Everything you said is true, but it's also worth noting that the discussed leptin resistance is caused by obesity. This isn't even a situation where someone is born without a sense of satiety, but instead it's a situation where someone eats so much that its sense of satiety burns out. "Oh, no! I can't lose weight because I'm so fat that my leptin receptors stopped working." How the fuck is a problem that you caused by being fat, an excuse for becoming fat, piggy? Yet another example of cause and effect being completely beyond the mental capacity of fatties.