"AU","AF","TI","PY","SO","VL","PP","TC","DI","C1","AB","DE","ID","FU","FX","CR","RP","PU","LA","JI","DT","DB","UT","J9","AU_UN","AU1_UN","AU_UN_NR","SR_FULL","SR"
"CRAVOTTO G;CALCIO G E;BARGE A;BINELLO A;ALBERTINO A;AGHEMO C","CRAVOTTO, GIANCARLO (7003394420); CALCIO GAUDINO, EMANUELA (23488197200); BARGE, ALESSANDRO (7003400236); BINELLO, ARIANNA (6603442129); ALBERTINO, ANDREA (15838843300); AGHEMO, COSTANZA (36165375600)","SYNTHESIS OF 1OCTACOSANOL AND GCCIRMS DISCRIMINATION OF SAMPLES FROM DIFFERENT ORIGIN",2010,"NATURAL PRODUCT RESEARCH","24","11",14,"10.1080/14786410903194498","DIPARTIMENTO DI SCIENZA E TECNOLOGIA DEL FARMACO, UNIVERSITÀ DI TORINO, 10125 TORINO, ITALY;DIPARTIMENTO DI SCIENZA E TECNOLOGIA DEL FARMACO, UNIVERSITÀ DI TORINO, 10125 TORINO, ITALY;DIPARTIMENTO DI SCIENZA E TECNOLOGIA DEL FARMACO, UNIVERSITÀ DI TORINO, 10125 TORINO, ITALY;DIPARTIMENTO DI SCIENZA E TECNOLOGIA DEL FARMACO, UNIVERSITÀ DI TORINO, 10125 TORINO, ITALY;DIPARTIMENTO DI CHIMICA, IFM, UNIVERSITÀ DI TORINO, 10125 TORINO, ITALY;DIPARTIMENTO DI CHIMICA, IFM, UNIVERSITÀ DI TORINO, 10125 TORINO, ITALY","LATELY, LONG-CHAIN PRIMARY ALCOHOLS HAVE BEEN INVESTIGATED IN DEPTH ON ACCOUNT OF THEIR BIOLOGICAL ACTIVITIES. IN PARTICULAR, 1-OCTACOSANOL (C 28H57OH), THE MAIN COMPONENT OF POLICOSANOL, THE HYPOLIPIDAEMIC FATTY ALCOHOL MIXTURE OBTAINED FROM SUGAR CANE WAX, HAS BEEN THE SUBJECT OF A MULTITUDE OF PHARMACOLOGICAL STUDIES. THE AIM OF THIS WORK WAS TO SEARCH A CONVENIENT SYNTHETIC PROTOCOL FOR THE PREPARATION OF 1-OCTACOSANOL IN A GRAM SCALE. THE KEY STEP WAS A WITTIG REACTION BETWEEN THE OCTADECYLTRIPHENYLPHOSPHONIUM YLIDE AND THE METHYL 10-OXODECANOATE. SOME STEPS WERE FURTHER IMPROVED BY POWER ULTRASOUND AND MICROWAVE IRRADIATION, EITHER ALONE OR IN COMBINATION. OUR METHODOLOGY IS SUITABLE FOR A RAPID GENERATION OF HOMOLOGUES BY VARYING THE CHAIN LENGTH IN THE ALKYL HALIDE. DUE TO THE HIGH COMMERCIAL VALUE, A SERIES OF 1-OCTACOSANOL SAMPLES, EITHER ISOLATED FROM NATURAL SOURCES OR FROM SYNTHESIS (DIFFERENT ORIGIN AND SUPPLIERS), WERE ANALYSED BY GAS CHROMATOGRAPHY-COMBUSTION-ISOTOPIC RATIO MASS SPECTROMETRY (GC-C-IRMS) AND ACCORDING TO THE CARBON ISOTOPIC CONTENT, CLASSIFIED ON THE BASIS OF THEIR ORIGIN. © 2010 TAYLOR & FRANCIS.","GC-C-IRMS; MICROWAVES; OCTACOSANOL; SYNTHESIS; ULTRASOUND","FATTY ALCOHOLS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MAGNETIC RESONANCE SPECTROSCOPY; MICROWAVES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SACCHARUM; 1 OCTACOSANOL; DECANOIC ACID DERIVATIVE; METHYL 10 OXODECANOATE; OCTACOSANOL; OCTADECYLTRIPHENYLPHOSPHONIUM YLIDE; UNCLASSIFIED DRUG; ARTICLE; COMBUSTION; DRUG SYNTHESIS; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; MICROWAVE IRRADIATION; WITTIG REACTION","UNIVERSITÀ DEGLI STUDI DI TORINO, UNITO","FINANCIAL SUPPORT FROM THE UNIVERSITY OF TORINO IS GRATEFULLY ACKNOWLEDGED. WE ARE INDEBTED TO PROF. MARCO VINCENTI AND DR ALBERTO SALOMONE FOR THE IRMS ANALYSES AT THE CAD (ORBASSANO, TURIN).","AMARENGO W.L.F., PERRIN D.D., PURIFICATION OF LABORATORY CHEMICALS, (1998); BELTZ S.D., DOERING P.L., EFFICACY OF NUTRITIONAL SUPPLEMENTS USED BY ATHLETES, CLINICAL PHARMACOLOGY, 12, PP. 900-908, (1993); CHEN F., WANG Z., ZHAO G., LIAO X., CAI T., GUO L., ET AL., PURIFICATION PROCESS OF OCTACOSANOL EXTRACTS FROM RICE BRAN WAX BY MOLECULAR DISTILLATION, JOURNAL OF FOOD ENGINEERING, 79, PP. 63-68, (2007); COPLEN T.B., REPORTING OF STABLE HYDROGEN, CARBON, AND OXYGEN ISOTOPIC ABUNDANCES, PURE AND APPLIED CHEMISTRY, 66, PP. 273-276, (1994); COPLEN T.B., REPORTING OF STABLE HYDROGEN, CARBON, AND OXYGEN ISOTOPIC ABUNDANCES, GEOTHERMICS, 24, PP. 708-711, (1995); COPLEN T.B., BRAND W.A., GEHRE M., GRONING M., MEIJER H.A.J., TOMAN B., ET AL., AFTER TWO DECADES A SECOND ANCHOR FOR THE VPDB DELTA C-13 SCALE, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 20, PP. 3165-3166, (2006); CRAVOTTO G., A PROCESS FOR PREPARING LONG CHAIN SATURATED OR UNSATURATED OXYGENATED COMPOUNDS, (2005); CRAVOTTO G., BOFFA L., MANTEGNA S., AVOGADRO M., PEREGO P., CINTAS P., IMPROVED EXTRACTION OF NATURAL MATRICES UNDER HIGH-INTENSITY ULTRASOUND AND MICROWAVE, ALONE OR COMBINED, ULTRASONIC SONOCHEMISTRY, 15, PP. 898-902, (2008); CRAVOTTO G., CINTAS P., THE COMBINED USE OF MICROWAVES AND ULTRASOUND: NEW TOOLS IN PROCESS CHEMISTRY AND ORGANIC SYNTHESIS, CHEMISTRY: A EUROPEAN JOURNAL, 13, PP. 1902-1909, (2007); HERNA NDEZ F., ILLNAIT J., MA S.R., CASTANO G., FERNANDEZ L., GONZALEZ M., ET AL., EFFECTS OF POLICOSANOL ON SERUM LIPIDS AND LIPOPROTEINS IN HEALTHY VOLUNTEERS, CURRENT THERAPEUTIC RESEARCH, 51, PP. 568-575, (1992); HOUTZ R.L., RIES S.K., TOLBERT N.E., EFFECT OF TRIACONTANOL ON CHLAMYDOMONAS: I. STIMULATION OF GROWTH AND PHOTOSYNTHETIC CO2 ASSIMILATION, PLANT PHYSIOLOGY, 79, PP. 357-364, (1985); KABIR Y., KIMURA S., BIODISTRIBUTION AND METABOLISM OF ORALLY ADMINISTERED OCTACOSANOL IN RATS, ANNALS OF NUTRITIONAL AND METABOLISM, 37, PP. 33-38, (1993); KABIR Y., KIMURA S., DISTRIBUTION OF RADIOACTIVE OCTACOSANOL IN RESPONSE TO EXERCISE IN RATS, NAHRUNG, 38, PP. 373-377, (1994); KABIR Y., KIMURA S., TISSUE DISTRIBUTION OF (8-14C)-OCTACOSANOL IN LIVER AND MUSCLE OF RATS AFTER SERIAL ADMINISTRATION, ANNALS OF NUTRITIONAL AND METABOLISM, 39, PP. 279-284, (1995); KELLER S., GIMMLER F., JAHREIS G., OCTACOSANOL ADMINISTRATION TO HUMANS DECREASES NATURAL STEROL AND BILE ACID CONCENTRATION IN FAECES, LIPIDS, 43, PP. 109-115, (2008); MA S.R., POLICOSANOL, DRUGS FUTURE, 25, PP. 569-586, (2000); MENENDEZ R., SOTOLONGO V., FRAGA V., AMOR A.M., GONZE LEZ R., DEL RIO A., ET AL., PLASMA LEVELS AND TOTAL RADIOACTIVITY EXCRETION IN HEALTHY VOLUNTEERS AFTER ORAL 3HOCTACOSANOL ADMINISTRATION, REVISTA CENIC CIENCIAS BIOLOGICAS, 27, PP. 32-35, (1996); NORRIS F.H., DENYS E.H., FALLAT R.J., TRIAL OF OCTACOSANOL IN AMYOTROPHIC LATERAL SCLEROSIS, NEUROLOGY, 36, PP. 1264-1264, (1986); PALMISANO G., TAGLIAPIETRA S., BARGE A., BINELLO A., BOFFA L., CRAVOTTO G., EFFICIENT REGIOSELECTIVE OPENING OF EPOXIDES BY NUCLEOPHILES IN WATER UNDER SIMULTANEOUS ULTRASOUND/MICROWAVE IRRADIATION, SYNLETT, 13, PP. 2041-2044, (2007); SAINT-JOHN M., MC NAUGHTON L., OCTACOSANOL INGESTION AND ITS EFFECTS ON METABOLIC RESPONSES TO SUBMAXIMAL CYCLE ERGOMETRY, REACTION TIME AND CHEST AND GRIP STRENGTH, INTERNATIONAL CLINICAL NUTRITIONAL REVIEW, 6, PP. 81-87, (1986); SHIMURA S., HASEGAWA T., TAKANO S., SUZUKI T., STUDIES ON THE EFFECT OF OCTACOSANOL ON MOTOR ENDURANCE IN MICE, NUTRITIONAL REPORTS INTERNATIONAL, 36, PP. 1029-1036, (1987); SHO H., CHINEN I., FUKUDA N., EFFECTS OF OKINAWAN SUGAR CANE WAX AND FATTY ALCOHOL ON SERUM AND LIVER LIPIDS IN THE RAT, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 30, PP. 553-559, (1984); SIERRA R., GONZA LEZ V., MAGRANER J., VALIDATION OF A GAS CHROMATOGRAPHIC METHOD FOR DETERMINING FATTY ALCOHOLS THAT COMPOSE POLICOSANOL IN 10 MG FILM-COATED TABLETS, THE JOURNAL OF AOAC INTERNATIONAL, 85, PP. 563-566, (2002); SNIDER S.R., OCTACOSANOL IN PARKINSONISM, ANNALS OF NEUROLOGY, 16, PP. 723-723, (1984); VIOLA F., OLIARO S., BINELLO A., CRAVOTTO G., POLICOSANOL: UPDATING AND PERSPECTIVES, MEDITERRANEAN JOURNAL OF NUTRITIONAL AND METABOLISM, 1, PP. 77-83, (2008); VOY R., ILLICIT DRUGS AND THE ATHLETE, AMERICAN PHARMACY, 26, PP. 39-45, (1986); WANG M.F., LIAN H.Z., MAO L., ZHOU J.P., GONG H.J., QIAN B.Y., FANG Y., LI J., COMPARISON OF VARIOUS EXTRACTION METHODS FOR POLICOSANOL FROM RICE BRAN WAX AND ESTABLISHMENT OF CHROMATOGRAPHIC FINGERPRINT OF POLICOSANOL, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 55, PP. 5552-5558, (2007); WOOLLEY B.H., THE LATEST FADS TO INCREASE MUSCLE MASS AND ENERGY: A LOOK AT WHAT SOME ATHLETES ARE USING, POSTGRADUATE MEDICINE, 89, PP. 195-205, (1991)","G. CRAVOTTO; DIPARTIMENTO DI SCIENZA E TECNOLOGIA DEL FARMACO, UNIVERSITÀ DI TORINO, 10125 TORINO, ITALY; EMAIL: GIANCARLO.CRAVOTTO@UNITO.IT","","ENGLISH","NAT. PROD. RES.","ARTICLE","ISI","2-S2.0-77950121134","NAT PROD RES","UNIVERSITÀ DI TORINO;UNIVERSITÀ DI TORINO;UNIVERSITÀ DI TORINO;UNIVERSITÀ DI TORINO;UNIVERSITÀ DI TORINO;UNIVERSITÀ DI TORINO","NOTREPORTED;UNIVERSITÀ DI TORINO;NOTREPORTED",NA,"CRAVOTTO G, 2010, NAT PROD RES","CRAVOTTO G, 2010, NAT PROD RES"
"SHEN J;LUO F;LIN Q","SHEN, JUNJUN (57191926274); LUO, FEIJUN (23025317600); LIN, QINLU (57194683507)","POLICOSANOL EXTRACTION AND BIOLOGICAL FUNCTIONS",2019,"JOURNAL OF FUNCTIONAL FOODS","57","9",40,"10.1016/j.jff.2019.04.024","NATIONAL ENGINEERING LABORATORY FOR DEEP PROCESS OF RICE AND BYPRODUCTS, HUNAN KEY LABORATORY OF GRAIN-OIL DEEP PROCESS AND QUALITY CONTROL, HUNAN KEY LABORATORY OF PROCESSED FOOD FOR SPECIAL MEDICAL PURPOSE, COLLEGE OF FOOD SCIENCE AND ENGINEERING, CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY, CHANGSHA, 410004, HUNAN, CHINA, COLLEGE OF LIFE SCIENCE AND BIOTECHNOLOGY, CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY, CHANGSHA, 410004, HUNAN, CHINA;NATIONAL ENGINEERING LABORATORY FOR DEEP PROCESS OF RICE AND BYPRODUCTS, HUNAN KEY LABORATORY OF GRAIN-OIL DEEP PROCESS AND QUALITY CONTROL, HUNAN KEY LABORATORY OF PROCESSED FOOD FOR SPECIAL MEDICAL PURPOSE, COLLEGE OF FOOD SCIENCE AND ENGINEERING, CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY, CHANGSHA, 410004, HUNAN, CHINA;NATIONAL ENGINEERING LABORATORY FOR DEEP PROCESS OF RICE AND BYPRODUCTS, HUNAN KEY LABORATORY OF GRAIN-OIL DEEP PROCESS AND QUALITY CONTROL, HUNAN KEY LABORATORY OF PROCESSED FOOD FOR SPECIAL MEDICAL PURPOSE, COLLEGE OF FOOD SCIENCE AND ENGINEERING, CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY, CHANGSHA, 410004, HUNAN, CHINA","POLICOSANOL IS WIDELY DISTRIBUTED NATURALLY AND CAN BE ISOLATED AND PURIFIED FROM RICE BRAN, SUGARCANE, APPLES, GRAPES ETC. DUE TO ITS FUNCTIONAL SIGNIFICANCE AND EASE OF BIOAVAILABILITY, TECHNIQUES FOR THE EXTRACTION OF POLICOSANOL ARE OF GREAT SIGNIFICANCE TO INVESTIGATORS, OF WHICH SAPONIFICATION, SOLVENT EXTRACTION, TRANSESTERIFICATION, MOLECULAR DISTILLATION, SUPERCRITICAL CARBON DIOXIDE EXTRACTION, ULTRASONIC-ASSISTED EXTRACTION AND OTHER EXTRACTION METHODS ARE EVALUATED. POLICOSANOL HAS BEEN USUALLY APPLIED IN FUNCTIONAL FOODS BECAUSE IT HAS MULTIPLE HEALTH-IMPROVING PROPERTIES, INCLUDING THE LOWERING OF LIPIDS, ANTI-AGING, TISSUE REGENERATION, CYTO-, LIVER, CARDIOVASCULAR AND CEREBROVASCULAR PROTECTION, AND PROTECTION AGAINST DIABETES, HYPERCHOLESTEROLEMIA, PARKINSON'S DISEASE, INFLAMMATION, ULCERS AND CANCER. ADDITIONALLY, THE SIGNALING PATHWAYS AMPK, MAPK AND PI3K/AKT INVOLVED IN ITS EFFECTS ARE INVESTIGATED. THIS REVIEW COMPILED THE MOST INTERESTING REFERENCES FOR SCIENTIFICS ENGAGED IN POLICOSANOL HEALTH-IMPROVING EFFECTS, INCLUDING EXTRACTION PROCEDURES. TO SUM UP, IT WILL HELP TO DEVELOP ANCILLARY DRUGS AND FUNCTIONAL FOODS IN THE FUTURE. © 2019 ELSEVIER LTD","BIOAVAILABILITY; DIETARY SUPPLEMENTATION; EXTRACTION METHODS; FUNCTIONAL FOODS; HEALTH-IMPROVING ACTIVITIES; POLICOSANOL","","2011 COLLABORATIVE INNOVATION CENTER OF HUNAN PROVINCE, (448); KEY RESEARCH AND DEVELOP PLAN PROJECT OF HUNAN PROVINCE, (2017SK2190); NATURAL SCIENCE FOUNDATION OF HUNAN PROVINCE, (2017JJ3528, 2018JJ2672); PROGRAM FOR SCIENCE & TECHNOLOGY INNOVATION TALENTS OF HUNAN PROVINCE, (2017TP1021, KC1704007); EDUCATION DEPARTMENT OF HUNAN PROVINCE, (13A124); EDUCATION DEPARTMENT OF HUNAN PROVINCE; NATURAL SCIENCE FOUNDATION OF HUNAN PROVINCE","FUNDING TEXT 1: THIS WORK WAS SUPPORTED BY THE PROJECT “2011 COLLABORATIVE INNOVATION CENTER OF HUNAN PROVINCE” (2013, NO. 448), THE KEY PROJECT OF THE EDUCATION DEPARTMENT OF HUNAN PROVINCE (NO. 13A124), THE KEY RESEARCH AND DEVELOP PLAN PROJECT OF HUNAN PROVINCE (2017SK2190), NATURAL SCIENCE FOUNDATION OF HUNAN PROVINCE (2018JJ2672 AND 2017JJ3528), PROGRAM FOR SCIENCE & TECHNOLOGY INNOVATION TALENTS OF HUNAN PROVINCE (2017TP1021; KC1704007).; FUNDING TEXT 2: THIS WORK WAS SUPPORTED BY THE PROJECT “ 2011 COLLABORATIVE INNOVATION CENTER OF HUNAN PROVINCE ” (2013, NO. 448 ), THE KEY PROJECT OF THE EDUCATION DEPARTMENT OF HUNAN PROVINCE (NO. 13A124 ), THE KEY RESEARCH AND DEVELOP PLAN PROJECT OF HUNAN PROVINCE ( 2017SK2190 ), NATURAL SCIENCE FOUNDATION OF HUNAN PROVINCE ( 2018JJ2672 AND 2017JJ3528 ), PROGRAM FOR SCIENCE & TECHNOLOGY INNOVATION TALENTS OF HUNAN PROVINCE ( 2017TP1021 ; KC1704007 ).","AFFUSO F., MERCURIO V., RUVOLO A., PIROZZI C., MICILLO F., CARLOMAGNO G., ET AL., A NUTRACEUTICAL COMBINATION IMPROVES INSULIN SENSITIVITY IN PATIENTS WITH METABOLIC SYNDROME, WORLD JOURNAL OF CARDIOLOGY, 4, PP. 77-83, (2012); AFFUSO F., RUVOLO A., MICILLO F., SACCA L., FAZIO S., EFFECTS OF A NUTRACEUTICAL COMBINATION (BERBERINE, RED YEAST RICE AND POLICOSANOLS) ON LIPID LEVELS AND ENDOTHELIAL FUNCTION RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY, NUTRITION METABABOLISM AND CARDIOVASCULAR DISEASES, 9, PP. 656-661, (2010); AFINISHA DEEPAM L.S., ARUMUGHAN C., JOURNAL OF OLEO SCIENCE, 61, PP. 241-247, (2012); AHSAN H., AHAD A., SIDDIQUI W.A., A REVIEW OF CHARACTERIZATION OF TOCOTRIENOLS FROM PLANT OILS AND FOODS, JOURNAL OF CHEMICAL BIOLOGY, 8, PP. 45-59, (2015); ARRUZAZABALA M.L., CARBAJAL D., MAS R., MOLINA V., VALDES S., LAGUNA A., CHOLESTEROL-LOWERING EFFECTS OF POLICOSANOL IN RABBITS, BIOLOGICAL RESEARCH, 27, PP. 205-208, (1994); ARRUZAZABALA M.L., MOLINA V., MAS R., FERNANDEZ L., CARBAJAL D., VALDES S., ET AL., ANTIPLATELET EFFECTS OF POLICOSANOL (20 AND 40 MG/DAY) IN HEALTHY VOLUNTEERS AND DYSLIPIDAEMIC PATIENTS, CLINICAL AND EXPERIMENTAL PHARMACOLOGY & PHYSIOLOGY, 29, PP. 891-897, (2002); ATTARD T.M., MCELROY C.R., GAMMONS R.J., SLATTERY J.M., SUPANCHAIYAMAT N., SUPERCRITICAL CO<SUB>2</SUB> EXTRACTION AS AN EFFECTIVE PRETREATMENT STEP FOR WAX EXTRACTION IN A MISCANTHUS BIOREFINERY, SUSTAINABLE CHEMISTRY & ENGINEERING, 4, PP. 5979-5988, (2016); BANERJEE S., GHOSHAL S., PORTER T.D., ACTIVATION OF AMP-KINASE BY POLICOSANOL REQUIRES PEROXISOMAL METABOLISM, LIPIDS, 46, PP. 311-321, (2011); CARBAJAL D., MOLINA V., VALDES S., ARRUZAZABALA L., MAS R., ANTI-ULCER ACTIVITY