Male obesity is associated with increased aromatase activity within adipocytes resulting in peripheral conversion of testosterone into oestradiol and a subsequent rise in serum oestradiol levels.[2] Oestradiol in turn exerts a negative feedback effect on LH secretion from the pituitary, modulated by the presence of oestrogen receptors located in the hypothalamo–pituitary unit. Oestradiol therefore suppresses the HPT axis and leads to a reduction in plasma testosterone levels and SH.   source In other words: obesity makes a man genderless.