So, major shocker here, eat less and move more. Eating less, as well as eating the right types of foods, will help to keep blood sugar low, and insulin response high, and moving more ( exercise ) will lower blood levels of triglycerides as the body uses them for energy.  To add to this, the bolded is very important. There's a tribe in africa that still gets their food by hunting/gathering, so they eat a diet that humans evolved to thrive on for millions of years (lots of fiber from roots, meat, vegetables, berries, etc and if they want something sweet they will raid a bee hive for honey)...they are also one of the healthiest groups of people studied on Earth, with 0 history of obesity-related diseases like heart disease or high cholesterol. Infants/toddlers have a low survival rate, but the kids that do survive grow to live very long, healthy lives. The thing is that humans did not evolve to subsist on high-sugar/processed foods, which is why all these fatasses are so unhealthy because they over-consume what the human body is meant to process for optimal health/survival. That is why the healthiest place to get your food will always be from the fresh produce section, not from the center aisles which are filled with processed/canned junk or food with 'added' nutrients (which tend to have too much sugar in them, despite other health claims).