OF HIGHER PRIMARY ALCOHOLS OF BEESWAX, THE JOURNAL OF PHARMACY AND PHARMACOLOGY, 47, PP. 731-733, (1995); CASTANO G., FERNANDEZ L., MAS R., ILLNAIT J., MESA M., FERNANDEZ J.C., COMPARISON OF THE EFFECTS OF POLICOSANOL AND ATORVASTATIN ON LIPID PROFILE AND PLATELET AGGREGATION IN PATIENTS WITH DYSLIPIDAEMIA AND TYPE 2 DIABETES MELLITUS, CLINICAL DRUG INVESTIGATION, 23, PP. 639-650, (2003); CASTANO G., MAS R., FERNANDEZ L., ILLNAIT J., GAMEZ R., ALVAREZ E., EFFECTS OF POLICOSANOL 20 VERSUS 40 MG/DAY IN THE TREATMENT OF PATIENTS WITH TYPE II HYPERCHOLESTEROLEMIA: A 6-MONTH DOUBLE-BLIND STUDY, INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY RESEARCH, 21, PP. 43-57, (2001); CASTANO G., MENENDEZ R., MAS R., AMOR A., FERNANDEZ J.L., GONZALEZ R.L., ET AL., EFFECTS OF POLICOSANOL AND LOVASTATINON LIPID PROFILE AND LIPID PEROXIDATION IN PATIENTS WITH DYSLIPIDEMIA ASSOCIATED WITH TYPE 2 DIABETES MELLITUS, INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY RESEARCH, 22, PP. 89-99, (2002); CHEN F., CAI T., ZHAO G., LIAO X., GUO L., HU X., OPTIMIZING CONDITIONS FOR THE PURIFICATION OF CRUDE OCTACOSANOL EXTRACT FROM RICE BRAN WAX BY MOLECULAR DISTILLATION ANALYZED USING RESPONSE SURFACE METHODOLOGY, JOURNAL OF FOOD ENGINEERING, 70, PP. 47-53, (2005); CHEN F., CAI T., ZHAO G., LIAO X., GUO L., HU X., PURIFICATION PROCESS OF OCTACOSANOL EXTRACTS FROM RICE BRAN WAX BY MOLECULAR DISTILLATION, JOURNAL OF FOOD ENGINEERING, 79, PP. 63-68, (2007); CHO K.H., KIM S.J., YADAV D., KIM J.Y., KIM J.R., CONSUMPTION OF CUBAN POLICOSANOL IMPROVES BLOOD PRESSURE AND LIPID PROFILE VIA ENHANCEMENT OF HDL FUNCTIONALITY IN HEALTHY WOMEN SUBJECTS: RANDOMIZED, DOUBLE-BLINDED, AND PLACEBO-CONTROLLED STUDY, OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, (2018); CHO K.H., YADAV D., KIM S.J., KIM J.R., BLOOD PRESSURE LOWERING EFFECT OF CUBAN POLICOSANOL IS ACCOMPANIED BY IMPROVEMENT OF HEPATIC INFLAMMATION, LIPOPROTEIN PROFILE, AND HDL QUALITY IN SPONTANEOUSLY HYPERTENSIVE RATS, MOLECULES, 3, (2018); CHU B., QU Y., HUANG Y., ZHANG L., CHEN X., LONG C., ET AL., PEG-DERIVATIZED OCTACOSANOL AS MICELLAR CARRIER FOR PACLITAXEL DELIVERY, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 500, PP. 345-359, (2016); CICERO A.F., BRANCALEONI M., LAGHI L., DONATI F., MINO M., ANTIHYPERLIPIDAEMIC EFFECT OF A MONASCUS PURPUREUS BRAND DIETARY SUPPLEMENT ON A LARGE SAMPLE OF SUBJECTS AT LOW RISK FOR CARDIOVASCULAR DISEASE: A PILOT STUDY, COMPLEMENTARY THERAPIES IN MEDICINE, 13, PP. 273-278, (2005); CRAVOTTO G., BINELLO A., MERIZZI G., AVOGADRO M., IMPROVING SOLVENT-FREE EXTRACTION OF POLICOSANOL FROM RICE BRAN BY HIGH-INTENSITY ULTRASOUND TREATMENT, EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 106, PP. 147-151, (2004); DE OLIVEIRA A.M., CONSERVA L.M., DE SOUZA FERRO J.N., DE ALMEIDA BRITO F., LYRA LEMOS R.P., BARRETO E., ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF OCTACOSANOL FROM THE LEAVES OF SABICEA GRISEA VAR. GRISEA IN MICE, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 13, PP. 1598-1611, (2012); DUNFORD N.T., EDWARDS J., NUTRITIONAL BIOACTIVE COMPONENTS OF WHEAT STRAW AS AFFECTED BY GENOTYPE AND ENVIRONMENT, BIORESOURCE TECHNNOLOGY, 101, PP. 422-425, (2010); DUNFORD N.T., IRMAK S., JONNALA R., PRESSURISED SOLVENT EXTRACTION OF POLICOSANOL FROM WHEAT STRAW, GERM AND BRAN, FOOD CHEMISTRY, 119, PP. 1246-1249, (2010); ELSEWEIDY M.M., AMIN R.S., ATTEIA H.H., EL-ZEIKY R.R., AL-GABRI N.A., NEW INSIGHT ON A COMBINATION OF POLICOSANOL AND 10-DEHYDROGINGERDIONE PHYTOCHEMICALS AS INHIBITORS FOR PLATELET ACTIVATION BIOMARKERS AND ATHEROGENICITY RISK IN DYSLIPIDEMIC RABBITS: ROLE OF CETP AND PCSK9 INHIBITION, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, (2018); FERNANDEZ-ARCHE A., MARQUEZ-MARTIN A., VAZQUEZ R., PERONA J., TERENCIO C., PEREZ-CAMINO C., ET AL., LONG-CHAIN FATTY ALCOHOLS FROM POMACE OLIVE OIL MODULATE THE RELEASE OF PROINFLAMMATORY MEDIATORS, THE JOURNAL OF NUTRITION BIOCHEMISTRY, 20, PP. 155-162, (2009); FRAGA V., MENENDEZ R., AMOR A.M., GONZALEZ R.M., JIMENEZ S., MAS R., EFFECT OF POLICOSANOL ON IN VITRO AND IN VIVO RAT LIVER MICROSOMAL LIPID PEROXIDATION, ARCHIVES MEDICAL RESEARCH, 28, PP. 355-360, (1997); GAO W., LIU D., SU S., HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY FOR QUANTIFICATION OF 1-OCTACOSANOL IN ANTARCTIC KRILL (EUPHAUSIA SUPERBA DANA), JOURNAL OF CHROMATOGRAPHIC SCIENCE, 53, PP. 811-815, (2015); GIUFFRE A.M., CAPOCASALE M., POLICOSANOL IN TOMATO (SOLANUM LYCOPERSICUM L.) SEED OIL: THE EFFECT OF CULTIVAR, JOURNAL OF OLEO SCIENCE, 64, PP. 625-631, (2015); GONG J., QIN X., YUAN F., HU M., CHEN G., FANG K., ET AL., EFFICACY AND SAFETY OF SUGARCANE POLICOSANOL ON DYSLIPIDEMIA: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS, MOLECULAR NUTROTION & FOOD RESEARCH, 62, PP. 1700280-1700292, (2018); GOUNI-BERTHOLD I., BERTHOLD H.K., POLICOSANOL: CLINICAL PHARMACOLOGY AND THERAPEUTIC SIGNIFICANCE OF A NEW LIPID-LOWERING AGENT, AMERICAN HEART JOURNAL, 143, PP. 356-365, (2002); GUARDAMAGNA O., ABELLO F., BARACCO V., STASIOWSKA B., MARTINO F., THE TREATMENT OF HYPERCHOLESTEROLEMIC CHILDREN: EFFICACY AND SAFETY OF A COMBINATION OF RED YEAST RICE EXTRACT AND POLICOSANOLS, NUTRITION, METABOLISM, CARDIOVASCULAR DISEASES, 21, PP. 424-429, (2011); GUO T., LIN Q., LI X., NIE Y., WANG L., SHI L., ET AL., OCTACOSANOL ATTENUATES INFLAMMATION IN BOTH RAW264.7 MACROPHAGES AND A MOUSE MODEL OF COLITIS, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 5, PP. 3647-3658, (2017); GUPTA S.S., GHOSH M., OCTACOSANOL EDUCES PHYSICO-CHEMICAL ATTRIBUTES, RELEASE AND BIOAVAILABILITY AS MODIFIED NANOCRYSTALS, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 119, PP. 201-214, (2017); HARGROVE J.L., GREENSPAN P., HARTLE D.K., NUTRITIONAL SIGNIFICANCE AND METABOLISM OF VERY LONG CHAIN FATTY ALCOHOLS AND ACIDS FROM DIETARY WAXES, EXPERIMENTAL BIOLOGY AND MEDICINE, 229, PP. 215-226, (2004); HARRABI S., FERCHICHI A., BACHELI A., FELLAH H., POLICOSANOL COMPOSITION, ANTIOXIDANT AND ANTI-ARTHRITIC ACTIVITIES OF MILK THISTLE (SILYBIUM MARIANUM L.) OIL AT DIFFERENT SEED MATURITY STAGES, LIPIDS AND HEALTH DISEASES, 17, (2018); HARRINGTON A.W., LEINER B., BLECHSCHMITT C., AREVALO J.C., LEE R., MORL K., ET AL., SECRETED PRONGF IS A PATHOPHYSIOLOGICAL DEATH-INDUCING LIGAND AFTER ADULT CNS INJURY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, PP. 6226-6230, (2004); HERNANDEZ F., ILLNAIT J., MAS R., CASTANO G., FERNANDEZ L., GONZALEZ M., ET AL., EFFECT OF POLICOSANOL ON SERUM LIPIDS AND LIPOPROTEINS IN HEALTHY VOLUNTEERS, CURRENT THERAPEUTICAL RESEARCH, 51, PP. 568-575, (1992); HERRERO M., CIFUENTES A., IBANEZ E., SUB- AND SUPERCRITICAL FLUID EXTRACTION OF FUNCTIONAL INGREDIENTS FROM DIFFERENT NATURAL SOURCES: PLANTS, FOOD-BY-PRODUCTS, ALGAE AND MICROALGAE, A REVIEW, FOOD CHEMISTRY, 98, PP. 136-148, (2006); HSU C.Y., SHIH H.Y., CHANG Y.C., HUANG Z.L., TSAI M.J., CHIA Y., ET AL., THE BENEFICIAL EFFECTS OF TETRACOSANOL ON INSULIN-RESISTANCE BY INSULIN RECEPTOR KINASE SENSIBILIZATION, JOURNAL OF FUNCTIONAL FOODS, 14, PP. 174-182, (2015); HUNTER P.M., HEGELE R.A., FUNCTIONAL FOODS AND DIETARY SUPPLEMENTS FOR THE MANAGEMENT OF DYSLIPIDAEMIA, NATURE REVIEWS ENDOCRINOLOGY, 13, PP. 278-288, (2017); IRMAK S., DUNFORD N.T., POLICOSANOL CONTENTS AND COMPOSITIONS OF WHEAT VARIETIES, JOURNAL OF AGRICULTRAL AND FOOD CHEMISTRY, 53, PP. 5583-5586, (2005); IRMAK S., DUNFORD N.T., MILLIGAN J., POLICOSANOL CONTENTS OF BEESWAX, SUGAR CANE AND WHEAT EXTRACTS, FOOD CHEMISTRY, 95, PP. 312-318, (2006); ISHAKA A., UMAR I.M., MAHAMUD R., ZUKI A.B., MAZNAH I., CHARACTERIZATION OF RICE BRAN WAX POLICOSANOL AND ITS NANOEMULSION FORMULATION, INTERNATIONAL JOURNAL OF NANOMEDICINE, 9, PP. 2261-2269, (2014); IZZO R., DE SIMONE G., GIUDICE R., CHINALI M., TRIMARCO V., DE LUCA N., ET AL., EFFECTS OF NUTRACEUTICALS ON PREVALENCE OF METABOLIC SYNDROME AND ON CALCULATED FRAMINGHAM RISK SCORE IN INDIVIDUALS WITH DYSLIPIDEMIA, JOURNAL OF HYPERTENSION, 28, PP. 1482-1487, (2010); JACKSON M.A., ELLER F.J., ISOLATION OF LONG-CHAIN ALIPHATIC ALCOHOLS FROM BEESWAX USING LIPASE-CATALYZED METHANOLYSIS IN SUPERCRITICAL CARBON DIOXIDE, THE JOURNAL OF SUPERCRITICAL FLUIDS, 37, PP. 173-177, (2006); JUNG D.M., YOON S.H., JUNG M.Y., CHEMICAL PROPERTIES AND OXIDATIVE STABILITY OF PERILLA OILS OBTAINED FROM ROASTED PERILLA SEEDS AS AFFECTED BY EXTRACTION METHODS, JOURNAL OF FOOD SCIENCE, 77, PP. C1249-C1255, (2012); KABIR Y., KIMURA S., BIODISTRIBUTION AND METABOLISM OF ORALLY ADMINISTERED OCTACOSANOL IN RATS, ANNALS OF NUTRITION AND METABOLISM, 37, PP. 33-38, (1993); KABIR Y., KIMURA S., TISSUE DISTRIBUTION OF (8–14C)-OCTACOSANOL IN LIVER AND MUSCLE OF RATS AFTER SERIAL ADMINISTRATION, ANNALS OF NUTRITION AND METABOLISM, 39, PP. 279-284, (1995); KATO S., KARINO K., HASEGAWA S., NAGASAWA J., NAGASAKI A., EGUCHI M., ET AL., OCTACOSANOL AFFECTS LIPID METABOLISM IN RATS FED ON A HIGH-FAT DIET, THE BRITISH JOURNAL OF NUTRITION, 73, PP. 433-441, (1995); KAUSHIK M.K., ARITAKE K., TAKEUCHI A., YANAGISAWA M., URADE Y., OCTACOSANOL RESTORES STRESS-AFFECTED SLEEP IN MICE BY ALLEVIATING STRESS, SCIENTIFIC REPORTS, 7, PP. 8892-8899, (2017); KIM H., PARK S., HAN D.S., PARK T., OCTACOSANOL SUPPLEMENTATION INCREASES RUNNING ENDURANCE TIME AND IMPROVES BIOCHEMICAL PARAMETERS AFTER EXHAUSTION IN TRAINED RATS, JOURNAL OF MEDICINAL FOOD, 6, PP. 345-351, (2003); KIM S.J., YADAV D., PARK H.J., KIM J.R., CHO K.H., LONG-TERM CONSUMPTION OF CUBAN POLICOSANOL LOWERS CENTRAL AND BRACHIAL BLOOD PRESSURE AND IMPROVES LIPID PROFILE WITH ENHANCEMENT OF LIPOPROTEIN PROPERTIES IN HEALTHY KOREAN PARTICIPANTS, FRONTIERS IN PHYSIOLOGY, 9, (2018); KOUBAA M., ROSELLO-SOTO E., SIC-ZLABUR J., REZEK-JAMBRAK A., BRNCIC M., GRIMI N., ET AL., CURRENT AND NEW INSIGHTS IN THE SUSTAINABLE AND GREEN RECOVERY OF NUTRITIONALLY VALUABLE COMPOUNDS FROM STEVIA REBAUDIANA BERTONI, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 63, PP. 6835-6846, (2015); LEE J.H., JIA Y., THACH T.T., HAN Y., KIM B., WU C., ET AL., HEXACOSANOL REDUCES PLASMA AND HEPATIC CHOLESTEROL BY ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE AND SUPPRESSION OF STEROL REGULATORY ELEMENT-BINDING PROTEIN-2 IN HEPG2 AND C57BL/6J MICE, NUTRION RESEARCH, 43, PP. 89-99, (2017); LEE R., KERMANI P., TENG K.K., HEMPSTEAD B.L., REGULATION OF CELL SURVIVAL BY SECRETEDPRONEUROTROPHINS, SCIENCE, 294, PP. 1945-1948, (2001); LEE E.Y., YOO J.A., LIM S.M., CHO K.H., ANTI-AGING AND TISSUE REGENERATION ABILITY OF POLICOSANOL ALONG WITH LIPID-LOWERING EFFECT IN HYPERLIPIDEMIC ZEBRAFISH VIA ENHANCEMENT OF HIGH-DENSITY LIPOPROTEIN FUNCTIONALITY, REJUVENATION RESEARCH, 19, PP. 149-158, (2016); LI J., SUN D., QIAN L., LIU Y., SUBCRITICAL BUTANE EXTRACTION OF WHEAT GERM OIL AND ITS DEACIDIFICATION BY MOLECULAR DISTILLATION, MOLECULES, 21, (2016); LI Q., THOMSON A.B., CLANDININ M.T., CHOLESTEROL ESTER AND FREE FATTY ACIDS ARE MODULATED BY POLICOSANOL IN CACO-2 INTESTINAL CELLS, JOURNAL OF THE AMERICAN COLLEGE OF NUTROTION, 30, PP. 201-209, (2011); LIM S.M., YOO J.A., LEE E.Y., CHO K.H., ENHANCEMENT OF HIGH-DENSITY LIPOPROTEIN CHOLESTEROL FUNCTIONS BY ENCAPSULATION OF POLICOSANOL EXERTS ANTI-SENESCENCE AND TISSUE REGENERATION EFFECTS VIA IMPROVEMENT OF ANTI-GLYCATION, ANTI-APOPTOSIS, AND CHOLESTERYL ESTER TRANSFER INHIBITION, REJUVENATION RESEARCH, 19, PP. 59-70, (2016); LIN S.R., FU Y.S., TSAI M.J., CHENG H., WENG C.F., NATURAL COMPOUNDS FROM HERBS THAT CAN POTENTIALLY EXECUTE AS AUTOPHAGY INDUCERS FOR CANCER THERAPY, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCE, 18, (2017); LIU Y., YU J., WANG X., EXTRACTION OF POLICOSANOLS FROM HYDROLYSED RICE BRAN WAX BY HIGH-INTENSITY ULTRASOUND, INTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, 43, PP. 763-769, (2008); LIU Y.W., ZUO P.Y., ZHA X.N., CHEN X.L., ZHANG R., HE X.X., ET AL., OCTACOSANOL ENHANCES THE PROLIFERATION AND MIGRATION OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS VIA ACTIVATION OF THE PI3K/AKT AND MAPK/ERK PATHWAYS, LIPIDS, 50, PP. 241-251, (2015); LONG L., GAO M.Z., PENG K., SUN J., WANG X.S., EFFECTS OF OCTACOSANOL EXTRACTED FROM RICE BRAN ON PRODUCTION PERFORMANCE AND BLOOD PARAMETERS IN WEANLING PIGLETS, JOURNAL OF CHINESE CEREALS OILS ASSOCIATION, 30, PP. 94-100, (2015); LONG L., WU S.G., SUN J., WANG J., ZHANG H.J., QI G.H., EFFECTS OF OCTACOSANOL EXTRACTED FROM RICE BRAN ON BLOOD HORMONE LEVELS AND GENE EXPRESSIONS OF GLUCOSE TRANSPORTER PROTEIN-4 AND ADENOSINE MONOPHOSPHATE PROTEIN KINASE IN WEANING PIGLETS, ANIMAL NUTRITION, 4, PP. 293-298, (2015); LORENZ P., BERGER M., BERTRAMS J., WENDE K., WENZEL K., NATURAL WAX CONSTITUENTS OF A SUPERCRITICAL FLUID CO<SUB>2</SUB> EXTRACT FROM QUINCE (CYDONIA OBLONGA MILL.) POMACE, ANALYTIC BIOANALYTICAL CHEMISTRY, 391, PP. 633-646, (2008); LUKASHEVICH V., DAVIDSON M.H., MOREINES J., BERLIN R.G., BEESWAX POLICOSANOL FAILED TO DEMONSTRATE LIPID-ALTERING EFFECTS IN WELL-CONTROLLED CLINICAL TRIALS, CIRCULATION, 114, (2006); LUQUE-GARCIA J.L., LUQUE DE CASTRO M.D., ULTRASOUND: A POWERFUL TOOL FOR LEACHING, TRENDS IN ANALYTICAL CHEMISTRY, 22, PP. 41-47, (2003); MA J., MA L., ZHANG H., ZHANG Z., WANG Y., LI K., ET AL., POLICOSANOL FABRICATION FROM INSECT WAX AND OPTIMIZATION BY RESPONSE SURFACE METHODOLOGY, PLOS ONE, 13, (2018); MARAZZI G., CACCIOTTI L., PELLICCIA F., IAIA L., VOLTERRANI M., CAMINITI G., LONG-TERM EFFECTS OF NUTRACEUTICALS (BERBERINE, RED YEAST RICE, POLICOSANOL) IN ELDERLY HYPERCHOLESTEROLEMIC PATIENTS, ADVANCES IN THERAPY, 28, PP. 1105-1113, (2011); MARAZZI G., PELLICCIA F., CAMPOLONGO G., QUATTRINO S., CACCIOTTI L., VOLTERRANI M., ET AL., USEFULNESS OF NUTRACEUTICALS (ARMOLIPID PLUS) VERSUS EZETIMIBE AND COMBINATION IN STATIN-INTOLERANT PATIENTS WITH DYSLIPIDEMIA WITH CORONARY HEART DISEASE, THE AMERICAN JOURNAL OF CARDIOLOGY, 116, PP. 1798-1801, (2015); MARCHITTO N., SINDONA F., FABRIZIO A., MAUTI M., ANDREOZZI S., DALMASO S., EFFECT OF NEW NUTRACEUTICAL FORMULATION WITH