Late subsequent leukemia after childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS)

The dataset contains all variables of interest presented in the study. By downloading and using these data, you agree that you will cite the appropriate publication in any communications or publications arising directly or indirectly from these data; for utilization of data available prior to publication, you agree to respect the requested responsibilities of resource users under 2003 Fort Lauderdale principles; you agree that you will never attempt to identify any participant. 

When using downloaded data, please cite corresponding paper and this repository:

Ghosh, T., Hyun, G., Dhaduk, R., Conces, M., Arnold, M. A., Howell, R. M., Henderson, T. O., McDonald, A., Robison, L. L., Yasui, Y., Ness, K. K., Armstrong, G. T., Neglia, J. P., & Turcotte, L. M. (2024). Late subsequent leukemia after childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS). Cancer Medicine, 13(20). https://doi.org/10.1002/cam4.70086

Funding:

This work was supported by the National Cancer Institute (CA55727, G.T. Armstrong, Principal Investigator). Support to St. Jude Children’s Research Hospital also provided by the Cancer Center Support (CORE) grant (CA21765, C. Roberts, Principal Investigator) and the American Lebanese-Syrian Associated Charities (ALSAC).

Data dictionary:   

Sex: Sex of patient
dxgroup: Diagnosis group
splenectomy: Splenectomy
dxyrgrp: Diagnosis year group
late_leukemia: Late Leukemia Categories
age_dx: Age at Diagnosis
agedxgrp: Age at Diagnosis Categories
race_ethgrp: Race/Ethnic group
anthgrp: Anthracycline group
epipgrp: Epipodophyllotoxin group
alkgrp: Alkylating agent group
pltgrp: Platinum agents group
radgrp: Radiation group
maxrtdose: Maximum radiation dose to anybody region (Gy)
livedead: Alive or dead
dx_snleukemia: Years from primary to secondary diagnosis Categories
dx_snleukemia_yr: Time from primary to secondary diagnosis (Years)
a_snleukemia_grp: Age at leukemia diagnosis Categories
a_snleukemia: Age at leukemia diagnosis (Years)
survival_snleukemia: Survival after leukemia diagnosis (Years)
surv_snleukemia_grp: Survival after leukemia diagnosis Categories
cause_mortality: Cause of Mortality
d_lcontact_org: Date of last contact (last questionnaire or death)
u_causeicd10: Underlying cause of death (ICD10: 2007+ NDI
u_causeicd9: Underlying cause of death (ICD9: 2002 NDI)
causecat2002: Cause category (2002 NDI data only)
deathinNDI: Death data from NDI
a_dx: Age at diagnosis
d_entry: Date of study entry (5 years from Date of diagnosis)
a_entry: Age at study entry
a_death: Age at death
a_fu1: Age at follow-up 1
a_fu3: Age at follow-up 3
a_fu6: Age at follow-up 6
a_lcontact: Age at last contact
fweight: Sampling weight
hsct: Hematopoietic cell transplantation
late_leukemia_D1: Late Leukemia Group
late_leukemia_D2: Very Late Leukemia Group
lineage: Cell Lineage
smk_status: Smoking Status
leukemia_dx: Leukemia Diagnosis Categories