I'm pretty sick, and I think I'm past the point where any new medications are going to give me big bumps in my quality of life. I've had to give a lot of thought to what I'd consider an unacceptable quality of life as I decline. And I'm often struck by the fact that a disturbing number of people without any real medical issues are below the 'time for euthanasia' point I've set for myself. And I don't think I've set overly high standards or anything.