I was diagnosed with depression when I was 12. I've been on and off mostly everything on the market since then. I even did a course of ECT ("shock therapy") about 4 years ago as treatment for the depression. I'm on 100mg of Seroquel right now. I was previously on lithium, but had to switch off it before getting pregnant because I was told it was a no-go for pregnancy. I started at a relatively small dose of Seroquel (I think 25mg) while I was still tapering off the lithium, and then went to 50mg of the Seroquel only. I was on that dosage since probably about May, and was actually able to lose weight before getting pregnant by carefully counting my calories and exercising. I still count my calories, but now am gaining weight (due to the pregnancy, not the medication). The Seroquel definitely makes me sleepy at night, but I also had trouble with insomnia in the past, so I find it kind of helpful. If you're having trouble with the Seroquel making you sleepy, maybe ask your doctor about the Extended Release (XR) version? My doctor had me on that for a few weeks, but I couldn't sleep at all, so I switched back to the regular stuff.