Paediatric patients with congenital heart disease often undergo cardiac catheterisation procedures and are exposed to considerable ionising radiation early in life. This study aimed to develop a method for estimating the dose area product (PKA) from paediatric cardiac catheterisation procedures (1975–1989) at a national centre for paediatric cardiology and to evaluate trends in PKA and exposure parameters until 2021. Data from 2200 catheterisation procedures on 1685 patients (1975–1989) and 4184 procedures on 2139 patients (2000–2021) under 18 years of age were retrospectively collected. PKA values were missing for 1975–1989 but available from 2000 onward. The missing PKA was estimated from air kerma and beam area, based on exposure records and input from clinicians working at that time. PKA trends were analysed over time and age. There was a 71% reduction in median PKA from the period 1975–1989 (median 6.63 Gy cm2) to 2011–2021 (1.91 Gy cm2). The PKA increases significantly (p = 0.0001) with patient age, which was associated with body weight. Approximately 80% of the total PKA was from cine acquisition in 1975–1989, while 20% was from fluoroscopy. The PKA estimate during 1975–1989 was considerably impacted by the assumptions of missing parameters such as tube filtration, focus-to-heart distance, beam area, and number of cine series. The decreasing trend in PKA values was attributed to advancements in both technologies and clinical practices. The high contribution of cine acquisition to the total dose during 1975–1989 was due to factors such as a high frame rate, multiple acquisitions, and high tube current. The estimated PKA values for the period 1975–1989 are of importance for the dose reconstruction and risk assessments in the EU epidemiology project Health Effects of Cardiac Fluoroscopy and Modern Radiotherapy in Pediatrics(HARMONIC).
", "funding": [ { "award": { "acronym": "HARMONIC", "id": "00k4n6c32::847707", "identifiers": [ { "identifier": "https://cordis.europa.eu/projects/847707", "scheme": "url" } ], "number": "847707", "program": "H2020-Euratom", "title": { "en": "Health effects of cArdiac fluoRoscopy and MOderN radIotherapy in paediatriCs" } }, "funder": { "id": "00k4n6c32", "name": "European Commission" } } ], "publication_date": "2024-12-02", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "congenital heard disease" }, { "subject": "cardiac catheterisation" }, { "id": "mesh:D006328", "scheme": "MeSH", "subject": "Cardiac Catheterization" }, { "subject": "dose area product" } ], "title": "Doses from ionizing radiation in pediatric cardiac catheterizations in Norway 1975\u2013 2021" }, "parent": { "access": { "owned_by": { "user": "147795" }, "settings": { "accept_conditions_text": null, "allow_guest_requests": false, "allow_user_requests": false, "secret_link_expiration": 0 } }, "communities": { "default": "ff009f68-0863-4e46-b957-68a67a540e84", "entries": [ { "access": { "member_policy": "open", "members_visibility": "restricted", "record_submission_policy": "open", "review_policy": "closed", "visibility": "public" }, "children": { "allow": true }, "created": "2022-11-23T15:53:29.436323+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "f0a8b890-f97a-4eb2-9eac-8b8a712d3a6c", "links": {}, "metadata": { "curation_policy": "The EU Open Research Repository serves as a repository for research outputs (data, software, posters, presentations, publications, etc) which have been funded under an EU research funding programme such as Horizon Europe, Euratom or earlier Framework Programmes.
\nThe community is managed by CERN on behalf of the European Commission.
\nZenodo’s general policies and Terms of Use apply to all content.
\nThe EU Open Research Repository accepts all digital research objects which is a research output stemming from one of EU’s research and innovation funding programmes. The funding programmes currently include:
\nHorizon Europe (including ERC, MSCA), earlier Framework Programmes (eg Horizon 2020) as well as Euratom.
\nIn line with the principle as open as possible, as closed as necessary both public and restricted content is accepted. See note on how Zenodo handles restricted content.
\nEU programme beneficiaries are eligible to submit content to the community. The community supports three types of content submissions:
\nSubmission via an EU Project Community (through user interface or programmatic APIs).
\nSubmission directly to the EU Open Research Repository.
\nAutomated harvesting from existing Zenodo content.
\nA representative of an EU project may request an EU Project Community and invite other project participants as members of the community. The project community is linked to one or more European Commission grants. All records in the project community are automatically integrated into the EU Open Research Repository immediately upon acceptance into the project community.
\nAny user may submit a record directly to the EU Open Research Repository. The submission will be moderated by Zenodo staff for compliance with the minimal required metadata requirements and its correctness.
\nRecords found among Zenodo’s existing content will on a regular basis automatically be integrated if they are found to comply with the requirements. The submissions through this method are integrated into the EU Open Research Repository with delay in a fully automated way.
\nRecords in the EU Open Research Repository are required to comply with the following minimal metadata requirements:
\nVisibility: Both public and restricted (with or without embargo and/or access request)
\nResource types: All resource types.
