Had to look up dnp ... holy fucking shit that stuff is ridiculous. For anyone curious:  The factor that limits ever-increasing doses of DNP is not a lack of ATP energy production, but rather an excessive rise in body temperature due to the heat produced during uncoupling. Accordingly, DNP overdose will cause fatal hyperthermia, with body temperature rising to as high as 44 °C (111 °F) shortly before death. In light of this, when it was used clinically, the dose was slowly titrated according to personal tolerance, which varies greatly.[10] Case reports have shown that an acute administration of 20–50 mg per kilogram of body weight in humans can be lethal.[11] Concerns about dangerous side-effects and rapidly developing cataracts[12] resulted in DNP being discontinued in the United States by the end of 1938.[13] DNP, however, continues to be used by some bodybuilders and athletes to rapidly lose body fat. Fatal overdoses include cases of accidental exposure,[14] suicide,[11][15][16] and excessive intentional exposure (overdose).[15][17][18] The substance's use as a dieting aid has also led to a number of accidental fatalities.[19][20][21][22][23][24] Although DNP is widely considered too dangerous for clinical use, its mechanism of action remains under investigation as a potential approach for treating obesity.[25] Currently, research is being conducted on uncoupling proteins naturally found in humans.