ENSG,Name,Class,Group,Type,Subtype,Gene names,above 5 TPM yes/no,Uniprot swiss ID ENSG00000001629,ANKIB1,E3 ligase ,RBR,"Ariadne, ankyrin repeats, UIM",,"ANKIB1,KIAA1386",yes,Q9P2G1 ENSG00000002746,HECW1,E3 ligase ,HECT,WW & C2,NEDDylation,"HECW1,KIAA0322 NEDL1",yes,Q76N89 ENSG00000003096,KLHL13,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL13,BKLHD2 KIAA1309",yes,Q9P2N7 ENSG00000003756,RBM5,ubiquitin and UBL binding,mRNA maturation,mRNA splicing,RanBP2-type ZnF,"RBM5,",yes,P52756 ENSG00000004534,RBM6,ubiquitin and UBL binding,mRNA maturation,mRNA splicing,RanBP2-type ZnF,"RBM6,DEF3",yes,P78332 ENSG00000004897,CDC27,E3 ligase ,APC,subunit,TPR ,"CDC27,ANAPC3 D0S1430E D17S978E",yes,P30260 ENSG00000005339,CREBBP,ubiquitin and UBL binding,transcription,activation,SIM,"CREBBP,CBP",yes,Q92793 ENSG00000005700,IBTK,E3 ligase ,CRL family,BTB,BTB only / with ankyrin repeats & RCC1,"IBTK,BTKI KIAA1417",yes,Q9P2D0 ENSG00000005810,MYCBP2,E3 ligase ,RING,other,assorted,"MYCBP2,KIAA0916 PAM",yes,O75592 ENSG00000005812,FBXL3,E3 ligase ,CRL family,F-box,LRR,"FBXL3,FBL3A FBXL3A",yes,Q9UKT7 ENSG00000005981,ASB4,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB4,",yes,Q9Y574 ENSG00000006715,VPS41,E3 ligase ,RING,VPS-associated,WD40,"VPS41,",yes,P49754 ENSG00000007047,MARK4,ubiquitin and UBL binding,protein kinases & regulators,microtubule-associated Ser/Thr kinases,UBA,"MARK4,KIAA1860 MARKL1",yes,Q96L34 ENSG00000007168,PAFAH1B1,E3 ligase ,CRL family,DCAF,WD40 / with LisH,"PAFAH1B1,LIS1 MDCR MDS PAFAHA",yes,P43034 ENSG00000007944,MYLIP,E3 ligase ,RING,other,UBL,"MYLIP,BZF1 IDOL",yes,Q8WY64 ENSG00000008018,PSMB1,proteasome & associates,core particle subunit,constitutive,beta subunit,"PSMB1,PSC5",yes,P20618 ENSG00000008382,MPND,Ub and UBL demodifiers,JAMM / MPN,assorted,,"MPND,",yes,Q8N594 ENSG00000008853,RHOBTB2,E3 ligase ,CRL family,BTB,BTB only / with small GTPase,"RHOBTB2,DBC2 KIAA0717",yes,Q9BYZ6 ENSG00000009335,UBE3C,proteasome & associates,associated E3 ligase,HECT,,"UBE3C,KIAA0010 KIAA10",yes,Q15386 ENSG00000010017,RANBP9,E3 ligase ,CTLH complex,subunit,"CRA, LisH, SPRY","RANBP9,RANBPM",yes,Q96S59 ENSG00000010072,SPRTN,p97 and associates,associated non-Ub enzymes,metalloprotease,SHP,"SPRTN,C1orf124 DVC1",yes,Q9H040 ENSG00000011007,ELOA,E3 ligase ,CRL family,F-box,assorted,"ELOA,TCEB3",yes,Q14241 ENSG00000011114,BTBD7,E3 ligase ,CRL family,BTB,with BACK,"BTBD7,KIAA1525",yes,Q9P203 ENSG00000011275,RNF216,E3 ligase ,RBR,assorted,,"RNF216,TRIAD3 UBCE7IP1 ZIN",yes,Q9NWF9 ENSG00000012048,BRCA1,E3 ligase ,RING,BRCA1,,"BRCA1,RNF53",yes,P38398 ENSG00000012963,UBR7,E3 ligase ,RING,UBR,,"UBR7,C14orf130",yes,Q8N806 ENSG00000013275,PSMC4,proteasome & associates,regulatory particle subunit,ATPase,,"PSMC4,MIP224 TBP7",yes,P43686 ENSG00000013374,NUB1,p97 and associates,adaptors,"UBX, VBM, UBL, UBA",,"NUB1,NYREN18",yes,Q9Y5A7 ENSG00000013392,RWDD2A,ubiquitin and UBL binding,assorted processes,RWD domain,,"RWDD2A,RWDD2",yes,Q9UIY3 ENSG00000013561,RNF14,E3 ligase ,RBR,RWD,,"RNF14,ARA54",yes,Q9UBS8 ENSG00000014123,UFL1,E3 ligase ,UBL modifiers,UFMylation,,"UFL1,KIAA0776 MAXER NLBP RCAD",yes,O94874 ENSG00000015153,YAF2,ubiquitin and UBL binding,transcription,coactivation and corepression,RanBP2-type ZnF,"YAF2,",yes,Q8IY57 ENSG00000019995,ZRANB1,Ub and UBL demodifiers,OTU,RanBP2-type ZnF,,"ZRANB1,TRABID",yes,Q9UGI0 ENSG00000020426,MNAT1,E3 ligase ,RING,other,UIM,"MNAT1,CAP35 MAT1 RNF66",yes,P51948 ENSG00000022840,RNF10,E3 ligase ,RING,other,assorted,"RNF10,KIAA0262 RIE2",yes,Q8N5U6 ENSG00000023445,BIRC3,E3 ligase ,RING,BIRC / IAP,BIR repeat,"BIRC3,API2 MIHC RNF49",yes,Q13489 ENSG00000024048,UBR2,proteasome & associates,associated E3 ligase,UBR,,"UBR2,C6orf133 KIAA0349",yes,Q8IWV8 ENSG00000033178,UBA6,E1 activating enzymes,ubiquitylation and FAT10ylation,,,"MOP4 UBE1L2,UBA6",yes,A0AVT1 ENSG00000033800,PIAS1,E3 ligase ,UBL modifiers,sumoylation,MIZ,"PIAS1,DDXBP1",yes,O75925 ENSG00000034677,RNF19A,E3 ligase ,RBR,assorted,,"RNF19A,RNF19",yes,Q9NV58 ENSG00000035928,RFC1,ubiquitin and UBL binding,DNA replication,DNA polymerase clamp loader,MIU,"RFC1,RFC140",yes,P35251 ENSG00000036257,CUL3,E3 ligase ,CRL family,Cullin,,"CUL3,KIAA0617",yes,Q13618 ENSG00000036672,USP2,Ub and UBL demodifiers,USP,assorted,,"USP2,UBP41",yes,O75604 ENSG00000037637,FBXO42,E3 ligase ,CRL family,F-box,KELCH,"FBXO42,FBX42 JFK KIAA1332",yes,Q6P3S6 ENSG00000041357,PSMA4,proteasome & associates,core particle subunit,constitutive,alpha subunit,"PSMA4,HC9 PSC9",yes,P25789 ENSG00000043093,DCUN1D1,E3 ligase ,UBL modifiers,NEDDylation,PONY,"DCUN1D1,DCN1 DCUN1L1 RP42 SCCRO",yes,Q96GG9 ENSG00000043143,JADE2,E3 ligase ,assorted,PHD-type ZnF,,"JADE2,KIAA0239 PHF15",yes,Q9NQC1 ENSG00000044090,CUL7,E3 ligase ,CRL family,Cullin,,"CUL7,KIAA0076",yes,Q14999 ENSG00000046774,MAGEC2,E3 ligase ,RING cofactor,MAGE,,"MAGEC2,HCA587 MAGEE1",yes,Q9UBF1 ENSG00000048028,USP28,Ub and UBL demodifiers,USP,UBA,,"USP28,KIAA1515",yes,Q96RU2 ENSG00000049167,ERCC8,E3 ligase ,CRL family,DCAF,WD40,"ERCC8,CKN1 CSA",yes,Q13216 ENSG00000049759,NEDD4L,E3 ligase ,HECT,WW & C2,NEDDylation,"NEDD4L,KIAA0439 NEDL3",yes,Q96PU5 ENSG00000050730,TNIP3,ubiquitin and UBL binding,NF-kappaB signalling,UBAN,,"TNIP3,ABIN3 LIND",no,Q96KP6 ENSG00000051108,HERPUD1,ubiquitin and UBL proteins,UBL domain,ubiquilin adjacent,,"HERPUD1,HERP KIAA0025 MIF1",yes,Q15011 ENSG00000053900,ANAPC4,E3 ligase ,APC,subunit,WD40,"ANAPC4,APC4",yes,Q9UJX5 ENSG00000055130,CUL1,E3 ligase ,CRL family,Cullin,,"CUL1,",yes,Q13616 ENSG00000055208,TAB2,ubiquitin and UBL binding,NF-kappaB signalling,RanBP2-type ZnF,,"TAB2,KIAA0733 MAP3K7IP2",yes,Q9NYJ8 ENSG00000055483,USP36,Ub and UBL demodifiers,USP,"assorted, large",,"USP36,KIAA1453",yes,Q9P275 ENSG00000056558,TRAF1,E3 ligase ,RING cofactor,TRAF2-specific,MATH/TRAF ,"TRAF1,EBI6",yes,Q13077 ENSG00000056586,RC3H2,E3 ligase ,RING,Roquin,,"RC3H2,MNAB RNF164",yes,Q9HBD1 ENSG00000056972,TRAF3IP2,E3 ligase ,assorted,,,"TRAF3IP2,C6orf2 C6orf4 C6orf5 C6orf6",yes,O43734 ENSG00000058056,USP13,Ub and UBL demodifiers,USP,"UBP-ZnF, UBA",,"USP13,ISOT3",yes,Q92995 ENSG00000059145,UNKL,E3 ligase ,RING,Unkempt,,"UNKL,C16orf28 ZC3H5L ZC3HDC5L",yes,Q9H9P5 ENSG00000060688,SNRNP40,E3 ligase ,CRL family,DCAF,WD40,"SNRNP40,PRP8BP SFP38 WDR57",yes,Q96DI7 ENSG00000061938,TNK2,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,UBA,"TNK2,ACK1",yes,Q07912 ENSG00000062725,APPBP2,E3 ligase ,CRL family,substrate adaptors,non-canonical / with TPR,"APPBP2,KIAA0228 PAT1",yes,Q92624 ENSG00000063978,RNF4,E3 ligase ,RING,other,assorted,"RNF4,SNURF",yes,P78317 ENSG00000064218,DMRT3,ubiquitin and UBL binding,transcription,activation (probable),UBA,"DMRT3,DMRTA3",yes,Q9NQL9 ENSG00000064393,HIPK2,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,SIM,"HIPK2,",yes,Q9H2X6 ENSG00000064726,BTBD1,E3 ligase ,CRL family,BTB,with BACK,"BTBD1,C15orf1 NS5ATP8",yes,Q9H0C5 ENSG00000065717,TLE2,E3 ligase ,CRL family,DCAF,WD40,"TLE2,",yes,Q04725 ENSG00000065802,ASB1,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB1,KIAA1146",yes,Q9Y576 ENSG00000066427,ATXN3,p97 and associates,associated DUBs,Josephin,"VBM, UIM","ATXN3,ATX3 MJD MJD1 SCA3",yes,P54252 ENSG00000068308,OTUD5,Ub and UBL demodifiers,OTU,assorted,,"OTUD5,",yes,Q96G74 ENSG00000068878,PSME4,proteasome & associates,activators and inhibitors ,activator,Armadillo-like,"PSME4,KIAA0077",yes,Q14997 ENSG00000069869,NEDD4,E3 ligase ,HECT,WW & C2,NEDDylation,"NEDD4,KIAA0093 NEDD4-1",yes,P46934 ENSG00000070010,UFD1L,p97 and associates,adaptors,"SHP, UT3",,"UFD1,UFD1L",yes,Q92890 ENSG00000070047,PHRF1,E3 ligase ,RING,other,PHD-type ZnF,"PHRF1,KIAA1542",yes,Q9P1Y6 ENSG00000070423,RNF126,E3 ligase ,RING,other,assorted,"RNF126,",yes,Q9BV68 ENSG00000070950,RAD18,E3 ligase ,RING,SAP,,"RAD18,RNF73",yes,Q9NS91 ENSG00000071794,HLTF,E3 ligase ,RING,other,helicase,"HLTF,HIP116A RNF80 SMARCA3 SNF2L3 ZBU1",yes,Q14527 ENSG00000071894,CPSF1,E3 ligase ,CRL family,CRL adaptor,DDB1,"CPSF1,CPSF160",yes,Q10570 ENSG00000072201,LNX1,E3 ligase ,RING,PDZ,,"LNX1,LNX PDZRN2",yes,Q8TBB1 ENSG00000072401,UBE2D1,E2 conjugating enzymes,ubiquitylation,UBC domain only ,,"UBE2D1,SFT UBC5A UBCH5 UBCH5A",yes,P51668 ENSG00000072422,RHOBTB1,E3 ligase ,CRL family,BTB,BTB only / with small GTPase,"RHOBTB1,KIAA0740",yes,O94844 ENSG00000072518,MARK2,ubiquitin and UBL binding,protein kinases & regulators,microtubule-associated Ser/Thr kinases,UBA,"MARK2,EMK1",yes,Q7KZI7 ENSG00000072609,CHFR,E3 ligase ,RING,other,assorted,"CHFR,RNF196",yes,Q96EP1 ENSG00000072803,FBXW11,E3 ligase ,CRL family,F-box,WD40,"FBXW11,BTRCP2 FBW1B FBXW1B KIAA0696",yes,Q9UKB1 ENSG00000072849,DERL2,p97 and associates,channel proteins,SHP,,"DERL2,DER2 FLANA",yes,Q9GZP9 ENSG00000073536,NLE1,E3 ligase ,CRL family,DCAF,WD40,"NLE1,",yes,Q9NVX2 ENSG00000074266,EED,E3 ligase ,CRL family,DCAF,WD40,"EED,",yes,O75530 ENSG00000075413,MARK3,ubiquitin and UBL binding,protein kinases & regulators,microtubule-associated Ser/Thr kinases,UBA,"MARK3,CTAK1 EMK2",yes,P27448 ENSG00000075975,MKRN2,E3 ligase ,RING,Makorin,,"MKRN2,RNF62",yes,Q9H000 ENSG00000076321,KLHL20,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL20,KLEIP KLHLX",yes,Q9Y2M5 ENSG00000076604,TRAF4,E3 ligase ,RING,"TRAF-type ZnF, MATH/TRAF ",,"TRAF4,CART1 MLN62 RNF83",yes,Q9BUZ4 ENSG00000077152,UBE2T,E2 conjugating enzymes,ubiquitylation,UBC domain & C-terminal extension,,"UBE2T,",yes,Q9NPD8 ENSG00000077254,USP33,Ub and UBL demodifiers,USP,"DUSP, UBP-ZnF",,"USP33,KIAA1097 VDU1",yes,Q8TEY7 ENSG00000077721,UBE2A,E2 conjugating enzymes,ubiquitylation,UBC domain only ,,"UBE2A,RAD6A",yes,P49459 ENSG00000078043,PIAS2,E3 ligase ,UBL modifiers,sumoylation,MIZ,"PIAS2,PIASX",yes,O75928 ENSG00000078140,UBE2K,E2 conjugating enzymes,ubiquitylation,UBC domain & UBA domain,,"UBE2K,HIP2 LIG",yes,P61086 ENSG00000078177,N4BP2,ubiquitin and UBL binding,DNA dependent processes,DNA nicking endonuclease,UBA,"N4BP2,B3BP KIAA1413",yes,Q86UW6 ENSG00000078687,TNRC6C,ubiquitin and UBL binding,translation,repression,UBA,"TNRC6C,KIAA1582",yes,Q9HCJ0 ENSG00000078747,ITCH,E3 ligase ,HECT,WW & C2,ubiquitination,"ITCH,",yes,Q96J02 ENSG00000078967,UBE2D4,E2 conjugating enzymes,ubiquitylation,UBC domain only ,,"UBE2D4,UBCH5D",yes,Q9Y2X8 ENSG00000079387,SENP1,Ub and UBL demodifiers,SENP,deSUMOylase,,"SENP1,",yes,Q9P0U3 ENSG00000079999,KEAP1,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KEAP1,INRF2 KIAA0132 KLHL19",yes,Q14145 ENSG00000080561,MID2,E3 ligase ,RING,TRIM,"COS, FN, SPRY","MID2,FXY2 RNF60 TRIM1",yes,Q9UJV3 ENSG00000080802,CNOT4,E3 ligase ,RING,other,RNA recognition motif,"CNOT4,NOT4",yes,O95628 ENSG00000081087,OSTM1,E3 ligase ,none,none,none,none,yes,none ENSG00000081307,UBA5,E1 activating enzymes,UFMylation,,,"UBE1DC1,UBA5",yes,Q9GZZ9 ENSG00000082438,COBLL1,ubiquitin and UBL proteins,UBL domain,non-enzymes,actin binding ,"COBLL1,KIAA0977",yes,Q53SF7 ENSG00000082512,TRAF5,E3 ligase ,RING,"TRAF-type ZnF, MATH/TRAF ",,"TRAF5,RNF84",yes,O00463 ENSG00000082641,NFE2L1,proteasome & associates,regulators,transcription factor,,"NFE2L1,HBZ17 NRF1 TCF11",yes,Q14494 ENSG00000082996,RNF13,E3 ligase ,RING,Goliath,,"RNF13,RZF",yes,O43567 ENSG00000083544,TDRD3,ubiquitin and UBL binding,transcription,activation,UBA,"TDRD3,",yes,Q9H7E2 ENSG00000083799,CYLD,Ub and UBL demodifiers,USP,CAP Gly-rich domain,,"CYLD,CYLD1 KIAA0849",yes,Q9NQC7 ENSG00000085382,HACE1,E3 ligase ,HECT,ankyrin repeats,,"HACE1,KIAA1320",yes,Q8IYU2 ENSG00000085982,USP40,ubiquitin and UBL proteins,UBL domain,DUB,USP with external UBL,"USP40,",yes,Q9NVE5 ENSG00000086102,NFX1,E3 ligase ,RING,NFX,,"NFX1,NFX2",yes,Q12986 ENSG00000086666,ZFAND6,ubiquitin and UBL binding,with AN1,A20,,"ZFAND6,AWP1 ZA20D3",yes,Q6FIF0 ENSG00000086758,HUWE1,E3 ligase ,HECT,"Armadillo-like, WW",UBA,"HUWE1,KIAA0312 KIAA1578 UREB1",yes,Q7Z6Z7 ENSG00000087152,ATXN7L3,ubiquitin and UBL binding,transcription,activation,SCA7,"ATXN7L3,",yes,Q14CW9 ENSG00000087191,PSMC5,proteasome & associates,regulatory particle subunit,ATPase,,"PSMC5,SUG1",yes,P62195 ENSG00000087206,UIMC1,ubiquitin and UBL binding,E3 ligase cofactor,RAP80 NTD,"UIM, UBZ, SIM","UIMC1,RAP80 RXRIP110",yes,Q96RL1 ENSG00000087338,GMCL1,E3 ligase ,CRL family,BTB,with BACK,"GMCL1,BTBD13 GCL SPATA29",yes,Q96IK5 ENSG00000087448,KLHL42,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL42,KIAA1340 KLHDC5",yes,Q9P2K6 ENSG00000088833,NSFL1C,p97 and associates,adaptors,"UBX, SHP, SEP, UBA",,"NSFL1C,UBXN2C [p47]",yes,Q9UNZ2 ENSG00000089053,ANAPC5,E3 ligase ,APC,subunit,TPR ,"ANAPC5,APC5",yes,Q9UJX4 ENSG00000089094,KDM2B,E3 ligase ,CRL family,F-box,LRR with PHD-type ZnF,"KDM2B,CXXC2 FBL10 FBXL10 JHDM1B NDY1 PCCX2",yes,Q8NHM5 ENSG00000089234,BRAP,E3 ligase ,RING,BRCA1-associated,,"BRAP,RNF52",yes,Q7Z569 ENSG00000089280,FUS,ubiquitin and UBL binding,DNA & RNA dependent processes,DNA/RNA binding protein,RanBP2-type ZnF,"FUS,TLS",yes,P35637 ENSG00000089723,OTUB2,Ub and UBL demodifiers,OTU,assorted,,"OTUB2,C14orf137 OTB2 OTU2",yes,Q96DC9 ENSG00000089902,RCOR1,ubiquitin and UBL binding,transcription,corepression,SIM,"RCOR1,KIAA0071 RCOR",yes,Q9UKL0 ENSG00000090316,MAEA,E3 ligase ,CTLH complex,subunit,"CRA, LisH, RING","MAEA,EMP",yes,Q7L5Y9 ENSG00000090432,MUL1,E3 ligase ,RING,other,assorted,"MUL1,C1orf166 GIDE MAPL MULAN RNF218",yes,Q969V5 ENSG00000090686,USP48,ubiquitin and UBL proteins,UBL domain,DUB,USP with external UBL,"USP48,USP31",yes,Q86UV5 ENSG00000091073,DTX2,E3 ligase ,RING,Deltex,,"DTX2,KIAA1528 RNF58",yes,Q86UW9 ENSG00000091164,TXNL1,proteasome & associates,associated non-Ub enzymes,thioredoxin-like,,"TXNL1,TRP32 TXL TXNL",yes,O43396 ENSG00000091732,ZC3HC1,E3 ligase ,none,none,none,none,yes,none ENSG00000091844,RGS17,ubiquitin and UBL binding,assorted processes,SIM,,"RGS17,RGSZ2",yes,Q9UGC6 ENSG00000092010,PSME1,proteasome & associates,activators and inhibitors ,activator,PA28,"PSME1,IFI5111",yes,Q06323 ENSG00000092098,RNF31,p97 and associates,associated E3 ligases,RBR,"PUB, UBA","RNF31,ZIBRA",yes,Q96EP0 ENSG00000092140,G2E3,E3 ligase ,HECT,PHD-type ZnF,,"G2E3,KIAA1333",yes,Q7L622 ENSG00000092148,HECTD1,E3 ligase ,HECT,"Armadillo-like, ankyrin repeats",,"HECTD1,KIAA1131",yes,Q9ULT8 ENSG00000092470,WDR76,E3 ligase ,CRL