POLICOSANOL, BERBERINE, RED YEAST RICE, CASSIA NOMAME, ASTAXANTINE AND Q10 COENZYME IN PATIENTS WITH LOW-MODERATE DYSLIPIDEMIA ASSOCIATED WITH INTOLERANCE TO STATINS AND METABOLIC SYNDROME, MINERVA CARDIOANGIOLOGICA, 66, PP. 124-125, (2018); MARINANGELI C.P., JONES P.J., KASSIS A.N., ESKIN M.N., POLICOSANOLS AS NUTRACEUTICALS: FACT OR FICTION, CRITICAL REVIEW OF FOOD SCIENCE AND NUTRITION, 50, PP. 259-267, (2010); MAS R., CASTANO G., ILLNAIT J., FERNANDEZ L., FERNANDEZ J., ALEMAN C., EFFECTS OF POLICOSANOL IN PATIENTS WITH TYPE II HYPERCHOLESTEROLEMIA AND ADDITIONAL CORONARY RISK FACTORS, CLINICAL PHARMACOLOGY AND THERAPEUTICS, 65, PP. 439-447, (1999); MAZZA A., LENTI S., SCHIAVON L., ZUIN M., D'AVINO M., RAMAZZINA E., NUTRACEUTICALS FOR SERUM LIPID AND BLOOD PRESSURE CONTROL IN HYPERTENSIVE AND HYPERCHOLESTEROLEMIC SUBJECTS AT LOW CARDIOVASCULAR RISK, ADVANCES IN THERAPY, 32, PP. 680-690, (2015); MOLINA V., ARRUZAZABALA M.L., CARBAJAL D., VALDES S., NOA M., EFFECT OF POLICOSANOL ON CEREBRALISCHEMIA IN MONGOLIAN GERBILS, BRAZILIAN JOURNAL OF MEDICAL BIOLOGICAL RESEARCH, 32, PP. 1269-1276, (1999); MOLINA V., RAVELO Y., NOA M., MAS R., PEREZ Y., THERAPEUTIC EFFECTS OF POLICOSANOL AND ATORVASTATIN AGAINST GLOBAL BRAIN ISCHAEMIA-REPERFUSION INJURY IN GERBILS, INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 75, PP. 635-641, (2013); MONTSERRAT-DE LA PAZ S., GARCIA-GIMENEZ M.D., ANGEL-MARTIN M., PEREZ-CAMINO M.C., FERNANDEZ A.A., LONG-CHAIN FATTY ALCOHOLS FROM EVENING PRIMROSE OIL INHIBIT THE INFLAMMATORY RESPONSEIN MURINE PERITONEAL MACROPHAGES, JOURNAL OF ETHNOPHARMACOLOGY, 151, PP. 131-136, (2014); NOA M., HERRERA M., MAGRANER J., MAS R., FRAGA V., MENENDEZ R., EFFECT OF POLICOSANOLON ISOPRENALINE-INDUCED MYOCARDIAL NECROSIS IN RATS, THE JOURNAL OF PHARMACY AND PHARMACOLOGY, 46, PP. 282-285, (1994); NOA M., MAS R., LARIOT C., PROTECTIVE EFFECT OF POLICOSANOLON ENDOTHELIUMAND INTIMAL THICKNESS INDUCED BY FORCEPS IN RABBITS, JOURNAL OF MEDICINAL FOOD, 10, PP. 452-459, (2007); NOA M., MENDOZA S., MAS R., MENDOZA N., EFFECT OF POLICOSANOL ON CARBON TETRACHLORIDE-INDUCEDACUTE LIVER DAMAGE IN SPRAGUE-DAWLEY RATS, DRUGS IN R & D, 4, PP. 29-35, (2003); NYKJAER A., LEE R., TENG K.K., JANSEN P., MADSEN P., NIELSEN M.S., ET AL., SORTILIN IS ESSENTIAL FOR PRONGF-INDUCED NEURONAL CELL DEATH, NATURE, 427, PP. 843-848, (2004); OHTA Y., OHASHI K., MATSURA T., TOKUNAGA K., KITAGAWA A., YAMADA K., OCTACOSANOL ATTENUATES DISRUPTED HEPATIC REACTIVE OXYGEN SPECIES METABOLISM ASSOCIATED WITH ACUTE LIVER INJURY PROGRESSION IN RATS INTOXICATED WITH CARBON TETRACHLORIDE, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 42, PP. 118-125, (2008); OLIARO-BOSSO S., CALCIO GAUDINO E., MANTEGNA S., GIRAUDO E., MEDA C., VIOLA F., ET AL., REGULATION OF HMG-COA REDUCTASE ACTIVITY BY POLICOSANOL AND OCTACOSADIENOL, A NEW SYNTHETIC ANALOGUE OF OCTACOSANOL, LIPIDS, 44, PP. 907-916, (2009); OROZCO-SOLANO M., RUIZ-JIMENEZ J., LUQUE DE CASTRO M.D., CHARACTERIZATION OF FATTY ALCOHOL AND STEROL FRACTIONS IN OLIVE TREE, JOURNAL OF AGRICULTURE AND FOOD CHEMISTRY, 58, PP. 7539-7546, (2010); OU S., ZHAO J., WANG Y., TIAN Y., WANG J., PREPARATION OF OCTACOSANOL FROM FILTER MUD PRODUCED AFTER SUGARCANE JUICE CLARIFICATION, LWT-FOOD SCIENCE AND TECHNOLOGY, 45, PP. 295-298, (2012); PASHA I., SAEED F., WAQAS K., ANJUM F.M., ARSHAD M.U., NUTRACEUTICAL AND FUNCTIONAL SCENARIO OF WHEAT STRAW, CRITICAL REVIEWS OF FOOD SCIENCE AND NUTRITION, 53, PP. 287-295, (2013); PENG K., LONG L., WANG Y., WANG S., EFFECTS OF OCTACOSANOL EXTRACTED FROM RICE BRAN ON THE LAYING PERFORMANCE, EGG QUALITY AND BLOOD METABOLITES OF LAYING HENS, ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 4, PP. 293-298, (2015); PIRRO M., VETRANI C., BIANCHI C., MANNARINO M.R., BERNINI F., RIVELLESE A.A., JOINT POSITION STATEMENT ON “NUTRACEUTICALS FOR THE TREATMENT OF HYPERCHOLESTEROLEMIA” OF THE ITALIAN SOCIETY OF DIABETOLOGY (SID) AND OF THE ITALIAN SOCIETY FOR THE STUDY OF ARTERIOSCLEROSIS (SISA), NUTRITION, METABOLISM AND CARDIOVASCULAR DISEASE, 27, PP. 2-17, (2017); PISCIOTTA L., BELLOCCHIO A., BERTOLINI S., NUTRACEUTICAL PILL CONTAINING BERBERINE VERSUS EZETIMIBE ON PLASMA LIPID PATTERN IN HYPERCHOLESTEROLEMIC SUBJECTS AND ITS ADDITIVE EFFECT IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA ON STABLE CHOLESTEROL-LOWERING TREATMENT, LIPIDS IN HEALTH AND DISEASE, 11, (2012); PRADO J.M., PRADO G.H.C., MEIRELES M.A.A., SCALE-UP STUDY OF SUPERCRITICAL FLUID EXTRACTION PROCESS FOR CLOVE AND SUGARCANE RESIDUE, JOURNAL OF SUPERCRITICAL FLUIDS, 56, PP. 231-237, (2011); RAVELO Y., MOLINA V., CARBAJAL D., FERNANDEZ L., FERNANDEZ J.C., ARRUZAZABALA M.L., EVALUATION OF ANTI-INFLAMMATORY AND ANTINOCICEPTIVE EFFECTS OF D-002 (BEESWAX ALCOHOLS), JOURNAL OF NATURAL MEDICINE, 65, PP. 330-335, (2011); RODRIGUES M.J., CUSTODIO L., LOPES A., OLIVEIRA M., NENG N.R., NOGUEIRA J.M., ET AL., UNLOCKING THE IN VITRO ANTI-INFLAMMATORY AND ANTIDIABETIC POTENTIAL OF POLYGONUM MARITIMUM, PHARMACEUTICAL BIOLOGY, 55, PP. 1348-1357, (2017); ROSELLO-SOTO E., KOUBAA M., MOUBARIK A., LOPES R.P., SARAIVA J.A., BOUSSETTA N., ET AL., EMERGING OPPORTUNITIES FOR THE EFFECTIVE VALORIZATION OF WASTES AND BY-PRODUCTS GENERATED DURING OLIVE OIL PRODUCTION PROCESS: NON-CONVENTIONAL METHODS FOR THE RECOVERY OF HIGH-ADDED VALUE COMPOUNDS, TRENDS IN FOOD SCIENCE & TECHNOLOGY, 45, PP. 296-310, (2015); SANCHEZ J., ILLNAIT J., MAS R., MENDOZA S., FERNANDEZ L., MESA M., LONG-TERM EFFECT OF POLICOSANOL ON THE FUNCTIONAL RECOVERY OF NON-CARDIOEMBOLIC ISCHEMIC STROKE PATIENTS: A ONE YEAR STUDY, REVISTA DE NEUROLOGIA, 64, PP. 153-161, (2017); SIN E.H.K., MARRIOTT R., HUNT A.J., CLARK J.H., IDENTIFICATION, QUANTIFICATION AND CHRASTIL MODELLING OF WHEAT STRAW WAX EXTRACTION USING SUPERCRITICAL CARBON DIOXIDE, COMPTES RENDUS CHIMIE, 17, PP. 293-300, (2014); SINGH D.K., LI L., PORTER T.D., POLICOSANOL INHIBITS CHOLESTEROL SYNTHESIS IN HEPATOMA CELLS BY ACTIVATION OF AMP-KINASE, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 318, PP. 1020-1026, (2006); SOLA R., VALLS R.M., PUZO J., CALABUIG J.R., BREA A., PEDRET A., ET AL., EFFECTS OF POLY-BIOACTIVE COMPOUNDS ON LIPID PROFILE AND BODY WEIGHT IN A MODERATELY HYPERCHOLESTEROLEMIC POPULATION WITH LOW CARDIOVASCULAR DISEASE RISK: A MULTICENTER RANDOMIZED TRIAL, PLOS ONE, 9, (2014); SONG N., GUO H., CHEN G., YANG G., EXTRACTION OF HIGHER ALIPHATIC ALKANOLS FROM SUGARCANE WAX USING TRANSESTERIFICATION, FOOD RESEARCH AND DEVELOPMENT, 29, PP. 28-30, (2008); TANG M., WU S.Z., GONG X., EFFECTS OF POLICOSANOL COMBINED WITH SIMVASTATIN ON SERUM LIPIDS AND SEX HORMONES IN MALE PATIENTS WITH HYPERLIPIDEMIA, CHINESE JOURNAL OF CARDIOVASCULAR, 41, PP. 488-492, (2013); TAYLOR J.C., RAPPORT L., LOCKWOOD G.B., OCTACOSANOL IN HUMAN HEALTH, NUTRITION, 19, PP. 192-195, (2003); TCHAKAM P.D., LUNGA P.K., KOWA T.K., LONFOUO A.H., WABO H.K., ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF THE EXTRACTS AND COMPOUNDS FROM THE LEAVES OF PSOROSPERMUM AURANTIACUM ENGL. AND HYPERICUM LANCEOLATUM LAM, BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 12, PP. 136-143, (2012); TENG H.K., TENG K.K., LEE R., WRIGHT S., TEVAR S., ALMEIDA R.D., ET AL., PROBDNF INDUCES NEURONAL APOPTOSIS VIA ACTIVATION OF A RECEPTOR COMPLEX OF P75NTR AND SORTILIN, JOURNAL OF NEUROSCIENCE, 25, PP. 5455-5463, (2005); THIPPESWAMY G., SHEELA M.L., SALIMATH B.P., OCTACOSANOL ISOLATED FROM TINOSPORA CORDIFOLIA DOWNREGULATES VEGF GENE EXPRESSION BY INHIBITING NUCLEAR TRANSLOCATION OF NF-KAPPAB AND ITS DNA BINDING ACTIVITY, EUROPEAN JOURNAL OF PHARMACOLOGY, 588, PP. 141-150, (2008); TORRES O., AGRAMONTE A.J., ILLNAIT J., MAS FERREIRO R., FERNANDEZ L., FERNANDEZ J.C., TREATMENT OF HYPERCHOLESTEROLEMIA IN NIDDM WITH POLICOSANOL, DIABETES CARE, 18, PP. 393-397, (1995); TRIMARCO V., IZZO R., STABILE E., ROZZA F., SANTORO M.M., MANZI M.V., EFFECTS OF A NEW COMBINATION OF NUTRACEUTICALS WITH MORUS ALBA ON LIPID PROFILE, INSULIN SENSITIVITY AND ENDOTELIAL FUNCTION IN DYSLIPIDEMIC SUBJECTS. A CROSS-OVER, RANDOMIZED, DOUBLE-BLIND TRIAL, HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION, 22, PP. 149-154, (2015); VARADY K.A., WANG Y., JONES P.J., ROLE OF POLICOSANOLS IN THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE, NUTRITION REVIEWS, 61, PP. 376-383, (2003); WANG M.F., LIAN H.Z., MAO L., ZHOU J.P., GONG H.J., QIAN B.Y., ET AL., COMPARISON OF VARIOUS EXTRACTION METHODS FOR POLICOSANOL FROM RICE BRAN WAX AND ESTABLISHMENT OF CHROMATOGRAPHIC FINGERPRINT OF POLICOSANOL, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 55, PP. 5552-5558, (2007); WANG T., LIU Y.Y., WANG X., YANG N., ZHU H.B., ZUO P.P., PROTECTIVE EFFECTS OF OCTACOSANOL ON 6-HYDROXYDOPAMINE-INDUCED PARKINSONISM IN RATS VIA REGULATION OF PRONGF AND NGF SIGNALING, ACTA PHARMACOLOGICA SINICA, 31, PP. 765-774, (2010); WANG T., LIU Y., YANG N., JI C., CHAN P., ZUO P., ANTI-PARKINSONIAN EFFECTS OF OCTACOSANOL IN 1-METHYL-4-PHENYL-1,2,3,6 TETRAHYDROPYRIDINE-TREATED MICE, NEURAL REGENERATION RESEARCH, 14, PP. 1080-1087, (2012); WANG L.J., WELLER C.L., RECENT ADVANCES IN EXTRACTION OF NUTRACEUTICALS FROM PLANTS, TRENDS IN FOOD SCIENCE & TECHNOLOGY, 17, PP. 300-312, (2006); WEERAWATANAKORN M., ASIKIN Y., TAKAHASHI M., TAMAKI H., WADA K., HO C.T., ET AL., PHYSICO-CHEMICAL PROPERTIES, WAX COMPOSITION, AROMA PROFILES, AND ANTIOXIDANT ACTIVITY OF GRANULATED NON-CENTRIFUGAL SUGARS FROM SUGARCANE CULTIVARS OF THAILAND, JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 55, PP. 4684-4692, (2016); WONG W.T., ISMAIL M., TOHIT E.R., ABDULLAH R., ZHANG Y.D., ATTENUATION OF THROMBOSIS BY CRUDE RICE (ORYZA SATIVA) BRAN POLICOSANOL EXTRACT: EX VIVO PLATELET AGGREGATION AND SERUM LEVELS OF ARACHIDONIC ACID METABOLITES, EVIDENCE BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, (2016); YANG H., CHANG Y., WU F., STUDY ON SUPERCRITICAL EXTRACTION OF 1-OCTACOSANOL FROM SUGAR CANE SKIN, CHEMISTRY AND INDUSTRY OF FOREST PRODUCTS, 33, PP. 168-170, (2008)","F. LUO; COLLEGE OF FOOD SCIENCE AND ENGINEERING, CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY, CHANGSHA, NO. 498, SHAOSHAN ROAD, 410004, CHINA; EMAIL: LUOFEIJUN888@CSUFT.EDU.CN","ELSEVIER LTD","ENGLISH","J. FUNCT. FOODS","REVIEW","ISI","2-S2.0-85064467936","J FUNCT FOODS","CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY;CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY;CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY","NOTREPORTED;CENTRAL SOUTH UNIVERSITY OF FORESTRY AND TECHNOLOGY;NOTREPORTED",NA,"SHEN J, 2019, J FUNCT FOODS","SHEN J, 2019, J FUNCT FOODS"
"WONGWAIWECH D;KAMCHONEMENUKOOL S;HO C;LI S;MAJAI N;RUNGRAT T;SUJIPULI K;PAN M;WEERAWATANAKORN M","WONGWAIWECH, DONPORN (57202775373); KAMCHONEMENUKOOL, SUDTHIDA (57219992228); HO, CHI-TANG (56510763200); LI, SHIMING (55741057400); MAJAI, NUTTHAPORN (57881135000); RUNGRAT, TEPSUDA (56067998300); SUJIPULI, KAWEE (57194178928); PAN, MIN-HSIUNG (7202544934); WEERAWATANAKORN, MONTHANA (55976489600)","BIOACTIVES FROM CRUDE RICE BRAN OILS EXTRACTED USING GREEN TECHNOLOGY",2023,"MOLECULES","28","",6,"10.3390/molecules28062457","DEPARTMENT OF AGRO-INDUSTRY, RAJAMANGALA UNIVERSITY OF TECHNOLOGY LANNA TAK, 41/1 MOO 7, MAI NGAM, MUEANG, TAK, 63000, THAILAND;DEPARTMENT OF AGRO-INDUSTRY, NARESUAN UNIVERSITY, 99 MOO 9, THA PHO, MUEANG, PHITSANULOK, 65000, THAILAND;DEPARTMENT OF FOOD SCIENCE, RUTGERS UNIVERSITY, 65 DUDLEY ROAD, NEW BRUNSWICK, 08901, NJ, UNITED STATES;DEPARTMENT OF FOOD SCIENCE, COLLEGE OF LIFE SCIENCES, HUANGGANG NORMAL UNIVERSITY, HUANGGANG, 438000, CHINA;DEPARTMENT OF AGRO-INDUSTRY, NARESUAN UNIVERSITY, 99 MOO 9, THA PHO, MUEANG, PHITSANULOK, 65000, THAILAND;DEPARTMENT OF AGRICULTURAL SCIENCE, FACULTY OF AGRICULTURE, NATURAL RESOURCES AND ENVIRONMENT, NARESUAN UNIVERSITY, 99 MOO 9, THA PHO, MUEANG, PHITSANULOK, 65000, THAILAND;DEPARTMENT OF AGRICULTURAL SCIENCE, FACULTY OF AGRICULTURE, NATURAL RESOURCES AND ENVIRONMENT, NARESUAN UNIVERSITY, 99 MOO 9, THA PHO, MUEANG, PHITSANULOK, 65000, THAILAND;INSTITUTE OF FOOD SCIENCE AND TECHNOLOGY, NATIONAL TAIWAN UNIVERSITY, NO.1, SECTION 4, ROOSEVELT ROAD, TAIPEI, 10617, TAIWAN;DEPARTMENT OF AGRO-INDUSTRY, NARESUAN UNIVERSITY, 99 MOO 9, THA PHO, MUEANG, PHITSANULOK, 65000, THAILAND","CRUDE RICE BRAN OILS FROM DIFFERENT RICE CULTIVARS AND EXTRACTION METHODS BEAR DIFFERENT CONTENTS OF NUTRACEUTICALS. THE HEALTH BENEFITS OF LOWERING CHOLESTEROL ACTIVITY OF RICE BRAN OIL BEING CONFIRMED BY MANY REPORTS ARE PARTLY ATTRIBUTED TO NON-NUTRIENT NUTRACEUTICALS, ESPECIALLY Γ-ORYZANOL, PHYTOSTEROLS, AND POLICOSANOLS. AS THE WORLD HAS BEEN FACING THE GLOBAL WARMING CRISIS, GREEN EXTRACTION TECHNOLOGY IS GAINING ATTENTION FROM MANY SECTORS. THE CURRENT STUDY AIMS TO COMPARE THE NUTRACEUTICAL COMPOSITION WITH RESPECT TO Γ-ORYZANOL, PHYTOSTEROL, AND POLICOSANOL CONTENT AS WELL AS THE ANTIOXIDANT PROPERTIES OF CRUDE RICE BRAN OILS EXTRACTED FROM WHITE AND RED RICE BRAN USING THREE GREEN TECHNOLOGIES, COMPARING WITH CONVENTIONAL HEXANE EXTRACTION. THE DATA SHOW THAT THE TRADITIONAL SOLVENT EXTRACTION GAVE THE HIGHEST OIL YIELD PERCENTAGE (26%), BUT IT WAS NOT SIGNIFICANTLY DIFFERENT FROM SUBCRITICAL LIQUEFIED DIMETHYL ETHER EXTRACTION (24.6%). SUBCRITICAL LIQUEFIED DIMETHYL ETHER EXTRACTION GAVE HIGHER OIL YIELD THAN SUPERCRITICAL CO2 EXTRACTION (15.5–16.2%). THE CRUDE RICE BRAN OIL EXTRACTED USING SUBCRITICAL LIQUEFIED DIMETHYL ETHER EXTRACTION PRODUCED THE HIGHEST TOTAL PHENOLIC CONTENTS AND ANTIOXIDANT ACTIVITIES. THE HIGHEST Γ-ORYZANOL CONTENT OF THE CRUDE RICE BRAN OIL WAS FOUND IN OIL EXTRACTED BY CONVENTIONAL COLD PRESS (1370.43 MG/100 G). THE Γ-ORYZANOL CONTENT OF THE OIL OBTAINED VIA SUBCRITICAL LIQUEFIED DIMETHYL ETHER EXTRACTION WAS HIGH (1213.64 MG/100 G) COMPARED WITH SUPERCRITICAL CO2 EXTRACTION. THE RED RICE BRAN YIELDED THE CRUDE RICE BRAN OIL WITH THE HIGHEST TOTAL PHYTOSTEROL CONTENT COMPARED WITH THE WHITE BRAN, AND THE OIL FROM RED RICE BRAN EXTRACTED WITH SUBCRITICAL