to be fair on that, there are ones that make you Predisposed to lose weight and others that make you predisposed to gain based on how it affects hunger.  Still no excuse, the only reason is some make you hungrier.  And everyone also reacts differently. I've been on them and once I realized I was gaining I payed more attention to my portions, etc, and lost it. I imagine that the fatties just accept it as the way things are without realizing the mechanism it works in lol