Not if you manage diet and exercise... oh, wait, lazy fats we're talking about here. What was I thinking. (Also managing hormone replacement for humans, but let's be real, that's not a magic bullet and I've seen way the fuck too many transfats blame hormones for their lard. Never mind the transfemayos insist it's lower testosterone and higher oestrogen making them gain weight... but the transmayos insist that going on testosterone made them pack on the pounds...)