High fructose corn syrup is particularly troubling largely because it is EVERYWHERE and in EVERYTHING. What not too many people realize is that it gets metabolized in the body differently. In addition to what it does in regard to insulin response, its overconsumption over time leads to fatty liver disease, it became so prominent that they had to classify it as non-alcoholic fatty liver disease.  The level of depth some people have discussed with what it does to the body from a metabolic stand point emphasizes a lot of the direct and indirect issues of overconsuming such substances. And I have not even gotten to how it manipulates the mind