SIB Swiss Institute of Bioinformatics - Biodata Resources
Published December 10, 2024 | Version v1
Dataset Open

neXtProt ion channels variants portal

Authors/Creators

  • 1. ROR icon SIB Swiss Institute of Bioinformatics
  • 2. ROR icon University of Bern

Description

This portal provides information about the functional impact of genetic variants and artificially generated mutants. Annotation statements are triplets composed of (1) a subject, which corresponds to the protein variant being annotated; (2) a relation describing how the property is affected, and (3) an object that describes the function, localization, or protein property being tested.

Files

Caloha_readme.txt.txt

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Additional details

Funding

Swiss National Science Foundation
CR33I3_156233

References

  • Hinard V, Britan A, Schaeffer M, Zahn-Zabal M, Thomet U, Rougier JS, Bairoch A, Abriel H, Gaudet P. Annotation of functional impact of voltage-gated sodium channel mutations. Hum Mutat. 2017 Feb 7. doi: 10.1002/humu.23191.
  • Hinard V, Britan A, Rougier JS, Bairoch A, Abriel H, Gaudet P. ICEPO: the ion channel electrophysiology ontology. Database (Oxford). 2016 Apr 7;2016. pii: baw017. doi: 10.1093/database/baw017.
  • Gaudet P, Michel PA, Zahn-Zabal M, Britan A, Cusin I, Domagalski M, Duek PD, Gateau A, Gleizes A, Hinard V, Rech de Laval V, Lin JJ, Nikitin F, Schaeffer M, Teixeira D, Lane L, Bairoch A. The neXtProt knowledgebase on human proteins: 2017 update. Nucl. Acids Res. 2017 Jan 4;45(D1):D177-D182.