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Departments of Clinical Medicine and Neurology (R.C., B.T., B.F.) and Normal Human Morphology (F.C., S.Z., E.R., M.G., G.Z.), University of Trieste, Trieste; Diabetic Center, A.S.S. 1 Triestina, Trieste (R.C.); and Medicine Laboratory, International Center for Genetic Engineering and Biotechnology, Trieste (S.Z., M.G.), Italy." } ], "person_or_org": { "family_name": "Toffoli", "given_name": "Barbara", "name": "Toffoli, Barbara", "type": "personal" } }, { "affiliations": [ { "name": "From the Department of Morphology and Embryology, University of Ferrara, Ferrara (P.S., E.R.); Departments of Clinical Medicine and Neurology (R.C., B.T., B.F.) and Normal Human Morphology (F.C., S.Z., E.R., M.G., G.Z.), University of Trieste, Trieste; Diabetic Center, A.S.S. 1 Triestina, Trieste (R.C.); and Medicine Laboratory, International Center for Genetic Engineering and Biotechnology, Trieste (S.Z., M.G.), Italy." } ], "person_or_org": { "family_name": "Rimondi", "given_name": "Erika", "name": "Rimondi, Erika", "type": "personal" } }, { "affiliations": [ { "name": "From the Department of Morphology and Embryology, University of Ferrara, Ferrara (P.S., E.R.); Departments of Clinical Medicine and Neurology (R.C., B.T., B.F.) and Normal Human Morphology (F.C., S.Z., E.R., M.G., G.Z.), University of Trieste, Trieste; Diabetic Center, A.S.S. 1 Triestina, Trieste (R.C.); and Medicine Laboratory, International Center for Genetic Engineering and Biotechnology, Trieste (S.Z., M.G.), Italy." } ], "person_or_org": { "family_name": "Fabris", "given_name": "Bruno", "name": "Fabris, Bruno", "type": "personal" } }, { "affiliations": [ { "name": "From the Department of Morphology and Embryology, University of Ferrara, Ferrara (P.S., E.R.); Departments of Clinical Medicine and Neurology (R.C., B.T., B.F.) and Normal Human Morphology (F.C., S.Z., E.R., M.G., G.Z.), University of Trieste, Trieste; Diabetic Center, A.S.S. 1 Triestina, Trieste (R.C.); and Medicine Laboratory, International Center for Genetic Engineering and Biotechnology, Trieste (S.Z., M.G.), Italy." } ], "person_or_org": { "family_name": "Giacca", "given_name": "Mauro", "name": "Giacca, Mauro", "type": "personal" } }, { "affiliations": [ { "name": "From the Department of Morphology and Embryology, University of Ferrara, Ferrara (P.S., E.R.); Departments of Clinical Medicine and Neurology (R.C., B.T., B.F.) and Normal Human Morphology (F.C., S.Z., E.R., M.G., G.Z.), University of Trieste, Trieste; Diabetic Center, A.S.S. 1 Triestina, Trieste (R.C.); and Medicine Laboratory, International Center for Genetic Engineering and Biotechnology, Trieste (S.Z., M.G.), Italy." } ], "person_or_org": { "family_name": "Zauli", "given_name": "Giorgio", "name": "Zauli, Giorgio", "type": "personal" } } ], "description": "Background\u2014\n \n Although in vitro studies have suggested that tumor necrosis factor\u2013related apoptosis-inducing ligand (TRAIL) might be involved in vascular biology, its potential role in the pathogenesis and/or treatment of atherosclerosis has not been investigated.\n \n \n \n Methods and Results\u2014\n \n Both recombinant human TRAIL and an adeno-associated virus vector expressing human TRAIL were used to deliver TRAIL in apolipoprotein E (apoE)\u2013null mice in which diabetes mellitus was induced by destruction of islet cells with streptozotocin. Diabetes in apoE-null mice was associated with a significant increase in atherosclerotic plaque area and complexity in the aorta as assessed by a marked increase in interstitial collagen, cellular proliferation, and macrophage infiltration and a focal loss of endothelial coverage. Repeated intraperitoneal injections of recombinant human TRAIL and a single intravenous injection of adeno-associated virus\u2013human TRAIL significantly attenuated the development of atherosclerotic plaques in apoE-null animals. TRAIL also markedly affected the cellular composition of plaque lesions by inducing apoptosis of infiltrating macrophages and increasing the vascular smooth muscle cell content. Moreover, TRAIL promoted the in vitro migration of cultured human aortic vascular smooth muscle cells but not of monocytes or macrophages. Conversely, TRAIL selectively induced apoptosis of human cultured macrophages but not of vascular smooth muscle cells.\n \n \n \n Conclusions\u2014\n \n Overall, data from the present study indicate that atherosclerosis in diabetic apoE-null mice is ameliorated by systemic TRAIL administration and that adeno-associated virus\u2013mediated TRAIL gene delivery might represent an innovative method for the therapy of diabetic vascular diseases.", "languages": [ { "id": "eng", "title": { "en": "English" } } ], "publication_date": "2006-09-26", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "" }, "id": "other-open", "title": { "en": "Other (Open)" } } ], "title": "Systemic Tumor Necrosis Factor\u2013Related Apoptosis-Inducing Ligand Delivery Shows Antiatherosclerotic Activity in Apolipoprotein E\u2013Null Diabetic Mice" }, "parent": { "access": { "owned_by": { "user": "1231459" }, "settings": { "accept_conditions_text": null, "allow_guest_requests": false, "allow_user_requests": false, "secret_link_expiration": 0 } }, "communities": { "default": "1cbc1580-a34f-40cd-b001-c0cbc1b1083c", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_submission_policy": "open", "review_policy": "members", "visibility": "public" }, "children": { "allow": false }, "created": "2024-12-07T16:00:25.151710+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "1cbc1580-a34f-40cd-b001-c0cbc1b1083c", "links": {}, "metadata": { "description": "Mirror of bronze OA or gold OA papers connected to Italy.", "title": "Italy papers mirror", "type": { "id": "topic" } }, "revision_id": 4, "slug": "it-mirror", "updated": "2024-12-07T16:01:13.249552+00:00" } ], "ids": [ "1cbc1580-a34f-40cd-b001-c0cbc1b1083c" ] }, "id": "14492528", "pids": {} }, "pids": { "doi": { "identifier": "10.1161/circulationaha.106.643841", "provider": "external" }, "oai": { "identifier": "oai:zenodo.org:14492529", "provider": "oai" } }, "revision_id": 5, "stats": { "all_versions": { "data_volume": 84971875.0, "downloads": 125, "unique_downloads": 123, "unique_views": 14, "views": 14 }, "this_version": { "data_volume": 84971875.0, "downloads": 125, "unique_downloads": 123, "unique_views": 14, "views": 14 } }, "status": "published", "swh": {}, "updated": "2024-12-15T08:46:03.374560+00:00", "versions": { "index": 1, "is_latest": true } }