Cancer  Cannabidiol as potential anticancer drug -- "Collectively, the non-psychoactive plant-derived cannabinoid CBD exhibits pro-apoptotic and anti-proliferative actions in different types of tumours and may also exert anti-migratory, anti-invasive, anti-metastatic and perhaps anti-angiogenic properties. On the basis of these results, evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread." The combination of cannabidiol and Δ9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model. -- "High-grade glioma is one of the most aggressive cancers in adult humans and long-term survival rates are very low as standard treatments for glioma remain largely unsuccessful. Cannabinoids have been shown to specifically inhibit glioma growth as well as neutralize oncogenic processes such as angiogenesis" -- "Holy sh_t." Cannabidiol as potential anticancer drug. The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2. --"...we investigated the effects of CBD and BORT in CD138+TRPV2- MM cells and in MM cell lines transfected with TRPV2 (CD138+TRPV2+). These results showed that CBD by itself or in synergy with BORT strongly inhibited growth, arrested cell cycle progression and induced MM cells death by regulating the ERK, AKT and NF-κB pathways with major effects in TRPV2+ cells." Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol. -- "CBD BDS attenuates colon carcinogenesis and inhibits colorectal cancer cell proliferation via CB1 and CB2 receptor activation. The results may have some clinical relevance for the use of Cannabis-based medicines in cancer patients."  Anxiety, anti-psychotic / psychiatric activity  A systematic review of the antipsychotic properties of cannabidiol in humans. -- "The first small-scale clinical studies with CBD treatment of patients with psychotic symptoms further confirm the potential of CBD as an effective, safe and well-tolerated antipsychotic compound, although large randomised clinical trials will be needed before this novel therapy can be introduced into clinical practice." A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation. --"These results support the idea that CBD may be a future therapeutic option in psychosis, in general and in schizophrenia, in particular." Antipsychotic-like effects of cannabidiol and rimonabant: systematic review of animal and human studies. -- "The results predominantly confirm the hypothesis of an antipsychotic activity of both cannabinoids. In comparison, cannabidiol appears to be superior to rimonabant with a pharmacological profile similar to atypical antipsychotic drugs." Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa. -- "[tests]...suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed." Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. --" It was verified that CBD blocks the anxiety provoked by delta 9-THC, however this effect also extended to marihuana-like effects and to other subjective alterations induced by delta 9-THC."  -- This is why overly paranoid people prefer Indica variety for their higher proprotion of CBD to THC, something that's been known literally forever, but now verified via NIH. Medical use of cannabis. Cannabidiol: a new light for schizophrenia? -- Behavioural and neurochemical models suggest that CBD has a pharmacological profile similar to that of atypical anti-psychotic drugs and a clinical trial reported that this cannabinoid is a well-tolerated alternative treatment for schizophrenia. Decreased glial reactivity could be involved in the antipsychotic-like effect of cannabidiol. -- "Both the behavioral disruptions and the changes in expression of glial markers induced by MK-801 treatment were attenuated by repeated treatment with CBD or clozapine. These data reinforces the proposal that CBD may induce antipsychotic-like effects."  Inflammation, Immune system, Neuroprotective, Arthitis  Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants -- "The nonpsychoactive marijuana constituent cannabidiol was found to prevent both glutamate neurotoxicity and ROS-induced cell death." Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes. -- "Collectively, our findings suggest that, due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne vulgaris."  Epilepsy, neurological disorders  Molecular Targets of Cannabidiol in Neurological Disorders. Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. -- "Some suspect an existence of synergy or "entourage effect" between CBD and THC." (you need the whole herb) The scientific data support the role of the endocannabinoid system in seizure generation, maintenance, and control in animal models of epilepsy. There are clear data for the negative effects of cannabis on the developing and mature brain though these effects appear to be relatively mild in most cases." Cannabis, cannabidiol, and epilepsy--from receptors to clinical response. --  Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? -- "The neuroprotective potential of CBD, based on the combination of its anti-inflammatory and anti-oxidant properties, is of particular interest and is presently under intense preclinical research in numerous neurodegenerative disorders." Cannabidiol: a promising drug for neurodegenerative disorders? Cannabidiol: Promise and Pitfalls -- "At this time, there does seem to be a growing body of basic pharmacologic data suggesting there may be a role for CBD, especially in the treatment of refractory epilepsy."  Going on to say it needs better clinical trials. Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome. --  Eighty-five percent (85%) of all parents reported a reduction in seizure frequency, and 14% reported complete seizure freedom Chronic administration of cannabidiol to healthy volunteers and epileptic patients. -- "All patients and volunteers tolerated CBD very well and no signs of toxicity or serious side effects were detected on examination... The potential use of CBD as an antiepileptic drug and its possible potentiating effect on other antiepileptic drugs are discussed." Hypnotic and antiepileptic effects of cannabidiol. -- "Fifteen patients suffering from secondary generalized epilepsy refractory to known antiepileptic drugs received either 200 to 300 mg cannabidiol daily or placebo for as long as 4.5 months. Seven out of the eight epileptics receiving cannabidiol had improvement of their disease state, whereas only one placebo patient improved." Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. -- "However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives" --- Again, non-psychotropic mention Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial. -- "Our findings point to a possible effect of CBD in improving quality of life measures in PD patients with no psychiatric comorbidities;" Open label evaluation of cannabidiol in dystonic movement disorders. -- "CBD appears to have antidystonic and Parkinsonism-aggravating effects in humans."