Published July 8, 2024
| Version v1
Dataset
Open
Exome-wide association analysis (ExWAS) of clonal haematopoiesis in 136,401 Admixed Americans and 416,118 Europeans
Authors/Creators
- Wen, Sean (Researcher)1, 2
- Kuri-Morales, Pablo
- Hu, Fengyuan
- Nag, Abhishek
- Tachmazidou, Ioanna
- Deevi, Sri V. V.
- Taiy, Haeyam
- Smith, Katherine
- Loesch, Douglas P.
- Burren, Oliver S.
- Dhindsa, Ryan S.
- Wasilewski, Sebastian
- Alegre-Díaz, Jesus
- Berumen, Jaime
- Emberson, Jonathan
- Torres, Jason M.
- Collins, Rory
- Carss, Keren
- Wang, Quanli
- Petrovski, Slavé
- Tapia-Conyer, Roberto
- Fabre, Margarete A.
- Harper, Andrew R.
- Vassiliou, George
- Mitchell, Jonathan
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1.
AstraZeneca (United Kingdom)
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2.
University of Cambridge
Description
We performed exome-wide association analysis (ExWAS) of germline genetic variants identified from whole-exome sequencing (WES) to identify novel inherited genetic determinants of clonal haematopoiesis (CH). Here, we provide the summary statistics from ExWAS CH performed on Admixed Americans recruited to the Mexico City Prospective Study (MCPS), Europeans recruited to the United Kingdom Biobank (UKB), and cross-ancestry meta-analysis of Admixed Americans and Europeans. Analyses was performed with REGENIE software (Firth's logistic regression), Fisher's exact test, and METAL software (inverse variance-weighted average method to derive effect size and P-value method to derive P value), respectively.
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