LIQUEFIED DIMETHYL ETHER GENERATED THE HIGHEST TOTAL PHYTOSTEROL CONTENT (1784.17 MG/100 G). THE HIGHEST POLICOSANOL CONTENT (274.40 MG/100 G) WAS ALSO FOUND IN OIL OBTAINED VIA SUBCRITICAL LIQUEFIED DIMETHYL ETHER EXTRACTION. © 2023 BY THE AUTHORS.","ORYZANOL; PHYTOSTEROL; POLICOSANOL; SUBCRITICAL EXTRACTION; SUPERCRITICAL EXTRACTION","ANTIOXIDANTS; CARBON DIOXIDE; ORYZA; PHENYLPROPIONATES; PHYTOSTEROLS; RICE BRAN OIL; ANTIOXIDANT; CARBON DIOXIDE; DIMETHYL ETHER; GAMMA-ORYZANOL; PHENYLPROPIONIC ACID DERIVATIVE; PHYTOSTEROL; POLICOSANOL; RICE BRAN OIL; ORYZA","THAILAND SCIENCE RESEARCH AND INNOVATION, TSRI","THIS RESEARCH WAS FUNDED BY THAILAND SCIENCE RESEARCH AND INNOVATION (TRSI) IN FISCAL YEAR 2022 (GRANT NUMBER FRB650022/0179) AND NARESUAN UNIVERSITY (GRANT NUMBER R2565B007).","LIU R., XU Y., CHANG M., TANG L., LU M., LIU R., JIN Q., WANG X., ANTIOXIDANT INTERACTION OF Α-TOCOPHEROL, Γ-ORYZANOL AND PHYTOSTEROL IN RICE BRAN OIL, FOOD CHEM, 343, (2021); JUNG D.M., LEE M.J., YOON S.H., JUNG M.Y., A GAS CHROMATOGRAPHY-TANDEM QUADRUPOLE MASS SPECTROMETRIC ANALYSIS OF POLICOSANOLS IN COMMERCIAL VEGETABLE OILS, J. FOOD SCI, 76, PP. 891-899, (2011); CRAVOTTO G., BINELLO A., MERIZZI G., AVOGADRO M., IMPROVING SOLVENT-FREE EXTRACTION OF POLICOSANOL FROM RICE BRAN BY HIGH-INTENSITY ULTRASOUND TREATMENT, EUR. J. LIPID SCI. TECHNOL, 106, PP. 147-151, (2004); KRISHNA A.G.G., KHATOON S., SHIELA P.M., SARMANDAL C.V., INDIRA T.N., MISHRA A., EFFECT OF REFINING OF CRUDE RICE BRAN OIL ON THE RETENTION OF ORYZANOL IN THE REFINED OIL, J. AM. OIL CHEM. SOC, 78, PP. 127-131, (2001); ORTHOEFER F.T., RICE BRAN OIL, BAILEY’S INDUSTRIAL OIL AND FAT PRODUCTS, 2, PP. 465-489, (2005); HUANG Y.P., LAI H.M., BIOACTIVE COMPOUNDS AND ANTIOXIDATIVE ACTIVITY OF COLORED RICE BRAN, J. FOOD DRUG ANAL, 24, PP. 564-574, (2016); KIM H.W., LEE A.Y., YEO S.K., CHUNG H., LEE J.H., HOANG M.H., JIA Y., HAN S.I., OH S.K., LEE S.J., ET AL., METABOLIC PROFILING AND BIOLOGICAL MECHANISMS OF BODY FAT REDUCTION IN MICE FED THE ETHANOLIC EXTRACT OF BLACK-COLORED RICE, FOOD RES. INT, 53, PP. 373-390, (2013); LING W.H., CHENG Q.X., MA J., WANG T., RED AND BLACK RICE DECREASE ATHEROSCLEROTIC PLAQUE FORMATION AND INCREASE ANTIOXIDANT STATUS IN RABBITS, J. NUTR, 131, PP. 1421-1426, (2001); RATTANACHITTHAWAT S., SUWANNALERT P., RIENGROJPITAK S., CHAIYASUT C., PANTUWATANA S., PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITIES IN RED UNPOLISHED THAI RICE PREVENTS OXIDATIVE STRESS IN RATS, J. MED. PLANTS RES, 4, PP. 796-801, (2010); WANG Q., HAN P., ZHANG M., XIA M., ZHU H., MA J., HOU M., TANG Z., LING W., SUPPLEMENTATION OF BLACK RICE PIGMENT FRACTION IMPROVES ANTIOXIDANT AND ANTI-INFLAMMATORY STATUS IN PATIENTS WITH CORONARY HEART DISEASE, ASIA PAC. J. CLIN. NUTR, 16, PP. 295-301, (2007); KERCKHOFFS D.A.J.M., BROUNS F., HORNSTRA G., MENSINK R.P., EFFECTS ON THE HUMAN SERUM LIPOPROTEIN PROFILE OF Β-GLUCAN, SOY PROTEIN AND ISOFLAVONES, PLANT STEROLS AND STANOLS, GARLIC AND TOCOTRIENOLS, J. NUTR, 132, PP. 2494-2505, (2002); MOST M.M., TULLEY R., MORALES S., LEFEVRE M., RICE BRAN OIL, NOT FIBER, LOWERS CHOLESTEROL IN HUMANS, AM. J. CLIN. NUTR, 81, PP. 64-68, (2005); HONGU N., KITTS D.D., ZAWISTOWSKI J., DOSSETT C.M., KOPEC A., POPE B.T., BUCHOWSKI M.S., PIGMENTED RICE BRAN AND PLANT STEROL COMBINATION REDUCES SERUM LIPIDS IN OVERWEIGHT AND OBESE ADULTS, J. AM. COLL. NUTR, 33, PP. 231-238, (2014); VAN HOED V., DEPAEMELAERE G., AYALA J.V.V., SANTIWATTANA P., VERHE R., GREYT W., DE INFLUENCE OF CHEMICAL REFINING ON THE MAJOR AND MINOR COMPONENTS OF RICE BRAN OIL, J. AM. OIL CHEM. SOC, 83, PP. 315-321, (2006); IQBAL J., MINHAJUDDIN M., BEG Z., SUPPRESSION OF 7,12-DIMETHYLBENZALPHAANTHRACENE-INDUCED CARCINOGENESIS AND HYPERCHOLESTEROLAEMIA IN RATS BY TOCOTRIENOL-RICH FRACTION ISOLATED FROM RICE BRAN OIL, EUR. J. CANCER PREV, 12, PP. 447-453, (2003); RONG N., AUSMAN L.M., NICOLOSI R.J., ORYZANOL DECREASES CHOLESTEROL ABSORPTION AND AORTIC FATTY STREAKS IN HAMSTERS, LIPIDS, 32, PP. 303-309, (1997); WESTER I., CHOLESTEROL-LOWERING EFFECT OF PLANT STEROLS, EUR. J. LIPID SCI. TECHNOL, 102, PP. 37-44, (2000); PINTO T.I., COELHO J.A., PIRES B.I., NENG N.R., NOGUEIRA J.M., BORDADO J.C., SARDINHA J.P., SUPERCRITICAL CARBON DIOXIDE EXTRACTION, ANTIOXIDANT ACTIVITY, AND FATTY ACID COMPOSITION OF BRAN OIL FROM RICE VARIETIES CULTIVATED IN PORTUGAL, SEPARATIONS, 8, (2021); CHAROENCHAI L., SUKSAEREE J., MONTON C., CHUSUT T., KRAISINTU K., METHOD VALIDATION AND DETERMINATION OF FATTY ACID COMPONENTS IN COLD PRESSED RBO USING GAS CHROMATOGRAPHY, RANGSIT J. ARTS SCI, 3, (2013); CAKALOGLU B., OZYURT V.H., OTLES S., COLD PRESS IN OIL EXTRACTION. A REVIEW, UKR. FOOD J, 7, PP. 640-654, (2018); RESHAD A.S., TIWARI P., GOUD V.V., EXTRACTION OF OIL FROM RUBBER SEEDS FOR BIODIESEL APPLICATION: OPTIMIZATION OF PARAMETERS, FUEL, 150, PP. 636-644, (2015); BOONNOUN P., SHOTIPRUK A., KANDA H., GOTO M., OPTIMIZATION OF RUBBER SEED OIL EXTRACTION USING LIQUEFIED DIMETHYL ETHER, CHEM. ENG. COMMUN, 206, PP. 746-753, (2018); LI J., SUN D., QIAN L., LIU Y., SUBCRITICAL BUTANE EXTRACTION OF WHEAT GERM OIL AND ITS DEACIDIFICATION BY MOLECULAR DISTILLATION, MOLECULES, 21, (2016); MUNIR M.T., KHEIRKHAH H., BAROUTIAN S., QUEK S.Y., YOUNG B.R., SUBCRITICAL WATER EXTRACTION OF BIOACTIVE COMPOUNDS FROM WASTE ONION SKIN, J. CLEAN. PROD, 183, PP. 487-494, (2018); CHEIGH C.I., YOO S.Y., KO M.J., CHANG P.S., CHUNG M.S., EXTRACTION CHARACTERISTICS OF SUBCRITICAL WATER DEPENDING ON THE NUMBER OF HYDROXYL GROUP IN FLAVONOLS, FOOD CHEM, 168, PP. 21-26, (2015); SUN D., CAO C., LI B., CHEN H., LI J., CAO P., LIU Y., ANTARCTIC KRILL LIPID EXTRACTED BY SUBCRITICAL N-BUTANE AND COMPARISON WITH SUPERCRITICAL CO<SUB>2</SUB> AND CONVENTIONAL SOLVENT EXTRACTION, LWT, 94, PP. 1-7, (2018); SANTOS K.A., BARICCATTI R.A., CARDOZO-FILHO L., SCHNEIDER R., PALU F., DA SILVA C., DA SILVA E.A., EXTRACTION OF CRAMBE SEED OIL USING SUBCRITICAL PROPANE: KINETICS, CHARACTERIZATION AND MODELING, J. SUPERCRIT. FLUIDS, 104, PP. 54-61, (2015); XU B., HAN J., ZHOU S., WU Q., DING F., QUALITY CHARACTERISTICS OF WHEAT GERM OIL OBTAINED BY INNOVATIVE SUBCRITICAL BUTANE EXPERIMENTAL EQUIPMENT, J. FOOD PROCESS ENG, 39, PP. 79-87, (2016); KO M.J., CHEIGH C.I., CHUNG M.S., RELATIONSHIP ANALYSIS BETWEEN FLAVONOIDS STRUCTURE AND SUBCRITICAL WATER EXTRACTION (SWE), FOOD CHEM, 143, PP. 147-155, (2014); HERRERO M., CASTRO-PUYANA M., MENDIOLA J.A., IBANEZ E., COMPRESSED FLUIDS FOR THE EXTRACTION OF BIOACTIVE COMPOUNDS, TRAC—TRENDS ANAL. CHEM, 43, PP. 67-83, (2013); SAPKALE G.N., PATIL S.M., SURWASE U.S., BHATBHAGE P.K., SUPERCRITICAL FLUID EXTRACTION—A REVIEW, INT. J. CHEM. SCI, 8, PP. 729-743, (2010); FANG Y., GU S., LIU S., ZHANG J., DING Y., LIU J., EXTRACTION OF OIL FROM HIGH-MOISTURE TUNA LIVER BY SUBCRITICAL DIMETHYL ETHER: FEASIBILITY AND OPTIMIZATION BY THE RESPONSE SURFACE METHOD, RSC ADV, 8, PP. 2723-2732, (2018); SUBRATTI A., LALGEE L.J., JALSA N.K., LIQUIFIED DIMETHYL ETHER (DME): A GREEN SOLVENT FOR THE EXTRACTION OF HEMP (CANNABIS SATIVA L.) SEED OIL, SUSTAIN. CHEM. PHARM, 12, (2019); KANDA H., KAMO Y., MACHMUDAH S., WAHYUDIONO S., GOTO M., EXTRACTION OF FUCOXANTHIN FROM RAW MACROALGAE EXCLUDING DRYING AND CELL WALL DISRUPTION BY LIQUEFIED DIMETHYL ETHER, MAR. DRUGS, 12, PP. 2383-2396, (2014); KANDA H., LI P., MAKINO H., PRODUCTION OF DECAFFEINATED GREEN TEA LEAVES USING LIQUEFIED DIMETHYL ETHER, FOOD BIOPROD. PROCESS, 91, PP. 376-380, (2013); GOTO M., KANDA H., WAHYUDIONO H., MACHMUDAH S., EXTRACTION OF CAROTENOIDS AND LIPIDS FROM ALGAE BY SUPERCRITICAL CO<SUB>2</SUB> AND SUBCRITICAL DIMETHYL ETHER, J. SUPERCRIT. FLUIDS, 96, PP. 245-251, (2015); KANDA H., LI P., SIMPLE EXTRACTION METHOD OF GREEN CRUDE FROM NATURAL BLUE-GREEN MICROALGAE BY DIMETHYL ETHER, FUEL, 90, PP. 1264-1266, (2011); SCIENTIFIC OPINION ON THE SAFETY OF USE OF DIMETHYL ETHER AS AN EXTRACTION SOLVENT UNDER THE INTENDED CONDITIONS OF USE AND THE PROPOSED MAXIMUM RESIDUAL LIMITS, EUR. FOOD SAF. AUTH. J, 13, (2015); APPLICATION A1056 DIMETHYL ETHER AS A PROCESSING AID FOR DAIRY INGREDIENTS & PRODUCTS ASSESSMENT REPORT, (2011); VAKILI R., POURAZADI E., SETOODEH P., ESLAMLOUEYAN R., RAHIMPOUR M.R., DIRECT DIMETHYL ETHER (DME) SYNTHESIS THROUGH A THERMALLY COUPLED HEAT EXCHANGER REACTOR, APPL. ENERGY, 88, PP. 1211-1223, (2011); PEINADO C., LIUZZI D., LADERA-GALLARDO R.M., RETUERTO M., OJEDA M., PENA M.A., ROJAS S., EFFECTS OF SUPPORT AND REACTION PRESSURE FOR THE SYNTHESIS OF DIMETHYL ETHER OVER HETEROPOLYACID CATALYSTS, SCI. REP, 10, (2020); SUN J., YANG G., YONEYAMA Y., TSUBAKI N., CATALYSIS CHEMISTRY OF DIMETHYL ETHER SYNTHESIS, ACS CATAL, 4, PP. 3346-3356, (2014); BANIVAHEB S., PITTER S., DELGADO K.H., RUBIN M., SAUER J., DITTMEYER R., RECENT PROGRESS IN DIRECT DME SYNTHESIS AND POTENTIAL OF BIFUNCTIONAL CATALYSTS, CHEM. ING. TECH, 94, PP. 240-255, (2022); DELRUE F., SETIER P.A., SAHUT C., COURNAC L., ROUBAUD A., PELTIER G., FROMENT A.K., AN ECONOMIC, SUSTAINABILITY, AND ENERGETIC MODEL OF BIODIESEL PRODUCTION FROM MICROALGAE, BIORESOUR. TECHNOL, 111, PP. 191-200, (2012); GUO T., WAN C., HUANG F., EXTRACTION OF RAPESEED CAKE OIL USING SUBCRITICAL R134A/BUTANE: PROCESS OPTIMIZATION AND QUALITY EVALUATION, FOOD SCI. NUTR, 7, PP. 3570-3580, (2019); QI Z., XIAO J., YE L., CHUYUN W., CHANG Z., SHUGANG L., FENGHONG H., THE EFFECT OF THE SUBCRITICAL FLUID EXTRACTION ON THE QUALITY OF ALMOND OILS: COMPARED TO CONVENTIONAL MECHANICAL PRESSING METHOD, FOOD SCI. NUTR, 7, PP. 2231-2241, (2019); TEIXEIRA G.L., GHAZANI S.M., CORAZZA M.L., MARANGONI A.G., RIBANI R.H., ASSESSMENT OF SUBCRITICAL PROPANE, SUPERCRITICAL CO<SUB>2</SUB> AND SOXHLET EXTRACTION OF OIL FROM SAPUCAIA (LECYTHIS PISONIS) NUTS, J. SUPERCRIT. FLUIDS, 133, PP. 122-132, (2018); GAO P., LIU R., JIN Q., WANG X., EFFECTS OF PROCESSING METHODS ON THE CHEMICAL COMPOSITION AND ANTIOXIDANT CAPACITY OF WALNUT (JUGLANS REGIA L.) OIL, LWT, 135, (2021); STEVANATO N., IWASSA I.J., CARDOZO-FILHO L., DA SILVA C., QUALITY PARAMETERS OF RADISH SEED OIL OBTAINED USING COMPRESSED PROPANE AS SOLVENT, J. SUPERCRIT. FLUIDS, 159, (2020); OLIVEIRA D.A., ANGONESE M., GOMES C., FERREIRA S.R.S., VALORIZATION OF PASSION FRUIT (PASSIFLORA EDULIS SP.) BY-PRODUCTS: SUSTAINABLE RECOVERY AND BIOLOGICAL ACTIVITIES, J. SUPERCRIT. FLUIDS, 111, PP. 55-62, (2016); ERSAN S., GUCLU USTUNDAG O., CARLE R., SCHWEIGGERT R.M., SUBCRITICAL WATER EXTRACTION OF PHENOLIC AND ANTIOXIDANT CONSTITUENTS FROM PISTACHIO (PISTACIA VERA L.) HULLS, FOOD CHEM, 253, PP. 46-54, (2018); ZANQUI A.B., DA SILVA C.M., RESSUTTE J.B., ROTTA E.M., CARDOZO-FILHO L., MATSUSHITA M., CASHEW NUT OIL EXTRACTED WITH COMPRESSED PROPANE UNDER DIFFERENT EXPERIMENTAL CONDITIONS: EVALUATION OF LIPID COMPOSITION, J. FOOD PROCESS. PRESERV, 44, (2020); WANG S., ZHANG Z.S., ZHANG T.F., WANG X., DE EXTRACTION AND CHARACTERIZATION OF FLAXSEED OIL OBTAINED WITH SUBCRITICAL N-BUTANE, J. OLEO SCI, 69, PP. 1011-1020, (2020); SOARES J.F., PRA V.D., BARRALES F.M., DOS SANTOS P., KUHN R.C., REZENDE C.A., MARTINEZ J., MAZUTTI M.A., EXTRACTION OF RICE BRAN OIL USING SUPERCRITICAL CO<SUB>2</SUB> COMBINED WITH ULTRASOUND, BRAZILIAN J. CHEM. ENG, 35, PP. 785-794, (2018); KUK M.S., DOWD M.K., SUPERCRITICAL CO<SUB>2</SUB> EXTRACTION OF RICE BRAN, J. AM. OIL CHEM. SOC, 75, PP. 623-628, (1998); SOARES J.F., DAL PRA V., DE SOUZA M., LUNELLI F.C., ABAIDE E., DA SILVA J.R.F., KUHN R.C., MARTINEZ J., MAZUTTI M.A., EXTRACTION OF RICE BRAN OIL USING SUPERCRITICAL CO<SUB>2</SUB> AND COMPRESSED LIQUEFIED PETROLEUM GAS, J. FOOD ENG, 170, PP. 58-63, (2016); LIU H.-M., WANG F.-Y., LI H.-Y., WANG X.-D., QIN G.-Y., SUBCRITICAL BUTANE AND PROPANE EXTRACTION OF OIL FROM RICE BRAN, BIORESOURCES, 10, PP. 4652-4662, (2015); CHEN C.-R., WANG C.-H., WANG L.-Y., HONG Z.-H., CHEN S.-H., HO W.-J., CHANG C.-M.J., SUPERCRITICAL CARBON DIOXIDE EXTRACTION AND DEACIDIFICATION OF RICE BRAN OIL, J. SUPERCRIT. FLUIDS, 45, PP. 322-331, (2008); CHIA S.L., BOO H.C., MUHAMAD K., SULAIMAN R., UMANAN F., CHONG G.H., EFFECT OF SUBCRITICAL CARBON DIOXIDE EXTRACTION AND BRAN STABILIZATION METHODS ON RICE BRAN OIL, J. AM. OIL CHEM. SOC, 92, PP. 393-402, (2015); SARMENTO C.M.P., FERREIRA S.R.S., HENSE H., SUPERCRITICAL FLUID EXTRACTION (SFE) OF RICE BRAN OIL TO OBTAIN FRACTIONS ENRICHED WITH TOCOPHEROLS AND TOCOTRIENOLS, BRAZILIAN J. CHEM. ENG, 23, PP. 243-249, (2006); PENGKUMSRI N., CHAIYASUT C., SAENJUM C., SIRILUN S., PEERAJAN S., SUWANNALERT P., SIRISATTHA S., SIVAMARUTHI B.S., PHYSICOCHEMICAL AND ANTIOXIDATIVE PROPERTIES OF BLACK, BROWN AND RED RICE VARIETIES OF NORTHERN THAILAND, FOOD SCI. TECHNOL, 35, PP. 331-338, (2015); MINGYAI S., KETTAWAN A., SRIKAEO K., SINGANUSONG R., PHYSICOCHEMICAL AND ANTIOXIDANT PROPERTIES OF RICE BRAN OILS PRODUCED FROM COLORED RICE USING DIFFERENT EXTRACTION METHODS, J. OLEO SCI, 572, PP. 565-572, (2017); DUNFORD N.T., KING J.W., SUPERCRITICAL CARBON DIOXIDE FRACTIONATION OF CRUDE RICE BRAN OIL USING A PACKED COLUMN WITH CHARACTERIZATION OF THE RESULTANT FRACTIONS, PROCEEDINGS OF THE 5TH INTERNATIONAL SYMPOSIUM ON SUPERCRITICAL FLUIDS; BONDIOLI P., MARIANI C., LANZANI A., FEDELI E., MOSSA A., MULLER A., LAMPANTE OLIVE OIL REFINING WITH SUPERCRITICAL CARBON DIOXIDE, J. AM. OIL CHEM. SOC, 69, PP. 477-480, (1992); BRUNETTI L., DAGHETTA A., FEDELL E., KIKIC I., ZANDERIGHI L., DEACIDIFICATION OF OLIVE OILS BY SUPERCRITICAL CARBON DIOXIDE, J. AM. OIL CHEM. SOC, 66, PP. 209-217, (1989); ARORA R., TOOR A.P., WANCHOO R.K., ESTERIFICATION OF HIGH FREE FATTY ACID RICE BRAN OIL: PARAMETRIC AND KINETIC STUDY, CHEM. BIOCHEM. ENG. Q, 29, PP. 617-623, (2015); PANDEY A., HANDBOOK OF PLANT-BASED BIOFUELS, (2008); AMIN S.K., ABDALLAH H.A.M., ENHANCEMENT OF FREE FATTY ACID IN RICE BRAN OIL FOR ACID CATALYSIS BIODIESEL PRODUCTION, AUST. J. BASIC APPL. SCI, 6, PP. 795-806, (2012); OLUREMI O.I., SOLOMON A.O., SAHEED A.A., FATTY ACIDS, METAL COMPOSITION AND PHYSICO-CHEMICAL PARAMETERS OF IGBEMO EKITI RICE BRAN OIL, ENVIRON. CHEM, 