ENSG,Name,Class,Type,core/var,Disease causing,Tissue
ENSG00000187608,ISG15,ubiquitin and UBL proteins,ISG15,variable,yes,Whole Blood
ENSG00000157911,PEX10,E3 ligase ,PEX,variable,yes,"Nerve, Muscle - Skeletal, Kidney, Liver, Heart, Brain"
ENSG00000162601,MYSM1,Ub and UBL demodifiers,assorted,variable,yes,"Bone Marrow, Whole Blood"
ENSG00000159377,PSMB4,proteasome & associates,constitutive,variable,yes,Whole Blood
ENSG00000132716,DCAF8,E3 ligase ,DCAF,variable,yes,Nerve
ENSG00000143222,UFC1,E2 conjugating enzymes,nan,core,yes,Brain
ENSG00000135870,RC3H1,E3 ligase ,Roquin,variable,yes,Whole Blood
ENSG00000116679,IVNS1ABP,E3 ligase ,BTB,variable,yes,Whole Blood
ENSG00000077152,UBE2T,E2 conjugating enzymes,UBC domain & C-terminal extension,variable,yes,Whole Blood
ENSG00000198625,MDM4,E3 ligase ,Mdm,variable,yes,Whole Blood
ENSG00000162923,WDR26,E3 ligase ,subunit,variable,yes,Brain
ENSG00000010072,SPRTN,p97 and associates,metalloprotease,variable,yes,Liver
ENSG00000168264,IRF2BP2,E3 ligase ,IRF2 binding,variable,yes,Whole Blood
ENSG00000116957,TBCE,ubiquitin and UBL proteins,chaperones and related,variable,yes,Bone
ENSG00000138081,FBXO11,E3 ligase ,F-box,variable,yes,Brain
ENSG00000124356,STAMBP,Ub and UBL demodifiers,assorted,variable,yes,Multisystem
ENSG00000153201,RANBP2,E3 ligase ,sumoylation,core,yes,Brain
ENSG00000153107,ANAPC1,E3 ligase ,subunit,variable,yes,Skin
ENSG00000239474,KLHL41,E3 ligase ,BTB,variable,yes,Muscle - Skeletal
ENSG00000115827,DCAF17,E3 ligase ,DCAF,variable,yes,Multisystem
ENSG00000116044,NFE2L2,proteasome & associates,transcription factor,variable,yes,"Brain, Whole Blood, Heart, Liver"
ENSG00000138411,HECW2,E3 ligase ,WW & C2,variable,yes,"Brain, Muscle - Skeletal"
ENSG00000116030,SUMO1,ubiquitin and UBL proteins,SUMO,core,yes,Face
ENSG00000138376,BARD1,E3 ligase ,BRCA1-associated,variable,yes,Breast
ENSG00000135924,DNAJB2,ubiquitin and UBL binding,HSP70 cochaperone,variable,yes,"Brain, Muscle - Skeletal"
ENSG00000036257,CUL3,E3 ligase ,Cullin,variable,yes,"Brain, Kidney"
ENSG00000153827,TRIP12,proteasome & associates,HECT,variable,yes,"Muscle - Skeletal, Liver, Brain"
ENSG00000113851,CRBN,E3 ligase ,DCAF,core,yes,Brain
ENSG00000134086,VHL,E3 ligase ,VHL,variable,yes,"Whole Blood, Brain, Adrenal gland, Kidney, Ovary, Testis, Vacular"
ENSG00000151092,NGLY1,proteasome & associates,deglycosylase,variable,yes,Multisystem
ENSG00000206557,TRIM71,E3 ligase ,TRIM,variable,yes,Brain
ENSG00000157119,KLHL40,E3 ligase ,BTB,variable,yes,Muscle - Skeletal
ENSG00000183763,TRAIP,E3 ligase ,other,variable,yes,Multisystem
ENSG00000114737,CISH,E3 ligase ,SOCS box,variable,yes,Whole Blood
ENSG00000163930,BAP1,Ub and UBL demodifiers,nan,variable,yes,Multisystem
ENSG00000163635,ATXN7,ubiquitin and UBL binding,activation,variable,yes,Brain