\nLicenses: Public and embargoed records MUST specify a license. The chosen license SHOULD be compliant with the Horizon Europe open science requirements (see Open Science in Horizon Europe)
\nFunding information: Records MUST specify at least one grant from the European Commission.
\nCreators: Creators SHOULD be identified with a persistent identifier (e.g. ORCID, GND, …), and affiliations SHOULD be identified with a persistent identifier (e.g. ROR, ISNI, …)
\nSubjects: Records SHOULD specify one or more fields of science from the European Science Vocabulary.
\nThese metadata requirements comes from the related open science requirements in Horizon Europe which are detailed in each project's grant agreement.
\nAll submissions undergo automated curation checks for compliance with the policy. Submissions through project communities are in addition reviewed by the project community. Submission directly to the EU Open Research Repository is in addiotn reviewed by Zenodo staff.
\nCommunity curators may at any point edit metadata of the records in the community without notice through human or automated processing. The curators may at their sole discretion remove records from the community that are deemed not to comply with the content and curation policy or which are deemed of insufficient quality.
\nThe content and curation policy is subject to change by the community owner at any time and without notice, other than through updating this page.
", "description": "Open repository for EU-funded research outputs from Horizon Europe, Euratom, and earlier Framework Programmes.", "funding": [ { "funder": { "id": "00k4n6c32" } } ], "organizations": [ { "id": "00k4n6c32" } ], "page": "The EU Open Research Repository is a Zenodo-community dedicated to fostering open science and enhancing the visibility and accessibility of research outputs funded by the European Union. The community is managed by CERN on behalf of the European Commission.
\nThe mission of the repository is to support the implementation of the EU's open science policy, providing a trusted and comprehensive space for researchers to share their research outputs such as data, software, reports, presentations, posters and more. The EU Open Research Repository simplifies the process of complying with open science requirements, ensuring that research outputs from Horizon Europe, Euratom, and earlier Framework Programmes are freely accessible, thereby accelerating scientific discovery and innovation.
\nThe EU Open Research Repository serves as a complementary platform to the Open Research Europe (ORE) publishing platform. Open Research Europe focuses on providing a publishing venue for peer-reviewed articles, ensuring that research meets rigorous academic standards. The EU Open Research Repository provides a space for all the other research outputs including data sets, software, posters, and presentations that are out of scope for ORE. This holistic approach enables researchers to not only publish their findings but also share the underlying data and materials that support their work, fostering transparency and reproducibility in the scientific process.
\nThe EU Open Research Repository is funded by the European Union under grant agreement no. 101256740 (HORIZON-ZEN Plus). For more information about the project see https://about.zenodo.org/projects/horizon-zen/.
", "title": "EU Open Research Repository", "type": { "id": "organization" }, "website": "https://research-and-innovation.ec.europa.eu" }, "revision_id": 24, "slug": "eu", "theme": { "brand": "horizon", "enabled": true, "style": { "font": { "family": "Arial, sans-serif", "size": "16px", "weight": 600 }, "mainHeaderBackgroundColor": "#FFFFFF", "primaryColor": "#004494", "primaryTextColor": "#FFFFFF", "secondaryColor": "#FFD617", "secondaryTextColor": "#000000", "tertiaryColor": "#e3eefd", "tertiaryTextColor": "#1c5694" } }, "updated": "2026-03-31T12:29:43.596724+00:00" }, { "access": { "member_policy": "open", "members_visibility": "public", "record_submission_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2021-04-12T09:09:30.687561+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "ff009f68-0863-4e46-b957-68a67a540e84", "links": {}, "metadata": { "curation_policy": "", "funding": [ { "award": { "id": "00k4n6c32::847707" }, "funder": { "id": "00k4n6c32" } } ], "page": "The use of ionising radiation (IR) with advanced technology in medicine represents a tremendous benefit for the diagnosis and treatment of pathologies in paediatric populations. While benefits to the patient largely outweigh the risk, the late effects of exposure to IR are particularly important to understand in populations of young patients who nowadays survive the disease for decades; the evidence to-date suggesting that children are more sensitive to the carcinogenic effects of ionizing radiation than adults.
\r\nHARMONIC aims at complementing recent studies on paediatric CT examinations, to improve understanding of the health effects of exposure to medical IR in children, specifically cancer patients treated with modern radiotherapy techniques, and cardiac patients treated with X-ray guided imaging procedures.
\r\nThe project builds on a multi-disciplinary collaboration to provide the medical and scientific communities with instruments to investigate cancer and non-cancer outcomes (neuro & cardiovascular and endocrine system effects) in these two European paediatric cohorts and evaluate Quality of Life (QoL) and social impacts, with potential for advanced patient-specific dose reconstruction and mechanistic investigations.
