My dad has RA. He was given methotrexate, as you'd expect. Then it gave him a seizure.  You see, my dad is also epileptic, and his ham of a doctor (yes, DOCTOR), didn't bother to look up whether or not you can mix methotrexate with his epilepsy meds (pro tip, you can't).  Dad nearly died. 'Cos of the law here in the UK, he now can't drive for 6 months or so ('cos he had a seizure), meaning he can't make it to work, meaning the family is in financial trouble... All because one fat ass was too lazy to do his fucking job and find an alternative medication. The kicker? New, thin doctor found a combination therapy that keeps the RA in check, and doesn't screw with dad's epilepsy. Took her 5 minutes on her computer. We watched her do it.