family,DCAF,WD40,"WDR76,",yes,Q9H967 ENSG00000092871,RFFL,E3 ligase ,RING,SAP,,"RFFL,RNF189 RNF34L",yes,Q8WZ73 ENSG00000094631,HDAC6,ubiquitin and UBL binding,other protein modifiers,histone deacetylase,UBP-associated ZnF,"HDAC6,KIAA0901",yes,Q9UBN7 ENSG00000094880,CDC23,E3 ligase ,APC,subunit,TPR ,"CDC23,ANAPC8",yes,Q9UJX2 ENSG00000095015,MAP3K1,E3 ligase ,RING,other,"Armadillo-like, SWIM-type ZnF","MAP3K1,MAPKKK1 MEKK MEKK1",yes,Q13233 ENSG00000095261,PSMD5,proteasome & associates,assembly chaperones,regulatory particle,,"PSMD5,KIAA0072",yes,Q16401 ENSG00000099341,PSMD8,proteasome & associates,regulatory particle subunit,nonATPase,PCI,"PSMD8,",yes,P48556 ENSG00000099364,FBXL19,E3 ligase ,CRL family,F-box,LRR with PHD-type ZnF,"FBXL19,FBL19",yes,Q6PCT2 ENSG00000099785,2-Mar,E3 ligase ,RING,MARCH,,"MARCHF2,MARCH2 RNF172",yes,Q9P0N8 ENSG00000099797,TECR,ubiquitin and UBL proteins,UBL domain,assorted enzymes ,enoyl-CoA reductase,"TECR,GPSN2 SC2",yes,Q9NZ01 ENSG00000099804,CDC34,E2 conjugating enzymes,ubiquitylation,UBC domain & C-terminal extension,,"CDC34,UBCH3 UBE2R1",yes,P49427 ENSG00000099910,KLHL22,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL22,",yes,Q53GT1 ENSG00000099949,LZTR1,E3 ligase ,CRL family,BTB,with KELCH ,"LZTR1,TCFL2",yes,Q8N653 ENSG00000099995,SF3A1,ubiquitin and UBL proteins,UBL domain,nucleic acid processes,pre-mRNA splicing,"SF3A1,SAP114",yes,Q15459 ENSG00000099999,RNF215,E3 ligase ,RING,other,assorted,"RNF215,",yes,Q9Y6U7 ENSG00000100023,PPIL2,E3 ligase ,RING,UBOX,,"PPIL2,",yes,Q13356 ENSG00000100221,JOSD1,Ub and UBL demodifiers,Josephin,non-UIM,,"JOSD1,JSPH1 KIAA0063",yes,Q15040 ENSG00000100225,FBXO7,ubiquitin and UBL proteins,UBL domain,E3 ligases,F-box,"FBXO7,FBX7",yes,Q9Y3I1 ENSG00000100263,RHBDD3,ubiquitin and UBL binding,assorted processes,UBA & UIM,,"RHBDD3,C22orf3",yes,Q9Y3P4 ENSG00000100325,ASCC2,ubiquitin and UBL binding,translation ,ribosome QC & DNA repair,UBA,"ASCC2,ASC1P100, RQT3",yes,Q9H1I8 ENSG00000100379,KCTD17,E3 ligase ,CRL family,BTB,KCTD type,"KCTD17,",yes,Q8N5Z5 ENSG00000100387,RBX1,E3 ligase ,CRL family,RBX RING,,"RBX1,RNF75 ROC1",yes,P62877 ENSG00000100418,DESI1,ubiquitin and UBL binding,DUB,PPPDE,SIM,"DESI1,FAM152B PPPDE2",yes,Q6ICB0 ENSG00000100441,KHNYN,ubiquitin and UBL binding,assorted processes,UBA,,"KHNYN,KIAA0323",yes,O15037 ENSG00000100505,TRIM9,E3 ligase ,RING,TRIM,"COS, FN, SPRY","TRIM9,KIAA0282 RNF91",yes,Q9C026 ENSG00000100519,PSMC6,proteasome & associates,regulatory particle subunit,ATPase,,"PSMC6,SUG2",yes,P62333 ENSG00000100532,CGRRF1,E3 ligase ,RING,other,assorted,"CGRRF1,CGR19 RNF197",yes,Q99675 ENSG00000100567,PSMA3,proteasome & associates,core particle subunit,constitutive,alpha subunit,"PSMA3,HC8 PSC8",yes,P25788 ENSG00000100628,ASB2,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB2,",yes,Q96Q27 ENSG00000100764,PSMC1,proteasome & associates,regulatory particle subunit,ATPase,,"PSMC1,",yes,P62191 ENSG00000100804,PSMB5,proteasome & associates,core particle subunit,constitutive,beta subunit,"PSMB5,LMPX MB1 X",yes,P28074 ENSG00000100814,CCNB1IP1,E3 ligase ,RING,other,assorted,"CCNB1IP1,C14orf18 HEI10",yes,Q9NPC3 ENSG00000100897,DCAF11,E3 ligase ,CRL family,DCAF,WD40,"DCAF11,WDR23",yes,Q8TEB1 ENSG00000100902,PSMA6,proteasome & associates,core particle subunit,constitutive,alpha subunit,"PSMA6,PROS27",yes,P60900 ENSG00000100911,PSME2,proteasome & associates,activators and inhibitors ,activator,PA28,"PSME2,",yes,Q9UL46 ENSG00000100991,TRPC4AP,E3 ligase ,CRL family,DCAF,non-WD40,"TRPC4AP,C20orf188 TRRP4AP",yes,Q8TEL6 ENSG00000101182,PSMA7,proteasome & associates,core particle subunit,constitutive,alpha subunit,"PSMA7,HSPC",yes,O14818 ENSG00000101193,GID8,E3 ligase ,CTLH complex,subunit,"CRA, LisH","GID8,C20orf11 TWA1",yes,Q9NWU2 ENSG00000101197,BIRC7,E3 ligase ,RING,BIRC / IAP,BIR repeat,"BIRC7,KIAP LIVIN MLIAP RNF50",yes,Q96CA5 ENSG00000101236,RNF24,E3 ligase ,RING,other,assorted,"RNF24,",yes,Q9Y225 ENSG00000101557,USP14,proteasome & associates,associated DUB,USP,,"USP14,TGT",yes,P54578 ENSG00000101695,RNF125,E3 ligase ,RING,TRAC-1,,"RNF125,",yes,Q96EQ8 ENSG00000101751,POLI,ubiquitin and UBL binding,DNA repair,DNA polymerase,UBM,"POLI,RAD30B",yes,Q9UNA4 ENSG00000101752,MIB1,E3 ligase ,RING,Mindbomb,,"MIB1,DIP1 KIAA1323 ZZANK2",yes,Q86YT6 ENSG00000101782,RIOK3,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,MIU,"RIOK3,SUDD",yes,O14730 ENSG00000101843,PSMD10,proteasome & associates,assembly chaperones,regulatory particle,,"PSMD10,",yes,O75832 ENSG00000101849,TBL1X,E3 ligase ,none,none,none,none,yes,none ENSG00000101871,MID1,E3 ligase ,RING,TRIM,"COS, FN, SPRY","MID1,FXY RNF59 TRIM18 XPRF",yes,O15344 ENSG00000101901,ALG13,Ub and UBL demodifiers,OTU,assorted,,"ALG13,CXorf45 GLT28D1",yes,Q9NP73 ENSG00000101966,XIAP,E3 ligase ,RING,BIRC / IAP,BIR repeat,"XIAP,API3 BIRC4 IAP3",yes,P98170 ENSG00000102048,ASB9,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB9,",yes,Q96DX5 ENSG00000102053,ZC3H12B,ubiquitin and UBL binding,mRNA decay (putative),UBA,,"ZC3H12B,CXorf32 MCPIP2",yes,Q5HYM0 ENSG00000102054,RBBP7,E3 ligase ,CRL family,DCAF,WD40,"RBBP7,RBAP46",yes,Q16576 ENSG00000102128,RAB40AL,E3 ligase ,CRL family,SOCS box,small GTPase,"RAB40AL,RLGP",no,P0C0E4 ENSG00000102178,UBL4A,ubiquitin and UBL proteins,UBL domain,chaperones and related,BAG 6 complex,"UBL4A,DXS254E GDX UBL4",yes,P11441 ENSG00000102226,USP11,ubiquitin and UBL proteins,UBL domain,DUB,USP with internal and external UBL,"USP11,UHX1",yes,P51784 ENSG00000102271,KLHL4,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL4,KIAA1687",yes,Q9C0H6 ENSG00000102471,NDFIP2,E3 ligase ,HECT activator,,,"NDFIP2,KIAA1165 N4WBP5A",yes,Q9NV92 ENSG00000102858,MGRN1,E3 ligase ,RING,other,assorted,"MGRN1,KIAA0544 RNF156",yes,O60291 ENSG00000102921,N4BP1,ubiquitin and UBL binding,assorted processes,UBA,,"N4BP1,KIAA0615",yes,O75113 ENSG00000103035,PSMD7,proteasome & associates,regulatory particle subunit,nonATPase,MPN,"PSMD7,MOV34L",yes,P51665 ENSG00000103091,WDR59,E3 ligase ,CRL family,DCAF,WD40 / with RWD,"WDR59,KIAA1923",yes,Q6PJI9 ENSG00000103194,USP10,Ub and UBL demodifiers,USP,"Ataxin-2, C term",,"USP10,KIAA0190",yes,Q14694 ENSG00000103264,FBXO31,E3 ligase ,CRL family,F-box,only,"FBXO31,FBX14 FBX31",yes,Q5XUX0 ENSG00000103266,STUB1,E3 ligase ,RING,UBOX,,"STUB1,CHIP",yes,Q9UNE7 ENSG00000103275,UBE2I,E2 conjugating enzymes,SUMOylation,,,"UBE2I,UBC9 UBCE9",yes,P63279 ENSG00000103313,MEFV,E3 ligase ,RING,TRIM,"Pyrin, ringless, SPRY","MEFV,MEF TRIM20",yes,O15553 ENSG00000103326,CAPN15,ubiquitin and UBL binding,other proteases,endopeptidase,RanBP2-type ZnF,"CAPN15,SOLH",yes,O75808 ENSG00000103353,UBFD1,ubiquitin and UBL proteins,UBL domain,non-enzymes,assorted ,"UBFD1,UBPH",yes,O14562 ENSG00000103363,ELOB,ubiquitin and UBL proteins,UBL domain,E3 ligases,Elongin B,"ELOB,TCEB2",yes,Q15370 ENSG00000103404,USP31,ubiquitin and UBL proteins,UBL domain,DUB,USP with internal UBL,"USP31,KIAA1203",yes,Q70CQ4 ENSG00000103429,BFAR,E3 ligase ,RING,other,assorted,"BFAR,BAR RNF47",yes,Q9NZS9 ENSG00000103549,RNF40,E3 ligase ,RING,RNF20/40 ish,,"RNF40,BRE1B KIAA0661",yes,O75150 ENSG00000103657,HERC1,E3 ligase ,HECT,RCC1,WD40,"HERC1,",yes,Q15751 ENSG00000103671,TRIP4,ubiquitin and UBL binding,translation ,ribosome QC & transcriptional activation,idiosyncratic,"TRIP4,RQT4",yes,Q15650 ENSG00000104228,TRIM35,E3 ligase ,RING,TRIM,SPRY,"TRIM35,HLS5 KIAA1098",yes,Q9UPQ4 ENSG00000104343,UBE2W,E2 conjugating enzymes,ubiquitylation,UBC domain only ,,"UBE2W,UBC16",yes,Q96B02 ENSG00000104365,IKBKB,ubiquitin and UBL proteins,UBL domain,assorted enzymes ,kinase,"IKBKB,IKKB",yes,O14920 ENSG00000104517,UBR5,E3 ligase ,HECT,RCC1,,"UBR5,EDD EDD1 HYD KIAA0896",yes,O95071 ENSG00000104691,UBXN8,p97 and associates,adaptors,UBX,,"UBXN8,D8S2298E REP8 UBXD6",yes,O00124 ENSG00000104756,KCTD9,E3 ligase ,CRL family,BTB,KCTD type,"KCTD9,",yes,Q7L273 ENSG00000105229,PIAS4,E3 ligase ,UBL modifiers,sumoylation,MIZ,"PIAS4,PIASG",yes,Q8N2W9 ENSG00000105254,TBCB,ubiquitin and UBL proteins,UBL domain,chaperones and related,tubulin-associated,"TBCB,CG22 CKAP1",yes,Q99426 ENSG00000105325,FZR1,E3 ligase ,APC,activator,WD40,"FZR1,CDH1 FYR FZR KIAA1242",yes,Q9UM11 ENSG00000105428,ZNRF4,E3 ligase ,RING,Goliath,,"ZNRF4,RNF204",yes,Q8WWF5 ENSG00000105447,GRWD1,E3 ligase ,CRL family,DCAF,WD40,"GRWD1,GRWD KIAA1942 WDR28",yes,Q9BQ67 ENSG00000105643,ARRDC2,E3 ligase ,HECT adaptor,,,"ARRDC2,",yes,Q8TBH0 ENSG00000105879,CBLL1,E3 ligase ,RING,Hakai,,"CBLL1,HAKAI RNF188",yes,Q75N03 ENSG00000105982,RNF32,E3 ligase ,RING,other,IQ motif,"RNF32,",yes,Q9H0A6 ENSG00000106078,COBL,ubiquitin and UBL proteins,UBL domain,non-enzymes,actin binding ,"COBL,KIAA0633",yes,O75128 ENSG00000106125,MINDY4,Ub and UBL demodifiers,MINDY,,,"MINDY4,C7orf67 FAM188B",yes,Q4G0A6 ENSG00000106336,FBXO24,E3 ligase ,CRL family,F-box,RCC1,"FBXO24,FBX24",yes,O75426 ENSG00000106346,USP42,Ub and UBL demodifiers,USP,"assorted, large",,"USP42,",yes,Q9H9J4 ENSG00000106588,PSMA2,proteasome & associates,core particle subunit,constitutive,alpha subunit,"PSMA2,HC3 PSC3",yes,P25787 ENSG00000106785,TRIM14,E3 ligase ,RING,TRIM,ringless & SPRY,"TRIM14,KIAA0129",yes,Q14142 ENSG00000107262,BAG1,ubiquitin and UBL proteins,UBL domain,chaperones and related,co-chaperone,"BAG1,HAP",yes,Q99933 ENSG00000107341,UBE2R2,E2 conjugating enzymes,ubiquitylation,UBC domain & C-terminal extension,,"UBE2R2,CDC34B UBC3B",yes,Q712K3 ENSG00000107372,ZFAND5,proteasome & associates,adaptors,AN1,A20,"ZFAND5,ZA20D2 ZNF216",yes,O76080 ENSG00000107829,FBXW4,E3 ligase ,CRL family,F-box,WD40,"FBXW4,FBW4 SHFM3",yes,P57775 ENSG00000107872,FBXL15,E3 ligase ,CRL family,F-box,LRR,"FBXL15,FBXO37",yes,Q9H469 ENSG00000107874,CUEDC2,ubiquitin and UBL binding,assorted processes,UBA,,"CUEDC2,C10orf66",yes,Q9H467 ENSG00000107954,NEURL1,E3 ligase ,RING,Neuralized,SPRY / NHR,"NEURL1,NEURL NEURL1A RNF67",yes,O76050 ENSG00000108094,CUL2,E3 ligase ,CRL family,Cullin,,"CUL2,",yes,Q13617 ENSG00000108106,UBE2S,E2 conjugating enzymes,ubiquitylation,UBC domain & C-terminal extension,,"UBE2S,E2EPF",yes,Q16763 ENSG00000108306,FBXL20,E3 ligase ,CRL family,F-box,LRR,"FBXL20,FBL2",yes,Q96IG2 ENSG00000108344,PSMD3,proteasome & associates,regulatory particle subunit,nonATPase,PCI,"PSMD3,",yes,O43242 ENSG00000108375,RNF43,E3 ligase ,RING,other,assorted,"RNF43,",yes,Q68DV7 ENSG00000108395,TRIM37,E3 ligase ,RING,TRIM,MATH/TRAF,"TRIM37,KIAA0898 MUL POB1",yes,O94972 ENSG00000108448,TRIM16L,E3 ligase ,RING,TRIM,ringless & SPRY & folded central helix,"TRIM16L,TRIM70",yes,Q309B1 ENSG00000108465,CDK5RAP3,E3 ligase ,UBL modifiers,UFMylation,,"CDK5RAP3,IC53 LZAP",yes,Q96JB5 ENSG00000108523,RNF167,E3 ligase ,RING,Goliath,,"RNF167,",yes,Q9H6Y7 ENSG00000108671,PSMD11,proteasome & associates,regulatory particle subunit,nonATPase,PCI,"PSMD11,",yes,O00231 ENSG00000108679,LGALS3BP,E3 ligase ,CRL family,BTB,with BACK,"LGALS3BP,M2BP",yes,Q08380 ENSG00000108733,PEX12,E3 ligase ,RING,PEX,,"PEX12,PAF3",yes,O00623 ENSG00000108854,SMURF2,E3 ligase ,HECT,WW & C2,ubiquitination,"SMURF2,",yes,Q9HAU4 ENSG00000109046,WSB1,E3 ligase ,CRL family,SOCS box,WD40,"WSB1,SWIP1",yes,Q9Y6I7 ENSG00000109079,TNFAIP1,E3 ligase ,CRL family,BTB,KCTD type,"TNFAIP1,BACURD2 EDP1",yes,Q13829 ENSG00000109184,DCUN1D4,E3 ligase ,UBL modifiers,NEDDylation,PONY,"DCUN1D4,KIAA0276",yes,Q92564 ENSG00000109189,USP46,Ub and UBL demodifiers,USP,assorted,,"USP46,",yes,P62068 ENSG00000109332,UBE2D3,E2 conjugating enzymes,ubiquitylation,UBC domain only ,,"UBE2D3,UBC5C UBCH5C",yes,P61077 ENSG00000109466,KLHL2,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL2,",yes,O95198 ENSG00000109654,TRIM2,E3 ligase ,RING,TRIM,"FIL, TolB-like","TRIM2,KIAA0517 RNF86",yes,Q9C040 ENSG00000109670,FBXW7,E3 ligase ,CRL family,F-box,WD40,"FBXW7,FBW7 FBX30 SEL10",yes,Q969H0 ENSG00000109674,NEIL3,ubiquitin and UBL binding,DNA repair,DNA glycosylase,RanBP2-type ZnF,"NEIL3,",no,Q8TAT5 ENSG00000109775,UFSP2,Ub and UBL demodifiers,UFSP,deURMylase,,"UFSP2,C4orf20",yes,Q9NUQ7 ENSG00000109790,KLHL5,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL5,",yes,Q96PQ7 ENSG00000110042,DTX4,E3 ligase ,RING,Deltex,,"DTX4,KIAA0937 RNF155",yes,Q9Y2E6 ENSG00000110107,PRPF19,E3 ligase ,RING,UBOX,WD40,"PRPF19,NMP200 PRP19 SNEV",yes,Q9UMS4 ENSG00000110171,TRIM3,E3 ligase ,RING,TRIM,"FIL, TolB-like","TRIM3,BERP RNF22 RNF97",yes,O75382 ENSG00000110200,ANAPC15,E3 ligase ,APC,subunit,assorted ,"ANAPC15,C11orf51",yes,P60006 ENSG00000110315,RNF141,E3 ligase ,RING,other,assorted,"RNF141,ZNF230",yes,Q8WVD5 ENSG00000110330,BIRC2,E3 ligase ,RING,BIRC / IAP,BIR repeat,"BIRC2,API1 MIHB RNF48",yes,Q13490 ENSG00000110344,UBE4A,E3 ligase ,RING,UBOX,,"UBE4A,KIAA0126",yes,Q14139 ENSG00000110395,CBL,E3 ligase ,RING,"CBL, UBA",,"CBL,CBL2 RNF55",yes,P22681 ENSG00000110429,FBXO3,E3 ligase ,CRL family,F-box,assorted,"FBXO3,FBX3",yes,Q9UK99 ENSG00000110497,AMBRA1,E3 ligase ,CRL family,DCAF,WD40,"AMBRA1,DCAF3 KIAA1736",yes,Q9C0C7 ENSG00000110801,PSMD9,proteasome & associates,assembly chaperones,regulatory particle,,"PSMD9,",yes,O00233 ENSG00000110906,KCTD10,E3 ligase ,CRL family,BTB,KCTD type,"KCTD10,ULR061",yes,Q9H3F6 ENSG00000111530,CAND1,E3 ligase ,CRL family,CRL regulator,F-box exchange factor,"CAND1,KIAA0829 TIP120 TIP120A",yes,Q86VP6 ENSG00000111652,COPS7A,Ub and UBL demodifiers,CSN complex,deNEDDylase,,"COPS7A,CSN7A DERP10",yes,Q9UBW8 ENSG00000111665,CDCA3,E3 ligase ,none,none,none,none,yes,none ENSG00000111667,USP5,Ub and UBL demodifiers,USP,"UBP-ZnF, UBA",,"USP5,ISOT",yes,P45974 ENSG00000111671,SPSB2,E3 ligase ,CRL family,SOCS box,SPRY domain,"SPSB2,GRCC9 SSB2",yes,Q99619 ENSG00000111802,TDP2,ubiquitin and UBL binding,DNA repair,5'-tyrosyl DNA phosphodiesterase,UBA,"TDP2,EAP2 TTRAP",yes,O95551 ENSG00000111832,RWDD1,ubiquitin and UBL binding,assorted processes,RWD domain,,"RWDD1,DFRP2",yes,Q9H446 ENSG00000112029,FBXO5,E3 ligase ,CRL family,F-box,assorted,"FBXO5,EMI1 FBX5",yes,Q9UKT4 ENSG00000112078,KCTD20,E3 ligase ,CRL family,BTB,KCTD type,"KCTD20,C6orf69",yes,Q7Z5Y7 ENSG00000112130,RNF8,E3 ligase ,RING,other,assorted,"RNF8,KIAA0646",yes,O76064 ENSG00000112146,FBXO9,E3 ligase ,CRL family,F-box,assorted,"FBXO9,FBX9 VCIA1",yes,Q9UK97 