5, PP. 39-46, (2013); CODEX STANDARD FOR NAMED VEGETABLE OILS CXS 210-1999; SAWADIKIAT P., HONGSPRABHAS P., PHYTOSTEROLS AND Γ-ORYZANOL IN RICE BRAN OILS AND DISTILLATES FROM PHYSICAL REFINING PROCESS, INT. J. FOOD SCI. TECHNOL, 49, PP. 2030-2036, (2014); MALEKIAN F., RAO R.M., PRINYAWIWATKUL W., MARSHALL W.E., WINDHAUSER M., AHMEDNA M., LIPASE AND LIPOXYGENASE ACTIVITY, FUNCTIONALITY, AND NUTRIENT LOSSES IN RICE BRAN DURING STORAGE, PP. 1-70, (2000); THANONKAEW A., WONGYAI S., MCCLEMENTS D.J., DECKER E.A., EFFECT OF STABILIZATION OF RICE BRAN BY DOMESTIC HEATING ON MECHANICAL EXTRACTION YIELD, QUALITY, AND ANTIOXIDANT PROPERTIES OF COLD-PRESSED RICE BRAN OIL (ORYZA SALTIVA L.), LWT, 48, PP. 231-236, (2012); KILIC B., RICHARDS M.P., LIPID OXIDATION IN POULTRY DÖNER KEBAB: PRO-OXIDATIVE AND ANTI-OXIDATIVE FACTORS, J. FOOD SCI, 68, PP. 686-689, (2003); LEARDKAMOLKARN V., THONGTHEP W., SUTTIARPORN P., KONGKACHUICHAI R., WONGPORNCHAI S., WANAVIJITR A., CHEMOPREVENTIVE PROPERTIES OF THE BRAN EXTRACTED FROM A NEWLY-DEVELOPED THAI RICE: THE RICEBERRY, FOOD CHEM, 125, PP. 978-985, (2011); KONGTHITILERD P., SUANTAWEE T., CHENG H., THILAVECH T., MARNPAE M., ADISAKWATTANA S., ANTHOCYANIN-ENRICHED RICEBERRY RICE EXTRACT INHIBITS CELL PROLIFERATION AND ADIPOGENESIS IN 3T3-L1 PREADIPOCYTES BY DOWNREGULATING ADIPOGENIC TRANSCRIPTION FACTORS AND THEIR TARGETING GENES, NUTRIENTS, 12, (2020); SETTAPRAMOTE N., LAOKULDILOK T., BOONYAWAN D., UTAMA-ANG N., PHYSIOCHEMICAL, ANTIOXIDANT ACTIVITIES AND ANTHOCYANIN OF RICEBERRY RICE FROM DIFFERENT LOCATIONS IN THAILAND, FOOD APPL. BIOSCI. J, 6, PP. 84-94, (2018); DUTHIE G.G., DUTHIE S.J., KYLE J.A.M., PLANT POLYPHENOLS IN CANCER AND HEART DISEASE: IMPLICATIONS AS NUTRITIONAL ANTIOXIDANTS, NUTR. RES. REV, 13, PP. 79-106, (2000); KRGA I., MILENKOVIC D., ANTHOCYANINS: FROM SOURCES AND BIOAVAILABILITY TO CARDIOVASCULAR-HEALTH BENEFITS AND MOLECULAR MECHANISMS OF ACTION, J. AGRIC. FOOD CHEM, 67, PP. 1771-1783, (2019); TIAN L., TAN Y., CHEN G., WANG G., SUN J., OU S., CHEN W., BAI W., METABOLISM OF ANTHOCYANINS AND CONSEQUENT EFFECTS ON THE GUT MICROBIOTA, CRIT. REV. FOOD SCI. NUTR, 59, PP. 982-991, (2019); AKIYA T., COMPONENTS OF UNSAPONIFIABLE MATTER OF RICE BRAN BY TOSHIMI AKIYA FOOD RESEARCH INSTITUTE, MINISTRY OF AGRICULTURE AND FORESTRY, TOKYO IN SEVERAL COUNTRIES, RICE BRAN IS A POTENTIAL SOURCE OF OIL IN CONSIDERABLE QUANTITY, AGRIC. BIOL. CHEM, 26, PP. 180-186, (1962); HVOLBY A., REMOVAL OF NONHYDRATABLE PHOSPHOLIPIDS FROM SOYBEAN OIL, J. AM. OIL CHEM. SOC, 48, PP. 503-509, (1971); LILITCHAN S., ARYUSUK K., HEALTH BENEFITS AND PRODUCTION OF POLICOSANOL FROM RICE BRAN WAX, J. PUBLIC HEALTH, 38, PP. 457-464, (2008); JENNINGS B.H., AKOH C.C., TRANS-FREE PLASTIC SHORTENINGS PREPARED WITH PALM STEARIN AND RICE BRAN OIL STRUCTURED LIPID, J. AM. OIL CHEM. SOC, 87, PP. 411-417, (2010); HUSSAIN N., ISHAK I., AGUS B.A.P., SAMAH N.F.A., EFFECTS OF DIFFERENT STABILIZATION CONDITIONS AND EXTRACTION METHODS (SOXHLET AND ULTRASONIC-ASSISTED) ON QUALITY OF RICE BRAN OIL, EMIR. J. FOOD AGRIC, 33, PP. 220-227, (2021); GOPALA KRISHNA A.G., INFLUENCE OF VISCOSITY ON WAX SETTLING AND REFINING LOSS IN RICE BRAN OIL, J. AM. OIL CHEM. SOC, 70, PP. 895-898, (1993); JUN H.I., SONG G.S., YANG E.I., YOUN Y., KIM Y.S., ANTIOXIDANT ACTIVITIES AND PHENOLIC COMPOUNDS OF PIGMENTED RICE BRAN EXTRACTS, J. FOOD SCI, 77, PP. C759-C764, (2012); LAOKULDILOK T., SHOEMAKER C.F., JONGKAEWWATTANA S., TULYATHAN V., ANTIOXIDANTS AND ANTIOXIDANT ACTIVITY OF SEVERAL PIGMENTED RICE BRANS, J. AGRIC. FOOD CHEM, 59, PP. 193-199, (2011); WISETKOMOLMAT J., ARJIN C., SATSOOK A., SEEL-AUDOM M., RUKSIRIWANICH W., PROM-U-THAI C., SRINGARM K., COMPARATIVE ANALYSIS OF NUTRITIONAL COMPONENTS AND PHYTOCHEMICAL ATTRIBUTES OF SELECTED THAI RICE BRAN, FRONT. NUTR, 9, (2022); PENGKUMSRI N., CHAIYASUT C., SIVAMARUTHI B.S., SAENJUM C., SIRILUN S., PEERAJAN S., SUWANNALERT P., SIRISATTHA S., CHAIYASUT K., KESIKA P., THE INFLUENCE OF EXTRACTION METHODS ON COMPOSITION AND ANTIOXIDANT PROPERTIES OF RICE BRAN OIL, FOOD SCI. TECHNOL, 35, PP. 493-501, (2015); XU Z., GODBER J.S., COMPARISON OF SUPERCRITICAL FLUID AND SOLVENT EXTRACTION METHODS IN EXTRACTING Γ-ORYZANOL FROM RICE BRAN, J. AM. OIL CHEM. SOC, 77, PP. 547-551, (2000); RUEN-NGAM D., THAWAI C., SUKONTHAMAT S., KHUWARANYU K., EFFECT OF SUBCRITICAL SOLVENT EXTRACTION CONDITIONS ON AMOUNT OF Γ-ORYZANOL AND Γ-TOCOPHEROL IN DAWK PA-YOM RICE BRAN OIL, CURR. APPL. SCI. TECHNOL, 21, PP. 151-161, (2021); KATSRI K., NOITUP P., JUNSANGSREE P., SINGANUSONG R., THE OPTIMUM MIXING RATIO BETWEEN HYDROGENATED PALM KERNEL OIL AND COLD- PRESSED RICE BRAN OIL FOR FURTHER UTILIZATION IN LIQUID COFFEE WHITENER, PROCEEDINGS OF THE 13TH ASEAN FOOD CONFERENCE 2013: MEETING FUTURE FOOD DEMANDS: SECURITY & SUSTAINABILITY, PP. 9-11; PATEL M., NAIK S.N., GAMMA-ORYZANOL FROM RICE BRAN OIL—A REVIEW, J. SCI. IND. RES, 63, PP. 569-578, (2004); SOMSEEMEE O., MORAKOT N., SITTIWET C., ANALYSIS OF STEROL CONTENT IN JASMINE RICE (ORYZA SATIVA), PROCEEDINGS OF THE RAJABHAT MAHA SARAKHAM UNIVERSITY RESEARCH CONFERENCE, PP. 1-10; MINGYAI S., SRIKAEO K., KETTAWAN A., SINGANUSONG R., NAKAGAWA K., KIMURA F., ITO J., EFFECTS OF EXTRACTION METHODS ON PHYTOCHEMICALS OF RICE BRAN OILS PRODUCED FROM COLORED RICE, J. OLEO SCI, 67, PP. 135-142, (2018); DERAKHSHAN-HONARPARVAR M., HAMEDI M.M., PIROUZIFARD M.K., RICE BRAN PHYTOSTEROLS OF THREE WIDESPREAD IRANIAN CULTIVARS, J. AGRIC. SCI. TECHNOL, 12, PP. 167-172, (2010); GECGEL U., DAGLIOGLU O., YILMAZ I., ARICI M., GUNER K.G., APAYDIN D., DULGER G.C., ONUR A.Y., ERSOZ B., COTRA Y., ET AL., DETERMINATION OF PHYSICOCHEMICAL PROPERTIES AND OXIDATIVE STABILITY OF RICE BRAN OILS, J. TEKIRDAG AGRIC. FAC, 14, PP. 93-102, (2017); SALEHI E.A., SARDARODIYAN M., BIOACTIVE PHYTOCHEMICALS IN RICE BRAN: PROCESSING AND FUNCTIONAL PROPERTIES, BIOCHEMISTRY, 10, (2016); BALACHANDRAN C., MAYAMOL P.N., THOMAS S., SUKUMAR D., SUNDARESAN A., ARUMUGHAN C., AN ECOFRIENDLY APPROACH TO PROCESS RICE BRAN FOR HIGH QUALITY RICE BRAN OIL USING SUPERCRITICAL CARBON DIOXIDE FOR NUTRACEUTICAL APPLICATIONS, BIORESOUR. TECHNOL, 99, PP. 2905-2912, (2008); KAMCHONEMENUKOOL S., HO C.-T., BOONNOUN P., LI S., PAN M.-H., KLANGPETCH W., WEERAWATANAKORN M., HIGH LEVELS OF POLICOSANOLS AND PHYTOSTEROLS FROM SUGAR MILL WASTE BY SUBCRITICAL LIQUEFIED DIMETHYL ETHER, FOODS, 11, (2022); ZANQUI A.B., DA SILVA C.M., RESSUTTE J.B., DE MORAIS D.R., SANTOS J.M., EBERLIN M.N., CARDOZO-FILHO L., VISENTAINER J.V., GOMES S.T.M., MATSUSHITA M., BRAZIL NUT OIL EXTRACTION USING SUBCRITICAL, J. BRAZ. CHEM. SOC, 31, PP. 603-612, (2020); HAN J.H., WU Q.F., XU B., ZHOU S.L., DING F., QUALITY CHARACTERISTICS OF SOYBEAN GERM OIL OBTAINED BY INNOVATIVE SUBCRITICAL BUTANE EXPERIMENTAL EQUIPMENT, QUAL. ASSUR. SAF. CROP. FOODS, 8, PP. 369-377, (2016); WONGWAIWECH D., WEERAWATANAKORN M., THARATHA S., HO C.T., COMPARATIVE STUDY ON AMOUNT OF NUTRACEUTICALS IN BY-PRODUCTS FROM SOLVENT AND COLD PRESSING METHODS OF RICE BRAN OIL PROCESSING, J. FOOD DRUG ANAL, 27, PP. 71-82, (2019); AOCS OFFICIAL METHOD: ACID VALUE, OFFICIAL METHODS AND RECOMMENDED PRACTICES OF AMERICAN OIL CHEMIST′ S SOCIETY, (2003); AOCS OFFICIAL METHOD CD 8-53: PEROXIDE VALUE, OFFICIAL METHODS AND RECOMMENDED PRACTICES OF AMERICAN OIL CHEMIST′ S SOCIETY, (1997); GUTFINGER T., POLYPHENOLS IN OLIVE OILS, J. AM. OIL CHEM. SOC. VOL, 58, PP. 966-968, (1981); BRAND-WILLIAMS W., CUVELIER M.E., BERSET C., USE OF A FREE RADICAL METHOD TO EVALUATE ANTIOXIDANT ACTIVITY, LWT—FOOD SCI. TECHNOL, 28, PP. 25-30, (1995); BENZIE I.F.F., STRAIN J.J., THE FERRIC REDUCING ABILITY OF PLASMA (FRAP) AS A MEASURE OF “ANTIOXIDANT POWER”: THE FRAP ASSAY, ANAL. BIOCHEM, 239, PP. 70-76, (1996); THANH T.T., VERGNES M.F., KALOUSTIAN J., EL-MOSELHY T.F., AMIOT-CARLIN M.J., PORTUGAL H., EFFECT OF STORAGE AND HEATING ON PHYTOSTEROL CONCENTRATIONS IN VEGETABLE OILS DETERMINED BY GC/MS, J. SCI. FOOD AGRIC, 86, PP. 220-225, (2006)","M. WEERAWATANAKORN; DEPARTMENT OF AGRO-INDUSTRY, NARESUAN UNIVERSITY, PHITSANULOK, 99 MOO 9, THA PHO, MUEANG, 65000, THAILAND; EMAIL: MONTHANAC@NU.AC.TH","MDPI","ENGLISH","MOLECULES","ARTICLE","ISI","2-S2.0-85151110957","MOLECULES","RAJAMANGALA UNIVERSITY OF TECHNOLOGY LANNA TAK;NARESUAN UNIVERSITY;RUTGERS UNIVERSITY;HUANGGANG NORMAL UNIVERSITY;NARESUAN UNIVERSITY;NARESUAN UNIVERSITY;NARESUAN UNIVERSITY;NATIONAL TAIWAN UNIVERSITY;NARESUAN UNIVERSITY","NOTREPORTED;NARESUAN UNIVERSITY;NOTREPORTED",NA,"WONGWAIWECH D, 2023, MOLECULES","WONGWAIWECH D, 2023, MOLECULES"
"ESTIASIH T;AHMADI K;WIDYANINGSIH T;MALIGAN J;MUBAROK A;ZUBAIDAH E;MUKHLISIYYAH J;PUSPITASARI R","ESTIASIH, TETI (55622661500); AHMADI, KGS. (55622638800); WIDYANINGSIH, TRI DEWANTI (55900709900); MALIGAN, JAYA MAHAR (55900593300); MUBAROK, AHMAD ZAKI (57194546694); ZUBAIDAH, ELOK (55874719600); MUKHLISIYYAH, JHAUHAROTUL (55875732600); PUSPITASARI, RISMA (55875051500)","BIOACTIVE COMPOUNDS OF PALM FATTY ACID DISTILLATE PFAD FROM SEVERAL PALM OIL REFINERIES",2013,"ADVANCE JOURNAL OF FOOD SCIENCE AND TECHNOLOGY","5","6",20,"10.19026/ajfst.5.3074","DEPARTMENT OF FOOD SCIENCE AND TECHNOLOGY, FACULTY OF AGRICULTURAL TECHNOLOGY, BRAWIJAYA UNIVERSITY, MALANG, JAWA TIMUR, 65145, JL. VETERAN, INDONESIA;DEPARTMENT OF AGROINDUSTRY TECHNOLOGY, FACULTY OF AGRICULTURE, TRIBHUWANA TUNGGADEWI UNIVERSITY, MALANG, JAWA TIMUR, 6514, JL. TELAGA WARNA, TLOGOMAS, INDONESIA;DEPARTMENT OF FOOD SCIENCE AND TECHNOLOGY, FACULTY OF AGRICULTURAL TECHNOLOGY, BRAWIJAYA UNIVERSITY, MALANG, JAWA TIMUR, 65145, JL. VETERAN, INDONESIA;DEPARTMENT OF FOOD SCIENCE AND TECHNOLOGY, FACULTY OF AGRICULTURAL TECHNOLOGY, BRAWIJAYA UNIVERSITY, MALANG, JAWA TIMUR, 65145, JL. VETERAN, INDONESIA;DEPARTMENT OF FOOD SCIENCE AND TECHNOLOGY, FACULTY OF AGRICULTURAL TECHNOLOGY, BRAWIJAYA UNIVERSITY, MALANG, JAWA TIMUR, 65145, JL. VETERAN, INDONESIA;DEPARTMENT OF FOOD SCIENCE AND TECHNOLOGY, FACULTY OF AGRICULTURAL TECHNOLOGY, BRAWIJAYA UNIVERSITY, MALANG, JAWA TIMUR, 65145, JL. VETERAN, INDONESIA;DEPARTMENT OF FOOD SCIENCE AND TECHNOLOGY, FACULTY OF AGRICULTURAL TECHNOLOGY, BRAWIJAYA UNIVERSITY, MALANG, JAWA TIMUR, 65145, JL. VETERAN, INDONESIA;DEPARTMENT OF FOOD SCIENCE AND TECHNOLOGY, FACULTY OF AGRICULTURAL TECHNOLOGY, BRAWIJAYA UNIVERSITY, MALANG, JAWA TIMUR, 65145, JL. VETERAN, INDONESIA","THIS RESEARCH STUDIED THE CHARACTERISTICS OF PALM FATTY ACIDS DISTILLATES (PFADS) FROM SEVERAL PALM OIL REFINERIES. IT WAS AIMED TO KNOW THE POTENCY OF PFAD AS BIOACTIVE COMPOUNDS SOURCE, INCLUDING VITAMIN E (MAINLY TOCOTRIENOLS), PHYTOSTEROLS, SQUALENE AND POSSIBLY CO-ENZYME Q10 AND POLYCOSANOL. SAMPLING WAS CONDUCTED AT 6 PALM OIL REFINERIES. THE RESULTS SHOWED THAT PFAD WAS DOMINATED BY FREE FATTY ACIDS OF 85-95% WITH LOW OXIDATION LEVEL INDICATED BY PEROXIDE VALUE OF 1-10 MEQ/KG AND ANISIDIN VALUE OF 6-31. BIOACTIVE COMPOUNDS FOUND WERE VITAMIN E 60-200 PPM, PHYTOSTEROLS 400-7500 PPM AND SQUALENE 400-2800 PPM, MEANWHILE POLYCOSANOL AND CO-ENZYME Q10 WERE NOT FOUND. VITAMIN E WAS DOMINATED BY TOCOTRIENOLS AND ? TOCOTRIENOL WAS THE MAJOR VITAMIN E, FOLLOWED BY A AND D TOCOTRIENOLS. PHYTOSTEROLS IN PFADS FROM SEVERAL PALM OIL REFINERIES HAD VARIETY IN QUANTITY AND COMPOSITION. GENERALLY IT WAS DOMINATED BY ß SITOSTEROL, FOLLOWED BY STIGMASTEROL AND CAMPESTEROL.","CO-ENZYME Q10; PALM FATTY ACID DISTILLATE; PALM OIL REFINERY; PHYTOSTEROL; SQUALENE; TOCOPHEROL; TOCOTRIENOL","ALCOHOLS; ENZYMES; FATTY ACIDS; OIL SHALE; PETROLEUM REFINERIES; OIL REFINERIES; PALM FATTY ACID DISTILLATE; PHYTOSTEROL; SQUALENE; TOCOPHEROL; TOCOTRIENOLS; PALM OIL","","","AFFANDI M.S.Y., REFINING AND DOWNSTREAMING PROCESSING OF PALM AND PALM KERNEL OILS: PROCESSING OF PALM AND PALM KERNEL OILS, IN SELECTED READINGS ON PALM OIL AND ITS USES EDITED BY TECHNICAL COMMITEE OF 1995 PALM OIL FAMILIARIZATION PROGRAMME, PP. 35-59, (1994); OFFICIAL METHODS AND RECOMMENDED PRACTICES OF THE AMERICAN OIL CHEMISTRY SOCIETY. 