Calorie measurements of food already take the biochemistry into account, and they aren't simply burning food and measuring the heat produced. Food calories are an excellent way to predict body weight changes.  CICO (calories in, calories out) is a shitty way to plan weight loss.  MOTHERFUCKING BULLSHIT Seriously straight up bullshit. You should be ashamed of yourself. Tell that to the millions who've lost weight and kept it off via CICO. In fact, CICO is the only thing that does work.  Please, don't promote fat logic. Thank you.  You must be fat to be this delusional, hypocritical, and unknowingly ironic.