TIER 1 - SNV/INDEL

POLE/MMR deficiency


TIER 2 - SNV/INDEL

POLD1/MMR deficiency


sCNA

MUTYH/BER deficiency


TUMOR PURITY

MUTYH/BER deficiency


TUMOR PLOIDY

Aristolochic acid exposure


MSI STATUS

POLD1/MMR deficiency


DOMINANT SIGNATURE ETIOLOGY

Sequencing artefact


MUTATIONAL BURDEN


KATAEGIS EVENTS