4TH (ED.), (1990); AWAD A.B., FINK C.S., PHYTOSTEROL AS ANTICANCER DIETARY COMPONENT: EVIDENCE AND MECHANISM OF ACTION, J. NUTR., 130, PP. 2127-2130, (2000); AWIKA J.M., ROONEY L.W., SORGHUM PHYTOCHEMICALS AND THEIR POTENTIAL IMPACT ON HUMAN HEALTH, PHYTOCHEMISTRY, 65, PP. 1199-1221, (2004); BALL G.F.M., FAT-SOLUBLE VITAMIN ASSAYS IN FOOD ANALYSIS (A COMPREHENSIVE REVIEW), (1988); BENITES C.I., CHONCA V.O.C., REIS S.M.P.M., DE OLIVEIRRA O.C., PHYSIOCHEMICAL CHARACTERIZATION OF SOYBEAN OIL DEODORIZER DISTILLATE, CHEM. ENG.TRANS., 17, PP. 903-908, (2009); BONDIOLI P., MARIANI C., LANZANI A., FEDELI E., MULLER A., SQUALENE RECOVERY FROM OLIVE OIL DEODORIZER DISTILLATES, J. AM. OIL CHEM. SOC., 70, 8, (1993); CARR T.P., ASH M.M., BROWN A.W., CHOLESTEROL-LOWERING PHYTOSTEROLS: FACTORS AFFECTING THEIR USE AND EFFICACY, NUT. DIETARY SUPPL., 2, PP. 59-72, (2010); CERIANI R., MEIRELLES A.J.A., SIMULATION OF CONTINUOUS DEODORIZER: EFFECTS ON PRODUCT STREAMS, J. AM. OIL CHEM. SOC., 81, 11, PP. 1059-1069, (2004); CHEAH K.Y., TOH T.S., KOH P.M., PALM FATTY ACID DISTILLATE BIODIESEL: NEXT GENERATION PALM BIODIESEL, (2010); CHU B.S., QUEK S.Y., BAHARIN B.S., OPTIMISATION OF ENZYMATIC HYDROLYSIS FOR CONCENTRATION OF VITAMIN E IN PALM FATTY ACID DISTILLATE, J. FOOD CHEM., 80, 3, PP. 295-302, (2003); ESTIASIH T., CHOLIS M.N., HEPATOPROTECTIVE EFFECT OF TOCOTRIENOL RICH FRACTION FROM PALM FATTY ACID DISTILLATE ON HIGHLY OXIDIZED FRYING OIL INDUCED PEROXIDATION RATS, (2012); GAPOOR A., HASSAN W.H.W., SULONG M., PHYTOCHEMICAL FOR NUTRACEUTICAL FROM THE BY PRODUCT OF PALM OIL REFINING, PALM OIL DEVELOP., 36, PP. 13-19, (2002); GOH S.H., GEE P.T., NONCAROTENOIDS HYDROCARBON IN PALM OIL AND PALM FATTY ACID DISTILLATE, J. AM. OIL CHEM. SOC., 63, 2, PP. 226-230, (1985); HEINONEN M., PIIRONEN V., THE TOCOTRIENOL AND VITAMIN E CONTENT OF THE AVERAGE FINNISH DIET, INT. J. VITAM. NUTR. RES., 61, 1, PP. 27-32, (1991); HILLS G., THIEL C.C., THE FRRIC THYOCYANATE METHOD OF ESTIMATING PEROXIDE IN THE FAT OF BUTTER, MILK AND DRIED MILK, J. DAIRY RES., 14, 3, PP. 340-353, (1946); ANIMAL AND VEGETABLE FATS AND OILS-DETERMINATION OF ANISIDINE VALUE., (2006); JAIN R., JINDAL K.C., PATIL C.S., PHARMACEUTICAL COMPOSITIONS CONTAINING LONG CHAIN FATTY ACIDS AS EXCIPIENTS AS WELL AS PROCESS FOR MANUFACTURING THE SAME, (2007); KASSIS A.N., EVALUATION OF CHOLESTEROL-LOWERING AND ANTIOXIDANT PROPERTIES OF SUGAR CANE POLICOSANOLS IN HAMSTERS AND HUMANS, (2008); KHATOON S., RAJA R.G.R., KRISHNA A.G.G., PHYSICOCHEMICAL CHARACTERISTICS AND COMPOSITION OF INDIAN SOYBEAN OIL DEODORIZER DISTILLATE AND THE RECOVERY OF PHYTOSTEROLS, J. AM. OIL CHEM. SOC., 87, 3, PP. 321-326, (2010); LEWIS J., PROCESS FOR THE PRODUCTION OF TOCOTRIENOL, (2001); LIU D., SHI J., POSADA L.R., KAKUDA Y., XUE S.J., SEPARATING TOCOTRIENOL FROM PALM OIL BY MOLECULAR DISTILLATION, FOOD REV. INT., 24, 4, PP. 376-391, (2008); LOGANATHAN R., SELVADURAY K.R., RADHAKRISHNAN A., NESARETNAM K., PALM OIL RICH IN HEALTH PROMOTING PHYTONUTRIENTS, PALM OIL DEVELOP., 50, PP. 16-25, (2009); MAHENDRA K., MURTHY Y.L.N., RAO C.V.N., KRISHNA B.M., DETERMINATION OF UBIQUINONE Q10 (COENZYME Q10) AND ITS SYNTHESIS RELATED IMPURITIES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) AND MASS SPECTROMETRY (MS), INT. J. PHARMA TECH. RES., 3, 3, PP. 1467-1477, (2011); MENDEZ E., BLANCO M., LAGUNA A., GARCIA E., ISOLATION AND CHARACTERIZATION OF A MIXTURE OF HIGHER PRIMARY ALIPHATIC ALCOHOLS OF HIGH MOLECULAR WEIGHT FROM HENEQUEN (AGAVE FURCROYDES L.) WAX, REVISTA CENIC CIENCIAS QUÍMICAS, 34, 1, PP. 35-38, (2003); NANDI S., SARBANI G., GOSH S., LIPASE CATALYZED SYNTHESIS OF NEUTRAL GLYSERIDES RICH IN MICRONUTRIENTS FROM RICE BRAN OIL FATTY ACIDS DISTILLATE, J. OLEO SCI., 57, 11, PP. 599-603, (2008); NANG H.L.L., WAFTI N.S.A., MAY C.Y., PALM FATTY ACID DISTILLATE, (2009); NEWMARK H.L., SQUALENE, OLIVE OIL AND CANCER RISK: A REVIEW AND HYPOTHESIS, CANCER EPIDEMIOL. BIOMARKER PREV., 6, 12, PP. 1101-1103, (1997); NG M.H., CHAO Y.M., MA A.H., CHOAH C.H., HASHIM M.A., SEPARATION VITAMIN E (TOCOPHEROL, TOCOTRIENOL AND TOCOMONOENAL) IN PALM OIL, LIPIDS, 39, PP. 1031-1035, (2004); PACKER L., WEBER S.U., RIMBACH G., MOLECULAR ASPECTS OF A-TOCOTRIENOL ANTIOXIDANT ACTION AND CELL SIGNALLING, J. NUTR., 131, 2, (2001); PIIRON V., LINDSAY D.G., MIEYYINEN T.A., TOIVO J., LAMPI A.M., PLANT STEROL: BIOSYNTHESIS, BIOLOGICAL FUNCTION AND THEIR IMPORTANCE TO HUMAN NUTRITION, J. SCI. FOOD AGRIC., 80, 7, PP. 939-966, (2000); POSADA L.R., SHI J., KAKUDA Y., XUE S.J., EXTRACTION OF TOCOTRIENOLS FROM PALM FATTY ACID DISTILLATES USING MOLECULAR DISTILLATION, J. SEPAR. PURIF. TECHNOL., 57, 2, PP. 220-229, (2007); PRAKASH I., DUBOIS G.E., HIGH SWEETENER COMPOSITION WITH LONG-CHAIN PRIMARY ALIPHATIC SATURATED ALCOHOL AND COMPOSITIONS SWEETENED THEREWITH, (2007); PUAH C.W., MAY C.Y., AHNGAN M., HOCK C.C., DEGUMMING AND BLEACHING: EFFECT ON SELECTED CONSTITUENTS OF PALM OIL, J.OIL PALM RES., 16, PP. 57-63, (2004); RAKMI A.R., HERAWAN T., PROPERTIES OF BIOSURFACTANT ENZYMATICALLY PREPARED FROM FRUCTOSE AND PALM FATTY ACID, J. OIL PALM RES., 12, 1, PP. 117-122, (2000); SERBINOVA E.A., PACKER L., ANTIOXIDANT PROPERTIES OF Α- TOCOPHEROL AND Α-TOCOTRIENOL, METHODS ENZYMOL., 234, PP. 354-366, (1994); SOMAIYA S.S., SRIVASTAVA S., GHAH S., MULIK N., A METHOD OF OBTAINING POLICOSANOLS FROM NATURAL MATERIAL, WORLD INT. PROPERTY ORGNIZ., (2010); TASAN M., BILGIN B., GECGEL U., DEMIRCI A.S., PHYTOSTEROLS AS FUNCTIONAL FOOD INGREDIENTS, J. TEKIRDAG AGRIC. FACULTY, 3, 2, PP. 153-159, (2006); THERIAULT A., CHAO J.T., WANG Q., GAPOR A., ADELI K., TOCOTRIENOL: A REVIEW OF ITS THERAPEUTIC POTENTIAL, CLIN. BIOCHEM., 32, 5, PP. 309-319, (1999); WAN J., ZHANG W., JIANG B., GUO Y., HU C., SEPARATION OF INDIVIDUAL TO COPHEROLS FROM SOYBEAN DISTILLATE BY LOW PRESSURE COLUMN CHROMATOGRAPHY, J. AM. OIL CHEM. SOC., 85, 4, PP. 331-338, (2008); WINKLE-MOSER J.K., VAUGHN S.F., ANTIOXIDANT ACTIVITY OF PHYTOCHEMICLAS FROM DITILLERS DRIED GRAIN OILS, J. AM. OIL CHEM. SOC., 86, 11, PP. 1073-1082, (2009)","","MAXWELL SCIENCE PUBLICATIONS","ENGLISH","ADV. J. FOOD SCI. TECHNOL.","ARTICLE","ISI","2-S2.0-84885145875","ADV J FOOD SCI TECHNOL",NA,"NOTREPORTED",NA,"ESTIASIH T, 2013, ADV J FOOD SCI TECHNOL","ESTIASIH T, 2013, ADV J FOOD SCI TECHNOL"
"TUNG C;CHANG Y;LEE S;CHU Y","TUNG, CHIH-HONG (23502516700); CHANG, YUN-PING (55511080900); LEE, SHIN-MEI (7601403859); CHU, YAN-HWA (7403050985)","EXTRACTION OF FUNCTIONAL COMPOUNDS FROM SORGHUM DISTILLERY RESIDUES",2010,"TAIWANESE JOURNAL OF AGRICULTURAL CHEMISTRY AND FOOD SCIENCE","48","5",0,"","FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE, HSINCHU, TAIWAN;FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE, HSINCHU, TAIWAN;DEPARTMENT OF FOOD SCIENCE, NATIONAL KINMEN INSTITUTE OF TECHNOLOGY, TAIWAN;FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE, HSINCHU, TAIWAN","SOLVENT AND SUPERCRITICAL CARBON DIOXIDE WERE USED TO EXTRACT THE FUNCTIONAL COMPOUNDS, INCLUDING POLYCOSANOLS, PHYTOSTEROLS, TOTAL PHENOLIC COMPOUNDS AND TANNINS, FROM SORGHUM DISTILLERY RESIDUES (SDR), RESPECTIVELY. RESULTS SHOWED THAT USING ETHANOL, ETHYL ACETATE AND N-HEXANE AS EXTRACTION SOLVENTS, THE EXTRACTION YIELDS OF POLICOSANOLS WERE 348, 322 AND 275 MG/KG SDR, AND THOSE OF PHYTOSTEROLS WERE 317, 311 AND 323 MG/KG SDR. USING 50% ETHANOL AS EXTRACTION SOLVENT, EXTRACTION YIELDS OF TOTAL PHENOLIC COMPOUNDS (TPC) AND TANNINS WERE THE HIGHEST AMONG ALL EXTRACTION, AND THE DPPH SCAVENGING ABILITY OF THE EXTRACT WAS ALSO HIGHER THAN THOSE OBTAINED BY USING OTHER SOLVENTS. BY USING SUPERCRITICAL CARBON DIOXIDE TO EXTRACT SDR, AN INCREASE IN TEMPERATURE WOULD RESULT IN A HIGHER YIELDS OF POLICOSANOLS, PHYTOSTEROLS, TOTAL PHENOLIC COMPOUNDS AND TANNINS, BUT THIS EFFECT WAS LEVELED OFF WHEN THE TEMPERATURE IS HIGHER THAN 65°C. THE POLICOSANOLS AND PHYTOSTEROLS EXTRACTION YIELDS COULD REACH 273 MG AND 516 MG, RESPECTIVELY, AT THE CONDITION OF 65°C/379 BAR SUPERCRITICAL CARBON DIOXIDE EXTRACTION FOR 3 H. AFTER SEPARATION, THE POLICOSANOLS CONTENT OF THE EXTRACT WAS 2.16% HIGHER THAN THAT OF N-HEXANE SOLVENT EXTRACT WITH 0.94% OF POLICOSANOLS CONTENT.","POLICOSANOL; SORGHUM DISTILLERY RESIDUES; SUPERCRITICAL CARBON DIOXIDE EXTRACTION","","","","WANG L., WELLER C.L., SCHLEGEL V.L., CARR T.P., CUPPETT S.L., SUPERCRITICAL CO2 EXTRACTION OF LIPIDS FROM GRAIN SORGHUM DRIED DISTILLERS GRAINS WITH SOLUBLES, BIORESOUR. TECHNOL., 99, PP. 1373-1382, (2008); AWIKA J.M., ROONEY L.W., SORGHUM PHYTOCHEMICALS AND THEIR POTENTIAL IMPACT ON HUMAN HEALTH, PHYTOCHEM., 65, PP. 1199-1221, (2004); KATAN M.B., GRUNDY S.M., JONES P., LAW M., MIETTINEN T., PAOLETTI R., EFFICACY AND SAFETY OF PLANT STANOLS AND STEROLS IN THE MANAGEMENT OF BLOOD CHOLESTEROL LEVELS, MAYO CLIN. PROC., 78, PP. 965-978, (2003); TAYLOR J.R.N., SCHOBER T.J., BEAN S.R., NOVEL FOOD AND NON-FOOD USES FOR SORGHUM AND MILLETS, J. CEREAL SCI., 44, PP. 252-271, (2006); BERNARDO-GIL M.G., GRENHA J., SANTOS J., CARDOSO P., SUPERCRITICAL FUID EXTRACTION AND CHARACTERIZATION OF OIL FROM HAZELNUT, EUR. J. LIPID SCI. TECHNOL., 104, PP. 402-409, (2002); COELHO J.A.P., PEREIRA A.P., MENDES R.L., PALAVRA A.M.F., SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF FOENICULUM VULGARE VOLATILE OIL, FLAVOR FRAGRANCE J., 18, PP. 316-319, (2003); MARONGIU B., PORCEDDA S., CAREDDA A.D., GIOANNIS B., VARGIU L., COLLA P., EXTRACTION OF JUNIPERUS OXYCEDRUS SSP. OXYCEDRUS ESSENTIAL OIL BY SUPERCRITICAL CARBON DIOXIDE: INFLUENCE OF SOME PROCESS PARAMETERS AND BIOLOGICAL ACTIVITY, FLAVOR FRAGRANCE J., 18, PP. 390-397, (2003); GIANNUZZO A.N., BOGGETTI H.J., NAZARENO M.A., MISHIMA H.T., SUPERCRITICAL FUID EXTRACTION OF NARINGIN FROM THE PEEL OF CITRUS PARADISE, PHYTOCHEM. ANAL., 14, PP. 221-223, (2003); ELLINGTON E., BASTIDA J., VILADOMAT F., CODINA C., SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF COLCHICINES AND RELATED ALKALOIDS FROM SEEDS OF COLCHICUM AUTUMNALE L, PHYTOCHEM. ANAL., 14, PP. 164-169, (2003); HAMBURGER M., BAUMANN D., ADLER S., SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF SELECTED MEDICINAL PLANTSEFFECTS OF HIGH PRESSURE AND ADDED ETHANOL ON YIELD OF EXTRACTED SUBSTANCES, PHYTOCHEM. ANAL., 15, PP. 46-54, (2004); HOI J.T., WELLER C.L., SCHLEGEL V.L., CUPPETT S.L., LEE J.Y., CARR T.P., SORGHUM DISTILLERS DRIED GRAIN LIPID EXTRACT INCREASES CHOLESTEROL EXCRETION AND DECREASES PLASMA AND LIVER CHOLESTEROL CONCENTRATION IN HAMSTERS, J. FUNCT. FOODS, 1, PP. 381-386, (2009); CHEN F., WANG Z.F., ZHAO G.H., LIAO X.J., CAI T.Y., GUO L.Y., HU X.S., PURIFICATION PROCESS OF OCTACOSANOL EXTRACTS FROM RICE BRAN WAX BY MOLECULAR DISTILLATION, J. FOOD ENG., 79, PP. 63-68, (2007); KAHKONEN M.P., HOPIA A.I., VUORELA H.J., RAUHA J., PIHLAJA P.K., KUJALA T.S., HEINONEN M., ANTIOXIDANT ACTIVITY OF PLANT EXTRACTS CONTAINING PHENOLIC COMPOUNDS, J. AGRIC. FOOD CHEM., 47, PP. 3954-3962, (1999); PRICE M.L., VAN SCOYOCAND S., BULTER L., A CRITICAL EVALUATION OF THE VANILLIN REACTION AS AN ASSAY FOR TANNIN IN SORGHUM GRAIN, J. AGRIC. FOOD CHEM., 26, PP. 1214-1218, (1978); SHIMADA K., FUJIKAWA K., YAHARA K., NAKAMURA T., ANTIOXIDATIVE PROPERTIES OF XANTHAN ON THE AUTOXIDATION OF SOYBEAN OIL IN CYCLODEXTRIN EMULSION, J. AGRIC. FOOD CHEM., 40, PP. 945-948, (1992); HOLSER R.A., AKIN D.E., EXTRACTION OF LIPIDS FROM FLAX PROCESSING WASTE USING HOT ETHANOL, IND. CROPS PROD., 27, PP. 236-240, (2008); XI J., SHEN D.J., ZHAO S., LU B.B., LI Y., ZHANG R., CHARACTERIZATION OF POLYPHENOLS FROM GREEN TEA LEAVES USING A HIGH HYDROSTATIC PRESSURE EXTRACTION, INT. J. PHARM., 382, PP. 139-143, (2009); MARKOM M., HASAN M., RAMLI W., DAUD W., SINGH H., JAHIM J.M., EXTRACTION OF HYDROLYSABLE TANNINS FROM PHYLLANTHUS NIRURI LINN.: EFFECTS OF SOLVENTS AND EXTRACTION METHODS, SEP. PURIF. TECHNOL., 52, PP. 487-496, (2007); THOMAS J.B., JAMES F.E., SUPERCRITICAL FLUID TECHNOLOGY: REVIEW IN MODERN THEORY AND APPLICATIONS, (1991); MORRISON W.H., HOLSER R., AKIN D.E., CUTICULAR WAX FROM FAX PROCESSING WASTE WITH HEXANE AND SUPER CRITICAL CARBON DIOXIDE EXTRACTIONS, IND. CROPS PROD., 24, PP. 119-122, (2006)","C.-H. TUNG; FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE, HSINCHU, TAIWAN; EMAIL: DJH@FRDI.ORG.TW","","CHINESE","TAIWANESE J. AGRIC. CHEM. FOOD SCI.","ARTICLE","ISI","2-S2.0-84870504541","TAIWANESE J AGRIC CHEM FOOD SCI","FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE;FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE;NATIONAL KINMEN INSTITUTE OF TECHNOLOGY;FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE","NOTREPORTED;FOOD INDUSTRY RESEARCH AND DEVELOPMENT INSTITUTE;NOTREPORTED",NA,"TUNG C-H, 2010, TAIWANESE J AGRIC CHEM FOOD SCI","TUNG C-H, 2010, TAIWANESE J AGRIC CHEM FOOD SCI"
"KAEWKOOL P;KRISNANGKURA K","KAEWKOOL, PHATTARAPORN (26653550900); KRISNANGKURA, KANIT (6701651738)","TRANSESTERIFICATIONACETYLATION OF LONG CHAIN ALCOHOLS WITH ALKYL ACETATE",2010,"CHEMISTRY AND PHYSICS OF LIPIDS","163","3",6,"10.1016/j.chemphyslip.2010.06.003","DEPARTMENT OF AGRICULTURE AND ENVIRONMENT, FACULTY OF SCIENCE AND TECHNOLOGY, SURINDRA RAJAPAT UNIVERSITY, MUANG, SURIN 32000, THAILAND;THAILAND","GAS CHROMATOGRAPHIC CHARACTERIZATIONS OF FATTY ALCOHOLS ARE GENERALLY CARRIED OUT AS THE FREE ALCOHOLS, TRIMETHYL SILYL OR ACETYL DERIVATIVES. IN THIS STUDY, TRANSESTERIFICATION/ACETYLATION OF LONG CHAIN FATTY ALCOHOLS IS SIMPLY CARRIED OUT BY DISSOLVING THE ALCOHOL IN ETHYL/METHYL ACETATE AND PASSING THROUGH A MICRO-COLUMN PACKED WITH SOLID NAOH. REACTION TIMES ARE SLIGHTLY DIFFERENT FOR ALCOHOLS OF DIFFERENT CHAIN LENGTH. RICE BRAN ALCOHOLS OF 24-34 CARBON ATOM ARE SUCCESSFULLY ACETYLATED. ALSO, CASTOR OIL METHYL ESTER CAN BE INTERESTERIFIED BUT WITH LONGER REACTION TIME. © 2010 ELSEVIER IRELAND LTD. ALL RIGHTS RESERVED.","CASTOR OIL; FATTY ALCOHOL; POLICOSANOL; TRANSACETYLATION; TRANSESTERIFICATION","ACETATES; ACETYLATION; CASTOR OIL; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, GEL; ESTERIFICATION; FATTY ALCOHOLS; ACETIC ACID; ACETIC ACID ETHYL ESTER; ALCOHOL DERIVATIVE; CASTOR OIL; FATTY ALCOHOL; ACETYLATION; ARTICLE; GAS CHROMATOGRAPHY; PRIORITY JOURNAL; REACTION TIME; RICE BRAN; TRANSESTERIFICATION","THAILAND RESEARCH FUND, TRF","THIS WORK WAS SUPPORTED BY THAILAND RESEARCH FUND.","BONADUCE I., COLOMBINI M.P., CHARACTERISATION OF BEESWAX IN WORKS OF ART BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY AND PYROLYSIS-GAS CHROMATOGRAPHY-MASS SPECTROMETRY PROCEDURES, J. CHROMATOGR. A, 1028, PP. 297-306, (2004); CHEN F., YAN H., CAI T.Y., QUANTITATIVE ANALYSIS OF OCTACOSANOL AND TRIACONTANOL IN EXTRACTS OF HIGHER FATTY ALCOHOLS BY GC, FOOD SCI., 24, PP. 119-121, (2003); CHEN F., WANG Z., ZHAO G., LIAO X., CAI T., GUO L., HU X., PURIFICATION PROCESS OF OCTACOSANOL EXTRACTS FROM RICE BRAN WAX BY MOLECULAR DISTILLATION, J. FOOD ENG., 79, PP. 63-68, (2007); IRMAK S., DUNFORD N.T., MILLIGAN J., POLICOSANOL CONTENTS OF BEESWAX, SUGAR CANE AND WHEAT EXTRACTS, FOOD CHEM., 95, PP. 312-318, (2006); JEYASHOKE N., KRISNANGKURA K., CHEN S.-T., MICROWAVE INDUCED RAPID TRANSMETHYLATION OF FATTY ACIDS FOR ANALYSIS OF FOOD OIL, J. CHROMATOGR. A, 818, PP. 133-137, (1998); KAEWKOOL P., KITTIRATANAPIBOON K., ARYUSUK K., KRISNANGKURA K., MICRO-REACTOR FOR TRANSESTERIFICATION OF PLANT SEED OILS, EUR. J. LIPID SCI. TECHNOL., 111, PP. 474-480, (2009); KITTIRATTANAPIBOON K., KRISNANGKURA K., SEPARATION OF ACYLGLYCEROLS, FAME AND FFA IN BIODIESEL BY SIZE EXCLUSION CHROMATOGRAPHY, EUR. J. LIPID SCI. TECHNOL., 110, PP. 422-427, (2008); KOVAL L.I., DZYUBA V.I., ILNITSKA O.L., PEKHNYO V.I., EFFICIENT TRANSESTERIFICATION OF ETHYL ACETOACETATE WITH HIGHER ALCOHOLS WITHOUT CATALYSTS, TETRAHEDRON LETT., 49, PP. 1645-1647, (2008); LERTSATHAPORNSUK V., PAIRINTRA R., ARYUSUK K., KRISNANGKURA K., MICROWAVE ASSISTED IN CONTINUOUS BIODIESEL PRODUCTION FROM WASTE FRYING PALM OIL AND ITS PERFORMANCE IN A 100 KW DIESEL GENERATOR, FUEL PROCESS. TECHNOL., 89, PP. 1330-1336, (2008); MA F., HANNA M.A., BIODIESEL PRODUCTION: A REVIEW, BIORESOUR. TECHNOL., 70, PP. 1-15, (1999); OLIARO-BOSSO S., CALCIO GAUDINO E., MANTEGNA S., GIRAUDO E., MEDA C., VIOLA F., CRAVOTTO G., REGULATION OF HMGCOA REDUCTASE ACTIVITY BY POLICOSANOL AND OCTACOSADIENOL, A NEW SYNTHETIC ANALOGUE OF OCTACOSANOL, LIPIDS, 44, PP. 907-916, (2009); RIES S.K., WERT V., SWEELEY C.C., LEAVITT R.A., TRIACONTANOL: A NEW NATURALLY OCCURRING PLANT GROWTH REGULATOR, SCIENCE, 195, PP. 1339-1341, (1977); SHIRAE Y., MINO T., HASEGAWA T., SAKAMOTO M., FUJITA T., TRANSESTERIFICATION OF VARIOUS ALCOHOLS WITH VINYL ACETATE UNDER MILD CONDITIONS CATALYZED BY DIETHYLZINC USING N-SUBSTITUTED DIETHANOLAMINE AS A LIGAND, TETRAHEDRON LETT., 46, PP. 5877-5879, (2005); STAPP P.R., RABJOHN N., LITHIUM ALUMINUM ALKOXIDE CATALYZED TRANSESTERIFICATION OF PRIMARY ALCOHOLS WITH ETHYL ACETATE, J. ORG. CHEM., 24, PP. 1798-1800, (1959); TAYLOR J.C., RAPPORT L., LOCKWOOD G.B., OCTACOSANOL IN HUMAN HEALTH, NUTRITION, 19, PP. 192-195, (2003); VIOLA F., OLIARO S., BINELLO A., CRAVOTTO G., POLICOSANOL: UPDATING AND PERSPECTIVES, MEDITERR. J. NUTR. METAB., 1, PP. 77-83, (2008); WANG M.F., LIAN H.Z., MAO L., ZHOU J.P., GONG H.J., QIAN B.Y., FANG Y., LI J., COMPARISON OF VARIOUS EXTRACTION METHODS FOR POLICOSANOL FROM RICE BRAN WAX AND ESTABLISHMENT OF CHROMATOGRAPHIC FINGERPRINT OF POLICOSANOL, J. AGRIC. FOOD CHEM., 55, PP. 5552-5558, (2007)","K. KRISNANGKURA; BIOCHEMICAL TECHNOLOGY DIVISION, SCHOOL OF BIORESOURCES AND TECHNOLOGY, KING MONGKUT'S UNIVERSITY OF TECHNOLOGY THONBURI, TAKHAM, BANGKHUNTIEN, BANGKOK 10150, 49, TIENTALAY 25 RD., THAILAND; EMAIL: KANIT.KRI@KMUTT.AC.TH","","ENGLISH","CHEM. PHYS. LIPIDS","ARTICLE","ISI","2-S2.0-77956265191","CHEM PHYS LIPIDS","SURINDRA RAJAPAT UNIVERSITY","NOTREPORTED;KING MONGKUT'S UNIVERSITY OF TECHNOLOGY THONBURI;NOTREPORTED",NA,"KAEWKOOL P, 2010, CHEM PHYS LIPIDS","KAEWKOOL P, 2010, CHEM PHYS LIPIDS"
