiliations": [ { "name": "Natl Inst Cardiol, Unit Screening Studies Inherited Cardiovasc Dis, Warsaw, Poland" } ], "person_or_org": { "family_name": "Chmielewski", "given_name": "Przemyslaw", "name": "Chmielewski, Przemyslaw", "type": "personal" } }, { "affiliations": [ { "name": "Natl Inst Cardiol, Dept Med Biol, Warsaw, Poland" } ], "person_or_org": { "family_name": "Truszkowska", "given_name": "Grazyna", "name": "Truszkowska, Grazyna", "type": "personal" } }, { "affiliations": [ { "name": "Hosp Univ Virgen Rocio, Serv Cardiol, Unidad Imagen & Cardiopatias Familiares, Seville, Spain" } ], "person_or_org": { "family_name": "Pena-Pena", "given_name": "Maria Luisa", "name": "Pena-Pena, Maria Luisa", "type": "personal" } }, { "affiliations": [ { "name": "Institut klinicke a experimentalni mediciny" } ], "person_or_org": { "family_name": "Kubanek", "given_name": "Milos", "identifiers": [ { "identifier": "0000-0003-1864-0949", "scheme": "orcid" } ], "name": "Kubanek, Milos", "type": "personal" } }, { "affiliations": [ { "name": "Institut klinicke a experimentalni mediciny" } ], "person_or_org": { "family_name": "Krebsova", "given_name": "Alice", "identifiers": [ { "identifier": "0000-0001-8319-1460", "scheme": "orcid" } ], "name": "Krebsova, Alice", "type": "personal" } }, { "affiliations": [ { "name": "UCL, Inst Cardiovasc Sci, London, England" } ], "person_or_org": { "family_name": "Lopes", "given_name": "Luis R", "name": "Lopes, Luis R", "type": "personal" } }, { "affiliations": [ { "name": "Guys & St Thomas NHS Fdn Trust, London, England" } ], "person_or_org": { "family_name": "Garcia-Ropero", "given_name": "Alvaro", "name": "Garcia-Ropero, Alvaro", "type": "personal" } }, { "affiliations": [ { "name": "Azienda Sanit Univ Giuliano Isontina ASUGI, Trieste, Italy" } ], "person_or_org": { "family_name": "Merlo", "given_name": "Marco", "name": "Merlo, Marco", "type": "personal" } }, { "affiliations": [ { "name": "Azienda Sanit Univ Giuliano Isontina ASUGI, Trieste, Italy" } ], "person_or_org": { "family_name": "Paldino", "given_name": "Alessia", "name": "Paldino, Alessia", "type": "personal" } }, { "affiliations": [ { "name": "Royal Melbourne Hosp, Dept Cardiol, Melbourne, Vic, Australia" } ], "person_or_org": { "family_name": "Peters", "given_name": "Stacey", "name": "Peters, Stacey", "type": "personal" } }, { "affiliations": [ { "name": "UMF Carol Davila, Emergency Inst Cardiovasc Dis Prof Dr CC Iliescu, Ctr Rare Genet Cardiovasc Dis, Bucharest, Romania" } ], "person_or_org": { "family_name": "Jurcut", "given_name": "Ruxandra", "name": "Jurcut, Ruxandra", "type": "personal" } }, { "affiliations": [ { "name": "Complexo Hosp Univ A Coruna, Serv Cardiol, Unidad Cardiopatias Familiares, Inst Invest Biomed A Coruna INIB, La Coruna, Spain" } ], "person_or_org": { "family_name": "Barriales-Villa", "given_name": "Roberto", "name": "Barriales-Villa, Roberto", "type": "personal" } }, { "affiliations": [ { "name": "Drone Hopper Co, Madrid, Spain" } ], "person_or_org": { "family_name": "Zorio", "given_name": "Esther", "name": "Zorio, Esther", "type": "personal" } }, { "affiliations": [ { "name": "Maastricht Univ, Med Ctr, Dept Cardiol, Maastricht, Netherlands" } ], "person_or_org": { "family_name": "Hazebroek", "given_name": "Mark", "name": "Hazebroek, Mark", "type": "personal" } }, { "affiliations": [ { "name": "Skejby Univ Hosp, Dept Cardiol, Hobrovej R Bb, Denmark" } ], "person_or_org": { "family_name": "Mogensen", "given_name": "Jens", "name": "Mogensen, Jens", "type": "personal" } }, { "affiliations": [ { "name": "Univ Francisco de Vitoria UFV, Madrid, Spain" } ], "person_or_org": { "family_name": "Garcia-Pavia", "given_name": "Pablo", "name": "Garcia-Pavia, Pablo", "type": "personal" } } ], "description": "Introduction and objectives: Limited information is available on the safety of pregnancy in patients with genetic dilated cardiomyopathy (DCM) and in carriers of DCM-causing genetic variants without the DCM phenotype. We assessed cardiac, obstetric, and fetal or neonatal outcomes in this group of patients. Methods: We studied 48 women carrying pathogenic or likely pathogenic DCM-associated variants (30 with DCM and 18 without DCM) who had 83 pregnancies. Adverse cardiac events were defined as heart failure (HF), sustained ventricular tachycardia, ventricular assist device implantation, heart transplant, and/or maternal cardiac death during pregnancy, or labor and delivery, and up to the sixth postpartum month. Results: A total of 15 patients, all with DCM (31% of the total cohort and 50% of women with DCM) experienced adverse cardiac events. Obstetric and fetal or neonatal complications were observed in 14% of pregnancies (10 in DCM patients and 2 in genetic carriers). We analyzed the 30 women who had been evaluated before their first pregnancy (12 with overt DCM and 18 without the phenotype). Five of the 12 (42%) women with DCM had adverse cardiac events despite showing NYHA class I or II before pregnancy. Most of these women had a history of cardiac events before pregnancy (80%). Among the 18 women without phenotype, 3 (17%) developed DCM toward the end of pregnancy . Conclusions: Cardiac complications during pregnancy and postpartum were common in patients with genetic DCM and were primarily related to HF. Despite apparently good tolerance of pregnancy in unaffected genetic carriers, pregnancy may act as a trigger for DCM onset in a subset of these women. (c) 2024 Sociedad Espanola de Cardiolog & imath;a. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).", "languages": [ { "id": "eng", "title": { "en": "English" } } ], "publication_date": "2025-01-01", "publisher": "Zenodo", "related_identifiers": [ { "identifier": "38641168", "relation_type": { "id": "hasmetadata", "title": { "de": "Hat Metadaten in", "en": "Has metadata" } }, "scheme": "pmid" }, { "identifier": "0300-8932", "relation_type": { "id": "ispartof", "title": { "de": "Ist Teil von", "en": "Is part of" } }, "scheme": "issn" }, { "identifier": "1579-2242", "relation_type": { "id": "ispartof", "title": { "de": "Ist Teil von", "en": "Is part of" } }, "scheme": "issn" }, { "identifier": "10.1016/j.rec.2024.04.002", "relation_type": { "id": "references", "title": { "de": "Referenziert", "en": "References" } }, "scheme": "doi" } ], "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "Dilated cardiomyopathy" }, { "subject": "Pregnancy" }, { "subject": "Heart failure" }, { "subject": "Mutation" } ], "title": "Pregnancy in women with dilated cardiomyopathy genetic variants" }, "parent": { "access": { "owned_by": { "user": "470919" }, "settings": { "accept_conditions_text": null, "allow_guest_requests": false, "allow_user_requests": false, "secret_link_expiration": 0 } }, "communities": { "default": "39f08cf6-4606-4e08-a965-264dae4dab6a", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_submission_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2023-01-11T06:18:56.680371+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "39f08cf6-4606-4e08-a965-264dae4dab6a", "links": {}, "metadata": { "curation_policy": "", "description": "The results of publications and research carried out at IKEM or in which IKEM participates", "page": "", "title": "Institute for Clinical and Experimental Medicine" }, "revision_id": 0, "slug": "ikem", "updated": "2023-01-11T06:19:04.712140+00:00" }, { "access": { "member_policy": "open", "members_visibility": "public", "record_submission_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2023-01-11T06:23:48.723821+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "cb87607a-f6cd-4c8f-bd77-4fa4b81d2c53", "links": {}, "metadata": { "curation_policy": "", "page": "Programme EXCELES, Project No. LX22NPO5104) funded by
\r\nthe European Union - Next Generation EU