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\u2020 Istituti Ortopedici Rizzoli, Bologna, Italy;" } ], "person_or_org": { "family_name": "Landuzzi", "given_name": "Lorena", "name": "Landuzzi, Lorena", "type": "personal" } }, { "affiliations": [ { "name": "*Cancer Research Section, Department of Experimental Pathology, University of Bologna, Bologna, Italy;; \u2020 Istituti Ortopedici Rizzoli, Bologna, Italy;" } ], "person_or_org": { "family_name": "Nicoletti", "given_name": "Giordano", "name": "Nicoletti, Giordano", "type": "personal" } }, { "affiliations": [ { "name": "*Cancer Research Section, Department of Experimental Pathology, University of Bologna, Bologna, Italy;" } ], "person_or_org": { "family_name": "De Giovanni", "given_name": "Carla", "name": "De Giovanni, Carla", "type": "personal" } }, { "affiliations": [ { "name": "*Cancer Research Section, Department of Experimental Pathology, University of Bologna, Bologna, Italy;" } ], "person_or_org": { "family_name": "Rossi", "given_name": "Ilaria", "name": "Rossi, Ilaria", "type": "personal" } }, { "affiliations": [ { "name": "*Cancer Research Section, Department of Experimental Pathology, University of Bologna, Bologna, Italy;" } ], "person_or_org": { "family_name": "Croci", "given_name": "Stefania", "name": "Croci, Stefania", "type": "personal" } }, { "affiliations": [ { "name": "*Cancer Research Section, Department of Experimental Pathology, University of Bologna, Bologna, Italy;" } ], "person_or_org": { "family_name": "Astolfi", "given_name": "Annalisa", "name": "Astolfi, Annalisa", "type": "personal" } }, { "affiliations": [ { "name": "\u2021 Aging Research Center, G. D'Annunzio University Foundation, Chieti, Italy; and" } ], "person_or_org": { "family_name": "Iezzi", "given_name": "Manuela", "name": "Iezzi, Manuela", "type": "personal" } }, { "affiliations": [ { "name": "\u2021 Aging Research Center, G. D'Annunzio University Foundation, Chieti, Italy; and" } ], "person_or_org": { "family_name": "Di Carlo", "given_name": "Emma", "name": "Di Carlo, Emma", "type": "personal" } }, { "affiliations": [ { "name": "\u2021 Aging Research Center, G. D'Annunzio University Foundation, Chieti, Italy; and" } ], "person_or_org": { "family_name": "Musiani", "given_name": "Piero", "name": "Musiani, Piero", "type": "personal" } }, { "affiliations": [ { "name": "\u00a7 Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy" } ], "person_or_org": { "family_name": "Forni", "given_name": "Guido", "name": "Forni, Guido", "type": "personal" } }, { "affiliations": [ { "name": "*Cancer Research Section, Department of Experimental Pathology, University of Bologna, Bologna, Italy;" } ], "person_or_org": { "family_name": "Lollini", "given_name": "Pier-Luigi", "name": "Lollini, Pier-Luigi", "type": "personal" } } ], "description": "Abstract\n A vaccine combining IL-12 and allogeneic mammary carcinoma cells expressing p185neu completely prevents tumor onset in HER-2/neu transgenic BALB/c mice (NeuT mice). The immune protection elicited was independent from CTL activity. We now formally prove that tumor prevention is mainly based on the production of anti-p185neu Abs. In the present studies, NeuT mice were crossed with knockout mice lacking IFN-\u03b3 production (IFN-\u03b3\u2212/\u2212) or with B cell-deficient mice (\u03bcMT). Vaccination did not protect NeuT-IFN-\u03b3\u2212/\u2212 mice, thus confirming a central role of IFN-\u03b3. The block of Ab production in NeuT-\u03bcMT mice was incomplete. About one third of NeuT-\u03bcMT mice failed to produce Abs and displayed a rapid tumor onset. By contrast, those NeuT-\u03bcMT mice that responded to the vaccine with a robust production of anti-p185neu Ab displayed a markedly delayed tumor onset. In these NeuT-\u03bcMT mice, the vaccine induced a lower level of IgG2a and IgG3 and a higher level of IgG2b than in NeuT mice. Moreover, NeuT-\u03bcMT mice failed to produce anti-MHC class I Abs in response to allogeneic H-2q molecules present in the cell vaccine. These findings show that inhibition of HER-2/neu carcinogenesis depends on cytokines and specific Abs, and that a highly effective vaccine can rescue Ab production even in B cell-deficient mice.", "languages": [ { "id": "eng", "title": { "en": "English" } } ], "publication_date": "2014-04-22", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "" }, "id": "other-open", "title": { "en": "Other (Open)" } } ], "title": "Immunoprevention of Mammary Carcinoma in HER-2/neu Transgenic Mice Is IFN-\u03b3 and B Cell Dependent" }, "parent": { "access": { "owned_by": { "user": "1231459" }, "settings": { "accept_conditions_text": null, "allow_guest_requests": false, "allow_user_requests": false, "secret_link_expiration": 0 } }, "communities": { "default": "1cbc1580-a34f-40cd-b001-c0cbc1b1083c", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_submission_policy": "open", "review_policy": "members", "visibility": "public" }, "children": { "allow": false }, "created": "2024-12-07T16:00:25.151710+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "1cbc1580-a34f-40cd-b001-c0cbc1b1083c", "links": {}, "metadata": { "description": "Mirror of bronze OA or gold OA papers connected to Italy.", "title": "Italy papers mirror", "type": { "id": "topic" } }, "revision_id": 4, "slug": "it-mirror", "updated": "2024-12-07T16:01:13.249552+00:00" } ], "ids": [ "1cbc1580-a34f-40cd-b001-c0cbc1b1083c" ] }, "id": "14368422", "pids": {} }, "pids": { "doi": { "identifier": "10.4049/jimmunol.173.4.2288", "provider": "external" }, "oai": { "identifier": "oai:zenodo.org:14368423", "provider": "oai" } }, "revision_id": 5, "stats": { "all_versions": { "data_volume": 82952702.0, "downloads": 59, "unique_downloads": 59, "unique_views": 19, "views": 19 }, "this_version": { "data_volume": 82952702.0, "downloads": 59, "unique_downloads": 59, "unique_views": 19, "views": 19 } }, "status": "published", "swh": {}, "updated": "2024-12-10T21:37:14.855734+00:00", "versions": { "index": 1, "is_latest": true } }