ENSG00000081307,UBA5,E1 activating enzymes,nan,variable,yes,Brain
ENSG00000082996,RNF13,E3 ligase ,Goliath,variable,yes,Brain
ENSG00000114796,KLHL24,E3 ligase ,BTB,variable,yes,Skin
ENSG00000163961,RNF168,E3 ligase ,other,variable,yes,"Whole Blood, Brain"
ENSG00000178222,RNF212,E3 ligase ,other,variable,yes,Testis
ENSG00000035928,RFC1,ubiquitin and UBL binding,DNA polymerase clamp loader,variable,yes,"Brain, Nerve"
ENSG00000154277,UCHL1,Ub and UBL demodifiers,nan,variable,yes,"Brain, Nerve"
ENSG00000205678,TECRL,ubiquitin and UBL proteins,assorted enzymes ,variable,yes,Heart
ENSG00000163104,SMARCAD1,ubiquitin and UBL binding,chromatin remodeling,variable,yes,Skin
ENSG00000138778,CENPE,ubiquitin and UBL binding,SIM,variable,yes,Brain
ENSG00000109654,TRIM2,E3 ligase ,TRIM,variable,yes,Nerve
ENSG00000109775,UFSP2,Ub and UBL demodifiers,deURMylase,variable,yes,"Bone, Brain"
ENSG00000145495,6-Mar,E3 ligase ,MARCH,core,yes,Brain
ENSG00000154124,OTULIN,Ub and UBL demodifiers,assorted,variable,yes,Whole Blood
ENSG00000095015,MAP3K1,E3 ligase ,other,variable,yes,Testis
ENSG00000049167,ERCC8,E3 ligase ,DCAF,variable,yes,"Brain, Nerve, Skin"
ENSG00000172062,SMN1,ubiquitin and UBL binding,mRNA splicing,variable,yes,Muscle - Skeletal
ENSG00000152422,XRCC4,ubiquitin and UBL binding,DNA repair accessory,variable,yes,Multisystem
ENSG00000152503,TRIM36,E3 ligase ,TRIM,variable,yes,Brain
ENSG00000146021,KLHL3,E3 ligase ,BTB,variable,yes,Kidney
ENSG00000145868,FBXO38,E3 ligase ,F-box,core,yes,Brain
ENSG00000072803,FBXW11,E3 ligase ,F-box,variable,yes,Brain
ENSG00000161011,SQSTM1,proteasome & associates,PB1,variable,yes,"Brain, Muscle - Skeletal, Bone"
ENSG00000187566,NHLRC1,E3 ligase ,other,variable,yes,Brain
ENSG00000111802,TDP2,ubiquitin and UBL binding,5'-tyrosyl DNA phosphodiesterase,variable,yes,Brain
ENSG00000204264,PSMB8,proteasome & associates,specialized,variable,yes,Whole Blood
ENSG00000240065,PSMB9,proteasome & associates,specialized,variable,yes,Whole Blood
ENSG00000044090,CUL7,E3 ligase ,Cullin,variable,yes,Testis
ENSG00000170734,POLH,ubiquitin and UBL binding,DNA polymerase,variable,yes,Skin
ENSG00000146247,PHIP,E3 ligase ,DCAF,variable,yes,Multisystem
ENSG00000112234,FBXL4,E3 ligase ,F-box,variable,yes,"Brain, Muscle - Skeletal"
ENSG00000123552,USP45,Ub and UBL demodifiers,UBP-ZnF,variable,yes,Eye
ENSG00000085382,HACE1,E3 ligase ,ankyrin repeats,variable,yes,Brain
ENSG00000081087,OSTM1,E3 ligase ,none,variable,yes,Bone
ENSG00000056972,TRAF3IP2,E3 ligase ,nan,variable,yes,Whole Blood
ENSG00000118503,TNFAIP3,E3 ligase ,with OTU,variable,yes,Whole Blood
ENSG00000055208,TAB2,ubiquitin and UBL binding,RanBP2-type ZnF,variable,yes,Heart
ENSG00000011275,RNF216,E3 ligase ,assorted,variable,yes,"Brain, Pituitary gland, Testis, Ovary"