"WONGWAIWECH D;WEERAWATANAKORN M;BOONNOUN P","WONGWAIWECH, DONPORN (57202775373); WEERAWATANAKORN, MONTHANA (55976489600); BOONNOUN, PANATPONG (35742804700)","SUBCRITICAL DIMETHYL ETHER EXTRACTION AS A SIMPLE METHOD TO EXTRACT NUTRACEUTICALS FROM BYPRODUCTS FROM RICE BRAN OIL MANUFACTURE",2020,"SCIENTIFIC REPORTS","10","",15,"10.1038/s41598-020-78011-z","DEPARTMENT OF AGRO-INDUSTRY, FACULTY OF AGRICULTURE, NATURAL RESOURCES AND ENVIRONMENT, NARESUAN UNIVERSITY, 99 MOO 9, THA PHO, MUEANG, PHITSANULOK, 65000, THAILAND;DEPARTMENT OF AGRO-INDUSTRY, FACULTY OF AGRICULTURE, NATURAL RESOURCES AND ENVIRONMENT, NARESUAN UNIVERSITY, 99 MOO 9, THA PHO, MUEANG, PHITSANULOK, 65000, THAILAND;DEPARTMENT OF INDUSTRIAL ENGINEERING, CHEMICAL ENGINEERING PROGRAM, FACULTY OF ENGINEERING, NARESUAN UNIVERSITY, 99 MOO 9, THA PHO, MUEANG, PHITSANULOK, 65000, THAILAND","THE BYPRODUCTS OF RICE BRAN OIL PROCESSES ARE A GOOD SOURCE OF FAT-SOLUBLE NUTRACEUTICALS, INCLUDING Γ-ORYZANOL, PHYTOSTEROL, AND POLICOSANOLS. THIS STUDY AIMED TO INVESTIGATE THE EFFECTS OF GREEN TECHNOLOGY WITH LOW PRESSURE AS THE SUBCRITICAL FLUID EXTRACTION WITH DIMETHYL ETHER (SUBFDME) ON THE AMOUNT OF Γ-ORYZANOL, PHYTOSTEROL, AND POLICOSANOL EXTRACTED FROM THE BYPRODUCTS AND TO INCREASE THE PURITY OF POLICOSANOLS. THE SUBFDME EXTRACTION APPARATUS WAS OPERATED UNDER PRESSURES BELOW 1 MPA. COMPARED TO THE CHEMICAL EXTRACTION METHOD, SUBFDME GAVE THE HIGHEST CONTENT OF Γ-ORYZANOL AT 924.51 MG/100 G FROM DEFATTED RICE BRAN, FOLLOWED BY 829.88 MG/100 G FROM THE FILTER CAKE, WHILE THE HIGHEST PHYTOSTEROL CONTENT WAS 367.54 MG/100 G. TRANSESTERIFICATION GAVE THE HIGHEST EXTRACTION YIELD OF 43.71% WITH THE HIGHEST POLICOSANOL CONTENT (30,787 MG/100 G), AND THE SUBFDME METHOD INCREASED THE POLICOSANOL LEVEL FROM TRANSESTERIFIED RICE BRAN WAX TO 84,913.14 MG/100 G. THE RESULTS INDICATE THAT THE SUBFDME METHOD IS A PROMISING TOOL TO EXTRACT Γ-ORYZANOL AND PHYTOSTEROL AND A SIMPLE AND EFFECTIVE TECHNIQUE TO INCREASE THE PURITY OF POLICOSANOL. THE STUDY PRESENTED A NOVEL TECHNIQUE FOR THE POTENTIAL USE OF SUBSFDME AS AN ALTERNATIVE LOW-PRESSURE AND LOW-TEMPERATURE TECHNIQUE TO EXTRACT Γ-ORYZANOL AND PHYTOSTEROL. THE COMBINATION OF TRANSESTERIFICATION AND THE SUBFDME TECHNIQUE IS A POTENTIAL SIMPLE TWO-STEP METHOD TO EXTRACT AND PURIFY POLICOSANOL, WHICH IS BENEFICIAL FOR THE MANUFACTURE OF DIETARY SUPPLEMENTS, FUNCTIONAL FOODS AND PHARMACEUTICAL PRODUCTS. © 2020, THE AUTHOR(S).","","","NATIONAL RESEARCH COUNCIL OF THAILAND, NRCT, (R2562B033); THAILAND SCIENCE RESEARCH AND INNOVATION, TSRI, (FRB630011/0179)","FINANCIAL SUPPORT FOR THIS STUDY WAS PROVIDED BY A RESEARCH GRANT FROM THE NATIONAL RESEARCH COUNCIL OF THAILAND (NO. R2562B033) AND THAILAND SCIENCE RESEARCH AND INNOVATION (FRB630011/0179).","WONGWAIWECH D., WEERAWATANAKORN M., THARATHA S., HO C.T., COMPARATIVE STUDY ON AMOUNT OF NUTRACEUTICALS IN BY-PRODUCTS FROM SOLVENT AND COLD PRESSING METHODS OF RICE BRAN OIL PROCESSING, J. FOOD DRUG ANAL., 27, PP. 71-82, (2019); NIJJAR P.S., BURKE F.M., BLOESCH A., RADER D.J., ROLE OF DIETARY SUPPLEMENTS IN LOWERING LOW-DENSITY LIPOPROTEIN CHOLESTEROL: A REVIEW, J. CLIN. LIPIDOL., 4, PP. 248-258, (2010); PATEL M., NAIK S.N., GAMMA-ORYZANOL FROM RICE BRAN OIL—A REVIEW, J. SCI. IND. RES. (INDIA), 63, PP. 569-578, (2004); UDDIN M.S., ET AL., TECHNIQUES FOR THE EXTRACTION OF PHYTOSTEROLS AND THEIR BENEFITS IN HUMAN HEALTH: A REVIEW, SEP. SCI. TECHNOL., 53, PP. 2206-2223, (2018); WEERAWATANAKORN M., MEEROD K., WONGWAIWECH D., HO C., POLICOSANOLS: CHEMISTRY, OCCURRENCE, AND HEALTH EFFECTS, CURR. PHARMACOL. REP., 5, PP. 131-149, (2019); AFFUSO F., ET AL., A NUTRACEUTICAL COMBINATION IMPROVES INSULIN SENSITIVITY IN PATIENTS WITH METABOLIC SYNDROME, WORLD J. CARDIOL., 4, (2012); HARRABI S., BOUKHCHINA S., MAYER P.M., KALLEL H., POLICOSANOL DISTRIBUTION AND ACCUMULATION IN DEVELOPING CORN KERNELS, FOOD CHEM., 115, PP. 918-923, (2009); OHTA Y., ET AL., OCTACOSANOL ATTENUATES DISRUPTED HEPATIC REACTIVE OXYGEN SPECIES METABOLISM ASSOCIATED WITH ACUTE LIVER INJURY PROGRESSION IN RATS INTOXICATED WITH CARBON TETRACHLORIDE, J. CLIN. BIOCHEM. NUTR., 42, PP. 118-125, (2008); RAVELO Y., ET AL., EVALUATION OF ANTI-INFLAMMATORY AND ANTINOCICEPTIVE EFFECTS OF D-002 (BEESWAX ALCOHOLS), J. NAT. MED., 65, PP. 330-335, (2011); NYAM K.L., TAN C.P., LAI O.M., LONG K., MAN Y.B.C., OPTIMIZATION OF SUPERCRITICAL CO<SUB>2</SUB> EXTRACTION OF PHYTOSTEROL-ENRICHED OIL FROM KALAHARI MELON SEEDS, FOOD BIOPROCESS TECHNOL., 4, PP. 1432-1441, (2011); NYAM K.L., TAN C.P., LAI O.M., LONG K., CHE MAN Y.B., OPTIMIZATION OF SUPERCRITICAL FLUID EXTRACTION OF PHYTOSTEROL FROM ROSELLE SEEDS WITH A CENTRAL COMPOSITE DESIGN MODEL, FOOD BIOPROD. PROCESS., 88, PP. 239-246, (2010); HUNG C.C., WENG Y.M., YU Z.R., WANG B.J., OPTIMAL SELECTIVITY OF Γ-ORYZANOL AND TOTAL PHENOLIC COMPOUNDS FROM RICE BRAN USING SUPERCRITICAL CARBON DIOXIDE FRACTIONATION TECHNIQUE, INT. FOOD RES. J., 26, PP. 639-647, (2019); SAJFRTOVA M., LICKOVA I., WIMMEROVA M., SOVOVA H., WIMMER Z., Β-SITOSTEROL: SUPERCRITICAL CARBON DIOXIDE EXTRACTION FROM SEA BUCKTHORN (HIPPOPHAE RHAMNOIDES L.) SEEDS, INT. J. MOL. SCI., 11, PP. 1842-1850, (2010); SNYDER J.M., KING J.W., TAYLOR S.L., NEESE A.L., CONCENTRATION OF PHYTOSTEROLS FOR ANALYSIS BY SUPERCRITICAL FLUID EXTRACTION, J. AM. OIL CHEM. SOC., 76, PP. 717-721, (1999); EKINCI M.S., GURU M., EXTRACTION OF PHYTOSTEROLS FROM MELON (CUCUMIS MELO) SEEDS BY SUPERCRITICAL CO<SUB>2</SUB> AS A CLEAN TECHNOLOGY, GREEN PROCESS. SYNTH., 8, PP. 677-682, (2019); KANDA H., KAMO Y., MACHMUDAH S., WAHYUDIONO, GOTO M., EXTRACTION OF FUCOXANTHIN FROM RAW MACROALGAE EXCLUDING DRYING AND CELL WALL DISRUPTION BY LIQUEFIED DIMETHYL ETHER, MAR. DRUGS, 12, PP. 2383-2396, (2014); MA Y.-X., ET AL., SUBCRITICAL FLUID EXTRACTION OF CHINESE QUINCE SEED: OPTIMIZATION AND PRODUCT CHARACTERIZATION, MOLECULES, 22, (2017); LU J., FENG X., HAN Y., XUE C., OPTIMIZATION OF SUBCRITICAL FLUID EXTRACTION OF CAROTENOIDS AND CHLOROPHYLL A FROM LAMINARIA JAPONICA ARESCH BY RESPONSE SURFACE METHODOLOGY, J. SCI. FOOD AGRIC., 94, PP. 139-145, (2014); HOSHINO R., WAHYUDIONO, MACHMUDAH S., KANDA H., GOTO M., SIMULTANEOUS EXTRACTION OF WATER AND ESSENTIAL OILS FROM CITRUS LEAVES AND PEELS USING LIQUEFIED DIMETHYL ETHER, J. NUTR. FOOD SCI., 4, PP. 1-5, (2014); SCIENTIFIC OPINION OF THE PANEL ON FOOD CONTACT MATERIALS, ENZYMES, FLAVOURINGS AND PROCESSING AIDS (CEF) ON DIMETHYL ETHER AS AN EXTRACTION SOLVENT, EUR. FOOD SAF. AUTH. J., 984, PP. 1-13, (2009); FURUKAWA H., ET AL., USE OF LIQUEFIED DIMETHYL ETHER FOR THE EXTRACTION OF PROTEINS FROM VEGETABLE TISSUES, SOLVENT EXTR. RES. DEV., 23, PP. 127-135, (2016); ARYUSUK K., WAX: CO-PRODUCT OF RICE BRAN OIL REFINING; SEO I., SHIN H.S., DETERMINATION OF TOLUENE AND OTHER RESIDUAL SOLVENTS IN VARIOUS FOOD PACKAGING MATERIALS BY GAS CHROMATOGRAPHY/MASS SPECTROMETRY (GC/MS), FOOD SCI. BIOTECHNOL., 19, PP. 1429-1434, (2010); GUL K., YOUSUF B., SINGH A.K., SINGH P., WANI A.A., RICE BRAN: NUTRITIONAL VALUES AND ITS EMERGING POTENTIAL FOR DEVELOPMENT OF FUNCTIONAL FOOD—A REVIEW, BIOACT. CARBOHYDR. DIET. FIBRE, 6, PP. 24-30, (2015); RENUKA DEVI R., ARUMUGHAN C., PHYTOCHEMICAL CHARACTERIZATION OF DEFATTED RICE BRAN AND OPTIMIZATION OF A PROCESS FOR THEIR EXTRACTION AND ENRICHMENT, BIORESOUR. TECHNOL., 98, PP. 3037-3043, (2007); DERAKHSHAN-HONARPARVAR M., HAMEDI M.M., PIROUZIFARD M.K., RICE BRAN PHYTOSTEROLS OF THREE WIDESPREAD IRANIAN CULTIVARS, J. AGRIC. SCI. TECHNOL., 12, PP. 167-172, (2010); SAWADIKIAT P., HONGSPRABHAS P., PHYTOSTEROLS AND Γ-ORYZANOL IN RICE BRAN OILS AND DISTILLATES FROM PHYSICAL REFINING PROCESS, INT. J. FOOD SCI. TECHNOL., 49, PP. 2030-2036, (2014); MINGYAI S., KETTAWAN A., SRIKAEO K., SINGANUSONG R., PHYSICOCHEMICAL AND ANTIOXIDANT PROPERTIES OF RICE BRAN OILS PRODUCED FROM COLORED RICE USING DIFFERENT EXTRACTION METHODS, J. OLEO SCI., 572, PP. 565-572, (2017); ISHAKA A., IMAM M.U., MAHAMUD R., ZUKI A.B.Z., MAZNAH I., CHARACTERIZATION OF RICE BRAN WAX POLICOSANOL AND ITS NANOEMULSION FORMULATION, INT. J. NANOMEDICINE, 9, PP. 2261-2269, (2014); PUENGTHAM J., ARYUSUK K., KITTIRATANAPIBOON K., JEYASHOKE N., KRISNANGKURA K., EXTRACTION PURIFICATION AND CHARACTERIZATION OF POLICOSANOL FROM THAI RICE BRAN WAX, KMUTT RES. DEV. J., 31, PP. 305-318, (2008); SHEN J., LUO F., LIN Q., POLICOSANOL: EXTRACTION AND BIOLOGICAL FUNCTIONS, J. FUNCT. FOODS, 57, PP. 351-360, (2019); WANG M.F., ET AL., COMPARISON OF VARIOUS EXTRACTION METHODS FOR POLICOSANOL FROM RICE BRAN WAX AND ESTABLISHMENT OF CHROMATOGRAPHIC FINGERPRINT OF POLICOSANOL, J. AGRIC. FOOD CHEM., 55, PP. 5552-5558, (2007); NING-NING S., HAI-RONG G., GAN-LIN C., GUO-LIANG Y., EXTRACTION OF HIGHER ALIPHATIC ALKANOLS FROM SUGARCANE WAX USING TRANSESTERIFICATION, FOOD RES. DEV., 28, PP. 28-30, (2008); GOTO M., KANDA H., WAHYUDIONO, MACHMUDAH S., EXTRACTION OF CAROTENOIDS AND LIPIDS FROM ALGAE BY SUPERCRITICAL CO<SUB>2</SUB> AND SUBCRITICAL DIMETHYL ETHER, J. SUPERCRIT. FLUIDS, 96, PP. 245-251, (2015); POOJARY M.M., ET AL., INNOVATIVE ALTERNATIVE TECHNOLOGIES TO EXTRACT CAROTENOIDS FROM MICROALGAE AND SEAWEEDS, MAR. DRUGS, 14, PP. 1-34, (2016); MANDAL S.C., MANDAL V., DAS A.K., CLASSIFICATION OF EXTRACTION METHODS, ESSENTIALS OF BOTANICAL EXTRACTION, PP. 83-136, (2015); LIU Y., YU J., WANG X., EXTRACTION OF POLICOSANOLS FROM HYDROLYSED RICE BRAN WAX BY HIGH-INTENSITY ULTRASOUND, INT. J. FOOD SCI. TECHNOL., 43, PP. 763-769, (2008); CHOTIMARKORN C., BENJAKUL S., SILALAI N., ANTIOXIDANT COMPONENTS AND PROPERTIES OF FIVE LONG-GRAINED RICE BRAN EXTRACTS FROM COMMERCIAL AVAILABLE CULTIVARS IN THAILAND, FOOD CHEM., 111, PP. 636-641, (2008); LILITCHAN S., ET AL., PARTIAL EXTRACTION METHOD FOR THE RAPID ANALYSIS OF TOTAL LIPIDS AND Γ-ORYZANOL CONTENTS IN RICE BRAN, FOOD CHEM., 106, PP. 752-759, (2008); LAI P., LI K.Y., LU S., CHEN H.H., PHYTOCHEMICALS AND ANTIOXIDANT PROPERTIES OF SOLVENT EXTRACTS FROM JAPONICA RICE BRAN, FOOD CHEM., 117, PP. 538-544, (2009); BHATNAGAR A.S., PRABHAKAR D.S., PRASANTH KUMAR P.K., RAJA RAJAN R.G., GOPALA KRISHNA A.G., PROCESSING OF COMMERCIAL RICE BRAN FOR THE PRODUCTION OF FAT AND NUTRACEUTICAL RICH RICE BROKENS, RICE GERM AND PURE BRAN, LWT FOOD SCI. TECHNOL., 58, PP. 306-311, (2014); CHEN F., ET AL., PURIFICATION PROCESS OF OCTACOSANOL EXTRACTS FROM RICE BRAN WAX BY MOLECULAR DISTILLATION, J. FOOD ENG., 79, PP. 63-68, (2007); LORENZ P., ET AL., NATURAL WAX CONSTITUENTS OF A SUPERCRITICAL FLUID CO<SUB>2</SUB> EXTRACT FROM QUINCE (CYDONIA OBLONGA MILL) POMACE, ANAL. BIOANAL. CHEM., 391, PP. 633-646, (2008); INTERNATIONAL COUNCIL FOR HARMONISATION OF TECHNICAL REQUIREMENTS FOR PHARMACEUTICALS FOR HUMAN USE (ICH), ICH Q3C MAINTENANCE PROCEDURES FOR THE GUIDANCE FOR INDUSTRY Q3C IMPURITIES: RESIDUAL SOLVENTS, (2017); PATNAIK P., A COMPREHENSIVE GUIDE TO THE HAZARDOUS PROPERTIES OF CHEMICAL SUBSTANCES, (2006); EVALUATION REPORT OF FOOD ADDITIVES ACETALDEHYDE. FOOD SAFETY COMMISSION OF JAPAN, (2005)","M. WEERAWATANAKORN; DEPARTMENT OF AGRO-INDUSTRY, FACULTY OF AGRICULTURE, NATURAL RESOURCES AND ENVIRONMENT, NARESUAN UNIVERSITY, PHITSANULOK, 99 MOO 9, THA PHO, MUEANG, 65000, THAILAND; EMAIL: MONTHANAC@NU.AC.TH","NATURE RESEARCH","ENGLISH","SCI. REP.","ARTICLE","ISI","2-S2.0-85097045016","SCI REP","NARESUAN UNIVERSITY;NARESUAN UNIVERSITY;NARESUAN UNIVERSITY","NOTREPORTED;NARESUAN UNIVERSITY;NOTREPORTED",NA,"WONGWAIWECH D, 2020, SCI REP","WONGWAIWECH D, 2020, SCI REP"