ENSG00000112200,ZNF451,E3 ligase ,UBL modifiers,sumoylation,non-MIZ,"ZNF451,COASTER KIAA0576 KIAA1702",yes,Q9Y4E5 ENSG00000112208,BAG2,proteasome & associates,adaptors,BAG,,"BAG2,",yes,O95816 ENSG00000112234,FBXL4,E3 ligase ,CRL family,F-box,LRR,"FBXL4,FBL4 FBL5",yes,Q9UKA2 ENSG00000112339,HBS1L,ubiquitin and UBL binding,translation ,translation QC factor,UBA,"HBS1L,HBS1 KIAA1038",yes,Q9Y450 ENSG00000112343,TRIM38,E3 ligase ,RING,TRIM,SPRY,"TRIM38,RNF15 RORET",yes,O00635 ENSG00000112659,CUL9,E3 ligase ,CRL family,Cullin,"Armadillo-like, RING","CUL9,H7AP1 KIAA0708 PARC",yes,Q8IWT3 ENSG00000112701,SENP6,Ub and UBL demodifiers,SENP,deSUMOylase,,"SENP6,KIAA0797 SSP1 SUSP1",yes,Q9GZR1 ENSG00000113194,FAF2,p97 and associates,adaptors,"UBX, thioredoxin-like, UBA",,"FAF2,ETEA KIAA0887 UBXD8 UBXN3B",yes,Q96CS3 ENSG00000113269,RNF130,E3 ligase ,RING,Goliath,,"RNF130,",yes,Q86XS8 ENSG00000113369,ARRDC3,E3 ligase ,HECT adaptor,,,"ARRDC3,KIAA1376",yes,Q96B67 ENSG00000113558,SKP1,E3 ligase ,CRL family,CRL adaptor,Skp1,"SKP1,EMC19 OCP2 SKP1A TCEB1L",yes,P63208 ENSG00000113595,TRIM23,E3 ligase ,RING,TRIM,"ARF, P-loop NTP hydrolase","TRIM23,ARD1 ARFD1 RNF46",yes,P36406 ENSG00000113851,CRBN,E3 ligase ,CRL family,DCAF,non-WD40,"CRBN,",yes,Q96SW2 ENSG00000114062,UBE3A,proteasome & associates,associated E3 ligase,HECT,,"UBE3A,E6AP EPVE6AP HPVE6A",yes,Q05086 ENSG00000114098,ARMC8,E3 ligase ,CTLH complex,subunit,Armadillo-like,"ARMC8,",yes,Q8IUR7 ENSG00000114125,RNF7,E3 ligase ,CRL family,RBX RING,,"RNF7,RBX2 ROC2 SAG",yes,Q9UBF6 ENSG00000114316,USP4,ubiquitin and UBL proteins,UBL domain,DUB,USP with internal and external UBL,"USP4,UNP UNPH",yes,Q13107 ENSG00000114374,USP9Y,ubiquitin and UBL proteins,UBL domain,DUB,USP with external UBL,"USP9Y,DFFRY",yes,O00507 ENSG00000114423,CBLB,E3 ligase ,RING,"CBL, UBA",,"CBLB,RNF56",yes,Q13191 ENSG00000114626,ABTB1,E3 ligase ,CRL family,BTB,BTB only / with ankyrin repeats,"ABTB1,BPOZ",yes,Q969K4 ENSG00000114648,KLHL18,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL18,KIAA0795",yes,O94889 ENSG00000114735,HEMK1,ubiquitin and UBL binding,translation ,mitochondrial,UBA,"HEMK1,HEMK",yes,Q9Y5R4 ENSG00000114737,CISH,E3 ligase ,CRL family,SOCS box,SH2 domain,"CISH,G18",yes,Q9NSE2 ENSG00000114742,WDR48,ubiquitin and UBL proteins,UBL domain,DUB modulator,,"WDR48,KIAA1449 UAF1",yes,Q8TAF3 ENSG00000114796,KLHL24,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL24,DRE1",yes,Q6TFL4 ENSG00000115233,PSMD14,proteasome & associates,regulatory particle subunit,nonATPase,MPN,"PSMD14,POH1",yes,O00487 ENSG00000115239,ASB3,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB3,",yes,Q9Y575 ENSG00000115289,PCGF1,ubiquitin and UBL proteins,UBL domain,E3 ligases,RAWUL / polycomb,"PCGF1,NSPC1 RNF68",yes,Q9BSM1 ENSG00000115307,AUP1,ubiquitin and UBL binding,protein quality control,ERAD cofactor,UBA,"AUP1,",yes,Q9Y679 ENSG00000115392,FANCL,E3 ligase ,RING,other,WD40,"FANCL,PHF9",yes,Q9NW38 ENSG00000115464,USP34,ubiquitin and UBL proteins,UBL domain,DUB,USP with external UBL,"USP34,KIAA0570 KIAA0729",yes,Q70CQ2 ENSG00000115760,BIRC6,E2 conjugating enzymes,ubiquitylation,E2-E3 chimera,,"BIRC6,KIAA1289",yes,Q9NR09 ENSG00000115827,DCAF17,E3 ligase ,CRL family,DCAF,non-WD40,"DCAF17,C2orf37",yes,Q5H9S7 ENSG00000116030,SUMO1,ubiquitin and UBL proteins,ubiquitin-like modifier,SUMO,,"SUMO1,SMT3C SMT3H3 UBL1",yes,P63165 ENSG00000116044,NFE2L2,proteasome & associates,regulators,transcription factor,,"NFE2L2,NRF2",yes,Q16236 ENSG00000116141,MARK1,ubiquitin and UBL binding,protein kinases & regulators,microtubule-associated Ser/Thr kinases,UBA,"MARK1,KIAA1477 MARK",yes,Q9P0L2 ENSG00000116161,CACYBP,E3 ligase ,none,none,none,none,yes,none ENSG00000116514,RNF19B,E3 ligase ,RBR,assorted,,"RNF19B,IBRDC3 NKLAM",yes,Q6ZMZ0 ENSG00000116525,TRIM62,E3 ligase ,RING,TRIM,SPRY,"TRIM62,",yes,Q9BVG3 ENSG00000116661,FBXO2,E3 ligase ,CRL family,F-box,FBA,"FBXO2,FBX2",yes,Q9UK22 ENSG00000116663,FBXO6,E3 ligase ,CRL family,F-box,FBA,"FBXO6,FBG2 FBS2 FBX6",yes,Q9NRD1 ENSG00000116679,IVNS1ABP,E3 ligase ,CRL family,BTB,with BACK & KELCH,"IVNS1ABP,ARA3 FLARA3 KIAA0850 KLHL39 NS1 NS1BP",yes,Q9Y6Y0 ENSG00000116750,UCHL5,proteasome & associates,associated DUB,UCH,,"UCHL5,UCH37",yes,Q9Y5K5 ENSG00000117153,KLHL12,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL12,C3IP1",yes,Q53G59 ENSG00000117222,RBBP5,E3 ligase ,CRL family,DCAF,WD40,"RBBP5,RBQ3",yes,Q15291 ENSG00000117399,CDC20,E3 ligase ,APC,activator,WD40,"CDC20,",yes,Q12834 ENSG00000118369,USP35,Ub and UBL demodifiers,USP,Armadillo-type,,"USP35,KIAA1372 USP34",yes,Q9P2H5 ENSG00000118420,UBE3D,E3 ligase ,assorted,,,"UBE3D,C6orf157 H10BH UBE2CBP",no,Q7Z6J8 ENSG00000118496,FBXO30,E3 ligase ,CRL family,F-box,TRAF-type ZnF,"FBXO30,FBX30",yes,Q8TB52 ENSG00000118503,TNFAIP3,E3 ligase ,assorted,with OTU,A20,"TNFAIP3,OTUD7C",yes,P21580 ENSG00000118513,MYB,ubiquitin and UBL binding,transcription,activation,SIM,"MYB,",no,P10242 ENSG00000118518,RNF146,E3 ligase ,RING,Deltex,,"RNF146,",yes,Q9NTX7 ENSG00000118564,FBXL5,E3 ligase ,CRL family,F-box,LRR,"FBXL5,FBL4 FBL5 FLR1",yes,Q9UKA1 ENSG00000118939,UCHL3,Ub and UBL demodifiers,UCH,,,"UCHL3,",yes,P15374 ENSG00000119048,UBE2B,E2 conjugating enzymes,ubiquitylation,UBC domain only ,,"UBE2B,RAD6B",yes,P63146 ENSG00000119231,SENP5,Ub and UBL demodifiers,SENP,deSUMOylase,,"SENP5,",yes,Q96HI0 ENSG00000119283,TRIM67,E3 ligase ,RING,TRIM,"COS, FN, SPRY","TRIM67,TNL",yes,Q6ZTA4 ENSG00000119318,RAD23B,proteasome & associates,adaptors,UBL,with UBA,"RAD23B,",yes,P54727 ENSG00000119401,TRIM32,E3 ligase ,RING,TRIM,TolB-like,"TRIM32,HT2A",yes,Q13049 ENSG00000119402,FBXW2,E3 ligase ,CRL family,F-box,WD40,"FBXW2,FBW2 FWD2",yes,Q9UKT8 ENSG00000119599,DCAF4,E3 ligase ,CRL family,DCAF,WD40,"DCAF4,WDR21 WDR21A",yes,Q8WV16 ENSG00000119669,IRF2BPL,E3 ligase ,RING,IRF2 binding,,"IRF2BPL,C14orf4 EAP1 KIAA1865",yes,Q9H1B7 ENSG00000119682,AREL1,E3 ligase ,HECT,assorted,,"AREL1,KIAA0317",yes,O15033 ENSG00000119771,KLHL29,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL29,KBTBD9 KIAA1921",yes,Q96CT2 ENSG00000119801,YPEL5,E3 ligase ,CTLH complex,subunit,,"YPEL5,",yes,P62699 ENSG00000120686,UFM1,ubiquitin and UBL proteins,ubiquitin-like modifier,UFM1,,"UFM1,C13orf20",yes,P61960 ENSG00000120696,KBTBD7,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KBTBD7,",yes,Q8WVZ9 ENSG00000120833,SOCS2,E3 ligase ,CRL family,SOCS box,SH2 domain,"SOCS2,CIS2 SSI2 STATI2",yes,O14508 ENSG00000120925,RNF170,E3 ligase ,RING,other,assorted,"RNF170,",yes,Q96K19 ENSG00000121022,COPS5,Ub and UBL demodifiers,JAMM / MPN,CSN complex,,"COPS5,CSN5 JAB1",yes,Q92905 ENSG00000121060,TRIM25,E3 ligase ,RING,TRIM,SPRY,"TRIM25,EFP RNF147 ZNF147",yes,Q14258 ENSG00000121067,SPOP,E3 ligase ,CRL family,BTB,BTB only / with MATH/TRAF,"SPOP,",yes,O43791 ENSG00000121236,TRIM6,E3 ligase ,RING,TRIM,SPRY,"TRIM6,RNF89",yes,Q9C030 ENSG00000121440,PDZRN3,E3 ligase ,RING,PDZ,TRAF-type ZnF,"PDZRN3,KIAA1095 LNX3 SEMCAP3",yes,Q9UPQ7 ENSG00000121481,RNF2,ubiquitin and UBL proteins,UBL domain,E3 ligases,RAWUL / polycomb ,"RNF2,BAP1 DING HIPI3 RING1B",yes,Q99496 ENSG00000121741,ZMYM2,ubiquitin and UBL binding,transcription,repression,SIM,"ZMYM2,FIM RAMP ZNF198",yes,Q9UBW7 ENSG00000121988,ZRANB3,ubiquitin and UBL binding,DNA replication,DNE endonuclease and helicase,RanBP2-type ZnF,"ZRANB3,",no,Q5FWF4 ENSG00000122008,POLK,ubiquitin and UBL binding,DNA repair,DNA polymerase,UBZ,"POLK,DINB1",yes,Q9UBT6 ENSG00000122042,UBL3,ubiquitin and UBL proteins,ubiquitin-like modifier,UBL3,,"UBL3,PNSC1",yes,O95164 ENSG00000122257,RBBP6,E3 ligase ,RING,UBOX,,"RBBP6,P2PR PACT RBQ1",yes,Q7Z6E9 ENSG00000122481,RWDD3,ubiquitin and UBL binding,E3 ligase cofactor: SUMOylation,RWD domain,,"RWDD3,RSUME",yes,Q9Y3V2 ENSG00000122550,KLHL7,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL7,",yes,Q8IXQ5 ENSG00000122557,HERPUD2,ubiquitin and UBL proteins,UBL domain,ubiquilin adjacent,,"HERPUD2,",yes,Q9BSE4 ENSG00000122692,SMU1,E3 ligase ,CRL family,DCAF,WD40 / with LisH,"SMU1,",yes,Q2TAY7 ENSG00000122741,DCAF10,E3 ligase ,CRL family,DCAF,WD40,"DCAF10,WDR32",yes,Q5QP82 ENSG00000122779,TRIM24,E3 ligase ,RING,TRIM,"PHD-type ZnF, Bromodomain","TRIM24,RNF82 TIF1 TIF1A",yes,O15164 ENSG00000122877,EGR2,E3 ligase ,assorted,,,"EGR2,KROX20",yes,P11161 ENSG00000123091,RNF11,E3 ligase ,RING,other,assorted,"RNF11,",yes,Q9Y3C5 ENSG00000123124,WWP1,E3 ligase ,HECT,WW & C2,NEDDylation,"WWP1,",yes,Q9H0M0 ENSG00000123297,TSFM,ubiquitin and UBL binding,translation ,mitochondrial,UBA,"TSFM,",yes,P43897 ENSG00000123352,SPATS2,ubiquitin and UBL binding,assorted processes,UBA,,"SPATS2,SCR59 SPATA10",yes,Q86XZ4 ENSG00000123374,CDK2,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,SIM,"CDK2,CDKN2",yes,P24941 ENSG00000123444,KBTBD4,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KBTBD4,BKLHD4",yes,Q9NVX7 ENSG00000123552,USP45,Ub and UBL demodifiers,USP,UBP-ZnF,,"USP45,",yes,Q70EL2 ENSG00000123594,ATXN3L,Ub and UBL demodifiers,Josephin,UIM,,"ATXN3L,ATX3L MJDL",no,Q9H3M9 ENSG00000124217,MOCS3,E1 activating enzymes,URMylation,,,"MOCS3,UBA4",yes,O95396 ENSG00000124226,RNF114,E3 ligase ,RING,TRAC-1,,"RNF114,ZNF228 ZNF313",yes,Q9Y508 ENSG00000124227,ANKRD60,ubiquitin and UBL proteins,UBL domain,non-enzymes,ankyrin repeat,"ANKRD60,C20orf86",yes,Q9BZ19 ENSG00000124257,NEURL2,E3 ligase ,CRL family,SOCS box,NHR,"NEURL2,C20orf163",yes,Q9BR09 ENSG00000124356,STAMBP,Ub and UBL demodifiers,JAMM / MPN,assorted,,"STAMBP,AMSH",yes,O95630 ENSG00000124422,USP22,Ub and UBL demodifiers,USP,UBP-ZnF,,"USP22,KIAA1063 USP3L",yes,Q9UPT9 ENSG00000124486,USP9X,ubiquitin and UBL proteins,UBL domain,DUB,USP with external UBL,"USP9X,DFFRX FAM USP9",yes,Q93008 ENSG00000124535,WRNIP1,ubiquitin and UBL binding,DNA replication,DNA polymerase accessory,UBZ,"WRNIP1,WHIP",yes,Q96S55 ENSG00000124702,KLHDC3,E3 ligase ,CRL family,substrate adaptors,non-canonical / with KELCH,"KLHDC3,PEAS",yes,Q9BQ90 ENSG00000124743,KLHL31,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL31,BKLHD6 KBTBD1 KLHL",yes,Q9H511 ENSG00000124789,NUP153,ubiquitin and UBL binding,NPC subunit,RanBP2-type ZnF,,"NUP153,",yes,P49790 ENSG00000124900,TRIM51,E3 ligase ,RING,TRIM,SPRY - folded central helix,"TRIM51,SPRYD5",no,Q9BSJ1 ENSG00000125352,RNF113A,E3 ligase ,RING,other,assorted,"RNF113A,RNF113 ZNF183",yes,O15541 ENSG00000125818,PSMF1,proteasome & associates,activators and inhibitors ,activator,PI31,"PSMF1,",yes,Q92530 ENSG00000125826,RBCK1,ubiquitin and UBL proteins,UBL domain,E3 ligases,LUBAC complex,"RBCK1,C20orf18 RNF54 UBCE7IP3 XAP3 XAP4",yes,Q9BYM8 ENSG00000126067,PSMB2,proteasome & associates,core particle subunit,constitutive,beta subunit,"PSMB2,",yes,P49721 ENSG00000126107,HECTD3,E3 ligase ,HECT,assorted,,"HECTD3,",yes,Q5T447 ENSG00000126261,UBA2,ubiquitin and UBL proteins,UBL domain,SUMO activation ,,"UBA2,SAE2 UBLE1B",yes,Q9UBT2 ENSG00000127191,TRAF2,E3 ligase ,RING,"TRAF-type ZnF, MATH/TRAF ",,"TRAF2,TRAP3",yes,Q12933 ENSG00000127452,FBXL12,E3 ligase ,CRL family,F-box,LRR,"FBXL12,FBL12",yes,Q9NXK8 ENSG00000127481,UBR4,E3 ligase ,RING,UBR,,"UBR4,KIAA0462 KIAA1307 RBAF600 ZUBR1",yes,Q5T4S7 ENSG00000127585,FBXL16,E3 ligase ,CRL family,F-box,LRR,"FBXL16,C16orf22 FBL16",yes,Q8N461 ENSG00000127870,RNF6,E3 ligase ,RING,other,assorted,"RNF6,SPG2",yes,Q9Y252 ENSG00000127922,SEM1,proteasome & associates,regulatory particle subunit,nonATPase,SEM1,"SEM1,C7orf76 DSS1 SHFDG1 SHFM1",yes,P60896 ENSG00000128250,RFPL1,E3 ligase ,RING,SPRY but not TRIM,,"RFPL1,RFPL1L RNF78",no,O75677 ENSG00000128253,RFPL2,E3 ligase ,RING,SPRY but not TRIM,,"RFPL2,RNF79",yes,O75678 ENSG00000128276,RFPL3,E3 ligase ,RING,SPRY but not TRIM,,"RFPL3,",no,O75679 ENSG00000128482,RNF112,E3 ligase ,RING,other,P-loop NTP hydrolase,"RNF112,BFP ZNF179",yes,Q9ULX5 ENSG00000128585,MKLN1,E3 ligase ,CTLH complex,subunit,"LisH, KELCH","MKLN1,",yes,Q9UL63 ENSG00000128607,KLHDC10,E3 ligase ,CRL family,substrate adaptors,non-canonical / with KELCH,"KLHDC10,KIAA0265",yes,Q6PID8 ENSG00000128731,HERC2,E3 ligase ,HECT,RCC1,,"HERC2,",yes,O95714 ENSG00000128789,PSMG2,proteasome & associates,assembly chaperones,core particle,,"PSMG2,HCCA3 PAC2 TNFSF5IP1",yes,Q969U7 ENSG00000128829,EIF2AK4,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,RWD domain,"EIF2AK4,GCN2 KIAA1338",yes,Q9P2K8 ENSG00000128923,MINDY2,Ub and UBL demodifiers,MINDY,,,"MINDY2,FAM63B KIAA1164",yes,Q8NBR6 ENSG00000129055,ANAPC13,E3 ligase ,APC,subunit,assorted ,"ANAPC13,",yes,Q9BS18 ENSG00000129084,PSMA1,proteasome & associates,core particle subunit,constitutive,alpha subunit,"PSMA1,HC2 NU PROS30 PSC2",yes,P25786 ENSG00000129204,USP6,Ub and UBL demodifiers,USP,Rab-GTPase-TBC,,"USP6,HRP1 TRE2",yes,P35125 ENSG00000129559,NEDD8,ubiquitin and UBL proteins,ubiquitin-like modifier,NEDD8,,"NEDD8,",yes,Q15843 ENSG00000130177,CDC16,E3 ligase ,APC,subunit,TPR ,"CDC16,ANAPC6",yes,Q13042 ENSG00000130311,DDA1,E3 ligase ,CRL family,DCAF,non-WD40,"DDA1,C19orf58 PCIA1",yes,Q9BW61 ENSG00000130338,TULP4,E3 ligase ,CRL family,SOCS box,WD40,"TULP4,KIAA1397 TUBL4 TUSP",yes,Q9NRJ4 ENSG00000130560,UBAC1,ubiquitin and UBL proteins,UBL domain,ubiquitin binding ,UBA,"UBAC1,GBDR1 KPC2 UBADC1",yes,Q9BSL1 ENSG00000130706,ADRM1,proteasome & associates,regulatory particle subunit,nonATPase,"PRU, DEUBAD","ADRM1,GP110",yes,Q16186 ENSG00000130725,UBE2M,E2 conjugating enzymes,NEDDylation,,,"UBE2M,UBC12",yes,P61081 ENSG00000130726,TRIM28,E3 ligase ,RING,TRIM,"PHD-type ZnF, Bromodomain","TRIM28,KAP1 RNF96 TIF1B",yes,Q13263 ENSG00000130939,UBE4B,p97 and associates,associated E3 ligases,RING,VBM,"UBE4B,HDNB1 KIAA0684 UFD2",yes,O95155 ENSG00000130985,UBA1,E1 activating enzymes,ubiquitylation,,,"A1S9T UBE1,UBA1",yes,P22314 ENSG00000131023,LATS1,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,UBA,"LATS1,WARTS",yes,O95835 ENSG00000131263,RLIM,E3 ligase ,RING,other,assorted,"RLIM,RNF12",yes,Q9NVW2 ENSG00000131323,TRAF3,E3 ligase ,RING,"TRAF-type ZnF, MATH/TRAF ",,"TRAF3,CAP1 CRAF1",yes,Q13114 ENSG00000131467,PSME3,proteasome & associates,activators and inhibitors ,activator,PA28,"PSME3,",yes,P61289 ENSG00000131507,NDFIP1,E3 ligase ,HECT activator,,,"NDFIP1,N4WBP5",yes,Q9BT67 ENSG00000131508,UBE2D2,E2 conjugating