Published July 1, 2024 | Version v2
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Optimization of metabolic states

  • 1. Systems Biotechnology, School of Engineering and Design, Technical University of Munich, Germany
  • 2. Universit√© Paris-Saclay, INRAE, MaIAGE, 78350 Jouy-en-Josas, France
  • 3. Department of Plant and Environmental Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel
  • 4. Swammerdam Institute for Life Sciences, University of Amsterdam, the Netherlands


This is a chapter from the free textbook "Economic Principles in Cell Biology"

Enzyme-efficient states are metabolic states that realize a given flux objective at a minimal enzyme cost. In models without further constraints, enzyme-efficient states are Elementary Flux Modes (EFMs). Elementary Flux Modes can be used to find enzyme-efficient states in networks that would be too large to optimize metabolic states "by brute force". Biomass per enzyme efficiency can be converted to into cell growth rate. As growth conditions are changing, the flux profile either changes proportionally (and metabolite and enzyme concentrations change continuously) or fluxes change discontinuously together with metabolite and enzyme concentrations.



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