Features of clinical course of chronic hepatitis in children with oenological diseases

Nezgoda I. I., Moroz L. V., Singh S., Singh O. O. Features of clinical course of chronic hepatitis in children with oenological diseases. Journal of Education, Health and Sport. 2017;7(4):880-896. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1209363

http://ojs.ukw.edu.pl/index.php/johs/article/view/5392

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© The Author (s) 2017;

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This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial

use, distribution and reproduction in any medium, provided the work is properly cited.

The authors declare that there is no conflict of interests regarding the publication of this paper.

Received: 12.04.2017. Revised 10.04.2017. Accepted: 25.04.2017.

FEATURES OF CLINICAL COURSE OF CHRONIC HEPATITIS IN CHILDREN WITH ONCOLOGICAL DISEASES

I. I. Nezgoda, L. V. Moroz, S. Singh, O. O. Singh

National Pirogov Memorial Medical University, Vinnytsia, Ukraine

Abstract

The article presents the results of the study including 187 children with chronic hepatitis aged from 3 to 18 years. All were under dispensary observation at the Regional Pediatric Infectious Diseases Hospital, Vinnytsia, Ukraine, till April 30, 2017. The features of clinical symptoms in 82 children with chronic hepatitis B and C with oncological diseases were also defined.

It was determined that among the dispensary observation group of children, 70 (37,4%) patients were with chronic hepatitis B (HBV), 99 (53%) – chronic hepatitis C (CHC), mіх - hepatitis (B + C) were diagnosed in 9,6% (18) patients. In 82 children (43,8%), chronic hepatitis was acquired on the background of the existing oncological disease. In general, hepatitis developed in children with acute lymphoblastic leukemia 61% (50 patients). Most of the children were with age 9-18 (53,4%). Among the patients of CHB 32 (45,7%) were with oncohematological diseases. While in children with CHC such patients were 35 (35,3%), in the group of mіх - hepatitis (B + C) – 83,3% (15 patients) were with oncohematological diseases.

Hepatitis in patients with cancer develops in a primary - chronic form (91,5%) with minimal clinical signs of the disease, 8,5% of patients develop manifest disease pattern, 6,09% of patients the phenomenon of self - elimination of the virus were observed. Chronic hepatitis was with normal bilirubin count and fractions. In 1/3 of the patients, the liver enzymes were normal, despite of this all patients had a high viral load. Deep fibrosis changes in liver were found in the children of older age group and the degree of fibrosis increases with the increase in age.

Key words: chronic hepatitis B, chronic hepatitis C, children, oncological diseases.