ENSG00000122550,KLHL7,E3 ligase ,BTB,variable,yes,"Brain, Muscle - Skeletal"
ENSG00000146926,ASB10,E3 ligase ,SOCS box,variable,yes,Eye
ENSG00000008853,RHOBTB2,E3 ligase ,BTB,variable,yes,Brain
ENSG00000104365,IKBKB,ubiquitin and UBL proteins,assorted enzymes ,variable,yes,Whole Blood
ENSG00000120925,RNF170,E3 ligase ,other,variable,yes,Brain
ENSG00000164751,PEX2,E3 ligase ,PEX,variable,yes,Multisystem
ENSG00000155100,OTUD6B,Ub and UBL demodifiers,assorted,variable,yes,Brain
ENSG00000170881,RNF139,E3 ligase ,other,variable,yes,Kidney
ENSG00000156831,NSMCE2,E3 ligase ,sumoylation,variable,yes,Multisystem
ENSG00000071894,CPSF1,E3 ligase ,CRL adaptor,variable,yes,Eye
ENSG00000137055,PLAA,p97 and associates,PLA activator,variable,yes,Brain
ENSG00000197579,TOPORS,E3 ligase ,other,variable,yes,Eye
ENSG00000165280,VCP,p97 and associates,nan,variable,yes,"Nerve, Brain,Muscle - Skeletal"
ENSG00000119401,TRIM32,E3 ligase ,TRIM,variable,yes,"Muscle - Skeletal, Testis, Brain, Kidney, Vagina, Adipose tissue"
ENSG00000148356,LRSAM1,E3 ligase ,other,variable,yes,Nerve
ENSG00000122877,EGR2,E3 ligase ,nan,variable,yes,Nerve
ENSG00000213341,CHUK,ubiquitin and UBL proteins,assorted enzymes ,variable,yes,Multisystem
ENSG00000166326,TRIM44,E3 ligase ,TRIM,variable,yes,Eye
ENSG00000134574,DDB2,E3 ligase ,DCAF,variable,yes,Skin
ENSG00000165917,RAPSN,E3 ligase ,other,variable,yes,Multisystem
ENSG00000074266,EED,E3 ligase ,DCAF,variable,yes,Multisystem
ENSG00000137693,YAP1,ubiquitin and UBL binding,coactivation and corepression,variable,yes,"Eye, Brain"
ENSG00000160584,SIK3,ubiquitin and UBL binding,salt-inducible Ser/Thr kinases,variable,yes,Bone
ENSG00000160695,VPS11,E3 ligase ,VPS-associated,core,yes,"Brain, Muscle - Skeletal"
ENSG00000110395,CBL,E3 ligase ,"CBL, UBA",variable,yes,"Whole Blood, Heart, Brain"
ENSG00000123297,TSFM,ubiquitin and UBL binding,mitochondrial,variable,yes,"Heart, Muscle - Skeletal, Brain, Liver"
ENSG00000183735,TBK1,ubiquitin and UBL proteins,assorted enzymes ,core,yes,Brain
ENSG00000135679,MDM2,E3 ligase ,Mdm,variable,yes,"Skin, Artery, Kidney"
ENSG00000139323,POC1B,E3 ligase ,DCAF,variable,yes,Eye
ENSG00000151148,UBE3B,E3 ligase ,IQ motif,variable,yes,"Eye, Brain"
ENSG00000151835,SACS,ubiquitin and UBL proteins,chaperones and related,variable,yes,"Nerve, Brain"
ENSG00000127870,RNF6,E3 ligase ,other,variable,yes,Esophagus
ENSG00000132963,POMP,proteasome & associates,core particle,variable,yes,"Skin, Whole Blood"
ENSG00000120686,UFM1,ubiquitin and UBL proteins,UFM1,variable,yes,Brain
ENSG00000136144,RCBTB1,E3 ligase ,BTB,variable,yes,Eye
ENSG00000005812,FBXL3,E3 ligase ,F-box,variable,yes,Brain
ENSG00000100902,PSMA6,proteasome & associates,constitutive,variable,yes,Heart
ENSG00000119669,IRF2BPL,E3 ligase ,IRF2 binding,core,yes,Brain