The HARMONIC project (Health effects of cArdiac fluoRoscopy and MOderN radIotherapy in paediatriCs) has received funding from the Euratom research and training programme 2014-2018 under grant agreement No 847707
", "title": "HARMONIC Project - Health effects of cArdiac fluoRoscopy and MOderN radIotherapy in paediatriCs" }, "parent": { "access": { "member_policy": "open", "members_visibility": "restricted", "record_submission_policy": "open", "review_policy": "closed", "visibility": "public" }, "children": { "allow": true }, "created": "2022-11-23T15:53:29.436323+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "f0a8b890-f97a-4eb2-9eac-8b8a712d3a6c", "links": {}, "metadata": { "curation_policy": "The EU Open Research Repository serves as a repository for research outputs (data, software, posters, presentations, publications, etc) which have been funded under an EU research funding programme such as Horizon Europe, Euratom or earlier Framework Programmes.
\nThe community is managed by CERN on behalf of the European Commission.
\nZenodo’s general policies and Terms of Use apply to all content.
\nThe EU Open Research Repository accepts all digital research objects which is a research output stemming from one of EU’s research and innovation funding programmes. The funding programmes currently include:
\nHorizon Europe (including ERC, MSCA), earlier Framework Programmes (eg Horizon 2020) as well as Euratom.
\nIn line with the principle as open as possible, as closed as necessary both public and restricted content is accepted. See note on how Zenodo handles restricted content.
\nEU programme beneficiaries are eligible to submit content to the community. The community supports three types of content submissions:
\nSubmission via an EU Project Community (through user interface or programmatic APIs).
\nSubmission directly to the EU Open Research Repository.
\nAutomated harvesting from existing Zenodo content.
\nA representative of an EU project may request an EU Project Community and invite other project participants as members of the community. The project community is linked to one or more European Commission grants. All records in the project community are automatically integrated into the EU Open Research Repository immediately upon acceptance into the project community.
\nAny user may submit a record directly to the EU Open Research Repository. The submission will be moderated by Zenodo staff for compliance with the minimal required metadata requirements and its correctness.
\nRecords found among Zenodo’s existing content will on a regular basis automatically be integrated if they are found to comply with the requirements. The submissions through this method are integrated into the EU Open Research Repository with delay in a fully automated way.
\nRecords in the EU Open Research Repository are required to comply with the following minimal metadata requirements:
\nVisibility: Both public and restricted (with or without embargo and/or access request)
\nResource types: All resource types.
\nLicenses: Public and embargoed records MUST specify a license. The chosen license SHOULD be compliant with the Horizon Europe open science requirements (see Open Science in Horizon Europe)
\nFunding information: Records MUST specify at least one grant from the European Commission.
\nCreators: Creators SHOULD be identified with a persistent identifier (e.g. ORCID, GND, …), and affiliations SHOULD be identified with a persistent identifier (e.g. ROR, ISNI, …)
\nSubjects: Records SHOULD specify one or more fields of science from the European Science Vocabulary.
\nThese metadata requirements comes from the related open science requirements in Horizon Europe which are detailed in each project's grant agreement.
\nAll submissions undergo automated curation checks for compliance with the policy. Submissions through project communities are in addition reviewed by the project community. Submission directly to the EU Open Research Repository is in addiotn reviewed by Zenodo staff.
\nCommunity curators may at any point edit metadata of the records in the community without notice through human or automated processing. The curators may at their sole discretion remove records from the community that are deemed not to comply with the content and curation policy or which are deemed of insufficient quality.
\nThe content and curation policy is subject to change by the community owner at any time and without notice, other than through updating this page.
", "description": "Open repository for EU-funded research outputs from Horizon Europe, Euratom, and earlier Framework Programmes.", "funding": [ { "funder": { "id": "00k4n6c32" } } ], "organizations": [ { "id": "00k4n6c32" } ], "page": "The EU Open Research Repository is a Zenodo-community dedicated to fostering open science and enhancing the visibility and accessibility of research outputs funded by the European Union. The community is managed by CERN on behalf of the European Commission.
\nThe mission of the repository is to support the implementation of the EU's open science policy, providing a trusted and comprehensive space for researchers to share their research outputs such as data, software, reports, presentations, posters and more. The EU Open Research Repository simplifies the process of complying with open science requirements, ensuring that research outputs from Horizon Europe, Euratom, and earlier Framework Programmes are freely accessible, thereby accelerating scientific discovery and innovation.
\nThe EU Open Research Repository serves as a complementary platform to the Open Research Europe (ORE) publishing platform. Open Research Europe focuses on providing a publishing venue for peer-reviewed articles, ensuring that research meets rigorous academic standards. The EU Open Research Repository provides a space for all the other research outputs including data sets, software, posters, and presentations that are out of scope for ORE. This holistic approach enables researchers to not only publish their findings but also share the underlying data and materials that support their work, fostering transparency and reproducibility in the scientific process.
\nThe EU Open Research Repository is funded by the European Union under grant agreement no. 101256740 (HORIZON-ZEN Plus). For more information about the project see https://about.zenodo.org/projects/horizon-zen/.
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