content: Transhumanism is pretty well the polar opposite of the Butlerian Jihad.  Dune is science fiction, but it doesn't glorify technology. It mostly shows how it can easily be(and very often is) misused, used for evil purposes, or shouldn't be fully relied on, as far as technology is concerned. Dune is much more about people than it is about technology. The Butlerian Jihad was humanity's revolt against everything you're talking about. Something tells me you haven't read the book.