ENSG00000066427,ATXN3,p97 and associates,Josephin,variable,yes,Brain
ENSG00000131323,TRAF3,E3 ligase ,"TRAF-type ZnF, MATH/TRAF ",variable,yes,Brain
ENSG00000075413,MARK3,ubiquitin and UBL binding,microtubule-associated Ser/Thr kinases,core,yes,Eye
ENSG00000179455,MKRN3,E3 ligase ,Makorin,variable,yes,Multisystem
ENSG00000254585,MAGEL2,E3 ligase ,MAGE,variable,yes,Multisystem
ENSG00000114062,UBE3A,proteasome & associates,HECT,variable,yes,Brain
ENSG00000128731,HERC2,E3 ligase ,RCC1,variable,yes,"Skin, Brain"
ENSG00000185115,NSMCE3,E3 ligase ,MAGE,variable,yes,"Lung, Whole Blood"
ENSG00000198690,FAN1,ubiquitin and UBL binding,DNA exonuclease,variable,yes,Kidney
ENSG00000128829,EIF2AK4,ubiquitin and UBL binding,other Ser/Thr kinase,variable,yes,Lung
ENSG00000159459,UBR1,proteasome & associates,UBR,variable,yes,"Pancreas, Brain"
ENSG00000138592,USP8,Ub and UBL demodifiers,"dimerization, rhodanese-like ",variable,yes,Brain
ENSG00000103657,HERC1,E3 ligase ,RCC1,variable,yes,Brain
ENSG00000103671,TRIP4,ubiquitin and UBL binding,ribosome QC & transcriptional activation,variable,yes,Muscle - Skeletal
ENSG00000234438,KBTBD13,E3 ligase ,BTB,variable,yes,Muscle - Skeletal
ENSG00000140464,PML,E3 ligase ,TRIM,variable,yes,Whole Blood
ENSG00000103266,STUB1,E3 ligase ,UBOX,variable,yes,Brain
ENSG00000131653,TRAF7,E3 ligase ,TRAF-type ZnF,variable,yes,"Brain, Heart, Muscle - Skeletal"
ENSG00000162063,CCNF,E3 ligase ,F-box,variable,yes,Brain
ENSG00000103313,MEFV,E3 ligase ,TRIM,variable,yes,Whole Blood
ENSG00000188827,SLX4,ubiquitin and UBL binding,DNA endonuclease cofactor,variable,yes,Whole Blood
ENSG00000005339,CREBBP,ubiquitin and UBL binding,activation,core,yes,Brain
ENSG00000187555,USP7,ubiquitin and UBL proteins,DUB,core,yes,Multisystem
ENSG00000089280,FUS,ubiquitin and UBL binding,DNA/RNA binding protein,core,yes,Brain
ENSG00000140691,ARMC5,E3 ligase ,BTB,variable,yes,Adrenal Gland
ENSG00000083799,CYLD,Ub and UBL demodifiers,CAP Gly-rich domain,variable,yes,Skin
ENSG00000159579,RSPRY1,E3 ligase ,SPRY but not TRIM,variable,yes,Multisystem
ENSG00000140854,KATNB1,E3 ligase ,DCAF,variable,yes,Brain
ENSG00000168411,RFWD3,E3 ligase ,other,variable,yes,Whole Blood
ENSG00000261609,GAN,E3 ligase ,BTB,variable,yes,"Brain, Nerve"
ENSG00000103264,FBXO31,E3 ligase ,F-box,variable,yes,Brain
ENSG00000174231,PRPF8,ubiquitin and UBL binding,mRNA splicing,core,yes,Eye
ENSG00000007168,PAFAH1B1,E3 ligase ,DCAF,core,yes,Brain
ENSG00000108733,PEX12,E3 ligase ,PEX,variable,yes,"Nerve,Muscle - Skeletal, Kidney, Liver, Heart, Brain"
ENSG00000277258,PCGF2,ubiquitin and UBL proteins,E3 ligases,variable,yes,Multisystem
ENSG00000161594,KLHL10,E3 ligase ,BTB,variable,yes,Testis
ENSG00000012048,BRCA1,E3 ligase ,BRCA1,variable,yes,"Breast, Ovary, Whole Blood"
ENSG00000121067,SPOP,E3 ligase ,BTB,variable,yes,Brain
