Reduces the methytmle
object by way of a limma
model with
empirical Bayes shrinkage to include only the CpG sites below the preset
p-value cutoff. INTERNAL USE ONLY.
limma_screen(methytmle, var_int, type, cutoff = 0.05)
methytmle | An object of class |
---|---|
var_int | A |
type | Character indicating the particular measure of DNA methylation to
be used as the observed data in the estimation procedure, either Beta
values or M-values. The data are accessed via |
cutoff | Numeric indicating the p-value cutoff that defines which
sites pass through the |
An object of class methytmle
, that is a subset of the original
methytmle input object which has been reduced include only the relevant CpG
sites. This subset is then used to estimate VIMs.