Why Quercetin and Zinc Ought Be Your Go-To Supplements To Prevent Coronavirus Spike S-protein binding Quercetin actually works in 2 ways against coronavirus.  As a zinc carrier, and also an entry inhibitor, according to the study that used IBM SUMMIT supercomputer to find the substances that bind to the spike S-protein of the virus inhibiting interaction with ACE2 receptors on cells, which coronavirus uniquely targets Early research on existing drug compounds via supercomputing could combat coronavirus They found the following natural substances: in addition to Quercetin Quercetin, Luteolin, Eriodictyol, and Coclaurine // Yerba Santa and Sacred Lotus Zinc Ionophore I wish they'd start talking about Quercetin, EGCG and Zinc.  These work in exactly the same way as Hydroxychloroquine--they are zinc ionophores, carriers of zinc into the cytoplasm of cells to inhibit the rdrp enzyme the virus uses to replicate itself.  Here this is explained in detail with NIH citations regarding quercetin How Zinc ionophores (like Hydroxy|chloroquine, Quercetin) Inhibit the The Human Coronavirus from Replicating (and fight Cancer cells) Numerous NIH citations in the link above