ENSG00000108375,RNF43,E3 ligase ,other,variable,yes,Colon
ENSG00000108395,TRIM37,E3 ligase ,TRIM,variable,yes,"Muscle - Skeletal, Liver, Brain, Heart, a lot"
ENSG00000197170,PSMD12,proteasome & associates,nonATPase,variable,yes,"Brain, Heart"
ENSG00000173821,RNF213,E3 ligase ,other,variable,yes,Brain
ENSG00000169696,ASPSCR1,p97 and associates,"UBX, UBXL, SHP",variable,yes,Lung
ENSG00000101752,MIB1,E3 ligase ,Mindbomb,variable,yes,Heart
ENSG00000101695,RNF125,E3 ligase ,TRAC-1,variable,yes,"Brain, Whole Blood , Muscle - Skeletal"
ENSG00000049759,NEDD4L,E3 ligase ,WW & C2,variable,yes,Brain
ENSG00000099797,TECR,ubiquitin and UBL proteins,assorted enzymes ,variable,yes,Brain
ENSG00000125826,RBCK1,ubiquitin and UBL proteins,E3 ligases,variable,yes,"Muscle - Skeletal, Heart"
ENSG00000198171,DDRGK1,E3 ligase ,UFMylation adaptor,core,yes,Bone
ENSG00000078747,ITCH,E3 ligase ,WW & C2,core,yes,"Whole Blood, Brain"
ENSG00000142178,SIK1,ubiquitin and UBL binding,salt-inducible Ser/Thr kinases,variable,yes,Brain
ENSG00000184979,USP18,Ub and UBL demodifiers,assorted,variable,yes,Multisystem
ENSG00000099949,LZTR1,E3 ligase ,BTB,core,yes,Multisystem
ENSG00000182944,EWSR1,ubiquitin and UBL binding,repression,core,yes,"Eye, Bone"
ENSG00000100225,FBXO7,ubiquitin and UBL proteins,E3 ligases,variable,yes,Brain
ENSG00000100379,KCTD17,E3 ligase ,BTB,variable,yes,"Muscle - Skeletal, Brain"
ENSG00000101849,TBL1X,E3 ligase ,none,variable,yes,Thyroid
ENSG00000101871,MID1,E3 ligase ,TRIM,variable,yes,Multisystem
ENSG00000174010,KLHL15,E3 ligase ,BTB,variable,yes,Brain
ENSG00000124486,USP9X,ubiquitin and UBL proteins,DUB,variable,yes,Brain
ENSG00000182872,RBM10,ubiquitin and UBL binding,mRNA splicing,variable,yes,Heart
ENSG00000130985,UBA1,E1 activating enzymes,nan,core,yes,"Whole Blood, Bone Marrow, Muscle - Skeletal"
ENSG00000094631,HDAC6,ubiquitin and UBL binding,histone deacetylase,variable,yes,"Bone, Brain"
ENSG00000273820,USP27X,Ub and UBL demodifiers,assorted,variable,yes,Brain
ENSG00000086758,HUWE1,E3 ligase ,"Armadillo-like, WW",variable,yes,Brain
ENSG00000188021,UBQLN2,proteasome & associates,UBL,variable,yes,Brain
ENSG00000131263,RLIM,E3 ligase ,other,variable,yes,"Brain, Testis, Ovary"
ENSG00000080561,MID2,E3 ligase ,TRIM,variable,yes,Brain
ENSG00000101901,ALG13,Ub and UBL demodifiers,assorted,variable,yes,Brain
ENSG00000077721,UBE2A,E2 conjugating enzymes,UBC domain only ,variable,yes,Brain
ENSG00000125352,RNF113A,E3 ligase ,other,variable,yes,Multisystem
ENSG00000158290,CUL4B,E3 ligase ,Cullin,variable,yes,Brain
ENSG00000101966,XIAP,E3 ligase ,BIRC / IAP,variable,yes,Whole Blood
ENSG00000269335,IKBKG,ubiquitin and UBL binding,UBAN & NEMO-type ZnF,variable,yes,"Skin, Whole Blood"
ENSG00000114374,USP9Y,ubiquitin and UBL proteins,DUB,variable,yes,Testis