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#  Associations of maternal night shiftwork during pregnancy with DNA methylation in offspring: 
#  A meta-analysis in the PACE Consortium
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#  README file
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#  File description
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- MA_M1_crude_model_MatShiftWork.csv: genome-wide meta-analysis results for model adjusted for child sex and batch
- MA_M2_reduced_model_MatShiftWork.csv: genome-wide meta-analysis results for model adjusted for child sex, batch, and maternal covariates
- MA_M3_main_model_MatShiftWork.csv: genome-wide meta-analysis results for model adjusted for child sex, batch, maternal covariates, and cell type proportions

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# File Headers description
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### METAL columns
- MarkerName - CpG name
- Allele1 - NA
- Allele2 - NA
- Effect - overall estimated effect size
- StdErr - overall standard error for effect size estimate
- P.value - meta-analysis p-value
- Direction - summary of effect direction for each study, with one '+' or '-' per study, alphabetically
- HetISq - I^2 statistic which measures heterogeneity on scale of 0-100%
- HetChiSq - chi-squared statistic in simple test of heterogeneity
- HetDf - degrees of freedom for heterogeneity statistic
- HetPVal - P-value for heterogeneity statistic

### Illumina annotation columns
- IlmnID = MarkerName
- Genome_Build - reference genome
- CHR -  Chromosome containing the CpG
- MAPINFO - Chromosomal coordinates of the CpG
- Strand - The Forward (F) or Reverse (R) designation of the Design Strand
- Probe_SNPs - rsid(s) of SNP(s) located 10­-50 bases from the target CpG
- Probe_SNPs_10 - rsid(s) of SNP(s) located ≤ 10 bases from the target CpG
- UCSC_RefGene_Name - Target gene names, from the UCSC database. Multiple listings of the same gene name indicate splice variants
- UCSC_RefGene_Accession - The UCSC accession numbers of the target transcripts. Accession numbers are in the same order as the target gene transcripts
- UCSC_RefGene_Group - Gene region feature category describing the CpG position, from UCSC. Features are listed in the same order as the target gene transcripts. 
	- TSS200 = 0-200 bases upstream of the transcriptional start site (TSS)
	- TSS1500 = 200-1500 bases upstream of the TSS.
	- 5'UTR = Within the 5' untranslated region, between the TSS and the ATG start site.
	- Body = Between the ATG and stop codon; irrespective of the presence of introns, exons, TSS, or promoters.
	- 3'UTR = Between the stop codon and poly A signal.
- UCSC_CpG_Islands_Name - Chromosomal coordinates of the CpG Island from UCSC
- Relation_to_UCSC_CpG_Island - The location of the CpG relative to the CpG island
	- Shore = 0-2 kb from island
	- Shelf = 2-4 kb from island
	- N = Upstream (5’) of CpG island
	- S = Downstream (3’) of CpG island
- Phantom - Classifications from the FANTOM (Functional Annotation of the Mammalian Genome) consortium as a low- or high-CpG density region associated with FANTOM 4 promoters
- DMR - Differentially methylated regions (experimentally determined)
	- DMR = Differentially Methylated Region
	- CDMR = Cancer-specific Differentially Methylated Region
	- RDMR = Reprogramming-specific Differentially Methylated Region
- Enhancer - Predicted enhancer elements as annotated in the original 450K design (informatically determined by the ENCODE Consortium) are marked True.
- HMM_Island - Hidden Markov Model Islands. Chromosomal map coordinates of computationally predicted CpG islands
- Regulatory_Feature_Name -  Chromosomal map coordinates of the regulatory feature (informatically determined by the ENCODE Consortium)
- Regulatory_Feature_Group - Description of the regulatory feature referenced in Regulatory_Feature_Name, as provided by the Methylation Consortium
- DHS - DNase I Hypersensitivity Site (experimentally determined by the ENCODE project)
- flag - Probes listed as potentially polymorphic
- P.value.FDR - P value corrected at 5% false discovery rate