enzymes,ubiquitylation,UBC domain only ,,"UBE2D2,PUBC1 UBC4 UBC5B UBCH4 UBCH5B",yes,P62837 ENSG00000131653,TRAF7,E3 ligase ,RING,TRAF-type ZnF,WD40,"TRAF7,RFWD1 RNF119",yes,Q6Q0C0 ENSG00000131788,PIAS3,E3 ligase ,UBL modifiers,sumoylation,MIZ,"PIAS3,",yes,Q9Y6X2 ENSG00000131864,USP29,Ub and UBL demodifiers,USP,PH-like,,"USP29,",yes,Q9HBJ7 ENSG00000131871,SELENOS,p97 and associates,adaptors,VIM,,"SELENOS,SELS VIMP",yes,Q9BQE4 ENSG00000132004,FBXW9,E3 ligase ,CRL family,F-box,WD40,"FBXW9,FBW9",yes,Q5XUX1 ENSG00000132017,DCAF15,E3 ligase ,CRL family,DCAF,non-WD40,"DCAF15,C19orf72",yes,Q66K64 ENSG00000132109,TRIM21,E3 ligase ,RING,TRIM,"SPRY, UBOX","TRIM21,RNF81 RO52 SSA1",yes,P19474 ENSG00000132128,LRRC41,E3 ligase ,CRL family,SOCS box,LRR,"LRRC41,MUF1",yes,Q15345 ENSG00000132256,TRIM5,E3 ligase ,RING,TRIM,SPRY,"TRIM5,RNF88",yes,Q9C035 ENSG00000132274,TRIM22,E3 ligase ,RING,TRIM,SPRY,"TRIM22,RNF94 STAF50",yes,Q8IYM9 ENSG00000132356,PRKAA1,ubiquitin and UBL binding,protein kinases & regulators,AMP-activated Ser/Thr kinases,UBA,"PRKAA1,AMPK1",yes,Q13131 ENSG00000132388,UBE2G1,E2 conjugating enzymes,ubiquitylation,UBC domain only,,"UBE2G1,UBE2G",yes,P62253 ENSG00000132478,UNK,E3 ligase ,RING,Unkempt,,"UNK,KIAA1753 ZC3H5 ZC3HDC5",yes,Q9C0B0 ENSG00000132481,TRIM47,E3 ligase ,RING,TRIM,SPRY,"TRIM47,GOA RNF100",yes,Q96LD4 ENSG00000132485,ZRANB2,ubiquitin and UBL binding,mRNA maturation,mRNA splicing,RanBP2-type ZnF,"ZRANB2,ZIS ZNF265",yes,O95218 ENSG00000132640,BTBD3,E3 ligase ,CRL family,BTB,with BACK,"BTBD3,KIAA0952",yes,Q9Y2F9 ENSG00000132716,DCAF8,E3 ligase ,CRL family,DCAF,WD40,"DCAF8,H326 WDR42A",yes,Q5TAQ9 ENSG00000132879,FBXO44,E3 ligase ,CRL family,F-box,FBA,"FBXO44,FBG3 FBX30 FBX44 FBX6A FBXO6A",yes,Q9H4M3 ENSG00000132952,USPL1,Ub and UBL demodifiers,USP,deSUMOylation,,"USPL1,C13orf22 D13S106",yes,Q5W0Q7 ENSG00000132963,POMP,proteasome & associates,assembly chaperones,core particle,,"POMP,C13orf12 UMP1",yes,Q9Y244 ENSG00000132972,RNF17,E3 ligase ,RING,other,assorted,"RNF17,TDRD4",yes,Q9BXT8 ENSG00000133135,RNF128,E3 ligase ,RING,Goliath,,"RNF128,",yes,Q8TEB7 ENSG00000133243,BTBD2,E3 ligase ,CRL family,BTB,with BACK,"BTBD2,",yes,Q9BX70 ENSG00000133606,MKRN1,E3 ligase ,RING,Makorin,,"MKRN1,RNF61",yes,Q9UHC7 ENSG00000133874,RNF122,E3 ligase ,RING,other,assorted,"RNF122,",yes,Q9H9V4 ENSG00000134086,VHL,E3 ligase ,CRL family,VHL,,"VHL,",yes,P40337 ENSG00000134253,TRIM45,E3 ligase ,RING,TRIM,FIL,"TRIM45,RNF99",yes,Q9H8W5 ENSG00000134452,FBXO18,E3 ligase ,CRL family,F-box,assorted,"FBH1,FBX18 FBXO18",yes,Q8NFZ0 ENSG00000134574,DDB2,E3 ligase ,CRL family,DCAF,WD40,"DDB2,",yes,Q92466 ENSG00000134588,USP26,Ub and UBL demodifiers,USP,PH-like,,"USP26,",no,Q9BXU7 ENSG00000134758,RNF138,E3 ligase ,RING,TRAC-1,,"RNF138,NARF",yes,Q8WVD3 ENSG00000134882,UBAC2,ubiquitin and UBL binding,assorted processes,UBA,,"UBAC2,PHGDHL1",yes,Q8NBM4 ENSG00000134899,ERCC5,ubiquitin and UBL binding,DNA repair,DNA endonuclease,UBM,"ERCC5,ERCM2 XPG XPGC",no,P28715 ENSG00000135018,UBQLN1,proteasome & associates,adaptors,UBL,with UBA,"UBQLN1,DA41 PLIC1",yes,Q9UMX0 ENSG00000135063,FAM189A2,E3 ligase ,HECT activator,ITCH-specific,,"ENTREP1,C9orf61 FAM189A2 X123",yes,Q15884 ENSG00000135093,USP30,Ub and UBL demodifiers,USP,assorted,,"USP30,",yes,Q70CQ3 ENSG00000135108,FBXO21,E3 ligase ,CRL family,F-box,assorted,"FBXO21,FBX21 KIAA0875",yes,O94952 ENSG00000135114,OASL,ubiquitin and UBL proteins,UBL domain,nucleic acid processes,double-stranded RNA binding,"OASL,TRIP14",yes,Q15646 ENSG00000135119,RNFT2,E3 ligase ,RING,other,assorted,"RNFT2,TMEM118",yes,Q96EX2 ENSG00000135144,DTX1,E3 ligase ,RING,Deltex,,"DTX1,",yes,Q86Y01 ENSG00000135334,AKIRIN2,proteasome & associates,adaptors,Akirin,,"AKIRIN2,C6orf166",yes,Q53H80 ENSG00000135655,USP15,ubiquitin and UBL proteins,UBL domain,DUB,USP with internal and external UBL,"USP15,KIAA0529",yes,Q9Y4E8 ENSG00000135679,MDM2,E3 ligase ,RING,Mdm,,"MDM2,",yes,Q00987 ENSG00000135686,KLHL36,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL36,C16orf44",yes,Q8N4N3 ENSG00000135722,FBXL8,E3 ligase ,CRL family,F-box,LRR,"FBXL8,FBL8",yes,Q96CD0 ENSG00000135870,RC3H1,E3 ligase ,RING,Roquin,,"RC3H1,KIAA2025 RNF198",yes,Q5TC82 ENSG00000135913,USP37,Ub and UBL demodifiers,USP,"PH-like, UIM",,"USP37,KIAA1594",yes,Q86T82 ENSG00000135924,DNAJB2,ubiquitin and UBL binding,protein quality control,HSP70 cochaperone,UIM,"DNAJB2,HSJ1 HSPF3",yes,P25686 ENSG00000135945,REV1,ubiquitin and UBL binding,DNA repair,dCTP transferase,UBM,"REV1,REV1L",yes,Q9UBZ9 ENSG00000136014,USP44,Ub and UBL demodifiers,USP,UBP-ZnF,,"USP44,",yes,Q9H0E7 ENSG00000136045,PWP1,E3 ligase ,CRL family,DCAF,WD40,"PWP1,",yes,Q13610 ENSG00000136144,RCBTB1,E3 ligase ,CRL family,BTB,BTB only / with RCC1,"RCBTB1,CLLD7 E4.5",yes,Q8NDN9 ENSG00000136161,RCBTB2,E3 ligase ,CRL family,BTB,BTB only / with RCC1,"RCBTB2,CHC1L RLG",yes,O95199 ENSG00000136274,NACAD,ubiquitin and UBL binding,translation ,nascent peptide binding,UBA,"NACAD,KIAA0363",yes,O15069 ENSG00000136485,DCAF7,E3 ligase ,CRL family,DCAF,WD40,"DCAF7,HAN11 WDR68",yes,P61962 ENSG00000136536,7-Mar,E3 ligase ,RING,MARCH,,"MARCHF7,AXOT MARCH7 RNF177",yes,Q9H992 ENSG00000136560,TANK,ubiquitin and UBL binding,DUB cofactor,,UBZ,"TANK,ITRAF TRAF2",yes,Q92844 ENSG00000136636,KCTD3,E3 ligase ,CRL family,BTB,KCTD type (with WD40),"KCTD3,",yes,Q9Y597 ENSG00000136813,KIAA0368,proteasome & associates,activators and inhibitors ,inhibitor,Armadillo-like,"ECPAS,ECM29, KIAA0368",yes,Q5VYK3 ENSG00000136826,KLF4,ubiquitin and UBL binding,transcription,activation and repression,SIM,"KLF4,EZF GKLF",yes,O43474 ENSG00000136878,USP20,Ub and UBL demodifiers,USP,"DUSP, UBP-ZnF",,"USP20,KIAA1003 LSFR3A VDU2",yes,Q9Y2K6 ENSG00000136930,PSMB7,proteasome & associates,core particle subunit,constitutive,beta subunit,"PSMB7,Z",yes,Q99436 ENSG00000136986,DERL1,p97 and associates,channel proteins,SHP,,"DERL1,DER1",yes,Q9BUN8 ENSG00000137055,PLAA,p97 and associates,associated non-Ub enzymes,PLA activator,PUL,"PLAA,PLAP",yes,Q9Y263 ENSG00000137073,UBAP2,ubiquitin and UBL binding,DNA repair,RNA polymerase II removal,UBA,"UBAP2,KIAA1491",yes,Q5T6F2 ENSG00000137075,RNF38,E3 ligase ,RING,other,assorted,"RNF38,",yes,Q9H0F5 ENSG00000137393,RNF144B,E3 ligase ,RBR,assorted,,"RNF144B,IBRDC2 P53RFP",yes,Q7Z419 ENSG00000137522,RNF121,E3 ligase ,RING,other,assorted,"RNF121,",yes,Q9H920 ENSG00000137692,DCUN1D5,E3 ligase ,UBL modifiers,NEDDylation,PONY,"DCUN1D5,SCCRO5",yes,Q9BTE7 ENSG00000137693,YAP1,ubiquitin and UBL binding,transcription,coactivation and corepression,SIM,"YAP1,YAP65",yes,P46937 ENSG00000137699,TRIM29,E3 ligase ,RING,TRIM,ringless & assorted CTD,"TRIM29,ATDC",yes,Q14134 ENSG00000138081,FBXO11,E3 ligase ,CRL family,F-box,"CASH, UBR-type ZnF","FBXO11,FBX11 PRMT9 VIT1",yes,Q86XK2 ENSG00000138100,TRIM54,E3 ligase ,RING,TRIM,COS,"TRIM54,MURF MURF3 RNF30",yes,Q9BYV2 ENSG00000138134,STAMBPL1,Ub and UBL demodifiers,JAMM / MPN,assorted,,"STAMBPL1,AMSHLP KIAA1373",yes,Q96FJ0 ENSG00000138376,BARD1,E3 ligase ,RING,BRCA1-associated,,"BARD1,",yes,Q99728 ENSG00000138411,HECW2,E3 ligase ,HECT,WW & C2,NEDDylation,"HECW2,KIAA1301 NEDL2",yes,Q9P2P5 ENSG00000138442,WDR12,E3 ligase ,CRL family,DCAF,WD40,"WDR12,",yes,Q9GZL7 ENSG00000138468,SENP7,Ub and UBL demodifiers,SENP,deSUMOylase,,"SENP7,KIAA1707 SSP2 SUSP2",yes,Q9BQF6 ENSG00000138592,USP8,Ub and UBL demodifiers,USP,"dimerization, rhodanese-like ",,"USP8,KIAA0055 UBPY",yes,P40818 ENSG00000138629,UBL7,ubiquitin and UBL proteins,UBL domain,ubiquitin binding ,UBA,"UBL7,BMSCUBP",yes,Q96S82 ENSG00000138641,HERC3,E3 ligase ,HECT,RCC1,,"HERC3,KIAA0032",yes,Q15034 ENSG00000138642,HERC6,E3 ligase ,HECT,RCC1,,"HERC6,",yes,Q8IVU3 ENSG00000138646,HERC5,E3 ligase ,HECT,RCC1,,"HERC5,CEB1 CEBP1",yes,Q9UII4 ENSG00000138663,COPS4,Ub and UBL demodifiers,CSN complex,deNEDDylase,,"COPS4,CSN4",yes,Q9BT78 ENSG00000138778,CENPE,ubiquitin and UBL binding,cytoskeletal associated,SIM,,"CENPE,",yes,Q02224 ENSG00000138942,RNF185,E3 ligase ,RING,other,assorted,"RNF185,",yes,Q96GF1 ENSG00000139266,9-Mar,E3 ligase ,RING,MARCH,,"MARCHF9,MARCH9 RNF179",yes,Q86YJ5 ENSG00000139323,POC1B,E3 ligase ,CRL family,DCAF,WD40,"POC1B,WDR51B",yes,Q8TC44 ENSG00000139372,TDG,ubiquitin and UBL binding,DNA repair,DNA glycosylase,SIM,"TDG,",yes,Q13569 ENSG00000139517,LNX2,E3 ligase ,RING,PDZ,,"LNX2,PDZRN1",yes,Q8N448 ENSG00000139797,RNF113B,E3 ligase ,RING,other,assorted,"RNF113B,RNF161 ZNF183L1",yes,Q8IZP6 ENSG00000139842,CUL4A,E3 ligase ,CRL family,Cullin,,"CUL4A,",yes,Q13619 ENSG00000139946,PELI2,E3 ligase ,RING,Pellino,,"PELI2,",yes,Q9HAT8 ENSG00000139990,DCAF5,E3 ligase ,CRL family,DCAF,WD40,"DCAF5,BCRG2 KIAA1824 WDR22",yes,Q96JK2 ENSG00000140332,TLE3,E3 ligase ,CRL family,DCAF,WD40,"TLE3,KIAA1547",yes,Q04726 ENSG00000140367,UBE2Q2,E2 conjugating enzymes,ubiquitylation,UBC domain & RWD-like domain ,,"UBE2Q2,",yes,Q8WVN8 ENSG00000140395,WDR61,E3 ligase ,CRL family,DCAF,WD40,"WDR61,",yes,Q9GZS3 ENSG00000140450,ARRDC4,E3 ligase ,HECT adaptor,,,"ARRDC4,",yes,Q8NCT1 ENSG00000140455,USP3,Ub and UBL demodifiers,USP,UBP-ZnF,,"USP3,",yes,Q9Y6I4 ENSG00000140464,PML,E3 ligase ,RING,TRIM,assorted CTD,"PML,MYL PP8675 RNF71 TRIM19",yes,P29590 ENSG00000140543,DET1,E3 ligase ,CRL family,DCAF,non-WD40,"DET1,",yes,Q7L5Y6 ENSG00000140691,ARMC5,E3 ligase ,CRL family,BTB,BTB only / with Armadillo-like,"ARMC5,",yes,Q96C12 ENSG00000140854,KATNB1,E3 ligase ,CRL family,DCAF,WD40,"KATNB1,",yes,Q9BVA0 ENSG00000141030,COPS3,Ub and UBL demodifiers,CSN complex,deNEDDylase,,"COPS3,CSN3",yes,Q9UNS2 ENSG00000141034,GID4,E3 ligase ,CTLH complex,subunit,,"GID4,C17orf39 VID24",yes,Q8IVV7 ENSG00000141084,RANBP10,E3 ligase ,CTLH complex,subunit,"CRA, LisH, SPRY","RANBP10,KIAA1464",yes,Q6VN20 ENSG00000141542,RAB40B,E3 ligase ,CRL family,SOCS box,small GTPase,"RAB40B,SEC4L",yes,Q12829 ENSG00000141552,ANAPC11,E3 ligase ,APC,subunit,RING,"ANAPC11,",yes,Q9NYG5 ENSG00000141569,TRIM65,E3 ligase ,RING,TRIM,SPRY,"TRIM65,",yes,Q6PJ69 ENSG00000141576,RNF157,E3 ligase ,RING,other,assorted,"RNF157,KIAA1917",yes,Q96PX1 ENSG00000141582,CBX4,E3 ligase ,UBL modifiers,sumoylation,non-MIZ,"CBX4,",yes,O00257 ENSG00000141622,RNF165,E3 ligase ,RING,other,assorted,"RNF165,",yes,Q6ZSG1 ENSG00000141665,FBXO15,E3 ligase ,CRL family,F-box,only,"FBXO15,FBX15",yes,Q8NCQ5 ENSG00000141965,FEM1A,E3 ligase ,CRL family,substrate adaptors,non-canonical / with TPR,"FEM1A,EPRAP",yes,Q9BSK4 ENSG00000142002,DPP9,ubiquitin and UBL binding,other protein modifiers,dipeptidyl peptidase,SIM,"DPP9,DPRP2",yes,Q86TI2 ENSG00000142178,SIK1,ubiquitin and UBL binding,protein kinases & regulators,salt-inducible Ser/Thr kinases,UBA,"SIK1,SIK SNF1LK",yes,P57059 ENSG00000142230,SAE1,E1 activating enzymes,SUMOylation,,,"AOS1 SUA1 UBLE1A,SAE1",yes,Q9UBE0 ENSG00000142273,CBLC,E3 ligase ,RING,CBL,,"CBLC,CBL3 RNF57",yes,Q9ULV8 ENSG00000142507,PSMB6,proteasome & associates,core particle subunit,constitutive,beta subunit,"PSMB6,LMPY Y",yes,P28072 ENSG00000142546,NOSIP,E3 ligase ,RING,UBOX,split UBOX ,"NOSIP,",yes,Q9Y314 ENSG00000142700,DMRTA2,ubiquitin and UBL binding,transcription,DNA binding,UBA,"DMRTA2,DMRT5",no,Q96SC8 ENSG00000142784,WDTC1,E3 ligase ,CRL family,DCAF,WD40 / with TPR,"WDTC1,KIAA1037",yes,Q8N5D0 ENSG00000143106,PSMA5,proteasome & associates,core particle subunit,constitutive,alpha subunit,"PSMA5,",yes,P28066 ENSG00000143164,DCAF6,E3 ligase ,CRL family,DCAF,WD40 / with IQ motif,"DCAF6,IQWD1",yes,Q58WW2 ENSG00000143207,RFWD2,E3 ligase ,CRL family,DCAF,WD40,"COP1,RFWD2 RNF200",yes,Q8NHY2 ENSG00000143222,UFC1,E2 conjugating enzymes,UFMylation,,,"UFC1,",yes,Q9Y3C8 ENSG00000143258,USP21,Ub and UBL demodifiers,USP,assorted,,"USP21,USP23",yes,Q9UK80 ENSG00000143379,SETDB1,ubiquitin and UBL binding,transcription,repression,SIM,"SETDB1,ESET KIAA0067 KMT1E",yes,Q15047 ENSG00000143409,MINDY1,Ub and UBL demodifiers,MINDY,,,"MINDY1,FAM63A KIAA1390",yes,Q8N5J2 ENSG00000143476,DTL,E3 ligase ,CRL family,DCAF,WD40,"DTL,CDT2 CDW1 DCAF2 L2DTL RAMP",yes,Q9NZJ0 ENSG00000143569,UBAP2L,ubiquitin and UBL binding,DNA repair,RNA polymerase II removal,UBA,"UBAP2L,KIAA0144 NICE4",yes,Q14157 ENSG00000143751,SDE2,ubiquitin and UBL proteins,UBL domain,nucleic acid processes,DNA repair,"SDE2,C1orf55",yes,Q6IQ49 ENSG00000143756,FBXO28,E3 ligase ,CRL family,F-box,only,"FBXO28,CENP-30 KIAA0483",yes,Q9NVF7 ENSG00000143947,RPS27A,ubiquitin and UBL proteins,ubiquitin,ribosomal ubiquitin fusion,,"RPS27A,UBA80 UBCEP1",yes,P62979 ENSG00000144010,TRIM43B,E3 ligase ,RING,TRIM,SPRY,"TRIM43B,",no,A6NCK2 ENSG00000144015,TRIM43,E3 ligase ,RING,TRIM,SPRY,"TRIM43,",no,Q96BQ3 ENSG00000144021,CIAO1,E3 ligase ,CRL family,DCAF,WD40,"CIAO1,CIA1 WDR39",yes,O76071 ENSG00000144224,UBXN4,p97 and associates,adaptors,"UBX, thioredoxin-like",,"UBXN4,KIAA0242 UBXD2 UBXDC1",yes,Q92575 ENSG00000144228,SPOPL,E3 ligase ,CRL family,BTB,BTB only / with MATH/TRAF,"SPOPL,",yes,Q6IQ16 ENSG00000144357,UBR3,E3 ligase ,RING,UBR,,"UBR3,KIAA2024 ZNF650",yes,Q6ZT12 ENSG00000144468,RHBDD1,p97 and associates,associated non-Ub enzymes,serine protease,VBM,"RHBDD1,RHBDL4",yes,Q8TEB9 ENSG00000144524,COPS7B,Ub and UBL demodifiers,CSN complex,deNEDDylase,,"COPS7B,CSN7B",yes,Q9H9Q2 ENSG00000144583,4-Mar,E3 ligase ,RING,MARCH,,"MARCHF4,KIAA1399 MARCH4 RNF174",yes,Q9P2E8 ENSG00000144712,CAND2,E3 ligase ,CRL family,CRL regulator,F-box exchange factor,"CAND2,KIAA0667 TIP120B",yes,O75155 ENSG00000144744,UBA3,E1 activating enzymes,NEDDylation,,,"UBE1C,UBA3",yes,Q8TBC4 ENSG00000145041,DCAF1,E3 ligase ,CRL family,DCAF,WD40 / with LisH,"DCAF1,KIAA0800 RIP VPRBP",yes,Q9Y4B6 ENSG00000145332,KLHL8,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL8,KIAA1378",yes,Q9P2G9 ENSG00000145390,USP53,Ub and UBL demodifiers,USP,"assorted, large",,"USP53,KIAA1350",yes,Q70EK8 ENSG00000145416,1-Mar,E3 ligase ,RING,MARCH,,"MARCHF1,MARCH1 RNF171",yes,Q8TCQ1 ENSG00000145428,RNF175,E3 ligase ,RING,other,assorted,"RNF175,",yes,Q8N4F7 ENSG00000145495,6-Mar,E3 ligase ,RING,MARCH,,"MARCHF6,KIAA0597 MARCH6 RNF176 TEB4",yes,O60337 ENSG00000145604,SKP2,E3 ligase ,CRL family,F-box,LRR,"SKP2,FBXL1",yes,Q13309 ENSG00000145743,FBXL17,E3 ligase ,CRL family,F-box,LRR,"FBXL17,FBL17 FBX13 FBXO13",yes,Q9UF56 ENSG00000145780,FEM1C,E3 ligase ,CRL family,substrate adaptors,non-canonical / with TPR,"FEM1C,KIAA1785",yes,Q96JP0 ENSG00000145860,RNF145,E3 ligase ,RING,other,assorted,"RNF145,",yes,Q96MT1 ENSG00000145868,FBXO38,E3 ligase ,CRL family,F-box,LRR,"FBXO38,",yes,Q6PIJ6 ENSG00000145901,TNIP1,ubiquitin and UBL binding,NF-kappaB signalling,UBAN,,"TNIP1,KIAA0113 NAF1",yes,Q15025 ENSG00000145916,RMND5B,E3 ligase ,CTLH complex,subunit,"CRA, LisH, RING","RMND5B,",yes,Q96G75 ENSG00000146021,KLHL3,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL3,KIAA1129",yes,Q9UH77 ENSG00000146054,TRIM7,E3 ligase ,RING,TRIM,SPRY,"TRIM7,GNIP RNF90",yes,Q9C029 ENSG00000146063,TRIM41,E3 ligase ,RING,TRIM,SPRY,"TRIM41,RINCK",yes,Q8WV44 ENSG00000146083,RNF44,E3 ligase ,RING,other,assorted,"RNF44,KIAA1100",yes,Q7L0R7 ENSG00000146247,PHIP,E3 ligase ,CRL family,DCAF,WD40 / with bromodomain,"PHIP,DCAF14 WDR11",yes,Q8WWQ0 ENSG00000146373,RNF217,E3 ligase ,RBR,assorted,,"RNF217,C6orf172 IBRDC1",yes,Q8TC41 ENSG00000146414,SHPRH,E3 ligase ,RING,other,"helicase, PHD-type ZnF","SHPRH,KIAA2023",yes,Q149N8 ENSG00000146755,TRIM50,E3 ligase ,RING,TRIM,SPRY,"TRIM50,TRIM50A",yes,Q86XT4 ENSG00000146776,ATXN7L1,ubiquitin and UBL binding,assorted processes,SCA7,,"ATXN7L1,ATXN7L4 KIAA1218",yes,Q9ULK2 ENSG00000146809,ASB15,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB15,",yes,Q8WXK1 ENSG00000146833,TRIM4,E3 ligase ,RING,TRIM,SPRY,"TRIM4,RNF87",yes,Q9C037 ENSG00000146926,ASB10,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB10,",yes,Q8WXI3 ENSG00000147130,ZMYM3,ubiquitin and UBL binding,cytoskeletal associated,SIM,,"ZMYM3,DXS6673E KIAA0385 ZNF261",yes,Q14202 ENSG00000147364,FBXO25,E3 ligase ,CRL family,F-box,only,"FBXO25,FBX25",yes,Q8TCJ0 ENSG00000147381,MAGEA4,E3 ligase ,RING cofactor,MAGE,,"MAGEA4,MAGE4",yes,P43358 ENSG00000147573,TRIM55,E3 ligase ,RING,TRIM,COS,"TRIM55,MURF2 RNF29",yes,Q9BYV6 ENSG00000147854,UHRF2,ubiquitin and UBL proteins,UBL domain,E3 ligases,DNA repair,"UHRF2,NIRF RNF107",yes,Q96PU4 ENSG00000147912,FBXO10,E3 ligase ,CRL family,F-box,CASH,"FBXO10,FBX10 PRMT11",yes,Q9UK96 ENSG00000148331,ASB6,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB6,",yes,Q9NWX5 ENSG00000148356,LRSAM1,E3 ligase ,RING,other,LRR,"LRSAM1,TAL",yes,Q6UWE0 ENSG00000148481,MINDY3,Ub and UBL demodifiers,MINDY,,,"MINDY3,C10orf97 CARP DERP5 FAM188A",yes,Q9H8M7 ENSG00000148634,HERC4,E3 ligase ,HECT,RCC1,,"HERC4,KIAA1593",yes,Q5GLZ8 ENSG00000148925,BTBD10,E3 ligase ,CRL family,BTB,BTB only (Bioplex only),"BTBD10,GMRP1",yes,Q9BSF8 ENSG00000149243,KLHL35,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL35,",yes,Q6PF15 ENSG00000149289,ZC3H12C,ubiquitin and UBL binding,mRNA decay (putative),UBA,,"ZC3H12C,KIAA1726 MCPIP3",yes,Q9C0D7 ENSG00000149806,FAU,ubiquitin and UBL proteins,ubiquitin-like modifier,FAU,,"FAU,",yes,P35544 ENSG00000150244,TRIM48,E3 ligase ,RING,TRIM,no CTD,"TRIM48,RNF101",no,Q8IWZ4 ENSG00000150361,KLHL1,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL1,KIAA1490",yes,Q9NR64 ENSG00000150401,DCUN1D2,E3 ligase ,UBL modifiers,NEDDylation,PONY,"DCUN1D2,C13orf17 DCUN1L2",yes,Q6PH85 ENSG00000150457,LATS2,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,UBA,"LATS2,KPM",yes,Q9NRM7 ENSG00000150991,UBC,ubiquitin and UBL proteins,ubiquitin,polyubiquitin,,"UBC,",yes,P0CG48 ENSG00000151092,NGLY1,proteasome & associates,regulators,deglycosylase,,"NGLY1,PNG1",yes,Q96IV0 ENSG00000151136,BTBD11,E3 ligase ,CRL family,BTB,BTB only / with ankyrin repeats,"BTBD11,",yes,A6QL63 ENSG00000151148,UBE3B,E3 ligase ,HECT,IQ motif,,"UBE3B,",yes,Q7Z3V4 ENSG00000151692,RNF144A,E3 ligase ,RBR,assorted,,"RNF144A,KIAA0161 RNF144 UBCE7IP4",yes,P50876 ENSG00000151743,AMN1,E3 ligase ,CRL family,SOCS box,LRR,"AMN1,",yes,Q8IY45 ENSG00000151835,SACS,ubiquitin and UBL proteins,UBL domain,chaperones and related,co-chaperone,"SACS,KIAA0730",yes,Q9NZJ4 ENSG00000151876,FBXO4,E3 ligase ,CRL family,F-box,assorted,"FBXO4,FBX4",yes,Q9UKT5 ENSG00000151893,CACUL1,E3 ligase ,CRL family,Cullin,,"CACUL1,C10orf46 CAC1",yes,Q86Y37 ENSG00000152193,RNF219,E3 ligase ,RING,other,assorted,"OBI1,C13orf7 RNF219",yes,Q5W0B1 ENSG00000152422,XRCC4,ubiquitin and UBL binding,DNA repair,DNA repair accessory,SIM,"XRCC4,",yes,Q13426 ENSG00000152484,USP12,Ub and UBL demodifiers,USP,assorted,,"USP12,UBH1 USP12L1",yes,O75317 ENSG00000152503,TRIM36,E3 ligase ,RING,TRIM,"COS, FN, SPRY","TRIM36,RBCC728 RNF98",yes,Q9NQ86 ENSG00000153107,ANAPC1,E3 ligase ,APC,subunit,Armadillo,"ANAPC1,TSG24",yes,Q9H1A4 ENSG00000153201,RANBP2,E3 ligase ,UBL modifiers,sumoylation,non-MIZ,"RANBP2,NUP358",yes,P49792 ENSG00000153443,UBALD1,ubiquitin and UBL binding,assorted processes,UBA,,"UBALD1,FAM100A",yes,Q8TB05 ENSG00000153558,FBXL2,E3 ligase ,CRL family,F-box,LRR,"FBXL2,FBL2 FBL3",yes,Q9UKC9 ENSG00000153561,RMND5A,E3 ligase ,CTLH complex,subunit,"CRA, LisH, RING","RMND5A,",yes,Q9H871 ENSG00000153827,TRIP12,proteasome & associates,associated E3 ligase,HECT,,"TRIP12,KIAA0045 ULF",yes,Q14669 ENSG00000153832,FBXO36,E3 ligase ,CRL family,F-box,only,"FBXO36,FBX36",yes,Q8NEA4 ENSG00000153975,ZUFSP,Ub and UBL demodifiers,UFSP,DUB,,"ZUP1,C6orf113 ZUFSP",yes,Q96AP4 ENSG00000154007,ASB17,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB17,",yes,Q8WXJ9 ENSG00000154059,IMPACT,ubiquitin and UBL binding,translation ,translational upregulation,RWD domain,"IMPACT,",yes,Q9P2X3 ENSG00000154114,TBCEL,ubiquitin and UBL proteins,UBL domain,chaperones and related,tubulin-associated,"TBCEL,LRRC35",yes,Q5QJ74 ENSG00000154124,OTULIN,Ub and UBL demodifiers,OTU,assorted,,"OTULIN,FAM105B",yes,Q96BN8 ENSG00000154127,UBASH3B,ubiquitin and UBL binding,protein phosphatases,Tyr phosphatase,UBA,"UBASH3B,KIAA1959 STS1",yes,Q8TF42 ENSG00000154277,UCHL1,Ub and UBL demodifiers,UCH,,,"UCHL1,",yes,P09936 ENSG00000154359,LONRF1,E3 ligase ,RING,LON,TPR,"LONRF1,RNF191",yes,Q17RB8 ENSG00000154370,TRIM11,E3 ligase ,RING,TRIM,SPRY,"TRIM11,RNF92",yes,Q96F44 ENSG00000154447,SH3RF1,E3 ligase ,RING,SH3,,"SH3RF1,KIAA1494 POSH POSH1 RNF142 SH3MD2",yes,Q7Z6J0 ENSG00000154493,C10orf90,E3 ligase ,assorted,,,"C10orf90,FATS",yes,Q96M02 ENSG00000154582,ELOC,E3 ligase ,CRL family,CRL adaptor,Elongin BC,"ELOC,TCEB1",yes,Q15369 ENSG00000154611,PSMA8,proteasome & associates,core particle subunit,specialized,alpha subunit,"PSMA8,PSMA7L",yes,Q8TAA3 ENSG00000154914,USP43,ubiquitin and UBL proteins,UBL domain,DUB,USP with internal UBL,"USP43,",yes,Q70EL4 ENSG00000155034,FBXL18,E3 ligase ,CRL family,F-box,LRR,"FBXL18,FBL18",yes,Q96ME1 ENSG00000155100,OTUD6B,Ub and UBL demodifiers,OTU,assorted,,"OTUD6B,DUBA5",yes,Q8N6M0 ENSG00000155313,USP25,Ub and UBL demodifiers,USP,"UBA, UIM",,"USP25,USP21",yes,Q9UHP3 ENSG00000155428,TRIM74,E3 ligase ,RING,TRIM,no CTD,"TRIM74,TRIM50C",yes,Q86UV6 ENSG00000155827,RNF20,E3 ligase ,RING,RNF20/40 ish,,"RNF20,BRE1A",yes,Q5VTR2 ENSG00000155890,TRIM42,E3 ligase ,RING,TRIM,"COS, FN ","TRIM42,",yes,Q8IWZ5 ENSG00000156253,RWDD2B,ubiquitin and UBL binding,assorted processes,RWD domain,,"RWDD2B,C21orf6",yes,P57060 ENSG00000156256,USP16,Ub and UBL demodifiers,USP,UBP-ZnF,,"USP16,",yes,Q9Y5T5 ENSG00000156374,PCGF6,ubiquitin and UBL proteins,UBL domain,E3 ligases,RAWUL / polycomb ,"PCGF6,MBLR RNF134",yes,Q9BYE7 ENSG00000156381,ANKRD9,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ANKRD9,",yes,Q96BM1 ENSG00000156463,SH3RF2,E3 ligase ,RING,SH3,,"SH3RF2,POSH3 POSHER PPP1R39 RNF158",yes,Q8TEC5 ENSG00000156509,FBXO43,E3 ligase ,CRL family,F-box,assorted,"FBXO43,EMI2",yes,Q4G163 ENSG00000156587,UBE2L6,E2 conjugating enzymes,ubiquitylation and ISG15ylation,UBC domain only,,"UBE2L6,UBCH8",yes,O14933 ENSG00000156639,ZFAND3,ubiquitin and UBL binding,with AN1,A20,,"ZFAND3,TEX27",yes,Q9H8U3 ENSG00000156804,FBXO32,E3 ligase ,CRL family,F-box,only,"FBXO32,",yes,Q969P5 ENSG00000156831,NSMCE2,E3 ligase ,UBL modifiers,sumoylation,MIZ,"NSMCE2,C8orf36 MMS21",yes,Q96MF7 ENSG00000156931,VPS8,E3 ligase ,RING,VPS-associated,WD40,"VPS8,KIAA0804",yes,Q8N3P4 ENSG00000157119,KLHL40,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL40,KBTBD5 SRYP",yes,Q2TBA0 ENSG00000157450,RNF111,E3 ligase ,RING,other,assorted,"RNF111,",yes,Q6ZNA4 ENSG00000157625,TAB3,ubiquitin and UBL binding,NF-kappaB signalling,RanBP2-type ZnF,,"TAB3,MAP3K7IP3",yes,Q8N5C8 ENSG00000157778,PSMG3,proteasome & associates,assembly chaperones,core particle,,"PSMG3,C7orf48 PAC3",yes,Q9BT73 ENSG00000157911,PEX10,E3 ligase ,RING,PEX,,"PEX10,RNF69",yes,O60683 ENSG00000157999,ANKRD61,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ANKRD61,",yes,A6NGH8 ENSG00000158019,BRE,E3 ligase ,RING cofactor,BRCA1-specific,,"BABAM2,BRCC45 BRE",yes,Q9NXR7 ENSG00000158022,TRIM63,E3 ligase ,RING,TRIM,COS,"TRIM63,IRF MURF1 RNF28 SMRZ",yes,Q969Q1 ENSG00000158062,UBXN11,p97 and associates,adaptors,"UBX, SHP, SEP",,"UBXN11,SOC UBXD5",yes,Q5T124 ENSG00000158286,RNF207,E3 ligase ,RING,TRIM,assorted CTD,"RNF207,C1orf188",yes,Q6ZRF8 ENSG00000158290,CUL4B,E3 ligase ,CRL family,Cullin,,"CUL4B,KIAA0695",yes,Q13620 ENSG00000158552,ZFAND2B,proteasome & associates,adaptors,AN1,UIM,"ZFAND2B,AIRAPL",yes,Q8WV99 ENSG00000158717,RNF166,E3 ligase ,RING,TRAC-1,,"RNF166,",yes,Q96A37 ENSG00000159069,FBXW5,E3 ligase ,CRL family,F-box,WD40,"FBXW5,FBW5",yes,Q969U6 ENSG00000159202,UBE2Z,E2 conjugating enzymes,FAT10ylation,UBC domain & N-terminal and C-terminal extensions,,"UBE2Z,",yes,Q9H832 ENSG00000159352,PSMD4,proteasome & associates,regulatory particle subunit,nonATPase,"VWA, UIM","PSMD4,MCB1",yes,P55036 ENSG00000159377,PSMB4,proteasome & associates,core particle subunit,constitutive,beta subunit,"PSMB4,PROS26",yes,P28070 ENSG00000159459,UBR1,proteasome & associates,associated E3 ligase,UBR,,"UBR1,",yes,Q8IWV7 ENSG00000159461,AMFR,p97 and associates,associated E3 ligases,UBOX,VIM,"AMFR,RNF45",yes,Q9UKV5 ENSG00000159579,RSPRY1,E3 ligase ,RING,SPRY but not TRIM,,"RSPRY1,KIAA1972",yes,Q96DX4 ENSG00000159593,NAE1,E1 activating enzymes,NEDDylation,,,"APPBP1,NAE1",yes,Q13564 ENSG00000160087,UBE2J2,E2 conjugating enzymes,ubiquitylation,UBC domain & transmembrane domain,,"UBE2J2,NCUBE2",yes,Q8N2K1 ENSG00000160185,UBASH3A,ubiquitin and UBL binding,protein phosphatases,Tyr phosphatase,UBA,"UBASH3A,STS2",yes,P57075 ENSG00000160226,C21orf2,E3 ligase ,CTLH complex,subunit,LRR,"CFAP410,C21orf2 LRRC76",yes,O43822 ENSG00000160410,SHKBP1,E3 ligase ,CRL family,BTB,KCTD type (with WD40),"SHKBP1,SB1",yes,Q8TBC3 ENSG00000160445,ZER1,E3 ligase ,CRL family,substrate adaptors,"non-canonical / with TPR, Armadillo-like","ZER1,C9orf60 ZYG ZYG11BL",yes,Q7Z7L7 ENSG00000160469,BRSK1,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,UBA,"BRSK1,KIAA1811 SAD1 SADB",yes,Q8TDC3 ENSG00000160584,SIK3,ubiquitin and UBL binding,protein kinases & regulators,salt-inducible Ser/Thr kinases,UBA,"SIK3,KIAA0999 QSK",yes,Q9Y2K2 ENSG00000160695,VPS11,E3 ligase ,RING,VPS-associated,WD40,"VPS11,RNF108",yes,Q9H270 ENSG00000160714,UBE2Q1,E2 conjugating enzymes,ubiquitylation,UBC domain & RWD-like domain ,,"UBE2Q1,NICE5 UBE2Q",yes,Q7Z7E8 ENSG00000160803,UBQLN4,proteasome & associates,adaptors,UBL,with UBA,"UBQLN4,C1orf6 CIP75 UBIN",yes,Q9NRR5 ENSG00000161011,SQSTM1,proteasome & associates,adaptors,PB1,UBA,"SQSTM1,ORCA OSIL",yes,Q13501 ENSG00000161040,FBXL13,E3 ligase ,CRL family,F-box,LRR,"FBXL13,DRC6 FBL13",yes,Q8NEE6 ENSG00000161057,PSMC2,proteasome & associates,regulatory particle subunit,ATPase,,"PSMC2,MSS1",yes,P35998 ENSG00000161243,FBXO27,E3 ligase ,CRL family,F-box,FBA,"FBXO27,FBG5 FBX27",yes,Q8NI29 ENSG00000161594,KLHL10,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL10,",yes,Q6JEL2 ENSG00000161664,ASB16,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB16,",yes,Q96NS5 ENSG00000161677,JOSD2,Ub and UBL demodifiers,Josephin,non-UIM,,"JOSD2,",yes,Q8TAC2 ENSG00000161956,SENP3,Ub and UBL demodifiers,SENP,deSUMOylase,,"SENP3,SSP3 SUSP3",yes,Q9H4L4 ENSG00000161981,SNRNP25,ubiquitin and UBL proteins,UBL domain,nucleic acid processes,mRNA splicing,"SNRNP25,C16orf33",yes,Q9BV90 ENSG00000162032,SPSB3,E3 ligase ,CRL family,SOCS box,SPRY domain,"SPSB3,C16orf31 SSB3",yes,Q6PJ21 ENSG00000162063,CCNF,E3 ligase ,CRL family,F-box,assorted,"CCNF,FBX1 FBXO1",yes,P41002 ENSG00000162191,UBXN1,p97 and associates,adaptors,"UBX, UBA",,"UBXN1,SAKS1",yes,Q04323 ENSG00000162231,NXF1,ubiquitin and UBL binding,mRNA export,UBA,,"NXF1,TAP",yes,Q9UBU9 ENSG00000162298,SYVN1,p97 and associates,associated E3 ligases,RING,VBM,"SYVN1,HRD1 KIAA1810",yes,Q86TM6 ENSG00000162378,ZYG11B,E3 ligase ,CRL family,substrate adaptors,"non-canonical / with TPR, Armadillo-like","ZYG11B,KIAA1730",yes,Q9C0D3 ENSG00000162402,USP24,ubiquitin and UBL proteins,UBL domain,DUB,USP with external UBL,"USP24,KIAA1057",yes,Q9UPU5 ENSG00000162409,PRKAA2,ubiquitin and UBL binding,protein kinases & regulators,AMP-activated Ser/Thr kinases,UBA,"PRKAA2,AMPK AMPK2",yes,P54646 ENSG00000162413,KLHL21,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL21,KIAA0469",yes,Q9UJP4 ENSG00000162521,RBBP4,E3 ligase ,CRL family,DCAF,WD40,"RBBP4,RBAP48",yes,Q09028 ENSG00000162543,UBXN10,p97 and associates,adaptors,UBX,,"UBXN10,UBXD3",yes,Q96LJ8 ENSG00000162585,FAAP20,ubiquitin and UBL binding,DNA repair,DNA repair accessory,UBZ,"FAAP20,C1orf86",yes,Q6NZ36 ENSG00000162601,MYSM1,Ub and UBL demodifiers,JAMM / MPN,assorted,,"MYSM1,KIAA1915",yes,Q5VVJ2 ENSG00000162607,USP1,Ub and UBL demodifiers,USP,assorted,,"USP1,",yes,O94782 ENSG00000162650,ATXN7L2,ubiquitin and UBL binding,assorted processes,SCA7,,"ATXN7L2,",yes,Q5T6C5 ENSG00000162722,TRIM58,E3 ligase ,RING,TRIM,SPRY,"TRIM58,",yes,Q8NG06 ENSG00000162923,WDR26,E3 ligase ,CTLH complex,subunit,"LisH, WD40","WDR26,CDW2 MIP2",yes,Q9H7D7 ENSG00000162931,TRIM17,E3 ligase ,RING,TRIM,SPRY,"TRIM17,RBCC RNF16 TERF",yes,Q9Y577 ENSG00000163012,ZSWIM2,E3 ligase ,RING,other,SWIM-type ZnF,"ZSWIM2,ZZZ2",yes,Q8NEG5 ENSG00000163013,FBXO41,E3 ligase ,CRL family,F-box,LRR,"FBXO41,FBX41 KIAA1940",yes,Q8TF61 ENSG00000163098,BIRC8,E3 ligase ,RING,BIRC / IAP,BIR repeat,"BIRC8,ILP2",yes,Q96P09 ENSG00000163104,SMARCAD1,ubiquitin and UBL binding,DNA dependent processes,chromatin remodeling,UBA,"SMARCAD1,KIAA1122",yes,Q9H4L7 ENSG00000163121,NEURL3,E3 ligase ,RING,Neuralized,SPRY / NHR,"NEURL3,LINCR",yes,Q96EH8 ENSG00000163162,RNF149,E3 