"LI J;SUN D;QIAN L;LIU Y","LI JINWEI;SUN DEWEI;QIAN LIGE;LIU YUANFA","SUBCRITICAL BUTANE EXTRACTION OF WHEAT GERM OIL AND ITS DEACIDIFICATION BY MOLECULAR DISTILLATION",2016,"MOLECULES","21",NA,16,"10.3390/molecules21121675","LIU, YF (CORRESPONDING AUTHOR), JIANGNAN UNIV, STATE KEY LAB FOOD SCI \& TECHNOL, COLLABORAT INNOVAT CTR FOOD SAFETY \& QUAL CONTROL, WUXI 214122, PEOPLES R CHINA.; LI, JINWEI; SUN, DEWEI; QIAN, LIGE; LIU, YUANFA, JIANGNAN UNIV, STATE KEY LAB FOOD SCI \& TECHNOL, COLLABORAT INNOVAT CTR FOOD SAFETY \& QUAL CONTROL, WUXI 214122, PEOPLES R CHINA.","EXTRACTION AND DEACIDIFICATION ARE IMPORTANT STAGES FOR WHEAT GERM OIL (WGO) PRODUCTION. CRUDE WGO WAS EXTRACTED USING SUBCRITICAL BUTANE EXTRACTION (SBE) AND COMPARED WITH TRADITIONAL SOLVENT EXTRACTION (SE) AND SUPERCRITICAL CARBON DIOXIDE EXTRACTION (SCE) BASED ON THE YIELD, CHEMICAL INDEX AND FATTY ACID PROFILE. FURTHERMORE, THE EFFECTS OF THE MOLECULAR DISTILLATION TEMPERATURE ON THE QUALITY OF WGO WERE ALSO INVESTIGATED IN THIS STUDY. RESULTS INDICATED THAT WGO EXTRACTED BY SBE HAS A HIGHER YIELD OF 9.10\% AND BETTER QUALITY; AT THE SAME TIME, ITS FATTY ACID COMPOSITION HAS NO SIGNIFICANT DIFFERENCE COMPARED WITH THAT OF SE AND SCE. THE MOLECULAR DISTILLATION EXPERIMENT SHOWED THAT THE ACID VALUE, PEROXIDE VALUE AND P-ANISIDINE VALUE OF WGO WERE REDUCED WITH THE INCREASE OF THE EVAPORATION TEMPERATURES, AND THE CONTENTS OF THE ACTIVE CONSTITUENTS OF TOCOPHEROL, POLYPHENOLS AND PHYTOSTEROLS ARE SIMULTANEOUSLY DECREASED. GENERALLY, THE DISTILLATION TEMPERATURE OF 150 DEGREES C IS AN APPROPRIATE CONDITION FOR WGO DEACIDIFICATION WITH THE HIGHER DEACIDIFICATION EFFICIENCY OF 77.78\% AND THE HIGHER RETENTION RATE OF ACTIVE CONSTITUENTS.","WHEAT GERM OIL; SUBCRITICAL BUTANE EXTRACTION; MOLECULAR DISTILLATION","SUPERCRITICAL-FLUID EXTRACTION; SEED OIL; POLICOSANOL CONTENTS; CARBON-DIOXIDE; PROPANE; CO2; TOCOPHEROLS; CULTIVARS; KINETICS","NATIONAL NATURAL SCIENCE FOUNDATION OF CHINA [31571878]; PUBLIC SECTOR RESEARCH SPECIAL FOOD [201313011-7-3]; BEIJING MUNICIPAL SCIENCE AND TECHNOLOGY PROJECT [D151100004015003]","THIS WORK WAS SUPPORTED BY THE NATIONAL NATURAL SCIENCE FOUNDATION OF CHINA (31571878), THE PUBLIC SECTOR RESEARCH SPECIAL FOOD (201313011-7-3), AND THE BEIJING MUNICIPAL SCIENCE AND TECHNOLOGY PROJECT (D151100004015003).","AHANGARI B, 2012, THEOR FOUND CHEM EN+, V46, P258, DOI 10.1134/S0040579512030013; ARZATE-MARTÍNEZ G, 2011, IND ENG CHEM RES, V50, P11237, DOI 10.1021/IE200096Q; BATISTELLA CB, 1998, COMPUT CHEM ENG, V22, PS53, DOI 10.1016/S0098-1354(98)00038-6; CHEN F, 2007, J FOOD ENG, V79, P63, DOI 10.1016/J.JFOODENG.2006.01.030; DE MORAES EB, 2006, APPL BIOCHEM BIOTECH, V132, P1066; DUNFORD NT, 2003, FOOD RES INT, V36, P905, DOI 10.1016/S0963-9969(03)00099-1; EISENMENGER M, 2006, J AM OIL CHEM SOC, V83, P863, DOI 10.1007/S11746-006-5038-6; FIORI L, 2014, J SUPERCRIT FLUID, V94, P71, DOI 10.1016/J.SUPFLU.2014.06.021; SOLAESA AG, 2016, FOOD CHEM, V190, P960, DOI 10.1016/J.FOODCHEM.2015.06.061; GHAZANI SM, 2013, J AM OIL CHEM SOC, V90, P743, DOI 10.1007/S11746-013-2215-2; HERRERO M, 2006, FOOD CHEM, V98, P136, DOI 10.1016/J.FOODCHEM.2005.05.058; ILLÉS V, 2000, J SUPERCRIT FLUID, V17, P177, DOI 10.1016/S0896-8446(99)00049-2; IRMAK S, 2006, FOOD CHEM, V95, P312, DOI 10.1016/J.FOODCHEM.2005.01.009; IRMAK S, 2005, J AGR FOOD CHEM, V53, P5583, DOI 10.1021/JF050508R; KRINGS U, 2000, FOOD CHEM, V71, P91, DOI 10.1016/S0308-8146(00)00148-5; LI JW, 2016, FOOD ANAL METHOD, V9, P1444, DOI 10.1007/S12161-015-0324-2; LI JW, 2005, PROCESS BIOCHEM, V40, P3607, DOI 10.1016/J.PROCBIO.2005.03.005; LIANG SH, 2010, J AM OIL CHEM SOC, V87, P63, DOI 10.1007/S11746-009-1475-3; MARIOD AA, 2011, J AM OIL CHEM SOC, V88, P931, DOI 10.1007/S11746-010-1754-Z; MARTINELLO M, 2007, J FOOD ENG, V81, P60, DOI 10.1016/J.JFOODENG.2006.10.012; MARTINELLO MA, 2007, J SCI FOOD AGR, V87, P1559, DOI 10.1002/JSFA.2888; MICHAEL E., 2008, J AM OIL CHEM SOC, V85, P55; MITEI YC, 2009, J AM OIL CHEM SOC, V86, P617, DOI 10.1007/S11746-009-1384-5; PAQUOT C., 1987, INT UNION PURE APPL, P212; PASSOS CP, 2010, CHEM ENG J, V160, P634, DOI 10.1016/J.CEJ.2010.03.087; PIRAS A, 2009, MOLECULES, V14, P2573, DOI 10.3390/MOLECULES14072573; SANTOS KA, 2015, J SUPERCRIT FLUID, V104, P54, DOI 10.1016/J.SUPFLU.2015.05.026; TRES MV, 2014, FOOD RES INT, V63, P33, DOI 10.1016/J.FOODRES.2014.02.004; WANG T, 2001, J AM OIL CHEM SOC, V78, P71, DOI 10.1007/S11746-001-0222-2; WU WL, 2012, LWT-FOOD SCI TECHNOL, V46, P563, DOI 10.1016/J.LWT.2011.10.028; YANG M, 2011, J AM OIL CHEM SOC, V88, P1633, DOI 10.1007/S11746-011-1822-Z; YEOH CM, 2014, EUR J LIPID SCI TECH, V116, P1654, DOI 10.1002/EJLT.201300502; ZANQUI AB, 2015, FOOD CHEM, V188, P452, DOI 10.1016/J.FOODCHEM.2015.05.033; ZHANG GY, 2013, IND ENG CHEM RES, V52, P3918, DOI 10.1021/IE3020044","LIU, YF (CORRESPONDING AUTHOR), JIANGNAN UNIV, STATE KEY LAB FOOD SCI \& TECHNOL, COLLABORAT INNOVAT CTR FOOD SAFETY \& QUAL CONTROL, WUXI 214122, PEOPLES R CHINA","MDPI AG","ENGLISH","MOLECULES","ARTICLE","ISI","WOS000392140100069","MOLECULES","JIANGNAN UNIV;JIANGNAN UNIV","JIANGNAN UNIV",NA,"LI J, 2016, MOLECULES","LI J, 2016, MOLECULES"
"TEIXEIRA F;VIDIGAL S;PIMENTEL L;L. L;COSTA P;TAVARES-VALENTE D;AZEVEDO-SILVA ;JOAO J;PINTADO M;FERNANDES J;RODRIGUEZ-ALCALA L","TEIXEIRA FRANCISCA S;VIDIGAL SUSANA S M P;PIMENTEL LIGIA; L;COSTA PAULA T;TAVARES-VALENTE DIANA;AZEVEDO-SILVA; JOAO;PINTADO MANUELA E;FERNANDES JOAO C; RODRIGUEZ-ALCALA LUIS M","PHYTOSTEROLS AND NOVEL TRITERPENES RECOVERED FROM INDUSTRIAL FERMENTATION COPRODUCTS EXERT IN VITRO ANTIINFLAMMATORY ACTIVITY IN MACROPHAGES",2021,"PHARMACEUTICALS","14",NA,9,"10.3390/ph14060583","RODRÍGUEZ-ALCALÁ, LM (CORRESPONDING AUTHOR), UNIV CATOLICA PORTUGUESA, ESCOLA SUPER BIOTECNOL, CBQF CTR BIOTECNOL \& QUIM FINA, LAB ASSOCIADO, RUA DIOGO BOTELHO 1327, P-4169005 PORTO, PORTUGAL.; TEIXEIRA, FRANCISCA S.; VIDIGAL, SUSANA S. M. P.; PIMENTEL, LIGIA L.; COSTA, PAULA T.; TAVARES-VALENTE, DIANA; AZEVEDO-SILVA, JOAO; PINTADO, MANUELA E.; FERNANDES, JOAO C.; RODRIGUEZ-ALCALA, LUIS M., UNIV CATOLICA PORTUGUESA, ESCOLA SUPER BIOTECNOL, CBQF CTR BIOTECNOL \& QUIM FINA, LAB ASSOCIADO, RUA DIOGO BOTELHO 1327, P-4169005 PORTO, PORTUGAL.","THE UNSTOPPABLE GROWTH OF HUMAN POPULATION THAT OCCURS IN PARALLEL WITH ALL MANUFACTURING ACTIVITIES LEADS TO A RELENTLESS INCREASE IN THE DEMAND FOR RESOURCES, CULTIVATION LAND, AND ENERGY. IN RESPONSE, CURRENTLY, THERE IS SIGNIFICANT INTEREST IN DEVELOPING STRATEGIES TO OPTIMIZE ANY AVAILABLE RESOURCES AND THEIR BIOWASTE. WHILE SOLUTIONS INITIALLY FOCUSED ON RECOVERING BIOMOLECULES WITH APPLICATIONS IN FOOD, ENERGY, OR MATERIALS, THE FEASIBILITY OF SYNTHETIC BIOLOGY IN THIS FIELD HAS BEEN DEMONSTRATED IN RECENT YEARS. FOR INSTANCE, IT IS POSSIBLE TO GENETICALLY MODIFY SACCHAROMYCES CEREVISIAE TO PRODUCE TERPENES FOR COMMERCIAL APPLICATIONS (I.E., AGAINST MALARIA OR AS BIODIESEL). BUT THE PRODUCTION PROCESS, SIMILAR TO ANY INDUSTRIAL ACTIVITY, GENERATES BIOWASTES CONTAINING PROMISING BIOMOLECULES (FROM FERMENTATION) THAT IF RECOVERED MAY HAVE APPLICATIONS IN DIFFERENT AREAS. TO TEST THIS HYPOTHESIS, IN THE PRESENT STUDY, THE LIPID COMPOSITION OF BY-PRODUCTS FROM THE INDUSTRIAL PRODUCTION OF BETA-FARNESENE BY GENETICALLY MODIFIED SACCHAROMYCES CEREVISIAE ARE STUDIED TO IDENTIFY POTENTIALLY BIOACTIVE COMPOUNDS, THEIR RECOVERY, AND FINALLY, THEIR STABILITY AND IN VITRO BIOACTIVITY. THE ASSAYED BIOWASTE SHOWED THE PRESENCE OF TRITERPENES, PHYTOSTEROLS, AND 1-OCTACOSANOL WHICH WERE RECOVERED THROUGH MOLECULAR DISTILLATION INTO A SINGLE FRACTION. DURING THE ASSAYED STABILITY TEST, COMPOSITIONAL MODIFICATIONS WERE OBSERVED, MAINLY FOR THE PHYTOSTEROLS AND 1-OCTACOSANOL, PROBABLY DUE TO OXIDATIVE REACTIONS. HOWEVER, SUCH CHANGES DID NOT AFFECT THE IN VITRO BIOACTIVITY IN MACROPHAGES, WHERE IT WAS FOUND THAT THE OBTAINED FRACTION DECREASED THE PRODUCTION OF TNF-ALPHA AND IL-6 IN LIPOPOLYSACCHARIDE (LPS)-INDUCED INFLAMMATION.","BIOWASTE; TRITERPENES; 1-OCTACOSANOL; PHYTOSTEROLS; STABILITY TEST; MOLECULAR DISTILLATION; MACROPHAGES; INFLAMMATION; IL-6","PERFORMANCE LIQUID-CHROMATOGRAPHY; BIOETHANOL PRODUCTION; ANTIOXIDANT; ACTIVITY; OXIDATION; WASTE; OCTACOSANOL; MODEL; POLICOSANOL; SEPARATION; STABILITY","ESCOLA SUPERIOR DE BIOTECNOLOGIA-UNIVERSIDADE CATOLICA PORTUGUESA THROUGH THE ALCHEMY PROJECT, CAPTURING HIGH VALUE FROM INDUSTRIAL FERMENTATION BIOPRODUCTS [POCI-01 0247-FEDER-027578]; FCT [UID/MULTI/50016/2019]; AMYRIS BIO PRODUCTS PORTUGAL UNIPESSOAL LDA","THIS WORK WAS SUPPORTED BY AMYRIS BIO PRODUCTS PORTUGAL UNIPESSOAL LDA AND ESCOLA SUPERIOR DE BIOTECNOLOGIA-UNIVERSIDADE CATOLICA PORTUGUESA THROUGH THE ALCHEMY PROJECT, CAPTURING HIGH VALUE FROM INDUSTRIAL FERMENTATION BIOPRODUCTS (POCI-01 0247-FEDER-027578). AUTHORS WOULD ALSO LIKE TO THANK THE SCIENTIFIC COLLABORATION UNDER THE FCT PROJECT UID/MULTI/50016/2019.","ABREU S, 2017, J CHROMATOGR A, V1514, P54, DOI 10.1016/J.CHROMA.2017.07.063; ALDINI R, 2014, PLOS ONE, V9, DOI 10.1371/JOURNAL.PONE.0108112; ANONYMOUS, 2019, WORLD POPULATION PRO, DOI DOI 10.18356/13BF5476-EN; ANONYMOUS, 2015, OECD FAO AGR OUTLOOK; ANONYMOUS, 2012, OFFICIAL JOURNAL OF THE EUROPEAN UNION L, V136, P1, DOI DOI 10.1016/B978-0-08-100922-2.00001-2; ASIKIN Y, 2012, EUR J LIPID SCI TECH, V114, P583, DOI 10.1002/EJLT.201100300; ATTARD TM, 2015, IND CROP PROD, V76, P95, DOI 10.1016/J.INDCROP.2015.05.077; BELL J, 2018, NEW BIOTECHNOL, V40, P25, DOI 10.1016/J.NBT.2017.06.010; BENTELDJOUNE M, 2021, NAT PROD RES, V35, P1639, DOI 10.1080/14786419.2019.1619722; BOBO-GARCÍA G, 2015, J SCI FOOD AGR, V95, P204, DOI 10.1002/JSFA.6706; BUSIC A, 2018, FOOD TECHNOL BIOTECH, V56, P289, DOI 10.17113/FTB.56.03.18.5546; CANIZARES D, 2019, IND CROP PROD, V141, DOI 10.1016/J.INDCROP.2019.111700; CHOE E, 2006, COMPR REV FOOD SCI F, V5, P169, DOI 10.1111/J.1541-4337.2006.00009.X; CORBERÁN VC, 2014, CATAL TODAY, V238, P49, DOI 10.1016/J.CATTOD.2014.03.033; CPMP/ICH, 2003, INT C HARM, V4, P1; D'AMATO D, 2017, J CLEAN PROD, V168, P716, DOI 10.1016/J.JCLEPRO.2017.09.053; DÁVALOS A, 2004, J AGR FOOD CHEM, V52, P48, DOI 10.1021/JF0305231; DE ALMEIDA DT, 2019, FOOD SCI TECH-BRAZIL, V39, P211, DOI 10.1590/FST.43317; DE OLIVEIRA S, 2014, QUIM NOVA, V37, P497, DOI 10.5935/0100-4042.20140076; GARCÍA-MARTÍNEZ MD, 2010, INT J FOOD SCI TECH, V45, P2337, DOI 10.1111/J.1365-2621.2010.02405.X; DEL RÍO JC, 2015, IND CROP PROD, V77, P992, DOI 10.1016/J.INDCROP.2015.09.064; DORMONT F, 2020, SCI ADV, V6, DOI 10.1126/SCIADV.AAZ5466; EJSING CS, 2009, P NATL ACAD SCI USA, V106, P2136, DOI 10.1073/PNAS.0811700106; EKINCI N, 2016, TURK J AGRIC FOR, V40, P38, DOI 10.3906/TAR-1411-91; FADHIL AB, 2017, FUEL, V210, P721, DOI 10.1016/J.FUEL.2017.09.009; FAOSTAT, FAOSTAT STAT DAT; FENG J, 2019, SCI ADV, V5, DOI 10.1126/SCIADV.AAU5148; FENG SM, 2015, FOOD CHEM, V182, P171, DOI 10.1016/J.FOODCHEM.2015.03.003; FISHER K., 2009, U.S. PATENT, PATENT NO. 7,592,295, 7592295; FOUQUET TNJ, 2019, J MASS SPECTROM, V54, P933, DOI 10.1002/JMS.4480; GACHUMI G, 2021, PHARMACEUTICS, V13, DOI 10.3390/PHARMACEUTICS13020268; GEISSDOERFER M, 2017, J CLEAN PROD, V143, P757, DOI 10.1016/J.JCLEPRO.2016.12.048; GEORGE S., 2001, INFRARED AND RAMAN CHARACTERISTIC GROUP FREQUENCIES: TABLES AND CHARTS, VTHIRD; GREENSPAN L, 1977, J RES NBS A PHYS CH, V81, P89, DOI 10.6028/JRES.081A.011; GUO TY, 2017, J AGR FOOD CHEM, V65, P3647, DOI 10.1021/ACS.JAFC.6B05465; HANSON R., GREAT FILTER; HOMAN R, 1998, J CHROMATOGR B, V708, P21, DOI 10.1016/S0378-4347(97)00651-8; ISHAKA A, 2014, INT J NANOMED, V9, P2261, DOI 10.2147/IJN.S56999; ISHIDA T, 2012, CHEMSUSCHEM, V5, P2243, DOI 10.1002/CSSC.201200324; JAMBO SA, 2016, RENEW SUST ENERG REV, V65, P756, DOI 10.1016/J.RSER.2016.07.064; KAUSHIK MK, 2017, SCI REP-UK, V7, DOI 10.1038/S41598-017-08874-2; KHOR YP, 2019, FOODS, V8, DOI 10.3390/FOODS8100475; KIM SM, 2014, J CEREAL SCI, V60, P243, DOI 10.1016/J.JCS.2014.04.001; KLUNKLIN W, 2021, POLYMERS-BASEL, V13, DOI 10.3390/POLYM13010081; LEE JK, 2020, BIORESOURCE TECHNOL, V298, DOI 10.1016/J.BIORTECH.2019.122346; LEE SH, 2019, INT J SPORT PHYSIOL, V14, P1297, DOI 10.1123/IJSPP.2018-0704; LENGYEL J, 2012, FOOD CHEM, V133, P1435, DOI 10.1016/J.FOODCHEM.2012.02.031; LIU CY, 2020, BIOMED PHARMACOTHER, V128, DOI 10.1016/J.BIOPHA.2020.110252; MEADOWS AL, 2016, NATURE, V537, P694, DOI 10.1038/NATURE19769; MELLO BLB, 2021, TROP ANIM HEALTH PRO, V53, DOI 10.1007/S11250-021-02640-3; NALLATHAMBY N, 2015, NAT PROD COMMUN, V10, P885; NAUTIYAL P, 2017, CLEAN TECHNOL ENVIR, V19, P1667, DOI 10.1007/S10098-017-1355-8; PADDON CJ, 2013, NATURE, V496, P528, DOI 10.1038/NATURE12051; PICCIRILLO C, 2014, J MATER CHEM B, V2, P5999, DOI 10.1039/C4TB00984C; PIMENTEL D., 2017, ENCY ANTHROPOCENE, V1, P313; PIMENTEL LL, 2021, BBA-MOL CELL BIOL L, V1866, DOI 10.1016/J.BBALIP.2020.158839; RAHMANIA H, 2020, SCI REP-UK, V10, DOI 10.1038/S41598-020-71020-Y; REDDY LH, 2009, ADV DRUG DELIVER REV, V61, P1412, DOI 10.1016/J.ADDR.2009.09.005; RODRÍGUEZ-ALCALÁ LM, 2007, J AGR FOOD CHEM, V55, P6533, DOI 10.1021/JF0708591; ROUKAS T, 2020, J CLEAN PROD, V257, DOI 10.1016/J.JCLEPRO.2020.120519; SAHU P, 2019, IND ENG CHEM RES, V58, P20946, DOI 10.1021/ACS.IECR.9B02001; SÁNCHEZ-MORENO C, 2002, FOOD SCI TECHNOL INT, V8, P121, DOI 10.1177/1082013202008003770, 10.1106/108201302026770; SHARMA R, 2019, SCI REP-UK, V9, DOI 10.1038/S41598-019-41631-1; SUGAWARA T, 1999, LIPIDS, V34, P1231, DOI 10.1007/S11745-999-0476-3; TEGENGE MA, 2019, REGUL TOXICOL PHARM, V108, DOI 10.1016/J.YRTPH.2019.104436; TOCI AT, 2013, LWT-FOOD SCI TECHNOL, V50, P581, DOI 10.1016/J.LWT.2012.08.007; WILLETT W, 2019, LANCET, V393, P447, DOI 10.1016/S0140-6736(18)31788-4; XU P, 2012, ACS SYNTH BIOL, V1, P256, DOI 10.1021/SB300016B; YOO T, 2017, RUBBER CHEM TECHNOL, V90, P308, DOI 10.5254/RCT.17.82683; YU L., 2007, WHEAT ANTIOXIDANTS; YUAN LL, 2019, FOODS, V8, DOI 10.3390/FOODS8110582; ZABED H, 2017, RENEW SUST ENERG REV, V71, P475, DOI 10.1016/J.RSER.2016.12.076; ZHANG JZ, 2021, CURR OPIN BIOTECH, V67, P88, DOI 10.1016/J.COPBIO.2021.01.010; ZHANG YP, 2017, FEMS YEAST RES, V17, DOI 10.1093/FEMSYR/FOX080","RODRÍGUEZ-ALCALÁ, LM (CORRESPONDING AUTHOR), UNIV CATOLICA PORTUGUESA, ESCOLA SUPER BIOTECNOL, CBQF CTR BIOTECNOL \& QUIM FINA, LAB ASSOCIADO, RUA DIOGO BOTELHO 1327, P-4169005 PORTO, PORTUGAL","MDPI","ENGLISH","PHARMACEUTICALS","ARTICLE","ISI","WOS000665880900001","PHARMACEUTICALS","UNIV CATOLICA PORTUGUESA;TAVARES-VALENTE;UNIV CATOLICA PORTUGUESA","UNIV CATOLICA PORTUGUESA",NA,"TEIXEIRA FS, 2021, PHARMACEUTICALS","TEIXEIRA FS, 2021, PHARMACEUTICALS"