Set point actually does make sense, but not in the way that fats want it to. It has to do with unconscious self-regulation and an "understanding" of how much calories you eat. "Naturally" thin people have a tendency to overestimate how many calories they eat, and to self-regulate to a lower number of calories. "Naturally" fat people have a tendency to underestimate how many calories they eat, and to self-regulate to a higher number of calories. If both of those groups of people were allowed to eat food in whatever quantities they desired, the non-hams would eat less than the hams without having to put much thought into it. This is why "dieting doesn't work" -- because if you have a tendency to underestimate the amount of food you're eating, you will regain weight. And if you eat a certain amount of calories every day without thinking about it, you'll maintain a certain weight without thinking about it. That's not the "your body will defy physics just to keep on those 50 lbs of lard" that fats want to hear. Rather, it's an explanation that points to their unawareness of how much food they're stuffing in their gobs, which is probably why I haven't heard it being used as an explanation for their disgusting forms. "I'm fat because I don't count and consciously regulate how many calories I eat!" Yeah, I can tell. The obvious solution is to track how much food you eat by means of a food scale and calorie counter, until you reach a point where you "naturally" eat what is needed to maintain a healthy weight. But will fats do that? Nope.