The evolution of mobile networks is converging with the pervasive digitalization of the industrial/ manufacturing sector, which is demanding highly reliable and deterministic wireless networking. The performance levels of wireless networks are greatly enhanced from one generation to the next, but the variability of performance, especially with regards to latency, remains an issue to be addressed since most protocols and solutions are designed with the assumption that underlying networks shall deliver performance levels with very low variability, as it is the case, for example, of Ethernet networks. In this work, we address this critical issue, proposing and validating a novel solution approach for achieving effective de-jittering in 3GPP networks that does not require the modification of the end-user traffic (e.g. timestamping), thus enabling its implementation on current 5G networks without demanding special UEs or new 5GS capabilities. This solution approach is validated over a real 5G network deployed at 5Tonic laboratory.