I've been playing a lot of the new Hitman and this would be a great handicap to have. It would make everything more challenging and hilarious. Running up stairs would make you out of breath, vaulting out windows would be suicide, climbing up the side of buildings would be slow as fuck, and any disguise you steal involves a big ripping noise. Your character would also have a eating disorder so poisoning food would become even more dangerous because your character might eat or drink it. Sneaking would be a hilarious failure on it's own and all the NPCs will shitlord you even when you're killing them.