Published July 8, 2024
| Version v1
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Open
Gene-collapsing analysis of clonal haematopoiesis in 136,401 Admixed Americans and 416,118 Europeans
Authors/Creators
- Wen, Sean (Researcher)1, 2
- Kuri-Morales, Pablo
- Hu, Fengyuan
- Nag, Abhishek
- Tachmazidou, Ioanna
- Deevi, Sri V. V.
- Taiy, Haeyam
- Smith, Katherine
- Loesch, Douglas P.
- Burren, Oliver S.
- Dhindsa, Ryan S.
- Wasilewski, Sebastian
- Alegre-Díaz, Jesus
- Berumen, Jaime
- Emberson, Jonathan
- Torres, Jason M.
- Collins, Rory
- Carss, Keren
- Wang, Quanli
- Petrovski, Slavé
- Tapia-Conyer, Roberto
- Fabre, Margarete A.
- Harper, Andrew R.
- Vassiliou, George
- Mitchell, Jonathan
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1.
AstraZeneca (United Kingdom)
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2.
University of Cambridge
Description
We performed gene-collapsing (gene burden) analysis of germline genetic variants identified from whole-exome sequencing (WES) to identify novel inherited genetic determinants of clonal haematopoiesis (CH). Here, we provide the summary statistics from CH gene-collapsing analysis performed on Admixed Americans recruited to the Mexico City Prospective Study (MCPS), Europeans recruited to the United Kingdom Biobank (UKB), and cross-ancestry meta-analysis of Admixed Americans and Europeans. Analyses was performed with Fisher's exact test (for MCPS and UKB analysis) and Cochran–Mantel–Haenszel test (for meta-analysis).
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