ligase ,RING,Goliath,,"RNF149,DNAPTP2",yes,Q8NC42 ENSG00000163214,DHX57,ubiquitin and UBL binding,assorted processes,"UBA, RWD domain",,"DHX57,",yes,Q6P158 ENSG00000163257,DCAF16,E3 ligase ,CRL family,DCAF,non-WD40,"DCAF16,C4orf30",yes,Q9NXF7 ENSG00000163357,DCST1,E3 ligase ,RING,other,assorted,"DCST1,",yes,Q5T197 ENSG00000163376,KBTBD8,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KBTBD8,KIAA1842 TAKRP",yes,Q8NFY9 ENSG00000163444,TMEM183A,E3 ligase ,CRL family,F-box,transmembrane,"TMEM183A,C1orf37",yes,Q8IXX5 ENSG00000163462,TRIM46,E3 ligase ,RING,TRIM,"COS, FN, SPRY","TRIM46,TRIFIC",yes,Q7Z4K8 ENSG00000163481,RNF25,E3 ligase ,RING,other,RWD,"RNF25,",yes,Q96BH1 ENSG00000163516,ANKZF1,p97 and associates,adaptors,"VIM, ankyrin repeats",,"ANKZF1,ZNF744",yes,Q9H8Y5 ENSG00000163602,RYBP,ubiquitin and UBL binding,transcription,repression,RanBP2-type ZnF,"RYBP,DEDAF YEAF1",yes,Q8N488 ENSG00000163635,ATXN7,ubiquitin and UBL binding,transcription,activation,SCA7,"ATXN7,SCA7",yes,O15265 ENSG00000163636,PSMD6,proteasome & associates,regulatory particle subunit,nonATPase,PCI,"PSMD6,KIAA0107 PFAAP4",yes,Q15008 ENSG00000163743,RCHY1,E3 ligase ,RING,other,assorted,"RCHY1,ARNIP CHIMP PIRH2 RNF199 ZNF363",yes,Q96PM5 ENSG00000163788,SNRK,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,UBA,"SNRK,KIAA0096 SNFRK",yes,Q9NRH2 ENSG00000163833,FBXO40,E3 ligase ,CRL family,F-box,TRAF-type ZnF,"FBXO40,FBX40 KIAA1195",yes,Q9UH90 ENSG00000163840,DTX3L,E3 ligase ,RING,Deltex,,"DTX3L,BBAP",yes,Q8TDB6 ENSG00000163874,ZC3H12A,ubiquitin and UBL binding,mRNA decay,UBA,,"ZC3H12A,MCPIP MCPIP1",yes,Q5D1E8 ENSG00000163904,SENP2,Ub and UBL demodifiers,SENP,deSUMOylase,,"SENP2,KIAA1331",yes,Q9HC62 ENSG00000163930,BAP1,Ub and UBL demodifiers,UCH,,,"BAP1,KIAA0272",yes,Q92560 ENSG00000163960,UBXN7,p97 and associates,adaptors,"UBX, thioredoxin-like, UBA",,"UBXN7,KIAA0794 UBXD7",yes,O94888 ENSG00000163961,RNF168,E3 ligase ,RING,other,assorted,"RNF168,",yes,Q8IYW5 ENSG00000164049,FBXW12,E3 ligase ,CRL family,F-box,WD40,"FBXW12,FBW12 FBXO12 FBXO35",no,Q6X9E4 ENSG00000164068,RNF123,E3 ligase ,RING,SPRY but not TRIM,,"RNF123,KPC1",yes,Q5XPI4 ENSG00000164091,WDR82,E3 ligase ,CRL family,DCAF,WD40,"WDR82,TMEM113 WDR82A",yes,Q6UXN9 ENSG00000164117,FBXO8,E3 ligase ,CRL family,F-box,assorted,"FBXO8,FBS FBX8",yes,Q9NRD0 ENSG00000164122,ASB5,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB5,",yes,Q8WWX0 ENSG00000164162,ANAPC10,E3 ligase ,APC,subunit,DOC,"ANAPC10,APC10",yes,Q9UM13 ENSG00000164164,OTUD4,Ub and UBL demodifiers,OTU,assorted,,"OTUD4,HIN-1 KIAA1046",yes,Q01804 ENSG00000164197,RNF180,E3 ligase ,RING,other,assorted,"RNF180,",yes,Q86T96 ENSG00000164287,CDC20B,E3 ligase ,APC,activator,WD40,"CDC20B,",yes,Q86Y33 ENSG00000164292,RHOBTB3,E3 ligase ,CRL family,BTB,BTB only / with small GTPase,"RHOBTB3,KIAA0878",yes,O94955 ENSG00000164309,CMYA5,E3 ligase ,RING,TRIM,ringless & FN & SPRY,"CMYA5,C5orf10 DTNBP2 SPRYD2 TRIM76",yes,Q8N3K9 ENSG00000164332,UBLCP1,ubiquitin and UBL proteins,UBL domain,assorted enzymes ,proteasome phosphatase,"UBLCP1,",yes,Q8WVY7 ENSG00000164663,USP49,Ub and UBL demodifiers,USP,UBP-ZnF,,"USP49,",yes,Q70CQ1 ENSG00000164675,IQUB,ubiquitin and UBL proteins,UBL domain,non-enzymes,assorted ,"IQUB,",yes,Q8NA54 ENSG00000164751,PEX2,E3 ligase ,RING,PEX,,"PEX2,PAF1 PMP3 PMP35 PXMP3 RNF72",yes,P28328 ENSG00000164897,TMUB1,ubiquitin and UBL proteins,UBL domain,non-enzymes,transmembrane,"TMUB1,C7orf21 DULP HOPS",yes,Q9BVT8 ENSG00000164934,DCAF13,E3 ligase ,CRL family,DCAF,WD40,"DCAF13,WDSOF1",yes,Q9NV06 ENSG00000165188,RNF183,E3 ligase ,RING,other,assorted,"RNF183,",yes,Q96D59 ENSG00000165192,ASB11,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB11,",yes,Q8WXH4 ENSG00000165280,VCP,p97 and associates,p97,,,"VCP,",yes,P55072 ENSG00000165312,OTUD1,Ub and UBL demodifiers,OTU,assorted,,"OTUD1,DUBA7 OTDC1",yes,Q5VV17 ENSG00000165338,HECTD2,E3 ligase ,HECT,assorted,,"HECTD2,",yes,Q5U5R9 ENSG00000165355,FBXO33,E3 ligase ,CRL family,F-box,LRR,"FBXO33,FBX33",yes,Q7Z6M2 ENSG00000165406,8-Mar,E3 ligase ,RING,MARCH,,"MARCHF8,MARCH8 MIR RNF178",yes,Q5T0T0 ENSG00000165501,LRR1,E3 ligase ,CRL family,substrate adaptors,non-canonical / with TPR,"LRR1,PPIL5",yes,Q96L50 ENSG00000165516,KLHDC2,E3 ligase ,CRL family,substrate adaptors,non-canonical / with KELCH,"KLHDC2,HCA33",yes,Q9Y2U9 ENSG00000165572,KBTBD6,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KBTBD6,",yes,Q86V97 ENSG00000165886,UBTD1,ubiquitin and UBL proteins,UBL domain,non-enzymes,assorted ,"UBTD1,",yes,Q9HAC8 ENSG00000165916,PSMC3,proteasome & associates,regulatory particle subunit,ATPase,,"PSMC3,TBP1",yes,P17980 ENSG00000165917,RAPSN,E3 ligase ,RING,other,TPR,"RAPSN,RNF205",yes,Q13702 ENSG00000165966,PDZRN4,E3 ligase ,RING,PDZ,,"PDZRN4,LNX4 SEMCAP3L",yes,Q6ZMN7 ENSG00000166016,ABTB2,E3 ligase ,CRL family,BTB,BTB only / with ankyrin repeats,"ABTB2,",yes,Q8N961 ENSG00000166167,BTRC,E3 ligase ,CRL family,F-box,WD40,"BTRC,BTRCP FBW1A FBXW1A",yes,Q9Y297 ENSG00000166192,SENP8,Ub and UBL demodifiers,SENP,"deNEDDylase, NEDD8 processing",,"SENP8,DEN1 NEDP1 PRSC2",yes,Q96LD8 ENSG00000166200,COPS2,Ub and UBL demodifiers,CSN complex,deNEDDylase,,"COPS2,CSN2 TRIP15",yes,P61201 ENSG00000166233,ARIH1,E3 ligase ,RBR,Ariadne,,"ARIH1,ARI MOP6 UBCH7BP",yes,Q9Y4X5 ENSG00000166266,CUL5,E3 ligase ,CRL family,Cullin,,"CUL5,VACM1",yes,Q93034 ENSG00000166295,ANAPC16,E3 ligase ,APC,subunit,assorted ,"ANAPC16,C10orf104 CENP-27",yes,Q96DE5 ENSG00000166326,TRIM44,E3 ligase ,RING,TRIM,ringless & no CTD,"TRIM44,DIPB",yes,Q96DX7 ENSG00000166348,USP54,Ub and UBL demodifiers,USP,"assorted, large",,"USP54,C10orf29",yes,Q70EL1 ENSG00000166349,RAG1,E3 ligase ,RING,other,assorted,"RAG1,RNF74",no,P15918 ENSG00000166436,TRIM66,E3 ligase ,RING,TRIM,ringless & assorted CTD,"TRIM66,C11orf29 KIAA0298",yes,O15016 ENSG00000166439,RNF169,E3 ligase ,RING,other,assorted,"RNF169,KIAA1991",yes,Q8NCN4 ENSG00000166851,PLK1,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,SIM,"PLK1,PLK",yes,P53350 ENSG00000167118,URM1,ubiquitin and UBL proteins,ubiquitin-like modifier,URM1,,"URM1,C9orf74",yes,Q9BTM9 ENSG00000167196,FBXO22,E3 ligase ,CRL family,F-box,assorted,"FBXO22,FBX22",yes,Q8NEZ5 ENSG00000167257,RNF214,E3 ligase ,RING,other,assorted,"RNF214,",yes,Q8ND24 ENSG00000167333,TRIM68,E3 ligase ,RING,TRIM,SPRY - folded central helix,"TRIM68,GC109 RNF137 SS56",yes,Q6AZZ1 ENSG00000167470,MIDN,proteasome & associates,adaptors,UBL,UBL only,"MIDN,",yes,Q504T8 ENSG00000167487,KLHL26,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL26,",yes,Q53HC5 ENSG00000167671,UBXN6,p97 and associates,adaptors,"UBX, PUB, VIM",,"UBXN6,UBXD1 UBXDC2",yes,Q9BZV1 ENSG00000167770,OTUB1,p97 and associates,associated DUBs,OTU,UBXL,"OTUB1,OTB1, OTU1",yes,Q96FW1 ENSG00000167962,ZNF598,E3 ligase ,RING,other,assorted,"ZNF598,",yes,Q86UK7 ENSG00000167967,E4F1,E3 ligase ,assorted,,,"E4F1,E4F",yes,Q66K89 ENSG00000167977,KCTD5,E3 ligase ,CRL family,BTB,KCTD type,"KCTD5,",yes,Q9NXV2 ENSG00000167986,DDB1,E3 ligase ,CRL family,CRL adaptor,DDB1,"DDB1,XAP1",yes,Q16531 ENSG00000168090,COPS6,Ub and UBL demodifiers,CSN complex,deNEDDylase,"MPN, inactive","COPS6,CSN6 HVIP",yes,Q7L5N1 ENSG00000168159,RNF187,E3 ligase ,RING,TRIM,no CTD,"RNF187,",yes,Q5TA31 ENSG00000168246,UBTD2,ubiquitin and UBL proteins,UBL domain,non-enzymes,assorted ,"UBTD2,DCUBP",yes,Q8WUN7 ENSG00000168264,IRF2BP2,E3 ligase ,RING,IRF2 binding,,"IRF2BP2,",yes,Q7Z5L9 ENSG00000168283,BMI1,ubiquitin and UBL proteins,UBL domain,E3 ligases,RAWUL / polycomb,"BMI1,PCGF4 RNF51",yes,P35226 ENSG00000168300,PCMTD1,E3 ligase ,CRL family,SOCS box,assorted,"PCMTD1,",yes,Q96MG8 ENSG00000168301,KCTD6,E3 ligase ,CRL family,BTB,KCTD type,"KCTD6,",yes,Q8NC69 ENSG00000168411,RFWD3,E3 ligase ,RING,other,WD40,"RFWD3,RNF201",yes,Q6PCD5 ENSG00000168427,KLHL30,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL30,",yes,Q0D2K2 ENSG00000168591,TMUB2,ubiquitin and UBL proteins,UBL domain,non-enzymes,transmembrane,"TMUB2,",yes,Q71RG4 ENSG00000168883,USP39,Ub and UBL demodifiers,USP,UBP-ZnF,,"USP39,",yes,Q53GS9 ENSG00000168884,TNIP2,ubiquitin and UBL binding,NF-kappaB signalling,UBAN & NEMO-type ZnF,,"TNIP2,ABIN2 FLIP1",yes,Q8NFZ5 ENSG00000168894,RNF181,E3 ligase ,RING,other,assorted,"RNF181,",yes,Q9P0P0 ENSG00000168930,TRIM49,E3 ligase ,RING,TRIM,SPRY - folded central helix,"TRIM49,RNF18",no,P0CI25 ENSG00000168936,TMEM129,E3 ligase ,assorted,,,"TMEM129,",yes,A0AVI4 ENSG00000169018,FEM1B,E3 ligase ,CRL family,substrate adaptors,non-canonical,"FEM1B,F1AA KIAA0396",yes,Q9UK73 ENSG00000169139,UBE2V2,ubiquitin and UBL binding,"E2 conjugating enzyme, inactive","UEV, backside Ub binding",,"UBE2V2,MMS2 UEV2",yes,Q15819 ENSG00000169189,NSMCE1,E3 ligase ,RING,other,assorted,"NSMCE1,",yes,Q8WV22 ENSG00000169618,PROKR1,ubiquitin and UBL binding,assorted processes,SIM,,"PROKR1,GPR73 PKR1",no,Q8TCW9 ENSG00000169696,ASPSCR1,p97 and associates,adaptors,"UBX, UBXL, SHP",,"ASPSCR1,ASPL RCC17 TUG UBXD9 UBXN9",yes,Q9BZE9 ENSG00000169727,GPS1,Ub and UBL demodifiers,CSN complex,deNEDDylase,,"GPS1,COPS1 CSN1",yes,Q13098 ENSG00000169871,TRIM56,E3 ligase ,RING,TRIM,TolB-like,"TRIM56,RNF109",yes,Q9BRZ2 ENSG00000169905,TOR1AIP2,E3 ligase ,CRL family,DCAF,non-WD40,"TOR1AIP2,IFRG15",yes,Q8NFQ8 ENSG00000169914,OTUD3,Ub and UBL demodifiers,OTU,assorted,,"OTUD3,KIAA0459",yes,Q5T2D3 ENSG00000169918,OTUD7A,p97 and associates,associated DUBs,OTU ,"VBM, A20","OTUD7A,C15orf16 CEZANNE2 OTUD7",yes,Q8TE49 ENSG00000170035,UBE2E3,E2 conjugating enzymes,ubiquitylation,UBC domain & N-terminal extension,,"UBE2E3,UBCE4 UBCH9",yes,Q969T4 ENSG00000170142,UBE2E1,E2 conjugating enzymes,ubiquitylation,UBC domain & N-terminal extension,,"UBE2E1,UBCH6",yes,P51965 ENSG00000170145,SIK2,ubiquitin and UBL binding,protein kinases & regulators,salt-inducible Ser/Thr kinases,UBA,"SIK2,KIAA0781 QIK SNF1LK2",yes,Q9H0K1 ENSG00000170153,RNF150,E3 ligase ,RING,Goliath,,"RNF150,KIAA1214",yes,Q9ULK6 ENSG00000170185,USP38,Ub and UBL demodifiers,USP,"assorted, large",,"USP38,KIAA1891",yes,Q8NB14 ENSG00000170236,USP50,Ub and UBL demodifiers,USP,assorted,,"USP50,",yes,Q70EL3 ENSG00000170242,USP47,ubiquitin and UBL proteins,UBL domain,DUB,USP with external UBL,"USP47,",yes,Q96K76 ENSG00000170315,UBB,ubiquitin and UBL proteins,ubiquitin,polyubiquitin,,"UBB,",yes,P0CG47 ENSG00000170448,NFXL1,E3 ligase ,RING,NFX,,"NFXL1,OZFP",yes,Q6ZNB6 ENSG00000170500,LONRF2,E3 ligase ,RING,LON,TPR,"LONRF2,RNF192",yes,Q1L5Z9 ENSG00000170604,IRF2BP1,E3 ligase ,RING,IRF2 binding,,"IRF2BP1,",yes,Q8IU81 ENSG00000170633,RNF34,E3 ligase ,RING,SAP,,"RNF34,",yes,Q969K3 ENSG00000170677,SOCS6,E3 ligase ,CRL family,SOCS box,SH2 domain,"SOCS6,CIS4 SOCS4",yes,O14544 ENSG00000170734,POLH,ubiquitin and UBL binding,DNA repair,DNA polymerase,UBZ,"POLH,RAD30 RAD30A XPV",yes,Q9Y253 ENSG00000170832,USP32,ubiquitin and UBL proteins,UBL domain,DUB,USP with internal and external UBL,"USP32,USP10",yes,Q8NFA0 ENSG00000170852,KBTBD2,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KBTBD2,BKLHD1 KIAA1489",yes,Q8IY47 ENSG00000170881,RNF139,E3 ligase ,RING,other,assorted,"RNF139,TRC8",yes,Q8WU17 ENSG00000170967,DDI1,proteasome & associates,associated non-Ub enzymes,aspartic peptidase,,"DDI1,",yes,Q8WTU0 ENSG00000171150,SOCS5,E3 ligase ,CRL family,SOCS box,SH2 domain,"SOCS5,CIS6 CISH5 CISH6 KIAA0671",yes,O75159 ENSG00000171206,TRIM8,E3 ligase ,RING,TRIM,assorted CTD,"TRIM8,GERP RNF27",yes,Q9BZR9 ENSG00000171617,ENC1,E3 ligase ,CRL family,BTB,with BACK & KELCH,"ENC1,KLHL37 NRPB PIG10",yes,O14682 ENSG00000171621,SPSB1,E3 ligase ,CRL family,SOCS box,SPRY domain,"SPSB1,SSB1",yes,Q96BD6 ENSG00000171681,ATF7IP,ubiquitin and UBL binding,transcription,activation and repression,SIM,"ATF7IP,MCAF MCAF1",yes,Q6VMQ6 ENSG00000171823,FBXL14,E3 ligase ,CRL family,F-box,LRR,"FBXL14,FBL14",yes,Q8N1E6 ENSG00000171931,FBXW10,E3 ligase ,CRL family,F-box,WD40,"FBXW10,",yes,Q5XX13 ENSG00000172046,USP19,ubiquitin and UBL proteins,UBL domain,DUB,USP with internal UBL,"USP19,KIAA0891 ZMYND9",yes,O94966 ENSG00000172062,SMN1,ubiquitin and UBL binding,mRNA maturation,mRNA splicing,SIM,"SMN1,SMN SMNT",yes,Q16637 ENSG00000172354,GNB2,E3 ligase ,CRL family,DCAF,WD40,"GNB2,",yes,P62879 ENSG00000172476,RAB40A,E3 ligase ,CRL family,SOCS box,small GTPase,"RAB40A,",no,Q8WXH6 ENSG00000172578,KLHL6,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL6,",yes,Q8WZ60 ENSG00000172671,ZFAND4,ubiquitin and UBL proteins,UBL domain,non-enzymes,AN1,"ZFAND4,ANUBL1",yes,Q86XD8 ENSG00000172985,SH3RF3,E3 ligase ,RING,SH3,,"SH3RF3,POSH2 SH3MD4",yes,Q8TEJ3 ENSG00000173064,HECTD4,E3 ligase ,HECT,SPRY,,"HECTD4,C12orf51 KIAA0614",yes,Q9Y4D8 ENSG00000173120,KDM2A,E3 ligase ,CRL family,F-box,LRR with PHD-type ZnF,"KDM2A,CXXC8 FBL11 FBL7 FBXL11 JHDM1A KIAA1004",yes,Q9Y2K7 ENSG00000173163,COMMD1,E3 ligase ,CRL family,CRL regulator,CAND1 modulator,"COMMD1,C2orf5 MURR1",yes,Q8N668 ENSG00000173456,RNF26,E3 ligase ,RING,other,assorted,"RNF26,",yes,Q9BY78 ENSG00000173692,PSMD1,proteasome & associates,regulatory particle subunit,nonATPase,idiosyncratic Ub binding / Armadillo-like,"PSMD1,",yes,Q99460 ENSG00000173821,RNF213,E3 ligase ,RING,other,P-loop NTP hydrolase,"RNF213,ALO17 C17orf27 KIAA1554 KIAA1618 MYSTR",yes,Q63HN8 ENSG00000173838,10-Mar,E3 ligase ,RING,MARCH,,"MARCHF10,MARCH10 RNF190",yes,Q8NA82 ENSG00000173926,3-Mar,E3 ligase ,RING,MARCH,,"MARCHF3,MARCH3 RNF173",yes,Q86UD3 ENSG00000173960,UBXN2A,p97 and associates,adaptors,"UBX, SHP, SEP",,"UBXN2A,UBXD4",yes,P68543 ENSG00000174010,KLHL15,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL15,KIAA1677",yes,Q96M94 ENSG00000174013,FBXO45,E3 ligase ,CRL family,F-box,SPRY,"FBXO45,FBX45",yes,P0C2W1 ENSG00000174231,PRPF8,ubiquitin and UBL binding,mRNA maturation,mRNA splicing,idiosyncratic,"PRPF8,PRPC8",yes,Q6P2Q9 ENSG00000174292,TNK1,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,UBA,"TNK1,",yes,Q13470 ENSG00000174460,ZCCHC12,ubiquitin and UBL binding,transcription,coactivation,SIM,"ZCCHC12,SIZN1",yes,Q6PEW1 ENSG00000174516,PELI3,E3 ligase ,RING,Pellino,,"PELI3,",yes,Q8N2H9 ENSG00000174574,AKIRIN1,proteasome & associates,adaptors,Akirin,,"AKIRIN1,C1orf108",yes,Q9H9L7 ENSG00000174579,MSL2,E3 ligase ,RING,other,assorted,"MSL2,KIAA1585 MSL2L1 RNF184",yes,Q9HCI7 ENSG00000174672,BRSK2,ubiquitin and UBL binding,protein kinases & regulators,other Ser/Thr kinase,UBA,"BRSK2,C11orf7 PEN11B SADA STK29",yes,Q8IWQ3 ENSG00000174842,GLMN,E3 ligase ,CRL family,CRL regulator,inhibitor,"GLMN,FAP48 FAP68 VMGLOM",yes,Q92990 ENSG00000174943,KCTD13,E3 ligase ,CRL family,BTB,KCTD type,"KCTD13,BACURD1 PDIP1 POLDIP1",yes,Q8WZ19 ENSG00000174989,FBXW8,E3 ligase ,CRL family,F-box,WD40,"FBXW8,FBW6 FBW8 FBX29 FBXO29 FBXW6",yes,Q8N3Y1 ENSG00000175063,UBE2C,E2 conjugating enzymes,ubiquitylation,UBC domain & N-terminal extension,,"UBE2C,UBCH10",yes,O00762 ENSG00000175073,VCPIP1,p97 and associates,associated DUBs,OTU,UBXL,"VCPIP1,KIAA1850 VCIP135",yes,Q96JH7 ENSG00000175093,SPSB4,E3 ligase ,CRL family,SOCS box,SPRY domain,"SPSB4,SSB4",yes,Q96A44 ENSG00000175104,TRAF6,E3 ligase ,RING,"TRAF-type ZnF, MATH/TRAF ",,"TRAF6,RNF85",yes,Q9Y4K3 ENSG00000175166,PSMD2,proteasome & associates,regulatory particle subunit,nonATPase,Armadillo-like,"PSMD2,TRAP2",yes,Q13200 ENSG00000175518,UBQLNL,proteasome & associates,adaptors,UBL,UBL only,"UBQLNL,",yes,Q8IYU4 ENSG00000175520,UBQLN3,proteasome & associates,adaptors,UBL,with UBA,"UBQLN3,",yes,Q9H347 ENSG00000175556,LONRF3,E3 ligase ,RING,LON,TPR,"LONRF3,RNF127",yes,Q496Y0 ENSG00000175575,PAAF1,proteasome & associates,assembly chaperones,regulatory particle,,"PAAF1,WDR71",yes,Q9BRP4 ENSG00000175809,ZNF645,E3 ligase ,RING,Hakai,,"CBLL2,ZNF645",yes,Q8N7E2 ENSG00000175931,UBE2O,E2 conjugating enzymes,ubiquitylation,E2-E3 chimera,,"UBE2O,KIAA1734",yes,Q9C0C9 ENSG00000175946,KLHL38,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL38,C8orfK36",yes,Q2WGJ6 ENSG00000176125,UFSP1,Ub and UBL demodifiers,UFSP,inactive deURMylase,,"UFSP1,",no,Q6NVU6 ENSG00000176248,ANAPC2,E3 ligase ,APC,subunit,Cullin,"ANAPC2,APC2 KIAA1406",yes,Q9UJX6 ENSG00000176386,CDC26,E3 ligase ,APC,subunit,assorted ,"CDC26,ANAPC12 C9orf17",yes,Q8NHZ8 ENSG00000176399,DMRTA1,ubiquitin and UBL binding,transcription,DNA binding,UBA,"DMRTA1,DMO",yes,Q5VZB9 ENSG00000176407,KCMF1,E3 ligase ,RING,TRAC-1,,"KCMF1,FIGC ZZZ1",yes,Q9P0J7 ENSG00000176566,DCAF4L2,E3 ligase ,CRL family,DCAF,WD40,"DCAF4L2,WDR21C",yes,Q8NA75 ENSG00000176595,KBTBD11,E3 ligase ,CRL family,BTB,with KELCH ,"KBTBD11,CMLAP KIAA0711 KLHDC7C",yes,O94819 ENSG00000176624,MEX3C,E3 ligase ,RING,MEX3,,"MEX3C,RKHD2 RNF194",yes,Q5U5Q3 ENSG00000176641,RNF152,E3 ligase ,RING,other,assorted,"RNF152,",yes,Q8N8N0 ENSG00000176774,MAGEB18,E3 ligase ,RING cofactor,MAGE,,"MAGEB18,",no,Q96M61 ENSG00000176871,WSB2,E3 ligase ,CRL family,SOCS box,WD40,"WSB2,",yes,Q9NYS7 ENSG00000176953,NFATC2IP,ubiquitin and UBL proteins,UBL domain,nucleic acid processes,transcriptional modulator,"NFATC2IP,NIP45",yes,Q8NCF5 ENSG00000176979,TRIM60,E3 ligase ,RING,TRIM,SPRY,"TRIM60,RNF129 RNF33",no,Q495X7 ENSG00000177051,FBXO46,E3 ligase ,CRL family,F-box,only,"FBXO46,FBX46 FBXO34L",yes,Q6PJ61 ENSG00000177238,TRIM72,E3 ligase ,RING,TRIM,SPRY,"TRIM72,MG53",yes,Q6ZMU5 ENSG00000177294,FBXO39,E3 ligase ,CRL family,F-box,LRR,"FBXO39,FBX39",yes,Q8N4B4 ENSG00000177383,MAGEF1,E3 ligase ,RING cofactor,MAGE,,"MAGEF1,",yes,Q9HAY2 ENSG00000177414,UBE2U,E2 conjugating enzymes,ubiquitylation,UBC domain & C-terminal extension,,"UBE2U,",yes,Q5VVX9 ENSG00000177479,ARIH2,E3 ligase ,RBR,Ariadne,,"ARIH2,ARI2 TRIAD1",yes,O95376 ENSG00000177483,RBM44,ubiquitin and UBL binding,mRNA maturation,mRNA splicing,UBA,"RBM44,",yes,Q6ZP01 ENSG00000177688,SUMO4,ubiquitin and UBL proteins,ubiquitin-like modifier,SUMO,,"SUMO4,SMT3H4",no,Q6EEV6 ENSG00000177889,UBE2N,E2 conjugating enzymes,ubiquitylation,UBC domain only ,,"UBE2N,BLU",yes,P61088 ENSG00000177981,ASB8,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB8,",yes,Q9H765 ENSG00000178199,ZC3H12D,ubiquitin and UBL binding,mRNA decay (putative),UBA,,"ZC3H12D,C6orf95 MCPIP4 TFL",no,A2A288 ENSG00000178222,RNF212,E3 ligase ,RING,other,assorted,"RNF212,",yes,Q495C1 ENSG00000178381,ZFAND2A,proteasome & associates,adaptors,AN1,UBZ,"ZFAND2A,",yes,Q8N6M9 ENSG00000178498,DTX3,E3 ligase ,RING,Deltex,,"DTX3,RNF154",yes,Q8N9I9 ENSG00000178502,KLHL11,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL11,",yes,Q9NVR0 ENSG00000178685,PARP10,ubiquitin and UBL binding,other protein modifiers,ADP ribosyltransferase,UIM,"PARP10,",yes,Q53GL7 ENSG00000178809,TRIM73,E3 ligase ,RING,TRIM,no CTD,"TRIM73,TRIM50B",yes,Q86UV7 ENSG00000178828,RNF186,E3 ligase ,RING,other,assorted,"RNF186,",no,Q9NXI6 ENSG00000178974,FBXO34,E3 ligase ,CRL family,F-box,only,"FBXO34,FBX34",yes,Q9NWN3 ENSG00000179046,TRIML2,E3 ligase ,RING,TRIM,ringless & SPRY & folded central helix,"TRIML2,SPRYD6",yes,Q8N7C3 ENSG00000179222,MAGED1,E3 ligase ,RING cofactor,MAGE,,"MAGED1,NRAGE",yes,Q9Y5V3 ENSG00000179262,RAD23A,proteasome & associates,adaptors,UBL,with UBA,"RAD23A,",yes,P54725 ENSG00000179454,KLHL28,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL28,BTBD5",yes,Q9NXS3 ENSG00000179455,MKRN3,E3 ligase ,RING,Makorin,,"MKRN3,D15S9 RNF63 ZNF127",no,Q13064 ENSG00000179526,SHARPIN,ubiquitin and UBL proteins,UBL domain,E3 ligases,LUBAC complex,"SHARPIN,SIPL1",yes,Q9H0F6 ENSG00000179580,RNF151,E3 ligase ,RING,SIAH-type ZnF,TRAF-type ZnF,"RNF151,",yes,Q2KHN1 ENSG00000179859,AC025335.1,E3 ligase ,RING,other,assorted,"RNF227,LINC02581",yes,A6NIN4 ENSG00000180008,SOCS4,E3 ligase ,CRL family,SOCS box,SH2 domain,"SOCS4,SOCS7",yes,Q8WXH5 ENSG00000180233,ZNRF2,E3 ligase ,RING,ZNRF,,"ZNRF2,RNF202",yes,Q8NHG8 ENSG00000180537,RNF182,E3 ligase ,RING,other,assorted,"RNF182,",yes,Q8N6D2 ENSG00000180628,PCGF5,ubiquitin and UBL proteins,UBL domain,E3 ligases,RAWUL / polycomb,"PCGF5,RNF159",yes,Q86SE9 ENSG00000180667,YOD1,ubiquitin and UBL proteins,UBL domain,DUB,OTU,"YOD1,DUBA8 HIN7 OTUD2",yes,Q5VVQ6 ENSG00000180822,PSMG4,proteasome & associates,assembly chaperones,core particle,,"PSMG4,C6orf86 PAC4",yes,Q5JS54 ENSG00000180891,CUEDC1,ubiquitin and UBL binding,assorted processes,UBA,,"CUEDC1,",yes,Q9NWM3 ENSG00000180901,KCTD2,E3 ligase ,CRL family,BTB,KCTD type,"KCTD2,KIAA0176",yes,Q14681 ENSG00000181191,PJA1,E3 ligase ,RING,Praja,,"PJA1,RNF70",yes,Q8NG27 ENSG00000181481,RNF135,E3 ligase ,RING,SPRY but not TRIM,,"RNF135,",yes,Q8IUD6 ENSG00000181588,MEX3D,E3 ligase ,RING,MEX3,,"MEX3D,KIAA2031 RKHD1 RNF193",yes,Q86XN8 ENSG00000181788,SIAH2,E3 ligase ,RING,"SIAH-type ZnF, SIA TRAF-like domain",,"SIAH2,",yes,O43255 ENSG00000181852,RNF41,E3 ligase ,RING,SIAH-type ZnF,,"RNF41,FLRF NRDP1",yes,Q9H4P4 ENSG00000182053,TRIM49B,E3 ligase ,RING,TRIM,SPRY - folded central helix,"TRIM49B,RNF18B",no,A6NDI0 ENSG00000182177,ASB18,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB18,",no,Q6ZVZ8 ENSG00000182179,UBA7,E1 activating enzymes,ubiquitylation and ISG15ylation,,,"UBA7,UBE1L UBE2",yes,P41226 ENSG00000182247,UBE2E2,E2 conjugating enzymes,ubiquitylation and ISG15ylation,UBC domain & N-terminal extension,,"UBE2E2,UBCH8",yes,Q96LR5 ENSG00000182308,DCAF4L1,E3 ligase ,CRL family,DCAF,WD40,"DCAF4L1,WDR21B",yes,Q3SXM0 ENSG00000182325,FBXL6,E3 ligase ,CRL family,F-box,LRR,"FBXL6,FBL6",yes,Q8N531 ENSG00000182359,KBTBD3,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KBTBD3,BKLHD3",yes,Q8NAB2 ENSG00000182446,NPLOC4,p97 and associates,associated DUBs,MPN,UBXL,"NPLOC4,KIAA1499 NPL4",yes,Q8TAT6 ENSG00000182552,RWDD4,ubiquitin and UBL binding,assorted processes,RWD domain,,"RWDD4,FAM28A RWDD4A",yes,Q6NW29 ENSG00000182670,TTC3,E3 ligase ,RING,other,TPR,"TTC3,DCRR1 RNF105 TPRD",yes,P53804 ENSG00000182872,RBM10,ubiquitin and UBL binding,mRNA maturation,mRNA splicing,RanBP2-type ZnF,"RBM10,DXS8237E GPATC9 GPATCH9 KIAA0122",yes,P98175 ENSG00000182944,EWSR1,ubiquitin and UBL binding,transcription,repression,RanBP2-type ZnF,"EWSR1,EWS",yes,Q01844 ENSG00000182979,MTA1,ubiquitin and UBL binding,transcription,coactivation and corepression,SIM,"MTA1,",yes,Q13330 ENSG00000183439,TRIM61,E3 ligase ,RING,TRIM,no CTD & short central helix,"TRIM61,RNF35",yes,Q5EBN2 ENSG00000183475,ASB7,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB7,",yes,Q9H672 ENSG00000183496,MEX3B,E3 ligase ,RING,MEX3,,"MEX3B,KIAA2009 RKHD3 RNF195",yes,Q6ZN04 ENSG00000183527,PSMG1,proteasome & associates,assembly chaperones,core particle,,"PSMG1,C21LRP DSCR2 PAC1",yes,O95456 ENSG00000183579,ZNRF3,E3 ligase ,RING,other,assorted,"ZNRF3,KIAA1133 RNF203",yes,Q9ULT6 ENSG00000183580,FBXL7,E3 ligase ,CRL family,F-box,LRR,"FBXL7,FBL6 FBL7 KIAA0840",yes,Q9UJT9 ENSG00000183654,11-Mar,E3 ligase ,RING,MARCH,,"MARCHF11,MARCH11",yes,A6NNE9 ENSG00000183655,KLHL25,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL25,ENC2",yes,Q9H0H3 ENSG00000183718,TRIM52,E3 ligase ,RING,TRIM,no CTD & short central helix,"TRIM52,RNF102",yes,Q96A61 ENSG00000183735,TBK1,ubiquitin and UBL proteins,UBL domain,assorted enzymes ,kinase,"TBK1,NAK",yes,Q9UHD2 ENSG00000183763,TRAIP,E3 ligase ,RING,other,assorted,"TRAIP,RNF206 TRIP",yes,Q9BWF2 ENSG00000183826,BTBD9,E3 ligase ,CRL family,BTB,with BACK,"BTBD9,KIAA1880",yes,Q96Q07 ENSG00000184108,TRIML1,E3 ligase ,RING,TRIM,SPRY,"TRIML1,RNF209",yes,Q8N9V2 ENSG00000184182,UBE2F,E2 conjugating enzymes,NEDDylation,,,"UBE2F,NCE2",yes,Q969M7 ENSG00000184557,SOCS3,E3 ligase ,CRL family,SOCS box,SH2 domain,"SOCS3,CIS3 SSI3",yes,O14543 ENSG00000184787,UBE2G2,E2 conjugating enzymes,ubiquitylation,UBC domain only,,"UBE2G2,UBC7",yes,P60604 ENSG00000184887,BTBD6,E3 ligase ,CRL family,BTB,with BACK,"BTBD6,BDPL",yes,Q96KE9 ENSG00000184900,SUMO3,ubiquitin and UBL proteins,ubiquitin-like modifier,SUMO,,"SUMO3,SMT3A SMT3H1",yes,P55854 ENSG00000184979,USP18,Ub and UBL demodifiers,USP,assorted,,"USP18,ISG43",yes,Q9UMW8 ENSG00000184990,SIVA1,E3 ligase ,none,none,none,none,yes,none ENSG00000185019,UBOX5,E3 ligase ,RING,UBOX,,"UBOX5,KIAA0860 RNF37 UBCE7IP5 UIP5",yes,O94941 ENSG00000185104,FAF1,p97 and associates,adaptors,"UBX, thioredoxin-like, UBA",,"FAF1,UBXD12 UBXN3A",yes,Q9UNN5 ENSG00000185115,NSMCE3,E3 ligase ,RING cofactor,MAGE,,"NSMCE3,HCA4 MAGEG1 NDNL2",yes,Q96MG7 ENSG00000185247,MAGEA11,E3 ligase ,RING cofactor,MAGE,,"MAGEA11,MAGE11",yes,P43364 ENSG00000185262,UBALD2,ubiquitin and UBL binding,assorted processes,UBA,,"UBALD2,FAM100B",yes,Q8IYN6 ENSG00000185271,KLHL33,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL33,",yes,A6NCF5 ENSG00000185338,SOCS1,E3 ligase ,CRL family,SOCS box,SH2 domain,"SOCS1,SSI1 TIP3",yes,O15524 ENSG00000185345,PARK2,proteasome & associates,associated E3 ligase,"RING, UBL",,"PRKN,PARK2",yes,O60260 ENSG00000185515,BRCC3,Ub and UBL demodifiers,JAMM / MPN,assorted,,"BRCC3,BRCC36 C6.1A CXorf53",yes,P46736 ENSG00000185619,PCGF3,ubiquitin and UBL proteins,UBL domain,E3 ligases,RAWUL / polycomb,"PCGF3,RNF3 RNF3A",yes,Q3KNV8 ENSG00000185627,PSMD13,proteasome & associates,regulatory particle subunit,nonATPase,PCI,"PSMD13,",yes,Q9UNM6 ENSG00000185651,UBE2L3,E2 conjugating enzymes,ubiquitylation,UBC domain only ,,"UBE2L3,UBCE7 UBCH7",yes,P68036 ENSG00000185658,BRWD1,E3 ligase ,CRL family,DCAF,WD40 / with bromodomain,"BRWD1,C21orf107 WDR9",yes,Q9NSI6 ENSG00000185686,PRAME,E3 ligase ,CRL family,substrate adaptors,non-canonical / with TPR,"PRAME,MAPE OIP4",yes,P78395 ENSG00000185722,ANKFY1,E3 ligase ,CRL family,BTB,BTB only / with ankyrin repeats,"ANKFY1,ANKHZN KIAA1255",yes,Q9P2R3 ENSG00000185798,WDR53,E3 ligase ,CRL family,DCAF,WD40 / also APC,"WDR53,",yes,Q7Z5U6 ENSG00000185880,TRIM69,E3 ligase ,RING,TRIM,SPRY,"TRIM69,RNF36",yes,Q86WT6 ENSG00000185915,KLHL34,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL34,",yes,Q8N239 ENSG00000185972,CCIN,E3 ligase ,CRL family,BTB,with BACK & KELCH,"CCIN,",yes,Q13939 ENSG00000186150,UBL4B,ubiquitin and UBL proteins,UBL domain,chaperones and related,similar to UBL4A,"UBL4B,",yes,Q8N7F7 ENSG00000186187,ZNRF1,E3 ligase ,RING,ZNRF,,"ZNRF1,NIN283",yes,Q8ND25 ENSG00000186231,KLHL32,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL32,BKLHD5 KIAA1900",yes,Q96NJ5 ENSG00000186591,UBE2H,E2 conjugating enzymes,ubiquitylation,UBC domain & C-terminal extension,,"UBE2H,",yes,P62256 ENSG00000186660,ZFP91,E3 ligase ,assorted,,,"ZFP91,ZNF757",yes,Q96JP5 ENSG00000186871,ERCC6L,ubiquitin and UBL binding,DNA repair,DNA helicase,SIM,"ERCC6L,PICH",no,Q2NKX8 ENSG00000187147,RNF220,E3 ligase ,RING,other,assorted,"RNF220,C1orf164",yes,Q5VTB9 ENSG00000187555,USP7,ubiquitin and UBL proteins,UBL domain,DUB,USP with external UBL,"USP7,HAUSP",yes,Q93009 ENSG00000187566,NHLRC1,E3 ligase ,RING,other,NHL repeat,"NHLRC1,EPM2B",yes,Q6VVB1 ENSG00000187608,ISG15,ubiquitin and UBL proteins,ubiquitin-like modifier,ISG15,,"ISG15,G1P2 UCRP",yes,P05161 ENSG00000187715,KBTBD12,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KBTBD12,KLHDC6",yes,Q3ZCT8 ENSG00000187961,KLHL17,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL17,",yes,Q6TDP4 ENSG00000188021,UBQLN2,proteasome & associates,adaptors,UBL,with UBA,"UBQLN2,N4BP4 PLIC2",yes,Q9UHD9 ENSG00000188050,RNF133,E3 ligase ,RING,Goliath,,"RNF133,",yes,Q8WVZ7 ENSG00000188215,DCUN1D3,E3 ligase ,UBL modifiers,NEDDylation,PONY,"DCUN1D3,SCCRO3",yes,Q8IWE4 ENSG00000188612,SUMO2,ubiquitin and UBL proteins,ubiquitin-like modifier,SUMO,,"SUMO2,SMT3B SMT3H2",yes,P61956 ENSG00000188827,SLX4,ubiquitin and UBL binding,DNA repair,DNA endonuclease cofactor,UBZ & UIM & SIM,"SLX4,BTBD12 KIAA1784 KIAA1987",yes,Q8IY92 ENSG00000188997,KCTD21,E3 ligase ,CRL family,BTB,KCTD type,"KCTD21,",yes,Q4G0X4 ENSG00000189030,VHLL,E3 ligase ,CRL family,VHL,,"VHLL,VLP",no,Q6RSH7 ENSG00000189050,RNFT1,E3 ligase ,RING,other,assorted,"RNFT1,",yes,Q5M7Z0 ENSG00000189051,RNF222,E3 ligase ,RING,other,assorted,"RNF222,",yes,A6NCQ9 ENSG00000189091,SF3B3,E3 ligase ,CRL family,CRL adaptor,DDB1,"SF3B3,KIAA0017 SAP130",yes,Q15393 ENSG00000189186,DCAF8L2,E3 ligase ,CRL family,DCAF,WD40,"DCAF8L2,WDR42C",yes,P0C7V8 ENSG00000284413,BTBD8,E3 ligase ,CRL family,BTB,BTB only (KH only),"BTBD8,",no,Q5XKL5 ENSG00000189253,TRIM64B,E3 ligase ,RING,TRIM,SPRY,"TRIM64B,",no,A6NI03 ENSG00000189401,OTUD6A,Ub and UBL demodifiers,OTU,assorted,,"OTUD6A,DUBA2",yes,Q7L8S5 ENSG00000196141,SPATS2L,ubiquitin and UBL binding,assorted processes,UBA,,"SPATS2L,DNAPTP6",yes,Q9NUQ6 ENSG00000196151,WDSUB1,E3 ligase ,RING,UBOX,WD40,"WDSUB1,WDSAM1",yes,Q8N9V3 ENSG00000196363,WDR5,E3 ligase ,CRL family,DCAF,WD40,"WDR5,BIG3",yes,P61964 ENSG00000196372,ASB13,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB13,",yes,Q8WXK3 ENSG00000196470,SIAH1,E3 ligase ,RING,"SIAH-type ZnF, SIA TRAF-like domain",,"SIAH1,HUMSIAH",yes,Q8IUQ4 ENSG00000196510,ANAPC7,E3 ligase ,APC,subunit,TPR ,"ANAPC7,APC7",yes,Q9UJX3 ENSG00000196531,NACA,ubiquitin and UBL binding,translation ,nascent peptide binding,UBA,"NACA,",yes,Q13765 ENSG00000196531,NACA,ubiquitin and UBL binding,translation ,nascent peptide binding,UBA,"NACA,",yes,E9PAV3 ENSG00000196781,TLE1,E3 ligase ,CRL family,DCAF,WD40,"TLE1,",yes,Q04724 ENSG00000196821,C6orf106,ubiquitin and UBL binding,assorted processes,UBA,,"ILRUN,C6orf106",yes,Q9H6K1 ENSG00000196981,WDR5B,E3 ligase ,CRL family,DCAF,WD40,"WDR5B,",yes,Q86VZ2 ENSG00000197070,ARRDC1,E3 ligase ,HECT adaptor,,,"ARRDC1,",yes,Q8N5I2 ENSG00000197170,PSMD12,proteasome & associates,regulatory particle subunit,nonATPase,PCI,"PSMD12,",yes,O00232 ENSG00000197172,MAGEA6,E3 ligase ,RING cofactor,MAGE,,"MAGEA6,MAGE6",yes,P43360 ENSG00000197312,DDI2,proteasome & associates,associated non-Ub enzymes,aspartic peptidase,,"DDI2,",yes,Q5TDH0 ENSG00000197323,TRIM33,E3 ligase ,RING,TRIM,"PHD-type ZnF, Bromodomain","TRIM33,KIAA1113 RFG7 TIF1G",yes,Q9UPN9 ENSG00000197329,PELI1,E3 ligase ,RING,Pellino,,"PELI1,PRISM",yes,Q96FA3 ENSG00000197361,FBXL22,E3 ligase ,CRL family,F-box,only,"FBXL22,",yes,Q6P050 ENSG00000197429,IPP,E3 ligase ,CRL family,BTB,with BACK & KELCH,"IPP,KLHL27",yes,Q9Y573 ENSG00000197530,MIB2,E3 ligase ,RING,Mindbomb,,"MIB2,SKD ZZANK1",yes,Q96AX9 ENSG00000197562,RAB40C,E3 ligase ,CRL family,SOCS box,small GTPase,"RAB40C,RARL RASL8C",yes,Q96S21 ENSG00000197579,TOPORS,E3 ligase ,RING,other,assorted,"TOPORS,LUN TP53BPL",yes,Q9NS56 ENSG00000197705,KLHL14,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL14,KIAA1384",yes,Q9P2G3 ENSG00000197776,KLHDC1,E3 ligase ,CRL family,substrate adaptors,non-canonical / with KELCH,"KLHDC1,",yes,Q8N7A1 ENSG00000198060,5-Mar,E3 ligase ,RING,MARCH,,"MARCHF5,MARCH5 RNF153",yes,Q9NX47 ENSG00000198168,SVIP,p97 and associates,adaptors,VIM,,"SVIP,",yes,Q8NHG7 ENSG00000198171,DDRGK1,E3 ligase ,UBL modifiers,UFMylation adaptor,,"DDRGK1,C20orf116 UFBP1",yes,Q96HY6 ENSG00000198258,UBL5,ubiquitin and UBL proteins,ubiquitin-like modifier,UBL5,,"UBL5,",yes,Q9BZL1 ENSG00000198354,DCAF12L2,E3 ligase ,CRL family,DCAF,WD40,"DCAF12L2,WDR40C",yes,Q5VW00 ENSG00000198373,WWP2,E3 ligase ,HECT,WW & C2,NEDDylation,"WWP2,",yes,O00308 ENSG00000198612,COPS8,Ub and UBL demodifiers,CSN complex,deNEDDylase,,"COPS8,CSN8",yes,Q99627 ENSG00000198625,MDM4,E3 ligase ,RING,Mdm,,"MDM4,MDMX",yes,O15151 ENSG00000198642,KLHL9,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL9,KIAA1354",yes,Q9P2J3 ENSG00000198681,MAGEA1,E3 ligase ,RING cofactor,MAGE,,"MAGEA1,MAGE1 MAGE1A",yes,P43355 ENSG00000198690,FAN1,ubiquitin and UBL binding,DNA repair,DNA exonuclease,UBZ,"FAN1,KIAA1018 MTMR15",yes,Q9Y2M0 ENSG00000198742,SMURF1,E3 ligase ,HECT,WW & C2,ubiquitination,"SMURF1,KIAA1625",yes,Q9HCE7 ENSG00000198833,UBE2J1,E2 conjugating enzymes,ubiquitylation,UBC domain & transmembrane domain,,"UBE2J1,NCUBE1",yes,Q9Y385 ENSG00000198862,LTN1,E3 ligase ,RING,other,Armadillo-like,"LTN1,C21orf10 C21orf98 KIAA0714 RNF160 ZNF294",yes,O94822 ENSG00000198876,DCAF12,E3 ligase ,CRL family,DCAF,WD40,"DCAF12,KIAA1892 TCC52 WDR40A",yes,Q5T6F0 ENSG00000198881,ASB12,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB12,",yes,Q8WXK4 ENSG00000198889,DCAF12L1,E3 ligase ,CRL family,DCAF,WD40,"DCAF12L1,WDR40B",yes,Q5VU92 ENSG00000198919,DZIP3,E3 ligase ,RING,other,assorted,"DZIP3,KIAA0675",yes,Q86Y13 ENSG00000198924,DCLRE1A,ubiquitin and UBL binding,DNA repair,DNA exonuclease,UBZ,"DCLRE1A,KIAA0086 SNM1 SNM1A",yes,Q6PJP8 ENSG00000198933,TBKBP1,ubiquitin and UBL binding,NF-kappaB signalling,UBZ,,"TBKBP1,KIAA0775 SINTBAD",yes,A7MCY6 ENSG00000198961,PJA2,E3 ligase ,RING,Praja,,"PJA2,KIAA0438 RNF131",yes,O43164 ENSG00000203734,ECT2L,E3 ligase ,CRL family,F-box,assorted,"ECT2L,C6orf91 LFDH",no,Q008S8 ENSG00000203880,PCMTD2,E3 ligase ,CRL family,SOCS box,assorted,"PCMTD2,C20orf36",yes,Q9NV79 ENSG00000203995,ZYG11A,E3 ligase ,CRL family,substrate adaptors,"non-canonical / with TPR, Armadillo-like","ZYG11A,ZYG11",yes,Q6WRX3 ENSG00000204209,DAXX,ubiquitin and UBL binding,protein quality control,protein folding & quality control,SIM,"DAXX,BING2 DAP6",yes,Q9UER7 ENSG00000204227,RING1,ubiquitin and UBL proteins,UBL domain,E3 ligases,RAWUL / polycomb ,"RING1,RNF1",yes,Q06587 ENSG00000204264,PSMB8,proteasome & associates,core particle subunit,specialized,beta subunit,"PSMB8,LMP7 PSMB5i RING10 Y2",yes,P28062 ENSG00000204308,RNF5,E3 ligase ,RING,other,assorted,"RNF5,G16 NG2 RMA1",yes,Q99942 ENSG00000204449,TRIM49C,E3 ligase ,RING,TRIM,SPRY - folded central helix,"TRIM49C,TRIM49L2",no,P0CI26 ENSG00000204450,TRIM64,E3 ligase ,RING,TRIM,SPRY,"TRIM64,C11orf28",no,A6NGJ6 ENSG00000204463,BAG6,proteasome & associates,associated non-Ub enzymes,chaperone,,"BAG6,BAT3 G3",yes,P46379 ENSG00000204501,PRAMEF15,E3 ligase ,CRL family,substrate adaptors,non-canonical / with TPR,"PRAMEF9,",no,P0DUQ2 ENSG00000204599,TRIM39,E3 ligase ,RING,TRIM,SPRY,"TRIM39,RNF23 TFP",yes,Q9HCM9 ENSG00000204610,TRIM15,E3 ligase ,RING,TRIM,SPRY,"TRIM15,RNF93 ZNF178 ZNFB7",no,Q9C019 ENSG00000204613,TRIM10,E3 ligase ,RING,TRIM,SPRY,"TRIM10,RFB30 RNF9",no,Q9UDY6 ENSG00000204614,TRIM40,E3 ligase ,RING,TRIM,no CTD & folded helix,"TRIM40,RNF35",no,Q6P9F5 ENSG00000204616,TRIM31,E3 ligase ,RING,TRIM,assorted CTD,"TRIM31,C6orf13 RNF",yes,Q9BZY9 ENSG00000204618,RNF39,E3 ligase ,RING,SPRY but not TRIM,,"RNF39,HZFW",yes,Q9H2S5 ENSG00000204619,PPP1R11,E3 ligase ,assorted,,,"PPP1R11,HCGV TCTE5",yes,O60927 ENSG00000204713,TRIM27,E3 ligase ,RING,TRIM,SPRY,"TRIM27,RFP RNF76",yes,P14373 ENSG00000204923,FBXO48,E3 ligase ,CRL family,F-box,only,"FBXO48,FBX48",no,Q5FWF7 ENSG00000204952,FBXO47,E3 ligase ,CRL family,F-box,only,"FBXO47,",no,Q5MNV8 ENSG00000204977,TRIM13,E3 ligase ,RING,TRIM,TM,"TRIM13,LEU5 RFP2 RNF77",yes,O60858 ENSG00000205220,PSMB10,proteasome & associates,core particle subunit,specialized,beta subunit,"PSMB10,LMP10 MECL1",yes,P40306 ENSG00000205678,TECRL,ubiquitin and UBL proteins,UBL domain,assorted enzymes ,enoyl-CoA reductase,"TECRL,SRD5A2L2",yes,Q5HYJ1 ENSG00000205784,ARRDC5,E3 ligase ,HECT adaptor,,,"ARRDC5,",yes,A6NEK1 ENSG00000206199,ANKUB1,ubiquitin and UBL proteins,UBL domain,non-enzymes,ankyrin repeat,"ANKUB1,C3orf16",no,A6NFN9 ENSG00000206557,TRIM71,E3 ligase ,RING,TRIM,"FIL, TolB-like","TRIM71,LIN41",yes,Q2Q1W2 ENSG00000212864,RNF208,E3 ligase ,RING,other,assorted,"RNF208,",yes,Q9H0X6 ENSG00000213160,KLHL23,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL23,",yes,Q8NBE8 ENSG00000213186,TRIM59,E3 ligase ,RING,TRIM,TM,"TRIM59,RNF104 TRIM57 TSBF1",yes,Q8IWR1 ENSG00000213341,CHUK,ubiquitin and UBL proteins,UBL domain,assorted enzymes ,kinase,"CHUK,IKKA TCF16",yes,O15111 ENSG00000213401,MAGEA12,E3 ligase ,RING cofactor,MAGE,,"MAGEA12,MAGE12",no,P43365 ENSG00000213859,KCTD11,E3 ligase ,CRL family,BTB,KCTD type,"KCTD11,C17orf36 REN",yes,Q693B1 ENSG00000214050,FBXO16,E3 ligase ,CRL family,F-box,only,"FBXO16,FBX16",yes,Q8IX29 ENSG00000214357,NEURL1B,E3 ligase ,RING,Neuralized,SPRY / NHR,"NEURL1B,NEURL3",yes,A8MQ27 ENSG00000214414,TRIM77,E3 ligase ,RING,TRIM,SPRY,"TRIM77,TRIM77P",no,I1YAP6 ENSG00000214655,ZSWIM8,E3 ligase ,CRL family,substrate adaptors,non-canonical / SWIM-type ZnF,"ZSWIM8,KIAA0913",yes,A7E2V4 ENSG00000214717,ZBED1,E3 ligase ,UBL modifiers,sumoylation,non-MIZ,"ZBED1,ALTE DREF hDREF KIAA0785 TRAMP",yes,O96006 ENSG00000214891,TRIM64C,E3 ligase ,RING,TRIM,SPRY,"TRIM64C,",no,A6NLI5 ENSG00000215041,NEURL4,E3 ligase ,assorted,NHR,,"NEURL4,KIAA1787",yes,Q96JN8 ENSG00000215114,UBXN2B,p97 and associates,adaptors,"UBX, SHP, SEP",,"UBXN2B,[p37]",yes,Q14CS0 ENSG00000215218,UBE2QL1,E2 conjugating enzymes,ubiquitylation,UBC domain only,,"UBE2QL1,",yes,A1L167 ENSG00000215277,RNF212B,E3 ligase ,RING,other,assorted,"RNF212B,C14orf164",yes,A8MTL3 ENSG00000215475,SIAH3,E3 ligase ,RING,SIA TRAF-like domain,,"SIAH3,",yes,Q8IW03 ENSG00000221867,MAGEA3,E3 ligase ,RING cofactor,MAGE,,"MAGEA3,MAGE3",yes,P43357 ENSG00000221926,TRIM16,E3 ligase ,RING,TRIM,ringless & SPRY,"TRIM16,EBBP",yes,O95361 ENSG00000221983,UBA52,ubiquitin and UBL proteins,ubiquitin,ribosomal ubiquitin fusion,,"UBA52,UBCEP2",yes,P62987 ENSG00000222009,BTBD19,E3 ligase ,CRL family,BTB,with BACK,"BTBD19,",yes,C9JJ37 ENSG00000222028,PSMB11,proteasome & associates,core particle subunit,specialized,beta subunit,"PSMB11,",no,A5LHX3 ENSG00000223443,USP17L2,Ub and UBL demodifiers,USP,assorted,,"USP17L2,DUB3 USP17 USP17H USP17I USP17J USP17K USP17L USP17M",no,Q6R6M4 ENSG00000223573,TINCR,ubiquitin and UBL proteins,UBL domain,non-enzymes,assorted ,"TINCR,LINC00036 NCRNA00036 PLAC2",yes,A0A2R8Y7D0 ENSG00000223638,RFPL4A,E3 ligase ,RING,SPRY but not TRIM,,"RFPL4A,RFPL4 RNF210",no,A6NLU0 ENSG00000226372,DCAF8L1,E3 ligase ,CRL family,DCAF,WD40,"DCAF8L1,WDR42B",no,A6NGE4 ENSG00000229292,RFPL4AL1,E3 ligase ,RING,SPRY but not TRIM,,"RFPL4AL1,",no,F8VTS6 ENSG00000229547,UBE2DNL,ubiquitin and UBL binding,assorted processes,UEV,,"UBE2DNL,UBE2D2L",yes,Q8IWF7 ENSG00000232423,PRAMEF6,E3 ligase ,CRL family,substrate adaptors,non-canonical / with TPR,"PRAMEF6,",no,Q5VXH4 ENSG00000233198,RNF224,E3 ligase ,RING,other,assorted,"RNF224,",yes,P0DH78 ENSG00000233802,TRIM49D2,E3 ligase ,RING,TRIM,SPRY - folded central helix,"TRIM49D1,TRIM49L TRIM49L1",no,C9J1S8 ENSG00000234127,TRIM26,E3 ligase ,RING,TRIM,SPRY,"TRIM26,RNF95 ZNF173",yes,Q12899 ENSG00000234438,KBTBD13,E3 ligase ,CRL family,BTB,with KELCH ,"KBTBD13,",yes,C9JR72 ENSG00000235631,RNF148,E3 ligase ,RING,Goliath,,"RNF148,",yes,Q8N7C7 ENSG00000236444,UBE2L5P,E2 conjugating enzymes,ubiquitylation,UBC domain only ,,"UBE2L5,",yes,A0A1B0GUS4 ENSG00000237330,RNF223,E3 ligase ,RING,other,assorted,"RNF223,",yes,E7ERA6 ENSG00000239305,RNF103,E3 ligase ,RING,other,assorted,"RNF103,ZFP103",yes,O00237 ENSG00000239388,ASB14,E3 ligase ,CRL family,SOCS box,ankyrin repeats,"ASB14,",yes,A6NK59 ENSG00000239474,KLHL41,E3 ligase ,CRL family,BTB,with BACK & KELCH,"KLHL41,KBTBD10 KRP1",yes,O60662 ENSG00000240065,PSMB9,proteasome & associates,core particle subunit,specialized,beta subunit,"PSMB9,LMP2 PSMB6i RING12",yes,P28065 ENSG00000241322,CDRT1,E3 ligase ,CRL family,F-box,WD40,"CDRT1,C17orf1 C17orf1A HREP",yes,O95170 ENSG00000241721,SUMO1P1,ubiquitin and UBL proteins,ubiquitin-like modifier,SUMO,,"SUMO1P1,SUMO5 UBL2 UBL6",yes,G2XKQ0 ENSG00000242028,HYPK,ubiquitin and UBL binding,other protein modifiers,N-terminal acetylation,UBA,"HYPK,C15orf63",yes,Q9NX55 ENSG00000244234,GMCL1P1,E3 ligase ,CRL family,BTB,BTB only (KH & Bioplex),"GMCL2,GCL GMCL1L GMCL1P1",yes,Q8NEA9 ENSG00000244687,UBE2V1,ubiquitin and UBL binding,"E2 conjugating enzyme, inactive","UEV, backside Ub binding",,"UBE2V1,CROC1 UBE2V UEV1",yes,Q13404 ENSG00000246922,UBAP1L,ubiquitin and UBL binding,assorted processes,UBA,,"UBAP1L,",yes,F5GYI3 ENSG00000247746,USP51,Ub and UBL demodifiers,USP,UBP-ZnF,,"USP51,",yes,Q70EK9 ENSG00000250374,TRIM75P,E3 ligase ,RING,TRIM,SPRY,"TRIM75P,TRIM75",no,A6NK02 ENSG00000251258,RFPL4B,E3 ligase ,RING,SPRY but not TRIM,,"RFPL4B,RNF211",no,Q6ZWI9 ENSG00000253506,NACA2,ubiquitin and UBL binding,translation ,nascent peptide binding,UBA,"NACA2,NACAL",yes,Q9H009 ENSG00000254585,MAGEL2,E3 ligase ,RING cofactor,MAGE,,"MAGEL2,NDNL1",yes,Q9UJ55 ENSG00000254726,MEX3A,E3 ligase ,RING,MEX3,,"MEX3A,RKHD4",yes,A1L020 ENSG00000258659,TRIM34,E3 ligase ,RING,TRIM,SPRY,"TRIM34,IFP1 RNF21",yes,Q9BYJ4 ENSG00000261609,GAN,E3 ligase ,CRL family,BTB,with BACK & KELCH,"GAN,GAN1 KLHL16",yes,Q9H2C0 ENSG00000263528,IKBKE,ubiquitin and UBL proteins,UBL domain,assorted enzymes ,kinase,"IKBKE,IKKE IKKI KIAA0151",yes,Q14164 ENSG00000264522,OTUD7B,p97 and associates,associated DUBs,OTU ,"VBM, A20","OTUD7B,ZA20D1",yes,Q6GQQ9 ENSG00000265491,RNF115,E3 ligase ,RING,other,assorted,"RNF115,ZNF364",yes,Q9Y4L5 ENSG00000265972,TXNIP,E3 ligase ,HECT adaptor,,,"TXNIP,VDUP1",yes,Q9H3M7 ENSG00000268606,MAGEA2,E3 ligase ,RING cofactor,MAGE,,"MAGEA2,MAGE2 MAGEA2A",no,P43356 ENSG00000268629,TEX13A,ubiquitin and UBL binding,transcription,repression,RanBP2-type ZnF,"TEX13A,",yes,Q9BXU3 ENSG00000269190,FBXO17,E3 ligase ,CRL family,F-box,FBA,"FBXO17,FBG4 FBX17 FBX26 FBXO26",yes,Q96EF6 ENSG00000269335,IKBKG,ubiquitin and UBL binding,NF-kappaB signalling,UBAN & NEMO-type ZnF,,"IKBKG,FIP3 NEMO",yes,Q9Y6K9 ENSG00000269437,NXF2B,ubiquitin and UBL binding,mRNA export,UBA,,"NXF2,TAPL2",no,Q9GZY0 ENSG00000269855,RNF225,E3 ligase ,RING,other,assorted,"RNF225,",yes,M0QZC1 ENSG00000270647,TAF15,ubiquitin and UBL binding,transcription,initiation,RanBP2-type ZnF,"TAF15,RBP56 TAF2N",yes,Q92804 ENSG00000273820,USP27X,Ub and UBL demodifiers,USP,assorted,,"USP27X,USP22L USP27",yes,A6NNY8 ENSG00000274211,SOCS7,E3 ligase ,CRL family,SOCS box,SH2 domain,"SOCS7,NAP4 SOCS6",yes,O14512 ENSG00000276043,UHRF1,ubiquitin and UBL proteins,UBL domain,E3 ligases,DNA repair,"UHRF1,ICBP90 NP95 RNF106",yes,Q96T88 ENSG00000277258,PCGF2,ubiquitin and UBL proteins,UBL domain,E3 ligases,RAWUL / polycomb,"PCGF2,MEL18 RNF110 ZNF144",yes,P35227 ENSG00000277791,PSMB3,proteasome & associates,core particle subunit,constitutive,beta subunit,"PSMB3,",yes,P49720 ENSG00000282419,TEX13D,ubiquitin and UBL binding,transcription,repression,RanBP2-type ZnF,"TEX13D,",yes,A0A0J9YY54 ENSG00000282815,TEX13C,ubiquitin and UBL binding,transcription,repression,RanBP2-type ZnF,"TEX13C,",no,A0A0J9YWL9 ENSG00000116957,TBCE,ubiquitin and UBL proteins,UBL domain,chaperones and related,tubulin-associated,"TBCE,",no,Q15813 ENSG00000164616,FBL21,E3 ligase ,CRL family,F-box,LRR,"FBXL21P,FBL21 FBL3 FBXL21 FBXL3B FBXL3P",no,Q9UKT6 ENSG00000224831,RP11-651P23.4,E3 ligase ,CRL family,F-box,transmembrane,"TMEM183B,C1orf37-dup",no,Q1AE95 ENSG00000161133,USP41,Ub and UBL demodifiers,USP,assorted,,"USP41,",no,Q3LFD5 ubiquitin and UBL binding,protein kinases & regulators,salt-inducible Ser/Thr kinases,UBA,"SIK1B,",no,A0A0B4J2F2,, ENSG00000276380,UBE2NL,ubiquitin and UBL binding,assorted processes,UEV,,"UBE2NL,",no,Q5JXB2